Cayman
Showing 43051–43200 of 45550 results
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Tubeimoside I is a natural triterpenoid saponin isolated from the medicinal herb B. paniculatum which possesses broad anticancer activity.{39096,39097,39098,39099} Tubeimoside I exhibits antiproliferative activity against hepatoma HepG2 cells (IC50 = 15.5 μM) and induces nuclear condensation and fragmentation, cell cycle arrest, mitochondrial membrane disruption, and activation of caspase-3 and caspase-9.{39096} Treatment of HeLa cells with tubeimoside I (IC50 = 25 μM) similarly initiates mitochondrial dysfunction, endoplasmic reticulum stress, and cytoskeletal rearrangement.{39097} In vivo, tubeimoside I (5 mg/kg) administration to nude mice with flank xenografts of human large-cell lung carcinoma cells decreases tumor volume and microvessel density.{39098} It also decreases metastasis of breast cancer cell line MDA-MB-231 in vivo by decreasing expression of C-X-C chemokine receptor type 4 (CXCR4).{39099}
Brand:CaymanSKU:22276 -Out of stock
Tubeimoside I is a natural triterpenoid saponin isolated from the medicinal herb B. paniculatum which possesses broad anticancer activity.{39096,39097,39098,39099} Tubeimoside I exhibits antiproliferative activity against hepatoma HepG2 cells (IC50 = 15.5 μM) and induces nuclear condensation and fragmentation, cell cycle arrest, mitochondrial membrane disruption, and activation of caspase-3 and caspase-9.{39096} Treatment of HeLa cells with tubeimoside I (IC50 = 25 μM) similarly initiates mitochondrial dysfunction, endoplasmic reticulum stress, and cytoskeletal rearrangement.{39097} In vivo, tubeimoside I (5 mg/kg) administration to nude mice with flank xenografts of human large-cell lung carcinoma cells decreases tumor volume and microvessel density.{39098} It also decreases metastasis of breast cancer cell line MDA-MB-231 in vivo by decreasing expression of C-X-C chemokine receptor type 4 (CXCR4).{39099}
Brand:CaymanSKU:22276 -Out of stock
Tubeimoside I is a natural triterpenoid saponin isolated from the medicinal herb B. paniculatum which possesses broad anticancer activity.{39096,39097,39098,39099} Tubeimoside I exhibits antiproliferative activity against hepatoma HepG2 cells (IC50 = 15.5 μM) and induces nuclear condensation and fragmentation, cell cycle arrest, mitochondrial membrane disruption, and activation of caspase-3 and caspase-9.{39096} Treatment of HeLa cells with tubeimoside I (IC50 = 25 μM) similarly initiates mitochondrial dysfunction, endoplasmic reticulum stress, and cytoskeletal rearrangement.{39097} In vivo, tubeimoside I (5 mg/kg) administration to nude mice with flank xenografts of human large-cell lung carcinoma cells decreases tumor volume and microvessel density.{39098} It also decreases metastasis of breast cancer cell line MDA-MB-231 in vivo by decreasing expression of C-X-C chemokine receptor type 4 (CXCR4).{39099}
Brand:CaymanSKU:22276 -Out of stock
Tubeimoside I is a natural triterpenoid saponin isolated from the medicinal herb B. paniculatum which possesses broad anticancer activity.{39096,39097,39098,39099} Tubeimoside I exhibits antiproliferative activity against hepatoma HepG2 cells (IC50 = 15.5 μM) and induces nuclear condensation and fragmentation, cell cycle arrest, mitochondrial membrane disruption, and activation of caspase-3 and caspase-9.{39096} Treatment of HeLa cells with tubeimoside I (IC50 = 25 μM) similarly initiates mitochondrial dysfunction, endoplasmic reticulum stress, and cytoskeletal rearrangement.{39097} In vivo, tubeimoside I (5 mg/kg) administration to nude mice with flank xenografts of human large-cell lung carcinoma cells decreases tumor volume and microvessel density.{39098} It also decreases metastasis of breast cancer cell line MDA-MB-231 in vivo by decreasing expression of C-X-C chemokine receptor type 4 (CXCR4).{39099}
Brand:CaymanSKU:22276 -Out of stock
TUG-770 is an agonist of free fatty acid receptor 1 (FFA1/GPR40; EC50 = 6.16 nM for a response to the full FFA1 agonist TUG-20 in a calcium assay in 1311N1 cells).{37557} It is selective for FFA1 over FFA2 (EC50 = 933 nM in a BRET assay). It reduces glucose levels in mice in an intraperitoneal glucose tolerance test in a dose-dependent manner with a maximal reduction at a dose of 50 mg/kg. It also reduces glucose levels in an oral glucose tolerance test in a diet-induced obesity mouse model for at least 29 days.
Brand:CaymanSKU:22131 -Out of stock
TUG-770 is an agonist of free fatty acid receptor 1 (FFA1/GPR40; EC50 = 6.16 nM for a response to the full FFA1 agonist TUG-20 in a calcium assay in 1311N1 cells).{37557} It is selective for FFA1 over FFA2 (EC50 = 933 nM in a BRET assay). It reduces glucose levels in mice in an intraperitoneal glucose tolerance test in a dose-dependent manner with a maximal reduction at a dose of 50 mg/kg. It also reduces glucose levels in an oral glucose tolerance test in a diet-induced obesity mouse model for at least 29 days.
Brand:CaymanSKU:22131 -Out of stock
TUG-770 is an agonist of free fatty acid receptor 1 (FFA1/GPR40; EC50 = 6.16 nM for a response to the full FFA1 agonist TUG-20 in a calcium assay in 1311N1 cells).{37557} It is selective for FFA1 over FFA2 (EC50 = 933 nM in a BRET assay). It reduces glucose levels in mice in an intraperitoneal glucose tolerance test in a dose-dependent manner with a maximal reduction at a dose of 50 mg/kg. It also reduces glucose levels in an oral glucose tolerance test in a diet-induced obesity mouse model for at least 29 days.
Brand:CaymanSKU:22131 -Out of stock
TUG-770 is an agonist of free fatty acid receptor 1 (FFA1/GPR40; EC50 = 6.16 nM for a response to the full FFA1 agonist TUG-20 in a calcium assay in 1311N1 cells).{37557} It is selective for FFA1 over FFA2 (EC50 = 933 nM in a BRET assay). It reduces glucose levels in mice in an intraperitoneal glucose tolerance test in a dose-dependent manner with a maximal reduction at a dose of 50 mg/kg. It also reduces glucose levels in an oral glucose tolerance test in a diet-induced obesity mouse model for at least 29 days.
Brand:CaymanSKU:22131 -Out of stock
GPR120 (free fatty acid receptor 4; FFAR4) is a G protein-coupled receptor (GPCR) expressed in intestine, adipocytes, and pro-inflammatory macrophages that is activated by long chain free fatty acids.{27421,22326} ω-3 Fatty acids, such as docosahexaenoic acid (Item No. 90310) and eicosapentaenoic acid (Item No. 90110), initiate GPR120 signaling resulting in inhibition of toll-like receptor and TNF-α inflammatory signaling pathways in a β-arrestin2/TAB1 dependent manner.{22326} TUG-891 is a potent and selective agonist of GPR120 with pEC50 values of 7.36 and 7.77 for human and mouse GPR120, respectively. It activates GPR40 (FFAR1) with a pEC50 value of 4.19 and shows no activity at GPR41 (FFAR3) or GPR43 (FFAR2).{28006}
Brand:CaymanSKU:-Out of stock
GPR120 (free fatty acid receptor 4; FFAR4) is a G protein-coupled receptor (GPCR) expressed in intestine, adipocytes, and pro-inflammatory macrophages that is activated by long chain free fatty acids.{27421,22326} ω-3 Fatty acids, such as docosahexaenoic acid (Item No. 90310) and eicosapentaenoic acid (Item No. 90110), initiate GPR120 signaling resulting in inhibition of toll-like receptor and TNF-α inflammatory signaling pathways in a β-arrestin2/TAB1 dependent manner.{22326} TUG-891 is a potent and selective agonist of GPR120 with pEC50 values of 7.36 and 7.77 for human and mouse GPR120, respectively. It activates GPR40 (FFAR1) with a pEC50 value of 4.19 and shows no activity at GPR41 (FFAR3) or GPR43 (FFAR2).{28006}
Brand:CaymanSKU:-Out of stock
GPR120 (free fatty acid receptor 4; FFAR4) is a G protein-coupled receptor (GPCR) expressed in intestine, adipocytes, and pro-inflammatory macrophages that is activated by long chain free fatty acids.{27421,22326} ω-3 Fatty acids, such as docosahexaenoic acid (Item No. 90310) and eicosapentaenoic acid (Item No. 90110), initiate GPR120 signaling resulting in inhibition of toll-like receptor and TNF-α inflammatory signaling pathways in a β-arrestin2/TAB1 dependent manner.{22326} TUG-891 is a potent and selective agonist of GPR120 with pEC50 values of 7.36 and 7.77 for human and mouse GPR120, respectively. It activates GPR40 (FFAR1) with a pEC50 value of 4.19 and shows no activity at GPR41 (FFAR3) or GPR43 (FFAR2).{28006}
Brand:CaymanSKU:-Out of stock
GPR120 (free fatty acid receptor 4; FFAR4) is a G protein-coupled receptor (GPCR) expressed in intestine, adipocytes, and pro-inflammatory macrophages that is activated by long chain free fatty acids.{27421,22326} ω-3 Fatty acids, such as docosahexaenoic acid (Item No. 90310) and eicosapentaenoic acid (Item No. 90110), initiate GPR120 signaling resulting in inhibition of toll-like receptor and TNF-α inflammatory signaling pathways in a β-arrestin2/TAB1 dependent manner.{22326} TUG-891 is a potent and selective agonist of GPR120 with pEC50 values of 7.36 and 7.77 for human and mouse GPR120, respectively. It activates GPR40 (FFAR1) with a pEC50 value of 4.19 and shows no activity at GPR41 (FFAR3) or GPR43 (FFAR2).{28006}
Brand:CaymanSKU:-Out of stock
Tulathromycin A is a macrolide antibiotic that inhibits bacterial protein synthesis (IC50 = 0.26 µM) by targeting the 50S ribosomal subunit, blocking the progression of nascent polypeptide chains.{27769} It is effective against M. haemolytica and P. multocida (MICs = 2 and 0.5 µg/ml, respectively), which cause respiratory tract infections in cattle and swine.{27769}
Brand:CaymanSKU:-Available on backorder
Tulathromycin A is a macrolide antibiotic that inhibits bacterial protein synthesis (IC50 = 0.26 µM) by targeting the 50S ribosomal subunit, blocking the progression of nascent polypeptide chains.{27769} It is effective against M. haemolytica and P. multocida (MICs = 2 and 0.5 µg/ml, respectively), which cause respiratory tract infections in cattle and swine.{27769}
Brand:CaymanSKU:-Available on backorder
Tulathromycin A is a macrolide antibiotic that inhibits bacterial protein synthesis (IC50 = 0.26 µM) by targeting the 50S ribosomal subunit, blocking the progression of nascent polypeptide chains.{27769} It is effective against M. haemolytica and P. multocida (MICs = 2 and 0.5 µg/ml, respectively), which cause respiratory tract infections in cattle and swine.{27769}
Brand:CaymanSKU:-Available on backorder
Tulathromycin A is a macrolide antibiotic that inhibits bacterial protein synthesis (IC50 = 0.26 µM) by targeting the 50S ribosomal subunit, blocking the progression of nascent polypeptide chains.{27769} It is effective against M. haemolytica and P. multocida (MICs = 2 and 0.5 µg/ml, respectively), which cause respiratory tract infections in cattle and swine.{27769}
Brand:CaymanSKU:-Available on backorder
N-linked glycosylation is a highly regulated post-translational modification that is involved in protein folding and conformation, oligomerization, sorting, cell-cell interactions, and targeting of proteins to sub- or extra-cellular locations. It is initiated in the endoplastic reticulum with the transfer of a carbohydrate moiety to an asparagine residue within a specific amino acid consensus sequence and then further processed in the Golgi whereupon a mature glycoprotein is exported through the secretory machinery to the plasma membrane. Tunicamycin, a mixture of nucleoside antibiotics, is a specific inhibitor of N-linked glycoslylation that blocks the first step of glycoprotein synthesis thereby inducing protein unfolding. At 500 nM, it can impair the function of several receptor tyrosine kinases, including EGFR, ErbB2, ErbB3, and IGF-IR.{20913} Also at 500 nM, it radiosensitizes U251 glioma and BXPC3 pancreatic adenocarcinoma cells to chemotherapy.{20913} Tunicamycin impairs ALK phosphorylation and disrupts pro-survival signaling and cell viability in various neuroblastoma cell lines (IC50s range from 20 – 500 nM).{20914} Tunicamycin can also inhibit protein palmitoylation.{20912}
Brand:CaymanSKU:11445 - 1 mgAvailable on backorder
N-linked glycosylation is a highly regulated post-translational modification that is involved in protein folding and conformation, oligomerization, sorting, cell-cell interactions, and targeting of proteins to sub- or extra-cellular locations. It is initiated in the endoplastic reticulum with the transfer of a carbohydrate moiety to an asparagine residue within a specific amino acid consensus sequence and then further processed in the Golgi whereupon a mature glycoprotein is exported through the secretory machinery to the plasma membrane. Tunicamycin, a mixture of nucleoside antibiotics, is a specific inhibitor of N-linked glycoslylation that blocks the first step of glycoprotein synthesis thereby inducing protein unfolding. At 500 nM, it can impair the function of several receptor tyrosine kinases, including EGFR, ErbB2, ErbB3, and IGF-IR.{20913} Also at 500 nM, it radiosensitizes U251 glioma and BXPC3 pancreatic adenocarcinoma cells to chemotherapy.{20913} Tunicamycin impairs ALK phosphorylation and disrupts pro-survival signaling and cell viability in various neuroblastoma cell lines (IC50s range from 20 – 500 nM).{20914} Tunicamycin can also inhibit protein palmitoylation.{20912}
Brand:CaymanSKU:11445 - 10 mgAvailable on backorder
N-linked glycosylation is a highly regulated post-translational modification that is involved in protein folding and conformation, oligomerization, sorting, cell-cell interactions, and targeting of proteins to sub- or extra-cellular locations. It is initiated in the endoplastic reticulum with the transfer of a carbohydrate moiety to an asparagine residue within a specific amino acid consensus sequence and then further processed in the Golgi whereupon a mature glycoprotein is exported through the secretory machinery to the plasma membrane. Tunicamycin, a mixture of nucleoside antibiotics, is a specific inhibitor of N-linked glycoslylation that blocks the first step of glycoprotein synthesis thereby inducing protein unfolding. At 500 nM, it can impair the function of several receptor tyrosine kinases, including EGFR, ErbB2, ErbB3, and IGF-IR.{20913} Also at 500 nM, it radiosensitizes U251 glioma and BXPC3 pancreatic adenocarcinoma cells to chemotherapy.{20913} Tunicamycin impairs ALK phosphorylation and disrupts pro-survival signaling and cell viability in various neuroblastoma cell lines (IC50s range from 20 – 500 nM).{20914} Tunicamycin can also inhibit protein palmitoylation.{20912}
Brand:CaymanSKU:11445 - 5 mgAvailable on backorder
TW-37 is an inhibitor of the Bcl-2 family proteins Bcl-2, Mcl-1, and Bcl-xL (Kis = 120, 260, and 1,100 nM, respectively).{33641,33642} It induces apoptosis, inhibits migration and capillary sprouting, and blocks the expression of the angiogenic chemokines CXCL1 and CXCL8 in endothelial cells.{33642} TW-37 decreases the density of functional human microvessels in the severe combined immunodeficient mouse model of human angiogenesis when administered intravenously.{33642} It has apoptotic action against leukemia, lymphoma, and pancreatic cancer cells.{25683}
Brand:CaymanSKU:20999 -Out of stock
TW-37 is an inhibitor of the Bcl-2 family proteins Bcl-2, Mcl-1, and Bcl-xL (Kis = 120, 260, and 1,100 nM, respectively).{33641,33642} It induces apoptosis, inhibits migration and capillary sprouting, and blocks the expression of the angiogenic chemokines CXCL1 and CXCL8 in endothelial cells.{33642} TW-37 decreases the density of functional human microvessels in the severe combined immunodeficient mouse model of human angiogenesis when administered intravenously.{33642} It has apoptotic action against leukemia, lymphoma, and pancreatic cancer cells.{25683}
Brand:CaymanSKU:20999 -Out of stock
TW-37 is an inhibitor of the Bcl-2 family proteins Bcl-2, Mcl-1, and Bcl-xL (Kis = 120, 260, and 1,100 nM, respectively).{33641,33642} It induces apoptosis, inhibits migration and capillary sprouting, and blocks the expression of the angiogenic chemokines CXCL1 and CXCL8 in endothelial cells.{33642} TW-37 decreases the density of functional human microvessels in the severe combined immunodeficient mouse model of human angiogenesis when administered intravenously.{33642} It has apoptotic action against leukemia, lymphoma, and pancreatic cancer cells.{25683}
Brand:CaymanSKU:20999 -Out of stock
TW-37 is an inhibitor of the Bcl-2 family proteins Bcl-2, Mcl-1, and Bcl-xL (Kis = 120, 260, and 1,100 nM, respectively).{33641,33642} It induces apoptosis, inhibits migration and capillary sprouting, and blocks the expression of the angiogenic chemokines CXCL1 and CXCL8 in endothelial cells.{33642} TW-37 decreases the density of functional human microvessels in the severe combined immunodeficient mouse model of human angiogenesis when administered intravenously.{33642} It has apoptotic action against leukemia, lymphoma, and pancreatic cancer cells.{25683}
Brand:CaymanSKU:20999 -Out of stock
Glycogen synthase kinase 3 (GSK3) is a serine/threonine protein kinase that is inhibited by a number of extracellular stimuli such as insulin, growth factors, cell specification factors, and cell adhesion. Its activity regulates many cell functions including cell division, apoptosis, and inflammation. TWS119 is a 4,6 disubstituted pyrrolopyrimidine that potently inhibits GSK3β with an IC50 value of 30 nM.{16500} At 400 nM, TWS119 induces neurogenesis in mouse embryonic stem cells making it a useful tool to regulate stem cell self-renewal and differentiation.{16500}
Brand:CaymanSKU:10011251 - 1 mgAvailable on backorder
Glycogen synthase kinase 3 (GSK3) is a serine/threonine protein kinase that is inhibited by a number of extracellular stimuli such as insulin, growth factors, cell specification factors, and cell adhesion. Its activity regulates many cell functions including cell division, apoptosis, and inflammation. TWS119 is a 4,6 disubstituted pyrrolopyrimidine that potently inhibits GSK3β with an IC50 value of 30 nM.{16500} At 400 nM, TWS119 induces neurogenesis in mouse embryonic stem cells making it a useful tool to regulate stem cell self-renewal and differentiation.{16500}
Brand:CaymanSKU:10011251 - 10 mgAvailable on backorder
Glycogen synthase kinase 3 (GSK3) is a serine/threonine protein kinase that is inhibited by a number of extracellular stimuli such as insulin, growth factors, cell specification factors, and cell adhesion. Its activity regulates many cell functions including cell division, apoptosis, and inflammation. TWS119 is a 4,6 disubstituted pyrrolopyrimidine that potently inhibits GSK3β with an IC50 value of 30 nM.{16500} At 400 nM, TWS119 induces neurogenesis in mouse embryonic stem cells making it a useful tool to regulate stem cell self-renewal and differentiation.{16500}
Brand:CaymanSKU:10011251 - 25 mgAvailable on backorder
Glycogen synthase kinase 3 (GSK3) is a serine/threonine protein kinase that is inhibited by a number of extracellular stimuli such as insulin, growth factors, cell specification factors, and cell adhesion. Its activity regulates many cell functions including cell division, apoptosis, and inflammation. TWS119 is a 4,6 disubstituted pyrrolopyrimidine that potently inhibits GSK3β with an IC50 value of 30 nM.{16500} At 400 nM, TWS119 induces neurogenesis in mouse embryonic stem cells making it a useful tool to regulate stem cell self-renewal and differentiation.{16500}
Brand:CaymanSKU:10011251 - 5 mgAvailable on backorder
TX-1918 is a cell-permeable tyrphostin derivative that inhibits eukaryotic elongation factor-2 kinase (eEF-2K; IC50 = 440 nM).{33394} It inhibits Src, PKA, PKC, and EGFR kinases at much higher concentrations (IC50s = 4.4, 44, 44, and 440 µM, respectively).{33394} TX-1918 disrupts the proliferation of HepG2 and HCT116 tumor cells (EC50s = 2.07 and 230 µM, respectively) with ≥5,000-fold and ≥90-fold reduced mitochondrial- and hepato-toxicity, respectively when compared with the tyrphostin AG-17 (Item No. 10010248).{33394}
Brand:CaymanSKU:20840 -Out of stock
TX-1918 is a cell-permeable tyrphostin derivative that inhibits eukaryotic elongation factor-2 kinase (eEF-2K; IC50 = 440 nM).{33394} It inhibits Src, PKA, PKC, and EGFR kinases at much higher concentrations (IC50s = 4.4, 44, 44, and 440 µM, respectively).{33394} TX-1918 disrupts the proliferation of HepG2 and HCT116 tumor cells (EC50s = 2.07 and 230 µM, respectively) with ≥5,000-fold and ≥90-fold reduced mitochondrial- and hepato-toxicity, respectively when compared with the tyrphostin AG-17 (Item No. 10010248).{33394}
Brand:CaymanSKU:20840 -Out of stock
TX-1918 is a cell-permeable tyrphostin derivative that inhibits eukaryotic elongation factor-2 kinase (eEF-2K; IC50 = 440 nM).{33394} It inhibits Src, PKA, PKC, and EGFR kinases at much higher concentrations (IC50s = 4.4, 44, 44, and 440 µM, respectively).{33394} TX-1918 disrupts the proliferation of HepG2 and HCT116 tumor cells (EC50s = 2.07 and 230 µM, respectively) with ≥5,000-fold and ≥90-fold reduced mitochondrial- and hepato-toxicity, respectively when compared with the tyrphostin AG-17 (Item No. 10010248).{33394}
Brand:CaymanSKU:20840 -Out of stock
TX1-85-1 is an inhibitor of the epidermal growth factor receptor tyrosine kinase ErbB3 (IC50 = 23 nM).{27814} It also binds to ErbB2, Lyn, and several other Src family kinases in a live cell chemical proteomics assay when used at a concentration of 2 µM. TX1-85-1 inhibits phosphorylation of Akt and ERK1/2 in ErbB3-dependent HCC2935 and OVCAR-8 cells when used at concentrations of 5 and 2 µM, respectively. However, it does not inhibit proliferation of ErbB3-dependent PC9 GR4, HCC827 GR8, or OVCAR-8 cells (EC50s = ≥10 µM).
Brand:CaymanSKU:-Available on backorder
TX1-85-1 is an inhibitor of the epidermal growth factor receptor tyrosine kinase ErbB3 (IC50 = 23 nM).{27814} It also binds to ErbB2, Lyn, and several other Src family kinases in a live cell chemical proteomics assay when used at a concentration of 2 µM. TX1-85-1 inhibits phosphorylation of Akt and ERK1/2 in ErbB3-dependent HCC2935 and OVCAR-8 cells when used at concentrations of 5 and 2 µM, respectively. However, it does not inhibit proliferation of ErbB3-dependent PC9 GR4, HCC827 GR8, or OVCAR-8 cells (EC50s = ≥10 µM).
Brand:CaymanSKU:-Available on backorder
TX1-85-1 is an inhibitor of the epidermal growth factor receptor tyrosine kinase ErbB3 (IC50 = 23 nM).{27814} It also binds to ErbB2, Lyn, and several other Src family kinases in a live cell chemical proteomics assay when used at a concentration of 2 µM. TX1-85-1 inhibits phosphorylation of Akt and ERK1/2 in ErbB3-dependent HCC2935 and OVCAR-8 cells when used at concentrations of 5 and 2 µM, respectively. However, it does not inhibit proliferation of ErbB3-dependent PC9 GR4, HCC827 GR8, or OVCAR-8 cells (EC50s = ≥10 µM).
Brand:CaymanSKU:-Available on backorder
TY 52156 is a selective sphingosine-1-phosphate receptor 3 (SIP3) antagonist (Ki = 110 nM).{31203} It preferentially inhibits the S1P-induced increase in intracellular calcium in Chinese hamster ovary cells expressing S1P3 over cell expressing S1P1, S1P2, or S1P4.{31203} TY 52156 has been shown to suppress FTY720-induced S1P3 receptor-mediated coronary flow in isolated perfused rat hearts.{31203} TY 52156 can also inhibit S1P-induced breast cancer stem cell expansion in vitro.{31202}
Brand:CaymanSKU:-Available on backorder
TY 52156 is a selective sphingosine-1-phosphate receptor 3 (SIP3) antagonist (Ki = 110 nM).{31203} It preferentially inhibits the S1P-induced increase in intracellular calcium in Chinese hamster ovary cells expressing S1P3 over cell expressing S1P1, S1P2, or S1P4.{31203} TY 52156 has been shown to suppress FTY720-induced S1P3 receptor-mediated coronary flow in isolated perfused rat hearts.{31203} TY 52156 can also inhibit S1P-induced breast cancer stem cell expansion in vitro.{31202}
Brand:CaymanSKU:-Available on backorder
TY 52156 is a selective sphingosine-1-phosphate receptor 3 (SIP3) antagonist (Ki = 110 nM).{31203} It preferentially inhibits the S1P-induced increase in intracellular calcium in Chinese hamster ovary cells expressing S1P3 over cell expressing S1P1, S1P2, or S1P4.{31203} TY 52156 has been shown to suppress FTY720-induced S1P3 receptor-mediated coronary flow in isolated perfused rat hearts.{31203} TY 52156 can also inhibit S1P-induced breast cancer stem cell expansion in vitro.{31202}
Brand:CaymanSKU:-Available on backorder
TY 52156 is a selective sphingosine-1-phosphate receptor 3 (SIP3) antagonist (Ki = 110 nM).{31203} It preferentially inhibits the S1P-induced increase in intracellular calcium in Chinese hamster ovary cells expressing S1P3 over cell expressing S1P1, S1P2, or S1P4.{31203} TY 52156 has been shown to suppress FTY720-induced S1P3 receptor-mediated coronary flow in isolated perfused rat hearts.{31203} TY 52156 can also inhibit S1P-induced breast cancer stem cell expansion in vitro.{31202}
Brand:CaymanSKU:-Available on backorder
Tylosin is a macrolide antibiotic produced by S. fradiae that has bacteriostatic activity against Gram-positive bacteria.{37111} It is a mixture of tylosin A, B, C, and D, with tylosin A contributing 80% of its bacteriostatic activity. Tylosin has MIC values of 9.6, 16.4, 0.1, 1, and 0.5 μg/ml for F. necrophorum, A. pyogenes, M. gallisepticum, S. aureus, and S. uberis, respectively.{37112},{37113},{37114} Formulations containing tylosin have been used for the prevention of liver abscesses in cattle.{37113} Tylosin is an environmental contaminant because it is not fully metabolized by treated livestock and enters the environment through manure-based fertilizers.{37115}
Brand:CaymanSKU:22599 -Out of stock
Tylosin is a macrolide antibiotic produced by S. fradiae that has bacteriostatic activity against Gram-positive bacteria.{37111} It is a mixture of tylosin A, B, C, and D, with tylosin A contributing 80% of its bacteriostatic activity. Tylosin has MIC values of 9.6, 16.4, 0.1, 1, and 0.5 μg/ml for F. necrophorum, A. pyogenes, M. gallisepticum, S. aureus, and S. uberis, respectively.{37112},{37113},{37114} Formulations containing tylosin have been used for the prevention of liver abscesses in cattle.{37113} Tylosin is an environmental contaminant because it is not fully metabolized by treated livestock and enters the environment through manure-based fertilizers.{37115}
Brand:CaymanSKU:22599 -Out of stock
Tylosin is a macrolide antibiotic produced by S. fradiae that has bacteriostatic activity against Gram-positive bacteria.{37111} It is a mixture of tylosin A, B, C, and D, with tylosin A contributing 80% of its bacteriostatic activity. Tylosin has MIC values of 9.6, 16.4, 0.1, 1, and 0.5 μg/ml for F. necrophorum, A. pyogenes, M. gallisepticum, S. aureus, and S. uberis, respectively.{37112},{37113},{37114} Formulations containing tylosin have been used for the prevention of liver abscesses in cattle.{37113} Tylosin is an environmental contaminant because it is not fully metabolized by treated livestock and enters the environment through manure-based fertilizers.{37115}
Brand:CaymanSKU:22599 -Out of stock
Tyr-α-CGRP is an N-terminal extended tyrosinated analogue of α-calcitonin gene-related peptide (α-CGRP; Item No. 24405).{38807} It binds to amylin receptors AMY1 and AMY3 in COS-7 cells expressing the human receptors (IC50s = 141 and 1.86 nM, respectively).{38808} Tyr-α-CGRP also binds to and stimulates cAMP accumulation in rat L6 myocytes (IC50 = 4 nM; EC50 = 12 nM).{38807} It also binds to rat brain and spleen membrane preparations (IC50s = 0.2 and 0.5 nM, respectively), induces positive chronotropic and inotropic effects in isolated right and left guinea pig atria (EC50s = 282 and 74 nM, respectively), and inhibits the twitch response in rat vas deferens (EC50 = 1.9 nM).{38809}
Brand:CaymanSKU:24724 - 500 µgAvailable on backorder
Tyramine is a tyrosine-derived endogenous and dietary monoamine and trace amine-associated receptor 1 (TAAR1) agonist.{24428,22581,30099} It activates TAAR1 (EC50s = 0.08, 0.69, and 2.26 µM for rat, mouse, and human-rat chimera receptors, respectively).{24428} Tyramine also inhibits the release of norepinephrine and dopamine in isolated rat caudate nucleus (IC50s = 40.6 and 119 nM, respectively).{26354}
Brand:CaymanSKU:-Available on backorder
Tyramine is a tyrosine-derived endogenous and dietary monoamine and trace amine-associated receptor 1 (TAAR1) agonist.{24428,22581,30099} It activates TAAR1 (EC50s = 0.08, 0.69, and 2.26 µM for rat, mouse, and human-rat chimera receptors, respectively).{24428} Tyramine also inhibits the release of norepinephrine and dopamine in isolated rat caudate nucleus (IC50s = 40.6 and 119 nM, respectively).{26354}
Brand:CaymanSKU:-Available on backorder
Tyramine is a tyrosine-derived endogenous and dietary monoamine and trace amine-associated receptor 1 (TAAR1) agonist.{24428,22581,30099} It activates TAAR1 (EC50s = 0.08, 0.69, and 2.26 µM for rat, mouse, and human-rat chimera receptors, respectively).{24428} Tyramine also inhibits the release of norepinephrine and dopamine in isolated rat caudate nucleus (IC50s = 40.6 and 119 nM, respectively).{26354}
Brand:CaymanSKU:-Available on backorder
Tyramine is a tyrosine-derived endogenous and dietary monoamine and trace amine-associated receptor 1 (TAAR1) agonist.{24428,22581,30099} It activates TAAR1 (EC50s = 0.08, 0.69, and 2.26 µM for rat, mouse, and human-rat chimera receptors, respectively).{24428} Tyramine also inhibits the release of norepinephrine and dopamine in isolated rat caudate nucleus (IC50s = 40.6 and 119 nM, respectively).{26354}
Brand:CaymanSKU:-Available on backorder
Tyramine-d4 is intended for use as an internal standard for the quantification of tyramine (Item No. 18601) by GC- or LC-MS. Tyramine is a tyrosine-derived endogenous and dietary monoamine and trace amine-associated receptor 1 (TAAR1) agonist.{24428,22581,30099} It activates TAAR1 (EC50s = 0.08, 0.69, and 2.26 µM for rat, mouse, and human-rat chimera receptors, respectively).{24428} Tyramine also inhibits the release of norepinephrine and dopamine in isolated rat caudate nucleus (IC50s = 40.6 and 119 nM, respectively).{26354}
Brand:CaymanSKU:28531 - 5 mgAvailable on backorder
Tyrocidine complex is a mixture of cyclic decapeptides originally isolated from B. brevis.{42458,42459} It is active against Gram-positive and Gram-negative bacteria.{42458} It forms a complex with single- and double-stranded DNA to inhibit RNA synthesis.{42460}
Brand:CaymanSKU:25655 - 25 mgAvailable on backorder
Tyrocidine complex is a mixture of cyclic decapeptides originally isolated from B. brevis.{42458,42459} It is active against Gram-positive and Gram-negative bacteria.{42458} It forms a complex with single- and double-stranded DNA to inhibit RNA synthesis.{42460}
Brand:CaymanSKU:25655 - 5 mgAvailable on backorder
Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the synthesis of the catecholamines dopamine and norepinephrine. TH antibodies can therefore be used as markers for dopaminergic and noradrenergic neurons in a variety of applications including depression, schizophrenia, Parkinson’s disease, and drug abuse.{14414,14416,14417} TH antibodies can also be used to explore basic mechanisms of dopamine and norepinephrine signalling.{14444,14443,14439} The activity of TH is also regulated by phosphorylation.{14441,14440,14442} Phospho-specific antibodies for the phosphorylation sites on TH can be used to great effect in studying this regulation and in identifying the cells in which TH phosphorylation occurs.
Brand:CaymanSKU:10009413 - 1 eaAvailable on backorder
Antigen: phosphopeptide corresponding to amino acid residues surrounding phospho-Ser31 of rat TH · Host: rabbit · Cross Reactivity: (+) mouse and rat TH · Applications: WB, IF (frozen sections), and IHC (frozen sections)
Brand:CaymanSKU:10009413- 1 eaAvailable on backorder
Antigen: phosphopeptide corresponding to amino acid residues surrounding phospho-Ser31 of rat TH · Host: rabbit · Cross Reactivity: (+) mouse and rat TH · Applications: WB, IF (frozen sections), and IHC (frozen sections)
Brand:CaymanSKU:10009413- 1 ea Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the synthesis of the catecholamines dopamine and norepinephrine. TH antibodies can therefore be used as markers for dopaminergic and noradrenergic neurons in a variety of applications including depression, schizophrenia, Parkinson’s disease, and drug abuse.{14414,14416,14417} TH antibodies can also be used to explore basic mechanisms of dopamine and norepinephrine signaling.{14444,14443,14439} The activity of TH is also regulated by phosphorylation.{14440,14441,14442} Phospho-specific antibodies for the phosphorylation sites on TH can be used to great effect in studying this regulation and in identifying the cells in which TH phosphorylation occurs.
Brand:CaymanSKU:10009414 - 1 eaAvailable on backorder
Antigen: phosphopeptide corresponding to amino acid residues surrounding phospho-Ser40 of rat TH · Host: rabbit · Cross-reactivity: (+) mammalian and non-mammalian species · Applications: WB, IF (frozen sections), and IHC (frozen sections)
Brand:CaymanSKU:10009414- 1 eaAvailable on backorder
Antigen: phosphopeptide corresponding to amino acid residues surrounding phospho-Ser40 of rat TH · Host: rabbit · Cross-reactivity: (+) mammalian and non-mammalian species · Applications: WB, IF (frozen sections), and IHC (frozen sections)
Brand:CaymanSKU:10009414- 1 ea
Immunogen: SDS-denatured rat tyrosine hydroxylase, purified from pheochromocytoma • Host: Rabbit • Species Reactivity: (+) Human, mouse, rat • Applications: ICC, IHC, WB • MW = ~60 kDa
Brand:CaymanSKU:10604- 1 ea Tyrosine hydroxylase (TH) catalyzes the conversion of tyrosine to L-DOPA, which is the rate-limiting step in the biosynthesis of the catecholamines dopamine, norepinephrine, and epinephrine.{56214} It assembles into tetramers, with each monomer comprised of an N-terminal regulatory domain with three serine residues at positions 19, 31, and 40 that are subject to regulatory phosphorylation, a central catalytic domain, and a C-terminal tetramerization domain. TH is expressed in dopaminergic neurons in the olfactory bulb, diencephalon, substantia nigra, ventral tegmental area, and retinal amacrine cells, adrenergic and noradrenergic cells in the hypothalamus, medulla, and locus coeruleus (LC), as well as sympathetic ganglia and adrenal chromaffin cells. Due to its expression in catecholaminergic neurons, TH has been used as a marker of these cells in the brain.{56215} Mutations in TH have been found in patients with tyrosine hydroxylase deficiency, infantile parkinsonism, and progressive infantile encephalopathy.{56216,56217} Cayman’s Tyrosine Hydroxylase (rat, denatured) Polyclonal Antibody can be used for immunocytochemistry (ICC), immunohistochemistry (IHC), and Western Blot (WB) applications. The antibody recognizes TH at approximately 60 kDa from mammalian samples.
Brand:CaymanSKU:10604 - 1 eaAvailable on backorder
Immunogen: SDS-denatured rat tyrosine hydroxylase, purified from pheochromocytoma • Host: Rabbit • Species Reactivity: (+) Human, mouse, rat • Applications: ICC, IHC, WB • MW = ~60 kDa
Brand:CaymanSKU:10604- 1 eaAvailable on backorder
Immunogen: Native rat tyrosine hydroxylase purified from pheochromocytoma • Host: Sheep • Species Reactivity: (+) Human, Mouse, Rabbit, Rat • Applications: ICC, IHC, WB • MW = ~60 kDa
Brand:CaymanSKU:29299- 100 µl Tyrosine hydroxylase (TH) catalyzes the conversion of tyrosine to L-DOPA, which is the rate-limiting step in the biosynthesis of the catecholamines dopamine, norepinephrine, and epinephrine.{56214} It assembles into tetramers, with each monomer comprised of an N-terminal regulatory domain with three serine residues at positions 19, 31, and 40 that are subject to regulatory phosphorylation, a central catalytic domain, and a C-terminal tetramerization domain. TH is expressed in dopaminergic neurons in the olfactory bulb, diencephalon, substantia nigra, ventral tegmental area, and retinal amacrine cells, adrenergic and noradrenergic cells in the hypothalamus, medulla, and locus coeruleus (LC), as well as sympathetic ganglia and adrenal chromaffin cells. Due to its expression in catecholaminergic neurons, TH has been used as a marker of these cells in the brain.{56215} Mutations in TH have been found in patients with tyrosine hydroxylase deficiency, infantile parkinsonism, and progressive infantile encephalopathy.{56216,56217} Cayman’s Tyrosine Hydroxylase (rat, native) Polyclonal Antibody can be used for immunocytochemistry (ICC), immunohistochemistry (IHC), and Western blot (WB) applications. The antibody recognizes TH at approximately 60 kDa from human, mouse, rabbit, and rat samples.
Brand:CaymanSKU:29299 - 100 µlAvailable on backorder
Immunogen: Native rat tyrosine hydroxylase purified from pheochromocytoma • Host: Sheep • Species Reactivity: (+) Human, Mouse, Rabbit, Rat • Applications: ICC, IHC, WB • MW = ~60 kDa
Brand:CaymanSKU:29299- 100 µlAvailable on backorder
Tyrosol is a phenol that has been found in olives and olive oil and has diverse biological activities.{47483,47484,47485,47486} It is fungicidal against H. capsulatum and C. posadasii with minimum fungicidal concentration (MFC) values of 170-710 and 1,420 μg/ml, respectively.{47483} Tyrosol (70-280 mg/kg) increases survival and pulmonary superoxide dismutase (SOD) activity and decreases pulmonary macrophage and neutrophil infiltration, edema, inflammation, and myeloperoxidase (MPO) activity in a mouse model of LPS-induced acute lung injury.{47484} It reduces aqueous humor TNF-α, nitric oxide (NO), and prostaglandin E2 (PGE2; Item No. 14010) levels and cellular infiltration in a rat model of ocular endotoxin-induced uveitis (EIU).{47485} Tyrosol also decreases erythrocyte aggregation, increases the oxygen transport capacity index (OTCI), and abolishes cortical microvascular rarefaction in spontaneously hypertensive rats.{47486}
Brand:CaymanSKU:27600 - 100 gAvailable on backorder
Tyrosol is a phenol that has been found in olives and olive oil and has diverse biological activities.{47483,47484,47485,47486} It is fungicidal against H. capsulatum and C. posadasii with minimum fungicidal concentration (MFC) values of 170-710 and 1,420 μg/ml, respectively.{47483} Tyrosol (70-280 mg/kg) increases survival and pulmonary superoxide dismutase (SOD) activity and decreases pulmonary macrophage and neutrophil infiltration, edema, inflammation, and myeloperoxidase (MPO) activity in a mouse model of LPS-induced acute lung injury.{47484} It reduces aqueous humor TNF-α, nitric oxide (NO), and prostaglandin E2 (PGE2; Item No. 14010) levels and cellular infiltration in a rat model of ocular endotoxin-induced uveitis (EIU).{47485} Tyrosol also decreases erythrocyte aggregation, increases the oxygen transport capacity index (OTCI), and abolishes cortical microvascular rarefaction in spontaneously hypertensive rats.{47486}
Brand:CaymanSKU:27600 - 250 gAvailable on backorder
Tyrosol is a phenol that has been found in olives and olive oil and has diverse biological activities.{47483,47484,47485,47486} It is fungicidal against H. capsulatum and C. posadasii with minimum fungicidal concentration (MFC) values of 170-710 and 1,420 μg/ml, respectively.{47483} Tyrosol (70-280 mg/kg) increases survival and pulmonary superoxide dismutase (SOD) activity and decreases pulmonary macrophage and neutrophil infiltration, edema, inflammation, and myeloperoxidase (MPO) activity in a mouse model of LPS-induced acute lung injury.{47484} It reduces aqueous humor TNF-α, nitric oxide (NO), and prostaglandin E2 (PGE2; Item No. 14010) levels and cellular infiltration in a rat model of ocular endotoxin-induced uveitis (EIU).{47485} Tyrosol also decreases erythrocyte aggregation, increases the oxygen transport capacity index (OTCI), and abolishes cortical microvascular rarefaction in spontaneously hypertensive rats.{47486}
Brand:CaymanSKU:27600 - 500 gAvailable on backorder
Tyrothricin is a polypeptide antibiotic mixture produced by B. brevis.{38058,38059} Tyrothricin is a mixture of tyrocidine and gramicidin that has rapid in vitro bactericidal activity against T. microdentium, T. macrodentium, T. vincentii, T. buccalis, T. mucosum, T. vaginalis, T. cruzi, and L. tropica.{38059} Preclinical studies demonstrate that intravenous use of tyrothricin leads to hemolysis-induced lethality (LD50s = 0.4 and 0.3 mg/kg, in dogs and mice, respectively) and damages liver, kidney, and olfactory tissues. Formulations containing tyrothricin are used topically to treat bacterial skin infections.{38058,38059}
Brand:CaymanSKU:22177 -Out of stock
Tyrothricin is a polypeptide antibiotic mixture produced by B. brevis.{38058,38059} Tyrothricin is a mixture of tyrocidine and gramicidin that has rapid in vitro bactericidal activity against T. microdentium, T. macrodentium, T. vincentii, T. buccalis, T. mucosum, T. vaginalis, T. cruzi, and L. tropica.{38059} Preclinical studies demonstrate that intravenous use of tyrothricin leads to hemolysis-induced lethality (LD50s = 0.4 and 0.3 mg/kg, in dogs and mice, respectively) and damages liver, kidney, and olfactory tissues. Formulations containing tyrothricin are used topically to treat bacterial skin infections.{38058,38059}
Brand:CaymanSKU:22177 -Out of stock
Tyrothricin is a polypeptide antibiotic mixture produced by B. brevis.{38058,38059} Tyrothricin is a mixture of tyrocidine and gramicidin that has rapid in vitro bactericidal activity against T. microdentium, T. macrodentium, T. vincentii, T. buccalis, T. mucosum, T. vaginalis, T. cruzi, and L. tropica.{38059} Preclinical studies demonstrate that intravenous use of tyrothricin leads to hemolysis-induced lethality (LD50s = 0.4 and 0.3 mg/kg, in dogs and mice, respectively) and damages liver, kidney, and olfactory tissues. Formulations containing tyrothricin are used topically to treat bacterial skin infections.{38058,38059}
Brand:CaymanSKU:22177 -Out of stock
Tyrothricin is a polypeptide antibiotic mixture produced by B. brevis.{38058,38059} Tyrothricin is a mixture of tyrocidine and gramicidin that has rapid in vitro bactericidal activity against T. microdentium, T. macrodentium, T. vincentii, T. buccalis, T. mucosum, T. vaginalis, T. cruzi, and L. tropica.{38059} Preclinical studies demonstrate that intravenous use of tyrothricin leads to hemolysis-induced lethality (LD50s = 0.4 and 0.3 mg/kg, in dogs and mice, respectively) and damages liver, kidney, and olfactory tissues. Formulations containing tyrothricin are used topically to treat bacterial skin infections.{38058,38059}
Brand:CaymanSKU:22177 -Out of stock
TZ9 is a cell-permeable triazine compound that inhibits the human E2 ubiquitin-conjugating enzyme Rad6B.{26248} TZ9 selectively docks to the Rad6B catalytic site, inhibits Rad6B-induced histone H2A ubiquitination, downregulates intracellular β-catenin, induces G2/M arrest and apoptosis, and inhibits proliferation and migration of metastatic human breast cancer cells (IC50 = 6 µM).{26248}
Brand:CaymanSKU:- TZ9 is a cell-permeable triazine compound that inhibits the human E2 ubiquitin-conjugating enzyme Rad6B.{26248} TZ9 selectively docks to the Rad6B catalytic site, inhibits Rad6B-induced histone H2A ubiquitination, downregulates intracellular β-catenin, induces G2/M arrest and apoptosis, and inhibits proliferation and migration of metastatic human breast cancer cells (IC50 = 6 µM).{26248}
Brand:CaymanSKU:- TZ9 is a cell-permeable triazine compound that inhibits the human E2 ubiquitin-conjugating enzyme Rad6B.{26248} TZ9 selectively docks to the Rad6B catalytic site, inhibits Rad6B-induced histone H2A ubiquitination, downregulates intracellular β-catenin, induces G2/M arrest and apoptosis, and inhibits proliferation and migration of metastatic human breast cancer cells (IC50 = 6 µM).{26248}
Brand:CaymanSKU:-
U-0126 is a MEK inhibitor with IC50 values of 72 nM and 58 nM for MEK1 and MEK2, respectively.{15076} It is noncompetitive with respect adenosine triphosphate (ATP) and its phosphorylation target ERK and it shows little to no inhibition against a number of other kinases including PKC, Ab1, Raf, MEKK, ERK, JNK, MKK-3, MKK-4, MKK-6, Cdk2, and Cdk4. However, U-0126 does phosphorylate and activate AMP-activated protein kinase (AMPK) in a dose-dependent manner (EC50 = 15 µM in HEK293 cells).{42109} It increases the ratios of ADP to ATP and AMP to ATP and increases phosphorylation of the AMPK target acetyl-CoA carboxylase (ACC).
Brand:CaymanSKU:70970 - 1 mgAvailable on backorder
U-0126 is a MEK inhibitor with IC50 values of 72 nM and 58 nM for MEK1 and MEK2, respectively.{15076} It is noncompetitive with respect adenosine triphosphate (ATP) and its phosphorylation target ERK and it shows little to no inhibition against a number of other kinases including PKC, Ab1, Raf, MEKK, ERK, JNK, MKK-3, MKK-4, MKK-6, Cdk2, and Cdk4. However, U-0126 does phosphorylate and activate AMP-activated protein kinase (AMPK) in a dose-dependent manner (EC50 = 15 µM in HEK293 cells).{42109} It increases the ratios of ADP to ATP and AMP to ATP and increases phosphorylation of the AMPK target acetyl-CoA carboxylase (ACC).
Brand:CaymanSKU:70970 - 10 mgAvailable on backorder
U-0126 is a MEK inhibitor with IC50 values of 72 nM and 58 nM for MEK1 and MEK2, respectively.{15076} It is noncompetitive with respect adenosine triphosphate (ATP) and its phosphorylation target ERK and it shows little to no inhibition against a number of other kinases including PKC, Ab1, Raf, MEKK, ERK, JNK, MKK-3, MKK-4, MKK-6, Cdk2, and Cdk4. However, U-0126 does phosphorylate and activate AMP-activated protein kinase (AMPK) in a dose-dependent manner (EC50 = 15 µM in HEK293 cells).{42109} It increases the ratios of ADP to ATP and AMP to ATP and increases phosphorylation of the AMPK target acetyl-CoA carboxylase (ACC).
Brand:CaymanSKU:70970 - 25 mgAvailable on backorder
U-0126 is a MEK inhibitor with IC50 values of 72 nM and 58 nM for MEK1 and MEK2, respectively.{15076} It is noncompetitive with respect adenosine triphosphate (ATP) and its phosphorylation target ERK and it shows little to no inhibition against a number of other kinases including PKC, Ab1, Raf, MEKK, ERK, JNK, MKK-3, MKK-4, MKK-6, Cdk2, and Cdk4. However, U-0126 does phosphorylate and activate AMP-activated protein kinase (AMPK) in a dose-dependent manner (EC50 = 15 µM in HEK293 cells).{42109} It increases the ratios of ADP to ATP and AMP to ATP and increases phosphorylation of the AMPK target acetyl-CoA carboxylase (ACC).
Brand:CaymanSKU:70970 - 5 mgAvailable on backorder
Impaired trafficking of cholesterol to or from the endoplasmic reticulum (ER) has been implicated in many disease states including Neimann-Pick disease type C (NPC), Alzheimers disease and atherosclerosis. U-18666A is a cell permeable drug that inhibits cholesterol trafficking. It inhibits cholesterol transport from late endosomes/lysosomes to the endoplasmic reticulum (ER), but not cholesterol transport to the plasma membrane as demonstrated in many cell types including macrophages, primary cortical neurons and primary fibroblasts.{14577,14579,14578} In macrophages, micromolar concentrations of U-18666A inhibit multiple pathways of cholesterol trafficking from late endosomes, whereas nanomolar concentrations impair cholesterol trafficking to the ER, a response similar to that found in NPC. U-18666A inhibits oxidosqualene cyclase at high (>0.5 mM) concentrations and oral doses (10 mg/kg) induces cataracts in rats.{14577}
Brand:CaymanSKU:10009085 - 10 mgAvailable on backorder
Impaired trafficking of cholesterol to or from the endoplasmic reticulum (ER) has been implicated in many disease states including Neimann-Pick disease type C (NPC), Alzheimers disease and atherosclerosis. U-18666A is a cell permeable drug that inhibits cholesterol trafficking. It inhibits cholesterol transport from late endosomes/lysosomes to the endoplasmic reticulum (ER), but not cholesterol transport to the plasma membrane as demonstrated in many cell types including macrophages, primary cortical neurons and primary fibroblasts.{14577,14579,14578} In macrophages, micromolar concentrations of U-18666A inhibit multiple pathways of cholesterol trafficking from late endosomes, whereas nanomolar concentrations impair cholesterol trafficking to the ER, a response similar to that found in NPC. U-18666A inhibits oxidosqualene cyclase at high (>0.5 mM) concentrations and oral doses (10 mg/kg) induces cataracts in rats.{14577}
Brand:CaymanSKU:10009085 - 25 mgAvailable on backorder
Impaired trafficking of cholesterol to or from the endoplasmic reticulum (ER) has been implicated in many disease states including Neimann-Pick disease type C (NPC), Alzheimers disease and atherosclerosis. U-18666A is a cell permeable drug that inhibits cholesterol trafficking. It inhibits cholesterol transport from late endosomes/lysosomes to the endoplasmic reticulum (ER), but not cholesterol transport to the plasma membrane as demonstrated in many cell types including macrophages, primary cortical neurons and primary fibroblasts.{14577,14579,14578} In macrophages, micromolar concentrations of U-18666A inhibit multiple pathways of cholesterol trafficking from late endosomes, whereas nanomolar concentrations impair cholesterol trafficking to the ER, a response similar to that found in NPC. U-18666A inhibits oxidosqualene cyclase at high (>0.5 mM) concentrations and oral doses (10 mg/kg) induces cataracts in rats.{14577}
Brand:CaymanSKU:10009085 - 5 mgAvailable on backorder
Impaired trafficking of cholesterol to or from the endoplasmic reticulum (ER) has been implicated in many disease states including Neimann-Pick disease type C (NPC), Alzheimers disease and atherosclerosis. U-18666A is a cell permeable drug that inhibits cholesterol trafficking. It inhibits cholesterol transport from late endosomes/lysosomes to the endoplasmic reticulum (ER), but not cholesterol transport to the plasma membrane as demonstrated in many cell types including macrophages, primary cortical neurons and primary fibroblasts.{14577,14579,14578} In macrophages, micromolar concentrations of U-18666A inhibit multiple pathways of cholesterol trafficking from late endosomes, whereas nanomolar concentrations impair cholesterol trafficking to the ER, a response similar to that found in NPC. U-18666A inhibits oxidosqualene cyclase at high (>0.5 mM) concentrations and oral doses (10 mg/kg) induces cataracts in rats.{14577}
Brand:CaymanSKU:10009085 - 50 mgAvailable on backorder
U-44069 is a stable analog of the endoperoxide PGH2 (Item No. 17020) and a TP receptor agonist. It stimulates shape change in human platelets without a measurable increase in [Ca2+] with an EC50 value of 1.8 nM.{485} U-44069 has an EC50 value of 3 µM and 54 nM for platelet aggregation and phosphatidate formation in human platelets, respectively.{713}
Brand:CaymanSKU:-Out of stock
U-44069 is a stable analog of the endoperoxide PGH2 (Item No. 17020) and a TP receptor agonist. It stimulates shape change in human platelets without a measurable increase in [Ca2+] with an EC50 value of 1.8 nM.{485} U-44069 has an EC50 value of 3 µM and 54 nM for platelet aggregation and phosphatidate formation in human platelets, respectively.{713}
Brand:CaymanSKU:-Out of stock
U-44069 is a stable analog of the endoperoxide PGH2 (Item No. 17020) and a TP receptor agonist. It stimulates shape change in human platelets without a measurable increase in [Ca2+] with an EC50 value of 1.8 nM.{485} U-44069 has an EC50 value of 3 µM and 54 nM for platelet aggregation and phosphatidate formation in human platelets, respectively.{713}
Brand:CaymanSKU:-Out of stock