Cayman
Showing 43651–43800 of 45550 results
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Vatalanib is an antagonist of the VEGF receptors, inhibiting the receptor tyrosine kinase activities of VEGFR1 (Flt1), VEGFR2 (KDR), and VEGFR3 (Flt4) with IC50 values of 77, 37, and 190 nM, respectively.{24346,24345} It less potently inhibits PDGF and c-Kit (IC50 = 600 and 700 nM) and has no effect on a large panel of additional kinases.{24346,24344,24345} Vatalanib completely blocks retinal neovascularization in oxygen-induced ischemic retinopathy in mice, suggesting its use in diabetic retinopathy and other diseases featuring aberrant vascular development.{18281,24343}
Brand:CaymanSKU:- Vatalanib is an antagonist of the VEGF receptors, inhibiting the receptor tyrosine kinase activities of VEGFR1 (Flt1), VEGFR2 (KDR), and VEGFR3 (Flt4) with IC50 values of 77, 37, and 190 nM, respectively.{24346,24345} It less potently inhibits PDGF and c-Kit (IC50 = 600 and 700 nM) and has no effect on a large panel of additional kinases.{24346,24344,24345} Vatalanib completely blocks retinal neovascularization in oxygen-induced ischemic retinopathy in mice, suggesting its use in diabetic retinopathy and other diseases featuring aberrant vascular development.{18281,24343}
Brand:CaymanSKU:- Vatalanib is an antagonist of the VEGF receptors, inhibiting the receptor tyrosine kinase activities of VEGFR1 (Flt1), VEGFR2 (KDR), and VEGFR3 (Flt4) with IC50 values of 77, 37, and 190 nM, respectively.{24346,24345} It less potently inhibits PDGF and c-Kit (IC50 = 600 and 700 nM) and has no effect on a large panel of additional kinases.{24346,24344,24345} Vatalanib completely blocks retinal neovascularization in oxygen-induced ischemic retinopathy in mice, suggesting its use in diabetic retinopathy and other diseases featuring aberrant vascular development.{18281,24343}
Brand:CaymanSKU:- Vatalanib is an antagonist of the VEGF receptors, inhibiting the receptor tyrosine kinase activities of VEGFR1 (Flt1), VEGFR2 (KDR), and VEGFR3 (Flt4) with IC50 values of 77, 37, and 190 nM, respectively.{24346,24345} It less potently inhibits PDGF and c-Kit (IC50 = 600 and 700 nM) and has no effect on a large panel of additional kinases.{24346,24344,24345} Vatalanib completely blocks retinal neovascularization in oxygen-induced ischemic retinopathy in mice, suggesting its use in diabetic retinopathy and other diseases featuring aberrant vascular development.{18281,24343}
Brand:CaymanSKU:-
Vatiquinone is a metabolite of α-tocotrienol (Item No. 10008377) that has antioxidant and ferroptosis inhibitory activity.{56151,56152} It inhibits decreases in cell viability induced by the γ-glutamylcysteine synthetase inhibitor L-buthionine-(S,R)-sulfoximine (BSO; Item No. 14484) in primary fibroblasts isolated from patients with the mitochondrial diseases Friedreich’s ataxia or Leigh syndrome (EC50s = 24 and 30 nM, respectively).{56151} Vatiquinone inhibits cell death and lipid peroxidation induced by the glutathione peroxidase 4 (GPX4) inhibitor RSL3 in primary fibroblasts isolated from patients with the mitochondrial encephalopathic epilepsy disease pontocerebellar hypoplasia type 6 (PCH6; EC50s = 17.3-21.8 and 33.1-57.6 nM, respectively).{56152}
Brand:CaymanSKU:26819 - 1 mgAvailable on backorder
Vatiquinone is a metabolite of α-tocotrienol (Item No. 10008377) that has antioxidant and ferroptosis inhibitory activity.{56151,56152} It inhibits decreases in cell viability induced by the γ-glutamylcysteine synthetase inhibitor L-buthionine-(S,R)-sulfoximine (BSO; Item No. 14484) in primary fibroblasts isolated from patients with the mitochondrial diseases Friedreich’s ataxia or Leigh syndrome (EC50s = 24 and 30 nM, respectively).{56151} Vatiquinone inhibits cell death and lipid peroxidation induced by the glutathione peroxidase 4 (GPX4) inhibitor RSL3 in primary fibroblasts isolated from patients with the mitochondrial encephalopathic epilepsy disease pontocerebellar hypoplasia type 6 (PCH6; EC50s = 17.3-21.8 and 33.1-57.6 nM, respectively).{56152}
Brand:CaymanSKU:26819 - 10 mgAvailable on backorder
Vatiquinone is a metabolite of α-tocotrienol (Item No. 10008377) that has antioxidant and ferroptosis inhibitory activity.{56151,56152} It inhibits decreases in cell viability induced by the γ-glutamylcysteine synthetase inhibitor L-buthionine-(S,R)-sulfoximine (BSO; Item No. 14484) in primary fibroblasts isolated from patients with the mitochondrial diseases Friedreich’s ataxia or Leigh syndrome (EC50s = 24 and 30 nM, respectively).{56151} Vatiquinone inhibits cell death and lipid peroxidation induced by the glutathione peroxidase 4 (GPX4) inhibitor RSL3 in primary fibroblasts isolated from patients with the mitochondrial encephalopathic epilepsy disease pontocerebellar hypoplasia type 6 (PCH6; EC50s = 17.3-21.8 and 33.1-57.6 nM, respectively).{56152}
Brand:CaymanSKU:26819 - 25 mgAvailable on backorder
Vatiquinone is a metabolite of α-tocotrienol (Item No. 10008377) that has antioxidant and ferroptosis inhibitory activity.{56151,56152} It inhibits decreases in cell viability induced by the γ-glutamylcysteine synthetase inhibitor L-buthionine-(S,R)-sulfoximine (BSO; Item No. 14484) in primary fibroblasts isolated from patients with the mitochondrial diseases Friedreich’s ataxia or Leigh syndrome (EC50s = 24 and 30 nM, respectively).{56151} Vatiquinone inhibits cell death and lipid peroxidation induced by the glutathione peroxidase 4 (GPX4) inhibitor RSL3 in primary fibroblasts isolated from patients with the mitochondrial encephalopathic epilepsy disease pontocerebellar hypoplasia type 6 (PCH6; EC50s = 17.3-21.8 and 33.1-57.6 nM, respectively).{56152}
Brand:CaymanSKU:26819 - 5 mgAvailable on backorder
VBIT-12 is a voltage-dependent anion channel 1 (VDAC1) inhibitor.{57236} It inhibits VDAC1 conductance in synthetic lipid membranes containing purified rat VDAC1 when used at concentrations ranging from 20 to 100 µM.
Brand:CaymanSKU:31445 - 1 mgAvailable on backorder
VBIT-12 is a voltage-dependent anion channel 1 (VDAC1) inhibitor.{57236} It inhibits VDAC1 conductance in synthetic lipid membranes containing purified rat VDAC1 when used at concentrations ranging from 20 to 100 µM.
Brand:CaymanSKU:31445 - 10 mgAvailable on backorder
VBIT-12 is a voltage-dependent anion channel 1 (VDAC1) inhibitor.{57236} It inhibits VDAC1 conductance in synthetic lipid membranes containing purified rat VDAC1 when used at concentrations ranging from 20 to 100 µM.
Brand:CaymanSKU:31445 - 25 mgAvailable on backorder
VBIT-12 is a voltage-dependent anion channel 1 (VDAC1) inhibitor.{57236} It inhibits VDAC1 conductance in synthetic lipid membranes containing purified rat VDAC1 when used at concentrations ranging from 20 to 100 µM.
Brand:CaymanSKU:31445 - 5 mgAvailable on backorder
VCP171 is a positive allosteric modulator of adenosine A1 receptors (EC50 = 15.8 μM in a kinetic assay measuring agonist dissociation).{61017}. It reduces AMPA receptor-mediated evoked excitatory postsynaptic currents (eEPSCs) in lamina I and lamina II neurons in a rat model of neuropathic pain (EC50s = 1.995 and 0.251 μM, respectively) to a greater extent than in sham control animals (EC50s = 2.512 and 0.631 μM, respectively).{45812}
Brand:CaymanSKU:30309 - 1 mgAvailable on backorder
VCP171 is a positive allosteric modulator of adenosine A1 receptors (EC50 = 15.8 μM in a kinetic assay measuring agonist dissociation).{61017}. It reduces AMPA receptor-mediated evoked excitatory postsynaptic currents (eEPSCs) in lamina I and lamina II neurons in a rat model of neuropathic pain (EC50s = 1.995 and 0.251 μM, respectively) to a greater extent than in sham control animals (EC50s = 2.512 and 0.631 μM, respectively).{45812}
Brand:CaymanSKU:30309 - 10 mgAvailable on backorder
VCP171 is a positive allosteric modulator of adenosine A1 receptors (EC50 = 15.8 μM in a kinetic assay measuring agonist dissociation).{61017}. It reduces AMPA receptor-mediated evoked excitatory postsynaptic currents (eEPSCs) in lamina I and lamina II neurons in a rat model of neuropathic pain (EC50s = 1.995 and 0.251 μM, respectively) to a greater extent than in sham control animals (EC50s = 2.512 and 0.631 μM, respectively).{45812}
Brand:CaymanSKU:30309 - 25 mgAvailable on backorder
VCP171 is a positive allosteric modulator of adenosine A1 receptors (EC50 = 15.8 μM in a kinetic assay measuring agonist dissociation).{61017}. It reduces AMPA receptor-mediated evoked excitatory postsynaptic currents (eEPSCs) in lamina I and lamina II neurons in a rat model of neuropathic pain (EC50s = 1.995 and 0.251 μM, respectively) to a greater extent than in sham control animals (EC50s = 2.512 and 0.631 μM, respectively).{45812}
Brand:CaymanSKU:30309 - 5 mgAvailable on backorder
Numerous analogs of arachidonoyl ethanolamide (AEA) potentiate its biological activity. This potentiation is ascribed either to inhibition of AEA reuptake into neurons, or inhibition of fatty amide acyl hydrolase (FAAH) within the neurons.{10254,10647} VDM11 is an AEA transport inhibitor with essentially no activity on either the central cannabinoid receptor (CB1), peripheral cannabinoid receptor (CB2), or the vanilloid receptor 1 (VR1).{9577} However, VDM11 inhibits FAAH and monoacylglycerol lipase (MAGL) and may act as an alternative FAAH substrate.{14077} At a concentration of 3 µM, VDM11, like AM404, inhibits glutamergic synaptic transmission between hippocampal neurons.{12853} The mechanism of this effect may be a direct action on sodium channels. Thus, the use of anandamide analogs as uptake inhibitors and interpretation of the results must be undertaken with care.
Brand:CaymanSKU:10006731 - 10 mgAvailable on backorder
Numerous analogs of arachidonoyl ethanolamide (AEA) potentiate its biological activity. This potentiation is ascribed either to inhibition of AEA reuptake into neurons, or inhibition of fatty amide acyl hydrolase (FAAH) within the neurons.{10254,10647} VDM11 is an AEA transport inhibitor with essentially no activity on either the central cannabinoid receptor (CB1), peripheral cannabinoid receptor (CB2), or the vanilloid receptor 1 (VR1).{9577} However, VDM11 inhibits FAAH and monoacylglycerol lipase (MAGL) and may act as an alternative FAAH substrate.{14077} At a concentration of 3 µM, VDM11, like AM404, inhibits glutamergic synaptic transmission between hippocampal neurons.{12853} The mechanism of this effect may be a direct action on sodium channels. Thus, the use of anandamide analogs as uptake inhibitors and interpretation of the results must be undertaken with care.
Brand:CaymanSKU:10006731 - 25 mgAvailable on backorder
Numerous analogs of arachidonoyl ethanolamide (AEA) potentiate its biological activity. This potentiation is ascribed either to inhibition of AEA reuptake into neurons, or inhibition of fatty amide acyl hydrolase (FAAH) within the neurons.{10254,10647} VDM11 is an AEA transport inhibitor with essentially no activity on either the central cannabinoid receptor (CB1), peripheral cannabinoid receptor (CB2), or the vanilloid receptor 1 (VR1).{9577} However, VDM11 inhibits FAAH and monoacylglycerol lipase (MAGL) and may act as an alternative FAAH substrate.{14077} At a concentration of 3 µM, VDM11, like AM404, inhibits glutamergic synaptic transmission between hippocampal neurons.{12853} The mechanism of this effect may be a direct action on sodium channels. Thus, the use of anandamide analogs as uptake inhibitors and interpretation of the results must be undertaken with care.
Brand:CaymanSKU:10006731 - 5 mgAvailable on backorder
Numerous analogs of arachidonoyl ethanolamide (AEA) potentiate its biological activity. This potentiation is ascribed either to inhibition of AEA reuptake into neurons, or inhibition of fatty amide acyl hydrolase (FAAH) within the neurons.{10254,10647} VDM11 is an AEA transport inhibitor with essentially no activity on either the central cannabinoid receptor (CB1), peripheral cannabinoid receptor (CB2), or the vanilloid receptor 1 (VR1).{9577} However, VDM11 inhibits FAAH and monoacylglycerol lipase (MAGL) and may act as an alternative FAAH substrate.{14077} At a concentration of 3 µM, VDM11, like AM404, inhibits glutamergic synaptic transmission between hippocampal neurons.{12853} The mechanism of this effect may be a direct action on sodium channels. Thus, the use of anandamide analogs as uptake inhibitors and interpretation of the results must be undertaken with care.
Brand:CaymanSKU:10006731 - 50 mgAvailable on backorder
Ataxia-telangiectasia and Rad3-related protein (ATR) is a serine/threonine kinase that activates DNA processes related to the DNA damage response. VE-821 is an ATP-competitive inhibitor of ATR (IC50 = 26 nM).{28657,28655} It augments DNA damage and cell death of cancer cells in response to radiation under normal and hypoxic conditions.{28655,28656,28658} VE-821 also sensitizes cancer cells to chemotherapy.{28656,28654,28573}
Brand:CaymanSKU:-Available on backorder
Ataxia-telangiectasia and Rad3-related protein (ATR) is a serine/threonine kinase that activates DNA processes related to the DNA damage response. VE-821 is an ATP-competitive inhibitor of ATR (IC50 = 26 nM).{28657,28655} It augments DNA damage and cell death of cancer cells in response to radiation under normal and hypoxic conditions.{28655,28656,28658} VE-821 also sensitizes cancer cells to chemotherapy.{28656,28654,28573}
Brand:CaymanSKU:-Available on backorder
Ataxia-telangiectasia and Rad3-related protein (ATR) is a serine/threonine kinase that activates DNA processes related to the DNA damage response. VE-821 is an ATP-competitive inhibitor of ATR (IC50 = 26 nM).{28657,28655} It augments DNA damage and cell death of cancer cells in response to radiation under normal and hypoxic conditions.{28655,28656,28658} VE-821 also sensitizes cancer cells to chemotherapy.{28656,28654,28573}
Brand:CaymanSKU:-Available on backorder
VE-822 is an inhibitor of ataxia-telangiectasia mutated (ATM) Rad3-related protein kinase (ATR), a regulator of DNA damage repair, with Ki and IC50 values of in vitro.{36517} It is selective for ATR over ATM (Ki = 34 nM; IC50 = 2,600 nM) as well as DNA-PK, mTOR, and PI3Kγ (Kis = >4,000, >1,000, and 220 nM, respectively). In cultured COLO 205 colorectal cancer cells, VE-822 (80 nM) reduces the IC50 of the topoisomerase 1 inhibitor SN-38 (Item No. 15632) by at least 8-fold.{36519} In a mouse xenograft model, it delays the growth of radiation-treated PSN-1 pancreatic cancer xenografts by 2-3-fold relative to radiation alone when administered at a dose of 60 mg/kg. VE-822 also enhances the tumoricidal effects of cisplatin (Item No. 13119) against primary human lung cancer xenografts and the effects of the topoisomerase inhibitor irinotecan (Item No. 14180) against COLO 205 colorectal tumors in mice.{36519,36518}
Brand:CaymanSKU:24198 - 10 mgAvailable on backorder
VE-822 is an inhibitor of ataxia-telangiectasia mutated (ATM) Rad3-related protein kinase (ATR), a regulator of DNA damage repair, with Ki and IC50 values of in vitro.{36517} It is selective for ATR over ATM (Ki = 34 nM; IC50 = 2,600 nM) as well as DNA-PK, mTOR, and PI3Kγ (Kis = >4,000, >1,000, and 220 nM, respectively). In cultured COLO 205 colorectal cancer cells, VE-822 (80 nM) reduces the IC50 of the topoisomerase 1 inhibitor SN-38 (Item No. 15632) by at least 8-fold.{36519} In a mouse xenograft model, it delays the growth of radiation-treated PSN-1 pancreatic cancer xenografts by 2-3-fold relative to radiation alone when administered at a dose of 60 mg/kg. VE-822 also enhances the tumoricidal effects of cisplatin (Item No. 13119) against primary human lung cancer xenografts and the effects of the topoisomerase inhibitor irinotecan (Item No. 14180) against COLO 205 colorectal tumors in mice.{36519,36518}
Brand:CaymanSKU:24198 - 25 mgAvailable on backorder
VE-822 is an inhibitor of ataxia-telangiectasia mutated (ATM) Rad3-related protein kinase (ATR), a regulator of DNA damage repair, with Ki and IC50 values of in vitro.{36517} It is selective for ATR over ATM (Ki = 34 nM; IC50 = 2,600 nM) as well as DNA-PK, mTOR, and PI3Kγ (Kis = >4,000, >1,000, and 220 nM, respectively). In cultured COLO 205 colorectal cancer cells, VE-822 (80 nM) reduces the IC50 of the topoisomerase 1 inhibitor SN-38 (Item No. 15632) by at least 8-fold.{36519} In a mouse xenograft model, it delays the growth of radiation-treated PSN-1 pancreatic cancer xenografts by 2-3-fold relative to radiation alone when administered at a dose of 60 mg/kg. VE-822 also enhances the tumoricidal effects of cisplatin (Item No. 13119) against primary human lung cancer xenografts and the effects of the topoisomerase inhibitor irinotecan (Item No. 14180) against COLO 205 colorectal tumors in mice.{36519,36518}
Brand:CaymanSKU:24198 - 5 mgAvailable on backorder
VE-822 is an inhibitor of ataxia-telangiectasia mutated (ATM) Rad3-related protein kinase (ATR), a regulator of DNA damage repair, with Ki and IC50 values of in vitro.{36517} It is selective for ATR over ATM (Ki = 34 nM; IC50 = 2,600 nM) as well as DNA-PK, mTOR, and PI3Kγ (Kis = >4,000, >1,000, and 220 nM, respectively). In cultured COLO 205 colorectal cancer cells, VE-822 (80 nM) reduces the IC50 of the topoisomerase 1 inhibitor SN-38 (Item No. 15632) by at least 8-fold.{36519} In a mouse xenograft model, it delays the growth of radiation-treated PSN-1 pancreatic cancer xenografts by 2-3-fold relative to radiation alone when administered at a dose of 60 mg/kg. VE-822 also enhances the tumoricidal effects of cisplatin (Item No. 13119) against primary human lung cancer xenografts and the effects of the topoisomerase inhibitor irinotecan (Item No. 14180) against COLO 205 colorectal tumors in mice.{36519,36518}
Brand:CaymanSKU:24198 - 50 mgAvailable on backorder
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. VE-cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton. It acts in concert with KRIT1 to establish and maintain correct endothelial cell polarity and vascular lumen. [Bertin Catalog No. A03144]
Brand:CaymanSKU:32754 - 100 µgAvailable on backorder
Brand:CaymanSKU:32754- 100 µgAvailable on backorder
Brand:CaymanSKU:32754- 100 µg
Immunogen: Recombinant VE-Cadherin fragment (amino acids 259-434) • Host: Rabbit • Species Reactivity: (+) Human, bovine, and mouse • Application(s): WB, ICC, and IP
Brand:CaymanSKU:160840- 500 µl VE-cadherin (vascular endothelium cadherin), also known as Cadherin-5, is an endothelial cell-specific adhesion molecule localized at intracellular junctions.{7201, 7068,7071} The protein belongs to the cadherin superfamily of adhesion molecules.{7072} VE-cadherin plays a pivotal role in vascular structure assembly. Endothelial cells fail to organize in a vessel-like pattern if the VE-cadherin gene is disrupted.{7069} In this aspect, VE-cadherin is a critical component of a protein complex which controls endothelial cell tube formation.{7070} VE-cadherin is also critical for maintenance of the endothelium. Following disruption of endothelial cell monolayers with an anti-VE-cadherin antibody, endothelial cells rapidly resynthesize VE-cadherin in order to restore their intracellular junctions.{6997} Human VE-cadherin has a molecular mass of approximately 87,500 based on the deduced amino acid sequence and is 83% and 79% homologous to porcine and mouse VE-cadherin at the amino acid level. Cayman’s VE-Cadherin Polyclonal Antibody can be used for immunocytochemistry, immunohistochemistry, immmunoprecipitation, and Western blot applications. The antibody recognizes VE-Cadherin at 88 kDa from human, bovine, and mouse samples.
Brand:CaymanSKU:160840 - 500 µlAvailable on backorder
Immunogen: Recombinant VE-Cadherin fragment (amino acids 259-434) • Host: Rabbit • Species Reactivity: (+) Human, bovine, and mouse • Application(s): WB, ICC, and IP
Brand:CaymanSKU:160840- 500 µlAvailable on backorder
Vecuronium is a non-depolarizing muscle relaxant derived from the aminosteroid pancuronium (Item No. 23778) and used adjunctively to general anesthesia.{25532} It competitively blocks cholinergic receptors at the motor end plate of the neuromuscular junction, inducing temporary paralysis.{25531} In humans, it has been shown to reduce muscle twitch tension with an ED50 value of 0.15 mg/kg for a duration of 27 minutes without inducing cardiovascular effects.{25532}
Brand:CaymanSKU:- Vecuronium is a non-depolarizing muscle relaxant derived from the aminosteroid pancuronium (Item No. 23778) and used adjunctively to general anesthesia.{25532} It competitively blocks cholinergic receptors at the motor end plate of the neuromuscular junction, inducing temporary paralysis.{25531} In humans, it has been shown to reduce muscle twitch tension with an ED50 value of 0.15 mg/kg for a duration of 27 minutes without inducing cardiovascular effects.{25532}
Brand:CaymanSKU:- Vecuronium is a non-depolarizing muscle relaxant derived from the aminosteroid pancuronium (Item No. 23778) and used adjunctively to general anesthesia.{25532} It competitively blocks cholinergic receptors at the motor end plate of the neuromuscular junction, inducing temporary paralysis.{25531} In humans, it has been shown to reduce muscle twitch tension with an ED50 value of 0.15 mg/kg for a duration of 27 minutes without inducing cardiovascular effects.{25532}
Brand:CaymanSKU:-
Vedaprofen is a non-steroidal anti-inflammatory drug (NSAID) commonly used in veterinary medicine to combat pain, inflammation, and fever associated with acute and chronic musculoskeletal disorders in horses and dogs.{30436} In addition to inhibiting COX and reducing prostaglandin H2 synthesis, vedaprofen is reported to block the activity of the E. coli DNA polymerase III β subunit, preventing DNA replication and repair.{34037}
Brand:CaymanSKU:- Vedaprofen is a non-steroidal anti-inflammatory drug (NSAID) commonly used in veterinary medicine to combat pain, inflammation, and fever associated with acute and chronic musculoskeletal disorders in horses and dogs.{30436} In addition to inhibiting COX and reducing prostaglandin H2 synthesis, vedaprofen is reported to block the activity of the E. coli DNA polymerase III β subunit, preventing DNA replication and repair.{34037}
Brand:CaymanSKU:- Vedaprofen is a non-steroidal anti-inflammatory drug (NSAID) commonly used in veterinary medicine to combat pain, inflammation, and fever associated with acute and chronic musculoskeletal disorders in horses and dogs.{30436} In addition to inhibiting COX and reducing prostaglandin H2 synthesis, vedaprofen is reported to block the activity of the E. coli DNA polymerase III β subunit, preventing DNA replication and repair.{34037}
Brand:CaymanSKU:-
VEGFR tyrosine kinase inhibitor II is a pyridinyl-anthranilamide compound that inhibits the kinase activities of VEGFR2 (KDR), VEGFR1 (FLT1), and c-Kit (IC50s = 20, 180, and 240 nM, respectively).{24344} It displays minimal activity against c-Src and EGFR (IC50s = 7 and 7.3 µM, respectively) and is inactive against Cdk1, c-Met, IGF-1R, and PKA (IC50s > 10 µM).{24344} VEGFR tyrosine kinase inhibitor II has been investigated for its potential to inhibit tumor induced angiogenesis.{24344}
Brand:CaymanSKU:-Available on backorder
VEGFR tyrosine kinase inhibitor II is a pyridinyl-anthranilamide compound that inhibits the kinase activities of VEGFR2 (KDR), VEGFR1 (FLT1), and c-Kit (IC50s = 20, 180, and 240 nM, respectively).{24344} It displays minimal activity against c-Src and EGFR (IC50s = 7 and 7.3 µM, respectively) and is inactive against Cdk1, c-Met, IGF-1R, and PKA (IC50s > 10 µM).{24344} VEGFR tyrosine kinase inhibitor II has been investigated for its potential to inhibit tumor induced angiogenesis.{24344}
Brand:CaymanSKU:-Available on backorder
Vascular endothelial growth factor receptor 2 (VEGFR2, also known as KDR and FLK1) is a receptor tyrosine kinase that regulates angiogenesis, vascular development, and embryonic hematopoiesis in response to VEGF isoforms A, C, and D. VEGFR2 kinase inhibitor I is a potent, cell-permeable inhibitor of mouse VEGFR2 kinase (IC50 = 70 nM).{28800} It has little or no effect against receptors for platelet-derived growth factor, epidermal growth factor, or insulin-like growth factor (IC50 > 100 µM).{28800}
Brand:CaymanSKU:- Vascular endothelial growth factor receptor 2 (VEGFR2, also known as KDR and FLK1) is a receptor tyrosine kinase that regulates angiogenesis, vascular development, and embryonic hematopoiesis in response to VEGF isoforms A, C, and D. VEGFR2 kinase inhibitor I is a potent, cell-permeable inhibitor of mouse VEGFR2 kinase (IC50 = 70 nM).{28800} It has little or no effect against receptors for platelet-derived growth factor, epidermal growth factor, or insulin-like growth factor (IC50 > 100 µM).{28800}
Brand:CaymanSKU:- Vascular endothelial growth factor receptor 2 (VEGFR2, also known as KDR and FLK1) is a receptor tyrosine kinase that regulates angiogenesis, vascular development, and embryonic hematopoiesis in response to VEGF isoforms A, C, and D. VEGFR2 kinase inhibitor I is a potent, cell-permeable inhibitor of mouse VEGFR2 kinase (IC50 = 70 nM).{28800} It has little or no effect against receptors for platelet-derived growth factor, epidermal growth factor, or insulin-like growth factor (IC50 > 100 µM).{28800}
Brand:CaymanSKU:- Vascular endothelial growth factor receptor 2 (VEGFR2, also known as KDR and FLK1) is a receptor tyrosine kinase that regulates angiogenesis, vascular development, and embryonic hematopoiesis in response to VEGF isoforms A, C, and D. VEGFR2 kinase inhibitor I is a potent, cell-permeable inhibitor of mouse VEGFR2 kinase (IC50 = 70 nM).{28800} It has little or no effect against receptors for platelet-derived growth factor, epidermal growth factor, or insulin-like growth factor (IC50 > 100 µM).{28800}
Brand:CaymanSKU:-
Vascular endothelial growth factor receptor 2 (VEGFR2, also known as KDR and FLK1) is a receptor tyrosine kinase that regulates angiogenesis, vascular development, and embryonic hematopoiesis in response to VEGF isoforms A, C, and D. VEGFR2 kinase inhibitor II is a reversible, cell-permeable inhibitor of VEGFR2’s kinase activity (IC50 = 70 nM).{28749} It less potently inhibits the platelet-derived growth factor receptor β (PDGFRβ; IC50 = 920 nM) and related receptor and non-receptor tyrosine kinases.{28749} VEGFR2 kinase inhibitor II blocks the growth of human umbilical vein endothelial cells stimulated with either VEGF or PDGF (IC50s = 110 nM and 2 µM, respectively).{28749}
Brand:CaymanSKU:-Available on backorder
Vascular endothelial growth factor receptor 2 (VEGFR2, also known as KDR and FLK1) is a receptor tyrosine kinase that regulates angiogenesis, vascular development, and embryonic hematopoiesis in response to VEGF isoforms A, C, and D. VEGFR2 kinase inhibitor II is a reversible, cell-permeable inhibitor of VEGFR2’s kinase activity (IC50 = 70 nM).{28749} It less potently inhibits the platelet-derived growth factor receptor β (PDGFRβ; IC50 = 920 nM) and related receptor and non-receptor tyrosine kinases.{28749} VEGFR2 kinase inhibitor II blocks the growth of human umbilical vein endothelial cells stimulated with either VEGF or PDGF (IC50s = 110 nM and 2 µM, respectively).{28749}
Brand:CaymanSKU:-Available on backorder
Vascular endothelial growth factor receptor 2 (VEGFR2, also known as KDR and FLK1) is a receptor tyrosine kinase that regulates angiogenesis, vascular development, and embryonic hematopoiesis in response to VEGF isoforms A, C, and D. VEGFR2 kinase inhibitor II is a reversible, cell-permeable inhibitor of VEGFR2’s kinase activity (IC50 = 70 nM).{28749} It less potently inhibits the platelet-derived growth factor receptor β (PDGFRβ; IC50 = 920 nM) and related receptor and non-receptor tyrosine kinases.{28749} VEGFR2 kinase inhibitor II blocks the growth of human umbilical vein endothelial cells stimulated with either VEGF or PDGF (IC50s = 110 nM and 2 µM, respectively).{28749}
Brand:CaymanSKU:-Available on backorder
Velpatasvir is a second generation direct-acting inhibitor of NS5A, a non-structural protein required for replication of the hepatitis C virus (HCV).{33519} It has broad antiviral activity in vitro against the HCV strain subtypes 1a, 1b, 2a, 2b, 3a, 4a, 5a, 6a, and 6e (EC50 = 6-130 pM).{33517} A phase 1 clinical trial concluded that once daily doses of velpatasvir from 5-150 mg were well tolerated and provided significant viral reduction.{33518}
Brand:CaymanSKU:21280 -Out of stock
Velpatasvir is a second generation direct-acting inhibitor of NS5A, a non-structural protein required for replication of the hepatitis C virus (HCV).{33519} It has broad antiviral activity in vitro against the HCV strain subtypes 1a, 1b, 2a, 2b, 3a, 4a, 5a, 6a, and 6e (EC50 = 6-130 pM).{33517} A phase 1 clinical trial concluded that once daily doses of velpatasvir from 5-150 mg were well tolerated and provided significant viral reduction.{33518}
Brand:CaymanSKU:21280 -Out of stock
Velpatasvir is a second generation direct-acting inhibitor of NS5A, a non-structural protein required for replication of the hepatitis C virus (HCV).{33519} It has broad antiviral activity in vitro against the HCV strain subtypes 1a, 1b, 2a, 2b, 3a, 4a, 5a, 6a, and 6e (EC50 = 6-130 pM).{33517} A phase 1 clinical trial concluded that once daily doses of velpatasvir from 5-150 mg were well tolerated and provided significant viral reduction.{33518}
Brand:CaymanSKU:21280 -Out of stock
Velpatasvir is a second generation direct-acting inhibitor of NS5A, a non-structural protein required for replication of the hepatitis C virus (HCV).{33519} It has broad antiviral activity in vitro against the HCV strain subtypes 1a, 1b, 2a, 2b, 3a, 4a, 5a, 6a, and 6e (EC50 = 6-130 pM).{33517} A phase 1 clinical trial concluded that once daily doses of velpatasvir from 5-150 mg were well tolerated and provided significant viral reduction.{33518}
Brand:CaymanSKU:21280 -Out of stock
Venturicidin A is a macrolide antibiotic isolated from strains of Streptomyces.{24920} It is active against fungi in the genus Venturia which cause apple scab, as well as other fungi, but not against higher plants.{24920} Venturicidin A is also cytotoxic against trypanosomes (IC50 = 120-540 ng/ml) while being more than 25,000 times less effective against mammalian cells.{24919} It inhibits bacterial and mitochondrial ATP synthases.{24921,24918}
Brand:CaymanSKU:- Venturicidin A is a macrolide antibiotic isolated from strains of Streptomyces.{24920} It is active against fungi in the genus Venturia which cause apple scab, as well as other fungi, but not against higher plants.{24920} Venturicidin A is also cytotoxic against trypanosomes (IC50 = 120-540 ng/ml) while being more than 25,000 times less effective against mammalian cells.{24919} It inhibits bacterial and mitochondrial ATP synthases.{24921,24918}
Brand:CaymanSKU:-
Brand:CaymanSKU:25478 - 1 mgAvailable on backorder
Brand:CaymanSKU:25478 - 250 µgAvailable on backorder
VER-155008 is an adenosine-derived inhibitor of heat shock protein 70 (Hsp70; IC50 = 0.5 µM) that is selective over Hsp90.{28942} It targets the nucleotide-binding domain (NBD) of Hsp70 and similarly binds the NBDs of Hsp70 cognates Hsc70 (Ki = 10 µM) and glucose-regulated protein 78 (Grp78; KD = 80 nM).{28941,28939} VER-155008 inhibits the proliferation of human breast and colon cancer cell lines, inducing apoptosis or caspase-independent cell death.{28940} It induces the proteasome-dependent degradation of Hsp90 client proteins and potentiates the apoptotic activity of Hsp90 inhibitors.{28942,28940} VER-15508 also triggers paraptosis in anaplastic thyroid carcinoma cells.{28938}
Brand:CaymanSKU:-Out of stock
VER-155008 is an adenosine-derived inhibitor of heat shock protein 70 (Hsp70; IC50 = 0.5 µM) that is selective over Hsp90.{28942} It targets the nucleotide-binding domain (NBD) of Hsp70 and similarly binds the NBDs of Hsp70 cognates Hsc70 (Ki = 10 µM) and glucose-regulated protein 78 (Grp78; KD = 80 nM).{28941,28939} VER-155008 inhibits the proliferation of human breast and colon cancer cell lines, inducing apoptosis or caspase-independent cell death.{28940} It induces the proteasome-dependent degradation of Hsp90 client proteins and potentiates the apoptotic activity of Hsp90 inhibitors.{28942,28940} VER-15508 also triggers paraptosis in anaplastic thyroid carcinoma cells.{28938}
Brand:CaymanSKU:-Out of stock
VER-155008 is an adenosine-derived inhibitor of heat shock protein 70 (Hsp70; IC50 = 0.5 µM) that is selective over Hsp90.{28942} It targets the nucleotide-binding domain (NBD) of Hsp70 and similarly binds the NBDs of Hsp70 cognates Hsc70 (Ki = 10 µM) and glucose-regulated protein 78 (Grp78; KD = 80 nM).{28941,28939} VER-155008 inhibits the proliferation of human breast and colon cancer cell lines, inducing apoptosis or caspase-independent cell death.{28940} It induces the proteasome-dependent degradation of Hsp90 client proteins and potentiates the apoptotic activity of Hsp90 inhibitors.{28942,28940} VER-15508 also triggers paraptosis in anaplastic thyroid carcinoma cells.{28938}
Brand:CaymanSKU:-Out of stock
VER-155008 is an adenosine-derived inhibitor of heat shock protein 70 (Hsp70; IC50 = 0.5 µM) that is selective over Hsp90.{28942} It targets the nucleotide-binding domain (NBD) of Hsp70 and similarly binds the NBDs of Hsp70 cognates Hsc70 (Ki = 10 µM) and glucose-regulated protein 78 (Grp78; KD = 80 nM).{28941,28939} VER-155008 inhibits the proliferation of human breast and colon cancer cell lines, inducing apoptosis or caspase-independent cell death.{28940} It induces the proteasome-dependent degradation of Hsp90 client proteins and potentiates the apoptotic activity of Hsp90 inhibitors.{28942,28940} VER-15508 also triggers paraptosis in anaplastic thyroid carcinoma cells.{28938}
Brand:CaymanSKU:-Out of stock
The heat shock proteins (Hsps) act as molecular chaperones. Hsp90 is an abundant protein with roles in protein folding, cell signaling, and cancer. VER-49009 is a pyrazole compound that inhibits Hsp90 with an IC50 value of 47 nM.{16496} It produces a cellular antiproliferative GI50 value of 685 nM when tested against a human cancer cell line panel.{16496} Consistent with inhibition of Hsp90, VER-49009 induces the expression of Hsp27 and Hsp72 while reducing the client proteins c-Raf, B-Raf, survivin, and PRMT5, causing cell cycle arrest and apoptosis.{16496}
Brand:CaymanSKU:- The heat shock proteins (Hsps) act as molecular chaperones. Hsp90 is an abundant protein with roles in protein folding, cell signaling, and cancer. VER-49009 is a pyrazole compound that inhibits Hsp90 with an IC50 value of 47 nM.{16496} It produces a cellular antiproliferative GI50 value of 685 nM when tested against a human cancer cell line panel.{16496} Consistent with inhibition of Hsp90, VER-49009 induces the expression of Hsp27 and Hsp72 while reducing the client proteins c-Raf, B-Raf, survivin, and PRMT5, causing cell cycle arrest and apoptosis.{16496}
Brand:CaymanSKU:- The heat shock proteins (Hsps) act as molecular chaperones. Hsp90 is an abundant protein with roles in protein folding, cell signaling, and cancer. VER-49009 is a pyrazole compound that inhibits Hsp90 with an IC50 value of 47 nM.{16496} It produces a cellular antiproliferative GI50 value of 685 nM when tested against a human cancer cell line panel.{16496} Consistent with inhibition of Hsp90, VER-49009 induces the expression of Hsp27 and Hsp72 while reducing the client proteins c-Raf, B-Raf, survivin, and PRMT5, causing cell cycle arrest and apoptosis.{16496}
Brand:CaymanSKU:- The heat shock proteins (Hsps) act as molecular chaperones. Hsp90 is an abundant protein with roles in protein folding, cell signaling, and cancer. VER-49009 is a pyrazole compound that inhibits Hsp90 with an IC50 value of 47 nM.{16496} It produces a cellular antiproliferative GI50 value of 685 nM when tested against a human cancer cell line panel.{16496} Consistent with inhibition of Hsp90, VER-49009 induces the expression of Hsp27 and Hsp72 while reducing the client proteins c-Raf, B-Raf, survivin, and PRMT5, causing cell cycle arrest and apoptosis.{16496}
Brand:CaymanSKU:-
The heat shock proteins (Hsps) act as molecular chaperones. Hsp90 is an abundant protein with roles in protein folding, cell signaling, and cancer. VER-50589 is an isoxazole compound that inhibits Hsp90 with an IC50 value of 21 nM.{16496} It produces a mean cellular antiproliferative GI50 value of 78 nM when tested against a human cancer cell line panel.{16496} Consistent with inhibition of Hsp90, VER-50589 induces the expression of Hsp27 and Hsp72 while reducing the client proteins C-RAF, B-RAF, survivin, and PRMT5, causing cell cycle arrest and apoptosis.{16496} VER-50589 shows favorable pharmacokinetics and impairs tumor growth in animals.{16496} Importantly, glioblastoma cells do not acquire resistance to VER-50589 and resistance to other Hsp90 inhibitors does not produce cross-resistance to VER-50589.{17993}
Brand:CaymanSKU:- The heat shock proteins (Hsps) act as molecular chaperones. Hsp90 is an abundant protein with roles in protein folding, cell signaling, and cancer. VER-50589 is an isoxazole compound that inhibits Hsp90 with an IC50 value of 21 nM.{16496} It produces a mean cellular antiproliferative GI50 value of 78 nM when tested against a human cancer cell line panel.{16496} Consistent with inhibition of Hsp90, VER-50589 induces the expression of Hsp27 and Hsp72 while reducing the client proteins C-RAF, B-RAF, survivin, and PRMT5, causing cell cycle arrest and apoptosis.{16496} VER-50589 shows favorable pharmacokinetics and impairs tumor growth in animals.{16496} Importantly, glioblastoma cells do not acquire resistance to VER-50589 and resistance to other Hsp90 inhibitors does not produce cross-resistance to VER-50589.{17993}
Brand:CaymanSKU:- The heat shock proteins (Hsps) act as molecular chaperones. Hsp90 is an abundant protein with roles in protein folding, cell signaling, and cancer. VER-50589 is an isoxazole compound that inhibits Hsp90 with an IC50 value of 21 nM.{16496} It produces a mean cellular antiproliferative GI50 value of 78 nM when tested against a human cancer cell line panel.{16496} Consistent with inhibition of Hsp90, VER-50589 induces the expression of Hsp27 and Hsp72 while reducing the client proteins C-RAF, B-RAF, survivin, and PRMT5, causing cell cycle arrest and apoptosis.{16496} VER-50589 shows favorable pharmacokinetics and impairs tumor growth in animals.{16496} Importantly, glioblastoma cells do not acquire resistance to VER-50589 and resistance to other Hsp90 inhibitors does not produce cross-resistance to VER-50589.{17993}
Brand:CaymanSKU:-
Verapamil is the prototypical blocker of L-type calcium channels that produces excitation-contraction uncoupling in cardiac muscle by preventing the slow-inward current of calcium ions.{22485} Verapamil can also block calcium fluxes in vascular smooth muscle. It has both peripheral and coronary vasodilator effects (IC50 = 0.38 μM in guinea pig aortic strip) and has been used to control hypertension, angina, cardiac arrhythmia, and vascular headaches.{22481,22479,22478} Verapamil has also been used in cell biology as an inhibitor of drug efflux pump proteins such as P-glycoprotein, which are often over-expressed in certain tumor cell lines.{20755}
Brand:CaymanSKU:- Verapamil is the prototypical blocker of L-type calcium channels that produces excitation-contraction uncoupling in cardiac muscle by preventing the slow-inward current of calcium ions.{22485} Verapamil can also block calcium fluxes in vascular smooth muscle. It has both peripheral and coronary vasodilator effects (IC50 = 0.38 μM in guinea pig aortic strip) and has been used to control hypertension, angina, cardiac arrhythmia, and vascular headaches.{22481,22479,22478} Verapamil has also been used in cell biology as an inhibitor of drug efflux pump proteins such as P-glycoprotein, which are often over-expressed in certain tumor cell lines.{20755}
Brand:CaymanSKU:- Verapamil is the prototypical blocker of L-type calcium channels that produces excitation-contraction uncoupling in cardiac muscle by preventing the slow-inward current of calcium ions.{22485} Verapamil can also block calcium fluxes in vascular smooth muscle. It has both peripheral and coronary vasodilator effects (IC50 = 0.38 μM in guinea pig aortic strip) and has been used to control hypertension, angina, cardiac arrhythmia, and vascular headaches.{22481,22479,22478} Verapamil has also been used in cell biology as an inhibitor of drug efflux pump proteins such as P-glycoprotein, which are often over-expressed in certain tumor cell lines.{20755}
Brand:CaymanSKU:-
The hedgehog (Hh) signaling pathway, which is blocked by cyclopamine (Item No. 11321), plays a key role in morphogenesis and has potential applications in the treatment of cancer.{20489,20491,18038} Veratramine, a teratogenic steroidal alkaloid isolated from the corn lily (Veratrum sp.), is an analog of cyclopamine that can inhibit the Hh signaling-dependent proliferation of NIH/3T3 cells at 8 μM.{21777} Additionally, veratramine has anti-thrombotic activity as it dose dependently inhibits platelet aggregation in rabbits ex vivo. While it may be most useful as a signal transduction inhibitor for treating tumors, veratramine also induces serotonin release and inhibits its re-uptake in the CNS.{21779,21778}
Brand:CaymanSKU:11724 - 10 mgAvailable on backorder
The hedgehog (Hh) signaling pathway, which is blocked by cyclopamine (Item No. 11321), plays a key role in morphogenesis and has potential applications in the treatment of cancer.{20489,20491,18038} Veratramine, a teratogenic steroidal alkaloid isolated from the corn lily (Veratrum sp.), is an analog of cyclopamine that can inhibit the Hh signaling-dependent proliferation of NIH/3T3 cells at 8 μM.{21777} Additionally, veratramine has anti-thrombotic activity as it dose dependently inhibits platelet aggregation in rabbits ex vivo. While it may be most useful as a signal transduction inhibitor for treating tumors, veratramine also induces serotonin release and inhibits its re-uptake in the CNS.{21779,21778}
Brand:CaymanSKU:11724 - 25 mgAvailable on backorder
The hedgehog (Hh) signaling pathway, which is blocked by cyclopamine (Item No. 11321), plays a key role in morphogenesis and has potential applications in the treatment of cancer.{20489,20491,18038} Veratramine, a teratogenic steroidal alkaloid isolated from the corn lily (Veratrum sp.), is an analog of cyclopamine that can inhibit the Hh signaling-dependent proliferation of NIH/3T3 cells at 8 μM.{21777} Additionally, veratramine has anti-thrombotic activity as it dose dependently inhibits platelet aggregation in rabbits ex vivo. While it may be most useful as a signal transduction inhibitor for treating tumors, veratramine also induces serotonin release and inhibits its re-uptake in the CNS.{21779,21778}
Brand:CaymanSKU:11724 - 5 mgAvailable on backorder
The hedgehog (Hh) signaling pathway, which is blocked by cyclopamine (Item No. 11321), plays a key role in morphogenesis and has potential applications in the treatment of cancer.{20489,20491,18038} Veratramine, a teratogenic steroidal alkaloid isolated from the corn lily (Veratrum sp.), is an analog of cyclopamine that can inhibit the Hh signaling-dependent proliferation of NIH/3T3 cells at 8 μM.{21777} Additionally, veratramine has anti-thrombotic activity as it dose dependently inhibits platelet aggregation in rabbits ex vivo. While it may be most useful as a signal transduction inhibitor for treating tumors, veratramine also induces serotonin release and inhibits its re-uptake in the CNS.{21779,21778}
Brand:CaymanSKU:11724 - 50 mgAvailable on backorder
Verbascoside is a natural phenylpropanoid glucoside that has been found in a variety of plants, including B. cordata, B. officinalis, and S. vulgaris, and has diverse biological activities.{42167,42168,42171,42169,42170} Verbascoside is a PKC inhibitor (IC50 = 25 μM).{42168} It inhibits the growth of Gram-positive and Gram-negative bacteria with MIC values ranging from 4 to 128 μg/ml including S. aureus and E. coli (MICs = 16 and 32 μg/ml, respectively).{42171} Verbascoside (0.1-10 μg/ml) dose-dependently reduces extracellular hydrogen peroxide concentrations and increases cell viability of PC12 cells following 1-methyl-4-phenylpyridinium ion (MPP+) administration to induce apoptosis and oxidative stress.{42167} It also inhibits the growth of MGC803 human gastric adenocarcinoma cells in a dose-dependent manner when used at concentrations ranging from 10 to 20 μM with maximal growth inhibition of 53%.{42169} In a rat model of colitis induced by 2,4-dinitrobenzene sulfonic acid (DNBS), verbascoside (0.2-2 mg/kg) reduces colon damage and the expression of TNF-α, IL-1β, and inducible nitric oxide synthase (iNOS).{42170}
Brand:CaymanSKU:24965 - 1 mgAvailable on backorder
Verbascoside is a natural phenylpropanoid glucoside that has been found in a variety of plants, including B. cordata, B. officinalis, and S. vulgaris, and has diverse biological activities.{42167,42168,42171,42169,42170} Verbascoside is a PKC inhibitor (IC50 = 25 μM).{42168} It inhibits the growth of Gram-positive and Gram-negative bacteria with MIC values ranging from 4 to 128 μg/ml including S. aureus and E. coli (MICs = 16 and 32 μg/ml, respectively).{42171} Verbascoside (0.1-10 μg/ml) dose-dependently reduces extracellular hydrogen peroxide concentrations and increases cell viability of PC12 cells following 1-methyl-4-phenylpyridinium ion (MPP+) administration to induce apoptosis and oxidative stress.{42167} It also inhibits the growth of MGC803 human gastric adenocarcinoma cells in a dose-dependent manner when used at concentrations ranging from 10 to 20 μM with maximal growth inhibition of 53%.{42169} In a rat model of colitis induced by 2,4-dinitrobenzene sulfonic acid (DNBS), verbascoside (0.2-2 mg/kg) reduces colon damage and the expression of TNF-α, IL-1β, and inducible nitric oxide synthase (iNOS).{42170}
Brand:CaymanSKU:24965 - 10 mgAvailable on backorder
Verbascoside is a natural phenylpropanoid glucoside that has been found in a variety of plants, including B. cordata, B. officinalis, and S. vulgaris, and has diverse biological activities.{42167,42168,42171,42169,42170} Verbascoside is a PKC inhibitor (IC50 = 25 μM).{42168} It inhibits the growth of Gram-positive and Gram-negative bacteria with MIC values ranging from 4 to 128 μg/ml including S. aureus and E. coli (MICs = 16 and 32 μg/ml, respectively).{42171} Verbascoside (0.1-10 μg/ml) dose-dependently reduces extracellular hydrogen peroxide concentrations and increases cell viability of PC12 cells following 1-methyl-4-phenylpyridinium ion (MPP+) administration to induce apoptosis and oxidative stress.{42167} It also inhibits the growth of MGC803 human gastric adenocarcinoma cells in a dose-dependent manner when used at concentrations ranging from 10 to 20 μM with maximal growth inhibition of 53%.{42169} In a rat model of colitis induced by 2,4-dinitrobenzene sulfonic acid (DNBS), verbascoside (0.2-2 mg/kg) reduces colon damage and the expression of TNF-α, IL-1β, and inducible nitric oxide synthase (iNOS).{42170}
Brand:CaymanSKU:24965 - 25 mgAvailable on backorder
Verbascoside is a natural phenylpropanoid glucoside that has been found in a variety of plants, including B. cordata, B. officinalis, and S. vulgaris, and has diverse biological activities.{42167,42168,42171,42169,42170} Verbascoside is a PKC inhibitor (IC50 = 25 μM).{42168} It inhibits the growth of Gram-positive and Gram-negative bacteria with MIC values ranging from 4 to 128 μg/ml including S. aureus and E. coli (MICs = 16 and 32 μg/ml, respectively).{42171} Verbascoside (0.1-10 μg/ml) dose-dependently reduces extracellular hydrogen peroxide concentrations and increases cell viability of PC12 cells following 1-methyl-4-phenylpyridinium ion (MPP+) administration to induce apoptosis and oxidative stress.{42167} It also inhibits the growth of MGC803 human gastric adenocarcinoma cells in a dose-dependent manner when used at concentrations ranging from 10 to 20 μM with maximal growth inhibition of 53%.{42169} In a rat model of colitis induced by 2,4-dinitrobenzene sulfonic acid (DNBS), verbascoside (0.2-2 mg/kg) reduces colon damage and the expression of TNF-α, IL-1β, and inducible nitric oxide synthase (iNOS).{42170}
Brand:CaymanSKU:24965 - 5 mgAvailable on backorder
Vercirnon is an orally bioavailable antagonist of chemokine receptor 9 (CCR9) with an IC50 value of 5.4 nM for inhibition of CCL25-induced calcium mobilization in Molt-4 cells.{47155} It is selective for CCR9 over CCR1-12 and CX3CR1-7 (IC50s = >10 µM for all). It also inhibits CCL25-induced Molt-4 chemotaxis in 0.1% BSA/HBSS and in 100% human AB serum (IC50s = 3.5 and 33.4 nM, respectively), as well as chemotaxis of human T cells stimulated by retinoic acid (RA) and mouse and rat thymocytes. Vercirnon binds allosterically to the intracellular side of CCR9 and prevents G protein coupling.{47156}
Brand:CaymanSKU:23131 - 1 mgAvailable on backorder
Vercirnon is an orally bioavailable antagonist of chemokine receptor 9 (CCR9) with an IC50 value of 5.4 nM for inhibition of CCL25-induced calcium mobilization in Molt-4 cells.{47155} It is selective for CCR9 over CCR1-12 and CX3CR1-7 (IC50s = >10 µM for all). It also inhibits CCL25-induced Molt-4 chemotaxis in 0.1% BSA/HBSS and in 100% human AB serum (IC50s = 3.5 and 33.4 nM, respectively), as well as chemotaxis of human T cells stimulated by retinoic acid (RA) and mouse and rat thymocytes. Vercirnon binds allosterically to the intracellular side of CCR9 and prevents G protein coupling.{47156}
Brand:CaymanSKU:23131 - 5 mgAvailable on backorder
Verdinexor is a reversible inhibitor of Exportin I (XPO1/CRM1) with anticancer and antiviral activities.{48116,48117,48118} It inhibits the growth of OCI-Ly3, OCI-Ly10, and CLBL1 diffuse large B cell lymphoma (DLBCL) cells (IC50s = 2.1, 41.8, and 8.5 nM, respectively).{48116} Verdinexor inhibits XPO1/CRM1-mediated nuclear transport of respiratory syncytial virus (RSV) M protein when used at concentrations greater than 1 μM.{48117} It reduces RSV A2 replication (IC50 = 0.96 μM) without affecting viability of A549 cells (CC50 = >38 μM). In vivo, verdinexor (20 mg/kg) reduces virus shedding, pulmonary TNF-α, IL-6, MCP-1, and IFN-γ expression, and leukocyte infiltration into the bronchoalveolar space in a mouse model of influenza A viral infection.{48118} It also reduces viral burden in a ferret model of influenza A viral infection.
Brand:CaymanSKU:26171 - 1 mgAvailable on backorder