Cayman
Showing 4201–4350 of 45550 results
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Amphetamines are chemical compounds characterized by an α-methylphenethylamine base structure. D-amphetamine (Item No. 14204) is a stimulant that binds the norepinephrine and dopamine transporters (EC50s = 7.1 and 24.8 nM, respectively).{23316} 2-Amino-1-phenylbutane is an amphetamine characterized by having an ethyl group in the alpha position. It has emerged as a potential recreational drug.{24764,24766} This product is a mixture of the D and L isomers. The D isomer of this compound partially substitutes for D-amphetamine in an animal discrimination analysis, suggesting that it weakly mimicks the signaling and stimulant properties of D-amphetamine.{24765} This product is intended for forensic and research applications.
Brand:CaymanSKU:9001864 - 5 mgAvailable on backorder
2-Amino-3-methylimidazo[4,5-f]quinoline (IQ) is a food-derived carcinogen that is found in high temperature-cooked meats and tobacco smoke.{39298} In humans, IQ is metabolized by the cytochrome (CYP) P450 isoform CYP1A2 and conjugated by N-acetyltransferase or sulfotransferase to a metabolite that reacts with DNA to form adducts. It induces formation of single-base substitutions and exon deletions and increases cell death in vitro in a concentration-dependent manner. In vivo, IQ increases the incidence of squamous cell hyperplasias in the stomach of p53 knockout mice and increases hepatocellular lesions in female mice regardless of p53 status.{39299}
Brand:CaymanSKU:21853 -Out of stock
2-Amino-3-methylimidazo[4,5-f]quinoline (IQ) is a food-derived carcinogen that is found in high temperature-cooked meats and tobacco smoke.{39298} In humans, IQ is metabolized by the cytochrome (CYP) P450 isoform CYP1A2 and conjugated by N-acetyltransferase or sulfotransferase to a metabolite that reacts with DNA to form adducts. It induces formation of single-base substitutions and exon deletions and increases cell death in vitro in a concentration-dependent manner. In vivo, IQ increases the incidence of squamous cell hyperplasias in the stomach of p53 knockout mice and increases hepatocellular lesions in female mice regardless of p53 status.{39299}
Brand:CaymanSKU:21853 -Out of stock
2-Amino-3-methylimidazo[4,5-f]quinoline (IQ) is a food-derived carcinogen that is found in high temperature-cooked meats and tobacco smoke.{39298} In humans, IQ is metabolized by the cytochrome (CYP) P450 isoform CYP1A2 and conjugated by N-acetyltransferase or sulfotransferase to a metabolite that reacts with DNA to form adducts. It induces formation of single-base substitutions and exon deletions and increases cell death in vitro in a concentration-dependent manner. In vivo, IQ increases the incidence of squamous cell hyperplasias in the stomach of p53 knockout mice and increases hepatocellular lesions in female mice regardless of p53 status.{39299}
Brand:CaymanSKU:21853 -Out of stock
2-Amino-3,4-dimethyl-3H-imidazo[4,5-f]quinoline is a mutagenic heterocyclic amine that has been found in cooked foods.{49713,49714,49715} It is mutagenic to S. typhimurium in the Ames test.{49715} Dietary administration of 2-amino-3,4-dimethyl-3H-imidazo[4,5-f]quinoline (0.03%) induces tumor formation in the Zymbal gland, oral cavity, and colon in male and female rats, the skin of male rats, and the mammary gland in female rats.{49713}
Brand:CaymanSKU:31509 - 1 mgAvailable on backorder
2-Amino-3,4-dimethyl-3H-imidazo[4,5-f]quinoline is a mutagenic heterocyclic amine that has been found in cooked foods.{49713,49714,49715} It is mutagenic to S. typhimurium in the Ames test.{49715} Dietary administration of 2-amino-3,4-dimethyl-3H-imidazo[4,5-f]quinoline (0.03%) induces tumor formation in the Zymbal gland, oral cavity, and colon in male and female rats, the skin of male rats, and the mammary gland in female rats.{49713}
Brand:CaymanSKU:31509 - 10 mgAvailable on backorder
2-Amino-3,4-dimethyl-3H-imidazo[4,5-f]quinoline is a mutagenic heterocyclic amine that has been found in cooked foods.{49713,49714,49715} It is mutagenic to S. typhimurium in the Ames test.{49715} Dietary administration of 2-amino-3,4-dimethyl-3H-imidazo[4,5-f]quinoline (0.03%) induces tumor formation in the Zymbal gland, oral cavity, and colon in male and female rats, the skin of male rats, and the mammary gland in female rats.{49713}
Brand:CaymanSKU:31509 - 5 mgAvailable on backorder
Brand:CaymanSKU:11051 - 1 gAvailable on backorder
Brand:CaymanSKU:11051 - 100 mgAvailable on backorder
Brand:CaymanSKU:11051 - 250 mgAvailable on backorder
Brand:CaymanSKU:11051 - 500 mgAvailable on backorder
Brand:CaymanSKU:11058 - 1 gAvailable on backorder
Brand:CaymanSKU:11058 - 5 gAvailable on backorder
Brand:CaymanSKU:11058 - 500 mgAvailable on backorder
2-Amino-5-bromo-6-chloropyrazine is a heterocyclic building block.{53984,53985} It has been used in the synthesis of Akt inhibitors.
Brand:CaymanSKU:30917 - 1 gAvailable on backorder
2-Amino-5-bromo-6-chloropyrazine is a heterocyclic building block.{53984,53985} It has been used in the synthesis of Akt inhibitors.
Brand:CaymanSKU:30917 - 250 mgAvailable on backorder
2-Amino-5-bromo-6-chloropyrazine is a heterocyclic building block.{53984,53985} It has been used in the synthesis of Akt inhibitors.
Brand:CaymanSKU:30917 - 5 gAvailable on backorder
2-Amino-5-bromo-6-chloropyrazine is a heterocyclic building block.{53984,53985} It has been used in the synthesis of Akt inhibitors.
Brand:CaymanSKU:30917 - 500 mgAvailable on backorder
2-Amino-5-bromo-benzonitrile is a heterocyclic building block.{52532,24514} It has been used in the synthesis of copper-ligand coordination complexes and 4-amino-3-benzimidazol-2-ylhydroquinolin-2-one-based multi-targeted receptor tyrosine kinase (RTK) inhibitors with anticancer activity.
Brand:CaymanSKU:30454 - 1 gAvailable on backorder
2-Amino-5-bromo-benzonitrile is a heterocyclic building block.{52532,24514} It has been used in the synthesis of copper-ligand coordination complexes and 4-amino-3-benzimidazol-2-ylhydroquinolin-2-one-based multi-targeted receptor tyrosine kinase (RTK) inhibitors with anticancer activity.
Brand:CaymanSKU:30454 - 500 mgAvailable on backorder
2-Amino-5-fluorobenzoic acid is a toxic antimetabolite for the tryptophan pathway in yeast that can be used to counterselect for TRP1, a commonly used genetic marker in S. cerevisiae.{27254} Because this trp1 strain lacks the enzymes required for the conversion of anthranilic acid to tryptophan, it is resistant to 2-amino-5-fluorobenzoic acid feedback inhibition, enabling a growth-based, positive selection of the TRP1 marker. 2-Amino-5-fluorobenzoic acid is frequently used in genetic procedures that involve plasmid manipulations.{27254}
Brand:CaymanSKU:-Out of stock
2-Amino-5-fluorobenzoic acid is a toxic antimetabolite for the tryptophan pathway in yeast that can be used to counterselect for TRP1, a commonly used genetic marker in S. cerevisiae.{27254} Because this trp1 strain lacks the enzymes required for the conversion of anthranilic acid to tryptophan, it is resistant to 2-amino-5-fluorobenzoic acid feedback inhibition, enabling a growth-based, positive selection of the TRP1 marker. 2-Amino-5-fluorobenzoic acid is frequently used in genetic procedures that involve plasmid manipulations.{27254}
Brand:CaymanSKU:-Out of stock
2-Amino-5-fluorobenzoic acid is a toxic antimetabolite for the tryptophan pathway in yeast that can be used to counterselect for TRP1, a commonly used genetic marker in S. cerevisiae.{27254} Because this trp1 strain lacks the enzymes required for the conversion of anthranilic acid to tryptophan, it is resistant to 2-amino-5-fluorobenzoic acid feedback inhibition, enabling a growth-based, positive selection of the TRP1 marker. 2-Amino-5-fluorobenzoic acid is frequently used in genetic procedures that involve plasmid manipulations.{27254}
Brand:CaymanSKU:-Out of stock
Brand:CaymanSKU:13061 - 1 gAvailable on backorder
Brand:CaymanSKU:13061 - 100 mgAvailable on backorder
Brand:CaymanSKU:13061 - 250 mgAvailable on backorder
Brand:CaymanSKU:13061 - 500 mgAvailable on backorder
2-Amino-6-chloropurine is a precursor in the synthesis of nucleoside analogs with antiviral activity against Epstein-Barr virus (EBV) and human herpes virus 6 (HHV-6).{53720}
Brand:CaymanSKU:30400 - 1 gAvailable on backorder
2-Amino-6-chloropurine is a precursor in the synthesis of nucleoside analogs with antiviral activity against Epstein-Barr virus (EBV) and human herpes virus 6 (HHV-6).{53720}
Brand:CaymanSKU:30400 - 10 gAvailable on backorder
2-Amino-6-chloropurine is a precursor in the synthesis of nucleoside analogs with antiviral activity against Epstein-Barr virus (EBV) and human herpes virus 6 (HHV-6).{53720}
Brand:CaymanSKU:30400 - 5 gAvailable on backorder
Receptor-induced calcium signalling relies on inositol-1,4,5-triphosphate receptors.{11002} These receptors can be blocked by the cell-permeable antagonist 2-aminoethyl diphenylborinate. In fura-loaded DDT1MF-2 cells, 75 µM 2-aminoethyl diphenylborinate completely ablates the thapsigargin-induced calcium transients that are also antagonized by xestospongin C.{9842}
Brand:CaymanSKU:64970 - 1 gAvailable on backorder
Receptor-induced calcium signalling relies on inositol-1,4,5-triphosphate receptors.{11002} These receptors can be blocked by the cell-permeable antagonist 2-aminoethyl diphenylborinate. In fura-loaded DDT1MF-2 cells, 75 µM 2-aminoethyl diphenylborinate completely ablates the thapsigargin-induced calcium transients that are also antagonized by xestospongin C.{9842}
Brand:CaymanSKU:64970 - 5 gAvailable on backorder
2-Aminomethylpyrimidine (hydrochloride) is a synthetic intermediate useful for pharmaceutical synthesis.
Brand:CaymanSKU:10007106 - 1 gAvailable on backorder
2-Aminomethylpyrimidine (hydrochloride) is a synthetic intermediate useful for pharmaceutical synthesis.
Brand:CaymanSKU:10007106 - 100 mgAvailable on backorder
2-Aminomethylpyrimidine (hydrochloride) is a synthetic intermediate useful for pharmaceutical synthesis.
Brand:CaymanSKU:10007106 - 50 mgAvailable on backorder
2-Aminomethylpyrimidine (hydrochloride) is a synthetic intermediate useful for pharmaceutical synthesis.
Brand:CaymanSKU:10007106 - 500 mgAvailable on backorder
2-Aminopurine is a fluorescent analog of guanosine and adenosine that is used as a site-specific probe of nucleic acid structure and dynamics.{30070} It base pairs with cytosine in a wobble configuration or with thymine in a Watson–Crick geometry.{30070} In addition to its usefulness in studies of base stacking interactions, 2-aminopurine has been used as a probe for DNA base flipping by methyl transferases.{30069} 2-Aminopurine exhibits an excitation/emission of 320/381 nm, respectively, when adjusted to reduce interference with DNA base absorption as well as tryptophan fluorescence.{30069} 2-Aminopurine inhibits the double-stranded RNA-dependent protein kinase, protein kinase R, whose activity mediates antiviral defense and participates in toll-like receptor signaling.{30068}
Brand:CaymanSKU:-Available on backorder
2-Aminopurine is a fluorescent analog of guanosine and adenosine that is used as a site-specific probe of nucleic acid structure and dynamics.{30070} It base pairs with cytosine in a wobble configuration or with thymine in a Watson–Crick geometry.{30070} In addition to its usefulness in studies of base stacking interactions, 2-aminopurine has been used as a probe for DNA base flipping by methyl transferases.{30069} 2-Aminopurine exhibits an excitation/emission of 320/381 nm, respectively, when adjusted to reduce interference with DNA base absorption as well as tryptophan fluorescence.{30069} 2-Aminopurine inhibits the double-stranded RNA-dependent protein kinase, protein kinase R, whose activity mediates antiviral defense and participates in toll-like receptor signaling.{30068}
Brand:CaymanSKU:-Available on backorder
2-Aminopurine is a fluorescent analog of guanosine and adenosine that is used as a site-specific probe of nucleic acid structure and dynamics.{30070} It base pairs with cytosine in a wobble configuration or with thymine in a Watson–Crick geometry.{30070} In addition to its usefulness in studies of base stacking interactions, 2-aminopurine has been used as a probe for DNA base flipping by methyl transferases.{30069} 2-Aminopurine exhibits an excitation/emission of 320/381 nm, respectively, when adjusted to reduce interference with DNA base absorption as well as tryptophan fluorescence.{30069} 2-Aminopurine inhibits the double-stranded RNA-dependent protein kinase, protein kinase R, whose activity mediates antiviral defense and participates in toll-like receptor signaling.{30068}
Brand:CaymanSKU:-Available on backorder
2-Aminopurine is a fluorescent analog of guanosine and adenosine that is used as a site-specific probe of nucleic acid structure and dynamics.{30070} It base pairs with cytosine in a wobble configuration or with thymine in a Watson–Crick geometry.{30070} In addition to its usefulness in studies of base stacking interactions, 2-aminopurine has been used as a probe for DNA base flipping by methyl transferases.{30069} 2-Aminopurine exhibits an excitation/emission of 320/381 nm, respectively, when adjusted to reduce interference with DNA base absorption as well as tryptophan fluorescence.{30069} 2-Aminopurine inhibits the double-stranded RNA-dependent protein kinase, protein kinase R, whose activity mediates antiviral defense and participates in toll-like receptor signaling.{30068}
Brand:CaymanSKU:-Available on backorder
Brand:CaymanSKU:10007093 - 10 gAvailable on backorder
Brand:CaymanSKU:10007093 - 25 gAvailable on backorder
Brand:CaymanSKU:10007093 - 5 gAvailable on backorder
Brand:CaymanSKU:10007093 - 50 gAvailable on backorder
2-Arachidonoyl glycerol (2-AG) is an endogenous agonist of the cannabinoid (CB) receptors CB1 and CB2 (Kis = 25.3-472 and 145-1,400 nM, respectively).{7183,7182,7912} Unlike arachidonoyl ethanolamide (AEA; Item No. 90050), 2-AG is present at relatively high levels in the central nervous system and is the most abundant molecular species of monoacylglycerol (MAG) found in rat brain.{7183,6819} Formation of 2-AG is calcium-dependent and is mediated by the activities of phospholipase C (PLC) and diacylglycerol (DAG) lipase.{7183} 2-AG acts as a full agonist at the CB1 receptor. At a concentration of 0.3 nM, 2-AG induces a rapid, transient increase in intracellular free calcium in NG108-15 neuroblastoma X glioma cells through a CB1 receptor-dependent mechanism.{7182} 2-AG is metabolized in vitro by MAG lipase and fatty acid amide hydrolase (FAAH), with MAG lipase likely being the principle metabolizing enzyme in vivo.{11364}
Brand:CaymanSKU:62160 - 1 mgAvailable on backorder
2-Arachidonoyl glycerol (2-AG) is an endogenous agonist of the cannabinoid (CB) receptors CB1 and CB2 (Kis = 25.3-472 and 145-1,400 nM, respectively).{7183,7182,7912} Unlike arachidonoyl ethanolamide (AEA; Item No. 90050), 2-AG is present at relatively high levels in the central nervous system and is the most abundant molecular species of monoacylglycerol (MAG) found in rat brain.{7183,6819} Formation of 2-AG is calcium-dependent and is mediated by the activities of phospholipase C (PLC) and diacylglycerol (DAG) lipase.{7183} 2-AG acts as a full agonist at the CB1 receptor. At a concentration of 0.3 nM, 2-AG induces a rapid, transient increase in intracellular free calcium in NG108-15 neuroblastoma X glioma cells through a CB1 receptor-dependent mechanism.{7182} 2-AG is metabolized in vitro by MAG lipase and fatty acid amide hydrolase (FAAH), with MAG lipase likely being the principle metabolizing enzyme in vivo.{11364}
Brand:CaymanSKU:62160 - 10 mgAvailable on backorder
2-Arachidonoyl glycerol (2-AG) is an endogenous agonist of the cannabinoid (CB) receptors CB1 and CB2 (Kis = 25.3-472 and 145-1,400 nM, respectively).{7183,7182,7912} Unlike arachidonoyl ethanolamide (AEA; Item No. 90050), 2-AG is present at relatively high levels in the central nervous system and is the most abundant molecular species of monoacylglycerol (MAG) found in rat brain.{7183,6819} Formation of 2-AG is calcium-dependent and is mediated by the activities of phospholipase C (PLC) and diacylglycerol (DAG) lipase.{7183} 2-AG acts as a full agonist at the CB1 receptor. At a concentration of 0.3 nM, 2-AG induces a rapid, transient increase in intracellular free calcium in NG108-15 neuroblastoma X glioma cells through a CB1 receptor-dependent mechanism.{7182} 2-AG is metabolized in vitro by MAG lipase and fatty acid amide hydrolase (FAAH), with MAG lipase likely being the principle metabolizing enzyme in vivo.{11364}
Brand:CaymanSKU:62160 - 25 mgAvailable on backorder
2-Arachidonoyl glycerol (2-AG) is an endogenous agonist of the cannabinoid (CB) receptors CB1 and CB2 (Kis = 25.3-472 and 145-1,400 nM, respectively).{7183,7182,7912} Unlike arachidonoyl ethanolamide (AEA; Item No. 90050), 2-AG is present at relatively high levels in the central nervous system and is the most abundant molecular species of monoacylglycerol (MAG) found in rat brain.{7183,6819} Formation of 2-AG is calcium-dependent and is mediated by the activities of phospholipase C (PLC) and diacylglycerol (DAG) lipase.{7183} 2-AG acts as a full agonist at the CB1 receptor. At a concentration of 0.3 nM, 2-AG induces a rapid, transient increase in intracellular free calcium in NG108-15 neuroblastoma X glioma cells through a CB1 receptor-dependent mechanism.{7182} 2-AG is metabolized in vitro by MAG lipase and fatty acid amide hydrolase (FAAH), with MAG lipase likely being the principle metabolizing enzyme in vivo.{11364}
Brand:CaymanSKU:62160 - 5 mgAvailable on backorder
2-Arachidonoyl glycerol-d8 (2-AG-d8) is intended for use as an internal standard for the quantification of 2-AG (Item No. 62160) by GC- or LC-MS. 2-AG is an endogenous agonist of the CB1 receptor.{7183,7182} Unlike anandamide, 2-AG is present at relatively high levels in the central nervous system; it is the most abundant molecular species of monoacylglycerol found in rat brain.{7183,6819} Formation of 2-AG is calcium-dependent and is mediated by the activities of phospholipase C and diacylglycerol lipase.{7183} 2-AG acts as a full agonist at the CB1 receptor. At a concentration of 0.3 nM, 2-AG induces a rapid, transient increase in intracellular free calcium in NG108-15 neuroblastoma X glioma cells through a receptor-dependent mechanism.{5306}
Brand:CaymanSKU:362160 - 100 µgAvailable on backorder
2-Arachidonoyl glycerol-d8 (2-AG-d8) is intended for use as an internal standard for the quantification of 2-AG (Item No. 62160) by GC- or LC-MS. 2-AG is an endogenous agonist of the CB1 receptor.{7183,7182} Unlike anandamide, 2-AG is present at relatively high levels in the central nervous system; it is the most abundant molecular species of monoacylglycerol found in rat brain.{7183,6819} Formation of 2-AG is calcium-dependent and is mediated by the activities of phospholipase C and diacylglycerol lipase.{7183} 2-AG acts as a full agonist at the CB1 receptor. At a concentration of 0.3 nM, 2-AG induces a rapid, transient increase in intracellular free calcium in NG108-15 neuroblastoma X glioma cells through a receptor-dependent mechanism.{5306}
Brand:CaymanSKU:362160 - 25 µgAvailable on backorder
2-Arachidonoyl glycerol-d8 (2-AG-d8) is intended for use as an internal standard for the quantification of 2-AG (Item No. 62160) by GC- or LC-MS. 2-AG is an endogenous agonist of the CB1 receptor.{7183,7182} Unlike anandamide, 2-AG is present at relatively high levels in the central nervous system; it is the most abundant molecular species of monoacylglycerol found in rat brain.{7183,6819} Formation of 2-AG is calcium-dependent and is mediated by the activities of phospholipase C and diacylglycerol lipase.{7183} 2-AG acts as a full agonist at the CB1 receptor. At a concentration of 0.3 nM, 2-AG induces a rapid, transient increase in intracellular free calcium in NG108-15 neuroblastoma X glioma cells through a receptor-dependent mechanism.{5306}
Brand:CaymanSKU:362160 - 50 µgAvailable on backorder
2-Arachidonoyl glycerol-d8 (2-AG-d8) is intended for use as an internal standard for the quantification of 2-AG (Item No. 62160) by GC- or LC-MS. 2-AG is an endogenous agonist of the CB1 receptor.{7183,7182} Unlike anandamide, 2-AG is present at relatively high levels in the central nervous system; it is the most abundant molecular species of monoacylglycerol found in rat brain.{7183,6819} Formation of 2-AG is calcium-dependent and is mediated by the activities of phospholipase C and diacylglycerol lipase.{7183} 2-AG acts as a full agonist at the CB1 receptor. At a concentration of 0.3 nM, 2-AG induces a rapid, transient increase in intracellular free calcium in NG108-15 neuroblastoma X glioma cells through a receptor-dependent mechanism.{5306}
Brand:CaymanSKU:362160 - 500 µgAvailable on backorder
2-Arachidonyl glycerol ether (2-AG ether) selectively binds to cannabinoid (CB) receptor 1 (Kis = 21.2 and >3,000 nM for CB1 and CB2, respectively, in a radioligand binding assay).{8945} It is a potent and selective agonist of CB1 and GPR55 with EC50 values of 10, 37, and >30,000 nM for CB1, GPR55, and CB2, respectively.{17583} 2-AG ether displays the typical tetrad of CB activities in mice.{8945} It is more chemically stable than 2-AG (Item No. 62160), with an endogenous half-life of hours rather than minutes.{10462} However, it is at least 10-fold less potent than 2-AG in eliciting typical CB1-mediated responses.{7182} 2-AG ether elicits modest reductions in intraocular pressure in rabbits when administered at doses exceeding 50 µg per eye.{10462} It increases aqueous humor outflow via the CB1 receptor in the trabecular meshwork.{14129} Administration of 2-AG ether to the nucleus accumbens (0.0625-1 μg) increases dietary intake and enhances fat consumption in rats given access to both high-carbohydrate and high-fat diets.{38343}
Brand:CaymanSKU:62165 - 1 mgAvailable on backorder
2-Arachidonyl glycerol ether (2-AG ether) selectively binds to cannabinoid (CB) receptor 1 (Kis = 21.2 and >3,000 nM for CB1 and CB2, respectively, in a radioligand binding assay).{8945} It is a potent and selective agonist of CB1 and GPR55 with EC50 values of 10, 37, and >30,000 nM for CB1, GPR55, and CB2, respectively.{17583} 2-AG ether displays the typical tetrad of CB activities in mice.{8945} It is more chemically stable than 2-AG (Item No. 62160), with an endogenous half-life of hours rather than minutes.{10462} However, it is at least 10-fold less potent than 2-AG in eliciting typical CB1-mediated responses.{7182} 2-AG ether elicits modest reductions in intraocular pressure in rabbits when administered at doses exceeding 50 µg per eye.{10462} It increases aqueous humor outflow via the CB1 receptor in the trabecular meshwork.{14129} Administration of 2-AG ether to the nucleus accumbens (0.0625-1 μg) increases dietary intake and enhances fat consumption in rats given access to both high-carbohydrate and high-fat diets.{38343}
Brand:CaymanSKU:62165 - 10 mgAvailable on backorder
2-Arachidonyl glycerol ether (2-AG ether) selectively binds to cannabinoid (CB) receptor 1 (Kis = 21.2 and >3,000 nM for CB1 and CB2, respectively, in a radioligand binding assay).{8945} It is a potent and selective agonist of CB1 and GPR55 with EC50 values of 10, 37, and >30,000 nM for CB1, GPR55, and CB2, respectively.{17583} 2-AG ether displays the typical tetrad of CB activities in mice.{8945} It is more chemically stable than 2-AG (Item No. 62160), with an endogenous half-life of hours rather than minutes.{10462} However, it is at least 10-fold less potent than 2-AG in eliciting typical CB1-mediated responses.{7182} 2-AG ether elicits modest reductions in intraocular pressure in rabbits when administered at doses exceeding 50 µg per eye.{10462} It increases aqueous humor outflow via the CB1 receptor in the trabecular meshwork.{14129} Administration of 2-AG ether to the nucleus accumbens (0.0625-1 μg) increases dietary intake and enhances fat consumption in rats given access to both high-carbohydrate and high-fat diets.{38343}
Brand:CaymanSKU:62165 - 25 mgAvailable on backorder
2-Arachidonyl glycerol ether (2-AG ether) selectively binds to cannabinoid (CB) receptor 1 (Kis = 21.2 and >3,000 nM for CB1 and CB2, respectively, in a radioligand binding assay).{8945} It is a potent and selective agonist of CB1 and GPR55 with EC50 values of 10, 37, and >30,000 nM for CB1, GPR55, and CB2, respectively.{17583} 2-AG ether displays the typical tetrad of CB activities in mice.{8945} It is more chemically stable than 2-AG (Item No. 62160), with an endogenous half-life of hours rather than minutes.{10462} However, it is at least 10-fold less potent than 2-AG in eliciting typical CB1-mediated responses.{7182} 2-AG ether elicits modest reductions in intraocular pressure in rabbits when administered at doses exceeding 50 µg per eye.{10462} It increases aqueous humor outflow via the CB1 receptor in the trabecular meshwork.{14129} Administration of 2-AG ether to the nucleus accumbens (0.0625-1 μg) increases dietary intake and enhances fat consumption in rats given access to both high-carbohydrate and high-fat diets.{38343}
Brand:CaymanSKU:62165 - 5 mgAvailable on backorder
2-bromo Deschloroketamine (Item No. 30367) is an analytical reference standard categorized as an arylcyclohexylamine.{49018} This product is intended for research and forensic applications.
Brand:CaymanSKU:30367 - 1 mgAvailable on backorder
2-bromo Deschloroketamine (Item No. 30367) is an analytical reference standard categorized as an arylcyclohexylamine.{49018} This product is intended for research and forensic applications.
Brand:CaymanSKU:30367 - 5 mgAvailable on backorder
2-bromo-4,5-Dimethoxyphenethylamine (hydrochloride) (Item No. 29386) is an analytical reference standard categorized as a phenethylamine. This product is intended for research and forensic applications.
Brand:CaymanSKU:29386 - 1 mgAvailable on backorder
2-bromo-4,5-Dimethoxyphenethylamine (hydrochloride) (Item No. 29386) is an analytical reference standard categorized as a phenethylamine. This product is intended for research and forensic applications.
Brand:CaymanSKU:29386 - 5 mgAvailable on backorder
4-Bromoamphetamine (4-BA) (Item No. 9001850) is a para-substituted amphetamine that acts as a monoamine releasing agent.{25537,25538} It is highly neurotoxic, producing long-term depletion of serotonin.{25537,25538} 2-BA is a structural isomer of 4-BA, having the bromine at the two rather than the four position. This product is intended only for forensic and research purposes.
Brand:CaymanSKU:9001848 - 1 mgAvailable on backorder
4-Bromoamphetamine (4-BA) (Item No. 9001850) is a para-substituted amphetamine that acts as a monoamine releasing agent.{25537,25538} It is highly neurotoxic, producing long-term depletion of serotonin.{25537,25538} 2-BA is a structural isomer of 4-BA, having the bromine at the two rather than the four position. This product is intended only for forensic and research purposes.
Brand:CaymanSKU:9001848 - 10 mgAvailable on backorder
4-Bromoamphetamine (4-BA) (Item No. 9001850) is a para-substituted amphetamine that acts as a monoamine releasing agent.{25537,25538} It is highly neurotoxic, producing long-term depletion of serotonin.{25537,25538} 2-BA is a structural isomer of 4-BA, having the bromine at the two rather than the four position. This product is intended only for forensic and research purposes.
Brand:CaymanSKU:9001848 - 5 mgAvailable on backorder
2-BZP (Item No. 24419) is an analytical reference standard categorized as a piperazine. This product is intended for research and forensic applications.
Brand:CaymanSKU:24419 - 1 mgAvailable on backorder
2-BZP (Item No. 24419) is an analytical reference standard categorized as a piperazine. This product is intended for research and forensic applications.
Brand:CaymanSKU:24419 - 5 mgAvailable on backorder
Brand:CaymanSKU:10007123 - 1 gAvailable on backorder
Brand:CaymanSKU:10007123 - 5 gAvailable on backorder
Brand:CaymanSKU:10007123 - 500 mgAvailable on backorder
2-chloro Palmitic acid is a monochlorinated form of palmitic acid (Item No. 10006627). It is produced in a myeloperoxidase (MPO) and time-dependent manner in neutrophils stimulated by phorbol 12-myristate 13-acetate (PMA; Item No. 10008014). 2-chloro Palmitic acid (10 μM) induces neutrophil extracellular trap (NET) formation (NETosis) in human neutrophils, increasing DNA release from neutrophils, colocalization of MPO with extracellular DNA (ecDNA), and trapping of E. coli.{43363} It increases COX-2 protein levels in human coronary artery endothelial cells (HCAECs) when used at a concentration of 50 μM and increases production of P-selectin, von Willebrand factor, and angiopoietin-2 in HCAECs, as well as neutrophil and platelet adherence, when used at a concentration of 10 μM.{43481,43482} 2-chloro Palmitic acid (10-50 μM) also induces apoptosis in THP-1 cells and primary human monocytes and increases caspase-3 activity in THP-1 cells.{43483}
Brand:CaymanSKU:26107 - 1 mgAvailable on backorder
2-chloro Palmitic acid is a monochlorinated form of palmitic acid (Item No. 10006627). It is produced in a myeloperoxidase (MPO) and time-dependent manner in neutrophils stimulated by phorbol 12-myristate 13-acetate (PMA; Item No. 10008014). 2-chloro Palmitic acid (10 μM) induces neutrophil extracellular trap (NET) formation (NETosis) in human neutrophils, increasing DNA release from neutrophils, colocalization of MPO with extracellular DNA (ecDNA), and trapping of E. coli.{43363} It increases COX-2 protein levels in human coronary artery endothelial cells (HCAECs) when used at a concentration of 50 μM and increases production of P-selectin, von Willebrand factor, and angiopoietin-2 in HCAECs, as well as neutrophil and platelet adherence, when used at a concentration of 10 μM.{43481,43482} 2-chloro Palmitic acid (10-50 μM) also induces apoptosis in THP-1 cells and primary human monocytes and increases caspase-3 activity in THP-1 cells.{43483}
Brand:CaymanSKU:26107 - 10 mgAvailable on backorder
2-chloro Palmitic acid is a monochlorinated form of palmitic acid (Item No. 10006627). It is produced in a myeloperoxidase (MPO) and time-dependent manner in neutrophils stimulated by phorbol 12-myristate 13-acetate (PMA; Item No. 10008014). 2-chloro Palmitic acid (10 μM) induces neutrophil extracellular trap (NET) formation (NETosis) in human neutrophils, increasing DNA release from neutrophils, colocalization of MPO with extracellular DNA (ecDNA), and trapping of E. coli.{43363} It increases COX-2 protein levels in human coronary artery endothelial cells (HCAECs) when used at a concentration of 50 μM and increases production of P-selectin, von Willebrand factor, and angiopoietin-2 in HCAECs, as well as neutrophil and platelet adherence, when used at a concentration of 10 μM.{43481,43482} 2-chloro Palmitic acid (10-50 μM) also induces apoptosis in THP-1 cells and primary human monocytes and increases caspase-3 activity in THP-1 cells.{43483}
Brand:CaymanSKU:26107 - 25 mgAvailable on backorder
2-chloro Palmitic acid is a monochlorinated form of palmitic acid (Item No. 10006627). It is produced in a myeloperoxidase (MPO) and time-dependent manner in neutrophils stimulated by phorbol 12-myristate 13-acetate (PMA; Item No. 10008014). 2-chloro Palmitic acid (10 μM) induces neutrophil extracellular trap (NET) formation (NETosis) in human neutrophils, increasing DNA release from neutrophils, colocalization of MPO with extracellular DNA (ecDNA), and trapping of E. coli.{43363} It increases COX-2 protein levels in human coronary artery endothelial cells (HCAECs) when used at a concentration of 50 μM and increases production of P-selectin, von Willebrand factor, and angiopoietin-2 in HCAECs, as well as neutrophil and platelet adherence, when used at a concentration of 10 μM.{43481,43482} 2-chloro Palmitic acid (10-50 μM) also induces apoptosis in THP-1 cells and primary human monocytes and increases caspase-3 activity in THP-1 cells.{43483}
Brand:CaymanSKU:26107 - 5 mgAvailable on backorder
2-chloro Stearic acid is a bioactive fatty acid that accumulates in primary human monocytes and neutrophils as well as murine neutrophils stimulated with phorbol 12-myristate 13-acetate (PMA; Item No. 10008014).{43483,43363} It induces DNA release from primary human neutrophils.{43363} 2-chloro Stearic acid is toxic to C. quinquefasciatus larvae (LC50 = <1 ppm).{36947}
Brand:CaymanSKU:26108 - 1 mgAvailable on backorder
2-chloro Stearic acid is a bioactive fatty acid that accumulates in primary human monocytes and neutrophils as well as murine neutrophils stimulated with phorbol 12-myristate 13-acetate (PMA; Item No. 10008014).{43483,43363} It induces DNA release from primary human neutrophils.{43363} 2-chloro Stearic acid is toxic to C. quinquefasciatus larvae (LC50 = <1 ppm).{36947}
Brand:CaymanSKU:26108 - 10 mgAvailable on backorder
2-chloro Stearic acid is a bioactive fatty acid that accumulates in primary human monocytes and neutrophils as well as murine neutrophils stimulated with phorbol 12-myristate 13-acetate (PMA; Item No. 10008014).{43483,43363} It induces DNA release from primary human neutrophils.{43363} 2-chloro Stearic acid is toxic to C. quinquefasciatus larvae (LC50 = <1 ppm).{36947}
Brand:CaymanSKU:26108 - 25 mgAvailable on backorder
2-chloro Stearic acid is a bioactive fatty acid that accumulates in primary human monocytes and neutrophils as well as murine neutrophils stimulated with phorbol 12-myristate 13-acetate (PMA; Item No. 10008014).{43483,43363} It induces DNA release from primary human neutrophils.{43363} 2-chloro Stearic acid is toxic to C. quinquefasciatus larvae (LC50 = <1 ppm).{36947}
Brand:CaymanSKU:26108 - 5 mgAvailable on backorder
Adenosine receptors are a family of G protein-coupled receptors that display distinct patterns of ligand binding and tissue distribution, regulating a variety of physiological functions. 2-chloro-3-Deazaadenosine is a stable analog of adenosine that acts as an agonist for adenosine receptors (Ki = 0.3, 0.08, 25.5, and 1.9 μM for A1, A2A, A2B, and A3 receptors, respectively).{19450,19451} It can block neurotransmitter release by activating A1 receptors or inhibit neurotransmission by activating A2A receptors.{19446,19453,19448} 2-chloro-3-Deazaadenosine blocks seizures by stimulating A1 receptors.{19449,19452}
Brand:CaymanSKU:9000787 - 1 mgAvailable on backorder
Adenosine receptors are a family of G protein-coupled receptors that display distinct patterns of ligand binding and tissue distribution, regulating a variety of physiological functions. 2-chloro-3-Deazaadenosine is a stable analog of adenosine that acts as an agonist for adenosine receptors (Ki = 0.3, 0.08, 25.5, and 1.9 μM for A1, A2A, A2B, and A3 receptors, respectively).{19450,19451} It can block neurotransmitter release by activating A1 receptors or inhibit neurotransmission by activating A2A receptors.{19446,19453,19448} 2-chloro-3-Deazaadenosine blocks seizures by stimulating A1 receptors.{19449,19452}
Brand:CaymanSKU:9000787 - 10 mgAvailable on backorder
Adenosine receptors are a family of G protein-coupled receptors that display distinct patterns of ligand binding and tissue distribution, regulating a variety of physiological functions. 2-chloro-3-Deazaadenosine is a stable analog of adenosine that acts as an agonist for adenosine receptors (Ki = 0.3, 0.08, 25.5, and 1.9 μM for A1, A2A, A2B, and A3 receptors, respectively).{19450,19451} It can block neurotransmitter release by activating A1 receptors or inhibit neurotransmission by activating A2A receptors.{19446,19453,19448} 2-chloro-3-Deazaadenosine blocks seizures by stimulating A1 receptors.{19449,19452}
Brand:CaymanSKU:9000787 - 5 mgAvailable on backorder
Carbohydrates conjugated with 2-chloro-4-nitrophenyl (CNP) serve as chromogenic substrates in assays for enzymes that release CNP from the conjugated carbohydrate.{27183,27182} For example, CNP-β-D-maltoheptaoside and CNP-α-maltotrioside are chromogenic substrates for α-amylase.{27181,27186} 2-Chloro-4-nitrophenyl-α-D-glucopyranoside is a conjugate of CNP and α-D-glucose. The related conjugate between CNP and β-D-glucose, 2-chloro-4-nitrophenyl β-D-glucopyranoside, is used as a chromogenic substrate for glycosyltransferases.{27185,27184} This product is a chromogenic substrate for enzymes that target the linkage between CNP and α-D-glucose.
Brand:CaymanSKU:-Out of stock
Carbohydrates conjugated with 2-chloro-4-nitrophenyl (CNP) serve as chromogenic substrates in assays for enzymes that release CNP from the conjugated carbohydrate.{27183,27182} For example, CNP-β-D-maltoheptaoside and CNP-α-maltotrioside are chromogenic substrates for α-amylase.{27181,27186} 2-Chloro-4-nitrophenyl-α-D-glucopyranoside is a conjugate of CNP and α-D-glucose. The related conjugate between CNP and β-D-glucose, 2-chloro-4-nitrophenyl β-D-glucopyranoside, is used as a chromogenic substrate for glycosyltransferases.{27185,27184} This product is a chromogenic substrate for enzymes that target the linkage between CNP and α-D-glucose.
Brand:CaymanSKU:-Out of stock