Cayman
Showing 43351–43500 of 45550 results
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UNC2327 is an allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3; IC50 = 230 nM).{30116}
Brand:CaymanSKU:-Available on backorder
UNC2327 is an allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3; IC50 = 230 nM).{30116}
Brand:CaymanSKU:-Available on backorder
UNC2327 is an allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3; IC50 = 230 nM).{30116}
Brand:CaymanSKU:-Available on backorder
UNC2881 is an inhibitor of Mer (IC50 = 4.3 nM), a member of the TAM family of receptor tyrosine kinases.{45606} It is selective for Mer over the remaining TAM family members Axl and TYRO3 (IC50s = 360 and 250 nM, respectively). UNC2881 inhibits phosphorylation of Mer in 697 B-ALL acute lymphoblastic leukemia cells (IC50 = 21.9 nM). It inhibits platelet aggregation and ATP release induced by type I equine fibrillar collagen in isolated human platelet-rich plasma when used at a concentration of 3 μM.
Brand:CaymanSKU:29012 - 10 mgAvailable on backorder
UNC2881 is an inhibitor of Mer (IC50 = 4.3 nM), a member of the TAM family of receptor tyrosine kinases.{45606} It is selective for Mer over the remaining TAM family members Axl and TYRO3 (IC50s = 360 and 250 nM, respectively). UNC2881 inhibits phosphorylation of Mer in 697 B-ALL acute lymphoblastic leukemia cells (IC50 = 21.9 nM). It inhibits platelet aggregation and ATP release induced by type I equine fibrillar collagen in isolated human platelet-rich plasma when used at a concentration of 3 μM.
Brand:CaymanSKU:29012 - 25 mgAvailable on backorder
UNC2881 is an inhibitor of Mer (IC50 = 4.3 nM), a member of the TAM family of receptor tyrosine kinases.{45606} It is selective for Mer over the remaining TAM family members Axl and TYRO3 (IC50s = 360 and 250 nM, respectively). UNC2881 inhibits phosphorylation of Mer in 697 B-ALL acute lymphoblastic leukemia cells (IC50 = 21.9 nM). It inhibits platelet aggregation and ATP release induced by type I equine fibrillar collagen in isolated human platelet-rich plasma when used at a concentration of 3 μM.
Brand:CaymanSKU:29012 - 5 mgAvailable on backorder
UNC2881 is an inhibitor of Mer (IC50 = 4.3 nM), a member of the TAM family of receptor tyrosine kinases.{45606} It is selective for Mer over the remaining TAM family members Axl and TYRO3 (IC50s = 360 and 250 nM, respectively). UNC2881 inhibits phosphorylation of Mer in 697 B-ALL acute lymphoblastic leukemia cells (IC50 = 21.9 nM). It inhibits platelet aggregation and ATP release induced by type I equine fibrillar collagen in isolated human platelet-rich plasma when used at a concentration of 3 μM.
Brand:CaymanSKU:29012 - 50 mgAvailable on backorder
Phosphatidylinositol-4-phosphate 5-kinase type-1 γ (PIP5K1C) is a lipid kinase that generates phosphatidylinositol-4,5-bisphosphate (PIP2) in nociceptive dorsal root ganglia (DRG).{26548} Pain sensitization is regulated by multiple signaling pathways that are initiated by phospholipase C-mediated hydrolysis of PIP2.{26548} UNC3230 is a small molecule inhibitor of PIP5K1C (IC50 = 41 nM, Kd = 51 nM).{26548} It does not inhibit any other lipid kinases that regulate phosphoinositide levels, including phosphatidylinositol 3-kinases.{26548} At 100 nM, UNC3230 decreases PIP2 membrane levels in cultured DRG neurons by 45% and significantly reduces calcium signaling. At 2 nM, it displays antinociceptive effects in mouse models of chronic pain when administered intrathecally or injected into inflamed hindpaw.{26548}
Brand:CaymanSKU:-Out of stock
Phosphatidylinositol-4-phosphate 5-kinase type-1 γ (PIP5K1C) is a lipid kinase that generates phosphatidylinositol-4,5-bisphosphate (PIP2) in nociceptive dorsal root ganglia (DRG).{26548} Pain sensitization is regulated by multiple signaling pathways that are initiated by phospholipase C-mediated hydrolysis of PIP2.{26548} UNC3230 is a small molecule inhibitor of PIP5K1C (IC50 = 41 nM, Kd = 51 nM).{26548} It does not inhibit any other lipid kinases that regulate phosphoinositide levels, including phosphatidylinositol 3-kinases.{26548} At 100 nM, UNC3230 decreases PIP2 membrane levels in cultured DRG neurons by 45% and significantly reduces calcium signaling. At 2 nM, it displays antinociceptive effects in mouse models of chronic pain when administered intrathecally or injected into inflamed hindpaw.{26548}
Brand:CaymanSKU:-Out of stock
Phosphatidylinositol-4-phosphate 5-kinase type-1 γ (PIP5K1C) is a lipid kinase that generates phosphatidylinositol-4,5-bisphosphate (PIP2) in nociceptive dorsal root ganglia (DRG).{26548} Pain sensitization is regulated by multiple signaling pathways that are initiated by phospholipase C-mediated hydrolysis of PIP2.{26548} UNC3230 is a small molecule inhibitor of PIP5K1C (IC50 = 41 nM, Kd = 51 nM).{26548} It does not inhibit any other lipid kinases that regulate phosphoinositide levels, including phosphatidylinositol 3-kinases.{26548} At 100 nM, UNC3230 decreases PIP2 membrane levels in cultured DRG neurons by 45% and significantly reduces calcium signaling. At 2 nM, it displays antinociceptive effects in mouse models of chronic pain when administered intrathecally or injected into inflamed hindpaw.{26548}
Brand:CaymanSKU:-Out of stock
Phosphatidylinositol-4-phosphate 5-kinase type-1 γ (PIP5K1C) is a lipid kinase that generates phosphatidylinositol-4,5-bisphosphate (PIP2) in nociceptive dorsal root ganglia (DRG).{26548} Pain sensitization is regulated by multiple signaling pathways that are initiated by phospholipase C-mediated hydrolysis of PIP2.{26548} UNC3230 is a small molecule inhibitor of PIP5K1C (IC50 = 41 nM, Kd = 51 nM).{26548} It does not inhibit any other lipid kinases that regulate phosphoinositide levels, including phosphatidylinositol 3-kinases.{26548} At 100 nM, UNC3230 decreases PIP2 membrane levels in cultured DRG neurons by 45% and significantly reduces calcium signaling. At 2 nM, it displays antinociceptive effects in mouse models of chronic pain when administered intrathecally or injected into inflamed hindpaw.{26548}
Brand:CaymanSKU:-Out of stock
UNC3866 is an inhibitor of chromobox homolog 7 (CBX7; Kd = 97 nM).{30607} It also binds to CBX4 (Kd = 94 nM) but is greater than 6-fold selective over CBX2, 6, and 8 and the chromodomain Y family (CDY) chromodomains CDY1, L1b, and L2 (Kds = 0.61-6.3 μM). UNC3866 pretreatment (30 μM) of PC3 lysates completely inhibits chemiprecipitation of CBX7. It induces a senescent-like morphology and reduces growth of PC3 cells with an EC50 value of 7.6 μM.
Brand:CaymanSKU:-Available on backorder
UNC3866 is an inhibitor of chromobox homolog 7 (CBX7; Kd = 97 nM).{30607} It also binds to CBX4 (Kd = 94 nM) but is greater than 6-fold selective over CBX2, 6, and 8 and the chromodomain Y family (CDY) chromodomains CDY1, L1b, and L2 (Kds = 0.61-6.3 μM). UNC3866 pretreatment (30 μM) of PC3 lysates completely inhibits chemiprecipitation of CBX7. It induces a senescent-like morphology and reduces growth of PC3 cells with an EC50 value of 7.6 μM.
Brand:CaymanSKU:-Available on backorder
UNC3866 is an inhibitor of chromobox homolog 7 (CBX7; Kd = 97 nM).{30607} It also binds to CBX4 (Kd = 94 nM) but is greater than 6-fold selective over CBX2, 6, and 8 and the chromodomain Y family (CDY) chromodomains CDY1, L1b, and L2 (Kds = 0.61-6.3 μM). UNC3866 pretreatment (30 μM) of PC3 lysates completely inhibits chemiprecipitation of CBX7. It induces a senescent-like morphology and reduces growth of PC3 cells with an EC50 value of 7.6 μM.
Brand:CaymanSKU:-Available on backorder
UNC3866 is an inhibitor of chromobox homolog 7 (CBX7; Kd = 97 nM).{30607} It also binds to CBX4 (Kd = 94 nM) but is greater than 6-fold selective over CBX2, 6, and 8 and the chromodomain Y family (CDY) chromodomains CDY1, L1b, and L2 (Kds = 0.61-6.3 μM). UNC3866 pretreatment (30 μM) of PC3 lysates completely inhibits chemiprecipitation of CBX7. It induces a senescent-like morphology and reduces growth of PC3 cells with an EC50 value of 7.6 μM.
Brand:CaymanSKU:-Available on backorder
UNC569 is a potent inhibitor of the TAM family receptor tyrosine kinases Mer, Axl, and Tyro3 (IC50s = 2.9, 37, and 48 nM, respectively).{41372} It has antiproliferative activity in vitro against acute lymphoblastic leukemia (ALL) cells (IC50s = 0.5 and 1.2 μM for 697 and Jurkat cell lines, respectively) and inhibits Mer phosphorylation (IC50s = 141 and 193 nM in 697 and Jurkat cell lines, respectively). UNC569 activates Akt and ERK1/2 phosphorylation, induces apoptosis, and sensitizes ALL cells to etoposide (Item No. 12092) and methotrexate (Item No. 13960). In vivo, UNC569 (4 μM) decreases tumor burden by 47.8% relative to vehicle controls in human MYC transgenic zebrafish. UNC569 (10 mg/kg) delays leukemia onset, reduces CNS infiltration, and prolongs survival of mice implanted with patient-derived Mer-expressing ALL primary cells.{41373}
Brand:CaymanSKU:22966 - 1 mgAvailable on backorder
UNC569 is a potent inhibitor of the TAM family receptor tyrosine kinases Mer, Axl, and Tyro3 (IC50s = 2.9, 37, and 48 nM, respectively).{41372} It has antiproliferative activity in vitro against acute lymphoblastic leukemia (ALL) cells (IC50s = 0.5 and 1.2 μM for 697 and Jurkat cell lines, respectively) and inhibits Mer phosphorylation (IC50s = 141 and 193 nM in 697 and Jurkat cell lines, respectively). UNC569 activates Akt and ERK1/2 phosphorylation, induces apoptosis, and sensitizes ALL cells to etoposide (Item No. 12092) and methotrexate (Item No. 13960). In vivo, UNC569 (4 μM) decreases tumor burden by 47.8% relative to vehicle controls in human MYC transgenic zebrafish. UNC569 (10 mg/kg) delays leukemia onset, reduces CNS infiltration, and prolongs survival of mice implanted with patient-derived Mer-expressing ALL primary cells.{41373}
Brand:CaymanSKU:22966 - 10 mgAvailable on backorder
UNC569 is a potent inhibitor of the TAM family receptor tyrosine kinases Mer, Axl, and Tyro3 (IC50s = 2.9, 37, and 48 nM, respectively).{41372} It has antiproliferative activity in vitro against acute lymphoblastic leukemia (ALL) cells (IC50s = 0.5 and 1.2 μM for 697 and Jurkat cell lines, respectively) and inhibits Mer phosphorylation (IC50s = 141 and 193 nM in 697 and Jurkat cell lines, respectively). UNC569 activates Akt and ERK1/2 phosphorylation, induces apoptosis, and sensitizes ALL cells to etoposide (Item No. 12092) and methotrexate (Item No. 13960). In vivo, UNC569 (4 μM) decreases tumor burden by 47.8% relative to vehicle controls in human MYC transgenic zebrafish. UNC569 (10 mg/kg) delays leukemia onset, reduces CNS infiltration, and prolongs survival of mice implanted with patient-derived Mer-expressing ALL primary cells.{41373}
Brand:CaymanSKU:22966 - 25 mgAvailable on backorder
UNC569 is a potent inhibitor of the TAM family receptor tyrosine kinases Mer, Axl, and Tyro3 (IC50s = 2.9, 37, and 48 nM, respectively).{41372} It has antiproliferative activity in vitro against acute lymphoblastic leukemia (ALL) cells (IC50s = 0.5 and 1.2 μM for 697 and Jurkat cell lines, respectively) and inhibits Mer phosphorylation (IC50s = 141 and 193 nM in 697 and Jurkat cell lines, respectively). UNC569 activates Akt and ERK1/2 phosphorylation, induces apoptosis, and sensitizes ALL cells to etoposide (Item No. 12092) and methotrexate (Item No. 13960). In vivo, UNC569 (4 μM) decreases tumor burden by 47.8% relative to vehicle controls in human MYC transgenic zebrafish. UNC569 (10 mg/kg) delays leukemia onset, reduces CNS infiltration, and prolongs survival of mice implanted with patient-derived Mer-expressing ALL primary cells.{41373}
Brand:CaymanSKU:22966 - 5 mgAvailable on backorder
UNC669 is an inhibitor of the MBT domain of L3MBTL1 with an IC50 value of 6 µM.{19425} It is 5- and 10-fold selective for L3MBTL1 over the related proteins L3MBTL3 and L3MBTL4.
Brand:CaymanSKU:10875 - 10 mgAvailable on backorder
UNC669 is an inhibitor of the MBT domain of L3MBTL1 with an IC50 value of 6 µM.{19425} It is 5- and 10-fold selective for L3MBTL1 over the related proteins L3MBTL3 and L3MBTL4.
Brand:CaymanSKU:10875 - 25 mgAvailable on backorder
UNC669 is an inhibitor of the MBT domain of L3MBTL1 with an IC50 value of 6 µM.{19425} It is 5- and 10-fold selective for L3MBTL1 over the related proteins L3MBTL3 and L3MBTL4.
Brand:CaymanSKU:10875 - 5 mgAvailable on backorder
UNC669 is an inhibitor of the MBT domain of L3MBTL1 with an IC50 value of 6 µM.{19425} It is 5- and 10-fold selective for L3MBTL1 over the related proteins L3MBTL3 and L3MBTL4.
Brand:CaymanSKU:10875 - 50 mgAvailable on backorder
UNC926 is an antagonist of the MBT domain-containing methyl-lysine reader proteins L3MBTL1, L3MBTL3, and L3MBTL4.{48422} It inhibits methyl-lysine histone peptide substrate binding of L3MBTL1, L3MBTL3, and L3MBTL4 (IC50s =3.9, 3.2, and 15.6 μM, respectively) selectively over MBT domain-containing MBTD1 and SFMBT1 and chromo domain-containing CBX7 (IC50s = >30 μM).
Brand:CaymanSKU:27302 - 10 mgAvailable on backorder
UNC926 is an antagonist of the MBT domain-containing methyl-lysine reader proteins L3MBTL1, L3MBTL3, and L3MBTL4.{48422} It inhibits methyl-lysine histone peptide substrate binding of L3MBTL1, L3MBTL3, and L3MBTL4 (IC50s =3.9, 3.2, and 15.6 μM, respectively) selectively over MBT domain-containing MBTD1 and SFMBT1 and chromo domain-containing CBX7 (IC50s = >30 μM).
Brand:CaymanSKU:27302 - 25 mgAvailable on backorder
UNC926 is an antagonist of the MBT domain-containing methyl-lysine reader proteins L3MBTL1, L3MBTL3, and L3MBTL4.{48422} It inhibits methyl-lysine histone peptide substrate binding of L3MBTL1, L3MBTL3, and L3MBTL4 (IC50s =3.9, 3.2, and 15.6 μM, respectively) selectively over MBT domain-containing MBTD1 and SFMBT1 and chromo domain-containing CBX7 (IC50s = >30 μM).
Brand:CaymanSKU:27302 - 5 mgAvailable on backorder
UNC926 is an antagonist of the MBT domain-containing methyl-lysine reader proteins L3MBTL1, L3MBTL3, and L3MBTL4.{48422} It inhibits methyl-lysine histone peptide substrate binding of L3MBTL1, L3MBTL3, and L3MBTL4 (IC50s =3.9, 3.2, and 15.6 μM, respectively) selectively over MBT domain-containing MBTD1 and SFMBT1 and chromo domain-containing CBX7 (IC50s = >30 μM).
Brand:CaymanSKU:27302 - 50 mgAvailable on backorder
Undecanoic acid is a saturated fatty acid containing eleven carbons (C11:0). It is cytotoxic to certain filamentous fungi and is used to study fungal mechanisms of resistance.{31490,31491} Undecanoic acid is also used to acylate larger molecules.{31489}
Brand:CaymanSKU:19721 -Available on backorder
Undecanoic acid is a saturated fatty acid containing eleven carbons (C11:0). It is cytotoxic to certain filamentous fungi and is used to study fungal mechanisms of resistance.{31490,31491} Undecanoic acid is also used to acylate larger molecules.{31489}
Brand:CaymanSKU:19721 -Available on backorder
Undecanoic acid methyl ester is an ester form of undecanoic acid (Item No. 19721). It inhibits settling of the sap-sucking insect M. persicae by 33.8% in a settling choice assay when applied to C. annuum leaf disks at a concentration of 50 µg/cm2.{47384} It also inhibits oviposition in B. tabaci and induces mortality in the nematode M. javanica when used at a concentration of 0.5 µg/µl. Undecanoic acid methyl ester is a minor component of biodiesel formed by the transesterification of freeze-dried municipal secondary sewage sludge.{47385}
Brand:CaymanSKU:26720 - 100 mgAvailable on backorder
Unguinol is a depsidone originally isolated from A. unguis.{37787} It is an inhibitor of pyruvate phosphate dikinase (PPDK; IC50 = 42.3 µM).{37788} It inhibits the growth of plants utilizing C4, but not C3, carbon fixation. Unguinol also inhibits the growth of the bacteria S. aureus and V. harveyi (GI50s = 8.7 and 69.5 µM, respectively) and H460, MCF-7, and SF-268 cancer cells (GI50s = 28.2, 50.8, and 44.3 µM, respectively).
Brand:CaymanSKU:24207 - 1 mgAvailable on backorder
Unguinol is a depsidone originally isolated from A. unguis.{37787} It is an inhibitor of pyruvate phosphate dikinase (PPDK; IC50 = 42.3 µM).{37788} It inhibits the growth of plants utilizing C4, but not C3, carbon fixation. Unguinol also inhibits the growth of the bacteria S. aureus and V. harveyi (GI50s = 8.7 and 69.5 µM, respectively) and H460, MCF-7, and SF-268 cancer cells (GI50s = 28.2, 50.8, and 44.3 µM, respectively).
Brand:CaymanSKU:24207 - 5 mgAvailable on backorder
Unguisin A is a cyclic heptapeptide originally isolated from the marine fungus E. unguis whose structure is comprised of amino acids and GABA.{39416} It binds to phosphate, pyrophosphate, and chloride but has no effect on chloride transport in a liposome-based assay.{39415} It exhibited moderate antibacterial activity against S. aureus and V. parahaemolyticus in one assay but no activity against a variety of bacteria, including S. aureus, in another.{39416,39415}
Brand:CaymanSKU:23878 - 1 mgAvailable on backorder
Unguisin A is a cyclic heptapeptide originally isolated from the marine fungus E. unguis whose structure is comprised of amino acids and GABA.{39416} It binds to phosphate, pyrophosphate, and chloride but has no effect on chloride transport in a liposome-based assay.{39415} It exhibited moderate antibacterial activity against S. aureus and V. parahaemolyticus in one assay but no activity against a variety of bacteria, including S. aureus, in another.{39416,39415}
Brand:CaymanSKU:23878 - 5 mgAvailable on backorder
Unguisin B is a cyclic heptapeptide originally isolated from the marine fungus E. unguis whose structure is comprised of amino acids and GABA.{39416}
Brand:CaymanSKU:25115 - 2.5 mgAvailable on backorder
Unguisin B is a cyclic heptapeptide originally isolated from the marine fungus E. unguis whose structure is comprised of amino acids and GABA.{39416}
Brand:CaymanSKU:25115 - 500 µgAvailable on backorder
Abscisic acid (ABA; Item No. 10073) is a plant hormone with diverse roles in disease resistance, plant development, and response to stresses (water, salt, temperature, and pathogens). Uniconazole is a plant growth regulator that functions by inhibiting cytochrome P450 707As (Ki = 68 nM), a family of enzymes that catabolize ABA, and thus, suppress gibberellin and sterol biosynthesis.{29006}
Brand:CaymanSKU:-Available on backorder
Abscisic acid (ABA; Item No. 10073) is a plant hormone with diverse roles in disease resistance, plant development, and response to stresses (water, salt, temperature, and pathogens). Uniconazole is a plant growth regulator that functions by inhibiting cytochrome P450 707As (Ki = 68 nM), a family of enzymes that catabolize ABA, and thus, suppress gibberellin and sterol biosynthesis.{29006}
Brand:CaymanSKU:-Available on backorder
Abscisic acid (ABA; Item No. 10073) is a plant hormone with diverse roles in disease resistance, plant development, and response to stresses (water, salt, temperature, and pathogens). Uniconazole is a plant growth regulator that functions by inhibiting cytochrome P450 707As (Ki = 68 nM), a family of enzymes that catabolize ABA, and thus, suppress gibberellin and sterol biosynthesis.{29006}
Brand:CaymanSKU:-Available on backorder
Abscisic acid (ABA; Item No. 10073) is a plant hormone with diverse roles in disease resistance, plant development, and response to stresses (water, salt, temperature, and pathogens). Uniconazole is a plant growth regulator that functions by inhibiting cytochrome P450 707As (Ki = 68 nM), a family of enzymes that catabolize ABA, and thus, suppress gibberellin and sterol biosynthesis.{29006}
Brand:CaymanSKU:-Available on backorder
Unoprostone is an analog of PGF2α with a 13,14-dihydro-15-keto modification and a two-carbon extension of the aliphatic lower side chain. The isopropyl ester of unoprostone (Catalog No. 16681) (Rescula) has been approved for clinical use as an ocular hypotensive drug.
Brand:CaymanSKU:-Out of stock
Unoprostone is an analog of PGF2α with a 13,14-dihydro-15-keto modification and a two-carbon extension of the aliphatic lower side chain. The isopropyl ester of unoprostone (Catalog No. 16681) (Rescula) has been approved for clinical use as an ocular hypotensive drug.
Brand:CaymanSKU:-Out of stock
Unoprostone is an analog of PGF2α with a 13,14-dihydro-15-keto modification and a two-carbon extension of the aliphatic lower side chain. The isopropyl ester of unoprostone (Catalog No. 16681) (Rescula) has been approved for clinical use as an ocular hypotensive drug.
Brand:CaymanSKU:-Out of stock
Unoprostone is an analog of PGF2α with a 13,14-dihydro-15-keto modification and a two-carbon extension of the aliphatic lower side chain. The isopropyl ester of unoprostone (Catalog No. 16681) (Rescula) has been approved for clinical use as an ocular hypotensive drug.
Brand:CaymanSKU:-Out of stock
Unoprostone isopropyl ester (Rescula) is the clinically approved, prodrug form of unoprostone, which is a free acid analog of prostaglandin F2α (PGF2α). Both latanoprost and Rescula have been approved for the treatment of ocular hypertension. Both analogs of PGF2α are believed to act by increasing the rate of aqueous humor outflow through the uveoscleral pathway.{3586} Both drugs are believed to act as prodrugs, with endogenous esterases within the eye releasing the free acid active form of the drug. The typical does of Rescula (one drop of 0.12% solution) is nearly 100 times that of latanoprost.{8147} Rescula has very little activity on isolated DP or TP receptors, less than 0.0005% the activity of PGE2 on EP3 receptors, and about 3% of the activity of PGF2α on FP receptors.{8148}
Brand:CaymanSKU:-Out of stock
Unoprostone isopropyl ester (Rescula) is the clinically approved, prodrug form of unoprostone, which is a free acid analog of prostaglandin F2α (PGF2α). Both latanoprost and Rescula have been approved for the treatment of ocular hypertension. Both analogs of PGF2α are believed to act by increasing the rate of aqueous humor outflow through the uveoscleral pathway.{3586} Both drugs are believed to act as prodrugs, with endogenous esterases within the eye releasing the free acid active form of the drug. The typical does of Rescula (one drop of 0.12% solution) is nearly 100 times that of latanoprost.{8147} Rescula has very little activity on isolated DP or TP receptors, less than 0.0005% the activity of PGE2 on EP3 receptors, and about 3% of the activity of PGF2α on FP receptors.{8148}
Brand:CaymanSKU:-Out of stock
Unoprostone isopropyl ester (Rescula) is the clinically approved, prodrug form of unoprostone, which is a free acid analog of prostaglandin F2α (PGF2α). Both latanoprost and Rescula have been approved for the treatment of ocular hypertension. Both analogs of PGF2α are believed to act by increasing the rate of aqueous humor outflow through the uveoscleral pathway.{3586} Both drugs are believed to act as prodrugs, with endogenous esterases within the eye releasing the free acid active form of the drug. The typical does of Rescula (one drop of 0.12% solution) is nearly 100 times that of latanoprost.{8147} Rescula has very little activity on isolated DP or TP receptors, less than 0.0005% the activity of PGE2 on EP3 receptors, and about 3% of the activity of PGF2α on FP receptors.{8148}
Brand:CaymanSKU:-Out of stock
Unoprostone isopropyl ester (Rescula) is the clinically approved, prodrug form of unoprostone, which is a free acid analog of prostaglandin F2α (PGF2α). Both latanoprost and Rescula have been approved for the treatment of ocular hypertension. Both analogs of PGF2α are believed to act by increasing the rate of aqueous humor outflow through the uveoscleral pathway.{3586} Both drugs are believed to act as prodrugs, with endogenous esterases within the eye releasing the free acid active form of the drug. The typical does of Rescula (one drop of 0.12% solution) is nearly 100 times that of latanoprost.{8147} Rescula has very little activity on isolated DP or TP receptors, less than 0.0005% the activity of PGE2 on EP3 receptors, and about 3% of the activity of PGF2α on FP receptors.{8148}
Brand:CaymanSKU:-Out of stock
Upadacitinib is a JAK1 inhibitor (IC50 = 47 nM).{49501} It is selective for JAK1 over JAK3 and tyrosine kinase 2 (Tyk2; IC50s = 2,304 and 4,690 nM, respectively), as well as a panel of 83 additional kinases at 1 µM, but does inhibit JAK2, Rho-associated kinase I (ROCK-I), and ROCK-II (IC50s = 120, 920, and 430 nM, respectively). Upadacitinib decreases cytokine-induced STAT phosphorylation in a variety of human cells with IC50 values ranging from 1.6 to 649 nM. It reduces M. tuberculosis-induced paw swelling and bone erosion in a rat model of arthritis when administered at doses of 1, 3, and 10 mg/kg twice per day for 17 days. Formulations containing upadacitinib have been used in the treatment of rheumatoid arthritis.
Brand:CaymanSKU:29706 - 1 mgAvailable on backorder
Upadacitinib is a JAK1 inhibitor (IC50 = 47 nM).{49501} It is selective for JAK1 over JAK3 and tyrosine kinase 2 (Tyk2; IC50s = 2,304 and 4,690 nM, respectively), as well as a panel of 83 additional kinases at 1 µM, but does inhibit JAK2, Rho-associated kinase I (ROCK-I), and ROCK-II (IC50s = 120, 920, and 430 nM, respectively). Upadacitinib decreases cytokine-induced STAT phosphorylation in a variety of human cells with IC50 values ranging from 1.6 to 649 nM. It reduces M. tuberculosis-induced paw swelling and bone erosion in a rat model of arthritis when administered at doses of 1, 3, and 10 mg/kg twice per day for 17 days. Formulations containing upadacitinib have been used in the treatment of rheumatoid arthritis.
Brand:CaymanSKU:29706 - 10 mgAvailable on backorder
Upadacitinib is a JAK1 inhibitor (IC50 = 47 nM).{49501} It is selective for JAK1 over JAK3 and tyrosine kinase 2 (Tyk2; IC50s = 2,304 and 4,690 nM, respectively), as well as a panel of 83 additional kinases at 1 µM, but does inhibit JAK2, Rho-associated kinase I (ROCK-I), and ROCK-II (IC50s = 120, 920, and 430 nM, respectively). Upadacitinib decreases cytokine-induced STAT phosphorylation in a variety of human cells with IC50 values ranging from 1.6 to 649 nM. It reduces M. tuberculosis-induced paw swelling and bone erosion in a rat model of arthritis when administered at doses of 1, 3, and 10 mg/kg twice per day for 17 days. Formulations containing upadacitinib have been used in the treatment of rheumatoid arthritis.
Brand:CaymanSKU:29706 - 25 mgAvailable on backorder
Upadacitinib is a JAK1 inhibitor (IC50 = 47 nM).{49501} It is selective for JAK1 over JAK3 and tyrosine kinase 2 (Tyk2; IC50s = 2,304 and 4,690 nM, respectively), as well as a panel of 83 additional kinases at 1 µM, but does inhibit JAK2, Rho-associated kinase I (ROCK-I), and ROCK-II (IC50s = 120, 920, and 430 nM, respectively). Upadacitinib decreases cytokine-induced STAT phosphorylation in a variety of human cells with IC50 values ranging from 1.6 to 649 nM. It reduces M. tuberculosis-induced paw swelling and bone erosion in a rat model of arthritis when administered at doses of 1, 3, and 10 mg/kg twice per day for 17 days. Formulations containing upadacitinib have been used in the treatment of rheumatoid arthritis.
Brand:CaymanSKU:29706 - 5 mgAvailable on backorder
The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis, particularly in response to reactive oxygen and nitrogen species. UPF-1069 is a PARP inhibitor that demonstrates a modest preference for PARP2 over PARP1 (IC50s = 0.3 and 8 µM, respectively).{31080} In rat models of post-ischemic brain damage, it has been shown to increase cell death in hippocampal slice cultures in a model characterized by loss of neurons through a caspase-dependent, apoptosis-like process but to be protective of cortical neurons in a model characterized by a necrosis-like process.{31079}
Brand:CaymanSKU:-Available on backorder
The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis, particularly in response to reactive oxygen and nitrogen species. UPF-1069 is a PARP inhibitor that demonstrates a modest preference for PARP2 over PARP1 (IC50s = 0.3 and 8 µM, respectively).{31080} In rat models of post-ischemic brain damage, it has been shown to increase cell death in hippocampal slice cultures in a model characterized by loss of neurons through a caspase-dependent, apoptosis-like process but to be protective of cortical neurons in a model characterized by a necrosis-like process.{31079}
Brand:CaymanSKU:-Available on backorder
The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis, particularly in response to reactive oxygen and nitrogen species. UPF-1069 is a PARP inhibitor that demonstrates a modest preference for PARP2 over PARP1 (IC50s = 0.3 and 8 µM, respectively).{31080} In rat models of post-ischemic brain damage, it has been shown to increase cell death in hippocampal slice cultures in a model characterized by loss of neurons through a caspase-dependent, apoptosis-like process but to be protective of cortical neurons in a model characterized by a necrosis-like process.{31079}
Brand:CaymanSKU:-Available on backorder
The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis, particularly in response to reactive oxygen and nitrogen species. UPF-1069 is a PARP inhibitor that demonstrates a modest preference for PARP2 over PARP1 (IC50s = 0.3 and 8 µM, respectively).{31080} In rat models of post-ischemic brain damage, it has been shown to increase cell death in hippocampal slice cultures in a model characterized by loss of neurons through a caspase-dependent, apoptosis-like process but to be protective of cortical neurons in a model characterized by a necrosis-like process.{31079}
Brand:CaymanSKU:-Available on backorder
Uprosertib is a selective, orally bioavailable inhibitor of Akt (IC50s = 180, 328, and 38 nM for Akt1, Akt2, and Akt3, respectively).{32165} Uprosertib preferentially inhibits the proliferation of human cancer cell lines with Akt pathway activation via PI3K/PTEN mutation or loss.{30969} It can cause cell cycle arrest and consequent tumor growth inhibition in mice bearing either BT474 breast tumor or SK-OV-3 ovarian tumor xenografts.{30969}
Brand:CaymanSKU:19904 -Available on backorder
Uprosertib is a selective, orally bioavailable inhibitor of Akt (IC50s = 180, 328, and 38 nM for Akt1, Akt2, and Akt3, respectively).{32165} Uprosertib preferentially inhibits the proliferation of human cancer cell lines with Akt pathway activation via PI3K/PTEN mutation or loss.{30969} It can cause cell cycle arrest and consequent tumor growth inhibition in mice bearing either BT474 breast tumor or SK-OV-3 ovarian tumor xenografts.{30969}
Brand:CaymanSKU:19904 -Available on backorder
Uprosertib is a selective, orally bioavailable inhibitor of Akt (IC50s = 180, 328, and 38 nM for Akt1, Akt2, and Akt3, respectively).{32165} Uprosertib preferentially inhibits the proliferation of human cancer cell lines with Akt pathway activation via PI3K/PTEN mutation or loss.{30969} It can cause cell cycle arrest and consequent tumor growth inhibition in mice bearing either BT474 breast tumor or SK-OV-3 ovarian tumor xenografts.{30969}
Brand:CaymanSKU:19904 -Available on backorder
Uprosertib is a selective, orally bioavailable inhibitor of Akt (IC50s = 180, 328, and 38 nM for Akt1, Akt2, and Akt3, respectively).{32165} Uprosertib preferentially inhibits the proliferation of human cancer cell lines with Akt pathway activation via PI3K/PTEN mutation or loss.{30969} It can cause cell cycle arrest and consequent tumor growth inhibition in mice bearing either BT474 breast tumor or SK-OV-3 ovarian tumor xenografts.{30969}
Brand:CaymanSKU:19904 -Available on backorder
UR-144 (Item No. 11502) is a synthetic cannabinoid (CB) analog of JWH 018 (Item No. 10900) in which the naphthalene ring is substituted with a tetramethylcyclopropyl group. This substitution results in a compound which is a potent agonist for the peripheral CB2 receptor.{20487} UR-144 Degradant is a common impurity observed during GC-MS analysis of samples containing UR-144. The opened ring of the degradant is presumed to be produced during heating of UR-144. This structure gives rise to a prominent fragment ion that is 15 amu greater than the base peak of UR-144. This pattern is consistent with McLafferty rearrangement of the degradant which does not occur with the parent compound.{21911}
Brand:CaymanSKU:11928 - 1 mgAvailable on backorder
UR-144 (Item No. 11502) is a synthetic cannabinoid (CB) analog of JWH 018 (Item No. 10900) in which the naphthalene ring is substituted with a tetramethylcyclopropyl group. This substitution results in a compound which is a potent agonist for the peripheral CB2 receptor.{20487} UR-144 Degradant is a common impurity observed during GC-MS analysis of samples containing UR-144. The opened ring of the degradant is presumed to be produced during heating of UR-144. This structure gives rise to a prominent fragment ion that is 15 amu greater than the base peak of UR-144. This pattern is consistent with McLafferty rearrangement of the degradant which does not occur with the parent compound.{21911}
Brand:CaymanSKU:11928 - 10 mgAvailable on backorder
UR-144 (Item No. 11502) is a synthetic cannabinoid (CB) analog of JWH 018 (Item No. 10900) in which the naphthalene ring is substituted with a tetramethylcyclopropyl group. This substitution results in a compound which is a potent agonist for the peripheral CB2 receptor.{20487} UR-144 Degradant is a common impurity observed during GC-MS analysis of samples containing UR-144. The opened ring of the degradant is presumed to be produced during heating of UR-144. This structure gives rise to a prominent fragment ion that is 15 amu greater than the base peak of UR-144. This pattern is consistent with McLafferty rearrangement of the degradant which does not occur with the parent compound.{21911}
Brand:CaymanSKU:11928 - 5 mgAvailable on backorder
UR-144 (Item No. 11502) is a potent synthetic cannabinoid (CB) that preferentially binds the peripheral CB2 receptor (Ki = 1.8 nM) over the central CB1 receptor (Ki = 150 nM).{20487} UR-144 Degradant N-pentanoic acid metabolite is a potential phase I metabolite of a degradation product observed during GC-MS analysis of samples containing UR-144.{19353,20170,22979} The biological activities of this compound have not been characterized. This product is intended for forensic and research applications.
Brand:CaymanSKU:9001453 - 1 mgAvailable on backorder
UR-144 (Item No. 11502) is a potent synthetic cannabinoid (CB) that preferentially binds the peripheral CB2 receptor (Ki = 1.8 nM) over the central CB1 receptor (Ki = 150 nM).{20487} UR-144 Degradant N-pentanoic acid metabolite is a potential phase I metabolite of a degradation product observed during GC-MS analysis of samples containing UR-144.{19353,20170,22979} The biological activities of this compound have not been characterized. This product is intended for forensic and research applications.
Brand:CaymanSKU:9001453 - 10 mgAvailable on backorder
UR-144 (Item No. 11502) is a potent synthetic cannabinoid (CB) that preferentially binds the peripheral CB2 receptor (Ki = 1.8 nM) over the central CB1 receptor (Ki = 150 nM).{20487} UR-144 Degradant N-pentanoic acid metabolite is a potential phase I metabolite of a degradation product observed during GC-MS analysis of samples containing UR-144.{19353,20170,22979} The biological activities of this compound have not been characterized. This product is intended for forensic and research applications.
Brand:CaymanSKU:9001453 - 5 mgAvailable on backorder
UR-144 (Item No. 11502) is a potent synthetic cannabinoid (CB) which preferentially binds the peripheral CB2 receptor (Ki = 1.8 nM) over the central CB1 receptor (Ki = 150 nM).{20487} UR-144 N-(5-bromopentyl) analog differs from UR-144 by having a bromine atom on the terminal carbon of the alkyl group. While similar modifications have little effect on the receptor affinities of analogs of tetrahydrocannabinol, the activity of this compound has not been examined.{21386,18632} This product is intended for research and forensic applications.
Brand:CaymanSKU:12003 - 1 mgAvailable on backorder
UR-144 (Item No. 11502) is a potent synthetic cannabinoid (CB) which preferentially binds the peripheral CB2 receptor (Ki = 1.8 nM) over the central CB1 receptor (Ki = 150 nM).{20487} UR-144 N-(5-bromopentyl) analog differs from UR-144 by having a bromine atom on the terminal carbon of the alkyl group. While similar modifications have little effect on the receptor affinities of analogs of tetrahydrocannabinol, the activity of this compound has not been examined.{21386,18632} This product is intended for research and forensic applications.
Brand:CaymanSKU:12003 - 10 mgAvailable on backorder
UR-144 (Item No. 11502) is a potent synthetic cannabinoid (CB) which preferentially binds the peripheral CB2 receptor (Ki = 1.8 nM) over the central CB1 receptor (Ki = 150 nM).{20487} UR-144 N-(5-bromopentyl) analog differs from UR-144 by having a bromine atom on the terminal carbon of the alkyl group. While similar modifications have little effect on the receptor affinities of analogs of tetrahydrocannabinol, the activity of this compound has not been examined.{21386,18632} This product is intended for research and forensic applications.
Brand:CaymanSKU:12003 - 5 mgAvailable on backorder
UR-144 (Item No. 11502) is a potent synthetic cannabinoid (CB) which preferentially binds the peripheral CB2 receptor (Ki = 1.8 nM) over the central CB1 receptor (Ki = 150 nM).{20487} UR-144 N-(5-chloropentyl) analog differs from UR-144 by having a chlorine atom on the terminal carbon of the alkyl group. The biological activities of this compound have not been characterized. This product is intended for forensic and research applications.
Brand:CaymanSKU:11951 - 1 mgAvailable on backorder
UR-144 (Item No. 11502) is a potent synthetic cannabinoid (CB) which preferentially binds the peripheral CB2 receptor (Ki = 1.8 nM) over the central CB1 receptor (Ki = 150 nM).{20487} UR-144 N-(5-chloropentyl) analog differs from UR-144 by having a chlorine atom on the terminal carbon of the alkyl group. The biological activities of this compound have not been characterized. This product is intended for forensic and research applications.
Brand:CaymanSKU:11951 - 10 mgAvailable on backorder
UR-144 (Item No. 11502) is a potent synthetic cannabinoid (CB) which preferentially binds the peripheral CB2 receptor (Ki = 1.8 nM) over the central CB1 receptor (Ki = 150 nM).{20487} UR-144 N-(5-chloropentyl) analog differs from UR-144 by having a chlorine atom on the terminal carbon of the alkyl group. The biological activities of this compound have not been characterized. This product is intended for forensic and research applications.
Brand:CaymanSKU:11951 - 5 mgAvailable on backorder
UR-144 is a potent synthetic cannabinoid (CB) which preferentially binds the peripheral CB2 receptor (Ki = 1.8 nM) over the central CB1 receptor (K i = 150 nM).{20487} UR-144 N-(5-hydroxypentyl) metabolite is an expected phase I metabolite of UR-144, based on the metabolism of similar cannabimimetics.{19353,20170} This metabolite should be detectable in either serum or urine. The physiological and toxicological properties of this compound have not been tested. This product is intended for forensic and research applications.
Brand:CaymanSKU:11775 - 1 mgAvailable on backorder
UR-144 is a potent synthetic cannabinoid (CB) which preferentially binds the peripheral CB2 receptor (Ki = 1.8 nM) over the central CB1 receptor (K i = 150 nM).{20487} UR-144 N-(5-hydroxypentyl) metabolite is an expected phase I metabolite of UR-144, based on the metabolism of similar cannabimimetics.{19353,20170} This metabolite should be detectable in either serum or urine. The physiological and toxicological properties of this compound have not been tested. This product is intended for forensic and research applications.
Brand:CaymanSKU:11775 - 10 mgAvailable on backorder
UR-144 is a potent synthetic cannabinoid (CB) which preferentially binds the peripheral CB2 receptor (Ki = 1.8 nM) over the central CB1 receptor (K i = 150 nM).{20487} UR-144 N-(5-hydroxypentyl) metabolite is an expected phase I metabolite of UR-144, based on the metabolism of similar cannabimimetics.{19353,20170} This metabolite should be detectable in either serum or urine. The physiological and toxicological properties of this compound have not been tested. This product is intended for forensic and research applications.
Brand:CaymanSKU:11775 - 5 mgAvailable on backorder
UR-144 (Item No. 11502) is a potent synthetic cannabinoid (CB) which preferentially binds the peripheral CB2 receptor (Ki = 1.8 nM) over the central CB1 receptor (Ki = 150 nM).{20487} UR-144 N-(5-hydroxypentyl) β-D-glucuronide is an expected major urinary metabolite of UR-144, based on the metabolism of similar cannabimimetics.{19353,20170} The physiological and toxicological properties of this compound have not been tested. This product is intended for forensic and research applications.
Brand:CaymanSKU:11776 - 1 mgAvailable on backorder
UR-144 (Item No. 11502) is a potent synthetic cannabinoid (CB) which preferentially binds the peripheral CB2 receptor (Ki = 1.8 nM) over the central CB1 receptor (Ki = 150 nM).{20487} UR-144 N-(5-hydroxypentyl) β-D-glucuronide is an expected major urinary metabolite of UR-144, based on the metabolism of similar cannabimimetics.{19353,20170} The physiological and toxicological properties of this compound have not been tested. This product is intended for forensic and research applications.
Brand:CaymanSKU:11776 - 500 µgAvailable on backorder
UR-144 (Item No. 11502) is a potent synthetic cannabinoid (CB) which preferentially binds the peripheral CB2 receptor (Ki = 1.8 nM) over the central CB1 receptor (Ki = 150 nM).{20487} UR-144 N-heptyl analog differs from UR-144 by having two additional carbons in the alkyl group. The biological activities of this compound have not been characterized. This product is intended for forensic and research applications.
Brand:CaymanSKU:- UR-144 (Item No. 11502) is a potent synthetic cannabinoid (CB) which preferentially binds the peripheral CB2 receptor (Ki = 1.8 nM) over the central CB1 receptor (Ki = 150 nM).{20487} UR-144 N-heptyl analog differs from UR-144 by having two additional carbons in the alkyl group. The biological activities of this compound have not been characterized. This product is intended for forensic and research applications.
Brand:CaymanSKU:- UR-144 (Item No. 11502) is a potent synthetic cannabinoid (CB) which preferentially binds the peripheral CB2 receptor (Ki = 1.8 nM) over the central CB1 receptor (Ki = 150 nM).{20487} UR-144 N-heptyl analog differs from UR-144 by having two additional carbons in the alkyl group. The biological activities of this compound have not been characterized. This product is intended for forensic and research applications.
Brand:CaymanSKU:-
UR-144 (Item No. 11502) is a potent synthetic cannabinoid (CB) which preferentially binds the peripheral CB2 receptor (Ki = 1.8 nM) over the central CB1 receptor (Ki = 150 nM).{20487} UR-144 N-pentanoic acid metabolite is an expected phase I metabolite of UR-144, based on the metabolism of similar cannabimimetics.{19353,20170} This metabolite should be detectable in either serum or urine.{19353,20170} The physiological and toxicological properties of this compound have not been tested. This product is intended for forensic and research applications.
Brand:CaymanSKU:11773 - 1 mgAvailable on backorder