Cayman

Showing 42301–42450 of 45550 results

  • Tofogliflozin is a potent inhibitor of sodium glucose cotransporter 2 (SGLT2) with Ki values of 2.9, 14.9, and 6.4 nM for human, rat, and mouse SGLT2, respectively.{38569} It is selective for SGLT2 (IC50 = 2.9 nM) over other SGLTs (IC50s = >1,500 nM for SGLT1 and 3-6). Tofogliflozin (3-10 mg/kg) reduces plasma glucose concentrations and increases renal glucose clearance in Zucker diabetic fatty rats in a dose-dependent manner. It also reduces hyperglycemia in non-fasted db/db mice and decreases postprandial hyperglycemia in GK rats, a non-obese model of type 2 diabetes with glucose intolerance.  

     

    Brand:
    Cayman
    SKU:23509 - 25 mg

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  • Tofogliflozin is a potent inhibitor of sodium glucose cotransporter 2 (SGLT2) with Ki values of 2.9, 14.9, and 6.4 nM for human, rat, and mouse SGLT2, respectively.{38569} It is selective for SGLT2 (IC50 = 2.9 nM) over other SGLTs (IC50s = >1,500 nM for SGLT1 and 3-6). Tofogliflozin (3-10 mg/kg) reduces plasma glucose concentrations and increases renal glucose clearance in Zucker diabetic fatty rats in a dose-dependent manner. It also reduces hyperglycemia in non-fasted db/db mice and decreases postprandial hyperglycemia in GK rats, a non-obese model of type 2 diabetes with glucose intolerance.  

     

    Brand:
    Cayman
    SKU:23509 - 5 mg

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  • Tolazamide is a first generation sulfonylurea that inhibits sulfonylurea receptor 1 (SUR1) linked to the inwardly rectifying potassium channel (KIR6.2; IC50 = 4.2 µM in HEK293 cells transfected with the human receptor).{36318} It has no effect on glucose uptake in L6 rat skeletal muscle cells when used at a concentration of 0.6 mg/mL but enhances glucose uptake two-fold when used in combination with insulin.{40738} In vivo, tolazamide (128 mg/kg) reduces glomerulosclerosis and albumin excretion in a rat model of insulin-dependent diabetes induced by streptozotocin (Item No. 13104).{40739} Formulations containing tolazamide have been used in the treatment of type 2 diabetes.  

     

    Brand:
    Cayman
    SKU:23545 - 10 mg

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  • Tolazamide is a first generation sulfonylurea that inhibits sulfonylurea receptor 1 (SUR1) linked to the inwardly rectifying potassium channel (KIR6.2; IC50 = 4.2 µM in HEK293 cells transfected with the human receptor).{36318} It has no effect on glucose uptake in L6 rat skeletal muscle cells when used at a concentration of 0.6 mg/mL but enhances glucose uptake two-fold when used in combination with insulin.{40738} In vivo, tolazamide (128 mg/kg) reduces glomerulosclerosis and albumin excretion in a rat model of insulin-dependent diabetes induced by streptozotocin (Item No. 13104).{40739} Formulations containing tolazamide have been used in the treatment of type 2 diabetes.  

     

    Brand:
    Cayman
    SKU:23545 - 25 mg

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  • Tolazamide is a first generation sulfonylurea that inhibits sulfonylurea receptor 1 (SUR1) linked to the inwardly rectifying potassium channel (KIR6.2; IC50 = 4.2 µM in HEK293 cells transfected with the human receptor).{36318} It has no effect on glucose uptake in L6 rat skeletal muscle cells when used at a concentration of 0.6 mg/mL but enhances glucose uptake two-fold when used in combination with insulin.{40738} In vivo, tolazamide (128 mg/kg) reduces glomerulosclerosis and albumin excretion in a rat model of insulin-dependent diabetes induced by streptozotocin (Item No. 13104).{40739} Formulations containing tolazamide have been used in the treatment of type 2 diabetes.  

     

    Brand:
    Cayman
    SKU:23545 - 5 mg

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  • Tolazamide is a first generation sulfonylurea that inhibits sulfonylurea receptor 1 (SUR1) linked to the inwardly rectifying potassium channel (KIR6.2; IC50 = 4.2 µM in HEK293 cells transfected with the human receptor).{36318} It has no effect on glucose uptake in L6 rat skeletal muscle cells when used at a concentration of 0.6 mg/mL but enhances glucose uptake two-fold when used in combination with insulin.{40738} In vivo, tolazamide (128 mg/kg) reduces glomerulosclerosis and albumin excretion in a rat model of insulin-dependent diabetes induced by streptozotocin (Item No. 13104).{40739} Formulations containing tolazamide have been used in the treatment of type 2 diabetes.  

     

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    Cayman
    SKU:23545 - 50 mg

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  • Tolazoline is a competitive α1- and α2-adrenergic receptor antagonist (pKis ~6.5) well-known for its peripheral vasodilator effects in animal models.{30609,30610} It also is reported to produce histamine-like effects that are sensitive to histamine H2-receptor antagonism in whole animals and a variety of isolated tissues.{30608} Certain α2-adrenergic receptor antagonists, including tolazoline, are most commonly used in veterinary medicine as reversal agents for the sedative effects of α2-adrenergic receptor agonists such as xylazine (Item No. 14113).{30610}  

     

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  • Tolazoline is a competitive α1- and α2-adrenergic receptor antagonist (pKis ~6.5) well-known for its peripheral vasodilator effects in animal models.{30609,30610} It also is reported to produce histamine-like effects that are sensitive to histamine H2-receptor antagonism in whole animals and a variety of isolated tissues.{30608} Certain α2-adrenergic receptor antagonists, including tolazoline, are most commonly used in veterinary medicine as reversal agents for the sedative effects of α2-adrenergic receptor agonists such as xylazine (Item No. 14113).{30610}  

     

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    SKU:-

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  • Tolazoline is a competitive α1- and α2-adrenergic receptor antagonist (pKis ~6.5) well-known for its peripheral vasodilator effects in animal models.{30609,30610} It also is reported to produce histamine-like effects that are sensitive to histamine H2-receptor antagonism in whole animals and a variety of isolated tissues.{30608} Certain α2-adrenergic receptor antagonists, including tolazoline, are most commonly used in veterinary medicine as reversal agents for the sedative effects of α2-adrenergic receptor agonists such as xylazine (Item No. 14113).{30610}  

     

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  • Tolbutamide is an inhibitor of sulfonylurea receptor 1 (SUR1) linked to ATP-sensitive potassium channel Kir6.2 (IC50 = 4.9 µM).{34125} It is selective for SUR1/Kir6.2 over SUR2A/Kir6.2 and SUR2B/Kir6.2 channels (IC50s = 85 and 88 µM, respectively). Tolbutamide increases glucose-induced insulin secretion and calcium influx in isolated mouse pancreatic islets.{54189} In vivo, tolbutamide (80 mg/kg) reduces blood glucose levels in a mouse model of diabetes induced by streptozotocin (STZ; Item No. 13104).{54190} Formulations containing tolbutamide have been used in the treatment of type 2 diabetes.  

     

    Brand:
    Cayman
    SKU:19888 -

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  • Tolbutamide is an inhibitor of sulfonylurea receptor 1 (SUR1) linked to ATP-sensitive potassium channel Kir6.2 (IC50 = 4.9 µM).{34125} It is selective for SUR1/Kir6.2 over SUR2A/Kir6.2 and SUR2B/Kir6.2 channels (IC50s = 85 and 88 µM, respectively). Tolbutamide increases glucose-induced insulin secretion and calcium influx in isolated mouse pancreatic islets.{54189} In vivo, tolbutamide (80 mg/kg) reduces blood glucose levels in a mouse model of diabetes induced by streptozotocin (STZ; Item No. 13104).{54190} Formulations containing tolbutamide have been used in the treatment of type 2 diabetes.  

     

    Brand:
    Cayman
    SKU:19888 -

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  • Tolbutamide is an inhibitor of sulfonylurea receptor 1 (SUR1) linked to ATP-sensitive potassium channel Kir6.2 (IC50 = 4.9 µM).{34125} It is selective for SUR1/Kir6.2 over SUR2A/Kir6.2 and SUR2B/Kir6.2 channels (IC50s = 85 and 88 µM, respectively). Tolbutamide increases glucose-induced insulin secretion and calcium influx in isolated mouse pancreatic islets.{54189} In vivo, tolbutamide (80 mg/kg) reduces blood glucose levels in a mouse model of diabetes induced by streptozotocin (STZ; Item No. 13104).{54190} Formulations containing tolbutamide have been used in the treatment of type 2 diabetes.  

     

    Brand:
    Cayman
    SKU:19888 -

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  • Tolbutamide is an inhibitor of sulfonylurea receptor 1 (SUR1) linked to ATP-sensitive potassium channel Kir6.2 (IC50 = 4.9 µM).{34125} It is selective for SUR1/Kir6.2 over SUR2A/Kir6.2 and SUR2B/Kir6.2 channels (IC50s = 85 and 88 µM, respectively). Tolbutamide increases glucose-induced insulin secretion and calcium influx in isolated mouse pancreatic islets.{54189} In vivo, tolbutamide (80 mg/kg) reduces blood glucose levels in a mouse model of diabetes induced by streptozotocin (STZ; Item No. 13104).{54190} Formulations containing tolbutamide have been used in the treatment of type 2 diabetes.  

     

    Brand:
    Cayman
    SKU:19888 -

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  • Tolbutamide-d9 is intended for use as an internal standard for the quantification of tolbutamide (Item No. 19888) by GC- or LC-MS. Tolbutamide is an inhibitor of sulfonylurea receptor 1 (SUR1) linked to ATP-sensitive potassium channel Kir6.2 (IC50 = 4.9 µM).{34125} It is selective for SUR1/Kir6.2 over SUR2A/Kir6.2 and SUR2B/Kir6.2 channels (IC50s = 85 and 88 µM, respectively). Tolbutamide increases glucose-induced insulin secretion and calcium influx in isolated mouse pancreatic islets.{54189} In vivo, tolbutamide (80 mg/kg) reduces blood glucose levels in a mouse model of diabetes induced by streptozotocin (STZ; Item No. 13104).{54190} Formulations containing tolbutamide have been used in the treatment of type 2 diabetes.  

     

    Brand:
    Cayman
    SKU:30738 - 1 mg

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  • Tolbutamide-d9 is intended for use as an internal standard for the quantification of tolbutamide (Item No. 19888) by GC- or LC-MS. Tolbutamide is an inhibitor of sulfonylurea receptor 1 (SUR1) linked to ATP-sensitive potassium channel Kir6.2 (IC50 = 4.9 µM).{34125} It is selective for SUR1/Kir6.2 over SUR2A/Kir6.2 and SUR2B/Kir6.2 channels (IC50s = 85 and 88 µM, respectively). Tolbutamide increases glucose-induced insulin secretion and calcium influx in isolated mouse pancreatic islets.{54189} In vivo, tolbutamide (80 mg/kg) reduces blood glucose levels in a mouse model of diabetes induced by streptozotocin (STZ; Item No. 13104).{54190} Formulations containing tolbutamide have been used in the treatment of type 2 diabetes.  

     

    Brand:
    Cayman
    SKU:30738 - 10 mg

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  • Tolbutamide-d9 is intended for use as an internal standard for the quantification of tolbutamide (Item No. 19888) by GC- or LC-MS. Tolbutamide is an inhibitor of sulfonylurea receptor 1 (SUR1) linked to ATP-sensitive potassium channel Kir6.2 (IC50 = 4.9 µM).{34125} It is selective for SUR1/Kir6.2 over SUR2A/Kir6.2 and SUR2B/Kir6.2 channels (IC50s = 85 and 88 µM, respectively). Tolbutamide increases glucose-induced insulin secretion and calcium influx in isolated mouse pancreatic islets.{54189} In vivo, tolbutamide (80 mg/kg) reduces blood glucose levels in a mouse model of diabetes induced by streptozotocin (STZ; Item No. 13104).{54190} Formulations containing tolbutamide have been used in the treatment of type 2 diabetes.  

     

    Brand:
    Cayman
    SKU:30738 - 5 mg

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  • Tolcapone is a reversible inhibitor of catechol-O-methyltransferase (COMT; Ki = 0.27 nM for human recombinant COMT), an enzyme that degrades catecholamines, including dopamine and L-DOPA (Item No. 13248).{42962,22704} Tolcapone crosses the blood brain barrier and can inhibit both peripheral and central COMT activity.{32113,22703} By inhibiting COMT, tolcapone increases L-DOPA efficacy and reduces L-DOPA-induced motor complications in animal models of Parkinson’s disease.{32113}  

     

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    Cayman
    SKU:20768 -

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  • Tolcapone is a reversible inhibitor of catechol-O-methyltransferase (COMT; Ki = 0.27 nM for human recombinant COMT), an enzyme that degrades catecholamines, including dopamine and L-DOPA (Item No. 13248).{42962,22704} Tolcapone crosses the blood brain barrier and can inhibit both peripheral and central COMT activity.{32113,22703} By inhibiting COMT, tolcapone increases L-DOPA efficacy and reduces L-DOPA-induced motor complications in animal models of Parkinson’s disease.{32113}  

     

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    Cayman
    SKU:20768 -

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  • Tolcapone is a reversible inhibitor of catechol-O-methyltransferase (COMT; Ki = 0.27 nM for human recombinant COMT), an enzyme that degrades catecholamines, including dopamine and L-DOPA (Item No. 13248).{42962,22704} Tolcapone crosses the blood brain barrier and can inhibit both peripheral and central COMT activity.{32113,22703} By inhibiting COMT, tolcapone increases L-DOPA efficacy and reduces L-DOPA-induced motor complications in animal models of Parkinson’s disease.{32113}  

     

    Brand:
    Cayman
    SKU:20768 -

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  • Tolcapone is a reversible inhibitor of catechol-O-methyltransferase (COMT; Ki = 0.27 nM for human recombinant COMT), an enzyme that degrades catecholamines, including dopamine and L-DOPA (Item No. 13248).{42962,22704} Tolcapone crosses the blood brain barrier and can inhibit both peripheral and central COMT activity.{32113,22703} By inhibiting COMT, tolcapone increases L-DOPA efficacy and reduces L-DOPA-induced motor complications in animal models of Parkinson’s disease.{32113}  

     

    Brand:
    Cayman
    SKU:20768 -

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  • Tolcapone-d4 is intended for use as an internal standard for the quantification of tolcapone (Item No. 20768) by GC- or LC-MS. Tolcapone is a reversible inhibitor of catechol-O-methyltransferase (COMT; Ki = 0.27 nM for human recombinant COMT), an enzyme that degrades catecholamines, including dopamine (Item No. 21992) and L-DOPA (Item No. 13248).{42962,22704} Tolcapone crosses the blood brain barrier and can inhibit both peripheral and central COMT activity.{32113,22703} By inhibiting COMT, tolcapone increases L-DOPA efficacy and reduces L-DOPA-induced motor complications in animal models of Parkinson’s disease.{32113}  

     

    Brand:
    Cayman
    SKU:28697 - 1 mg

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  • Tolfenamic acid is a non-steroidal anti-inflammatory drug (NSAID) with anticancer activity.{52184,1819,52185,52186,52187} It is selective for COX-2 over COX-1 in canine DH82 monocyte/macrophage cells (IC50s = 3.53 and >51.2 μg/ml, respectively).{52184} Tolfenamic acid inhibits calcium influx in human polymorphonuclear leukocytes (PMNLs) induced by N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP; Item No. 21495) or the calcium ionophore A23187 (Item Nos. 11016 | 22030) in a concentration-dependent manner.{1819} It decreases protein levels of the transcription factors Sp1, Sp3, and Sp4 in PANC-1 and L3.6pl cells when used at a concentration of 50 μM and inhibits proliferation of PANC-1, L3.6pl, and PANC-28 cells in a concentration-dependent manner.{52186} Tolfenamic acid (50 and 100 μM) decreases the viability of and induces apoptosis in MDA-MB-231 cells.{52187} It reduces tumor growth in an MDA-MB-231 mouse xenograft model when administered at doses of 25 and 50 mg/kg. Tolfenamic acid (150 μmol/kg) reduces carrageenan-induced paw edema in mice by 24%.{52185}  

     

    Brand:
    Cayman
    SKU:70480 - 10 g

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  • Tolfenamic acid is a non-steroidal anti-inflammatory drug (NSAID) with anticancer activity.{52184,1819,52185,52186,52187} It is selective for COX-2 over COX-1 in canine DH82 monocyte/macrophage cells (IC50s = 3.53 and >51.2 μg/ml, respectively).{52184} Tolfenamic acid inhibits calcium influx in human polymorphonuclear leukocytes (PMNLs) induced by N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP; Item No. 21495) or the calcium ionophore A23187 (Item Nos. 11016 | 22030) in a concentration-dependent manner.{1819} It decreases protein levels of the transcription factors Sp1, Sp3, and Sp4 in PANC-1 and L3.6pl cells when used at a concentration of 50 μM and inhibits proliferation of PANC-1, L3.6pl, and PANC-28 cells in a concentration-dependent manner.{52186} Tolfenamic acid (50 and 100 μM) decreases the viability of and induces apoptosis in MDA-MB-231 cells.{52187} It reduces tumor growth in an MDA-MB-231 mouse xenograft model when administered at doses of 25 and 50 mg/kg. Tolfenamic acid (150 μmol/kg) reduces carrageenan-induced paw edema in mice by 24%.{52185}  

     

    Brand:
    Cayman
    SKU:70480 - 25 g

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  • Tolfenamic acid is a non-steroidal anti-inflammatory drug (NSAID) with anticancer activity.{52184,1819,52185,52186,52187} It is selective for COX-2 over COX-1 in canine DH82 monocyte/macrophage cells (IC50s = 3.53 and >51.2 μg/ml, respectively).{52184} Tolfenamic acid inhibits calcium influx in human polymorphonuclear leukocytes (PMNLs) induced by N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP; Item No. 21495) or the calcium ionophore A23187 (Item Nos. 11016 | 22030) in a concentration-dependent manner.{1819} It decreases protein levels of the transcription factors Sp1, Sp3, and Sp4 in PANC-1 and L3.6pl cells when used at a concentration of 50 μM and inhibits proliferation of PANC-1, L3.6pl, and PANC-28 cells in a concentration-dependent manner.{52186} Tolfenamic acid (50 and 100 μM) decreases the viability of and induces apoptosis in MDA-MB-231 cells.{52187} It reduces tumor growth in an MDA-MB-231 mouse xenograft model when administered at doses of 25 and 50 mg/kg. Tolfenamic acid (150 μmol/kg) reduces carrageenan-induced paw edema in mice by 24%.{52185}  

     

    Brand:
    Cayman
    SKU:70480 - 5 g

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  • Tolfenamic acid-d4 is intended for use as an internal standard for the quantification of tolfenamic acid (Item No. 70480) by GC- or LC-MS. Tolfenamic acid is a non-steroidal anti-inflammatory drug (NSAID) with anticancer activity.{52184,1819,52185,52186,52187} It is selective for COX-2 over COX-1 in canine DH82 monocyte/macrophage cells (IC50s = 3.53 and >51.2 μg/ml, respectively).{52184} Tolfenamic acid inhibits calcium influx in human polymorphonuclear leukocytes (PMNLs) induced by N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP; Item No. 21495) or the calcium ionophore A23187 (Item Nos. 11016 | 22030) in a concentration-dependent manner.{1819} It decreases protein levels of the transcription factors Sp1, Sp3, and Sp4 in PANC-1 and L3.6pl cells when used at a concentration of 50 μM and inhibits proliferation of PANC-1, L3.6pl, and PANC-28 cells in a concentration-dependent manner.{52186} Tolfenamic acid (50 and 100 μM) decreases the viability of and induces apoptosis in MDA-MB-231 cells.{52187} It reduces tumor growth in an MDA-MB-231 mouse xenograft model when administered at doses of 25 and 50 mg/kg. Tolfenamic acid (150 μmol/kg) reduces carrageenan-induced paw edema in mice by 24%.{52185}  

     

    Brand:
    Cayman
    SKU:28700 - 1 mg

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  • Tolfenamic acid-d4 is intended for use as an internal standard for the quantification of tolfenamic acid (Item No. 70480) by GC- or LC-MS. Tolfenamic acid is a non-steroidal anti-inflammatory drug (NSAID) with anticancer activity.{52184,1819,52185,52186,52187} It is selective for COX-2 over COX-1 in canine DH82 monocyte/macrophage cells (IC50s = 3.53 and >51.2 μg/ml, respectively).{52184} Tolfenamic acid inhibits calcium influx in human polymorphonuclear leukocytes (PMNLs) induced by N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP; Item No. 21495) or the calcium ionophore A23187 (Item Nos. 11016 | 22030) in a concentration-dependent manner.{1819} It decreases protein levels of the transcription factors Sp1, Sp3, and Sp4 in PANC-1 and L3.6pl cells when used at a concentration of 50 μM and inhibits proliferation of PANC-1, L3.6pl, and PANC-28 cells in a concentration-dependent manner.{52186} Tolfenamic acid (50 and 100 μM) decreases the viability of and induces apoptosis in MDA-MB-231 cells.{52187} It reduces tumor growth in an MDA-MB-231 mouse xenograft model when administered at doses of 25 and 50 mg/kg. Tolfenamic acid (150 μmol/kg) reduces carrageenan-induced paw edema in mice by 24%.{52185}  

     

    Brand:
    Cayman
    SKU:28700 - 5 mg

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  • The toll-like receptors (TLRs) in mammals comprise a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and an interleukin-1 (IL-1) receptor motif in the cytoplasmic domain. Like their counterparts in Drosophila, TLRs signal through adaptor molecules.{17463} The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition.{17464} Most mammalian species have between ten and fifteen types of TLRs. Ten functional TLRs (TLR1-10) have been identified in human. Humans also encode a TLR11 gene but it contains several stop codons and protein is not expressed. However, mouse and rat TLR11 are functional, and it is thought that human TLR11 function was lost during evolution. TLR2 is differentially expressed in human cells. Historically speaking, TLR expression has been most extensively studied in the immune system. Overall, TLRs are highly expressed in immune competent cells, including macrophages, dendritic cells, neutrophils, mucosal epithelial cells and dermal endothelial cells. However, TLRs have also been identified in many other cell types and anatomical tissue locations where they are expressed either constitutively or induced during infection. In mice, TLR1 interacts with TLR2 and coexpression of TLR1 and TLR2 enhances the NF-kB activation in response to a synthetic lipopeptide. Together, they recognize the lipid configuration of the native mycobacterial lipoprotein as well as several triacylated lipopeptides.  

     

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    SKU:13582 - 1 ea

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  • Antigen: peptide from human TLR1 within the region of amino acids 400-450 • Host: rabbit • Cross Reactivity: (+) human, mouse, and rat TLR1 • Application(s): FC (intracellular and cell surface) and WB • TLR1 interacts with TLR2 and coexpression of TLR1 and TLR2 enhances the NF-kB activation in response to a synthetic lipopeptide. Together, they recognize the lipid configuration of the native mycobacterial lipoprotein as well as several triacylated lipopeptides.  

     

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    SKU:13582- 1 ea

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  • Antigen: peptide from human TLR1 within the region of amino acids 400-450 • Host: rabbit • Cross Reactivity: (+) human, mouse, and rat TLR1 • Application(s): FC (intracellular and cell surface) and WB • TLR1 interacts with TLR2 and coexpression of TLR1 and TLR2 enhances the NF-kB activation in response to a synthetic lipopeptide. Together, they recognize the lipid configuration of the native mycobacterial lipoprotein as well as several triacylated lipopeptides.  

     

    Brand:
    Cayman
    SKU:13582- 1 ea
  • The toll-like receptors (TLRs) in mammals comprise a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and an interleukin-1 (IL-1) receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules.{17463} The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition.{17464} Most mammalian species have between ten and fifteen types of TLRs. Ten functional TLRs (TLR1-10) have been identified in human. Humans also encode a TLR11 gene but it contains several stop codons and protein is not expressed. However, mouse and rat TLR11 are functional, and it is thought that human TLR11 function was lost during evolution. Historically speaking, TLR expression has been most extensively studied in the immune system. Overall, TLRs are highly expressed in immune competent cells, including macrophages, dendritic cells, neutrophils, mucosal epithelial cells and dermal endothelial cells. However, TLRs have also been identified in many other cell types and anatomical tissue locations where they are expressed either constitutively or induced during infection. TLR12 displays a distinct pattern of expression in macrophages, liver, kidney, and bladder epithelial cells. TLR12 does not respond to known TLR ligands.  

     

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    SKU:13586 - 1 ea

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  • Antigen: mouse TLR12 amino acids 911-926 • Host: rabbit • Cross Reactivity: (+) mouse and rat TLR12 • Application(s): FC (intracellular) and WB • TLR12 displays a distinct pattern of expression in macrophages, liver, kidney, and bladder epithelial cells. TLR12 does not respond to known TLR ligands.  

     

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    Cayman
    SKU:13586- 1 ea

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  • Antigen: mouse TLR12 amino acids 911-926 • Host: rabbit • Cross Reactivity: (+) mouse and rat TLR12 • Application(s): FC (intracellular) and WB • TLR12 displays a distinct pattern of expression in macrophages, liver, kidney, and bladder epithelial cells. TLR12 does not respond to known TLR ligands.  

     

    Brand:
    Cayman
    SKU:13586- 1 ea
  • The toll-like receptors (TLRs) in mammals comprise a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and an interleukin-1 (IL-1) receptor motif in the cytoplasmic domain. Like their counterparts in Drosophila, TLRs signal through adaptor molecules.{17463} The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition.{17464} Most mammalian species have between ten and fifteen types of TLRs. Ten functional TLRs (TLR1-10) have been identified in human. Humans also encode a TLR11 gene but it contains several stop codons and protein is not expressed. However, murine and rat TLR11 are functional, and it is thought that human TLR11 function was lost during evolution. TLR2 is differentially expressed in human cells. Historically speaking, TLR expression has been most extensively studied in the immune system. Overall, TLRs are highly expressed in immune competent cells, including macrophages, dendritic cells, neutrophils, mucosal epithelial cells, and dermal endothelial cells. However, TLRs have also been identified in many other cell types and anatomical tissue locations where they are expressed either constitutively or induced during infection.  

     

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    Cayman
    SKU:13587 - 1 ea

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  • Antigen: CHO cells transfected with human TLR2 cDNA • Host: mouse, clone TL2.1 • Cross Reactivity: (+) human and canine TLR2 • Application(s): FC (intracellular and cell surface), ICC, IHC, IP, and WB • TLR2 interacts with TLR1 and coexpression of TLR1 and TLR2 enhances the NF-kB activation in response to a synthetic lipopeptide. Together, they recognize the lipid configuration of the native mycobacterial lipoprotein as well as several triacylated lipopeptides.  

     

    Brand:
    Cayman
    SKU:13587- 1 ea

    Available on backorder

  • Antigen: CHO cells transfected with human TLR2 cDNA • Host: mouse, clone TL2.1 • Cross Reactivity: (+) human and canine TLR2 • Application(s): FC (intracellular and cell surface), ICC, IHC, IP, and WB • TLR2 interacts with TLR1 and coexpression of TLR1 and TLR2 enhances the NF-kB activation in response to a synthetic lipopeptide. Together, they recognize the lipid configuration of the native mycobacterial lipoprotein as well as several triacylated lipopeptides.  

     

    Brand:
    Cayman
    SKU:13587- 1 ea
  • The toll-like receptors (TLRs) in mammals comprise a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and an interleukin-1 (IL-1) receptor motif in the cytoplasmic domain. Like their counterparts in Drosophila, TLRs signal through adaptor molecules.{17463} The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition.{17464} Most mammalian species have between ten and fifteen types of TLRs. Ten functional TLRs (TLR1-10) have been identified in human. Humans also encode a TLR11 gene but it contains several stop codons and protein is not expressed. However, mouse and rat TLR11 are functional, and it is thought that human TLR11 function was lost during evolution. Historically speaking, TLR expression has been most extensively studied in the immune system. Overall, TLRs are highly expressed in immune competent cells, including macrophages, dendritic cells, neutrophils, mucosal epithelial cells and dermal endothelial cells. However, TLRs have also been identified in many other cell types and anatomical tissue locations where they are expressed either constitutively or induced during infection. TLR3 cDNA codes for a protein with approximate molecular weight of 120 kDa.{17488} TLR3 has a restricted expression pattern being expressed in dendritic cells (DC).{17488,17489,17490} The expression of TLR3 in a single cell type may indicate a specific role for this molecule in a restricted setting.  

     

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    SKU:13588 - 1 ea

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  • Antigen: human TLR3 amino acids 55-70 • Host: mouse, clone 40C1285.6 • Cross Reactivity: (+) human and canine TLR3 • Application(s): FC (intracellular and cell surface), ICC, IHC, IP, and WB • TLR3 has a restricted expression pattern being expressed in dendritic cells. The expression of TLR3 in a single cell type may indicate a specific role for this molecule in a restricted setting.  

     

    Brand:
    Cayman
    SKU:13588- 1 ea

    Available on backorder

  • Antigen: human TLR3 amino acids 55-70 • Host: mouse, clone 40C1285.6 • Cross Reactivity: (+) human and canine TLR3 • Application(s): FC (intracellular and cell surface), ICC, IHC, IP, and WB • TLR3 has a restricted expression pattern being expressed in dendritic cells. The expression of TLR3 in a single cell type may indicate a specific role for this molecule in a restricted setting.  

     

    Brand:
    Cayman
    SKU:13588- 1 ea
  • The toll-like receptors (TLRs) in mammals comprise a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and an interleukin-1 (IL-1) receptor motif in the cytoplasmic domain. Like their counterparts in Drosophila, TLRs signal through adaptor molecules.{17463} The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition.{17464} Most mammalian species have between ten and fifteen types of TLRs. Ten functional TLRs (TLR1-10) have been identified in human. Humans also encode a TLR11 gene but it contains several stop codons and protein is not expressed. However, mouse and rat TLR11 are functional, and it is thought that human TLR11 function was lost during evolution. Historically speaking, TLR expression has been most extensively studied in the immune system. Overall, TLRs are highly expressed in immune competent cells, including macrophages, dendritic cells, neutrophils, mucosal epithelial cells and dermal endothelial cells. However, TLRs have also been identified in many other cell types and anatomical tissue locations where they are expressed either constitutively or induced during infection. Among this family of receptors TLR2 and TLR4 have been most studied. These studies have suggested that TLR2 and TLR4 may serve as potential main mediators of LPS signaling.{17497,17500} The TLR4 cDNA codes for a protein consisting of 799 amino acids with approximate molecular weight of 88 kDa.{17501}  

     

    Brand:
    Cayman
    SKU:13589 - 1 ea

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  • Antigen: Ba/F3 cell line expressing human TLR4 cell surface antigen • Isotype: IgG2aK • Host: mouse, clone HTA125 • Cross Reactivity: (+) human and canine TLR4 • Application(s): FC (cell surface and intracellular), ICC, IP, and neutralization • TLR4 is mediator of innate immunity that is essential for microbial recognition and serves as one of the main mediators of LPS signaling.  

     

    Brand:
    Cayman
    SKU:13589- 1 ea

    Available on backorder

  • Antigen: Ba/F3 cell line expressing human TLR4 cell surface antigen • Isotype: IgG2aK • Host: mouse, clone HTA125 • Cross Reactivity: (+) human and canine TLR4 • Application(s): FC (cell surface and intracellular), ICC, IP, and neutralization • TLR4 is mediator of innate immunity that is essential for microbial recognition and serves as one of the main mediators of LPS signaling.  

     

    Brand:
    Cayman
    SKU:13589- 1 ea
  • A potential treatment for hepatitis C virus (HCV) is to induce immune cell-derived interferon (IFN) production using synthetic agonists of toll-like receptor 7 (TLR7). TLR7 ligand II is an orally bioavailable 8-hydroxyadenine analog that induces IFN production by binding to TLR7 on immune cells.{28465,28466} It induces IFNα in human peripheral blood mononuclear cells with an EC50 value of 0.14 µM.{28466} At 10 µM, TLR7 ligand II was shown to reduce HCV levels by 60% in 24 hours in the human hepatocyte cell line Huh7, which carries a HCV replicon.{28467} It induces IFN in mice with a minimal effective dose of approximately 0.03 mg/kg, making it approximately 100-fold more potent than imiquimod (Item No. 14956).{28465}  

     

    Brand:
    Cayman
    SKU:-

    Out of stock

  • A potential treatment for hepatitis C virus (HCV) is to induce immune cell-derived interferon (IFN) production using synthetic agonists of toll-like receptor 7 (TLR7). TLR7 ligand II is an orally bioavailable 8-hydroxyadenine analog that induces IFN production by binding to TLR7 on immune cells.{28465,28466} It induces IFNα in human peripheral blood mononuclear cells with an EC50 value of 0.14 µM.{28466} At 10 µM, TLR7 ligand II was shown to reduce HCV levels by 60% in 24 hours in the human hepatocyte cell line Huh7, which carries a HCV replicon.{28467} It induces IFN in mice with a minimal effective dose of approximately 0.03 mg/kg, making it approximately 100-fold more potent than imiquimod (Item No. 14956).{28465}  

     

    Brand:
    Cayman
    SKU:-

    Out of stock

  • The toll-like receptors (TLRs) in mammals comprise a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and an interleukin-1 (IL-1) receptor motif in the cytoplasmic domain. Like their counterparts in Drosophila, TLRs signal through adaptor molecules.{17463} The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition.{17464} Most mammalian species have between ten and fifteen types of TLRs. Ten functional TLRs (TLR1-10) have been identified in human. Humans also encode a TLR11 gene but it contains several stop codons and protein is not expressed. However, mouse and rat TLR11 are functional, and it is thought that human TLR11 function was lost during evolution. Historically speaking, TLR expression has been most extensively studied in the immune system. Overall, TLRs are highly expressed in immune competent cells, including macrophages, dendritic cells, neutrophils, mucosal epithelial cells and dermal endothelial cells. However, TLRs have also been identified in many other cell types and anatomical tissue locations where they are expressed either constitutively or induced during infection. Stimulation of the NF-κB signaling pathway by TLR7 suggests that it plays a role in immune response.  

     

    Brand:
    Cayman
    SKU:13591 - 1 ea

    Available on backorder

  • Antigen: human TLR7 amino acids 706-728 • Host: rabbit • Cross Reactivity: (+) human, mouse, and rat TLR7 • Application(s): FC (intracellular and cell surface), ICC, IHC (frozen and paraffin-embedded sections), IP, and WB • Stimulation of the NF-κB signaling pathway by TLR7 suggests that it plays a role in immune response.  

     

    Brand:
    Cayman
    SKU:13591- 1 ea

    Available on backorder

  • Antigen: human TLR7 amino acids 706-728 • Host: rabbit • Cross Reactivity: (+) human, mouse, and rat TLR7 • Application(s): FC (intracellular and cell surface), ICC, IHC (frozen and paraffin-embedded sections), IP, and WB • Stimulation of the NF-κB signaling pathway by TLR7 suggests that it plays a role in immune response.  

     

    Brand:
    Cayman
    SKU:13591- 1 ea
  • The toll-like receptors (TLRs) in mammals comprise a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and an interleukin-1 (IL-1) receptor motif in the cytoplasmic domain. Like their counterparts in Drosophila, TLRs signal through adaptor molecules.{17463} The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition.{17464} Most mammalian species have between ten and fifteen types of TLRs. Ten functional TLRs (TLR1-10) have been identified in human. Humans also encode a TLR11 gene but it contains several stop codons and protein is not expressed. However, mouse and rat TLR11 are functional, and it is thought that human TLR11 function was lost during evolution. Historically speaking, TLR expression has been most extensively studied in the immune system. Overall, TLRs are highly expressed in immune competent cells, including macrophages, dendritic cells, neutrophils, mucosal epithelial cells and dermal endothelial cells. However, TLRs have also been identified in many other cell types and anatomical tissue locations where they are expressed either constitutively or induced during infection. The TLR8 gene contains three exons, two of which have coding function.{17573} TLR8 cDNA codes for a protein of approximate molecular weight of 120 kDa.{17573,17574}  

     

    Brand:
    Cayman
    SKU:13592 - 1 ea

    Available on backorder

  • Antigen: peptide from human TLR8 within the region of amino acids 750-850 • Host: mouse, clone 44C143 • Cross Reactivity: (+) human and mouse TLR8 • Application(s): FC (intracellular and cell surface), IHC (paraffin-embedded sections), and WB • TLRs mediate innate immunity that is essential for microbial recognition. The TLR8 gene contains three exons, two of which have coding function.  

     

    Brand:
    Cayman
    SKU:13592- 1 ea

    Available on backorder

  • Antigen: peptide from human TLR8 within the region of amino acids 750-850 • Host: mouse, clone 44C143 • Cross Reactivity: (+) human and mouse TLR8 • Application(s): FC (intracellular and cell surface), IHC (paraffin-embedded sections), and WB • TLRs mediate innate immunity that is essential for microbial recognition. The TLR8 gene contains three exons, two of which have coding function.  

     

    Brand:
    Cayman
    SKU:13592- 1 ea
  • The toll-like receptors (TLRs) in mammals comprise a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and an interleukin-1 (IL-1) receptor motif in the cytoplasmic domain. Like their counterparts in Drosophila, TLRs signal through adaptor molecules.{17463} The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition.{17464} Most mammalian species have between ten and fifteen types of TLRs. Ten functional TLRs (TLR1-10) have been identified in human. Humans also encode a TLR11 gene but it contains several stop codons and protein is not expressed. However, mouse and rat TLR11 are functional, and it is thought that human TLR11 function was lost during evolution. Historically speaking, TLR expression has been most extensively studied in the immune system. Overall, TLRs are highly expressed in immune competent cells, including macrophages, dendritic cells, neutrophils, mucosal epithelial cells and dermal endothelial cells. However, TLRs have also been identified in many other cell types and anatomical tissue locations where they are expressed either constitutively or induced during infection. Gene knockout experiments suggest that TLR9 acts as a receptor for unmethylated CpG dinucleotides in bacterial DNA.{17576} Human and mouse TLR9 share an overall amino acid identity of 75.5%. TLR9 is highly expressed in spleen.  

     

    Brand:
    Cayman
    SKU:13593 - 1 ea

    Available on backorder

  • Antigen: human TLR9 amino acids 268-284 • Host: mouse, clone 26C593.2 • Cross Reactivity: (+) canine, equine, human, mouse, rat, and Rhesus monkey TLR9 • Application(s): FC (intracellular and cell surface), ICC, IHC (frozen and paraffin), and WB • Gene knockout experiments suggest that TLR9 acts as a receptor for unmethylated CpG dinucleotides in bacterial DNA.TLR9 is highly expressed in spleen.  

     

    Brand:
    Cayman
    SKU:13593- 1 ea

    Available on backorder

  • Antigen: human TLR9 amino acids 268-284 • Host: mouse, clone 26C593.2 • Cross Reactivity: (+) canine, equine, human, mouse, rat, and Rhesus monkey TLR9 • Application(s): FC (intracellular and cell surface), ICC, IHC (frozen and paraffin), and WB • Gene knockout experiments suggest that TLR9 acts as a receptor for unmethylated CpG dinucleotides in bacterial DNA.TLR9 is highly expressed in spleen.  

     

    Brand:
    Cayman
    SKU:13593- 1 ea
  • Tolmetin is a non-steroidal anti-inflammatory drug that non-selectively inhibits human COX-1 and -2 with IC50 values of 0.35 and 0.82 µM, respectively.{8427} It also inhibits aldo-keto reductases (e.g., IC50 = 2.39 µM for human aldose reductase), a family of enzymes that catalyze the NADPH-dependent reduction of carbonyl groups in a number of important steroid, metabolic, and prostanoid molecules.{27311,29322}  

     

    Brand:
    Cayman
    SKU:-

    Available on backorder

  • Tolmetin is a non-steroidal anti-inflammatory drug that non-selectively inhibits human COX-1 and -2 with IC50 values of 0.35 and 0.82 µM, respectively.{8427} It also inhibits aldo-keto reductases (e.g., IC50 = 2.39 µM for human aldose reductase), a family of enzymes that catalyze the NADPH-dependent reduction of carbonyl groups in a number of important steroid, metabolic, and prostanoid molecules.{27311,29322}  

     

    Brand:
    Cayman
    SKU:-

    Available on backorder

  • Tolmetin is a non-steroidal anti-inflammatory drug that non-selectively inhibits human COX-1 and -2 with IC50 values of 0.35 and 0.82 µM, respectively.{8427} It also inhibits aldo-keto reductases (e.g., IC50 = 2.39 µM for human aldose reductase), a family of enzymes that catalyze the NADPH-dependent reduction of carbonyl groups in a number of important steroid, metabolic, and prostanoid molecules.{27311,29322}  

     

    Brand:
    Cayman
    SKU:-

    Available on backorder

  • Tolmetin is a non-steroidal anti-inflammatory drug that non-selectively inhibits human COX-1 and -2 with IC50 values of 0.35 and 0.82 µM, respectively.{8427} It also inhibits aldo-keto reductases (e.g., IC50 = 2.39 µM for human aldose reductase), a family of enzymes that catalyze the NADPH-dependent reduction of carbonyl groups in a number of important steroid, metabolic, and prostanoid molecules.{27311,29322}  

     

    Brand:
    Cayman
    SKU:-

    Available on backorder

  • Tolmetin β-D-glucuronide is a major phase II metabolite of tolmetin (Item No. 18195).{38051} Tolmetin β-D-glucuronide has been classified into a ‘warning’ category in terms of its potential to cause idiosyncratic drug toxicity, based on its half-life in several in vitro systems.{38052}  

     

    Brand:
    Cayman
    SKU:22161 -

    Out of stock

  • Tolnaftate is a thiocarbamate antifungal agent.{53200} It is active against clinical isolates of the dermatophytes T. rubrum, T. mentagraphytes, T. verrucosum, E. floccosum, and M. canis (MIC50s = 50, 100, 6, 50, and 50 ng/ml, respectively), as well as 18 additional yeast and filamentous fungi species (MIC = 0.003-0.8 µg/ml).{17905},{25586} Tolnaftate also reduces aflatoxin production in A. parasiticus in a concentration-dependent manner.{53199} It inhibits squalene epoxidase with an IC50 value of 12.5 µg/ml in a cell-free assay.{53200}  

     

    Brand:
    Cayman
    SKU:21446 -

    Out of stock

  • Tolnaftate is a thiocarbamate antifungal agent.{53200} It is active against clinical isolates of the dermatophytes T. rubrum, T. mentagraphytes, T. verrucosum, E. floccosum, and M. canis (MIC50s = 50, 100, 6, 50, and 50 ng/ml, respectively), as well as 18 additional yeast and filamentous fungi species (MIC = 0.003-0.8 µg/ml).{17905},{25586} Tolnaftate also reduces aflatoxin production in A. parasiticus in a concentration-dependent manner.{53199} It inhibits squalene epoxidase with an IC50 value of 12.5 µg/ml in a cell-free assay.{53200}  

     

    Brand:
    Cayman
    SKU:21446 -

    Out of stock

  • Tolnaftate is a thiocarbamate antifungal agent.{53200} It is active against clinical isolates of the dermatophytes T. rubrum, T. mentagraphytes, T. verrucosum, E. floccosum, and M. canis (MIC50s = 50, 100, 6, 50, and 50 ng/ml, respectively), as well as 18 additional yeast and filamentous fungi species (MIC = 0.003-0.8 µg/ml).{17905},{25586} Tolnaftate also reduces aflatoxin production in A. parasiticus in a concentration-dependent manner.{53199} It inhibits squalene epoxidase with an IC50 value of 12.5 µg/ml in a cell-free assay.{53200}  

     

    Brand:
    Cayman
    SKU:21446 -

    Out of stock

  • Tolnaftate is a thiocarbamate antifungal agent.{53200} It is active against clinical isolates of the dermatophytes T. rubrum, T. mentagraphytes, T. verrucosum, E. floccosum, and M. canis (MIC50s = 50, 100, 6, 50, and 50 ng/ml, respectively), as well as 18 additional yeast and filamentous fungi species (MIC = 0.003-0.8 µg/ml).{17905},{25586} Tolnaftate also reduces aflatoxin production in A. parasiticus in a concentration-dependent manner.{53199} It inhibits squalene epoxidase with an IC50 value of 12.5 µg/ml in a cell-free assay.{53200}  

     

    Brand:
    Cayman
    SKU:21446 -

    Out of stock

  • Tolnaftate-d7 is intended for use as an internal standard for the quantification of tolnaftate (Item No. 21446) by GC- or LC-MS. Tolnaftate is a thiocarbamate antifungal agent.{53200} It is active against clinical isolates of the dermatophytes T. rubrum, T. mentagraphytes, T. verrucosum, E. floccosum, and M. canis (MIC50s = 50, 100, 6, 50, and 50 ng/ml, respectively), as well as 18 additional yeast and filamentous fungi species (MIC = 0.003-0.8 µg/ml).{17905,25586} Tolnaftate also reduces aflatoxin production in A. parasiticus in a concentration-dependent manner.{53199} It inhibits squalene epoxidase with an IC50 value of 12.5 µg/ml in a cell-free assay.{53200}  

     

    Brand:
    Cayman
    SKU:29048 - 1 mg

    Available on backorder

  • Tolnaftate-d7 is intended for use as an internal standard for the quantification of tolnaftate (Item No. 21446) by GC- or LC-MS. Tolnaftate is a thiocarbamate antifungal agent.{53200} It is active against clinical isolates of the dermatophytes T. rubrum, T. mentagraphytes, T. verrucosum, E. floccosum, and M. canis (MIC50s = 50, 100, 6, 50, and 50 ng/ml, respectively), as well as 18 additional yeast and filamentous fungi species (MIC = 0.003-0.8 µg/ml).{17905,25586} Tolnaftate also reduces aflatoxin production in A. parasiticus in a concentration-dependent manner.{53199} It inhibits squalene epoxidase with an IC50 value of 12.5 µg/ml in a cell-free assay.{53200}  

     

    Brand:
    Cayman
    SKU:29048 - 500 µg

    Available on backorder

  • Tolperisone is a piperidine that acts as an inhibitor of voltage-gated sodium channels with an IC50 value of 198 µM, for inhibition of peak sodium currents evoked by step depolarizations in dorsal root ganglion (DRG) neurons, in vitro.{34788} Tolperisone acts as an antispastic agent that attenuates monosynaptic, disynaptic, and polysynaptic reflux response to dorsal root stimulation in vivo. Formulations containing tolperisone are used as analgesics and muscle relaxants.  

     

    Brand:
    Cayman
    SKU:26078 - 1 g

    Available on backorder

  • Tolperisone is a piperidine that acts as an inhibitor of voltage-gated sodium channels with an IC50 value of 198 µM, for inhibition of peak sodium currents evoked by step depolarizations in dorsal root ganglion (DRG) neurons, in vitro.{34788} Tolperisone acts as an antispastic agent that attenuates monosynaptic, disynaptic, and polysynaptic reflux response to dorsal root stimulation in vivo. Formulations containing tolperisone are used as analgesics and muscle relaxants.  

     

    Brand:
    Cayman
    SKU:26078 - 250 mg

    Available on backorder

  • Tolperisone is a piperidine that acts as an inhibitor of voltage-gated sodium channels with an IC50 value of 198 µM, for inhibition of peak sodium currents evoked by step depolarizations in dorsal root ganglion (DRG) neurons, in vitro.{34788} Tolperisone acts as an antispastic agent that attenuates monosynaptic, disynaptic, and polysynaptic reflux response to dorsal root stimulation in vivo. Formulations containing tolperisone are used as analgesics and muscle relaxants.  

     

    Brand:
    Cayman
    SKU:26078 - 5 g

    Available on backorder

  • Tolperisone is a piperidine that acts as an inhibitor of voltage-gated sodium channels with an IC50 value of 198 µM, for inhibition of peak sodium currents evoked by step depolarizations in dorsal root ganglion (DRG) neurons, in vitro.{34788} Tolperisone acts as an antispastic agent that attenuates monosynaptic, disynaptic, and polysynaptic reflux response to dorsal root stimulation in vivo. Formulations containing tolperisone are used as analgesics and muscle relaxants.  

     

    Brand:
    Cayman
    SKU:26078 - 500 mg

    Available on backorder

  • Tolperisone-d10 is intended for use as an internal standard for the quantification of tolperisone by GC- or LC-MS. Tolperisone is a piperidine that acts as an inhibitor of voltage-gated sodium channels with an IC50 value of 198 µM, for inhibition of peak sodium currents evoked by step depolarizations in dorsal root ganglion (DRG) neurons, in vitro.{34788} Tolperisone acts as an antispastic agent that attenuates monosynaptic, disynaptic, and polysynaptic reflux response to dorsal root stimulation in vivo. Formulations containing tolperisone are used as analgesics and muscle relaxants.  

     

    Brand:
    Cayman
    SKU:22592 -

    Out of stock

  • Tolperisone-d10 is intended for use as an internal standard for the quantification of tolperisone by GC- or LC-MS. Tolperisone is a piperidine that acts as an inhibitor of voltage-gated sodium channels with an IC50 value of 198 µM, for inhibition of peak sodium currents evoked by step depolarizations in dorsal root ganglion (DRG) neurons, in vitro.{34788} Tolperisone acts as an antispastic agent that attenuates monosynaptic, disynaptic, and polysynaptic reflux response to dorsal root stimulation in vivo. Formulations containing tolperisone are used as analgesics and muscle relaxants.  

     

    Brand:
    Cayman
    SKU:22592 -

    Out of stock

  • Tolrestat is an aldose reductase inhibitor (IC50 = 35 nM for the bovine lens enzyme).{46762} Dietary administration of tolrestat decreases sciatic nerve galactitol accumulation in a rat model of galactosemia (ED50 = 7.3 mg/kg per day) and sciatic nerve sorbitol accumulation (ED50 = 4.8 mg/kg per day) in a rat model of diabetes induced by streptozotocin (STZ; Item No. 13104). It also decreases urinary total protein exretion in a rat model of STZ-induced diabetes when administered at a dose of 25 mg/kg per day.{46764} Topical administration of tolrestat (2 and 3% in 10 μl four times per day) decreases levels of galactitol in the lens of and inhibits cataract formation in rats fed a high-galactose diet.{46763}  

     

    Brand:
    Cayman
    SKU:29693 - 1 mg

    Available on backorder

  • Tolrestat is an aldose reductase inhibitor (IC50 = 35 nM for the bovine lens enzyme).{46762} Dietary administration of tolrestat decreases sciatic nerve galactitol accumulation in a rat model of galactosemia (ED50 = 7.3 mg/kg per day) and sciatic nerve sorbitol accumulation (ED50 = 4.8 mg/kg per day) in a rat model of diabetes induced by streptozotocin (STZ; Item No. 13104). It also decreases urinary total protein exretion in a rat model of STZ-induced diabetes when administered at a dose of 25 mg/kg per day.{46764} Topical administration of tolrestat (2 and 3% in 10 μl four times per day) decreases levels of galactitol in the lens of and inhibits cataract formation in rats fed a high-galactose diet.{46763}  

     

    Brand:
    Cayman
    SKU:29693 - 10 mg

    Available on backorder

  • Tolrestat is an aldose reductase inhibitor (IC50 = 35 nM for the bovine lens enzyme).{46762} Dietary administration of tolrestat decreases sciatic nerve galactitol accumulation in a rat model of galactosemia (ED50 = 7.3 mg/kg per day) and sciatic nerve sorbitol accumulation (ED50 = 4.8 mg/kg per day) in a rat model of diabetes induced by streptozotocin (STZ; Item No. 13104). It also decreases urinary total protein exretion in a rat model of STZ-induced diabetes when administered at a dose of 25 mg/kg per day.{46764} Topical administration of tolrestat (2 and 3% in 10 μl four times per day) decreases levels of galactitol in the lens of and inhibits cataract formation in rats fed a high-galactose diet.{46763}  

     

    Brand:
    Cayman
    SKU:29693 - 25 mg

    Available on backorder

  • Tolrestat is an aldose reductase inhibitor (IC50 = 35 nM for the bovine lens enzyme).{46762} Dietary administration of tolrestat decreases sciatic nerve galactitol accumulation in a rat model of galactosemia (ED50 = 7.3 mg/kg per day) and sciatic nerve sorbitol accumulation (ED50 = 4.8 mg/kg per day) in a rat model of diabetes induced by streptozotocin (STZ; Item No. 13104). It also decreases urinary total protein exretion in a rat model of STZ-induced diabetes when administered at a dose of 25 mg/kg per day.{46764} Topical administration of tolrestat (2 and 3% in 10 μl four times per day) decreases levels of galactitol in the lens of and inhibits cataract formation in rats fed a high-galactose diet.{46763}  

     

    Brand:
    Cayman
    SKU:29693 - 5 mg

    Available on backorder

  • Tolterodine (tartrate) is a competitive antagonist of muscarinic (M) receptors (Ki = 1.4, 2.7, 3.6, 3.1, and 2.2 nM for M1 through M5, respectively).{22772} Antagonists of muscarinic receptors, including tolterodine, are effective in treating overactive bladder symptoms.{22773}  

     

    Brand:
    Cayman
    SKU:-
  • Tolterodine (tartrate) is a competitive antagonist of muscarinic (M) receptors (Ki = 1.4, 2.7, 3.6, 3.1, and 2.2 nM for M1 through M5, respectively).{22772} Antagonists of muscarinic receptors, including tolterodine, are effective in treating overactive bladder symptoms.{22773}  

     

    Brand:
    Cayman
    SKU:-
  • Tolterodine (tartrate) is a competitive antagonist of muscarinic (M) receptors (Ki = 1.4, 2.7, 3.6, 3.1, and 2.2 nM for M1 through M5, respectively).{22772} Antagonists of muscarinic receptors, including tolterodine, are effective in treating overactive bladder symptoms.{22773}  

     

    Brand:
    Cayman
    SKU:-
  • Toltrazuril is an antiprotozoal agent that is widely used to prevent coccidia parasite infection in veterinary applications.{32761,32762,32764,32763} The effectiveness of treatment appears to depend on the coccidian species, development stage of the parasite, and level of infection.{32761,32763}  

     

    Brand:
    Cayman
    SKU:20767 -

    Available on backorder

  • Toltrazuril is an antiprotozoal agent that is widely used to prevent coccidia parasite infection in veterinary applications.{32761,32762,32764,32763} The effectiveness of treatment appears to depend on the coccidian species, development stage of the parasite, and level of infection.{32761,32763}  

     

    Brand:
    Cayman
    SKU:20767 -

    Available on backorder

  • Toltrazuril is an antiprotozoal agent that is widely used to prevent coccidia parasite infection in veterinary applications.{32761,32762,32764,32763} The effectiveness of treatment appears to depend on the coccidian species, development stage of the parasite, and level of infection.{32761,32763}  

     

    Brand:
    Cayman
    SKU:20767 -

    Available on backorder

  • Toltrazuril is an antiprotozoal agent that is widely used to prevent coccidia parasite infection in veterinary applications.{32761,32762,32764,32763} The effectiveness of treatment appears to depend on the coccidian species, development stage of the parasite, and level of infection.{32761,32763}  

     

    Brand:
    Cayman
    SKU:20767 -

    Available on backorder

  • Toltrazuril sulfone is an active metabolite of the coccidiostat toltrazuril (Item No. 20767).{46798} Toltrazuril sulfone is formed from toltrazuril via the intermediate metabolite toltrazuril sulfoxide by cytochrome P450 (CYP) enzymes, including CYP3A. It inhibits T. gondii tachyzoite production in African green monkey kidney cells when used at concentrations of 0.1, 1, and 5 µg/ml.{46799} Toltrazuril sulfone completely prevents infection with T. gondii tachyzoites in a mouse model of fatal toxoplasmosis when administered at doses of 10 or 20 mg/kg one day prior to, and daily for 10 days following, infection. It also reduces the number of infected mice in the same model when administered at a dose of 10 mg/kg for 11 days starting six days following infection. Formulations containing toltrazuril sulfone have been used in the treatment of equine protozoal myeloencephalitis (EPM) in horses.  

     

    Brand:
    Cayman
    SKU:29655 - 10 mg

    Available on backorder

  • Toltrazuril sulfone is an active metabolite of the coccidiostat toltrazuril (Item No. 20767).{46798} Toltrazuril sulfone is formed from toltrazuril via the intermediate metabolite toltrazuril sulfoxide by cytochrome P450 (CYP) enzymes, including CYP3A. It inhibits T. gondii tachyzoite production in African green monkey kidney cells when used at concentrations of 0.1, 1, and 5 µg/ml.{46799} Toltrazuril sulfone completely prevents infection with T. gondii tachyzoites in a mouse model of fatal toxoplasmosis when administered at doses of 10 or 20 mg/kg one day prior to, and daily for 10 days following, infection. It also reduces the number of infected mice in the same model when administered at a dose of 10 mg/kg for 11 days starting six days following infection. Formulations containing toltrazuril sulfone have been used in the treatment of equine protozoal myeloencephalitis (EPM) in horses.  

     

    Brand:
    Cayman
    SKU:29655 - 100 mg

    Available on backorder

  • Toltrazuril sulfone is an active metabolite of the coccidiostat toltrazuril (Item No. 20767).{46798} Toltrazuril sulfone is formed from toltrazuril via the intermediate metabolite toltrazuril sulfoxide by cytochrome P450 (CYP) enzymes, including CYP3A. It inhibits T. gondii tachyzoite production in African green monkey kidney cells when used at concentrations of 0.1, 1, and 5 µg/ml.{46799} Toltrazuril sulfone completely prevents infection with T. gondii tachyzoites in a mouse model of fatal toxoplasmosis when administered at doses of 10 or 20 mg/kg one day prior to, and daily for 10 days following, infection. It also reduces the number of infected mice in the same model when administered at a dose of 10 mg/kg for 11 days starting six days following infection. Formulations containing toltrazuril sulfone have been used in the treatment of equine protozoal myeloencephalitis (EPM) in horses.  

     

    Brand:
    Cayman
    SKU:29655 - 250 mg

    Available on backorder

  • Toltrazuril sulfone is an active metabolite of the coccidiostat toltrazuril (Item No. 20767).{46798} Toltrazuril sulfone is formed from toltrazuril via the intermediate metabolite toltrazuril sulfoxide by cytochrome P450 (CYP) enzymes, including CYP3A. It inhibits T. gondii tachyzoite production in African green monkey kidney cells when used at concentrations of 0.1, 1, and 5 µg/ml.{46799} Toltrazuril sulfone completely prevents infection with T. gondii tachyzoites in a mouse model of fatal toxoplasmosis when administered at doses of 10 or 20 mg/kg one day prior to, and daily for 10 days following, infection. It also reduces the number of infected mice in the same model when administered at a dose of 10 mg/kg for 11 days starting six days following infection. Formulations containing toltrazuril sulfone have been used in the treatment of equine protozoal myeloencephalitis (EPM) in horses.  

     

    Brand:
    Cayman
    SKU:29655 - 50 mg

    Available on backorder

  • Tolvaptan is a nonpeptide vasopressin V2 receptor antagonist (IC50 = 3 nM for rat receptor) and a diuretic agent.{31703} It is selective for V2 over V1 receptors (IC50 = 0.58 μM). Tolvaptan increases urine volume by 3-fold in rats when administered at a dose of 0.54 mg/kg. It also reduces left ventricular end-systolic volumes and improves left ventricular ejection fraction in a rat model of myocardial infarction.{43556} Formulations containing tolvaptan have been used to treat hyponatremia.  

     

    Brand:
    Cayman
    SKU:19691 -

    Available on backorder

  • Tolvaptan (Item No. 26301) is an analytical reference standard categorized as a diuretic.{31703} Formulations containing diuretics have been abused as performance-enhancing drugs and masking agents in sports doping.{33139,49040} This product is intended for use in analytical forensic applications. This product is also available as a general research tool (Item No. 19691).  

     

    Brand:
    Cayman
    SKU:26301 - 1 mg

    Available on backorder

  • Tolvaptan is a nonpeptide vasopressin V2 receptor antagonist (IC50 = 3 nM for rat receptor) and a diuretic agent.{31703} It is selective for V2 over V1 receptors (IC50 = 0.58 μM). Tolvaptan increases urine volume by 3-fold in rats when administered at a dose of 0.54 mg/kg. It also reduces left ventricular end-systolic volumes and improves left ventricular ejection fraction in a rat model of myocardial infarction.{43556} Formulations containing tolvaptan have been used to treat hyponatremia.  

     

    Brand:
    Cayman
    SKU:19691 -

    Available on backorder

  • Tolvaptan is a nonpeptide vasopressin V2 receptor antagonist (IC50 = 3 nM for rat receptor) and a diuretic agent.{31703} It is selective for V2 over V1 receptors (IC50 = 0.58 μM). Tolvaptan increases urine volume by 3-fold in rats when administered at a dose of 0.54 mg/kg. It also reduces left ventricular end-systolic volumes and improves left ventricular ejection fraction in a rat model of myocardial infarction.{43556} Formulations containing tolvaptan have been used to treat hyponatremia.  

     

    Brand:
    Cayman
    SKU:19691 -

    Available on backorder

  • Tolvaptan is a nonpeptide vasopressin V2 receptor antagonist (IC50 = 3 nM for rat receptor) and a diuretic agent.{31703} It is selective for V2 over V1 receptors (IC50 = 0.58 μM). Tolvaptan increases urine volume by 3-fold in rats when administered at a dose of 0.54 mg/kg. It also reduces left ventricular end-systolic volumes and improves left ventricular ejection fraction in a rat model of myocardial infarction.{43556} Formulations containing tolvaptan have been used to treat hyponatremia.  

     

    Brand:
    Cayman
    SKU:19691 -

    Available on backorder

  • Tolvaptan (Item No. 26301) is an analytical reference standard categorized as a diuretic.{31703} Formulations containing diuretics have been abused as performance-enhancing drugs and masking agents in sports doping.{33139,49040} This product is intended for use in analytical forensic applications. This product is also available as a general research tool (Item No. 19691).  

     

    Brand:
    Cayman
    SKU:26301 - 5 mg

    Available on backorder

  • Tolvaptan-d7 is intended for use as an internal standard for the quantification of tolvaptan (Item No. 19691) by GC- or LC-MS. Tolvaptan is a nonpeptide vasopressin V2 receptor antagonist (IC50 = 3 nM for rat receptor) and a diuretic agent.{31703} It is selective for V2 over V1 receptors (IC50 = 0.58 μM). Tolvaptan increases urine volume by 3-fold in rats when administered at a dose of 0.54 mg/kg. It also reduces left ventricular end-systolic volumes and improves left ventricular ejection fraction in a rat model of myocardial infarction.{43556} Formulations containing tolvaptan have been used to treat hyponatremia.  

     

    Brand:
    Cayman
    SKU:26453 - 1 mg

    Available on backorder

  • Tolvaptan-d7 is intended for use as an internal standard for the quantification of tolvaptan (Item No. 19691) by GC- or LC-MS. Tolvaptan is a nonpeptide vasopressin V2 receptor antagonist (IC50 = 3 nM for rat receptor) and a diuretic agent.{31703} It is selective for V2 over V1 receptors (IC50 = 0.58 μM). Tolvaptan increases urine volume by 3-fold in rats when administered at a dose of 0.54 mg/kg. It also reduces left ventricular end-systolic volumes and improves left ventricular ejection fraction in a rat model of myocardial infarction.{43556} Formulations containing tolvaptan have been used to treat hyponatremia.  

     

    Brand:
    Cayman
    SKU:26453 - 5 mg

    Available on backorder

  • Tolvaptan-d7 is intended for use as an internal standard for the quantification of tolvaptan (Item No. 19691) by GC- or LC-MS. Tolvaptan is a nonpeptide vasopressin V2 receptor antagonist (IC50 = 3 nM for rat receptor) and a diuretic agent.{31703} It is selective for V2 over V1 receptors (IC50 = 0.58 μM). Tolvaptan increases urine volume by 3-fold in rats when administered at a dose of 0.54 mg/kg. It also reduces left ventricular end-systolic volumes and improves left ventricular ejection fraction in a rat model of myocardial infarction.{43556} Formulations containing tolvaptan have been used to treat hyponatremia.  

     

    Brand:
    Cayman
    SKU:26453 - 500 µg

    Available on backorder

  • Tomatidine is a steroidal alkaloid that has been found in the skins and leaves of tomatoes.{27622} It suppresses NF-κB signaling in LPS-stimulated macrophages, blocking induced expression of inducible nitric oxide synthase (iNOS) and COX-2. Tomatidine inhibits acid sphingomyelinase activity by 84.2% when used at a concentration of 10 mM.{26583} It also has antibacterial properties, preferentially blocking the replication of S. aureus variants that are pathogenic in cystic fibrosis over normal strains (MICs = 0.12 and >16 µg/ml, respectively).{27624} It prevents skeletal muscle atrophy associated with fasting or spinal cord injury in mice.{27625} Tomatidine has also been used as a negative control for cyclopamine (Item No. 11321) in studies involving signaling mediated by the hedgehog pathway.{27623}  

     

    Brand:
    Cayman
    SKU:-

    Out of stock

  • Tomatidine is a steroidal alkaloid that has been found in the skins and leaves of tomatoes.{27622} It suppresses NF-κB signaling in LPS-stimulated macrophages, blocking induced expression of inducible nitric oxide synthase (iNOS) and COX-2. Tomatidine inhibits acid sphingomyelinase activity by 84.2% when used at a concentration of 10 mM.{26583} It also has antibacterial properties, preferentially blocking the replication of S. aureus variants that are pathogenic in cystic fibrosis over normal strains (MICs = 0.12 and >16 µg/ml, respectively).{27624} It prevents skeletal muscle atrophy associated with fasting or spinal cord injury in mice.{27625} Tomatidine has also been used as a negative control for cyclopamine (Item No. 11321) in studies involving signaling mediated by the hedgehog pathway.{27623}  

     

    Brand:
    Cayman
    SKU:-

    Out of stock

  • Tomatidine is a steroidal alkaloid that has been found in the skins and leaves of tomatoes.{27622} It suppresses NF-κB signaling in LPS-stimulated macrophages, blocking induced expression of inducible nitric oxide synthase (iNOS) and COX-2. Tomatidine inhibits acid sphingomyelinase activity by 84.2% when used at a concentration of 10 mM.{26583} It also has antibacterial properties, preferentially blocking the replication of S. aureus variants that are pathogenic in cystic fibrosis over normal strains (MICs = 0.12 and >16 µg/ml, respectively).{27624} It prevents skeletal muscle atrophy associated with fasting or spinal cord injury in mice.{27625} Tomatidine has also been used as a negative control for cyclopamine (Item No. 11321) in studies involving signaling mediated by the hedgehog pathway.{27623}  

     

    Brand:
    Cayman
    SKU:-

    Out of stock

  • Tomatidine is a steroidal alkaloid that has been found in the skins and leaves of tomatoes.{27622} It suppresses NF-κB signaling in LPS-stimulated macrophages, blocking induced expression of inducible nitric oxide synthase (iNOS) and COX-2. Tomatidine inhibits acid sphingomyelinase activity by 84.2% when used at a concentration of 10 mM.{26583} It also has antibacterial properties, preferentially blocking the replication of S. aureus variants that are pathogenic in cystic fibrosis over normal strains (MICs = 0.12 and >16 µg/ml, respectively).{27624} It prevents skeletal muscle atrophy associated with fasting or spinal cord injury in mice.{27625} Tomatidine has also been used as a negative control for cyclopamine (Item No. 11321) in studies involving signaling mediated by the hedgehog pathway.{27623}  

     

    Brand:
    Cayman
    SKU:-

    Out of stock

  • Tonabersat is an anti-migraine agent.{40037,40034} It binds to connexin43 hemichannels and inhibits ATP release in vitro during injury and reperfusion in a dose-dependent manner.{40033} This inhibition blocks trigeminal ganglion neuronal-satellite glial cell signaling and cortical spreading depression, a trigger of migraine pain.{40033,40034,40035} In vivo, tonabersat (10 mg/kg) increases the seizure threshold in maximal electroshock seizure threshold (MEST) mice and rats (143 and 1192%, respectively) and completely blocks neurogenic plasma extravasation, a marker of migraine pain, in a rat trigeminal nerve migraine model.{40036} Formulations containing tonabersat are in clinical trials for acute treatment of migraine.{40037}  

     

    Brand:
    Cayman
    SKU:19796 -

    Available on backorder

  • Tonabersat is an anti-migraine agent.{40037,40034} It binds to connexin43 hemichannels and inhibits ATP release in vitro during injury and reperfusion in a dose-dependent manner.{40033} This inhibition blocks trigeminal ganglion neuronal-satellite glial cell signaling and cortical spreading depression, a trigger of migraine pain.{40033,40034,40035} In vivo, tonabersat (10 mg/kg) increases the seizure threshold in maximal electroshock seizure threshold (MEST) mice and rats (143 and 1192%, respectively) and completely blocks neurogenic plasma extravasation, a marker of migraine pain, in a rat trigeminal nerve migraine model.{40036} Formulations containing tonabersat are in clinical trials for acute treatment of migraine.{40037}  

     

    Brand:
    Cayman
    SKU:19796 -

    Available on backorder

  • Tonabersat is an anti-migraine agent.{40037,40034} It binds to connexin43 hemichannels and inhibits ATP release in vitro during injury and reperfusion in a dose-dependent manner.{40033} This inhibition blocks trigeminal ganglion neuronal-satellite glial cell signaling and cortical spreading depression, a trigger of migraine pain.{40033,40034,40035} In vivo, tonabersat (10 mg/kg) increases the seizure threshold in maximal electroshock seizure threshold (MEST) mice and rats (143 and 1192%, respectively) and completely blocks neurogenic plasma extravasation, a marker of migraine pain, in a rat trigeminal nerve migraine model.{40036} Formulations containing tonabersat are in clinical trials for acute treatment of migraine.{40037}  

     

    Brand:
    Cayman
    SKU:19796 -

    Available on backorder

  • Tonabersat is an anti-migraine agent.{40037,40034} It binds to connexin43 hemichannels and inhibits ATP release in vitro during injury and reperfusion in a dose-dependent manner.{40033} This inhibition blocks trigeminal ganglion neuronal-satellite glial cell signaling and cortical spreading depression, a trigger of migraine pain.{40033,40034,40035} In vivo, tonabersat (10 mg/kg) increases the seizure threshold in maximal electroshock seizure threshold (MEST) mice and rats (143 and 1192%, respectively) and completely blocks neurogenic plasma extravasation, a marker of migraine pain, in a rat trigeminal nerve migraine model.{40036} Formulations containing tonabersat are in clinical trials for acute treatment of migraine.{40037}  

     

    Brand:
    Cayman
    SKU:19796 -

    Available on backorder

  • Topiramate is a sugar sulfamate with anticonvulsant activity.{18290} It inhibits carbonic anhydrase in intact human erythrocytes (Ki = ~200 μM), as well as blocks sodium and calcium channels and kainate-induced currents in vitro.{18290,32575,48075} It also increases GABAA receptor-mediated chloride ion flux.{48075} Topiramate inhibits hind-limb tonic-extensor seizures in the maximal electroshock seizure test in mice (ED50 = 39 mg/kg, p.o.).{18290} Formulations containing topiramate have been used in the treatment of epilepsy and prophylaxis of migraine headaches.  

     

    Brand:
    Cayman
    SKU:-
  • Topiramate is a sugar sulfamate with anticonvulsant activity.{18290} It inhibits carbonic anhydrase in intact human erythrocytes (Ki = ~200 μM), as well as blocks sodium and calcium channels and kainate-induced currents in vitro.{18290,32575,48075} It also increases GABAA receptor-mediated chloride ion flux.{48075} Topiramate inhibits hind-limb tonic-extensor seizures in the maximal electroshock seizure test in mice (ED50 = 39 mg/kg, p.o.).{18290} Formulations containing topiramate have been used in the treatment of epilepsy and prophylaxis of migraine headaches.  

     

    Brand:
    Cayman
    SKU:-
  • Topiramate is a sugar sulfamate with anticonvulsant activity.{18290} It inhibits carbonic anhydrase in intact human erythrocytes (Ki = ~200 μM), as well as blocks sodium and calcium channels and kainate-induced currents in vitro.{18290,32575,48075} It also increases GABAA receptor-mediated chloride ion flux.{48075} Topiramate inhibits hind-limb tonic-extensor seizures in the maximal electroshock seizure test in mice (ED50 = 39 mg/kg, p.o.).{18290} Formulations containing topiramate have been used in the treatment of epilepsy and prophylaxis of migraine headaches.  

     

    Brand:
    Cayman
    SKU:-
  • Topiramate is a sugar sulfamate with anticonvulsant activity.{18290} It inhibits carbonic anhydrase in intact human erythrocytes (Ki = ~200 μM), as well as blocks sodium and calcium channels and kainate-induced currents in vitro.{18290,32575,48075} It also increases GABAA receptor-mediated chloride ion flux.{48075} Topiramate inhibits hind-limb tonic-extensor seizures in the maximal electroshock seizure test in mice (ED50 = 39 mg/kg, p.o.).{18290} Formulations containing topiramate have been used in the treatment of epilepsy and prophylaxis of migraine headaches.  

     

    Brand:
    Cayman
    SKU:-
  • Topiramate-d12 is intended for use as an internal standard for the quantification of topiramate (Item No. 13623) by GC- or LC-MS. Topiramate is a sugar sulfamate with anticonvulsant activity.{18290} It inhibits carbonic anhydrase in intact human erythrocytes (Ki = ~200 μM), as well as blocks sodium and calcium channels and kainate-induced currents in vitro.{18290,32575,48075} It also increases GABAA receptor-mediated chloride ion flux.{48075} Topiramate inhibits hind-limb tonic-extensor seizures in the maximal electroshock seizure test in mice (ED50 = 39 mg/kg, p.o.).{18290} Formulations containing topiramate have been used in the treatment of epilepsy and prophylaxis of migraine headaches.  

     

    Brand:
    Cayman
    SKU:26443 - 1 mg

    Available on backorder

  • Topiramate-d12 is intended for use as an internal standard for the quantification of topiramate (Item No. 13623) by GC- or LC-MS. Topiramate is a sugar sulfamate with anticonvulsant activity.{18290} It inhibits carbonic anhydrase in intact human erythrocytes (Ki = ~200 μM), as well as blocks sodium and calcium channels and kainate-induced currents in vitro.{18290,32575,48075} It also increases GABAA receptor-mediated chloride ion flux.{48075} Topiramate inhibits hind-limb tonic-extensor seizures in the maximal electroshock seizure test in mice (ED50 = 39 mg/kg, p.o.).{18290} Formulations containing topiramate have been used in the treatment of epilepsy and prophylaxis of migraine headaches.  

     

    Brand:
    Cayman
    SKU:26443 - 10 mg

    Available on backorder

  • Topiramate-d12 is intended for use as an internal standard for the quantification of topiramate (Item No. 13623) by GC- or LC-MS. Topiramate is a sugar sulfamate with anticonvulsant activity.{18290} It inhibits carbonic anhydrase in intact human erythrocytes (Ki = ~200 μM), as well as blocks sodium and calcium channels and kainate-induced currents in vitro.{18290,32575,48075} It also increases GABAA receptor-mediated chloride ion flux.{48075} Topiramate inhibits hind-limb tonic-extensor seizures in the maximal electroshock seizure test in mice (ED50 = 39 mg/kg, p.o.).{18290} Formulations containing topiramate have been used in the treatment of epilepsy and prophylaxis of migraine headaches.  

     

    Brand:
    Cayman
    SKU:26443 - 5 mg

    Available on backorder

  • Topiramate-d12 is intended for use as an internal standard for the quantification of topiramate (Item No. 13623) by GC- or LC-MS. Topiramate is a sugar sulfamate with anticonvulsant activity.{18290} It inhibits carbonic anhydrase in intact human erythrocytes (Ki = ~200 μM), as well as blocks sodium and calcium channels and kainate-induced currents in vitro.{18290,32575,48075} It also increases GABAA receptor-mediated chloride ion flux.{48075} Topiramate inhibits hind-limb tonic-extensor seizures in the maximal electroshock seizure test in mice (ED50 = 39 mg/kg, p.o.).{18290} Formulations containing topiramate have been used in the treatment of epilepsy and prophylaxis of migraine headaches.  

     

    Brand:
    Cayman
    SKU:26443 - 500 µg

    Available on backorder

  • Topiroxostat is an inhibitor of xanthine oxidoreductase (IC50 = 5.3 nM), an enzyme that converts xanthine to urate.{33356} Formulations containing topiroxostat are effective in vivo, lowering urate levels in the serum of patients with hyperuricemia.{33354} In rats, but not primates, topiroxostat treatment results in the formation of xanthine crystals, resulting in nephritis.{33357,33358} Topiroxostat also inhibits ATP-binding cassette transporter G2 (ABCG2; IC50 = 0.18 µM), a high-capacity urate transporter that functions in both renal and extrarenal urate secretion.{33355}  

     

    Brand:
    Cayman
    SKU:21267 -

    Out of stock

  • Topiroxostat is an inhibitor of xanthine oxidoreductase (IC50 = 5.3 nM), an enzyme that converts xanthine to urate.{33356} Formulations containing topiroxostat are effective in vivo, lowering urate levels in the serum of patients with hyperuricemia.{33354} In rats, but not primates, topiroxostat treatment results in the formation of xanthine crystals, resulting in nephritis.{33357,33358} Topiroxostat also inhibits ATP-binding cassette transporter G2 (ABCG2; IC50 = 0.18 µM), a high-capacity urate transporter that functions in both renal and extrarenal urate secretion.{33355}  

     

    Brand:
    Cayman
    SKU:21267 -

    Out of stock

  • Topiroxostat is an inhibitor of xanthine oxidoreductase (IC50 = 5.3 nM), an enzyme that converts xanthine to urate.{33356} Formulations containing topiroxostat are effective in vivo, lowering urate levels in the serum of patients with hyperuricemia.{33354} In rats, but not primates, topiroxostat treatment results in the formation of xanthine crystals, resulting in nephritis.{33357,33358} Topiroxostat also inhibits ATP-binding cassette transporter G2 (ABCG2; IC50 = 0.18 µM), a high-capacity urate transporter that functions in both renal and extrarenal urate secretion.{33355}  

     

    Brand:
    Cayman
    SKU:21267 -

    Out of stock

  • Topiroxostat is an inhibitor of xanthine oxidoreductase (IC50 = 5.3 nM), an enzyme that converts xanthine to urate.{33356} Formulations containing topiroxostat are effective in vivo, lowering urate levels in the serum of patients with hyperuricemia.{33354} In rats, but not primates, topiroxostat treatment results in the formation of xanthine crystals, resulting in nephritis.{33357,33358} Topiroxostat also inhibits ATP-binding cassette transporter G2 (ABCG2; IC50 = 0.18 µM), a high-capacity urate transporter that functions in both renal and extrarenal urate secretion.{33355}  

     

    Brand:
    Cayman
    SKU:21267 -

    Out of stock

  • Topotecan is an inhibitor of DNA topoisomerase I and a derivative of the DNA topoisomerase I inhibitor camptothecin (Item No. 11694).{21114,21115,22689} Topotecan inhibits DNA topoisomerase I in human MCF-7 breast and DU-145 prostate cancer cells with IC50 values of 13 and 2 nM, respectively, in a cell-based luciferase reporter assay.{42991} Topotecan induces cytotoxicity and DNA damage in HT-29 human colon adenocarcinoma cells with (IC50s = 33 and 280 nM, respectively.{21114} Formulations containing topotecan have been used in the treatment of small-cell lung cancer.  

     

    Brand:
    Cayman
    SKU:-
  • Topotecan is an inhibitor of DNA topoisomerase I and a derivative of the DNA topoisomerase I inhibitor camptothecin (Item No. 11694).{21114,21115,22689} Topotecan inhibits DNA topoisomerase I in human MCF-7 breast and DU-145 prostate cancer cells with IC50 values of 13 and 2 nM, respectively, in a cell-based luciferase reporter assay.{42991} Topotecan induces cytotoxicity and DNA damage in HT-29 human colon adenocarcinoma cells with (IC50s = 33 and 280 nM, respectively.{21114} Formulations containing topotecan have been used in the treatment of small-cell lung cancer.  

     

    Brand:
    Cayman
    SKU:-
  • Topotecan is an inhibitor of DNA topoisomerase I and a derivative of the DNA topoisomerase I inhibitor camptothecin (Item No. 11694).{21114,21115,22689} Topotecan inhibits DNA topoisomerase I in human MCF-7 breast and DU-145 prostate cancer cells with IC50 values of 13 and 2 nM, respectively, in a cell-based luciferase reporter assay.{42991} Topotecan induces cytotoxicity and DNA damage in HT-29 human colon adenocarcinoma cells with (IC50s = 33 and 280 nM, respectively.{21114} Formulations containing topotecan have been used in the treatment of small-cell lung cancer.  

     

    Brand:
    Cayman
    SKU:-
  • Topotecan is an inhibitor of DNA topoisomerase I and a derivative of the DNA topoisomerase I inhibitor camptothecin (Item No. 11694).{21114,21115,22689} Topotecan inhibits DNA topoisomerase I in human MCF-7 breast and DU-145 prostate cancer cells with IC50 values of 13 and 2 nM, respectively, in a cell-based luciferase reporter assay.{42991} Topotecan induces cytotoxicity and DNA damage in HT-29 human colon adenocarcinoma cells with (IC50s = 33 and 280 nM, respectively.{21114} Formulations containing topotecan have been used in the treatment of small-cell lung cancer.  

     

    Brand:
    Cayman
    SKU:-
  • Topotecan-d6 is intended for use as an internal standard for the quantification of topotecan (Item No. 14129) by GC- or LC-MS. Topotecan is an inhibitor of DNA topoisomerase I and a derivative of the DNA topoisomerase I inhibitor camptothecin (Item No. 11694).{21114,21115,22689} Topotecan inhibits DNA topoisomerase I in human MCF-7 breast and DU145 prostate cancer cells with IC50 values of 13 and 2 nM, respectively, in a cell-based luciferase reporter assay.{42991} Topotecan induces cytotoxicity and DNA damage in HT-29 human colon adenocarcinoma cells (IC50s = 33 and 280 nM, respectively).{21114} Formulations containing topotecan have been used in the treatment of small-cell lung cancer.  

     

    Brand:
    Cayman
    SKU:29082 - 1 mg

    Available on backorder

  • Topotecan-d6 is intended for use as an internal standard for the quantification of topotecan (Item No. 14129) by GC- or LC-MS. Topotecan is an inhibitor of DNA topoisomerase I and a derivative of the DNA topoisomerase I inhibitor camptothecin (Item No. 11694).{21114,21115,22689} Topotecan inhibits DNA topoisomerase I in human MCF-7 breast and DU145 prostate cancer cells with IC50 values of 13 and 2 nM, respectively, in a cell-based luciferase reporter assay.{42991} Topotecan induces cytotoxicity and DNA damage in HT-29 human colon adenocarcinoma cells (IC50s = 33 and 280 nM, respectively).{21114} Formulations containing topotecan have been used in the treatment of small-cell lung cancer.  

     

    Brand:
    Cayman
    SKU:29082 - 500 µg

    Available on backorder

  • Torasemide (Item No. 21312) is an analytical reference standard categorized as a diuretic.{26628,33155,33139} Diuretics, including torasemide, have been abused as performance-enhancing drugs and masking agents in doping in sports.{33139} This product is intended for research and forensic applications.  

     

    Brand:
    Cayman
    SKU:21312 -

    Out of stock

  • Torasemide (Item No. 21312) is an analytical reference standard categorized as a diuretic.{26628,33155,33139} Diuretics, including torasemide, have been abused as performance-enhancing drugs and masking agents in doping in sports.{33139} This product is intended for research and forensic applications.  

     

    Brand:
    Cayman
    SKU:21312 -

    Out of stock

  • Torasemide (Item No. 21312) is an analytical reference standard categorized as a diuretic.{26628,33155,33139} Diuretics, including torasemide, have been abused as performance-enhancing drugs and masking agents in doping in sports.{33139} This product is intended for research and forensic applications.  

     

    Brand:
    Cayman
    SKU:21312 -

    Out of stock

  • Torasemide-d7 is intended for use as an internal standard for the quantification of torasemide by GC- or LC-MS. Torasemide is a loop diuretic.{33155} In vivo, torasemide (6 mg/kg) increases fractional potassium, sodium, and chloride excretion and increases urine flow in rats. Formulations containing torsemide have been used to treat edema associated with congestive heart failure, kidney disease, and liver disease, as well as high blood pressure.  

     

    Brand:
    Cayman
    SKU:26790 - 1 mg

    Available on backorder

  • Torasemide-d7 is intended for use as an internal standard for the quantification of torasemide by GC- or LC-MS. Torasemide is a loop diuretic.{33155} In vivo, torasemide (6 mg/kg) increases fractional potassium, sodium, and chloride excretion and increases urine flow in rats. Formulations containing torsemide have been used to treat edema associated with congestive heart failure, kidney disease, and liver disease, as well as high blood pressure.  

     

    Brand:
    Cayman
    SKU:26790 - 5 mg

    Available on backorder

  • Torasemide-d7 is intended for use as an internal standard for the quantification of torasemide by GC- or LC-MS. Torasemide is a loop diuretic.{33155} In vivo, torasemide (6 mg/kg) increases fractional potassium, sodium, and chloride excretion and increases urine flow in rats. Formulations containing torsemide have been used to treat edema associated with congestive heart failure, kidney disease, and liver disease, as well as high blood pressure.  

     

    Brand:
    Cayman
    SKU:26790 - 500 µg

    Available on backorder

  • Cholesteryl ester transfer protein (CETP) catalyzes the exchange of cholesteryl esters from high-density lipoprotein (HDL) cholesterol to apolipoprotein B-containing lipoproteins, including very low-density lipoprotein (VLDL) and LDL.{22539} Torcetrapib is an inhibitor of CETP activity (IC50 = 50 nM) that raises HDL cholesterol and reduces LDL cholesterol levels by forming a nonproductive complex between CETP and HDL.{14626} Although torcetrapib produced consistent antiatherogenic effects in rabbits, clinical trials of torcetrapib were terminated early due to deleterious hypertensive effects.{22539, 22538} PDGFR, HGFR (c-Met), IL-2 receptor, and ErbB1- tyrosine kinase have subsequently been identified as direct off-targets of this compound.{22540}  

     

    Brand:
    Cayman
    SKU:-
  • Cholesteryl ester transfer protein (CETP) catalyzes the exchange of cholesteryl esters from high-density lipoprotein (HDL) cholesterol to apolipoprotein B-containing lipoproteins, including very low-density lipoprotein (VLDL) and LDL.{22539} Torcetrapib is an inhibitor of CETP activity (IC50 = 50 nM) that raises HDL cholesterol and reduces LDL cholesterol levels by forming a nonproductive complex between CETP and HDL.{14626} Although torcetrapib produced consistent antiatherogenic effects in rabbits, clinical trials of torcetrapib were terminated early due to deleterious hypertensive effects.{22539, 22538} PDGFR, HGFR (c-Met), IL-2 receptor, and ErbB1- tyrosine kinase have subsequently been identified as direct off-targets of this compound.{22540}  

     

    Brand:
    Cayman
    SKU:-
  • Cholesteryl ester transfer protein (CETP) catalyzes the exchange of cholesteryl esters from high-density lipoprotein (HDL) cholesterol to apolipoprotein B-containing lipoproteins, including very low-density lipoprotein (VLDL) and LDL.{22539} Torcetrapib is an inhibitor of CETP activity (IC50 = 50 nM) that raises HDL cholesterol and reduces LDL cholesterol levels by forming a nonproductive complex between CETP and HDL.{14626} Although torcetrapib produced consistent antiatherogenic effects in rabbits, clinical trials of torcetrapib were terminated early due to deleterious hypertensive effects.{22539, 22538} PDGFR, HGFR (c-Met), IL-2 receptor, and ErbB1- tyrosine kinase have subsequently been identified as direct off-targets of this compound.{22540}  

     

    Brand:
    Cayman
    SKU:-
  • Toremifene (citrate) is an orally bioavailable selective estrogen receptor modulator (SERM) that evokes tissue-dependent effects similar to that of tamoxifen (Item No. 13258).{23588} It has been shown to block estrogen-stimulated growth of MCF-7 breast cancer cells grown in tissue culture, to inhibit ovariectomy-induced bone loss in rats, and to stimulate endometrial growth similar to that of tamoxifen.{23588}  

     

    Brand:
    Cayman
    SKU:20854 -

    Out of stock

  • Toremifene (citrate) is an orally bioavailable selective estrogen receptor modulator (SERM) that evokes tissue-dependent effects similar to that of tamoxifen (Item No. 13258).{23588} It has been shown to block estrogen-stimulated growth of MCF-7 breast cancer cells grown in tissue culture, to inhibit ovariectomy-induced bone loss in rats, and to stimulate endometrial growth similar to that of tamoxifen.{23588}  

     

    Brand:
    Cayman
    SKU:20854 -

    Out of stock

  • Toremifene (citrate) is an orally bioavailable selective estrogen receptor modulator (SERM) that evokes tissue-dependent effects similar to that of tamoxifen (Item No. 13258).{23588} It has been shown to block estrogen-stimulated growth of MCF-7 breast cancer cells grown in tissue culture, to inhibit ovariectomy-induced bone loss in rats, and to stimulate endometrial growth similar to that of tamoxifen.{23588}  

     

    Brand:
    Cayman
    SKU:20854 -

    Out of stock

  • Toremifene (citrate) is an orally bioavailable selective estrogen receptor modulator (SERM) that evokes tissue-dependent effects similar to that of tamoxifen (Item No. 13258).{23588} It has been shown to block estrogen-stimulated growth of MCF-7 breast cancer cells grown in tissue culture, to inhibit ovariectomy-induced bone loss in rats, and to stimulate endometrial growth similar to that of tamoxifen.{23588}  

     

    Brand:
    Cayman
    SKU:20854 -

    Out of stock

  • Torin 1 is a potent and selective inhibitor of mTOR (IC50 = 2 and 10 nM for mTORC1 and mTORC2, respectively).{19694,19693} It shows over 100-fold selectivity for mTOR over PI3Kα and other PI3K-like kinases, including ATM, DNA-PK, and hVps34, as well as 450 other protein kinases.{19694,19693} Torin 1, is efficacious at a dose of 20 mg/kg in inhibiting downstream effectors of mTOR in mice.{19693}  

     

    Brand:
    Cayman
    SKU:10997 - 10 mg

    Available on backorder

  • Torin 1 is a potent and selective inhibitor of mTOR (IC50 = 2 and 10 nM for mTORC1 and mTORC2, respectively).{19694,19693} It shows over 100-fold selectivity for mTOR over PI3Kα and other PI3K-like kinases, including ATM, DNA-PK, and hVps34, as well as 450 other protein kinases.{19694,19693} Torin 1, is efficacious at a dose of 20 mg/kg in inhibiting downstream effectors of mTOR in mice.{19693}  

     

    Brand:
    Cayman
    SKU:10997 - 25 mg

    Available on backorder

  • Torin 1 is a potent and selective inhibitor of mTOR (IC50 = 2 and 10 nM for mTORC1 and mTORC2, respectively).{19694,19693} It shows over 100-fold selectivity for mTOR over PI3Kα and other PI3K-like kinases, including ATM, DNA-PK, and hVps34, as well as 450 other protein kinases.{19694,19693} Torin 1, is efficacious at a dose of 20 mg/kg in inhibiting downstream effectors of mTOR in mice.{19693}  

     

    Brand:
    Cayman
    SKU:10997 - 50 mg

    Available on backorder

  • Torin 2 is a potent and selective inhibitor of cellular mTOR activity (EC50 = 0.3 nM).{22455} It shows more than 800-fold selectivity for mTOR over PI3K (EC50 = 200 nM) and greater than 100-fold binding selectivity relative to 440 other protein kinases.{22455} Torin 2 has significantly improved bioavailability (54%), metabolic stability, and plasma exposure compared to torin 1 (Item No. 10997).{22455,19694}  

     

    Brand:
    Cayman
    SKU:-
  • Torin 2 is a potent and selective inhibitor of cellular mTOR activity (EC50 = 0.3 nM).{22455} It shows more than 800-fold selectivity for mTOR over PI3K (EC50 = 200 nM) and greater than 100-fold binding selectivity relative to 440 other protein kinases.{22455} Torin 2 has significantly improved bioavailability (54%), metabolic stability, and plasma exposure compared to torin 1 (Item No. 10997).{22455,19694}  

     

    Brand:
    Cayman
    SKU:-
  • Torin 2 is a potent and selective inhibitor of cellular mTOR activity (EC50 = 0.3 nM).{22455} It shows more than 800-fold selectivity for mTOR over PI3K (EC50 = 200 nM) and greater than 100-fold binding selectivity relative to 440 other protein kinases.{22455} Torin 2 has significantly improved bioavailability (54%), metabolic stability, and plasma exposure compared to torin 1 (Item No. 10997).{22455,19694}  

     

    Brand:
    Cayman
    SKU:-
  • Tosedostat is an inhibitor of aminopeptidases (IC50s = 100, 150, and 220 nM for LAP, PUSA, and aminopeptidase N, respectively).{37251} It inhibits proliferation of human leukemia cell lines in vitro irrespective of p53, PTEN, or K-RAS mutational status (IC50s = 10-770 nM). Tosedostat induces up-regulation of genes in amino acid transport and metabolic pathways and inhibits phosphorylation of mammalian target of rapamycin (mTOR) substrates in HL-60 cells, markers of amino acid depletion. In vivo, tosedostat (100 mg/kg) reduces total tumor burden and the number of spontaneous metastases in a mouse MDA-MB-435 xenograft model. Formulations containing tosedostat are under clinical investigation for the treatment of myeloid leukemia.  

     

    Brand:
    Cayman
    SKU:23395 - 1 mg

    Available on backorder

  • Tosedostat is an inhibitor of aminopeptidases (IC50s = 100, 150, and 220 nM for LAP, PUSA, and aminopeptidase N, respectively).{37251} It inhibits proliferation of human leukemia cell lines in vitro irrespective of p53, PTEN, or K-RAS mutational status (IC50s = 10-770 nM). Tosedostat induces up-regulation of genes in amino acid transport and metabolic pathways and inhibits phosphorylation of mammalian target of rapamycin (mTOR) substrates in HL-60 cells, markers of amino acid depletion. In vivo, tosedostat (100 mg/kg) reduces total tumor burden and the number of spontaneous metastases in a mouse MDA-MB-435 xenograft model. Formulations containing tosedostat are under clinical investigation for the treatment of myeloid leukemia.  

     

    Brand:
    Cayman
    SKU:23395 - 5 mg

    Available on backorder

  • Tosufloxacin is a fluoroquinolone antibiotic. It has activity against diverse aerobic and anaerobic bacteria in vitro.{33732,33733} Tosufloxacin is also effective against bacterial persisters, showing significant activity against S. aureus and uropathogenic E. coli persisters.{33734,33735} As with many other quinolones, tosufloxacin use can be associated with significant side effects.{33736}  

     

    Brand:
    Cayman
    SKU:21427 -

    Out of stock

  • Tosufloxacin is a fluoroquinolone antibiotic. It has activity against diverse aerobic and anaerobic bacteria in vitro.{33732,33733} Tosufloxacin is also effective against bacterial persisters, showing significant activity against S. aureus and uropathogenic E. coli persisters.{33734,33735} As with many other quinolones, tosufloxacin use can be associated with significant side effects.{33736}  

     

    Brand:
    Cayman
    SKU:21427 -

    Out of stock

  • Tosufloxacin is a fluoroquinolone antibiotic. It has activity against diverse aerobic and anaerobic bacteria in vitro.{33732,33733} Tosufloxacin is also effective against bacterial persisters, showing significant activity against S. aureus and uropathogenic E. coli persisters.{33734,33735} As with many other quinolones, tosufloxacin use can be associated with significant side effects.{33736}  

     

    Brand:
    Cayman
    SKU:21427 -

    Out of stock

  • Tosufloxacin is a fluoroquinolone antibiotic. It has activity against diverse aerobic and anaerobic bacteria in vitro.{33732,33733} Tosufloxacin is also effective against bacterial persisters, showing significant activity against S. aureus and uropathogenic E. coli persisters.{33734,33735} As with many other quinolones, tosufloxacin use can be associated with significant side effects.{33736}  

     

    Brand:
    Cayman
    SKU:21427 -

    Out of stock

  • Tosyl phenylalanyl chloromethyl ketone (TPCK) is an irreversible inhibitor of chymotrypsin-like proteases that has been shown to affect cell proliferation, apoptosis, and tumorigenesis.{33079} It can disrupt PDK1 signaling to the AGC kinases, Akt, S6K1, and RSK, as well as MSK1 and MSK2.{33078} TPCK also inhibits superoxide production and suppresses neutrophil respiratory burst.{33080}  

     

    Brand:
    Cayman
    SKU:20166 -

    Available on backorder

  • Tosyl phenylalanyl chloromethyl ketone (TPCK) is an irreversible inhibitor of chymotrypsin-like proteases that has been shown to affect cell proliferation, apoptosis, and tumorigenesis.{33079} It can disrupt PDK1 signaling to the AGC kinases, Akt, S6K1, and RSK, as well as MSK1 and MSK2.{33078} TPCK also inhibits superoxide production and suppresses neutrophil respiratory burst.{33080}  

     

    Brand:
    Cayman
    SKU:20166 -

    Available on backorder

  • Tosyl phenylalanyl chloromethyl ketone (TPCK) is an irreversible inhibitor of chymotrypsin-like proteases that has been shown to affect cell proliferation, apoptosis, and tumorigenesis.{33079} It can disrupt PDK1 signaling to the AGC kinases, Akt, S6K1, and RSK, as well as MSK1 and MSK2.{33078} TPCK also inhibits superoxide production and suppresses neutrophil respiratory burst.{33080}  

     

    Brand:
    Cayman
    SKU:20166 -

    Available on backorder

  • Tosyl phenylalanyl chloromethyl ketone (TPCK) is an irreversible inhibitor of chymotrypsin-like proteases that has been shown to affect cell proliferation, apoptosis, and tumorigenesis.{33079} It can disrupt PDK1 signaling to the AGC kinases, Akt, S6K1, and RSK, as well as MSK1 and MSK2.{33078} TPCK also inhibits superoxide production and suppresses neutrophil respiratory burst.{33080}  

     

    Brand:
    Cayman
    SKU:20166 -

    Available on backorder

  • Tosyllysine chloromethylketone (TLCK) is an active site-directed agent that inhibits serine proteinases with trypsin-like activity. TLCK may also act non-selectively with thiol groups and thereby inhibit cysteine proteinases and other enzymes.{13825} To prevent proteolytic degradation, TLCK may be used in protein purification protocols.{16785} TLCK selectively inactiviates clostripain obtained from C. histolyticum.{16786}  

     

    Brand:
    Cayman
    SKU:-
  • Tosyllysine chloromethylketone (TLCK) is an active site-directed agent that inhibits serine proteinases with trypsin-like activity. TLCK may also act non-selectively with thiol groups and thereby inhibit cysteine proteinases and other enzymes.{13825} To prevent proteolytic degradation, TLCK may be used in protein purification protocols.{16785} TLCK selectively inactiviates clostripain obtained from C. histolyticum.{16786}  

     

    Brand:
    Cayman
    SKU:-