Cayman
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Ribonucleotide reductase, the rate-limiting enzyme for de novo DNA synthesis, is a common target for chemotherapy. Its increased activity in cancer cells is associated with malignant transformation and proliferation.{14245} Trimidox is a specific ribonucleotide reductase inhibitor that reduces levels of dGTP and dCTP in HL-60 cells, inducing apoptosis via activation of caspases without altering the cell cycle distribution.{14245,15318} Trimidox inhibits growth of human promyelocytic leukemia HL-60 cells with an IC50 value of 35 µM.{14245}
Brand:CaymanSKU:10011124 - 25 mgAvailable on backorder
Ribonucleotide reductase, the rate-limiting enzyme for de novo DNA synthesis, is a common target for chemotherapy. Its increased activity in cancer cells is associated with malignant transformation and proliferation.{14245} Trimidox is a specific ribonucleotide reductase inhibitor that reduces levels of dGTP and dCTP in HL-60 cells, inducing apoptosis via activation of caspases without altering the cell cycle distribution.{14245,15318} Trimidox inhibits growth of human promyelocytic leukemia HL-60 cells with an IC50 value of 35 µM.{14245}
Brand:CaymanSKU:10011124 - 5 mgAvailable on backorder
Ribonucleotide reductase, the rate-limiting enzyme for de novo DNA synthesis, is a common target for chemotherapy. Its increased activity in cancer cells is associated with malignant transformation and proliferation.{14245} Trimidox is a specific ribonucleotide reductase inhibitor that reduces levels of dGTP and dCTP in HL-60 cells, inducing apoptosis via activation of caspases without altering the cell cycle distribution.{14245,15318} Trimidox inhibits growth of human promyelocytic leukemia HL-60 cells with an IC50 value of 35 µM.{14245}
Brand:CaymanSKU:10011124 - 50 mgAvailable on backorder
Trimipramine (maleate) is a tricyclic antidepressant compound that antagonizes several types of neurotransmitter receptors. It is a potent antagonist of histamine H1 (Kd = 0.27 nM), serotonin 5-HT2A, and α1-adrenergic (Kd = 24 nM) receptors.{25914} It demonstrates moderate antagonist activity at dopamine D2 (Kd = 180 nM) and muscarinic acetylcholine (Kd = 58 nM) receptors and weak activity at 5-HT2C, D1, α2-adrenergic (Kd = 680 nM) receptors.{25914} Trimipramine (maleate) is a weak to moderate reuptake inhibitor of serotonin (Ki = 149 nM for SERT), and an extremely weak inhibitor of norepinephrine (Ki = 2.5 µM for NET) and dopamine (Ki = 3.8 µM for DAT) reuptake in slices of rat cerebral cortex.{30236,22877}
Brand:CaymanSKU:-Trimipramine (maleate) is a tricyclic antidepressant compound that antagonizes several types of neurotransmitter receptors. It is a potent antagonist of histamine H1 (Kd = 0.27 nM), serotonin 5-HT2A, and α1-adrenergic (Kd = 24 nM) receptors.{25914} It demonstrates moderate antagonist activity at dopamine D2 (Kd = 180 nM) and muscarinic acetylcholine (Kd = 58 nM) receptors and weak activity at 5-HT2C, D1, α2-adrenergic (Kd = 680 nM) receptors.{25914} Trimipramine (maleate) is a weak to moderate reuptake inhibitor of serotonin (Ki = 149 nM for SERT), and an extremely weak inhibitor of norepinephrine (Ki = 2.5 µM for NET) and dopamine (Ki = 3.8 µM for DAT) reuptake in slices of rat cerebral cortex.{30236,22877}
Brand:CaymanSKU:-Trinactin is a macrotetrolide antibiotic produced by Streptomyces and an ionophore for monovalent cations, such as sodium, potassium, and ammonium.{32290,32288,37789} It is commonly used to facilitate the movement of monovalent cations through natural and artificial lipid membranes.{32288}
Brand:CaymanSKU:25741 - 1 mgAvailable on backorder
Trinactin is a macrotetrolide antibiotic produced by Streptomyces and an ionophore for monovalent cations, such as sodium, potassium, and ammonium.{32290,32288,37789} It is commonly used to facilitate the movement of monovalent cations through natural and artificial lipid membranes.{32288}
Brand:CaymanSKU:25741 - 5 mgAvailable on backorder
Trioxsalen is a derivative of the photoactive probe psoralen (Item No. 11751). Like psoralen, trioxsalen intercalates into DNA and forms DNA single-strand adducts and interstrand crosslinks when activated with ultraviolet light.{31984,31983} It is used to study DNA structure as well as the cellular response to DNA damage. Trioxsalen and other psoralens photosensitize skin cells to ultraviolet light.{31985}
Brand:CaymanSKU:20044 -Available on backorder
Trioxsalen is a derivative of the photoactive probe psoralen (Item No. 11751). Like psoralen, trioxsalen intercalates into DNA and forms DNA single-strand adducts and interstrand crosslinks when activated with ultraviolet light.{31984,31983} It is used to study DNA structure as well as the cellular response to DNA damage. Trioxsalen and other psoralens photosensitize skin cells to ultraviolet light.{31985}
Brand:CaymanSKU:20044 -Available on backorder
Trioxsalen is a derivative of the photoactive probe psoralen (Item No. 11751). Like psoralen, trioxsalen intercalates into DNA and forms DNA single-strand adducts and interstrand crosslinks when activated with ultraviolet light.{31984,31983} It is used to study DNA structure as well as the cellular response to DNA damage. Trioxsalen and other psoralens photosensitize skin cells to ultraviolet light.{31985}
Brand:CaymanSKU:20044 -Available on backorder
Trioxsalen is a derivative of the photoactive probe psoralen (Item No. 11751). Like psoralen, trioxsalen intercalates into DNA and forms DNA single-strand adducts and interstrand crosslinks when activated with ultraviolet light.{31984,31983} It is used to study DNA structure as well as the cellular response to DNA damage. Trioxsalen and other psoralens photosensitize skin cells to ultraviolet light.{31985}
Brand:CaymanSKU:20044 -Available on backorder
Triparanol is a 24-dehydro cholesterol reductase (DHCR24) inhibitor (Ki = 0.523 µM), which is an enzyme involved in the biosynthesis of cholesterol.{34169,34196} It has antitumor properties, such as decreasing proliferation and inducing apoptosis in many cancer cell lines and slowing tumor growth in a mouse xenograft model.{34170} It can also decrease Hedgehog pathway signaling in cancer cells. Formulations containing triparanol were discontinued in the 1960s due to serious adverse side effects, including rapid cataract development.{34171,34172}
Brand:CaymanSKU:20918 -Out of stock
Triparanol is a 24-dehydro cholesterol reductase (DHCR24) inhibitor (Ki = 0.523 µM), which is an enzyme involved in the biosynthesis of cholesterol.{34169,34196} It has antitumor properties, such as decreasing proliferation and inducing apoptosis in many cancer cell lines and slowing tumor growth in a mouse xenograft model.{34170} It can also decrease Hedgehog pathway signaling in cancer cells. Formulations containing triparanol were discontinued in the 1960s due to serious adverse side effects, including rapid cataract development.{34171,34172}
Brand:CaymanSKU:20918 -Out of stock
Triparanol is a 24-dehydro cholesterol reductase (DHCR24) inhibitor (Ki = 0.523 µM), which is an enzyme involved in the biosynthesis of cholesterol.{34169,34196} It has antitumor properties, such as decreasing proliferation and inducing apoptosis in many cancer cell lines and slowing tumor growth in a mouse xenograft model.{34170} It can also decrease Hedgehog pathway signaling in cancer cells. Formulations containing triparanol were discontinued in the 1960s due to serious adverse side effects, including rapid cataract development.{34171,34172}
Brand:CaymanSKU:20918 -Out of stock
Triparanol is a 24-dehydro cholesterol reductase (DHCR24) inhibitor (Ki = 0.523 µM), which is an enzyme involved in the biosynthesis of cholesterol.{34169,34196} It has antitumor properties, such as decreasing proliferation and inducing apoptosis in many cancer cell lines and slowing tumor growth in a mouse xenograft model.{34170} It can also decrease Hedgehog pathway signaling in cancer cells. Formulations containing triparanol were discontinued in the 1960s due to serious adverse side effects, including rapid cataract development.{34171,34172}
Brand:CaymanSKU:20918 -Out of stock
Triphenylphosphine oxide (TPPO) is a coordinating solvent used to activate crystallization of chemical compounds. It has been used in flame retardant applications, as an epoxy cure catalyst, and more recently, to produce nanostructures.
Brand:CaymanSKU:9000289 - 1 gAvailable on backorder
Triphenylphosphine oxide (TPPO) is a coordinating solvent used to activate crystallization of chemical compounds. It has been used in flame retardant applications, as an epoxy cure catalyst, and more recently, to produce nanostructures.
Brand:CaymanSKU:9000289 - 25 mgAvailable on backorder
Triphenylphosphine oxide (TPPO) is a coordinating solvent used to activate crystallization of chemical compounds. It has been used in flame retardant applications, as an epoxy cure catalyst, and more recently, to produce nanostructures.
Brand:CaymanSKU:9000289 - 50 mgAvailable on backorder
Triphenylphosphine oxide (TPPO) is a coordinating solvent used to activate crystallization of chemical compounds. It has been used in flame retardant applications, as an epoxy cure catalyst, and more recently, to produce nanostructures.
Brand:CaymanSKU:9000289 - 500 mgAvailable on backorder
Triptolide is the major bioactive constituent of T. wilfordii Hook F., also known as thunder god vine, a traditional Chinese medicinal herb with known antiproliferative, immunosuppressive, anti-inflammatory, antifertility, and anti-polycystic kidney disease effects. Triptolide binds to and inhibits human dCTP pyrophosphatase 1, a “gatekeeper” enzyme that prevents deleterious halogenated nucleotides from entering DNA synthesis, with a Ki value of 168 μM and an IC50 value of 7-10 nM.{22058} Triptolide has also been shown to inhibit LPS-stimulated induction of cyclooxygenase 2 mRNA and synthesis of prostaglandin E2 in human peripheral blood monocytes, rheumatoid arthritis synovial fibroblasts, and human neonatal foreskin fibroblasts with an IC50 value of 0.04 μM.{22057}
Brand:CaymanSKU:11973 - 1 mgAvailable on backorder
Triptolide is the major bioactive constituent of T. wilfordii Hook F., also known as thunder god vine, a traditional Chinese medicinal herb with known antiproliferative, immunosuppressive, anti-inflammatory, antifertility, and anti-polycystic kidney disease effects. Triptolide binds to and inhibits human dCTP pyrophosphatase 1, a “gatekeeper” enzyme that prevents deleterious halogenated nucleotides from entering DNA synthesis, with a Ki value of 168 μM and an IC50 value of 7-10 nM.{22058} Triptolide has also been shown to inhibit LPS-stimulated induction of cyclooxygenase 2 mRNA and synthesis of prostaglandin E2 in human peripheral blood monocytes, rheumatoid arthritis synovial fibroblasts, and human neonatal foreskin fibroblasts with an IC50 value of 0.04 μM.{22057}
Brand:CaymanSKU:11973 - 10 mgAvailable on backorder
Triptolide is the major bioactive constituent of T. wilfordii Hook F., also known as thunder god vine, a traditional Chinese medicinal herb with known antiproliferative, immunosuppressive, anti-inflammatory, antifertility, and anti-polycystic kidney disease effects. Triptolide binds to and inhibits human dCTP pyrophosphatase 1, a “gatekeeper” enzyme that prevents deleterious halogenated nucleotides from entering DNA synthesis, with a Ki value of 168 μM and an IC50 value of 7-10 nM.{22058} Triptolide has also been shown to inhibit LPS-stimulated induction of cyclooxygenase 2 mRNA and synthesis of prostaglandin E2 in human peripheral blood monocytes, rheumatoid arthritis synovial fibroblasts, and human neonatal foreskin fibroblasts with an IC50 value of 0.04 μM.{22057}
Brand:CaymanSKU:11973 - 5 mgAvailable on backorder
Triptorelin is a synthetic gonadotropin-releasing hormone (GnRH) peptide agonist that binds to the GnRH receptor (GnRHR; Ki = 0.3 nM in CHO cells expressing the human receptor).{36464} It inhibits the growth of DU145, LNCaP, and PC3 prostate and OVCAR-3 ovarian cancer cells (IC50s = 62.1, 73.4, 98.1, and 67.7 μM, respectively).{52097} Triptorelin also inhibits the growth of the triple-negative breast cancer (TNBC) cell lines HCC1806 and MDA-MB-231 (EC50s = 58.29 and 31.59 μM, respectively).{52096} It stimulates follicle stimulating hormone (FSH) and luteinizing hormone (LH) release from primary rat pituitary cells when used at a concentration of 50 nM.{52097} It also decreases tumor volume of Dunning R3327H prostate tumor flank implants and reduces prostate and testis weight in rats when administered at a dose of 1 mg/kg per day.{39555} Formulations containing triptorelin have been used in the palliative treatment of advanced prostate cancer.
Brand:CaymanSKU:28613 - 10 mgAvailable on backorder
Triptorelin is a synthetic gonadotropin-releasing hormone (GnRH) peptide agonist that binds to the GnRH receptor (GnRHR; Ki = 0.3 nM in CHO cells expressing the human receptor).{36464} It inhibits the growth of DU145, LNCaP, and PC3 prostate and OVCAR-3 ovarian cancer cells (IC50s = 62.1, 73.4, 98.1, and 67.7 μM, respectively).{52097} Triptorelin also inhibits the growth of the triple-negative breast cancer (TNBC) cell lines HCC1806 and MDA-MB-231 (EC50s = 58.29 and 31.59 μM, respectively).{52096} It stimulates follicle stimulating hormone (FSH) and luteinizing hormone (LH) release from primary rat pituitary cells when used at a concentration of 50 nM.{52097} It also decreases tumor volume of Dunning R3327H prostate tumor flank implants and reduces prostate and testis weight in rats when administered at a dose of 1 mg/kg per day.{39555} Formulations containing triptorelin have been used in the palliative treatment of advanced prostate cancer.
Brand:CaymanSKU:28613 - 25 mgAvailable on backorder
Triptorelin is a synthetic gonadotropin-releasing hormone (GnRH) peptide agonist that binds to the GnRH receptor (GnRHR; Ki = 0.3 nM in CHO cells expressing the human receptor).{36464} It inhibits the growth of DU145, LNCaP, and PC3 prostate and OVCAR-3 ovarian cancer cells (IC50s = 62.1, 73.4, 98.1, and 67.7 μM, respectively).{52097} Triptorelin also inhibits the growth of the triple-negative breast cancer (TNBC) cell lines HCC1806 and MDA-MB-231 (EC50s = 58.29 and 31.59 μM, respectively).{52096} It stimulates follicle stimulating hormone (FSH) and luteinizing hormone (LH) release from primary rat pituitary cells when used at a concentration of 50 nM.{52097} It also decreases tumor volume of Dunning R3327H prostate tumor flank implants and reduces prostate and testis weight in rats when administered at a dose of 1 mg/kg per day.{39555} Formulations containing triptorelin have been used in the palliative treatment of advanced prostate cancer.
Brand:CaymanSKU:28613 - 5 mgAvailable on backorder
Brand:CaymanSKU:700751 - 5 mlAvailable on backorder
Tris(4,7-diphenyl-1,10-phenanthroline)ruthenium II dichloride complex is a luminescent probe (absorption λmax: 455 nm, luminescence λmax: 613 nm) widely used for detection and quantitation of oxygen.{26592} The dye is strongly reduced by molecular oxygen as a result of dynamic quenching; thus oxygen detection can be based on either measurement of intensity or decay time.{26591} This oxygen probe has been used to optimize optical oxygen sensors, to measure oxygen flux through tissues and in skin tumors, and for oxygen imaging.{26592,26594,26604,26590,26593}
Brand:CaymanSKU:-Tris(4,7-diphenyl-1,10-phenanthroline)ruthenium II dichloride complex is a luminescent probe (absorption λmax: 455 nm, luminescence λmax: 613 nm) widely used for detection and quantitation of oxygen.{26592} The dye is strongly reduced by molecular oxygen as a result of dynamic quenching; thus oxygen detection can be based on either measurement of intensity or decay time.{26591} This oxygen probe has been used to optimize optical oxygen sensors, to measure oxygen flux through tissues and in skin tumors, and for oxygen imaging.{26592,26594,26604,26590,26593}
Brand:CaymanSKU:-Tris(4,7-diphenyl-1,10-phenanthroline)ruthenium II dichloride complex is a luminescent probe (absorption λmax: 455 nm, luminescence λmax: 613 nm) widely used for detection and quantitation of oxygen.{26592} The dye is strongly reduced by molecular oxygen as a result of dynamic quenching; thus oxygen detection can be based on either measurement of intensity or decay time.{26591} This oxygen probe has been used to optimize optical oxygen sensors, to measure oxygen flux through tissues and in skin tumors, and for oxygen imaging.{26592,26594,26604,26590,26593}
Brand:CaymanSKU:-Tris(4,7-diphenyl-1,10-phenanthroline)ruthenium II dichloride complex is a luminescent probe (absorption λmax: 455 nm, luminescence λmax: 613 nm) widely used for detection and quantitation of oxygen.{26592} The dye is strongly reduced by molecular oxygen as a result of dynamic quenching; thus oxygen detection can be based on either measurement of intensity or decay time.{26591} This oxygen probe has been used to optimize optical oxygen sensors, to measure oxygen flux through tissues and in skin tumors, and for oxygen imaging.{26592,26594,26604,26590,26593}
Brand:CaymanSKU:-Triticonazole is a triazole fungicide used for the control of common soil and seed-borne diseases on cereals and other crops.{30331} The antifungal effects of triticonazole are due to its ability to inhibit ergosterol biosynthesis.{30331}
Brand:CaymanSKU:-Available on backorder
TRO 19622 is an orally bioavailable mitochondrial-targeted neuroprotective agent that binds to and inhibits opening of the mitochondrial permeability transition pore (mPTP).{39891,39892} It prevents mPTP opening induced by arachidonic acid (Item No. 90010) in HeLa cells when used at a concentration of 10 µM.{39891} TRO 19622 promotes survival of motor neurons in vitro in a concentration-dependent manner in the absence of neurotrophic factors (EC50 = 3.2 µM) and in vivo in a neonatal rat model of facial nerve axotomy when administered at a dose of 100 mg/kg per day.{39892} It delays onset of motor deficits and extends survival in the SOD1G93A transgenic model of amyotrophic lateral sclerosis (ALS). TRO 19622 (30 and 100 mg/kg) also increases the latency to paw withdrawal in a mechanical hyperalgesia test in rat models of streptozotocin-induced diabetic and vincristine-induced neuropathic pain but not in models of acute, inflammatory, or injury-induced pain.{39893}
Brand:CaymanSKU:21264 -Out of stock
TRO 19622 is an orally bioavailable mitochondrial-targeted neuroprotective agent that binds to and inhibits opening of the mitochondrial permeability transition pore (mPTP).{39891,39892} It prevents mPTP opening induced by arachidonic acid (Item No. 90010) in HeLa cells when used at a concentration of 10 µM.{39891} TRO 19622 promotes survival of motor neurons in vitro in a concentration-dependent manner in the absence of neurotrophic factors (EC50 = 3.2 µM) and in vivo in a neonatal rat model of facial nerve axotomy when administered at a dose of 100 mg/kg per day.{39892} It delays onset of motor deficits and extends survival in the SOD1G93A transgenic model of amyotrophic lateral sclerosis (ALS). TRO 19622 (30 and 100 mg/kg) also increases the latency to paw withdrawal in a mechanical hyperalgesia test in rat models of streptozotocin-induced diabetic and vincristine-induced neuropathic pain but not in models of acute, inflammatory, or injury-induced pain.{39893}
Brand:CaymanSKU:21264 -Out of stock
TRO 19622 is an orally bioavailable mitochondrial-targeted neuroprotective agent that binds to and inhibits opening of the mitochondrial permeability transition pore (mPTP).{39891,39892} It prevents mPTP opening induced by arachidonic acid (Item No. 90010) in HeLa cells when used at a concentration of 10 µM.{39891} TRO 19622 promotes survival of motor neurons in vitro in a concentration-dependent manner in the absence of neurotrophic factors (EC50 = 3.2 µM) and in vivo in a neonatal rat model of facial nerve axotomy when administered at a dose of 100 mg/kg per day.{39892} It delays onset of motor deficits and extends survival in the SOD1G93A transgenic model of amyotrophic lateral sclerosis (ALS). TRO 19622 (30 and 100 mg/kg) also increases the latency to paw withdrawal in a mechanical hyperalgesia test in rat models of streptozotocin-induced diabetic and vincristine-induced neuropathic pain but not in models of acute, inflammatory, or injury-induced pain.{39893}
Brand:CaymanSKU:21264 -Out of stock
Trofosfamide is a nitrogen mustard alkylating agent and a derivative of cyclophosphamide (Item No. 13849) that has antiproliferative activities.{52010,52011} It increases the number of micronucleated polychromatic red blood cells isolated from mouse bone marrow, indicating cytogenetic activity, when administered at doses of 40, 80, and 160 mg/kg.{52009} Trofosfamide (100 mg/kg) inhibits proliferation of isolated splenocytes in the allogenic mixed lymphocyte reaction.{52010} It reduces sheep red blood cell-induced increases in the number of antibody-producing spleen cells isolated from rats when administered at a dose of 40 mg/kg.{52011}
Brand:CaymanSKU:21874 -Out of stock
Trofosfamide is a nitrogen mustard alkylating agent and a derivative of cyclophosphamide (Item No. 13849) that has antiproliferative activities.{52010,52011} It increases the number of micronucleated polychromatic red blood cells isolated from mouse bone marrow, indicating cytogenetic activity, when administered at doses of 40, 80, and 160 mg/kg.{52009} Trofosfamide (100 mg/kg) inhibits proliferation of isolated splenocytes in the allogenic mixed lymphocyte reaction.{52010} It reduces sheep red blood cell-induced increases in the number of antibody-producing spleen cells isolated from rats when administered at a dose of 40 mg/kg.{52011}
Brand:CaymanSKU:21874 -Out of stock
Trofosfamide is a nitrogen mustard alkylating agent and a derivative of cyclophosphamide (Item No. 13849) that has antiproliferative activities.{52010,52011} It increases the number of micronucleated polychromatic red blood cells isolated from mouse bone marrow, indicating cytogenetic activity, when administered at doses of 40, 80, and 160 mg/kg.{52009} Trofosfamide (100 mg/kg) inhibits proliferation of isolated splenocytes in the allogenic mixed lymphocyte reaction.{52010} It reduces sheep red blood cell-induced increases in the number of antibody-producing spleen cells isolated from rats when administered at a dose of 40 mg/kg.{52011}
Brand:CaymanSKU:21874 -Out of stock
Trofosfamide is a nitrogen mustard alkylating agent and a derivative of cyclophosphamide (Item No. 13849) that has antiproliferative activities.{52010,52011} It increases the number of micronucleated polychromatic red blood cells isolated from mouse bone marrow, indicating cytogenetic activity, when administered at doses of 40, 80, and 160 mg/kg.{52009} Trofosfamide (100 mg/kg) inhibits proliferation of isolated splenocytes in the allogenic mixed lymphocyte reaction.{52010} It reduces sheep red blood cell-induced increases in the number of antibody-producing spleen cells isolated from rats when administered at a dose of 40 mg/kg.{52011}
Brand:CaymanSKU:21874 -Out of stock
Troglitazone is a selective agonist of peroxisome proliferator-activated receptor γ (PPARγ; EC50s = 0.78 and 0.55 μM for the mouse and human receptors, respectively, in a transactivation assay).{10670} It is selective for PPARγ over PPARα and PPARδ, at which it is inactive at concentrations up to 10 μM. Troglitazone (500 mg/kg twice per day) exhibits antihyperglycemic and antihyperlipidemic properties in Zucker diabetic fatty rats, reducing plasma glucose and triglyceride levels by 61 and 87% respectively.{25251} It also induces cell cycle arrest at the G1 phase in SK-HEP-1 and Hep3B hepatocellular carcinoma cells when used at a concentration of 10 μM and increases apoptosis in these cells at concentrations of 30 μM and higher.{10669}
Brand:CaymanSKU:71750 - 10 mgAvailable on backorder
Troglitazone is a selective agonist of peroxisome proliferator-activated receptor γ (PPARγ; EC50s = 0.78 and 0.55 μM for the mouse and human receptors, respectively, in a transactivation assay).{10670} It is selective for PPARγ over PPARα and PPARδ, at which it is inactive at concentrations up to 10 μM. Troglitazone (500 mg/kg twice per day) exhibits antihyperglycemic and antihyperlipidemic properties in Zucker diabetic fatty rats, reducing plasma glucose and triglyceride levels by 61 and 87% respectively.{25251} It also induces cell cycle arrest at the G1 phase in SK-HEP-1 and Hep3B hepatocellular carcinoma cells when used at a concentration of 10 μM and increases apoptosis in these cells at concentrations of 30 μM and higher.{10669}
Brand:CaymanSKU:71750 - 100 mgAvailable on backorder
Troglitazone is a selective agonist of peroxisome proliferator-activated receptor γ (PPARγ; EC50s = 0.78 and 0.55 μM for the mouse and human receptors, respectively, in a transactivation assay).{10670} It is selective for PPARγ over PPARα and PPARδ, at which it is inactive at concentrations up to 10 μM. Troglitazone (500 mg/kg twice per day) exhibits antihyperglycemic and antihyperlipidemic properties in Zucker diabetic fatty rats, reducing plasma glucose and triglyceride levels by 61 and 87% respectively.{25251} It also induces cell cycle arrest at the G1 phase in SK-HEP-1 and Hep3B hepatocellular carcinoma cells when used at a concentration of 10 μM and increases apoptosis in these cells at concentrations of 30 μM and higher.{10669}
Brand:CaymanSKU:71750 - 5 mgAvailable on backorder
Troglitazone is a selective agonist of peroxisome proliferator-activated receptor γ (PPARγ; EC50s = 0.78 and 0.55 μM for the mouse and human receptors, respectively, in a transactivation assay).{10670} It is selective for PPARγ over PPARα and PPARδ, at which it is inactive at concentrations up to 10 μM. Troglitazone (500 mg/kg twice per day) exhibits antihyperglycemic and antihyperlipidemic properties in Zucker diabetic fatty rats, reducing plasma glucose and triglyceride levels by 61 and 87% respectively.{25251} It also induces cell cycle arrest at the G1 phase in SK-HEP-1 and Hep3B hepatocellular carcinoma cells when used at a concentration of 10 μM and increases apoptosis in these cells at concentrations of 30 μM and higher.{10669}
Brand:CaymanSKU:71750 - 50 mgAvailable on backorder
Trolox is a cell-permeable, water-soluble derivative of vitamin E with potent antioxidant properties. It is commonly used as a standard or positive control in antioxidant assays.{12069,13782} In addition, trolox is used to assess the role of oxidative injury in processes like neuronal cell death and aging.{16492,16490} Trolox is effective as adjunctive therapy in the treatment of certain cancers.{16491}
Brand:CaymanSKU:10011659 - 1 gAvailable on backorder
Trolox is a cell-permeable, water-soluble derivative of vitamin E with potent antioxidant properties. It is commonly used as a standard or positive control in antioxidant assays.{12069,13782} In addition, trolox is used to assess the role of oxidative injury in processes like neuronal cell death and aging.{16492,16490} Trolox is effective as adjunctive therapy in the treatment of certain cancers.{16491}
Brand:CaymanSKU:10011659 - 250 mgAvailable on backorder
Trolox is a cell-permeable, water-soluble derivative of vitamin E with potent antioxidant properties. It is commonly used as a standard or positive control in antioxidant assays.{12069,13782} In addition, trolox is used to assess the role of oxidative injury in processes like neuronal cell death and aging.{16492,16490} Trolox is effective as adjunctive therapy in the treatment of certain cancers.{16491}
Brand:CaymanSKU:10011659 - 500 mgAvailable on backorder
Muscarinic receptors are G protein-coupled acetylcholine receptors that play diverse roles. Five subtypes (M1-5) have been identified, which preferentially couple to various effector systems based on their G protein interaction.{27107,27108}Tropicamide is a muscarinic acetylcholine receptor (mAChR) antagonist (pKi = 7.2 in chicken heart) that displays 3-fold selectivity for M4.{27107,27106,27105} When applied as eye drops, it produces temporary mydriasis (pupil dilation; EC50 = 6 µg/ml) and cycloplegia (ciliary muscle paralysis; EC50 = 25 µg/ml).{27109} Tropicamide has been used to probe mAChR activity in a mouse model of fragile X syndrome.{27110}
Brand:CaymanSKU:-Out of stock
Muscarinic receptors are G protein-coupled acetylcholine receptors that play diverse roles. Five subtypes (M1-5) have been identified, which preferentially couple to various effector systems based on their G protein interaction.{27107,27108}Tropicamide is a muscarinic acetylcholine receptor (mAChR) antagonist (pKi = 7.2 in chicken heart) that displays 3-fold selectivity for M4.{27107,27106,27105} When applied as eye drops, it produces temporary mydriasis (pupil dilation; EC50 = 6 µg/ml) and cycloplegia (ciliary muscle paralysis; EC50 = 25 µg/ml).{27109} Tropicamide has been used to probe mAChR activity in a mouse model of fragile X syndrome.{27110}
Brand:CaymanSKU:-Out of stock
Tropifexor is an agonist of farnesoid X receptors (FXR).{48126} It enhances the interaction between the human FXR ligand binding domain and the steroid receptor coactivator 1 (SRC-1) peptide in a homogeneous time-resolved fluorescence (HTRF) coactivator interaction assay (EC50 = 0.2 nM). It increases expression of the FXR target genes BSEP and SHP and decreases expression of CPY8B1 in rat liver in a dose-dependent manner, as well as increases expression of SHP and FGF15 in rat ileum. Tropifexor (0.3 mg/kg) reduces triglyceride levels by 79% in rat serum. It reduces fibrosis, inflammation, and steatosis in a mouse model of nonalcoholic steatohepatitis (NASH).{48127}
Brand:CaymanSKU:25748 - 1 mgAvailable on backorder
Tropifexor is an agonist of farnesoid X receptors (FXR).{48126} It enhances the interaction between the human FXR ligand binding domain and the steroid receptor coactivator 1 (SRC-1) peptide in a homogeneous time-resolved fluorescence (HTRF) coactivator interaction assay (EC50 = 0.2 nM). It increases expression of the FXR target genes BSEP and SHP and decreases expression of CPY8B1 in rat liver in a dose-dependent manner, as well as increases expression of SHP and FGF15 in rat ileum. Tropifexor (0.3 mg/kg) reduces triglyceride levels by 79% in rat serum. It reduces fibrosis, inflammation, and steatosis in a mouse model of nonalcoholic steatohepatitis (NASH).{48127}
Brand:CaymanSKU:25748 - 10 mgAvailable on backorder
Tropifexor is an agonist of farnesoid X receptors (FXR).{48126} It enhances the interaction between the human FXR ligand binding domain and the steroid receptor coactivator 1 (SRC-1) peptide in a homogeneous time-resolved fluorescence (HTRF) coactivator interaction assay (EC50 = 0.2 nM). It increases expression of the FXR target genes BSEP and SHP and decreases expression of CPY8B1 in rat liver in a dose-dependent manner, as well as increases expression of SHP and FGF15 in rat ileum. Tropifexor (0.3 mg/kg) reduces triglyceride levels by 79% in rat serum. It reduces fibrosis, inflammation, and steatosis in a mouse model of nonalcoholic steatohepatitis (NASH).{48127}
Brand:CaymanSKU:25748 - 5 mgAvailable on backorder
Tropifexor is an agonist of farnesoid X receptors (FXR).{48126} It enhances the interaction between the human FXR ligand binding domain and the steroid receptor coactivator 1 (SRC-1) peptide in a homogeneous time-resolved fluorescence (HTRF) coactivator interaction assay (EC50 = 0.2 nM). It increases expression of the FXR target genes BSEP and SHP and decreases expression of CPY8B1 in rat liver in a dose-dependent manner, as well as increases expression of SHP and FGF15 in rat ileum. Tropifexor (0.3 mg/kg) reduces triglyceride levels by 79% in rat serum. It reduces fibrosis, inflammation, and steatosis in a mouse model of nonalcoholic steatohepatitis (NASH).{48127}
Brand:CaymanSKU:25748 - 500 µgAvailable on backorder
Tropine is a naturally-occurring tropane alkaloid extracted primarily from plants of the Solanaceae family.{22119} It serves as an intermediate in the synthesis of a variety of bioactive alkaloids, including atropine (Item No. 12008), benztropine (Item No. 18214), and scopolamine, many of which have potent neurological actions.{22119,30247}
Brand:CaymanSKU:-Available on backorder
Tropine is a naturally-occurring tropane alkaloid extracted primarily from plants of the Solanaceae family.{22119} It serves as an intermediate in the synthesis of a variety of bioactive alkaloids, including atropine (Item No. 12008), benztropine (Item No. 18214), and scopolamine, many of which have potent neurological actions.{22119,30247}
Brand:CaymanSKU:-Available on backorder
Tropine is a naturally-occurring tropane alkaloid extracted primarily from plants of the Solanaceae family.{22119} It serves as an intermediate in the synthesis of a variety of bioactive alkaloids, including atropine (Item No. 12008), benztropine (Item No. 18214), and scopolamine, many of which have potent neurological actions.{22119,30247}
Brand:CaymanSKU:-Available on backorder
Tropine is a naturally-occurring tropane alkaloid extracted primarily from plants of the Solanaceae family.{22119} It serves as an intermediate in the synthesis of a variety of bioactive alkaloids, including atropine (Item No. 12008), benztropine (Item No. 18214), and scopolamine, many of which have potent neurological actions.{22119,30247}
Brand:CaymanSKU:-Available on backorder
Tropisetron is an orally-bioavailable antagonist of the serotonin (5-HT) receptor 5-HT3 (Ki = 5.3 nM).{33369,33371} Antagonists of 5-HT3, including tropisetron, have been shown to prevent nausea and emesis in patients undergoing chemotherapy in clinical trials.{33373,33374} Tropisetron is also an antagonist of the α9 nicotinic acetylcholine receptor (nAChR; IC50 = 166 nM) and a partial agonist of α7 nAChR (Ki = 6.9 nM).{33372,33370}
Brand:CaymanSKU:21240 -Out of stock
Tropisetron is an orally-bioavailable antagonist of the serotonin (5-HT) receptor 5-HT3 (Ki = 5.3 nM).{33369,33371} Antagonists of 5-HT3, including tropisetron, have been shown to prevent nausea and emesis in patients undergoing chemotherapy in clinical trials.{33373,33374} Tropisetron is also an antagonist of the α9 nicotinic acetylcholine receptor (nAChR; IC50 = 166 nM) and a partial agonist of α7 nAChR (Ki = 6.9 nM).{33372,33370}
Brand:CaymanSKU:21240 -Out of stock
Tropisetron is an orally-bioavailable antagonist of the serotonin (5-HT) receptor 5-HT3 (Ki = 5.3 nM).{33369,33371} Antagonists of 5-HT3, including tropisetron, have been shown to prevent nausea and emesis in patients undergoing chemotherapy in clinical trials.{33373,33374} Tropisetron is also an antagonist of the α9 nicotinic acetylcholine receptor (nAChR; IC50 = 166 nM) and a partial agonist of α7 nAChR (Ki = 6.9 nM).{33372,33370}
Brand:CaymanSKU:21240 -Out of stock
Tropisetron is an orally-bioavailable antagonist of the serotonin (5-HT) receptor 5-HT3 (Ki = 5.3 nM).{33369,33371} Antagonists of 5-HT3, including tropisetron, have been shown to prevent nausea and emesis in patients undergoing chemotherapy in clinical trials.{33373,33374} Tropisetron is also an antagonist of the α9 nicotinic acetylcholine receptor (nAChR; IC50 = 166 nM) and a partial agonist of α7 nAChR (Ki = 6.9 nM).{33372,33370}
Brand:CaymanSKU:21240 -Out of stock
Tropodithietic acid (TDA) is a broad-spectrum antibiotic produced by the marine bacterium R. gallaeciensis.{38281} It is active against a variety of Gram-negative α-proteobacteria, γ-proteobacteria, and flavobacteria as well as Gram-positive actinobacteria strains in a disc assay. TDA also inhibits the growth of S. aureus and V. anguillarum with MIC values of 39 and 19 μM, respectively.{38282}
Brand:CaymanSKU:23244 - 1 mgAvailable on backorder
Tropolone is a terpene that has been found in cupressaceous tree bark and has diverse biological activities.{52319,52320,52321,52322,52323} It inhibits catechol O-methyltransferase (COMT; Ki = 22 µM).{52319} Tropolone is bacteriostatic against a panel of Gram-positive and Gram-negative bacteria (MICs = 12-82 µM) and bactericidal against A. hydrophilia and C. violaceum when used at a concentration of 20 mM.{52320} It is an iron chelator that inhibits iron-dependent growth of the wood rot fungus P. placenta when used at a concentration of 50 µM and P. placenta degradation of pine sapwood blocks impregnated with 5 mM tropolone.{52321} It inhibits LPS-induced production of nitric oxide (NO) in RAW 264.7 cells (IC50 = 12 µM).{52322} Tropolone (0.25 mmol/animal) reduces thyroid radioiodide uptake in rats.{52323} Dietary administration of tropolone induces growth retardation and hyperactivity in mice.
Brand:CaymanSKU:29674 - 1 mgAvailable on backorder
Tropolone is a terpene that has been found in cupressaceous tree bark and has diverse biological activities.{52319,52320,52321,52322,52323} It inhibits catechol O-methyltransferase (COMT; Ki = 22 µM).{52319} Tropolone is bacteriostatic against a panel of Gram-positive and Gram-negative bacteria (MICs = 12-82 µM) and bactericidal against A. hydrophilia and C. violaceum when used at a concentration of 20 mM.{52320} It is an iron chelator that inhibits iron-dependent growth of the wood rot fungus P. placenta when used at a concentration of 50 µM and P. placenta degradation of pine sapwood blocks impregnated with 5 mM tropolone.{52321} It inhibits LPS-induced production of nitric oxide (NO) in RAW 264.7 cells (IC50 = 12 µM).{52322} Tropolone (0.25 mmol/animal) reduces thyroid radioiodide uptake in rats.{52323} Dietary administration of tropolone induces growth retardation and hyperactivity in mice.
Brand:CaymanSKU:29674 - 10 mgAvailable on backorder
Tropolone is a terpene that has been found in cupressaceous tree bark and has diverse biological activities.{52319,52320,52321,52322,52323} It inhibits catechol O-methyltransferase (COMT; Ki = 22 µM).{52319} Tropolone is bacteriostatic against a panel of Gram-positive and Gram-negative bacteria (MICs = 12-82 µM) and bactericidal against A. hydrophilia and C. violaceum when used at a concentration of 20 mM.{52320} It is an iron chelator that inhibits iron-dependent growth of the wood rot fungus P. placenta when used at a concentration of 50 µM and P. placenta degradation of pine sapwood blocks impregnated with 5 mM tropolone.{52321} It inhibits LPS-induced production of nitric oxide (NO) in RAW 264.7 cells (IC50 = 12 µM).{52322} Tropolone (0.25 mmol/animal) reduces thyroid radioiodide uptake in rats.{52323} Dietary administration of tropolone induces growth retardation and hyperactivity in mice.
Brand:CaymanSKU:29674 - 25 mgAvailable on backorder
Tropolone is a terpene that has been found in cupressaceous tree bark and has diverse biological activities.{52319,52320,52321,52322,52323} It inhibits catechol O-methyltransferase (COMT; Ki = 22 µM).{52319} Tropolone is bacteriostatic against a panel of Gram-positive and Gram-negative bacteria (MICs = 12-82 µM) and bactericidal against A. hydrophilia and C. violaceum when used at a concentration of 20 mM.{52320} It is an iron chelator that inhibits iron-dependent growth of the wood rot fungus P. placenta when used at a concentration of 50 µM and P. placenta degradation of pine sapwood blocks impregnated with 5 mM tropolone.{52321} It inhibits LPS-induced production of nitric oxide (NO) in RAW 264.7 cells (IC50 = 12 µM).{52322} Tropolone (0.25 mmol/animal) reduces thyroid radioiodide uptake in rats.{52323} Dietary administration of tropolone induces growth retardation and hyperactivity in mice.
Brand:CaymanSKU:29674 - 5 mgAvailable on backorder
Trospium is an antagonist of muscarinic (M) receptors (Kis = 0.50-2.3 nM for human M1-5 recombinant receptors, respectively).{28353} Formulations containing antimuscarinics, including trospium, are used to manage overactive bladder by relieving urgency, frequency, and incontinence.{28353,22773,33470}
Brand:CaymanSKU:21279 -Out of stock
Trospium is an antagonist of muscarinic (M) receptors (Kis = 0.50-2.3 nM for human M1-5 recombinant receptors, respectively).{28353} Formulations containing antimuscarinics, including trospium, are used to manage overactive bladder by relieving urgency, frequency, and incontinence.{28353,22773,33470}
Brand:CaymanSKU:21279 -Out of stock
Trospium is an antagonist of muscarinic (M) receptors (Kis = 0.50-2.3 nM for human M1-5 recombinant receptors, respectively).{28353} Formulations containing antimuscarinics, including trospium, are used to manage overactive bladder by relieving urgency, frequency, and incontinence.{28353,22773,33470}
Brand:CaymanSKU:21279 -Out of stock
Trospium is an antagonist of muscarinic (M) receptors (Kis = 0.50-2.3 nM for human M1-5 recombinant receptors, respectively).{28353} Formulations containing antimuscarinics, including trospium, are used to manage overactive bladder by relieving urgency, frequency, and incontinence.{28353,22773,33470}
Brand:CaymanSKU:21279 -Out of stock
Trovafloxacin is a broad spectrum antibiotic that inhibits the uncoiling of supercoiled DNA in bacteria by blocking the activity of topoisomerase IV (IC50 = 3.02 µg/ml) and DNA gyrase (IC50 = 7.13 µg/ml).{27493}
Brand:CaymanSKU:9000303 - 10 mgAvailable on backorder
Trovafloxacin is a broad spectrum antibiotic that inhibits the uncoiling of supercoiled DNA in bacteria by blocking the activity of topoisomerase IV (IC50 = 3.02 µg/ml) and DNA gyrase (IC50 = 7.13 µg/ml).{27493}
Brand:CaymanSKU:9000303 - 5 mgAvailable on backorder
Trovafloxacin is a broad spectrum antibiotic that inhibits the uncoiling of supercoiled DNA in bacteria by blocking the activity of topoisomerase IV (IC50 = 3.02 µg/ml) and DNA gyrase (IC50 = 7.13 µg/ml).{27493}
Brand:CaymanSKU:9000303 - 50 mgAvailable on backorder
Troxerutin is a flavonoid that has been found in a variety of fruits and vegetables and has diverse biological activities.{48639,48640,48641} It reduces D-galactose-induced increases in renal malondialdehyde (MDA) levels and decreases in renal Cu/Zn superoxide dismutase (SOD), catalase, and glutathione peroxidase (GPX) activities in mice when administered at a dose of 150 mg/kg per day, as well as attenuates D-galactose-induced increases in renal levels of NF-κB p65, inducible nitric oxide synthase (iNOS), COX-2, and prostaglandin E2 receptor 2 (EP2).{48639} Troxerutin (150 mg/kg per day) reduces blood glucose levels, plasma triglyceride levels, heart rate, and blood pressure in a rat model of type 2 diabetes induced by streptozotocin (STZ; Item No. 13104).{48640} Troxerutin (150 mg/kg per day) prevents the loss of dopaminergic neurons in the substantia nigra pars compacta (SNC) and reduces apomorphine-induced contralateral rotations in a rat model of Parkinson’s disease induced by 6-OHDA (Item No. 25330).{48641}
Brand:CaymanSKU:27220 - 10 gAvailable on backorder
Troxerutin is a flavonoid that has been found in a variety of fruits and vegetables and has diverse biological activities.{48639,48640,48641} It reduces D-galactose-induced increases in renal malondialdehyde (MDA) levels and decreases in renal Cu/Zn superoxide dismutase (SOD), catalase, and glutathione peroxidase (GPX) activities in mice when administered at a dose of 150 mg/kg per day, as well as attenuates D-galactose-induced increases in renal levels of NF-κB p65, inducible nitric oxide synthase (iNOS), COX-2, and prostaglandin E2 receptor 2 (EP2).{48639} Troxerutin (150 mg/kg per day) reduces blood glucose levels, plasma triglyceride levels, heart rate, and blood pressure in a rat model of type 2 diabetes induced by streptozotocin (STZ; Item No. 13104).{48640} Troxerutin (150 mg/kg per day) prevents the loss of dopaminergic neurons in the substantia nigra pars compacta (SNC) and reduces apomorphine-induced contralateral rotations in a rat model of Parkinson’s disease induced by 6-OHDA (Item No. 25330).{48641}
Brand:CaymanSKU:27220 - 100 gAvailable on backorder
Troxerutin is a flavonoid that has been found in a variety of fruits and vegetables and has diverse biological activities.{48639,48640,48641} It reduces D-galactose-induced increases in renal malondialdehyde (MDA) levels and decreases in renal Cu/Zn superoxide dismutase (SOD), catalase, and glutathione peroxidase (GPX) activities in mice when administered at a dose of 150 mg/kg per day, as well as attenuates D-galactose-induced increases in renal levels of NF-κB p65, inducible nitric oxide synthase (iNOS), COX-2, and prostaglandin E2 receptor 2 (EP2).{48639} Troxerutin (150 mg/kg per day) reduces blood glucose levels, plasma triglyceride levels, heart rate, and blood pressure in a rat model of type 2 diabetes induced by streptozotocin (STZ; Item No. 13104).{48640} Troxerutin (150 mg/kg per day) prevents the loss of dopaminergic neurons in the substantia nigra pars compacta (SNC) and reduces apomorphine-induced contralateral rotations in a rat model of Parkinson’s disease induced by 6-OHDA (Item No. 25330).{48641}
Brand:CaymanSKU:27220 - 25 gAvailable on backorder
Troxerutin is a flavonoid that has been found in a variety of fruits and vegetables and has diverse biological activities.{48639,48640,48641} It reduces D-galactose-induced increases in renal malondialdehyde (MDA) levels and decreases in renal Cu/Zn superoxide dismutase (SOD), catalase, and glutathione peroxidase (GPX) activities in mice when administered at a dose of 150 mg/kg per day, as well as attenuates D-galactose-induced increases in renal levels of NF-κB p65, inducible nitric oxide synthase (iNOS), COX-2, and prostaglandin E2 receptor 2 (EP2).{48639} Troxerutin (150 mg/kg per day) reduces blood glucose levels, plasma triglyceride levels, heart rate, and blood pressure in a rat model of type 2 diabetes induced by streptozotocin (STZ; Item No. 13104).{48640} Troxerutin (150 mg/kg per day) prevents the loss of dopaminergic neurons in the substantia nigra pars compacta (SNC) and reduces apomorphine-induced contralateral rotations in a rat model of Parkinson’s disease induced by 6-OHDA (Item No. 25330).{48641}
Brand:CaymanSKU:27220 - 5 gAvailable on backorder
Troxipide is an antiulcerative agent.{53962} It inhibits production of superoxide induced by N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP; Item No. 21495) in, and IL-8-induced migration of, isolated human polymorphonuclear (PMN) neutrophils when used at a concentration of 1 mM.{53963} Troxipide (100 and 200 mg/kg, i.p.) reduces the lesion size of gastric ulcers induced by diclofenac (Item Nos. 70680 | 22983) in rats.{53964}
Brand:CaymanSKU:30616 - 1 gAvailable on backorder
Troxipide is an antiulcerative agent.{53962} It inhibits production of superoxide induced by N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP; Item No. 21495) in, and IL-8-induced migration of, isolated human polymorphonuclear (PMN) neutrophils when used at a concentration of 1 mM.{53963} Troxipide (100 and 200 mg/kg, i.p.) reduces the lesion size of gastric ulcers induced by diclofenac (Item Nos. 70680 | 22983) in rats.{53964}
Brand:CaymanSKU:30616 - 5 gAvailable on backorder
Troxipide is an antiulcerative agent.{53962} It inhibits production of superoxide induced by N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP; Item No. 21495) in, and IL-8-induced migration of, isolated human polymorphonuclear (PMN) neutrophils when used at a concentration of 1 mM.{53963} Troxipide (100 and 200 mg/kg, i.p.) reduces the lesion size of gastric ulcers induced by diclofenac (Item Nos. 70680 | 22983) in rats.{53964}
Brand:CaymanSKU:30616 - 500 mgAvailable on backorder
Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient.{17533} They are present in the membranes that surround all biological cells and their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces. There are a few main classifications of gated ion channels. There are voltage-gated ion channels, ligand-gated, other gating systems, and finally those that are classified differently, having more exotic characteristics. The first are voltage-gated ion channels which open and close in response to membrane potential. These are then seperated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels, each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inward-rectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels, and cyclic nucleotide-gated channels. Finally, the other classifications are based on less normal characteristics such as two-pore channels and transient receptor potential channels.{17535} Transient receptor potential cation channel, subfamily C, member 4 (TRPC4), is a human gene encoding a protein of the same name. They are expressed in smooth muscle and endothelial cells where they regulate membrane potential and calcium influx. TRPC4 is activated by G(q)/phospholipase C-coupled receptors, but the underlying mechanism remains elusive.{17697} Studies suggest TRPC4 contributes to axonal regeneration after nerve injury.{17698}
Brand:CaymanSKU:13719 - 100 µgAvailable on backorder
Antigen: rat TRPC4 amino acids 930-947 • Isotype: IgG2b • Host: mouse, clone S77-15 • Cross Reactivity: (+) human, mouse, and rat TRPC4 • Application(s): ICC, IP, and WB • TRPC4 is expressed in smooth muscle and endothelial cells where it regulates membrane potential and calcium influx. TRPC4 is activated by G(q)/phospholipase C-coupled receptors.
Brand:CaymanSKU:13719- 100 µgAvailable on backorder
Antigen: rat TRPC4 amino acids 930-947 • Isotype: IgG2b • Host: mouse, clone S77-15 • Cross Reactivity: (+) human, mouse, and rat TRPC4 • Application(s): ICC, IP, and WB • TRPC4 is expressed in smooth muscle and endothelial cells where it regulates membrane potential and calcium influx. TRPC4 is activated by G(q)/phospholipase C-coupled receptors.
Brand:CaymanSKU:13719- 100 µg