Cayman

Showing 42901–43050 of 45550 results

  • Ribonucleotide reductase, the rate-limiting enzyme for de novo DNA synthesis, is a common target for chemotherapy. Its increased activity in cancer cells is associated with malignant transformation and proliferation.{14245} Trimidox is a specific ribonucleotide reductase inhibitor that reduces levels of dGTP and dCTP in HL-60 cells, inducing apoptosis via activation of caspases without altering the cell cycle distribution.{14245,15318} Trimidox inhibits growth of human promyelocytic leukemia HL-60 cells with an IC50 value of 35 µM.{14245}  

     

    Brand:
    Cayman
    SKU:10011124 - 25 mg

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  • Ribonucleotide reductase, the rate-limiting enzyme for de novo DNA synthesis, is a common target for chemotherapy. Its increased activity in cancer cells is associated with malignant transformation and proliferation.{14245} Trimidox is a specific ribonucleotide reductase inhibitor that reduces levels of dGTP and dCTP in HL-60 cells, inducing apoptosis via activation of caspases without altering the cell cycle distribution.{14245,15318} Trimidox inhibits growth of human promyelocytic leukemia HL-60 cells with an IC50 value of 35 µM.{14245}  

     

    Brand:
    Cayman
    SKU:10011124 - 5 mg

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  • Ribonucleotide reductase, the rate-limiting enzyme for de novo DNA synthesis, is a common target for chemotherapy. Its increased activity in cancer cells is associated with malignant transformation and proliferation.{14245} Trimidox is a specific ribonucleotide reductase inhibitor that reduces levels of dGTP and dCTP in HL-60 cells, inducing apoptosis via activation of caspases without altering the cell cycle distribution.{14245,15318} Trimidox inhibits growth of human promyelocytic leukemia HL-60 cells with an IC50 value of 35 µM.{14245}  

     

    Brand:
    Cayman
    SKU:10011124 - 50 mg

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  • Trimipramine (maleate) is a tricyclic antidepressant compound that antagonizes several types of neurotransmitter receptors. It is a potent antagonist of histamine H1 (Kd = 0.27 nM), serotonin 5-HT2A, and α1-adrenergic (Kd = 24 nM) receptors.{25914} It demonstrates moderate antagonist activity at dopamine D2 (Kd = 180 nM) and muscarinic acetylcholine (Kd = 58 nM) receptors and weak activity at 5-HT2C, D1, α2-adrenergic (Kd = 680 nM) receptors.{25914} Trimipramine (maleate) is a weak to moderate reuptake inhibitor of serotonin (Ki = 149 nM for SERT), and an extremely weak inhibitor of norepinephrine (Ki = 2.5 µM for NET) and dopamine (Ki = 3.8 µM for DAT) reuptake in slices of rat cerebral cortex.{30236,22877}  

     

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  • Trimipramine (maleate) is a tricyclic antidepressant compound that antagonizes several types of neurotransmitter receptors. It is a potent antagonist of histamine H1 (Kd = 0.27 nM), serotonin 5-HT2A, and α1-adrenergic (Kd = 24 nM) receptors.{25914} It demonstrates moderate antagonist activity at dopamine D2 (Kd = 180 nM) and muscarinic acetylcholine (Kd = 58 nM) receptors and weak activity at 5-HT2C, D1, α2-adrenergic (Kd = 680 nM) receptors.{25914} Trimipramine (maleate) is a weak to moderate reuptake inhibitor of serotonin (Ki = 149 nM for SERT), and an extremely weak inhibitor of norepinephrine (Ki = 2.5 µM for NET) and dopamine (Ki = 3.8 µM for DAT) reuptake in slices of rat cerebral cortex.{30236,22877}  

     

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    Cayman
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  • Trinactin is a macrotetrolide antibiotic produced by Streptomyces and an ionophore for monovalent cations, such as sodium, potassium, and ammonium.{32290,32288,37789} It is commonly used to facilitate the movement of monovalent cations through natural and artificial lipid membranes.{32288}  

     

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    Cayman
    SKU:25741 - 1 mg

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  • Trinactin is a macrotetrolide antibiotic produced by Streptomyces and an ionophore for monovalent cations, such as sodium, potassium, and ammonium.{32290,32288,37789} It is commonly used to facilitate the movement of monovalent cations through natural and artificial lipid membranes.{32288}  

     

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    Cayman
    SKU:25741 - 5 mg

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  • Trioxsalen is a derivative of the photoactive probe psoralen (Item No. 11751). Like psoralen, trioxsalen intercalates into DNA and forms DNA single-strand adducts and interstrand crosslinks when activated with ultraviolet light.{31984,31983} It is used to study DNA structure as well as the cellular response to DNA damage. Trioxsalen and other psoralens photosensitize skin cells to ultraviolet light.{31985}  

     

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    SKU:20044 -

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  • Trioxsalen is a derivative of the photoactive probe psoralen (Item No. 11751). Like psoralen, trioxsalen intercalates into DNA and forms DNA single-strand adducts and interstrand crosslinks when activated with ultraviolet light.{31984,31983} It is used to study DNA structure as well as the cellular response to DNA damage. Trioxsalen and other psoralens photosensitize skin cells to ultraviolet light.{31985}  

     

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    Cayman
    SKU:20044 -

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  • Trioxsalen is a derivative of the photoactive probe psoralen (Item No. 11751). Like psoralen, trioxsalen intercalates into DNA and forms DNA single-strand adducts and interstrand crosslinks when activated with ultraviolet light.{31984,31983} It is used to study DNA structure as well as the cellular response to DNA damage. Trioxsalen and other psoralens photosensitize skin cells to ultraviolet light.{31985}  

     

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    Cayman
    SKU:20044 -

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  • Trioxsalen is a derivative of the photoactive probe psoralen (Item No. 11751). Like psoralen, trioxsalen intercalates into DNA and forms DNA single-strand adducts and interstrand crosslinks when activated with ultraviolet light.{31984,31983} It is used to study DNA structure as well as the cellular response to DNA damage. Trioxsalen and other psoralens photosensitize skin cells to ultraviolet light.{31985}  

     

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    Cayman
    SKU:20044 -

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  • Triparanol is a 24-dehydro cholesterol reductase (DHCR24) inhibitor (Ki = 0.523 µM), which is an enzyme involved in the biosynthesis of cholesterol.{34169,34196} It has antitumor properties, such as decreasing proliferation and inducing apoptosis in many cancer cell lines and slowing tumor growth in a mouse xenograft model.{34170} It can also decrease Hedgehog pathway signaling in cancer cells. Formulations containing triparanol were discontinued in the 1960s due to serious adverse side effects, including rapid cataract development.{34171,34172}  

     

    Brand:
    Cayman
    SKU:20918 -

    Out of stock

  • Triparanol is a 24-dehydro cholesterol reductase (DHCR24) inhibitor (Ki = 0.523 µM), which is an enzyme involved in the biosynthesis of cholesterol.{34169,34196} It has antitumor properties, such as decreasing proliferation and inducing apoptosis in many cancer cell lines and slowing tumor growth in a mouse xenograft model.{34170} It can also decrease Hedgehog pathway signaling in cancer cells. Formulations containing triparanol were discontinued in the 1960s due to serious adverse side effects, including rapid cataract development.{34171,34172}  

     

    Brand:
    Cayman
    SKU:20918 -

    Out of stock

  • Triparanol is a 24-dehydro cholesterol reductase (DHCR24) inhibitor (Ki = 0.523 µM), which is an enzyme involved in the biosynthesis of cholesterol.{34169,34196} It has antitumor properties, such as decreasing proliferation and inducing apoptosis in many cancer cell lines and slowing tumor growth in a mouse xenograft model.{34170} It can also decrease Hedgehog pathway signaling in cancer cells. Formulations containing triparanol were discontinued in the 1960s due to serious adverse side effects, including rapid cataract development.{34171,34172}  

     

    Brand:
    Cayman
    SKU:20918 -

    Out of stock

  • Triparanol is a 24-dehydro cholesterol reductase (DHCR24) inhibitor (Ki = 0.523 µM), which is an enzyme involved in the biosynthesis of cholesterol.{34169,34196} It has antitumor properties, such as decreasing proliferation and inducing apoptosis in many cancer cell lines and slowing tumor growth in a mouse xenograft model.{34170} It can also decrease Hedgehog pathway signaling in cancer cells. Formulations containing triparanol were discontinued in the 1960s due to serious adverse side effects, including rapid cataract development.{34171,34172}  

     

    Brand:
    Cayman
    SKU:20918 -

    Out of stock

  • Triphenylphosphine oxide (TPPO) is a coordinating solvent used to activate crystallization of chemical compounds. It has been used in flame retardant applications, as an epoxy cure catalyst, and more recently, to produce nanostructures.  

     

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    Cayman
    SKU:9000289 - 1 g

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  • Triphenylphosphine oxide (TPPO) is a coordinating solvent used to activate crystallization of chemical compounds. It has been used in flame retardant applications, as an epoxy cure catalyst, and more recently, to produce nanostructures.  

     

    Brand:
    Cayman
    SKU:9000289 - 25 mg

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  • Triphenylphosphine oxide (TPPO) is a coordinating solvent used to activate crystallization of chemical compounds. It has been used in flame retardant applications, as an epoxy cure catalyst, and more recently, to produce nanostructures.  

     

    Brand:
    Cayman
    SKU:9000289 - 50 mg

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  • Triphenylphosphine oxide (TPPO) is a coordinating solvent used to activate crystallization of chemical compounds. It has been used in flame retardant applications, as an epoxy cure catalyst, and more recently, to produce nanostructures.  

     

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    Cayman
    SKU:9000289 - 500 mg

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  • Triptolide is the major bioactive constituent of T. wilfordii Hook F., also known as thunder god vine, a traditional Chinese medicinal herb with known antiproliferative, immunosuppressive, anti-inflammatory, antifertility, and anti-polycystic kidney disease effects. Triptolide binds to and inhibits human dCTP pyrophosphatase 1, a “gatekeeper” enzyme that prevents deleterious halogenated nucleotides from entering DNA synthesis, with a Ki value of 168 μM and an IC50 value of 7-10 nM.{22058} Triptolide has also been shown to inhibit LPS-stimulated induction of cyclooxygenase 2 mRNA and synthesis of prostaglandin E2 in human peripheral blood monocytes, rheumatoid arthritis synovial fibroblasts, and human neonatal foreskin fibroblasts with an IC50 value of 0.04 μM.{22057}  

     

    Brand:
    Cayman
    SKU:11973 - 1 mg

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  • Triptolide is the major bioactive constituent of T. wilfordii Hook F., also known as thunder god vine, a traditional Chinese medicinal herb with known antiproliferative, immunosuppressive, anti-inflammatory, antifertility, and anti-polycystic kidney disease effects. Triptolide binds to and inhibits human dCTP pyrophosphatase 1, a “gatekeeper” enzyme that prevents deleterious halogenated nucleotides from entering DNA synthesis, with a Ki value of 168 μM and an IC50 value of 7-10 nM.{22058} Triptolide has also been shown to inhibit LPS-stimulated induction of cyclooxygenase 2 mRNA and synthesis of prostaglandin E2 in human peripheral blood monocytes, rheumatoid arthritis synovial fibroblasts, and human neonatal foreskin fibroblasts with an IC50 value of 0.04 μM.{22057}  

     

    Brand:
    Cayman
    SKU:11973 - 10 mg

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  • Triptolide is the major bioactive constituent of T. wilfordii Hook F., also known as thunder god vine, a traditional Chinese medicinal herb with known antiproliferative, immunosuppressive, anti-inflammatory, antifertility, and anti-polycystic kidney disease effects. Triptolide binds to and inhibits human dCTP pyrophosphatase 1, a “gatekeeper” enzyme that prevents deleterious halogenated nucleotides from entering DNA synthesis, with a Ki value of 168 μM and an IC50 value of 7-10 nM.{22058} Triptolide has also been shown to inhibit LPS-stimulated induction of cyclooxygenase 2 mRNA and synthesis of prostaglandin E2 in human peripheral blood monocytes, rheumatoid arthritis synovial fibroblasts, and human neonatal foreskin fibroblasts with an IC50 value of 0.04 μM.{22057}  

     

    Brand:
    Cayman
    SKU:11973 - 5 mg

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  • Triptorelin is a synthetic gonadotropin-releasing hormone (GnRH) peptide agonist that binds to the GnRH receptor (GnRHR; Ki = 0.3 nM in CHO cells expressing the human receptor).{36464} It inhibits the growth of DU145, LNCaP, and PC3 prostate and OVCAR-3 ovarian cancer cells (IC50s = 62.1, 73.4, 98.1, and 67.7 μM, respectively).{52097} Triptorelin also inhibits the growth of the triple-negative breast cancer (TNBC) cell lines HCC1806 and MDA-MB-231 (EC50s = 58.29 and 31.59 μM, respectively).{52096} It stimulates follicle stimulating hormone (FSH) and luteinizing hormone (LH) release from primary rat pituitary cells when used at a concentration of 50 nM.{52097} It also decreases tumor volume of Dunning R3327H prostate tumor flank implants and reduces prostate and testis weight in rats when administered at a dose of 1 mg/kg per day.{39555} Formulations containing triptorelin have been used in the palliative treatment of advanced prostate cancer.  

     

    Brand:
    Cayman
    SKU:28613 - 10 mg

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  • Triptorelin is a synthetic gonadotropin-releasing hormone (GnRH) peptide agonist that binds to the GnRH receptor (GnRHR; Ki = 0.3 nM in CHO cells expressing the human receptor).{36464} It inhibits the growth of DU145, LNCaP, and PC3 prostate and OVCAR-3 ovarian cancer cells (IC50s = 62.1, 73.4, 98.1, and 67.7 μM, respectively).{52097} Triptorelin also inhibits the growth of the triple-negative breast cancer (TNBC) cell lines HCC1806 and MDA-MB-231 (EC50s = 58.29 and 31.59 μM, respectively).{52096} It stimulates follicle stimulating hormone (FSH) and luteinizing hormone (LH) release from primary rat pituitary cells when used at a concentration of 50 nM.{52097} It also decreases tumor volume of Dunning R3327H prostate tumor flank implants and reduces prostate and testis weight in rats when administered at a dose of 1 mg/kg per day.{39555} Formulations containing triptorelin have been used in the palliative treatment of advanced prostate cancer.  

     

    Brand:
    Cayman
    SKU:28613 - 25 mg

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  • Triptorelin is a synthetic gonadotropin-releasing hormone (GnRH) peptide agonist that binds to the GnRH receptor (GnRHR; Ki = 0.3 nM in CHO cells expressing the human receptor).{36464} It inhibits the growth of DU145, LNCaP, and PC3 prostate and OVCAR-3 ovarian cancer cells (IC50s = 62.1, 73.4, 98.1, and 67.7 μM, respectively).{52097} Triptorelin also inhibits the growth of the triple-negative breast cancer (TNBC) cell lines HCC1806 and MDA-MB-231 (EC50s = 58.29 and 31.59 μM, respectively).{52096} It stimulates follicle stimulating hormone (FSH) and luteinizing hormone (LH) release from primary rat pituitary cells when used at a concentration of 50 nM.{52097} It also decreases tumor volume of Dunning R3327H prostate tumor flank implants and reduces prostate and testis weight in rats when administered at a dose of 1 mg/kg per day.{39555} Formulations containing triptorelin have been used in the palliative treatment of advanced prostate cancer.  

     

    Brand:
    Cayman
    SKU:28613 - 5 mg

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  • Brand:
    Cayman
    SKU:700751 - 5 ml

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  • Tris(4,7-diphenyl-1,10-phenanthroline)ruthenium II dichloride complex is a luminescent probe (absorption λmax: 455 nm, luminescence λmax: 613 nm) widely used for detection and quantitation of oxygen.{26592} The dye is strongly reduced by molecular oxygen as a result of dynamic quenching; thus oxygen detection can be based on either measurement of intensity or decay time.{26591} This oxygen probe has been used to optimize optical oxygen sensors, to measure oxygen flux through tissues and in skin tumors, and for oxygen imaging.{26592,26594,26604,26590,26593}  

     

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  • Tris(4,7-diphenyl-1,10-phenanthroline)ruthenium II dichloride complex is a luminescent probe (absorption λmax: 455 nm, luminescence λmax: 613 nm) widely used for detection and quantitation of oxygen.{26592} The dye is strongly reduced by molecular oxygen as a result of dynamic quenching; thus oxygen detection can be based on either measurement of intensity or decay time.{26591} This oxygen probe has been used to optimize optical oxygen sensors, to measure oxygen flux through tissues and in skin tumors, and for oxygen imaging.{26592,26594,26604,26590,26593}  

     

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    Cayman
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  • Tris(4,7-diphenyl-1,10-phenanthroline)ruthenium II dichloride complex is a luminescent probe (absorption λmax: 455 nm, luminescence λmax: 613 nm) widely used for detection and quantitation of oxygen.{26592} The dye is strongly reduced by molecular oxygen as a result of dynamic quenching; thus oxygen detection can be based on either measurement of intensity or decay time.{26591} This oxygen probe has been used to optimize optical oxygen sensors, to measure oxygen flux through tissues and in skin tumors, and for oxygen imaging.{26592,26594,26604,26590,26593}  

     

    Brand:
    Cayman
    SKU:-
  • Tris(4,7-diphenyl-1,10-phenanthroline)ruthenium II dichloride complex is a luminescent probe (absorption λmax: 455 nm, luminescence λmax: 613 nm) widely used for detection and quantitation of oxygen.{26592} The dye is strongly reduced by molecular oxygen as a result of dynamic quenching; thus oxygen detection can be based on either measurement of intensity or decay time.{26591} This oxygen probe has been used to optimize optical oxygen sensors, to measure oxygen flux through tissues and in skin tumors, and for oxygen imaging.{26592,26594,26604,26590,26593}  

     

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    Cayman
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  • Triticonazole is a triazole fungicide used for the control of common soil and seed-borne diseases on cereals and other crops.{30331} The antifungal effects of triticonazole are due to its ability to inhibit ergosterol biosynthesis.{30331}  

     

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  • TRO 19622 is an orally bioavailable mitochondrial-targeted neuroprotective agent that binds to and inhibits opening of the mitochondrial permeability transition pore (mPTP).{39891,39892} It prevents mPTP opening induced by arachidonic acid (Item No. 90010) in HeLa cells when used at a concentration of 10 µM.{39891} TRO 19622 promotes survival of motor neurons in vitro in a concentration-dependent manner in the absence of neurotrophic factors (EC50 = 3.2 µM) and in vivo in a neonatal rat model of facial nerve axotomy when administered at a dose of 100 mg/kg per day.{39892} It delays onset of motor deficits and extends survival in the SOD1G93A transgenic model of amyotrophic lateral sclerosis (ALS). TRO 19622 (30 and 100 mg/kg) also increases the latency to paw withdrawal in a mechanical hyperalgesia test in rat models of streptozotocin-induced diabetic and vincristine-induced neuropathic pain but not in models of acute, inflammatory, or injury-induced pain.{39893}  

     

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    Cayman
    SKU:21264 -

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  • TRO 19622 is an orally bioavailable mitochondrial-targeted neuroprotective agent that binds to and inhibits opening of the mitochondrial permeability transition pore (mPTP).{39891,39892} It prevents mPTP opening induced by arachidonic acid (Item No. 90010) in HeLa cells when used at a concentration of 10 µM.{39891} TRO 19622 promotes survival of motor neurons in vitro in a concentration-dependent manner in the absence of neurotrophic factors (EC50 = 3.2 µM) and in vivo in a neonatal rat model of facial nerve axotomy when administered at a dose of 100 mg/kg per day.{39892} It delays onset of motor deficits and extends survival in the SOD1G93A transgenic model of amyotrophic lateral sclerosis (ALS). TRO 19622 (30 and 100 mg/kg) also increases the latency to paw withdrawal in a mechanical hyperalgesia test in rat models of streptozotocin-induced diabetic and vincristine-induced neuropathic pain but not in models of acute, inflammatory, or injury-induced pain.{39893}  

     

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    Cayman
    SKU:21264 -

    Out of stock

  • TRO 19622 is an orally bioavailable mitochondrial-targeted neuroprotective agent that binds to and inhibits opening of the mitochondrial permeability transition pore (mPTP).{39891,39892} It prevents mPTP opening induced by arachidonic acid (Item No. 90010) in HeLa cells when used at a concentration of 10 µM.{39891} TRO 19622 promotes survival of motor neurons in vitro in a concentration-dependent manner in the absence of neurotrophic factors (EC50 = 3.2 µM) and in vivo in a neonatal rat model of facial nerve axotomy when administered at a dose of 100 mg/kg per day.{39892} It delays onset of motor deficits and extends survival in the SOD1G93A transgenic model of amyotrophic lateral sclerosis (ALS). TRO 19622 (30 and 100 mg/kg) also increases the latency to paw withdrawal in a mechanical hyperalgesia test in rat models of streptozotocin-induced diabetic and vincristine-induced neuropathic pain but not in models of acute, inflammatory, or injury-induced pain.{39893}  

     

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    Cayman
    SKU:21264 -

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  • Trofosfamide is a nitrogen mustard alkylating agent and a derivative of cyclophosphamide (Item No. 13849) that has antiproliferative activities.{52010,52011} It increases the number of micronucleated polychromatic red blood cells isolated from mouse bone marrow, indicating cytogenetic activity, when administered at doses of 40, 80, and 160 mg/kg.{52009} Trofosfamide (100 mg/kg) inhibits proliferation of isolated splenocytes in the allogenic mixed lymphocyte reaction.{52010} It reduces sheep red blood cell-induced increases in the number of antibody-producing spleen cells isolated from rats when administered at a dose of 40 mg/kg.{52011}  

     

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    Cayman
    SKU:21874 -

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  • Trofosfamide is a nitrogen mustard alkylating agent and a derivative of cyclophosphamide (Item No. 13849) that has antiproliferative activities.{52010,52011} It increases the number of micronucleated polychromatic red blood cells isolated from mouse bone marrow, indicating cytogenetic activity, when administered at doses of 40, 80, and 160 mg/kg.{52009} Trofosfamide (100 mg/kg) inhibits proliferation of isolated splenocytes in the allogenic mixed lymphocyte reaction.{52010} It reduces sheep red blood cell-induced increases in the number of antibody-producing spleen cells isolated from rats when administered at a dose of 40 mg/kg.{52011}  

     

    Brand:
    Cayman
    SKU:21874 -

    Out of stock

  • Trofosfamide is a nitrogen mustard alkylating agent and a derivative of cyclophosphamide (Item No. 13849) that has antiproliferative activities.{52010,52011} It increases the number of micronucleated polychromatic red blood cells isolated from mouse bone marrow, indicating cytogenetic activity, when administered at doses of 40, 80, and 160 mg/kg.{52009} Trofosfamide (100 mg/kg) inhibits proliferation of isolated splenocytes in the allogenic mixed lymphocyte reaction.{52010} It reduces sheep red blood cell-induced increases in the number of antibody-producing spleen cells isolated from rats when administered at a dose of 40 mg/kg.{52011}  

     

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    Cayman
    SKU:21874 -

    Out of stock

  • Trofosfamide is a nitrogen mustard alkylating agent and a derivative of cyclophosphamide (Item No. 13849) that has antiproliferative activities.{52010,52011} It increases the number of micronucleated polychromatic red blood cells isolated from mouse bone marrow, indicating cytogenetic activity, when administered at doses of 40, 80, and 160 mg/kg.{52009} Trofosfamide (100 mg/kg) inhibits proliferation of isolated splenocytes in the allogenic mixed lymphocyte reaction.{52010} It reduces sheep red blood cell-induced increases in the number of antibody-producing spleen cells isolated from rats when administered at a dose of 40 mg/kg.{52011}  

     

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    Cayman
    SKU:21874 -

    Out of stock

  • Troglitazone is a selective agonist of peroxisome proliferator-activated receptor γ (PPARγ; EC50s = 0.78 and 0.55 μM for the mouse and human receptors, respectively, in a transactivation assay).{10670} It is selective for PPARγ over PPARα and PPARδ, at which it is inactive at concentrations up to 10 μM. Troglitazone (500 mg/kg twice per day) exhibits antihyperglycemic and antihyperlipidemic properties in Zucker diabetic fatty rats, reducing plasma glucose and triglyceride levels by 61 and 87% respectively.{25251} It also induces cell cycle arrest at the G1 phase in SK-HEP-1 and Hep3B hepatocellular carcinoma cells when used at a concentration of 10 μM and increases apoptosis in these cells at concentrations of 30 μM and higher.{10669}  

     

    Brand:
    Cayman
    SKU:71750 - 10 mg

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  • Troglitazone is a selective agonist of peroxisome proliferator-activated receptor γ (PPARγ; EC50s = 0.78 and 0.55 μM for the mouse and human receptors, respectively, in a transactivation assay).{10670} It is selective for PPARγ over PPARα and PPARδ, at which it is inactive at concentrations up to 10 μM. Troglitazone (500 mg/kg twice per day) exhibits antihyperglycemic and antihyperlipidemic properties in Zucker diabetic fatty rats, reducing plasma glucose and triglyceride levels by 61 and 87% respectively.{25251} It also induces cell cycle arrest at the G1 phase in SK-HEP-1 and Hep3B hepatocellular carcinoma cells when used at a concentration of 10 μM and increases apoptosis in these cells at concentrations of 30 μM and higher.{10669}  

     

    Brand:
    Cayman
    SKU:71750 - 100 mg

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  • Troglitazone is a selective agonist of peroxisome proliferator-activated receptor γ (PPARγ; EC50s = 0.78 and 0.55 μM for the mouse and human receptors, respectively, in a transactivation assay).{10670} It is selective for PPARγ over PPARα and PPARδ, at which it is inactive at concentrations up to 10 μM. Troglitazone (500 mg/kg twice per day) exhibits antihyperglycemic and antihyperlipidemic properties in Zucker diabetic fatty rats, reducing plasma glucose and triglyceride levels by 61 and 87% respectively.{25251} It also induces cell cycle arrest at the G1 phase in SK-HEP-1 and Hep3B hepatocellular carcinoma cells when used at a concentration of 10 μM and increases apoptosis in these cells at concentrations of 30 μM and higher.{10669}  

     

    Brand:
    Cayman
    SKU:71750 - 5 mg

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  • Troglitazone is a selective agonist of peroxisome proliferator-activated receptor γ (PPARγ; EC50s = 0.78 and 0.55 μM for the mouse and human receptors, respectively, in a transactivation assay).{10670} It is selective for PPARγ over PPARα and PPARδ, at which it is inactive at concentrations up to 10 μM. Troglitazone (500 mg/kg twice per day) exhibits antihyperglycemic and antihyperlipidemic properties in Zucker diabetic fatty rats, reducing plasma glucose and triglyceride levels by 61 and 87% respectively.{25251} It also induces cell cycle arrest at the G1 phase in SK-HEP-1 and Hep3B hepatocellular carcinoma cells when used at a concentration of 10 μM and increases apoptosis in these cells at concentrations of 30 μM and higher.{10669}  

     

    Brand:
    Cayman
    SKU:71750 - 50 mg

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  • Trolox is a cell-permeable, water-soluble derivative of vitamin E with potent antioxidant properties. It is commonly used as a standard or positive control in antioxidant assays.{12069,13782} In addition, trolox is used to assess the role of oxidative injury in processes like neuronal cell death and aging.{16492,16490} Trolox is effective as adjunctive therapy in the treatment of certain cancers.{16491}  

     

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    Cayman
    SKU:10011659 - 1 g

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  • Trolox is a cell-permeable, water-soluble derivative of vitamin E with potent antioxidant properties. It is commonly used as a standard or positive control in antioxidant assays.{12069,13782} In addition, trolox is used to assess the role of oxidative injury in processes like neuronal cell death and aging.{16492,16490} Trolox is effective as adjunctive therapy in the treatment of certain cancers.{16491}  

     

    Brand:
    Cayman
    SKU:10011659 - 250 mg

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  • Trolox is a cell-permeable, water-soluble derivative of vitamin E with potent antioxidant properties. It is commonly used as a standard or positive control in antioxidant assays.{12069,13782} In addition, trolox is used to assess the role of oxidative injury in processes like neuronal cell death and aging.{16492,16490} Trolox is effective as adjunctive therapy in the treatment of certain cancers.{16491}  

     

    Brand:
    Cayman
    SKU:10011659 - 500 mg

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  • Muscarinic receptors are G protein-coupled acetylcholine receptors that play diverse roles. Five subtypes (M1-5) have been identified, which preferentially couple to various effector systems based on their G protein interaction.{27107,27108}Tropicamide is a muscarinic acetylcholine receptor (mAChR) antagonist (pKi = 7.2 in chicken heart) that displays 3-fold selectivity for M4.{27107,27106,27105} When applied as eye drops, it produces temporary mydriasis (pupil dilation; EC50 = 6 µg/ml) and cycloplegia (ciliary muscle paralysis; EC50 = 25 µg/ml).{27109} Tropicamide has been used to probe mAChR activity in a mouse model of fragile X syndrome.{27110}  

     

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    Cayman
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  • Muscarinic receptors are G protein-coupled acetylcholine receptors that play diverse roles. Five subtypes (M1-5) have been identified, which preferentially couple to various effector systems based on their G protein interaction.{27107,27108}Tropicamide is a muscarinic acetylcholine receptor (mAChR) antagonist (pKi = 7.2 in chicken heart) that displays 3-fold selectivity for M4.{27107,27106,27105} When applied as eye drops, it produces temporary mydriasis (pupil dilation; EC50 = 6 µg/ml) and cycloplegia (ciliary muscle paralysis; EC50 = 25 µg/ml).{27109} Tropicamide has been used to probe mAChR activity in a mouse model of fragile X syndrome.{27110}  

     

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    Cayman
    SKU:-

    Out of stock

  • Tropifexor is an agonist of farnesoid X receptors (FXR).{48126} It enhances the interaction between the human FXR ligand binding domain and the steroid receptor coactivator 1 (SRC-1) peptide in a homogeneous time-resolved fluorescence (HTRF) coactivator interaction assay (EC50 = 0.2 nM). It increases expression of the FXR target genes BSEP and SHP and decreases expression of CPY8B1 in rat liver in a dose-dependent manner, as well as increases expression of SHP and FGF15 in rat ileum. Tropifexor (0.3 mg/kg) reduces triglyceride levels by 79% in rat serum. It reduces fibrosis, inflammation, and steatosis in a mouse model of nonalcoholic steatohepatitis (NASH).{48127}  

     

    Brand:
    Cayman
    SKU:25748 - 1 mg

    Available on backorder

  • Tropifexor is an agonist of farnesoid X receptors (FXR).{48126} It enhances the interaction between the human FXR ligand binding domain and the steroid receptor coactivator 1 (SRC-1) peptide in a homogeneous time-resolved fluorescence (HTRF) coactivator interaction assay (EC50 = 0.2 nM). It increases expression of the FXR target genes BSEP and SHP and decreases expression of CPY8B1 in rat liver in a dose-dependent manner, as well as increases expression of SHP and FGF15 in rat ileum. Tropifexor (0.3 mg/kg) reduces triglyceride levels by 79% in rat serum. It reduces fibrosis, inflammation, and steatosis in a mouse model of nonalcoholic steatohepatitis (NASH).{48127}  

     

    Brand:
    Cayman
    SKU:25748 - 10 mg

    Available on backorder

  • Tropifexor is an agonist of farnesoid X receptors (FXR).{48126} It enhances the interaction between the human FXR ligand binding domain and the steroid receptor coactivator 1 (SRC-1) peptide in a homogeneous time-resolved fluorescence (HTRF) coactivator interaction assay (EC50 = 0.2 nM). It increases expression of the FXR target genes BSEP and SHP and decreases expression of CPY8B1 in rat liver in a dose-dependent manner, as well as increases expression of SHP and FGF15 in rat ileum. Tropifexor (0.3 mg/kg) reduces triglyceride levels by 79% in rat serum. It reduces fibrosis, inflammation, and steatosis in a mouse model of nonalcoholic steatohepatitis (NASH).{48127}  

     

    Brand:
    Cayman
    SKU:25748 - 5 mg

    Available on backorder

  • Tropifexor is an agonist of farnesoid X receptors (FXR).{48126} It enhances the interaction between the human FXR ligand binding domain and the steroid receptor coactivator 1 (SRC-1) peptide in a homogeneous time-resolved fluorescence (HTRF) coactivator interaction assay (EC50 = 0.2 nM). It increases expression of the FXR target genes BSEP and SHP and decreases expression of CPY8B1 in rat liver in a dose-dependent manner, as well as increases expression of SHP and FGF15 in rat ileum. Tropifexor (0.3 mg/kg) reduces triglyceride levels by 79% in rat serum. It reduces fibrosis, inflammation, and steatosis in a mouse model of nonalcoholic steatohepatitis (NASH).{48127}  

     

    Brand:
    Cayman
    SKU:25748 - 500 µg

    Available on backorder

  • Tropine is a naturally-occurring tropane alkaloid extracted primarily from plants of the Solanaceae family.{22119} It serves as an intermediate in the synthesis of a variety of bioactive alkaloids, including atropine (Item No. 12008), benztropine (Item No. 18214), and scopolamine, many of which have potent neurological actions.{22119,30247}  

     

    Brand:
    Cayman
    SKU:-

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  • Tropine is a naturally-occurring tropane alkaloid extracted primarily from plants of the Solanaceae family.{22119} It serves as an intermediate in the synthesis of a variety of bioactive alkaloids, including atropine (Item No. 12008), benztropine (Item No. 18214), and scopolamine, many of which have potent neurological actions.{22119,30247}  

     

    Brand:
    Cayman
    SKU:-

    Available on backorder

  • Tropine is a naturally-occurring tropane alkaloid extracted primarily from plants of the Solanaceae family.{22119} It serves as an intermediate in the synthesis of a variety of bioactive alkaloids, including atropine (Item No. 12008), benztropine (Item No. 18214), and scopolamine, many of which have potent neurological actions.{22119,30247}  

     

    Brand:
    Cayman
    SKU:-

    Available on backorder

  • Tropine is a naturally-occurring tropane alkaloid extracted primarily from plants of the Solanaceae family.{22119} It serves as an intermediate in the synthesis of a variety of bioactive alkaloids, including atropine (Item No. 12008), benztropine (Item No. 18214), and scopolamine, many of which have potent neurological actions.{22119,30247}  

     

    Brand:
    Cayman
    SKU:-

    Available on backorder

  • Tropisetron is an orally-bioavailable antagonist of the serotonin (5-HT) receptor 5-HT3 (Ki = 5.3 nM).{33369,33371} Antagonists of 5-HT3, including tropisetron, have been shown to prevent nausea and emesis in patients undergoing chemotherapy in clinical trials.{33373,33374} Tropisetron is also an antagonist of the α9 nicotinic acetylcholine receptor (nAChR; IC50 = 166 nM) and a partial agonist of α7 nAChR (Ki = 6.9 nM).{33372,33370}  

     

    Brand:
    Cayman
    SKU:21240 -

    Out of stock

  • Tropisetron is an orally-bioavailable antagonist of the serotonin (5-HT) receptor 5-HT3 (Ki = 5.3 nM).{33369,33371} Antagonists of 5-HT3, including tropisetron, have been shown to prevent nausea and emesis in patients undergoing chemotherapy in clinical trials.{33373,33374} Tropisetron is also an antagonist of the α9 nicotinic acetylcholine receptor (nAChR; IC50 = 166 nM) and a partial agonist of α7 nAChR (Ki = 6.9 nM).{33372,33370}  

     

    Brand:
    Cayman
    SKU:21240 -

    Out of stock

  • Tropisetron is an orally-bioavailable antagonist of the serotonin (5-HT) receptor 5-HT3 (Ki = 5.3 nM).{33369,33371} Antagonists of 5-HT3, including tropisetron, have been shown to prevent nausea and emesis in patients undergoing chemotherapy in clinical trials.{33373,33374} Tropisetron is also an antagonist of the α9 nicotinic acetylcholine receptor (nAChR; IC50 = 166 nM) and a partial agonist of α7 nAChR (Ki = 6.9 nM).{33372,33370}  

     

    Brand:
    Cayman
    SKU:21240 -

    Out of stock

  • Tropisetron is an orally-bioavailable antagonist of the serotonin (5-HT) receptor 5-HT3 (Ki = 5.3 nM).{33369,33371} Antagonists of 5-HT3, including tropisetron, have been shown to prevent nausea and emesis in patients undergoing chemotherapy in clinical trials.{33373,33374} Tropisetron is also an antagonist of the α9 nicotinic acetylcholine receptor (nAChR; IC50 = 166 nM) and a partial agonist of α7 nAChR (Ki = 6.9 nM).{33372,33370}  

     

    Brand:
    Cayman
    SKU:21240 -

    Out of stock

  • Tropodithietic acid (TDA) is a broad-spectrum antibiotic produced by the marine bacterium R. gallaeciensis.{38281} It is active against a variety of Gram-negative α-proteobacteria, γ-proteobacteria, and flavobacteria as well as Gram-positive actinobacteria strains in a disc assay. TDA also inhibits the growth of S. aureus and V. anguillarum with MIC values of 39 and 19 μM, respectively.{38282}  

     

    Brand:
    Cayman
    SKU:23244 - 1 mg

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  • Tropolone is a terpene that has been found in cupressaceous tree bark and has diverse biological activities.{52319,52320,52321,52322,52323} It inhibits catechol O-methyltransferase (COMT; Ki = 22 µM).{52319} Tropolone is bacteriostatic against a panel of Gram-positive and Gram-negative bacteria (MICs = 12-82 µM) and bactericidal against A. hydrophilia and C. violaceum when used at a concentration of 20 mM.{52320} It is an iron chelator that inhibits iron-dependent growth of the wood rot fungus P. placenta when used at a concentration of 50 µM and P. placenta degradation of pine sapwood blocks impregnated with 5 mM tropolone.{52321} It inhibits LPS-induced production of nitric oxide (NO) in RAW 264.7 cells (IC50 = 12 µM).{52322} Tropolone (0.25 mmol/animal) reduces thyroid radioiodide uptake in rats.{52323} Dietary administration of tropolone induces growth retardation and hyperactivity in mice.  

     

    Brand:
    Cayman
    SKU:29674 - 1 mg

    Available on backorder

  • Tropolone is a terpene that has been found in cupressaceous tree bark and has diverse biological activities.{52319,52320,52321,52322,52323} It inhibits catechol O-methyltransferase (COMT; Ki = 22 µM).{52319} Tropolone is bacteriostatic against a panel of Gram-positive and Gram-negative bacteria (MICs = 12-82 µM) and bactericidal against A. hydrophilia and C. violaceum when used at a concentration of 20 mM.{52320} It is an iron chelator that inhibits iron-dependent growth of the wood rot fungus P. placenta when used at a concentration of 50 µM and P. placenta degradation of pine sapwood blocks impregnated with 5 mM tropolone.{52321} It inhibits LPS-induced production of nitric oxide (NO) in RAW 264.7 cells (IC50 = 12 µM).{52322} Tropolone (0.25 mmol/animal) reduces thyroid radioiodide uptake in rats.{52323} Dietary administration of tropolone induces growth retardation and hyperactivity in mice.  

     

    Brand:
    Cayman
    SKU:29674 - 10 mg

    Available on backorder

  • Tropolone is a terpene that has been found in cupressaceous tree bark and has diverse biological activities.{52319,52320,52321,52322,52323} It inhibits catechol O-methyltransferase (COMT; Ki = 22 µM).{52319} Tropolone is bacteriostatic against a panel of Gram-positive and Gram-negative bacteria (MICs = 12-82 µM) and bactericidal against A. hydrophilia and C. violaceum when used at a concentration of 20 mM.{52320} It is an iron chelator that inhibits iron-dependent growth of the wood rot fungus P. placenta when used at a concentration of 50 µM and P. placenta degradation of pine sapwood blocks impregnated with 5 mM tropolone.{52321} It inhibits LPS-induced production of nitric oxide (NO) in RAW 264.7 cells (IC50 = 12 µM).{52322} Tropolone (0.25 mmol/animal) reduces thyroid radioiodide uptake in rats.{52323} Dietary administration of tropolone induces growth retardation and hyperactivity in mice.  

     

    Brand:
    Cayman
    SKU:29674 - 25 mg

    Available on backorder

  • Tropolone is a terpene that has been found in cupressaceous tree bark and has diverse biological activities.{52319,52320,52321,52322,52323} It inhibits catechol O-methyltransferase (COMT; Ki = 22 µM).{52319} Tropolone is bacteriostatic against a panel of Gram-positive and Gram-negative bacteria (MICs = 12-82 µM) and bactericidal against A. hydrophilia and C. violaceum when used at a concentration of 20 mM.{52320} It is an iron chelator that inhibits iron-dependent growth of the wood rot fungus P. placenta when used at a concentration of 50 µM and P. placenta degradation of pine sapwood blocks impregnated with 5 mM tropolone.{52321} It inhibits LPS-induced production of nitric oxide (NO) in RAW 264.7 cells (IC50 = 12 µM).{52322} Tropolone (0.25 mmol/animal) reduces thyroid radioiodide uptake in rats.{52323} Dietary administration of tropolone induces growth retardation and hyperactivity in mice.  

     

    Brand:
    Cayman
    SKU:29674 - 5 mg

    Available on backorder

  • Trospium is an antagonist of muscarinic (M) receptors (Kis = 0.50-2.3 nM for human M1-5 recombinant receptors, respectively).{28353} Formulations containing antimuscarinics, including trospium, are used to manage overactive bladder by relieving urgency, frequency, and incontinence.{28353,22773,33470}  

     

    Brand:
    Cayman
    SKU:21279 -

    Out of stock

  • Trospium is an antagonist of muscarinic (M) receptors (Kis = 0.50-2.3 nM for human M1-5 recombinant receptors, respectively).{28353} Formulations containing antimuscarinics, including trospium, are used to manage overactive bladder by relieving urgency, frequency, and incontinence.{28353,22773,33470}  

     

    Brand:
    Cayman
    SKU:21279 -

    Out of stock

  • Trospium is an antagonist of muscarinic (M) receptors (Kis = 0.50-2.3 nM for human M1-5 recombinant receptors, respectively).{28353} Formulations containing antimuscarinics, including trospium, are used to manage overactive bladder by relieving urgency, frequency, and incontinence.{28353,22773,33470}  

     

    Brand:
    Cayman
    SKU:21279 -

    Out of stock

  • Trospium is an antagonist of muscarinic (M) receptors (Kis = 0.50-2.3 nM for human M1-5 recombinant receptors, respectively).{28353} Formulations containing antimuscarinics, including trospium, are used to manage overactive bladder by relieving urgency, frequency, and incontinence.{28353,22773,33470}  

     

    Brand:
    Cayman
    SKU:21279 -

    Out of stock

  • Trovafloxacin is a broad spectrum antibiotic that inhibits the uncoiling of supercoiled DNA in bacteria by blocking the activity of topoisomerase IV (IC50 = 3.02 µg/ml) and DNA gyrase (IC50 = 7.13 µg/ml).{27493}  

     

    Brand:
    Cayman
    SKU:9000303 - 10 mg

    Available on backorder

  • Trovafloxacin is a broad spectrum antibiotic that inhibits the uncoiling of supercoiled DNA in bacteria by blocking the activity of topoisomerase IV (IC50 = 3.02 µg/ml) and DNA gyrase (IC50 = 7.13 µg/ml).{27493}  

     

    Brand:
    Cayman
    SKU:9000303 - 5 mg

    Available on backorder

  • Trovafloxacin is a broad spectrum antibiotic that inhibits the uncoiling of supercoiled DNA in bacteria by blocking the activity of topoisomerase IV (IC50 = 3.02 µg/ml) and DNA gyrase (IC50 = 7.13 µg/ml).{27493}  

     

    Brand:
    Cayman
    SKU:9000303 - 50 mg

    Available on backorder

  • Troxerutin is a flavonoid that has been found in a variety of fruits and vegetables and has diverse biological activities.{48639,48640,48641} It reduces D-galactose-induced increases in renal malondialdehyde (MDA) levels and decreases in renal Cu/Zn superoxide dismutase (SOD), catalase, and glutathione peroxidase (GPX) activities in mice when administered at a dose of 150 mg/kg per day, as well as attenuates D-galactose-induced increases in renal levels of NF-κB p65, inducible nitric oxide synthase (iNOS), COX-2, and prostaglandin E2 receptor 2 (EP2).{48639} Troxerutin (150 mg/kg per day) reduces blood glucose levels, plasma triglyceride levels, heart rate, and blood pressure in a rat model of type 2 diabetes induced by streptozotocin (STZ; Item No. 13104).{48640} Troxerutin (150 mg/kg per day) prevents the loss of dopaminergic neurons in the substantia nigra pars compacta (SNC) and reduces apomorphine-induced contralateral rotations in a rat model of Parkinson’s disease induced by 6-OHDA (Item No. 25330).{48641}  

     

    Brand:
    Cayman
    SKU:27220 - 10 g

    Available on backorder

  • Troxerutin is a flavonoid that has been found in a variety of fruits and vegetables and has diverse biological activities.{48639,48640,48641} It reduces D-galactose-induced increases in renal malondialdehyde (MDA) levels and decreases in renal Cu/Zn superoxide dismutase (SOD), catalase, and glutathione peroxidase (GPX) activities in mice when administered at a dose of 150 mg/kg per day, as well as attenuates D-galactose-induced increases in renal levels of NF-κB p65, inducible nitric oxide synthase (iNOS), COX-2, and prostaglandin E2 receptor 2 (EP2).{48639} Troxerutin (150 mg/kg per day) reduces blood glucose levels, plasma triglyceride levels, heart rate, and blood pressure in a rat model of type 2 diabetes induced by streptozotocin (STZ; Item No. 13104).{48640} Troxerutin (150 mg/kg per day) prevents the loss of dopaminergic neurons in the substantia nigra pars compacta (SNC) and reduces apomorphine-induced contralateral rotations in a rat model of Parkinson’s disease induced by 6-OHDA (Item No. 25330).{48641}  

     

    Brand:
    Cayman
    SKU:27220 - 100 g

    Available on backorder

  • Troxerutin is a flavonoid that has been found in a variety of fruits and vegetables and has diverse biological activities.{48639,48640,48641} It reduces D-galactose-induced increases in renal malondialdehyde (MDA) levels and decreases in renal Cu/Zn superoxide dismutase (SOD), catalase, and glutathione peroxidase (GPX) activities in mice when administered at a dose of 150 mg/kg per day, as well as attenuates D-galactose-induced increases in renal levels of NF-κB p65, inducible nitric oxide synthase (iNOS), COX-2, and prostaglandin E2 receptor 2 (EP2).{48639} Troxerutin (150 mg/kg per day) reduces blood glucose levels, plasma triglyceride levels, heart rate, and blood pressure in a rat model of type 2 diabetes induced by streptozotocin (STZ; Item No. 13104).{48640} Troxerutin (150 mg/kg per day) prevents the loss of dopaminergic neurons in the substantia nigra pars compacta (SNC) and reduces apomorphine-induced contralateral rotations in a rat model of Parkinson’s disease induced by 6-OHDA (Item No. 25330).{48641}  

     

    Brand:
    Cayman
    SKU:27220 - 25 g

    Available on backorder

  • Troxerutin is a flavonoid that has been found in a variety of fruits and vegetables and has diverse biological activities.{48639,48640,48641} It reduces D-galactose-induced increases in renal malondialdehyde (MDA) levels and decreases in renal Cu/Zn superoxide dismutase (SOD), catalase, and glutathione peroxidase (GPX) activities in mice when administered at a dose of 150 mg/kg per day, as well as attenuates D-galactose-induced increases in renal levels of NF-κB p65, inducible nitric oxide synthase (iNOS), COX-2, and prostaglandin E2 receptor 2 (EP2).{48639} Troxerutin (150 mg/kg per day) reduces blood glucose levels, plasma triglyceride levels, heart rate, and blood pressure in a rat model of type 2 diabetes induced by streptozotocin (STZ; Item No. 13104).{48640} Troxerutin (150 mg/kg per day) prevents the loss of dopaminergic neurons in the substantia nigra pars compacta (SNC) and reduces apomorphine-induced contralateral rotations in a rat model of Parkinson’s disease induced by 6-OHDA (Item No. 25330).{48641}  

     

    Brand:
    Cayman
    SKU:27220 - 5 g

    Available on backorder

  • Troxipide is an antiulcerative agent.{53962} It inhibits production of superoxide induced by N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP; Item No. 21495) in, and IL-8-induced migration of, isolated human polymorphonuclear (PMN) neutrophils when used at a concentration of 1 mM.{53963} Troxipide (100 and 200 mg/kg, i.p.) reduces the lesion size of gastric ulcers induced by diclofenac (Item Nos. 70680 | 22983) in rats.{53964}  

     

    Brand:
    Cayman
    SKU:30616 - 1 g

    Available on backorder

  • Troxipide is an antiulcerative agent.{53962} It inhibits production of superoxide induced by N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP; Item No. 21495) in, and IL-8-induced migration of, isolated human polymorphonuclear (PMN) neutrophils when used at a concentration of 1 mM.{53963} Troxipide (100 and 200 mg/kg, i.p.) reduces the lesion size of gastric ulcers induced by diclofenac (Item Nos. 70680 | 22983) in rats.{53964}  

     

    Brand:
    Cayman
    SKU:30616 - 5 g

    Available on backorder

  • Troxipide is an antiulcerative agent.{53962} It inhibits production of superoxide induced by N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP; Item No. 21495) in, and IL-8-induced migration of, isolated human polymorphonuclear (PMN) neutrophils when used at a concentration of 1 mM.{53963} Troxipide (100 and 200 mg/kg, i.p.) reduces the lesion size of gastric ulcers induced by diclofenac (Item Nos. 70680 | 22983) in rats.{53964}  

     

    Brand:
    Cayman
    SKU:30616 - 500 mg

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  • Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient.{17533} They are present in the membranes that surround all biological cells and their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces. There are a few main classifications of gated ion channels. There are voltage-gated ion channels, ligand-gated, other gating systems, and finally those that are classified differently, having more exotic characteristics. The first are voltage-gated ion channels which open and close in response to membrane potential. These are then seperated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels, each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inward-rectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels, and cyclic nucleotide-gated channels. Finally, the other classifications are based on less normal characteristics such as two-pore channels and transient receptor potential channels.{17535} Transient receptor potential cation channel, subfamily C, member 4 (TRPC4), is a human gene encoding a protein of the same name. They are expressed in smooth muscle and endothelial cells where they regulate membrane potential and calcium influx. TRPC4 is activated by G(q)/phospholipase C-coupled receptors, but the underlying mechanism remains elusive.{17697} Studies suggest TRPC4 contributes to axonal regeneration after nerve injury.{17698}  

     

    Brand:
    Cayman
    SKU:13719 - 100 µg

    Available on backorder

  • Antigen: rat TRPC4 amino acids 930-947 • Isotype: IgG2b • Host: mouse, clone S77-15 • Cross Reactivity: (+) human, mouse, and rat TRPC4 • Application(s): ICC, IP, and WB • TRPC4 is expressed in smooth muscle and endothelial cells where it regulates membrane potential and calcium influx. TRPC4 is activated by G(q)/phospholipase C-coupled receptors.  

     

    Brand:
    Cayman
    SKU:13719- 100 µg

    Available on backorder

  • Antigen: rat TRPC4 amino acids 930-947 • Isotype: IgG2b • Host: mouse, clone S77-15 • Cross Reactivity: (+) human, mouse, and rat TRPC4 • Application(s): ICC, IP, and WB • TRPC4 is expressed in smooth muscle and endothelial cells where it regulates membrane potential and calcium influx. TRPC4 is activated by G(q)/phospholipase C-coupled receptors.  

     

    Brand:
    Cayman
    SKU:13719- 100 µg
  • Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient.{17533} They are present in the membranes that surround all biological cells and their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces. There are a few main classifications of gated ion channels. There are voltage-gated ion channels, ligand-gated, other gating systems, and finally those that are classified differently, having more exotic characteristics. The first are voltage-gated ion channels which open and close in response to membrane potential. These are then seperated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels, each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inward-rectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels, and cyclic nucleotide-gated channels. Finally, the other classifications are based on less normal characteristics such as two-pore channels and transient receptor potential channels.{17535} TRPs, mammalian homologs of the Drosophila transient receptor potential (TRP) protein, are ion channels that are thought to mediate capacitative calcium entry into the cell. TRP-PLIK is a protein that is both an ion channel and a kinase. As a channel, it conducts calcium and monovalent calcium. As a kinase, it is capable of phosphorylating itself and other substrates. The kinase activity is necessary for channel function, as shown by its dependence on intracellular ATP and by the kinase mutant.{17703,17704}  

     

    Brand:
    Cayman
    SKU:13720 - 100 µg

    Available on backorder

  • Antigen: fusion protein amino acids 1,817-1,863 of mouse TRPM7 • Isotype: IgG1 • Host: mouse, clone S74-25 • Cross Reactivity: (+) human, mouse, and rat TRPM7 • Application(s): ICC, IP, and WB • TTRP-PLIK is a protein that is both an ion channel and a kinase. As a channel, it conducts calcium and monovalent calcium. As a kinase, it is capable of phosphorylating itself and other substrates. The kinase activity is necessary for channel function.  

     

    Brand:
    Cayman
    SKU:13720- 100 µg

    Available on backorder

  • Antigen: fusion protein amino acids 1,817-1,863 of mouse TRPM7 • Isotype: IgG1 • Host: mouse, clone S74-25 • Cross Reactivity: (+) human, mouse, and rat TRPM7 • Application(s): ICC, IP, and WB • TTRP-PLIK is a protein that is both an ion channel and a kinase. As a channel, it conducts calcium and monovalent calcium. As a kinase, it is capable of phosphorylating itself and other substrates. The kinase activity is necessary for channel function.  

     

    Brand:
    Cayman
    SKU:13720- 100 µg
  • Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient.{17533} They are present in the membranes that surround all biological cells and their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces. There are a few main classifications of gated ion channels. There are voltage-gated ion channels, ligand-gated, other gating systems, and finally those that are classified differently, having more exotic characteristics. The first are voltage-gated ion channels which open and close in response to membrane potential. These are then seperated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels, each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inward-rectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels, and cyclic nucleotide-gated channels. Finally, the other classifications are based on less normal characteristics such as two-pore channels and transient receptor potential channels.{17535} The TRPV3 proteins belongs to a family of nonselective cation channels that function in a variety of processes, including temperature sensation and vasoregulation. The thermosensitive members of this family are expressed in subsets of sensory neurons that terminate in the skin and are activated at distinct physiological temperatures. This channel is activated at temperatures between 22 and 40°C. The gene lies in close proximity to another family member (TRPV1) gene on chromosome 17, and the two encoded proteins are thought to associate with each other to form heteromeric channels.{17705,17706}  

     

    Brand:
    Cayman
    SKU:13721 - 100 µg

    Available on backorder

  • Antigen: amino acids 458-474 of rat TRPV3 • Isotype: IgG2a • Host: mouse, clone S15-4 • Cross Reactivity: (+) human, mouse, and rat TRPV3 • Application(s): ICC, IP, and WB • TRPV3 plays a role in temperature sensation and vasoregulation. It is expressed in a subset of sensory neurons that terminate in the skin and is activated at temperatures between 22 and 40°C. The gene lies in close proximity to the TRPV1 gene on chromosome 17, and the two encoded proteins are thought to associate with each other to form heteromeric channels.  

     

    Brand:
    Cayman
    SKU:13721- 100 µg

    Available on backorder

  • Antigen: amino acids 458-474 of rat TRPV3 • Isotype: IgG2a • Host: mouse, clone S15-4 • Cross Reactivity: (+) human, mouse, and rat TRPV3 • Application(s): ICC, IP, and WB • TRPV3 plays a role in temperature sensation and vasoregulation. It is expressed in a subset of sensory neurons that terminate in the skin and is activated at temperatures between 22 and 40°C. The gene lies in close proximity to the TRPV1 gene on chromosome 17, and the two encoded proteins are thought to associate with each other to form heteromeric channels.  

     

    Brand:
    Cayman
    SKU:13721- 100 µg
  • [Bertin Catalog No. G01042]  

     

    Brand:
    Cayman
    SKU:32864 - 100 µl

    Available on backorder

  • Host: Mouse • Applications: ELISA, WB, IF, IP, chromatin IP  

     

    Brand:
    Cayman
    SKU:32864- 100 µl

    Available on backorder

  • Host: Mouse • Applications: ELISA, WB, IF, IP, chromatin IP  

     

    Brand:
    Cayman
    SKU:32864- 100 µl
  • [Bertin Catalog No. G01043]  

     

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    Cayman
    SKU:32865 - 100 µl

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  • Brand:
    Cayman
    SKU:32865- 100 µl

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  • True blue is a fluorescent neuronal retrograde tracer that labels the nucleus, nucleolus, cell body, proximal dendrites, and axons of neurons.{42612} It displays excitation/emission maxima of 373/404 nm, respectively.{38900}  

     

    Brand:
    Cayman
    SKU:26863 - 5 mg

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  • TRV-130 is a G-protein biased μ-opioid receptor agonist (Ki = 1 nM in HEK293 cell membranes expressing the mouse receptor).{61001} It is selective for the μ-opioid receptor over the nociceptin receptor and δ- and κ-opioid receptors, as well as a panel of 120 additional receptors, channels, and enzymes at 10 μM. TRV-130 inhibits forskolin-induced cAMP accumulation, a marker of G-protein signaling, with an EC50 value of 0.4 nM, but has limited effects on β-arrestin-2 recruitment (EC50s = 12.6 nM). TRV-130 increases the latency to paw withdrawal in the hot plate test in rats with an ED50 value of 0.32 mg/kg, which is 10-fold more potent than morphine. It exhibits reduced increases in blood peak partial pressure of carbon dioxide (pCO2) levels, a marker of respiratory depression, compared with morphine when administered at equianalgesic doses in rats.  

     

    Brand:
    Cayman
    SKU:30624 - 10 mg

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  • TRV-130 is a G-protein biased μ-opioid receptor agonist (Ki = 1 nM in HEK293 cell membranes expressing the mouse receptor).{61001} It is selective for the μ-opioid receptor over the nociceptin receptor and δ- and κ-opioid receptors, as well as a panel of 120 additional receptors, channels, and enzymes at 10 μM. TRV-130 inhibits forskolin-induced cAMP accumulation, a marker of G-protein signaling, with an EC50 value of 0.4 nM, but has limited effects on β-arrestin-2 recruitment (EC50s = 12.6 nM). TRV-130 increases the latency to paw withdrawal in the hot plate test in rats with an ED50 value of 0.32 mg/kg, which is 10-fold more potent than morphine. It exhibits reduced increases in blood peak partial pressure of carbon dioxide (pCO2) levels, a marker of respiratory depression, compared with morphine when administered at equianalgesic doses in rats.  

     

    Brand:
    Cayman
    SKU:30624 - 25 mg

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  • TRV-130 is a G-protein biased μ-opioid receptor agonist (Ki = 1 nM in HEK293 cell membranes expressing the mouse receptor).{61001} It is selective for the μ-opioid receptor over the nociceptin receptor and δ- and κ-opioid receptors, as well as a panel of 120 additional receptors, channels, and enzymes at 10 μM. TRV-130 inhibits forskolin-induced cAMP accumulation, a marker of G-protein signaling, with an EC50 value of 0.4 nM, but has limited effects on β-arrestin-2 recruitment (EC50s = 12.6 nM). TRV-130 increases the latency to paw withdrawal in the hot plate test in rats with an ED50 value of 0.32 mg/kg, which is 10-fold more potent than morphine. It exhibits reduced increases in blood peak partial pressure of carbon dioxide (pCO2) levels, a marker of respiratory depression, compared with morphine when administered at equianalgesic doses in rats.  

     

    Brand:
    Cayman
    SKU:30624 - 5 mg

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  • TRX-818 is an anticancer compound.{53140,53141} It inhibits vasculogenic mimicry network formation in C8161 and SK-MEL-28 melanoma cells when used at concentrations ranging from less than or equal to 5 to 10 nM. {53140} TRX-818 (10 nM) decreases pro-Nodal protein levels and Smad2 phosphorylation in C8161 cells. It reduces tumor volume with a minimum effective dose (MED) value of 50 mg/kg and decreases the number of vasculogenic mimicry channels in tumors when administered at a dose of 100 mg/kg in an HCT116 colon cancer mouse xenograft model. TRX-818 (7.5, 15, and 30 mg/kg) reduces tumor growth in a Hep3B mouse xenograft model in a dose-dependent manner.{53141}  

     

    Brand:
    Cayman
    SKU:22209 -

    Out of stock

  • TRX-818 is an anticancer compound.{53140,53141} It inhibits vasculogenic mimicry network formation in C8161 and SK-MEL-28 melanoma cells when used at concentrations ranging from less than or equal to 5 to 10 nM. {53140} TRX-818 (10 nM) decreases pro-Nodal protein levels and Smad2 phosphorylation in C8161 cells. It reduces tumor volume with a minimum effective dose (MED) value of 50 mg/kg and decreases the number of vasculogenic mimicry channels in tumors when administered at a dose of 100 mg/kg in an HCT116 colon cancer mouse xenograft model. TRX-818 (7.5, 15, and 30 mg/kg) reduces tumor growth in a Hep3B mouse xenograft model in a dose-dependent manner.{53141}  

     

    Brand:
    Cayman
    SKU:22209 -

    Out of stock

  • TRX-818 is an anticancer compound.{53140,53141} It inhibits vasculogenic mimicry network formation in C8161 and SK-MEL-28 melanoma cells when used at concentrations ranging from less than or equal to 5 to 10 nM. {53140} TRX-818 (10 nM) decreases pro-Nodal protein levels and Smad2 phosphorylation in C8161 cells. It reduces tumor volume with a minimum effective dose (MED) value of 50 mg/kg and decreases the number of vasculogenic mimicry channels in tumors when administered at a dose of 100 mg/kg in an HCT116 colon cancer mouse xenograft model. TRX-818 (7.5, 15, and 30 mg/kg) reduces tumor growth in a Hep3B mouse xenograft model in a dose-dependent manner.{53141}  

     

    Brand:
    Cayman
    SKU:22209 -

    Out of stock

  • TRX-818 is an anticancer compound.{53140,53141} It inhibits vasculogenic mimicry network formation in C8161 and SK-MEL-28 melanoma cells when used at concentrations ranging from less than or equal to 5 to 10 nM. {53140} TRX-818 (10 nM) decreases pro-Nodal protein levels and Smad2 phosphorylation in C8161 cells. It reduces tumor volume with a minimum effective dose (MED) value of 50 mg/kg and decreases the number of vasculogenic mimicry channels in tumors when administered at a dose of 100 mg/kg in an HCT116 colon cancer mouse xenograft model. TRX-818 (7.5, 15, and 30 mg/kg) reduces tumor growth in a Hep3B mouse xenograft model in a dose-dependent manner.{53141}  

     

    Brand:
    Cayman
    SKU:22209 -

    Out of stock

  • Brand:
    Cayman
    SKU:10009092 - 1 ea

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  • Trypsin Inhibitor (soybean) is an inhibitor of serine proteases first isolated and characterized by Kunitz.{24215} It dose-dependently inhibits trypsin from a variety of sources, as well as plasma kallikrein, thrombin, plasmin, and other serine proteases.{24215,24214,24216,24218} Trypsin inhibitor (soybean) also partially inhibits chymotrypsin and neutrophil elastase.{24215,24217}  

     

    Brand:
    Cayman
    SKU:-
  • Trypsin Inhibitor (soybean) is an inhibitor of serine proteases first isolated and characterized by Kunitz.{24215} It dose-dependently inhibits trypsin from a variety of sources, as well as plasma kallikrein, thrombin, plasmin, and other serine proteases.{24215,24214,24216,24218} Trypsin inhibitor (soybean) also partially inhibits chymotrypsin and neutrophil elastase.{24215,24217}  

     

    Brand:
    Cayman
    SKU:-
  • Trypsin Inhibitor (soybean) is an inhibitor of serine proteases first isolated and characterized by Kunitz.{24215} It dose-dependently inhibits trypsin from a variety of sources, as well as plasma kallikrein, thrombin, plasmin, and other serine proteases.{24215,24214,24216,24218} Trypsin inhibitor (soybean) also partially inhibits chymotrypsin and neutrophil elastase.{24215,24217}  

     

    Brand:
    Cayman
    SKU:-
  • Tryptamine is an indole alkaloid and intermediate in the biosynthesis of serotonin and the phytohormone melatonin in plants.{36940,36937} It increases the levels of the terpenoid indole alkaloids ajmalicine, strictosidine, and catharanthine in cultures of C. roseus.{36938} Tryptamine is also a product of tryptophan metabolism in mammals.{36936} Tryptamine derivatives have been synthetically produced as hallucinogenic drugs of abuse that act on the serotonergic system.{36939}  

     

    Brand:
    Cayman
    SKU:20995 -

    Out of stock

  • Tryptamine is an indole alkaloid and intermediate in the biosynthesis of serotonin and the phytohormone melatonin in plants.{36940,36937} It increases the levels of the terpenoid indole alkaloids ajmalicine, strictosidine, and catharanthine in cultures of C. roseus.{36938} Tryptamine is also a product of tryptophan metabolism in mammals.{36936} Tryptamine derivatives have been synthetically produced as hallucinogenic drugs of abuse that act on the serotonergic system.{36939}  

     

    Brand:
    Cayman
    SKU:20995 -

    Out of stock

  • Tryptamine is an indole alkaloid and intermediate in the biosynthesis of serotonin and the phytohormone melatonin in plants.{36940,36937} It increases the levels of the terpenoid indole alkaloids ajmalicine, strictosidine, and catharanthine in cultures of C. roseus.{36938} Tryptamine is also a product of tryptophan metabolism in mammals.{36936} Tryptamine derivatives have been synthetically produced as hallucinogenic drugs of abuse that act on the serotonergic system.{36939}  

     

    Brand:
    Cayman
    SKU:20995 -

    Out of stock

  • Tryptamine is an indole alkaloid and intermediate in the biosynthesis of serotonin and the phytohormone melatonin in plants.{36940,36937} It increases the levels of the terpenoid indole alkaloids ajmalicine, strictosidine, and catharanthine in cultures of C. roseus.{36938} Tryptamine is also a product of tryptophan metabolism in mammals.{36936} Tryptamine derivatives have been synthetically produced as hallucinogenic drugs of abuse that act on the serotonergic system.{36939}  

     

    Brand:
    Cayman
    SKU:20995 -

    Out of stock

  • Tryptanthrin is an alkaloid tryptophan derivative originally isolated from various plants and found to have antimicrobial actions. Among its many actions in cells, it inhibits both 5-lipoxygenase and cyclooxygenase-2 (IC50s = 600 and 64 nM, respectively).{29112,29109} Tryptanthrin suppresses angiogenesis in vivo and blocks signaling through VEGFR2 at the level of ERK1/2 signaling in vitro.{29110} It also prevents ERK signaling through Nrf2, reducing oxidative stress-induced hepatocytotoxicity.{29111}  

     

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    Cayman
    SKU:-

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  • Tryptanthrin is an alkaloid tryptophan derivative originally isolated from various plants and found to have antimicrobial actions. Among its many actions in cells, it inhibits both 5-lipoxygenase and cyclooxygenase-2 (IC50s = 600 and 64 nM, respectively).{29112,29109} Tryptanthrin suppresses angiogenesis in vivo and blocks signaling through VEGFR2 at the level of ERK1/2 signaling in vitro.{29110} It also prevents ERK signaling through Nrf2, reducing oxidative stress-induced hepatocytotoxicity.{29111}  

     

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    Cayman
    SKU:-

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  • Tryptanthrin is an alkaloid tryptophan derivative originally isolated from various plants and found to have antimicrobial actions. Among its many actions in cells, it inhibits both 5-lipoxygenase and cyclooxygenase-2 (IC50s = 600 and 64 nM, respectively).{29112,29109} Tryptanthrin suppresses angiogenesis in vivo and blocks signaling through VEGFR2 at the level of ERK1/2 signaling in vitro.{29110} It also prevents ERK signaling through Nrf2, reducing oxidative stress-induced hepatocytotoxicity.{29111}  

     

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    Cayman
    SKU:-

    Available on backorder

  • Tryptanthrin is an alkaloid tryptophan derivative originally isolated from various plants and found to have antimicrobial actions. Among its many actions in cells, it inhibits both 5-lipoxygenase and cyclooxygenase-2 (IC50s = 600 and 64 nM, respectively).{29112,29109} Tryptanthrin suppresses angiogenesis in vivo and blocks signaling through VEGFR2 at the level of ERK1/2 signaling in vitro.{29110} It also prevents ERK signaling through Nrf2, reducing oxidative stress-induced hepatocytotoxicity.{29111}  

     

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    Cayman
    SKU:-

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  • TPH catalyzes the 5-hydroxylation of tryptophan, which is the first step in the biosynthesis of indoleamines (serotonin and melatonin).{14424} In mammals, serotonin biosynthesis occurs predominantly in neurons which originate in the Raphe nuclei of the brain, and melatonin synthesis takes place within the pineal gland. TPH catalyzes the 5-hydroxylation of tryptophan, which is the first step in the biosynthesis of indoleamines (serotonin and melatonin).{14424} In mammals, serotonin biosynthesis occurs predominantly in neurons which originate in the Raphe nuclei of the brain, and melatonin synthesis takes place within the pineal gland. Although TPH catalyzes the same reaction within the Raphe nuclei and the pineal gland, TPH activity is rate-limiting for serotonin but not melatonin biosynthesis. Serotonin functions mainly as a neurotransmitter, whereas melatonin is the principal hormone secreted by the pineal gland. The activity of TPH is enhanced by phosphorylation by cAMP-dependent protein kinase (PKA) and Ca2+/calmodulin kinase II (CaM K II).{14425,14426} CaM K II phosphorylate Ser260 which lies within the regulatory domain of TPH.{14425}  

     

    Brand:
    Cayman
    SKU:10009398 - 1 ea

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  • Antigen: phosphopeptide corresponding to amino acid residues surrounding phospho-Ser260 of rat TPH · Host: rabbit · Cross-reactivity: (+) human and rat TPH; expected to react with bovine, canine, chicken, mouse, and zebrafish TPH · Application: WB  

     

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    Cayman
    SKU:10009398- 1 ea

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  • Antigen: phosphopeptide corresponding to amino acid residues surrounding phospho-Ser260 of rat TPH · Host: rabbit · Cross-reactivity: (+) human and rat TPH; expected to react with bovine, canine, chicken, mouse, and zebrafish TPH · Application: WB  

     

    Brand:
    Cayman
    SKU:10009398- 1 ea
  • Tryptophan hydroxylase (TPH) catalyzes the 5-hydroxylation of tryptophan, which is the first step in the biosynthesis of indoleamines (serotonin and melatonin).{14424} In mammals, serotonin biosynthesis occurs predominantly in neurons which originate in the Raphe nuclei of the brain, and melatonin synthesis takes place within the pineal gland. Although TPH catalyzes the same reaction within the Raphe nuclei and the pineal gland, TPH activity is rate-limiting for serotonin but not melatonin biosynthesis. Serotonin functions mainly as a neurotransmitter, whereas melatonin is the principal hormone secreted by the pineal gland. The activity of TPH is enhanced by phosphorylation by cAMP-dependent protein kinase (PKA) and Ca2+/calmodulin kinase II (CaM K II).{14425,14426} Both PKA and CaM K II phosphorylate Ser58 which lies within the regulatory domain of TPH.{14427}  

     

    Brand:
    Cayman
    SKU:10009397 - 1 ea

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  • Antigen: phosphopeptide corresponding to amino acid residues surrounding phospho-Ser58 of TPH · Host: rabbit · Cross Reactivity: (+) rabbit TPH; expected to react with bovine, canine, human, mouse, non-human primate, rat, Xenopus, and zebrafish TPH · Application: WB  

     

    Brand:
    Cayman
    SKU:10009397- 1 ea

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  • Antigen: phosphopeptide corresponding to amino acid residues surrounding phospho-Ser58 of TPH · Host: rabbit · Cross Reactivity: (+) rabbit TPH; expected to react with bovine, canine, human, mouse, non-human primate, rat, Xenopus, and zebrafish TPH · Application: WB  

     

    Brand:
    Cayman
    SKU:10009397- 1 ea
  • Tryptophan hydroxylase (TPH) catalyzes the first step in the biosynthesis of serotonin and melatonin.{14424} Thus, expression of TPH can be used as an indicator of the localization of serotonin and melatonin in brain. In mammals, serotonin biosynthesis occurs predominantly in neurons which originate in the Raphe nuclei of the brain, and melatonin synthesis takes place within the pineal gland.{14423} Although TPH catalyzes the same reaction within the Raphe nuclei and the pineal gland, TPH activity is rate-limiting for serotonin but not melatonin biosynthesis.{14424}  

     

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    Cayman
    SKU:10009396 - 1 ea

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  • Antigen: recombinant rabbit TPH · Host: sheep · Cross Reactivity: (+) human and rat TPH; expected to react with other mammals; (−) rabbit TPH · Applications: WB and IHC (frozen sections)  

     

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    Cayman
    SKU:10009396- 1 ea

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  • Antigen: recombinant rabbit TPH · Host: sheep · Cross Reactivity: (+) human and rat TPH; expected to react with other mammals; (−) rabbit TPH · Applications: WB and IHC (frozen sections)  

     

    Brand:
    Cayman
    SKU:10009396- 1 ea
  • Tryptophol is an indole that has been found in plants, bacteria, fungi, and sponges and has diverse biological activities, including antifungal, sleep-promoting, and quorum-sensing-related properties.{45419,45418,45420} Tryptophol (100 μM) inhibits the growth of the chytrid fungal skin pathogens B. dendrobatidis and B. salamandrivorans in vitro.{45419} As a quorum-sensing molecule, it also induces autostimulation and increases tryptophol production in B. dendrobatidis and B. salamandrivorans cultures when used at a concentration of 1 μM. Tryptophol (400 mg/kg) induces sleep in mice as assessed by loss of the righting reflex.{45420}  

     

    Brand:
    Cayman
    SKU:28404 - 1 g

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  • Tryptophol is an indole that has been found in plants, bacteria, fungi, and sponges and has diverse biological activities, including antifungal, sleep-promoting, and quorum-sensing-related properties.{45419,45418,45420} Tryptophol (100 μM) inhibits the growth of the chytrid fungal skin pathogens B. dendrobatidis and B. salamandrivorans in vitro.{45419} As a quorum-sensing molecule, it also induces autostimulation and increases tryptophol production in B. dendrobatidis and B. salamandrivorans cultures when used at a concentration of 1 μM. Tryptophol (400 mg/kg) induces sleep in mice as assessed by loss of the righting reflex.{45420}  

     

    Brand:
    Cayman
    SKU:28404 - 10 g

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  • Tryptophol is an indole that has been found in plants, bacteria, fungi, and sponges and has diverse biological activities, including antifungal, sleep-promoting, and quorum-sensing-related properties.{45419,45418,45420} Tryptophol (100 μM) inhibits the growth of the chytrid fungal skin pathogens B. dendrobatidis and B. salamandrivorans in vitro.{45419} As a quorum-sensing molecule, it also induces autostimulation and increases tryptophol production in B. dendrobatidis and B. salamandrivorans cultures when used at a concentration of 1 μM. Tryptophol (400 mg/kg) induces sleep in mice as assessed by loss of the righting reflex.{45420}  

     

    Brand:
    Cayman
    SKU:28404 - 5 g

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  • TS 155-2 is a macrocyclic lactone produced by Streptomyces species found in soil. It has been shown to inhibit thrombin-stimulated calcium entry into cells.{32284}  

     

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    Cayman
    SKU:20689 -

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  • TS 155-2 is a macrocyclic lactone produced by Streptomyces species found in soil. It has been shown to inhibit thrombin-stimulated calcium entry into cells.{32284}  

     

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    Cayman
    SKU:20689 -

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  • Platelet-activating factor (PAF) is a pro-inflammatory phospholipid mediator that is rapidly synthesized by lyso-PAF acetyltransferase (lyso-PAFAT) in response to extracellular stimuli. Two types of lyso-PAFAT have been identified: lysophosphatidylcholine acyltransferase (LPCAT)1, which is mostly expressed in the lungs, and LPCAT2, which is expressed in inflammatory cells. TSI-01 is a selective inhibitor of LPCAT2 (IC50s = 0.47 versus 3.02 µM for human LPCAT2 and LPCAT1, respectively).{28871} At 60 µM it was shown to suppress PAF biosynthesis in mouse peritoneal macrophages stimulated with a calcium ionophore.{28871}  

     

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    Cayman
    SKU:-

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  • Platelet-activating factor (PAF) is a pro-inflammatory phospholipid mediator that is rapidly synthesized by lyso-PAF acetyltransferase (lyso-PAFAT) in response to extracellular stimuli. Two types of lyso-PAFAT have been identified: lysophosphatidylcholine acyltransferase (LPCAT)1, which is mostly expressed in the lungs, and LPCAT2, which is expressed in inflammatory cells. TSI-01 is a selective inhibitor of LPCAT2 (IC50s = 0.47 versus 3.02 µM for human LPCAT2 and LPCAT1, respectively).{28871} At 60 µM it was shown to suppress PAF biosynthesis in mouse peritoneal macrophages stimulated with a calcium ionophore.{28871}  

     

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    Cayman
    SKU:-

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  • Platelet-activating factor (PAF) is a pro-inflammatory phospholipid mediator that is rapidly synthesized by lyso-PAF acetyltransferase (lyso-PAFAT) in response to extracellular stimuli. Two types of lyso-PAFAT have been identified: lysophosphatidylcholine acyltransferase (LPCAT)1, which is mostly expressed in the lungs, and LPCAT2, which is expressed in inflammatory cells. TSI-01 is a selective inhibitor of LPCAT2 (IC50s = 0.47 versus 3.02 µM for human LPCAT2 and LPCAT1, respectively).{28871} At 60 µM it was shown to suppress PAF biosynthesis in mouse peritoneal macrophages stimulated with a calcium ionophore.{28871}  

     

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    Cayman
    SKU:-

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  • Platelet-activating factor (PAF) is a pro-inflammatory phospholipid mediator that is rapidly synthesized by lyso-PAF acetyltransferase (lyso-PAFAT) in response to extracellular stimuli. Two types of lyso-PAFAT have been identified: lysophosphatidylcholine acyltransferase (LPCAT)1, which is mostly expressed in the lungs, and LPCAT2, which is expressed in inflammatory cells. TSI-01 is a selective inhibitor of LPCAT2 (IC50s = 0.47 versus 3.02 µM for human LPCAT2 and LPCAT1, respectively).{28871} At 60 µM it was shown to suppress PAF biosynthesis in mouse peritoneal macrophages stimulated with a calcium ionophore.{28871}  

     

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    Cayman
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  • TTK21 is an activator of CBP/p300 histone acetyltransferase activity.{38921} It activates CBP/p300 histone acetyltransferase activity in a concentration-dependent manner with a maximal effect at a concentration of 275 µM, inducing acetylation of histones H3 and H4 in vitro but not H2B and H2A. TTK21, conjugated to glucose-based carbon nanospheres (CSP), crosses the blood-brain barrier and increases histone acetylation of H2B and H3 as well as H4K12 in mouse frontal cortex and H2B and H3 in the dorsal hippocampus and brainstem. CSP-TTK21 (20 mg/kg) also induces differentiation and maturation of neuronal progenitors in the subgranular zone of the dentate gyrus in adult mice and increases memory duration in the Morris water maze with mice spending more time in the platform quadrant compared with untreated mice up to 16 days after learning.  

     

    Brand:
    Cayman
    SKU:21959 -

    Out of stock

  • TTK21 is an activator of CBP/p300 histone acetyltransferase activity.{38921} It activates CBP/p300 histone acetyltransferase activity in a concentration-dependent manner with a maximal effect at a concentration of 275 µM, inducing acetylation of histones H3 and H4 in vitro but not H2B and H2A. TTK21, conjugated to glucose-based carbon nanospheres (CSP), crosses the blood-brain barrier and increases histone acetylation of H2B and H3 as well as H4K12 in mouse frontal cortex and H2B and H3 in the dorsal hippocampus and brainstem. CSP-TTK21 (20 mg/kg) also induces differentiation and maturation of neuronal progenitors in the subgranular zone of the dentate gyrus in adult mice and increases memory duration in the Morris water maze with mice spending more time in the platform quadrant compared with untreated mice up to 16 days after learning.  

     

    Brand:
    Cayman
    SKU:21959 -

    Out of stock

  • TTK21 is an activator of CBP/p300 histone acetyltransferase activity.{38921} It activates CBP/p300 histone acetyltransferase activity in a concentration-dependent manner with a maximal effect at a concentration of 275 µM, inducing acetylation of histones H3 and H4 in vitro but not H2B and H2A. TTK21, conjugated to glucose-based carbon nanospheres (CSP), crosses the blood-brain barrier and increases histone acetylation of H2B and H3 as well as H4K12 in mouse frontal cortex and H2B and H3 in the dorsal hippocampus and brainstem. CSP-TTK21 (20 mg/kg) also induces differentiation and maturation of neuronal progenitors in the subgranular zone of the dentate gyrus in adult mice and increases memory duration in the Morris water maze with mice spending more time in the platform quadrant compared with untreated mice up to 16 days after learning.  

     

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    Cayman
    SKU:21959 -

    Out of stock

  • TTNPB is an analog of retinoic acid (Item No. 11017) that potently and selectively activates retinoic acid receptors (EC50s = 21, 4, and 2.4 nM for RARα, RARβ, and RARγ, respectively).{27011,23075} It does not act on retinoid X receptors and weakly agonizes farnesoid X receptor (EC50 > 1 µM).{23075,12563} TTNPB is used to study RAR action in diverse processes, including epidermal cell proliferation, embryogenesis, and stem cell differentiation.{27013,27012,25645,27014}  

     

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    Cayman
    SKU:-
  • TTNPB is an analog of retinoic acid (Item No. 11017) that potently and selectively activates retinoic acid receptors (EC50s = 21, 4, and 2.4 nM for RARα, RARβ, and RARγ, respectively).{27011,23075} It does not act on retinoid X receptors and weakly agonizes farnesoid X receptor (EC50 > 1 µM).{23075,12563} TTNPB is used to study RAR action in diverse processes, including epidermal cell proliferation, embryogenesis, and stem cell differentiation.{27013,27012,25645,27014}  

     

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    Cayman
    SKU:-
  • TTNPB is an analog of retinoic acid (Item No. 11017) that potently and selectively activates retinoic acid receptors (EC50s = 21, 4, and 2.4 nM for RARα, RARβ, and RARγ, respectively).{27011,23075} It does not act on retinoid X receptors and weakly agonizes farnesoid X receptor (EC50 > 1 µM).{23075,12563} TTNPB is used to study RAR action in diverse processes, including epidermal cell proliferation, embryogenesis, and stem cell differentiation.{27013,27012,25645,27014}  

     

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    Cayman
    SKU:-
  • TTP 22 is a thienopyrimidine compound that inhibits casein kinase 2 (CK2) with an IC50 value of 100 nM (Ki = 40 nM).{32666} It displays selectivity for CK2 over JNK3, ROCK1, and MET with no inhibitory effects towards these kinases at 10 μM.{32666}  

     

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    Cayman
    SKU:-

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  • TTP 22 is a thienopyrimidine compound that inhibits casein kinase 2 (CK2) with an IC50 value of 100 nM (Ki = 40 nM).{32666} It displays selectivity for CK2 over JNK3, ROCK1, and MET with no inhibitory effects towards these kinases at 10 μM.{32666}  

     

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    Cayman
    SKU:-

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  • TTP 22 is a thienopyrimidine compound that inhibits casein kinase 2 (CK2) with an IC50 value of 100 nM (Ki = 40 nM).{32666} It displays selectivity for CK2 over JNK3, ROCK1, and MET with no inhibitory effects towards these kinases at 10 μM.{32666}  

     

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    Cayman
    SKU:-

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  • TTP 22 is a thienopyrimidine compound that inhibits casein kinase 2 (CK2) with an IC50 value of 100 nM (Ki = 40 nM).{32666} It displays selectivity for CK2 over JNK3, ROCK1, and MET with no inhibitory effects towards these kinases at 10 μM.{32666}  

     

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    Cayman
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  • Tubacin is a tubulin acetylation inducer that selectively inhibits histone deacetylase (HDAC) 6 (IC50 = 4 nM).{18338} In comparison, it demonstrates at least 300-fold selectivity against all other HDAC isoforms (IC50s range from 1.3-17.3 μM).{18338} Tubacin induces α-tubulin hyperacetylation at 2.5 μM in primary cortical neuron cultures.{18338} Tubacin inhibition of HDAC6 has been used as a biochemical tool to control microtubule-dependent intracellular trafficking, to manipulate the aggresome formation of misfolded proteins in certain diseases, and to study the dynamics of cellular adhesion.{22754,16624,21803}  

     

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    Cayman
    SKU:-
  • Tubacin is a tubulin acetylation inducer that selectively inhibits histone deacetylase (HDAC) 6 (IC50 = 4 nM).{18338} In comparison, it demonstrates at least 300-fold selectivity against all other HDAC isoforms (IC50s range from 1.3-17.3 μM).{18338} Tubacin induces α-tubulin hyperacetylation at 2.5 μM in primary cortical neuron cultures.{18338} Tubacin inhibition of HDAC6 has been used as a biochemical tool to control microtubule-dependent intracellular trafficking, to manipulate the aggresome formation of misfolded proteins in certain diseases, and to study the dynamics of cellular adhesion.{22754,16624,21803}  

     

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    Cayman
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  • Tubastatin A is a potent HDAC6 inhibitor with an IC50 value of 15 nM.{18338} Comparatively, it demonstrates over 1,000-fold selectivity against all other HDAC isoforms (IC50s > 16 μM), excluding HDAC8 (IC50 = 0.9 μM).{18338} Tubastatin A induces α-tubulin hyperacetylation at 2.5 μM in primary cortical neuron cultures. In a model of oxidative stress induced by glutathione depletion, tubastatin A displays dose-dependent neuronal protection of primary cortical neuron cultures at 5-10 μM.{18338}  

     

    Brand:
    Cayman
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  • Tubastatin A is a potent HDAC6 inhibitor with an IC50 value of 15 nM.{18338} Comparatively, it demonstrates over 1,000-fold selectivity against all other HDAC isoforms (IC50s > 16 μM), excluding HDAC8 (IC50 = 0.9 μM).{18338} Tubastatin A induces α-tubulin hyperacetylation at 2.5 μM in primary cortical neuron cultures. In a model of oxidative stress induced by glutathione depletion, tubastatin A displays dose-dependent neuronal protection of primary cortical neuron cultures at 5-10 μM.{18338}  

     

    Brand:
    Cayman
    SKU:-
  • Tubastatin A is a potent HDAC6 inhibitor with an IC50 value of 15 nM.{18338} Comparatively, it demonstrates over 1,000-fold selectivity against all other HDAC isoforms (IC50s > 16 μM), excluding HDAC8 (IC50 = 0.9 μM).{18338} Tubastatin A induces α-tubulin hyperacetylation at 2.5 μM in primary cortical neuron cultures. In a model of oxidative stress induced by glutathione depletion, tubastatin A displays dose-dependent neuronal protection of primary cortical neuron cultures at 5-10 μM.{18338}  

     

    Brand:
    Cayman
    SKU:-
  • Tubastatin A is a potent HDAC6 inhibitor with an IC50 value of 15 nM.{18338} Comparatively, it demonstrates over 1,000-fold selectivity against all other HDAC isoforms (IC50s > 16 μM), excluding HDAC8 (IC50 = 0.9 μM).{18338} Tubastatin A induces α-tubulin hyperacetylation at 2.5 μM in primary cortical neuron cultures. In a model of oxidative stress induced by glutathione depletion, tubastatin A displays dose-dependent neuronal protection of primary cortical neuron cultures at 5-10 μM.{18338}  

     

    Brand:
    Cayman
    SKU:-
  • Tubastatin A is a potent HDAC6 inhibitor with an IC50 value of 15 nM.{18338} Comparatively, it demonstrates over 1,000-fold selectivity against all other HDAC isoforms (IC50s >16 μM), excluding HDAC8 (IC50 = 0.9 μM).{18338} Tubastatin A induces α-tubulin hyperacetylation at 2.5 μM in primary cortical neuron cultures. In a model of oxidative stress induced by glutathione depletion, tubastatin A displays dose-dependent neuronal protection of primary cortical neuron cultures at 5-10 μM.{18338}  

     

    Brand:
    Cayman
    SKU:10559 - 1 mg

    Available on backorder

  • Tubastatin A is a potent HDAC6 inhibitor with an IC50 value of 15 nM.{18338} Comparatively, it demonstrates over 1,000-fold selectivity against all other HDAC isoforms (IC50s >16 μM), excluding HDAC8 (IC50 = 0.9 μM).{18338} Tubastatin A induces α-tubulin hyperacetylation at 2.5 μM in primary cortical neuron cultures. In a model of oxidative stress induced by glutathione depletion, tubastatin A displays dose-dependent neuronal protection of primary cortical neuron cultures at 5-10 μM.{18338}  

     

    Brand:
    Cayman
    SKU:10559 - 10 mg

    Available on backorder

  • Tubastatin A is a potent HDAC6 inhibitor with an IC50 value of 15 nM.{18338} Comparatively, it demonstrates over 1,000-fold selectivity against all other HDAC isoforms (IC50s >16 μM), excluding HDAC8 (IC50 = 0.9 μM).{18338} Tubastatin A induces α-tubulin hyperacetylation at 2.5 μM in primary cortical neuron cultures. In a model of oxidative stress induced by glutathione depletion, tubastatin A displays dose-dependent neuronal protection of primary cortical neuron cultures at 5-10 μM.{18338}  

     

    Brand:
    Cayman
    SKU:10559 - 5 mg

    Available on backorder