Cayman
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Triacetylphloroglucinol is a C3-symmetric tritopic bridging ligand.{51112,51113,51114} It has been used in the synthesis of various compounds, including trinuclear vanadium Schiff base complexes, copper complexes, and anthelmintics.
Brand:CaymanSKU:27073 - 100 mgAvailable on backorder
Triacetylphloroglucinol is a C3-symmetric tritopic bridging ligand.{51112,51113,51114} It has been used in the synthesis of various compounds, including trinuclear vanadium Schiff base complexes, copper complexes, and anthelmintics.
Brand:CaymanSKU:27073 - 250 mgAvailable on backorder
Triacetylphloroglucinol is a C3-symmetric tritopic bridging ligand.{51112,51113,51114} It has been used in the synthesis of various compounds, including trinuclear vanadium Schiff base complexes, copper complexes, and anthelmintics.
Brand:CaymanSKU:27073 - 50 mgAvailable on backorder
Triacontanoic acid methyl ester is a fatty acid methyl ester that has been found in sediment samples from the Harney River in Florida and Lake Kivu in the East African rift valley.{38856,38863} [Matreya, LLC. Catalog No. 1273]
Brand:CaymanSKU:26727 - 10 mgAvailable on backorder
Triacontanoic acid methyl ester is a fatty acid methyl ester that has been found in sediment samples from the Harney River in Florida and Lake Kivu in the East African rift valley.{38856,38863} [Matreya, LLC. Catalog No. 1273]
Brand:CaymanSKU:26727 - 25 mgAvailable on backorder
Triacontanoic acid methyl ester is a fatty acid methyl ester that has been found in sediment samples from the Harney River in Florida and Lake Kivu in the East African rift valley.{38856,38863} [Matreya, LLC. Catalog No. 1273]
Brand:CaymanSKU:26727 - 50 mgAvailable on backorder
Triacsin C, originally isolated from Streptomyces sp., is an inhibitor of long fatty acid acyl-CoA synthetase (IC50 = 6.3 μM in Raji cells).{1627} It has been shown to interfere with lipid metabolism by inhibiting the de novo synthesis of triglycerides, diglycerides, and cholesterol esters.{25053} It is also known to act as a hypotensive vasodilator, modulating endothelial nitric oxide synthase repalmitoylation by limiting palmitoyl CoA availability.{25054} Triacsin C can inhibit pancreatic β-cell function by suppressing the mobilization of intracellular calcium.{25055}
Brand:CaymanSKU:10007448 - 1 mgAvailable on backorder
Triacsin C, originally isolated from Streptomyces sp., is an inhibitor of long fatty acid acyl-CoA synthetase (IC50 = 6.3 μM in Raji cells).{1627} It has been shown to interfere with lipid metabolism by inhibiting the de novo synthesis of triglycerides, diglycerides, and cholesterol esters.{25053} It is also known to act as a hypotensive vasodilator, modulating endothelial nitric oxide synthase repalmitoylation by limiting palmitoyl CoA availability.{25054} Triacsin C can inhibit pancreatic β-cell function by suppressing the mobilization of intracellular calcium.{25055}
Brand:CaymanSKU:10007448 - 500 µgAvailable on backorder
Triadimefon is a triazole fungicide used to control powdery mildew, rusts, and other fungal pests on grains, fruit and vegetable crops, turf, shrubs, and trees.{30322} It inhibits lanosterol 14α-demethylase, interfering with oxidative demethylation reactions in the ergosterol biosynthesis pathway of fungi, and also blocks gibberellin biosynthesis.{30322}
Brand:CaymanSKU:-Available on backorder
Triadimefon is a triazole fungicide used to control powdery mildew, rusts, and other fungal pests on grains, fruit and vegetable crops, turf, shrubs, and trees.{30322} It inhibits lanosterol 14α-demethylase, interfering with oxidative demethylation reactions in the ergosterol biosynthesis pathway of fungi, and also blocks gibberellin biosynthesis.{30322}
Brand:CaymanSKU:-Available on backorder
Triadimefon is a triazole fungicide used to control powdery mildew, rusts, and other fungal pests on grains, fruit and vegetable crops, turf, shrubs, and trees.{30322} It inhibits lanosterol 14α-demethylase, interfering with oxidative demethylation reactions in the ergosterol biosynthesis pathway of fungi, and also blocks gibberellin biosynthesis.{30322}
Brand:CaymanSKU:-Available on backorder
Triadimenol is a metabolite of triadimefon (Item No. 18714), a broad-spectrum chiral triazole fungicide, that is formed by reduction of a carbonyl group to the corresponding alcohol.{42231} It is teratogenic, inducing cranial nerve and ganglia abnormalities in a rat post-implantation whole embryo culture model when used at concentrations ranging from 12.5 to 125 μM.{42232} In vivo, triadimenol induces embryotoxicity in rats and rabbits when administered orally at doses of 100 and 40 mg/kg, respectively. Embryonic exposure to triadimenol (3-3,000 μg/L) induces embryonic mortality as well as decreases fertility and increases the number of female offspring in medaka fish (O. latipes).{42233}
Brand:CaymanSKU:24216 - 250 mgAvailable on backorder
Triadimenol is a metabolite of triadimefon (Item No. 18714), a broad-spectrum chiral triazole fungicide, that is formed by reduction of a carbonyl group to the corresponding alcohol.{42231} It is teratogenic, inducing cranial nerve and ganglia abnormalities in a rat post-implantation whole embryo culture model when used at concentrations ranging from 12.5 to 125 μM.{42232} In vivo, triadimenol induces embryotoxicity in rats and rabbits when administered orally at doses of 100 and 40 mg/kg, respectively. Embryonic exposure to triadimenol (3-3,000 μg/L) induces embryonic mortality as well as decreases fertility and increases the number of female offspring in medaka fish (O. latipes).{42233}
Brand:CaymanSKU:24216 - 500 mgAvailable on backorder
Triamcinolone is a synthetic glucocorticoid.{45390,45393} It increases expression of the calcitonin receptor in murine osteoclast-like cells when used at a concentration of 1 μM.{45391} Triamcinolone (3 mg/kg, s.c.) reduces heat hyperalgesia and mechano-allodynia and decreases the number of TNF-α-positive mast cells in injured sciatic nerve in a rat model of chronic constriction injury-induced neuropathic pain.{45390} It also reduces levels of the glycosaminoglycans hyaluronic acid and chondroitin-4-sulfate in human keloid implants in athymic nude mice.{45392}
Brand:CaymanSKU:28275 - 100 mgAvailable on backorder
Triamcinolone is a synthetic glucocorticoid.{45390,45393} It increases expression of the calcitonin receptor in murine osteoclast-like cells when used at a concentration of 1 μM.{45391} Triamcinolone (3 mg/kg, s.c.) reduces heat hyperalgesia and mechano-allodynia and decreases the number of TNF-α-positive mast cells in injured sciatic nerve in a rat model of chronic constriction injury-induced neuropathic pain.{45390} It also reduces levels of the glycosaminoglycans hyaluronic acid and chondroitin-4-sulfate in human keloid implants in athymic nude mice.{45392}
Brand:CaymanSKU:28275 - 250 mgAvailable on backorder
Triamcinolone is a synthetic glucocorticoid.{45390,45393} It increases expression of the calcitonin receptor in murine osteoclast-like cells when used at a concentration of 1 μM.{45391} Triamcinolone (3 mg/kg, s.c.) reduces heat hyperalgesia and mechano-allodynia and decreases the number of TNF-α-positive mast cells in injured sciatic nerve in a rat model of chronic constriction injury-induced neuropathic pain.{45390} It also reduces levels of the glycosaminoglycans hyaluronic acid and chondroitin-4-sulfate in human keloid implants in athymic nude mice.{45392}
Brand:CaymanSKU:28275 - 50 mgAvailable on backorder
Triamcinolone is a synthetic glucocorticoid.{45390,45393} It increases expression of the calcitonin receptor in murine osteoclast-like cells when used at a concentration of 1 μM.{45391} Triamcinolone (3 mg/kg, s.c.) reduces heat hyperalgesia and mechano-allodynia and decreases the number of TNF-α-positive mast cells in injured sciatic nerve in a rat model of chronic constriction injury-induced neuropathic pain.{45390} It also reduces levels of the glycosaminoglycans hyaluronic acid and chondroitin-4-sulfate in human keloid implants in athymic nude mice.{45392}
Brand:CaymanSKU:28275 - 500 mgAvailable on backorder
Triamcinolone acetonide is a synthetic corticosteroid.{43074} It decreases cytokine levels, the firing rate of sensory neurons, and mechanical hypersensitivity in a rat spinal nerve ligation model when used at a dose of 1.5 mg/kg prior to and following surgery for three days. Triamcinolone acetonide also decreases outflow facility in a mouse model of steroid-induced glaucoma when 20 µl of a 40 mg/ml suspension is administered subconjunctivally.{43075} Formulations containing triamcinolone acetonide are used in the treatment of diabetic macular edema.
Brand:CaymanSKU:-Available on backorder
Triamcinolone acetonide is a synthetic corticosteroid.{43074} It decreases cytokine levels, the firing rate of sensory neurons, and mechanical hypersensitivity in a rat spinal nerve ligation model when used at a dose of 1.5 mg/kg prior to and following surgery for three days. Triamcinolone acetonide also decreases outflow facility in a mouse model of steroid-induced glaucoma when 20 µl of a 40 mg/ml suspension is administered subconjunctivally.{43075} Formulations containing triamcinolone acetonide are used in the treatment of diabetic macular edema.
Brand:CaymanSKU:-Available on backorder
Triamcinolone acetonide is a synthetic corticosteroid.{43074} It decreases cytokine levels, the firing rate of sensory neurons, and mechanical hypersensitivity in a rat spinal nerve ligation model when used at a dose of 1.5 mg/kg prior to and following surgery for three days. Triamcinolone acetonide also decreases outflow facility in a mouse model of steroid-induced glaucoma when 20 µl of a 40 mg/ml suspension is administered subconjunctivally.{43075} Formulations containing triamcinolone acetonide are used in the treatment of diabetic macular edema.
Brand:CaymanSKU:-Available on backorder
Triamcinolone acetonide is a synthetic corticosteroid.{43074} It decreases cytokine levels, the firing rate of sensory neurons, and mechanical hypersensitivity in a rat spinal nerve ligation model when used at a dose of 1.5 mg/kg prior to and following surgery for three days. Triamcinolone acetonide also decreases outflow facility in a mouse model of steroid-induced glaucoma when 20 µl of a 40 mg/ml suspension is administered subconjunctivally.{43075} Formulations containing triamcinolone acetonide are used in the treatment of diabetic macular edema.
Brand:CaymanSKU:-Available on backorder
Triamterene is an inhibitor of the epithelial sodium channel ENaC that increases renal sodium excretion and decreases potassium excretion. It inhibits rat ENaC with an IC50 value of 4.5 µM.{33172} Diuretics, including triamterene, have been abused as performance-enhancing drugs and masking agents in sports doping.{33139}
Brand:CaymanSKU:21242 -Out of stock
Triamterene (Item No. 22486) is an analytical reference standard that is categorized as a pteridine. Triamterene is an inhibitor of the epithelial sodium channel (ENaC) that increases renal sodium excretion and decreases potassium excretion. It inhibits rat ENaC with an IC50 value of 4.5 µM.{33172} Diuretics, including triamterene, have been abused as performance-enhancing drugs and masking agents in sports doping.{33139} This product is intended for research and forensic applications.
Brand:CaymanSKU:22486 -Out of stock
Triamterene is an inhibitor of the epithelial sodium channel ENaC that increases renal sodium excretion and decreases potassium excretion. It inhibits rat ENaC with an IC50 value of 4.5 µM.{33172} Diuretics, including triamterene, have been abused as performance-enhancing drugs and masking agents in sports doping.{33139}
Brand:CaymanSKU:21242 -Out of stock
Triamterene (Item No. 22486) is an analytical reference standard that is categorized as a pteridine. Triamterene is an inhibitor of the epithelial sodium channel (ENaC) that increases renal sodium excretion and decreases potassium excretion. It inhibits rat ENaC with an IC50 value of 4.5 µM.{33172} Diuretics, including triamterene, have been abused as performance-enhancing drugs and masking agents in sports doping.{33139} This product is intended for research and forensic applications.
Brand:CaymanSKU:22486 -Out of stock
Trichlormethiazide is a thiazide diuretic.{49458} It inhibits sodium and chloride ion flux in the connecting tubule, but not the cortical collecting duct or the distal convoluted tubule, in isolated rabbit kidney tubules when used at a concentration of 1 mM. Trichlormethiazide increases relaxation induced by acetylcholine (Item No. 23829) in norepinephrine-precontracted mesenteric arterial rings isolated from spontaneously hypertensive rats (EC50 = 33 nM).{49459} It increases urine output and urinary excretion of sodium, potassium, and chloride ions in dogs in a dose-dependent manner.{49461} It reduces systolic blood pressure in spontaneously hypertensive, but not normotensive, rats when administered at doses of 10 and 30 mg/kg.{49461} Formulations containing trichlormethiazide have been used in the treatment of edema and hypertension.
Brand:CaymanSKU:29331 - 1 gAvailable on backorder
Trichlormethiazide is a thiazide diuretic.{49458} It inhibits sodium and chloride ion flux in the connecting tubule, but not the cortical collecting duct or the distal convoluted tubule, in isolated rabbit kidney tubules when used at a concentration of 1 mM. Trichlormethiazide increases relaxation induced by acetylcholine (Item No. 23829) in norepinephrine-precontracted mesenteric arterial rings isolated from spontaneously hypertensive rats (EC50 = 33 nM).{49459} It increases urine output and urinary excretion of sodium, potassium, and chloride ions in dogs in a dose-dependent manner.{49461} It reduces systolic blood pressure in spontaneously hypertensive, but not normotensive, rats when administered at doses of 10 and 30 mg/kg.{49461} Formulations containing trichlormethiazide have been used in the treatment of edema and hypertension.
Brand:CaymanSKU:29331 - 10 gAvailable on backorder
Trichlormethiazide is a thiazide diuretic.{49458} It inhibits sodium and chloride ion flux in the connecting tubule, but not the cortical collecting duct or the distal convoluted tubule, in isolated rabbit kidney tubules when used at a concentration of 1 mM. Trichlormethiazide increases relaxation induced by acetylcholine (Item No. 23829) in norepinephrine-precontracted mesenteric arterial rings isolated from spontaneously hypertensive rats (EC50 = 33 nM).{49459} It increases urine output and urinary excretion of sodium, potassium, and chloride ions in dogs in a dose-dependent manner.{49461} It reduces systolic blood pressure in spontaneously hypertensive, but not normotensive, rats when administered at doses of 10 and 30 mg/kg.{49461} Formulations containing trichlormethiazide have been used in the treatment of edema and hypertension.
Brand:CaymanSKU:29331 - 5 gAvailable on backorder
Trichostatin A is a potent, reversible inhibitor of class I, II, and IV histone deacetylases (HDACs). In human Jurkat T cells, trichostatin A arrests cell cycle progression in G1 and inhibits the activity of HDAC1 with an IC50 value of 70 nM.{8150} Trichostatin A selectively inhibits the removal of acetyl groups from the amino-terminal lysine residues of core histones, which modulates the access of transcription factors to the underlying genomic DNA.{4011}
Brand:CaymanSKU:89730 - 1 mgAvailable on backorder
Trichostatin A is a potent, reversible inhibitor of class I, II, and IV histone deacetylases (HDACs). In human Jurkat T cells, trichostatin A arrests cell cycle progression in G1 and inhibits the activity of HDAC1 with an IC50 value of 70 nM.{8150} Trichostatin A selectively inhibits the removal of acetyl groups from the amino-terminal lysine residues of core histones, which modulates the access of transcription factors to the underlying genomic DNA.{4011}
Brand:CaymanSKU:89730 - 10 mgAvailable on backorder
Trichostatin A is a potent, reversible inhibitor of class I, II, and IV histone deacetylases (HDACs). In human Jurkat T cells, trichostatin A arrests cell cycle progression in G1 and inhibits the activity of HDAC1 with an IC50 value of 70 nM.{8150} Trichostatin A selectively inhibits the removal of acetyl groups from the amino-terminal lysine residues of core histones, which modulates the access of transcription factors to the underlying genomic DNA.{4011}
Brand:CaymanSKU:89730 - 5 mgAvailable on backorder
Trichostatin A is a potent, reversible inhibitor of class I, II, and IV histone deacetylases (HDACs). In human Jurkat T cells, trichostatin A arrests cell cycle progression in G1 and inhibits the activity of HDAC1 with an IC50 value of 70 nM.{8150} Trichostatin A selectively inhibits the removal of acetyl groups from the amino-terminal lysine residues of core histones, which modulates the access of transcription factors to the underlying genomic DNA.{4011}
Brand:CaymanSKU:89730 - 500 µgAvailable on backorder
Trichostatin C is a glycosylated derivative of trichostatin A (Item No. 89730), the antifungal antibiotic that reversibly inhibits histone deacetylase.{4293} Trichostatin C is reported to be the first example of a glucopyranosyl hydroxamate identified in nature.{31856} It has been shown to induce the differentiation of a mouse erythroleukemia cell line and to increase histone H4 acetylation in B cells, though at higher concentrations than trichostatin A.{31857,31855}
Brand:CaymanSKU:20220 -Available on backorder
Trichostatin C is a glycosylated derivative of trichostatin A (Item No. 89730), the antifungal antibiotic that reversibly inhibits histone deacetylase.{4293} Trichostatin C is reported to be the first example of a glucopyranosyl hydroxamate identified in nature.{31856} It has been shown to induce the differentiation of a mouse erythroleukemia cell line and to increase histone H4 acetylation in B cells, though at higher concentrations than trichostatin A.{31857,31855}
Brand:CaymanSKU:20220 -Available on backorder
Brand:CaymanSKU:28134 - 1 mgAvailable on backorder
Akt-1, -2, and -3 are serine/threonine protein kinases in the phosphatidylinositol 3 (PI3)-kinase signalling pathway that play a critical role in the regulation of cell proliferation and survival.{12235,13740} Following recruitment of Akt to the plasma membrane, phosphorylation at threonine 308 and serine 473 (Akt-1 numbering) by phosphoinositide-dependent kinases (PDK) 1 and 2 results in full activation of the enzyme. Triciribine is a cell-permeable tricyclic nucleoside that inhibits the phosphorylation, activation, and signalling of Akt-1, -2, and -3.{15002} It does not inhibit phosphatidylinositol 3 (PI3)-Kinase or PDK1, the direct upstream activators of Akt, nor does it inhibit PKC, PKA, ERK1/2, serum- and glucocorticoid-inducible kinase, p38, STAT3, or JNK signalling pathways.{15002} Triciribine effectively inhibits growth of Akt-overexpressing human cancer cell lines in vitro with 50% inhibition at ~5-10 µM. It also inhibit growth of tumor xenografts in mice by greater than 80% at a dose of 1 mg/kg/day.{15002,15003}
Brand:CaymanSKU:10010237 - 1 mgAvailable on backorder
Akt-1, -2, and -3 are serine/threonine protein kinases in the phosphatidylinositol 3 (PI3)-kinase signalling pathway that play a critical role in the regulation of cell proliferation and survival.{12235,13740} Following recruitment of Akt to the plasma membrane, phosphorylation at threonine 308 and serine 473 (Akt-1 numbering) by phosphoinositide-dependent kinases (PDK) 1 and 2 results in full activation of the enzyme. Triciribine is a cell-permeable tricyclic nucleoside that inhibits the phosphorylation, activation, and signalling of Akt-1, -2, and -3.{15002} It does not inhibit phosphatidylinositol 3 (PI3)-Kinase or PDK1, the direct upstream activators of Akt, nor does it inhibit PKC, PKA, ERK1/2, serum- and glucocorticoid-inducible kinase, p38, STAT3, or JNK signalling pathways.{15002} Triciribine effectively inhibits growth of Akt-overexpressing human cancer cell lines in vitro with 50% inhibition at ~5-10 µM. It also inhibit growth of tumor xenografts in mice by greater than 80% at a dose of 1 mg/kg/day.{15002,15003}
Brand:CaymanSKU:- Akt-1, -2, and -3 are serine/threonine protein kinases in the phosphatidylinositol 3 (PI3)-kinase signalling pathway that play a critical role in the regulation of cell proliferation and survival.{12235,13740} Following recruitment of Akt to the plasma membrane, phosphorylation at threonine 308 and serine 473 (Akt-1 numbering) by phosphoinositide-dependent kinases (PDK) 1 and 2 results in full activation of the enzyme. Triciribine is a cell-permeable tricyclic nucleoside that inhibits the phosphorylation, activation, and signalling of Akt-1, -2, and -3.{15002} It does not inhibit phosphatidylinositol 3 (PI3)-Kinase or PDK1, the direct upstream activators of Akt, nor does it inhibit PKC, PKA, ERK1/2, serum- and glucocorticoid-inducible kinase, p38, STAT3, or JNK signalling pathways.{15002} Triciribine effectively inhibits growth of Akt-overexpressing human cancer cell lines in vitro with 50% inhibition at ~5-10 µM. It also inhibit growth of tumor xenografts in mice by greater than 80% at a dose of 1 mg/kg/day.{15002,15003}
Brand:CaymanSKU:10010237 - 10 mgAvailable on backorder
Akt-1, -2, and -3 are serine/threonine protein kinases in the phosphatidylinositol 3 (PI3)-kinase signalling pathway that play a critical role in the regulation of cell proliferation and survival.{12235,13740} Following recruitment of Akt to the plasma membrane, phosphorylation at threonine 308 and serine 473 (Akt-1 numbering) by phosphoinositide-dependent kinases (PDK) 1 and 2 results in full activation of the enzyme. Triciribine is a cell-permeable tricyclic nucleoside that inhibits the phosphorylation, activation, and signalling of Akt-1, -2, and -3.{15002} It does not inhibit phosphatidylinositol 3 (PI3)-Kinase or PDK1, the direct upstream activators of Akt, nor does it inhibit PKC, PKA, ERK1/2, serum- and glucocorticoid-inducible kinase, p38, STAT3, or JNK signalling pathways.{15002} Triciribine effectively inhibits growth of Akt-overexpressing human cancer cell lines in vitro with 50% inhibition at ~5-10 µM. It also inhibit growth of tumor xenografts in mice by greater than 80% at a dose of 1 mg/kg/day.{15002,15003}
Brand:CaymanSKU:- Akt-1, -2, and -3 are serine/threonine protein kinases in the phosphatidylinositol 3 (PI3)-kinase signalling pathway that play a critical role in the regulation of cell proliferation and survival.{12235,13740} Following recruitment of Akt to the plasma membrane, phosphorylation at threonine 308 and serine 473 (Akt-1 numbering) by phosphoinositide-dependent kinases (PDK) 1 and 2 results in full activation of the enzyme. Triciribine is a cell-permeable tricyclic nucleoside that inhibits the phosphorylation, activation, and signalling of Akt-1, -2, and -3.{15002} It does not inhibit phosphatidylinositol 3 (PI3)-Kinase or PDK1, the direct upstream activators of Akt, nor does it inhibit PKC, PKA, ERK1/2, serum- and glucocorticoid-inducible kinase, p38, STAT3, or JNK signalling pathways.{15002} Triciribine effectively inhibits growth of Akt-overexpressing human cancer cell lines in vitro with 50% inhibition at ~5-10 µM. It also inhibit growth of tumor xenografts in mice by greater than 80% at a dose of 1 mg/kg/day.{15002,15003}
Brand:CaymanSKU:10010237 - 5 mgAvailable on backorder
Triclabendazole is a member of the benzimidazole family of anthelmintics. It is effective against F. hepatica helminths that cause fascioliasis, reducing secreted protease enzyme activities that are critical for the invasion, migration, nutrition, and survival of the parasite.{30605} In yeast and mammalian cells, triclabendazole was shown to inhibit adenylyl cyclase in the Ras-adenylyl cyclase-protein kinase A nutrient-sensing pathway and to prevent apoptosis induced by the Parkinson’s disease-related protein α-synuclein, demonstrating a protective role during various cellular stresses.{30603,30604}
Brand:CaymanSKU:-Available on backorder
Triclabendazole is a member of the benzimidazole family of anthelmintics. It is effective against F. hepatica helminths that cause fascioliasis, reducing secreted protease enzyme activities that are critical for the invasion, migration, nutrition, and survival of the parasite.{30605} In yeast and mammalian cells, triclabendazole was shown to inhibit adenylyl cyclase in the Ras-adenylyl cyclase-protein kinase A nutrient-sensing pathway and to prevent apoptosis induced by the Parkinson’s disease-related protein α-synuclein, demonstrating a protective role during various cellular stresses.{30603,30604}
Brand:CaymanSKU:-Available on backorder
Triclabendazole is a member of the benzimidazole family of anthelmintics. It is effective against F. hepatica helminths that cause fascioliasis, reducing secreted protease enzyme activities that are critical for the invasion, migration, nutrition, and survival of the parasite.{30605} In yeast and mammalian cells, triclabendazole was shown to inhibit adenylyl cyclase in the Ras-adenylyl cyclase-protein kinase A nutrient-sensing pathway and to prevent apoptosis induced by the Parkinson’s disease-related protein α-synuclein, demonstrating a protective role during various cellular stresses.{30603,30604}
Brand:CaymanSKU:-Available on backorder
Triclabendazole is a member of the benzimidazole family of anthelmintics. It is effective against F. hepatica helminths that cause fascioliasis, reducing secreted protease enzyme activities that are critical for the invasion, migration, nutrition, and survival of the parasite.{30605} In yeast and mammalian cells, triclabendazole was shown to inhibit adenylyl cyclase in the Ras-adenylyl cyclase-protein kinase A nutrient-sensing pathway and to prevent apoptosis induced by the Parkinson’s disease-related protein α-synuclein, demonstrating a protective role during various cellular stresses.{30603,30604}
Brand:CaymanSKU:-Available on backorder
Triclosan is a broad-spectrum antibacterial agent that inhibits bacterial fatty acid synthesis.{7253,25140} It is effective against Gram-negative and Gram-positive bacteria, as well as against Mycobacteria.{32293,32294} Triclosan is used in a variety of products, including antiseptic soaps, deodorants, and hand washes.{32293,32294}
Brand:CaymanSKU:20342 -Available on backorder
Triclosan is a broad-spectrum antibacterial agent that inhibits bacterial fatty acid synthesis.{7253,25140} It is effective against Gram-negative and Gram-positive bacteria, as well as against Mycobacteria.{32293,32294} Triclosan is used in a variety of products, including antiseptic soaps, deodorants, and hand washes.{32293,32294}
Brand:CaymanSKU:20342 -Available on backorder
Triclosan is a broad-spectrum antibacterial agent that inhibits bacterial fatty acid synthesis.{7253,25140} It is effective against Gram-negative and Gram-positive bacteria, as well as against Mycobacteria.{32293,32294} Triclosan is used in a variety of products, including antiseptic soaps, deodorants, and hand washes.{32293,32294}
Brand:CaymanSKU:20342 -Available on backorder
Tricosanoic acid is a naturally occurring saturated fatty acid that has been found in various edible mushroom species.{49092} It inhibits lysis of human erythrocytes induced by S. aureus delta toxin in a concentration-dependent manner.{14239} Tricosanoic acid levels are decreased in the sebum of patients with papulopustular rosacea and increased in malignant, but not adjacent nonmalignant, prostate tissue in patients with prostate cancer.{49093,38044} Tricosanoic acid has been used as an internal standard for the quantification of fatty acids in chicken egg yolk.{49094}
Brand:CaymanSKU:26867 - 100 mgAvailable on backorder
Tricosanoic acid is a naturally occurring saturated fatty acid that has been found in various edible mushroom species.{49092} It inhibits lysis of human erythrocytes induced by S. aureus delta toxin in a concentration-dependent manner.{14239} Tricosanoic acid levels are decreased in the sebum of patients with papulopustular rosacea and increased in malignant, but not adjacent nonmalignant, prostate tissue in patients with prostate cancer.{49093,38044} Tricosanoic acid has been used as an internal standard for the quantification of fatty acids in chicken egg yolk.{49094}
Brand:CaymanSKU:26867 - 25 mgAvailable on backorder
Tricosanoic acid is a naturally occurring saturated fatty acid that has been found in various edible mushroom species.{49092} It inhibits lysis of human erythrocytes induced by S. aureus delta toxin in a concentration-dependent manner.{14239} Tricosanoic acid levels are decreased in the sebum of patients with papulopustular rosacea and increased in malignant, but not adjacent nonmalignant, prostate tissue in patients with prostate cancer.{49093,38044} Tricosanoic acid has been used as an internal standard for the quantification of fatty acids in chicken egg yolk.{49094}
Brand:CaymanSKU:26867 - 250 mgAvailable on backorder
Tricosanoic acid is a naturally occurring saturated fatty acid that has been found in various edible mushroom species.{49092} It inhibits lysis of human erythrocytes induced by S. aureus delta toxin in a concentration-dependent manner.{14239} Tricosanoic acid levels are decreased in the sebum of patients with papulopustular rosacea and increased in malignant, but not adjacent nonmalignant, prostate tissue in patients with prostate cancer.{49093,38044} Tricosanoic acid has been used as an internal standard for the quantification of fatty acids in chicken egg yolk.{49094}
Brand:CaymanSKU:26867 - 50 mgAvailable on backorder
Tricosanoic acid methyl ester is an ester form of tricosanoic acid (Item No. 26867). It has been found in peanut butter and in latent fingerprint residue samples.{48209,48210}
Brand:CaymanSKU:26868 - 1 gAvailable on backorder
Tricosanoic acid methyl ester is an ester form of tricosanoic acid (Item No. 26867). It has been found in peanut butter and in latent fingerprint residue samples.{48209,48210}
Brand:CaymanSKU:26868 - 250 mgAvailable on backorder
Tricosanoic acid methyl ester is an ester form of tricosanoic acid (Item No. 26867). It has been found in peanut butter and in latent fingerprint residue samples.{48209,48210}
Brand:CaymanSKU:26868 - 500 mgAvailable on backorder
Tricosanoyl ethanolamide is a member of the family of fatty N-acyl ethanolamines collectively called endocannabinoids.{1202,1712,13153,22439} The relative importance of this ethanolamine metabolite has yet to be determined.
Brand:CaymanSKU:9001743 - 10 mgAvailable on backorder
Tricosanoyl ethanolamide is a member of the family of fatty N-acyl ethanolamines collectively called endocannabinoids.{1202,1712,13153,22439} The relative importance of this ethanolamine metabolite has yet to be determined.
Brand:CaymanSKU:9001743 - 5 mgAvailable on backorder
Tricosanoyl ethanolamide is a member of the family of fatty N-acyl ethanolamines collectively called endocannabinoids.{1202,1712,13153,22439} The relative importance of this ethanolamine metabolite has yet to be determined.
Brand:CaymanSKU:9001743 - 50 mgAvailable on backorder
Tridecanoic acid is a 13-carbon saturated fatty acid found in dairy products and also as a product of anaerobic biodegradation of n-hexadecane.{31493,31492} It has been identified as a substrate of phospholipase A2.{31494}
Brand:CaymanSKU:19725 -Available on backorder
Tridecanoic acid is a 13-carbon saturated fatty acid found in dairy products and also as a product of anaerobic biodegradation of n-hexadecane.{31493,31492} It has been identified as a substrate of phospholipase A2.{31494}
Brand:CaymanSKU:19725 -Available on backorder
Tridecanoic acid is a 13-carbon saturated fatty acid found in dairy products and also as a product of anaerobic biodegradation of n-hexadecane.{31493,31492} It has been identified as a substrate of phospholipase A2.{31494}
Brand:CaymanSKU:19725 -Available on backorder
Tridecanoic acid is a 13-carbon saturated fatty acid found in dairy products and also as a product of anaerobic biodegradation of n-hexadecane.{31493,31492} It has been identified as a substrate of phospholipase A2.{31494}
Brand:CaymanSKU:19725 -Available on backorder
Tridecanoic acid methyl ester is an esterified form of tridecanoic acid (Item No. 19725). It is a component of biodiesel generated from subcritical water-subcritical methanol (SCW-SCM) separation of sewage sludge.{48249}
Brand:CaymanSKU:26721 - 1 gAvailable on backorder
Tridecanoic acid methyl ester is an esterified form of tridecanoic acid (Item No. 19725). It is a component of biodiesel generated from subcritical water-subcritical methanol (SCW-SCM) separation of sewage sludge.{48249}
Brand:CaymanSKU:26721 - 10 gAvailable on backorder
Tridecanoic acid methyl ester is an esterified form of tridecanoic acid (Item No. 19725). It is a component of biodiesel generated from subcritical water-subcritical methanol (SCW-SCM) separation of sewage sludge.{48249}
Brand:CaymanSKU:26721 - 25 gAvailable on backorder
Tridecanoic acid methyl ester is an esterified form of tridecanoic acid (Item No. 19725). It is a component of biodiesel generated from subcritical water-subcritical methanol (SCW-SCM) separation of sewage sludge.{48249}
Brand:CaymanSKU:26721 - 5 gAvailable on backorder
Trientine is a polyamine chelating agent.{38494} It reduces the amount of a copper-albumin complex and increases formation of low molecular weight complexes in a dialysis assay in a concentration-dependent manner. Trientine mobilizes copper ex vivo in human sera, increasing the supernatant percentage in an analytical ultracentrifugation experiment. In vivo, trientine (40 mg/kg, i.v.) mobilizes copper in the kidneys, but not the liver, to increase urinary excretion in rats. Trientine also decreases nickel accumulation in the liver, kidney, and spleen in mice injected with nickel chloride.{38495} Formulations containing trientine have been used to reduce copper accumulation in patients with Wilson’s disease.
Brand:CaymanSKU:24000 - 1 gAvailable on backorder
Trientine is a polyamine chelating agent.{38494} It reduces the amount of a copper-albumin complex and increases formation of low molecular weight complexes in a dialysis assay in a concentration-dependent manner. Trientine mobilizes copper ex vivo in human sera, increasing the supernatant percentage in an analytical ultracentrifugation experiment. In vivo, trientine (40 mg/kg, i.v.) mobilizes copper in the kidneys, but not the liver, to increase urinary excretion in rats. Trientine also decreases nickel accumulation in the liver, kidney, and spleen in mice injected with nickel chloride.{38495} Formulations containing trientine have been used to reduce copper accumulation in patients with Wilson’s disease.
Brand:CaymanSKU:24000 - 250 mgAvailable on backorder
Trientine is a polyamine chelating agent.{38494} It reduces the amount of a copper-albumin complex and increases formation of low molecular weight complexes in a dialysis assay in a concentration-dependent manner. Trientine mobilizes copper ex vivo in human sera, increasing the supernatant percentage in an analytical ultracentrifugation experiment. In vivo, trientine (40 mg/kg, i.v.) mobilizes copper in the kidneys, but not the liver, to increase urinary excretion in rats. Trientine also decreases nickel accumulation in the liver, kidney, and spleen in mice injected with nickel chloride.{38495} Formulations containing trientine have been used to reduce copper accumulation in patients with Wilson’s disease.
Brand:CaymanSKU:24000 - 500 mgAvailable on backorder
Trifloxystrobin is a fungicide.{42423,42424} It inhibits the growth of R. solani isolates from sugar beet crops (EC50s = 0.14-823.54 μg/ml).{42423} Trifloxystrobin (100-1,000 ppm) inhibits mycelial growth of C. gloeosporioides when used in combination with tebuconazole (Item No. 24052).{42424} It is toxic to various aquatic species, including R. arenarum, P. santafecinus, E. bicolor, and L. latrans tadpoles (LC50s = 0.22, 0.14, 0.1, and 0.26 mg/L, respectively).{42425} It also reduces mobility of tadpoles and decreases predation of trifloxystrobin-exposed, but not non-exposed, tadpoles by eels.
Brand:CaymanSKU:25825 - 100 mgAvailable on backorder
Trifloxystrobin is a fungicide.{42423,42424} It inhibits the growth of R. solani isolates from sugar beet crops (EC50s = 0.14-823.54 μg/ml).{42423} Trifloxystrobin (100-1,000 ppm) inhibits mycelial growth of C. gloeosporioides when used in combination with tebuconazole (Item No. 24052).{42424} It is toxic to various aquatic species, including R. arenarum, P. santafecinus, E. bicolor, and L. latrans tadpoles (LC50s = 0.22, 0.14, 0.1, and 0.26 mg/L, respectively).{42425} It also reduces mobility of tadpoles and decreases predation of trifloxystrobin-exposed, but not non-exposed, tadpoles by eels.
Brand:CaymanSKU:25825 - 25 mgAvailable on backorder
Trifloxystrobin is a fungicide.{42423,42424} It inhibits the growth of R. solani isolates from sugar beet crops (EC50s = 0.14-823.54 μg/ml).{42423} Trifloxystrobin (100-1,000 ppm) inhibits mycelial growth of C. gloeosporioides when used in combination with tebuconazole (Item No. 24052).{42424} It is toxic to various aquatic species, including R. arenarum, P. santafecinus, E. bicolor, and L. latrans tadpoles (LC50s = 0.22, 0.14, 0.1, and 0.26 mg/L, respectively).{42425} It also reduces mobility of tadpoles and decreases predation of trifloxystrobin-exposed, but not non-exposed, tadpoles by eels.
Brand:CaymanSKU:25825 - 50 mgAvailable on backorder
Triflumuron is an insecticide and a chitin synthesis inhibitor.{59007} It reduces cuticle thickness in T. molitor pupae when administered at doses of 1 and 2 µg/insect.{59008} Topical application of triflumuron (1 µg/insect) to female M. domestica adults reduces egg hatching by greater than 95%.{59007} It induces mortality in A. aegypti, C. quinquefasciatus, and A. stephensi third instar larvae with EC50 values of 0.2, 0.3, and 0.1 ppb, respectively.{59009} Formulations containing triflumuron have been used as insecticides in agriculture.
Brand:CaymanSKU:30858 - 100 mgAvailable on backorder
Triflumuron is an insecticide and a chitin synthesis inhibitor.{59007} It reduces cuticle thickness in T. molitor pupae when administered at doses of 1 and 2 µg/insect.{59008} Topical application of triflumuron (1 µg/insect) to female M. domestica adults reduces egg hatching by greater than 95%.{59007} It induces mortality in A. aegypti, C. quinquefasciatus, and A. stephensi third instar larvae with EC50 values of 0.2, 0.3, and 0.1 ppb, respectively.{59009} Formulations containing triflumuron have been used as insecticides in agriculture.
Brand:CaymanSKU:30858 - 25 mgAvailable on backorder
Triflumuron is an insecticide and a chitin synthesis inhibitor.{59007} It reduces cuticle thickness in T. molitor pupae when administered at doses of 1 and 2 µg/insect.{59008} Topical application of triflumuron (1 µg/insect) to female M. domestica adults reduces egg hatching by greater than 95%.{59007} It induces mortality in A. aegypti, C. quinquefasciatus, and A. stephensi third instar larvae with EC50 values of 0.2, 0.3, and 0.1 ppb, respectively.{59009} Formulations containing triflumuron have been used as insecticides in agriculture.
Brand:CaymanSKU:30858 - 50 mgAvailable on backorder
Trifluoperazine (TFP) is a phenothiazine compound with anti-adrenergic and anti-dopaminergic actions typical of antipsychotic agents. It antagonizes adrenergic receptors, with selectivity for α1 over the α2 subtypes (Kis = 24, 653, 163, and 391 nM for α1A, α2A, α2B, and α2C, respectively).{24253} TFP binds with much higher affinity to the dopamine D2-like receptor (Kd = 0.96 nM) compared to the dopamine D4-like and the serotonin 5-HT2A receptors (Kds = 44 and 135 nM, respectively).{24252} Furthermore, TFP antagonizes calmodulin (CaM) and alters the calcium-binding properties of calsequestrin (CSQ).{23719,24254} TFP has been shown to activate type-2 ryanodine receptors independently of its CaM and CSQ activity.{24254}
Brand:CaymanSKU:- Trifluoperazine (TFP) is a phenothiazine compound with anti-adrenergic and anti-dopaminergic actions typical of antipsychotic agents. It antagonizes adrenergic receptors, with selectivity for α1 over the α2 subtypes (Kis = 24, 653, 163, and 391 nM for α1A, α2A, α2B, and α2C, respectively).{24253} TFP binds with much higher affinity to the dopamine D2-like receptor (Kd = 0.96 nM) compared to the dopamine D4-like and the serotonin 5-HT2A receptors (Kds = 44 and 135 nM, respectively).{24252} Furthermore, TFP antagonizes calmodulin (CaM) and alters the calcium-binding properties of calsequestrin (CSQ).{23719,24254} TFP has been shown to activate type-2 ryanodine receptors independently of its CaM and CSQ activity.{24254}
Brand:CaymanSKU:- Trifluoperazine (TFP) is a phenothiazine compound with anti-adrenergic and anti-dopaminergic actions typical of antipsychotic agents. It antagonizes adrenergic receptors, with selectivity for α1 over the α2 subtypes (Kis = 24, 653, 163, and 391 nM for α1A, α2A, α2B, and α2C, respectively).{24253} TFP binds with much higher affinity to the dopamine D2-like receptor (Kd = 0.96 nM) compared to the dopamine D4-like and the serotonin 5-HT2A receptors (Kds = 44 and 135 nM, respectively).{24252} Furthermore, TFP antagonizes calmodulin (CaM) and alters the calcium-binding properties of calsequestrin (CSQ).{23719,24254} TFP has been shown to activate type-2 ryanodine receptors independently of its CaM and CSQ activity.{24254}
Brand:CaymanSKU:- Trifluoperazine (TFP) is a phenothiazine compound with anti-adrenergic and anti-dopaminergic actions typical of antipsychotic agents. It antagonizes adrenergic receptors, with selectivity for α1 over the α2 subtypes (Kis = 24, 653, 163, and 391 nM for α1A, α2A, α2B, and α2C, respectively).{24253} TFP binds with much higher affinity to the dopamine D2-like receptor (Kd = 0.96 nM) compared to the dopamine D4-like and the serotonin 5-HT2A receptors (Kds = 44 and 135 nM, respectively).{24252} Furthermore, TFP antagonizes calmodulin (CaM) and alters the calcium-binding properties of calsequestrin (CSQ).{23719,24254} TFP has been shown to activate type-2 ryanodine receptors independently of its CaM and CSQ activity.{24254}
Brand:CaymanSKU:-
Trifluoperazine-d3 is intended for use as an internal standard for the quantification of trifluoperazine (Item No. 15068) by GC- or LC-MS. Trifluoperazine (TFP) is a phenothiazine compound with anti-adrenergic and anti-dopaminergic actions typical of antipsychotic agents.{24253} It antagonizes adrenergic receptors, with selectivity for α1 over the α2 subtypes (Kis = 24, 653, 163, and 391 nM for α1A, α2A, α2B, and α2C, respectively). TFP binds with much higher affinity to the dopamine D2-like receptor (Kd = 0.96 nM) compared to the dopamine D4-like and the serotonin 5-HT2A receptors (Kds = 44 and 135 nM, respectively).{24252} Furthermore, TFP antagonizes calmodulin (CaM) and alters the calcium-binding properties of calsequestrin (CSQ).{23719,24254} TFP has been shown to activate type-2 ryanodine receptors independently of its CaM and CSQ activity.{24254}
Brand:CaymanSKU:30718 - 1 mgAvailable on backorder
Trifluorothymidine is a derivative of thymidine that exhibits antiviral and anticancer activity by inhibiting thymidylate synthase, thereby blocking nucleic acid synthesis, and by incorporating into DNA, which leads to DNA damage and apoptosis.{33580}
Brand:CaymanSKU:21366 -Out of stock
Trifluorothymidine is a derivative of thymidine that exhibits antiviral and anticancer activity by inhibiting thymidylate synthase, thereby blocking nucleic acid synthesis, and by incorporating into DNA, which leads to DNA damage and apoptosis.{33580}
Brand:CaymanSKU:21366 -Out of stock