Cayman

Showing 42151–42300 of 45550 results

  • Antigen: synthetic peptide within the region of human TIP60 amino acids 480-530 • Host: rabbit • Cross Reactivity: (+) human (isoform CRA_b), chimpanzee, orangutan, equine, canine, mouse, ovine, rat, opossum, zebrafish, and Xenopus TIP60 • Application(s): IHC and WB • TIP60 belongs to the MYST family of HATs. It is a catalytic subunit of the NuA4 HAT complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A.  

     

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    Cayman
    SKU:13789- 1 ea

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  • Antigen: synthetic peptide within the region of human TIP60 amino acids 480-530 • Host: rabbit • Cross Reactivity: (+) human (isoform CRA_b), chimpanzee, orangutan, equine, canine, mouse, ovine, rat, opossum, zebrafish, and Xenopus TIP60 • Application(s): IHC and WB • TIP60 belongs to the MYST family of HATs. It is a catalytic subunit of the NuA4 HAT complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A.  

     

    Brand:
    Cayman
    SKU:13789- 1 ea
  • Tipifarnib is a nonpeptidomimetic, CAAX-competitive inhibitor of farnesyltransferase (IC50 = 0.86 nM).{33516} It prevents farnesylation of Ras GTPases and has shown potent efficacy in various in vitro and in vivo tumor models.{21247,21707}  

     

    Brand:
    Cayman
    SKU:11747 - 1 mg

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  • Tipifarnib is a nonpeptidomimetic, CAAX-competitive inhibitor of farnesyltransferase (IC50 = 0.86 nM).{33516} It prevents farnesylation of Ras GTPases and has shown potent efficacy in various in vitro and in vivo tumor models.{21247,21707}  

     

    Brand:
    Cayman
    SKU:11747 - 10 mg

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  • Tipifarnib is a nonpeptidomimetic, CAAX-competitive inhibitor of farnesyltransferase (IC50 = 0.86 nM).{33516} It prevents farnesylation of Ras GTPases and has shown potent efficacy in various in vitro and in vivo tumor models.{21247,21707}  

     

    Brand:
    Cayman
    SKU:11747 - 5 mg

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  • Tipiracil (TPI) is a potent and competitive inhibitor of thymidine phosphorylase (TPase) with an IC50 value of 35 nM for human placental TPase.{40279} It is selective for TPase over other pyrimidine-metabolizing enzymes (IC50s = >1 mM for UPase, OPRTase, TK, and DPDase). TPI inhibits the phosphorolysis and degradation of trifluorothymidine (Item No. 21366), a cytotoxic nucleoside, in human breast and colon carcinoma tumor samples. Oral administration of TPI (12.5-50 mg/kg) enhances the anti-tumor activity of trifluorothymidine in a mouse AZ-521 stomach cancer xenograft model. Formulations containing TPI have been used for the treatment of metastatic colorectal cancer.{40281}  

     

    Brand:
    Cayman
    SKU:23319 - 1 mg

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  • Tipiracil (TPI) is a potent and competitive inhibitor of thymidine phosphorylase (TPase) with an IC50 value of 35 nM for human placental TPase.{40279} It is selective for TPase over other pyrimidine-metabolizing enzymes (IC50s = >1 mM for UPase, OPRTase, TK, and DPDase). TPI inhibits the phosphorolysis and degradation of trifluorothymidine (Item No. 21366), a cytotoxic nucleoside, in human breast and colon carcinoma tumor samples. Oral administration of TPI (12.5-50 mg/kg) enhances the anti-tumor activity of trifluorothymidine in a mouse AZ-521 stomach cancer xenograft model. Formulations containing TPI have been used for the treatment of metastatic colorectal cancer.{40281}  

     

    Brand:
    Cayman
    SKU:23319 - 10 mg

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  • Tipiracil (TPI) is a potent and competitive inhibitor of thymidine phosphorylase (TPase) with an IC50 value of 35 nM for human placental TPase.{40279} It is selective for TPase over other pyrimidine-metabolizing enzymes (IC50s = >1 mM for UPase, OPRTase, TK, and DPDase). TPI inhibits the phosphorolysis and degradation of trifluorothymidine (Item No. 21366), a cytotoxic nucleoside, in human breast and colon carcinoma tumor samples. Oral administration of TPI (12.5-50 mg/kg) enhances the anti-tumor activity of trifluorothymidine in a mouse AZ-521 stomach cancer xenograft model. Formulations containing TPI have been used for the treatment of metastatic colorectal cancer.{40281}  

     

    Brand:
    Cayman
    SKU:23319 - 25 mg

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  • Tipiracil (TPI) is a potent and competitive inhibitor of thymidine phosphorylase (TPase) with an IC50 value of 35 nM for human placental TPase.{40279} It is selective for TPase over other pyrimidine-metabolizing enzymes (IC50s = >1 mM for UPase, OPRTase, TK, and DPDase). TPI inhibits the phosphorolysis and degradation of trifluorothymidine (Item No. 21366), a cytotoxic nucleoside, in human breast and colon carcinoma tumor samples. Oral administration of TPI (12.5-50 mg/kg) enhances the anti-tumor activity of trifluorothymidine in a mouse AZ-521 stomach cancer xenograft model. Formulations containing TPI have been used for the treatment of metastatic colorectal cancer.{40281}  

     

    Brand:
    Cayman
    SKU:23319 - 5 mg

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  • Tiplaxtinin is an inhibitor of plasminogen activator inhibitor 1 (PAI-1; IC50 = 2.7 µM with human recombinant PAI-1).{34136} In rat thrombosis models, the time to occlusion is longer, carotid blood flow reduction is partially prevented, and thrombus size is smaller compared with control rats.{34136,34137}  

     

    Brand:
    Cayman
    SKU:9000450 - 1 mg

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  • Tiplaxtinin is an inhibitor of plasminogen activator inhibitor 1 (PAI-1; IC50 = 2.7 µM with human recombinant PAI-1).{34136} In rat thrombosis models, the time to occlusion is longer, carotid blood flow reduction is partially prevented, and thrombus size is smaller compared with control rats.{34136,34137}  

     

    Brand:
    Cayman
    SKU:9000450 - 10 mg

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  • Tiplaxtinin is an inhibitor of plasminogen activator inhibitor 1 (PAI-1; IC50 = 2.7 µM with human recombinant PAI-1).{34136} In rat thrombosis models, the time to occlusion is longer, carotid blood flow reduction is partially prevented, and thrombus size is smaller compared with control rats.{34136,34137}  

     

    Brand:
    Cayman
    SKU:9000450 - 5 mg

    Available on backorder

  • Tiplaxtinin is an inhibitor of plasminogen activator inhibitor 1 (PAI-1; IC50 = 2.7 µM with human recombinant PAI-1).{34136} In rat thrombosis models, the time to occlusion is longer, carotid blood flow reduction is partially prevented, and thrombus size is smaller compared with control rats.{34136,34137}  

     

    Brand:
    Cayman
    SKU:9000450 - 50 mg

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  • Tipranavir is a potent, orally bioavailable nonpeptidic HIV aspartyl protease inhibitor (Ki = < 1 nM) that prevents cleavage and thus activation of functional HIV cleaved proteins.{34181,34180} Formulations containing tipranavir, in combination with other HIV treatments, are effective against multidrug resistant viruses and are used in the treatment of HIV infection progression in patients who have not responded well to initial treatments.{34179}  

     

    Brand:
    Cayman
    SKU:21028 -

    Out of stock

  • Tipranavir is a potent, orally bioavailable nonpeptidic HIV aspartyl protease inhibitor (Ki = < 1 nM) that prevents cleavage and thus activation of functional HIV cleaved proteins.{34181,34180} Formulations containing tipranavir, in combination with other HIV treatments, are effective against multidrug resistant viruses and are used in the treatment of HIV infection progression in patients who have not responded well to initial treatments.{34179}  

     

    Brand:
    Cayman
    SKU:21028 -

    Out of stock

  • Tipranavir-d4 is intended for use as an internal standard for the quantification of tipranavir (Item No. 21028) by GC- or LC-MS. Tipranavir is a potent, orally bioavailable nonpeptidic HIV aspartyl protease inhibitor (Ki = <1 nM) that prevents cleavage and thus activation of functional HIV-cleaved proteins.{34180,34181} Formulations containing tipranavir, in combination with other HIV treatments, are effective against multidrug resistant viruses and are used in the treatment of HIV infection progression in patients who have not responded well to initial treatments.  

     

    Brand:
    Cayman
    SKU:28907 - 1 mg

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  • Poly(ADP-ribose) polymerase 1 (PARP1) is a critical DNA repair enzyme involved in DNA single-strand break repair via the base excision repair pathway. PARP1 is triggered by DNA damage and its excessive activation has been proposed as a causative factor in many pathological conditions including ischemia and reperfusion injury, asthma-related inflammation, and atherogenesis.{27086,27088,27087} TIQ-A is a PARP1 inhibitor (IC50 = 450 nM in cultured mouse cortical neurons).{27086} It displays neuroprotective effects in cultured mouse cortical neurons injured by oxygen-glucose deprivation (IC50 = 0.15 µM). TIQ-A has been used to inhibit eosinophilic infiltration into airways of OVA-challenged mice and to induce the regression of atherosclerotic plaques in high-fat fed apolipoprotein E(-/-) mice.{27088,27087}  

     

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    Cayman
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  • Poly(ADP-ribose) polymerase 1 (PARP1) is a critical DNA repair enzyme involved in DNA single-strand break repair via the base excision repair pathway. PARP1 is triggered by DNA damage and its excessive activation has been proposed as a causative factor in many pathological conditions including ischemia and reperfusion injury, asthma-related inflammation, and atherogenesis.{27086,27088,27087} TIQ-A is a PARP1 inhibitor (IC50 = 450 nM in cultured mouse cortical neurons).{27086} It displays neuroprotective effects in cultured mouse cortical neurons injured by oxygen-glucose deprivation (IC50 = 0.15 µM). TIQ-A has been used to inhibit eosinophilic infiltration into airways of OVA-challenged mice and to induce the regression of atherosclerotic plaques in high-fat fed apolipoprotein E(-/-) mice.{27088,27087}  

     

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    Cayman
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  • Poly(ADP-ribose) polymerase 1 (PARP1) is a critical DNA repair enzyme involved in DNA single-strand break repair via the base excision repair pathway. PARP1 is triggered by DNA damage and its excessive activation has been proposed as a causative factor in many pathological conditions including ischemia and reperfusion injury, asthma-related inflammation, and atherogenesis.{27086,27088,27087} TIQ-A is a PARP1 inhibitor (IC50 = 450 nM in cultured mouse cortical neurons).{27086} It displays neuroprotective effects in cultured mouse cortical neurons injured by oxygen-glucose deprivation (IC50 = 0.15 µM). TIQ-A has been used to inhibit eosinophilic infiltration into airways of OVA-challenged mice and to induce the regression of atherosclerotic plaques in high-fat fed apolipoprotein E(-/-) mice.{27088,27087}  

     

    Brand:
    Cayman
    SKU:-
  • Poly(ADP-ribose) polymerase 1 (PARP1) is a critical DNA repair enzyme involved in DNA single-strand break repair via the base excision repair pathway. PARP1 is triggered by DNA damage and its excessive activation has been proposed as a causative factor in many pathological conditions including ischemia and reperfusion injury, asthma-related inflammation, and atherogenesis.{27086,27088,27087} TIQ-A is a PARP1 inhibitor (IC50 = 450 nM in cultured mouse cortical neurons).{27086} It displays neuroprotective effects in cultured mouse cortical neurons injured by oxygen-glucose deprivation (IC50 = 0.15 µM). TIQ-A has been used to inhibit eosinophilic infiltration into airways of OVA-challenged mice and to induce the regression of atherosclerotic plaques in high-fat fed apolipoprotein E(-/-) mice.{27088,27087}  

     

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    Cayman
    SKU:-
  • Tirapazamine is a hypoxia-activated anticancer agent.{46027} It is converted to an oxidizing radical under hypoxic conditions and can induce single- and double-strand breaks in DNA, formation of trapped topoisomerase I- and II-DNA complexes, and other chromosomal aberrations, leading to cytotoxicity.{46027,46028,46029} Tirapazamine induces hypoxia-enhanced cytotoxicity in DT40 cells (IC50s = 1.02 and 4.34 μM in hypoxic and normoxic conditions, respectively).{46029} It also induces cytotoxicity in HT-1080 and A549 cells in a concentration-dependent manner under hypoxic conditions.{46027} In vivo, tirapazamine sensitizes tumors to cisplatin (Item No. 13119) in a mouse RIF-1 fibrosarcoma tumor model.{46030} Tirapazamine (0.08 mmol/kg) also sensitizes tumors to fractionated irradiation in a FaDu hypopharyngeal squamous cell carcinoma mouse xenograft model.{46031}  

     

    Brand:
    Cayman
    SKU:25981 - 10 mg

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  • Tirapazamine is a hypoxia-activated anticancer agent.{46027} It is converted to an oxidizing radical under hypoxic conditions and can induce single- and double-strand breaks in DNA, formation of trapped topoisomerase I- and II-DNA complexes, and other chromosomal aberrations, leading to cytotoxicity.{46027,46028,46029} Tirapazamine induces hypoxia-enhanced cytotoxicity in DT40 cells (IC50s = 1.02 and 4.34 μM in hypoxic and normoxic conditions, respectively).{46029} It also induces cytotoxicity in HT-1080 and A549 cells in a concentration-dependent manner under hypoxic conditions.{46027} In vivo, tirapazamine sensitizes tumors to cisplatin (Item No. 13119) in a mouse RIF-1 fibrosarcoma tumor model.{46030} Tirapazamine (0.08 mmol/kg) also sensitizes tumors to fractionated irradiation in a FaDu hypopharyngeal squamous cell carcinoma mouse xenograft model.{46031}  

     

    Brand:
    Cayman
    SKU:25981 - 100 mg

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  • Tirapazamine is a hypoxia-activated anticancer agent.{46027} It is converted to an oxidizing radical under hypoxic conditions and can induce single- and double-strand breaks in DNA, formation of trapped topoisomerase I- and II-DNA complexes, and other chromosomal aberrations, leading to cytotoxicity.{46027,46028,46029} Tirapazamine induces hypoxia-enhanced cytotoxicity in DT40 cells (IC50s = 1.02 and 4.34 μM in hypoxic and normoxic conditions, respectively).{46029} It also induces cytotoxicity in HT-1080 and A549 cells in a concentration-dependent manner under hypoxic conditions.{46027} In vivo, tirapazamine sensitizes tumors to cisplatin (Item No. 13119) in a mouse RIF-1 fibrosarcoma tumor model.{46030} Tirapazamine (0.08 mmol/kg) also sensitizes tumors to fractionated irradiation in a FaDu hypopharyngeal squamous cell carcinoma mouse xenograft model.{46031}  

     

    Brand:
    Cayman
    SKU:25981 - 250 mg

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  • Tirapazamine is a hypoxia-activated anticancer agent.{46027} It is converted to an oxidizing radical under hypoxic conditions and can induce single- and double-strand breaks in DNA, formation of trapped topoisomerase I- and II-DNA complexes, and other chromosomal aberrations, leading to cytotoxicity.{46027,46028,46029} Tirapazamine induces hypoxia-enhanced cytotoxicity in DT40 cells (IC50s = 1.02 and 4.34 μM in hypoxic and normoxic conditions, respectively).{46029} It also induces cytotoxicity in HT-1080 and A549 cells in a concentration-dependent manner under hypoxic conditions.{46027} In vivo, tirapazamine sensitizes tumors to cisplatin (Item No. 13119) in a mouse RIF-1 fibrosarcoma tumor model.{46030} Tirapazamine (0.08 mmol/kg) also sensitizes tumors to fractionated irradiation in a FaDu hypopharyngeal squamous cell carcinoma mouse xenograft model.{46031}  

     

    Brand:
    Cayman
    SKU:25981 - 50 mg

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  • Tirasemtiv is an activator of the fast skeletal troponin complex.{36966} It selectively binds to purified fast skeletal troponin complex (Kd = 40 nM) over slow skeletal (Kd = 3,800 nM) and cardiac troponin complexes. Tirasemtiv (20 μM) slows the rate of calcium release from the fast skeletal troponin complex. It increases the ATPase activity of isolated rabbit fast skeletal myofibrils at a fixed calcium concentration (EC50 = 390 nM) and sensitizes skinned fast skeletal muscle fibers isolated from human and rabbit to calcium in a concentration-dependent manner. Tirasemtiv increases in situ extensor digitorum longus (EDL) muscle force and forelimb grip strength in a rat model of myasthenia gravis. It also increases forelimb grip strength, grid hang test performance, and rotarod performance in a mouse model of amyotrophic lateral sclerosis (ALS) when administered at a dose of 10 mg/kg.{36967}  

     

    Brand:
    Cayman
    SKU:26075 - 10 mg

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  • Tirasemtiv is an activator of the fast skeletal troponin complex.{36966} It selectively binds to purified fast skeletal troponin complex (Kd = 40 nM) over slow skeletal (Kd = 3,800 nM) and cardiac troponin complexes. Tirasemtiv (20 μM) slows the rate of calcium release from the fast skeletal troponin complex. It increases the ATPase activity of isolated rabbit fast skeletal myofibrils at a fixed calcium concentration (EC50 = 390 nM) and sensitizes skinned fast skeletal muscle fibers isolated from human and rabbit to calcium in a concentration-dependent manner. Tirasemtiv increases in situ extensor digitorum longus (EDL) muscle force and forelimb grip strength in a rat model of myasthenia gravis. It also increases forelimb grip strength, grid hang test performance, and rotarod performance in a mouse model of amyotrophic lateral sclerosis (ALS) when administered at a dose of 10 mg/kg.{36967}  

     

    Brand:
    Cayman
    SKU:26075 - 25 mg

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  • Tirasemtiv is an activator of the fast skeletal troponin complex.{36966} It selectively binds to purified fast skeletal troponin complex (Kd = 40 nM) over slow skeletal (Kd = 3,800 nM) and cardiac troponin complexes. Tirasemtiv (20 μM) slows the rate of calcium release from the fast skeletal troponin complex. It increases the ATPase activity of isolated rabbit fast skeletal myofibrils at a fixed calcium concentration (EC50 = 390 nM) and sensitizes skinned fast skeletal muscle fibers isolated from human and rabbit to calcium in a concentration-dependent manner. Tirasemtiv increases in situ extensor digitorum longus (EDL) muscle force and forelimb grip strength in a rat model of myasthenia gravis. It also increases forelimb grip strength, grid hang test performance, and rotarod performance in a mouse model of amyotrophic lateral sclerosis (ALS) when administered at a dose of 10 mg/kg.{36967}  

     

    Brand:
    Cayman
    SKU:26075 - 5 mg

    Available on backorder

  • Tirasemtiv is an activator of the fast skeletal troponin complex.{36966} It selectively binds to purified fast skeletal troponin complex (Kd = 40 nM) over slow skeletal (Kd = 3,800 nM) and cardiac troponin complexes. Tirasemtiv (20 μM) slows the rate of calcium release from the fast skeletal troponin complex. It increases the ATPase activity of isolated rabbit fast skeletal myofibrils at a fixed calcium concentration (EC50 = 390 nM) and sensitizes skinned fast skeletal muscle fibers isolated from human and rabbit to calcium in a concentration-dependent manner. Tirasemtiv increases in situ extensor digitorum longus (EDL) muscle force and forelimb grip strength in a rat model of myasthenia gravis. It also increases forelimb grip strength, grid hang test performance, and rotarod performance in a mouse model of amyotrophic lateral sclerosis (ALS) when administered at a dose of 10 mg/kg.{36967}  

     

    Brand:
    Cayman
    SKU:26075 - 50 mg

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  • Tiratricol is a metabolite of 3,3′,5-triiodo-L-thyronine (Item No. 16028) and an agonist of the thyroid hormone receptors TRα and TRβ (EC50s = 1.81 and 4.13 nM, respectively, in reporter assays).{45575} In vivo, tiratricol (50 or 400 ng/g) stimulates cerebellar Purkinje cell dendritogenesis and cortical myelination in Mct8/Oatp1c1 double knockout mice.{45574} It reduces goiter induced by methimazole (Item No. 23718) in rats when administered at a dose of 25 μg per animal.{45572} Tiratricol also decreases toll-like receptor 2 (TLR2) levels and the phosphorylation of Akt and MAPK in HEK-Blue™ cells expressing human TLR2 and reduces liver tissue necrosis in a mouse model of hepatitis induced by concanavalin A (Item No. 14951).{45573}.  

     

    Brand:
    Cayman
    SKU:28729 - 1 g

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  • Tiratricol is a metabolite of 3,3′,5-triiodo-L-thyronine (Item No. 16028) and an agonist of the thyroid hormone receptors TRα and TRβ (EC50s = 1.81 and 4.13 nM, respectively, in reporter assays).{45575} In vivo, tiratricol (50 or 400 ng/g) stimulates cerebellar Purkinje cell dendritogenesis and cortical myelination in Mct8/Oatp1c1 double knockout mice.{45574} It reduces goiter induced by methimazole (Item No. 23718) in rats when administered at a dose of 25 μg per animal.{45572} Tiratricol also decreases toll-like receptor 2 (TLR2) levels and the phosphorylation of Akt and MAPK in HEK-Blue™ cells expressing human TLR2 and reduces liver tissue necrosis in a mouse model of hepatitis induced by concanavalin A (Item No. 14951).{45573}.  

     

    Brand:
    Cayman
    SKU:28729 - 100 mg

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  • Tiratricol is a metabolite of 3,3′,5-triiodo-L-thyronine (Item No. 16028) and an agonist of the thyroid hormone receptors TRα and TRβ (EC50s = 1.81 and 4.13 nM, respectively, in reporter assays).{45575} In vivo, tiratricol (50 or 400 ng/g) stimulates cerebellar Purkinje cell dendritogenesis and cortical myelination in Mct8/Oatp1c1 double knockout mice.{45574} It reduces goiter induced by methimazole (Item No. 23718) in rats when administered at a dose of 25 μg per animal.{45572} Tiratricol also decreases toll-like receptor 2 (TLR2) levels and the phosphorylation of Akt and MAPK in HEK-Blue™ cells expressing human TLR2 and reduces liver tissue necrosis in a mouse model of hepatitis induced by concanavalin A (Item No. 14951).{45573}.  

     

    Brand:
    Cayman
    SKU:28729 - 50 mg

    Available on backorder

  • Tiratricol is a metabolite of 3,3′,5-triiodo-L-thyronine (Item No. 16028) and an agonist of the thyroid hormone receptors TRα and TRβ (EC50s = 1.81 and 4.13 nM, respectively, in reporter assays).{45575} In vivo, tiratricol (50 or 400 ng/g) stimulates cerebellar Purkinje cell dendritogenesis and cortical myelination in Mct8/Oatp1c1 double knockout mice.{45574} It reduces goiter induced by methimazole (Item No. 23718) in rats when administered at a dose of 25 μg per animal.{45572} Tiratricol also decreases toll-like receptor 2 (TLR2) levels and the phosphorylation of Akt and MAPK in HEK-Blue™ cells expressing human TLR2 and reduces liver tissue necrosis in a mouse model of hepatitis induced by concanavalin A (Item No. 14951).{45573}.  

     

    Brand:
    Cayman
    SKU:28729 - 500 mg

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  • Tirofiban is a potent nonpeptide glycoprotein IIb/IIIa antagonist (GPIIb/IIIa; IC50 = 5 nM in a radioligand binding assay).{37214} It inhibits GPIIb/IIIa-dependent platelet aggregation with an IC50 value of 11 nM. Tirofiban is selective for platelet GPIIb/IIIa, only inhibiting human umbilical vein endothelial cell (HUVEC) attachment to microtiter plates containing fibrinogen (Fg), human vitronectin (Vn), or human fibronectin (Fn) at concentrations >10,000-fold above the IC50 for platelet aggregation. Tirofiban (300 and 1,000 μg/kg per minute, i.v.) prevents occlusive thrombosis and reduces thrombus mass in a canine model of electrically-induced coronary artery occlusive thrombosis.{37215} Formulations containing tirofiban have been used to prevent thrombotic occlusion associated with coronary angioplasty.{37216}  

     

    Brand:
    Cayman
    SKU:23392 - 1 mg

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  • Tirofiban is a potent nonpeptide glycoprotein IIb/IIIa antagonist (GPIIb/IIIa; IC50 = 5 nM in a radioligand binding assay).{37214} It inhibits GPIIb/IIIa-dependent platelet aggregation with an IC50 value of 11 nM. Tirofiban is selective for platelet GPIIb/IIIa, only inhibiting human umbilical vein endothelial cell (HUVEC) attachment to microtiter plates containing fibrinogen (Fg), human vitronectin (Vn), or human fibronectin (Fn) at concentrations >10,000-fold above the IC50 for platelet aggregation. Tirofiban (300 and 1,000 μg/kg per minute, i.v.) prevents occlusive thrombosis and reduces thrombus mass in a canine model of electrically-induced coronary artery occlusive thrombosis.{37215} Formulations containing tirofiban have been used to prevent thrombotic occlusion associated with coronary angioplasty.{37216}  

     

    Brand:
    Cayman
    SKU:23392 - 10 mg

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  • Tirofiban is a potent nonpeptide glycoprotein IIb/IIIa antagonist (GPIIb/IIIa; IC50 = 5 nM in a radioligand binding assay).{37214} It inhibits GPIIb/IIIa-dependent platelet aggregation with an IC50 value of 11 nM. Tirofiban is selective for platelet GPIIb/IIIa, only inhibiting human umbilical vein endothelial cell (HUVEC) attachment to microtiter plates containing fibrinogen (Fg), human vitronectin (Vn), or human fibronectin (Fn) at concentrations >10,000-fold above the IC50 for platelet aggregation. Tirofiban (300 and 1,000 μg/kg per minute, i.v.) prevents occlusive thrombosis and reduces thrombus mass in a canine model of electrically-induced coronary artery occlusive thrombosis.{37215} Formulations containing tirofiban have been used to prevent thrombotic occlusion associated with coronary angioplasty.{37216}  

     

    Brand:
    Cayman
    SKU:23392 - 5 mg

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  • MET is a proto-oncogene that encodes the hepatocyte growth factor receptor c-Met. The receptor has normal roles in morphogenesis, migration, apoptosis, and angiogenesis.{23657} Dysregulation of c-Met occurs in many types of cancer.{23657} Tivantinib is a staurosporine (Item No. 81590) derivative that binds to dephosphorylated c-Met kinase, yet its mechanism of action is not known.{27930} Tivantinib has been tested in clinical studies for its ability to selectively inhibit c-Met.{27930} However, it can promote mitotic arrest and apoptosis of various human tumor cell lines (EC50s ranging from 60-600 nM) through mechanisms independent of its ability to bind c-Met.{27930} Tivantinib has been reported to bind directly to the colchicine binding site of tubulin, reducing tubulin polymerization in cells and in mouse xenograft tumors in vivo.{27931}  

     

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  • MET is a proto-oncogene that encodes the hepatocyte growth factor receptor c-Met. The receptor has normal roles in morphogenesis, migration, apoptosis, and angiogenesis.{23657} Dysregulation of c-Met occurs in many types of cancer.{23657} Tivantinib is a staurosporine (Item No. 81590) derivative that binds to dephosphorylated c-Met kinase, yet its mechanism of action is not known.{27930} Tivantinib has been tested in clinical studies for its ability to selectively inhibit c-Met.{27930} However, it can promote mitotic arrest and apoptosis of various human tumor cell lines (EC50s ranging from 60-600 nM) through mechanisms independent of its ability to bind c-Met.{27930} Tivantinib has been reported to bind directly to the colchicine binding site of tubulin, reducing tubulin polymerization in cells and in mouse xenograft tumors in vivo.{27931}  

     

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    Cayman
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    Out of stock

  • MET is a proto-oncogene that encodes the hepatocyte growth factor receptor c-Met. The receptor has normal roles in morphogenesis, migration, apoptosis, and angiogenesis.{23657} Dysregulation of c-Met occurs in many types of cancer.{23657} Tivantinib is a staurosporine (Item No. 81590) derivative that binds to dephosphorylated c-Met kinase, yet its mechanism of action is not known.{27930} Tivantinib has been tested in clinical studies for its ability to selectively inhibit c-Met.{27930} However, it can promote mitotic arrest and apoptosis of various human tumor cell lines (EC50s ranging from 60-600 nM) through mechanisms independent of its ability to bind c-Met.{27930} Tivantinib has been reported to bind directly to the colchicine binding site of tubulin, reducing tubulin polymerization in cells and in mouse xenograft tumors in vivo.{27931}  

     

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    Cayman
    SKU:-

    Out of stock

  • Tivozanib is an orally available, selective VEGFR inhibitor with IC50 values of 0.21, 0.16, and 0.24 nM for VEGFR1, VEGFR2, and VEGFR3, respectively.{19939,32739} It can also inhibit c-Kit and PDGFRβ with IC50 values of 1.63 and 1.72 nM, respectively.{32739} When administered to athymic rats, tivozanib was shown to decrease the microvessel density within tumor xenografts and attenuate VEGFR2 phosphorylation levels in tumor endothelium.{32739} It also displays antitumor activity against a wide variety of human tumor xenografts, including lung, breast, colon, ovarian, pancreas, and prostate cancer.{32739}  

     

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  • Tivozanib is an orally available, selective VEGFR inhibitor with IC50 values of 0.21, 0.16, and 0.24 nM for VEGFR1, VEGFR2, and VEGFR3, respectively.{19939,32739} It can also inhibit c-Kit and PDGFRβ with IC50 values of 1.63 and 1.72 nM, respectively.{32739} When administered to athymic rats, tivozanib was shown to decrease the microvessel density within tumor xenografts and attenuate VEGFR2 phosphorylation levels in tumor endothelium.{32739} It also displays antitumor activity against a wide variety of human tumor xenografts, including lung, breast, colon, ovarian, pancreas, and prostate cancer.{32739}  

     

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    SKU:-

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  • Tivozanib is an orally available, selective VEGFR inhibitor with IC50 values of 0.21, 0.16, and 0.24 nM for VEGFR1, VEGFR2, and VEGFR3, respectively.{19939,32739} It can also inhibit c-Kit and PDGFRβ with IC50 values of 1.63 and 1.72 nM, respectively.{32739} When administered to athymic rats, tivozanib was shown to decrease the microvessel density within tumor xenografts and attenuate VEGFR2 phosphorylation levels in tumor endothelium.{32739} It also displays antitumor activity against a wide variety of human tumor xenografts, including lung, breast, colon, ovarian, pancreas, and prostate cancer.{32739}  

     

    Brand:
    Cayman
    SKU:-

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  • Tizanidine is an α2-adrenergic receptor (α2-AR) agonist.{39278} Administration of tizanidine reduces neuronal excitation induced by noxious stimuli and depresses spontaneous neuronal firing in anesthetized cats. Tizanidine-induced neuronal depression is reversed by the selective α2-AR antagonist RX781094 but not the α1-AR antagonists prazosin (Item No. 15023) and WB-4101. It acts as a muscle relaxant that inhibits α- and γ-rigidity in rats, reflex muscle tone in rabbits, and the linguomadibular reflex in cats without sedative, hemodynamic, or neurochemical effects.{39279} Formulations containing tizanidine have been used for the treatment of stiff-person syndrome and to improve gait function in patients with incomplete spinal cord injuries.{39280,39281}  

     

    Brand:
    Cayman
    SKU:-

    Out of stock

  • Tizanidine is an α2-adrenergic receptor (α2-AR) agonist.{39278} Administration of tizanidine reduces neuronal excitation induced by noxious stimuli and depresses spontaneous neuronal firing in anesthetized cats. Tizanidine-induced neuronal depression is reversed by the selective α2-AR antagonist RX781094 but not the α1-AR antagonists prazosin (Item No. 15023) and WB-4101. It acts as a muscle relaxant that inhibits α- and γ-rigidity in rats, reflex muscle tone in rabbits, and the linguomadibular reflex in cats without sedative, hemodynamic, or neurochemical effects.{39279} Formulations containing tizanidine have been used for the treatment of stiff-person syndrome and to improve gait function in patients with incomplete spinal cord injuries.{39280,39281}  

     

    Brand:
    Cayman
    SKU:-

    Out of stock

  • Tizanidine is an α2-adrenergic receptor (α2-AR) agonist.{39278} Administration of tizanidine reduces neuronal excitation induced by noxious stimuli and depresses spontaneous neuronal firing in anesthetized cats. Tizanidine-induced neuronal depression is reversed by the selective α2-AR antagonist RX781094 but not the α1-AR antagonists prazosin (Item No. 15023) and WB-4101. It acts as a muscle relaxant that inhibits α- and γ-rigidity in rats, reflex muscle tone in rabbits, and the linguomadibular reflex in cats without sedative, hemodynamic, or neurochemical effects.{39279} Formulations containing tizanidine have been used for the treatment of stiff-person syndrome and to improve gait function in patients with incomplete spinal cord injuries.{39280,39281}  

     

    Brand:
    Cayman
    SKU:-

    Out of stock

  • Tizanidine is an α2-adrenergic receptor (α2-AR) agonist.{39278} Administration of tizanidine reduces neuronal excitation induced by noxious stimuli and depresses spontaneous neuronal firing in anesthetized cats. Tizanidine-induced neuronal depression is reversed by the selective α2-AR antagonist RX781094 but not the α1-AR antagonists prazosin (Item No. 15023) and WB-4101. It acts as a muscle relaxant that inhibits α- and γ-rigidity in rats, reflex muscle tone in rabbits, and the linguomadibular reflex in cats without sedative, hemodynamic, or neurochemical effects.{39279} Formulations containing tizanidine have been used for the treatment of stiff-person syndrome and to improve gait function in patients with incomplete spinal cord injuries.{39280,39281}  

     

    Brand:
    Cayman
    SKU:-

    Out of stock

  • Tizanidine-d4 is intended for use as an internal standard for the quantification of tizanidine (Item No. 16477) by GC- or LC-MS. Tizanidine is an α2-adrenergic receptor (α2-AR) agonist.{39278} Administration of tizanidine reduces neuronal excitation induced by noxious stimuli and depresses spontaneous neuronal firing in anesthetized cats. Tizanidine-induced neuronal depression is reversed by the selective α2-AR antagonist RX781094 but not the α1-AR antagonists prazosin (Item No. 15023) and WB-4101. It acts as a muscle relaxant that inhibits α- and γ-rigidity in rats, reflex muscle tone in rabbits, and the linguomadibular reflex in cats without sedative, hemodynamic, or neurochemical effects.{39279} Formulations containing tizanidine have been used for the treatment of stiff-person syndrome and to improve gait function in patients with incomplete spinal cord injuries.{39280,39281}  

     

    Brand:
    Cayman
    SKU:26521 - 1 mg

    Available on backorder

  • Tizanidine-d4 is intended for use as an internal standard for the quantification of tizanidine (Item No. 16477) by GC- or LC-MS. Tizanidine is an α2-adrenergic receptor (α2-AR) agonist.{39278} Administration of tizanidine reduces neuronal excitation induced by noxious stimuli and depresses spontaneous neuronal firing in anesthetized cats. Tizanidine-induced neuronal depression is reversed by the selective α2-AR antagonist RX781094 but not the α1-AR antagonists prazosin (Item No. 15023) and WB-4101. It acts as a muscle relaxant that inhibits α- and γ-rigidity in rats, reflex muscle tone in rabbits, and the linguomadibular reflex in cats without sedative, hemodynamic, or neurochemical effects.{39279} Formulations containing tizanidine have been used for the treatment of stiff-person syndrome and to improve gait function in patients with incomplete spinal cord injuries.{39280,39281}  

     

    Brand:
    Cayman
    SKU:26521 - 500 µg

    Available on backorder

  • Tizoxanide is an active metabolite of the antiparasitic nitazoxanide (Item No. 13692).{17926} Tizoxanide is formed from nitazoxanide via deacetylation of nitazoxanide in the stomach. It is active against M. tuberculosis (MIC = 16 µg/ml). It also reduces the growth of the disease-causing parasites L. mexicana and T. cruzi in vitro (IC50s = 6.2 and 17.5 μM, respectively), inhibits influenza A replication (EC50s = 0.3-1 μM), and inhibits hepatitis B and hepatitis C virus replication (EC50 = 0.15 μM for both).{19983,19984,19985}  

     

    Brand:
    Cayman
    SKU:-
  • Tizoxanide is an active metabolite of the antiparasitic nitazoxanide (Item No. 13692).{17926} Tizoxanide is formed from nitazoxanide via deacetylation of nitazoxanide in the stomach. It is active against M. tuberculosis (MIC = 16 µg/ml). It also reduces the growth of the disease-causing parasites L. mexicana and T. cruzi in vitro (IC50s = 6.2 and 17.5 μM, respectively), inhibits influenza A replication (EC50s = 0.3-1 μM), and inhibits hepatitis B and hepatitis C virus replication (EC50 = 0.15 μM for both).{19983,19984,19985}  

     

    Brand:
    Cayman
    SKU:-
  • Tizoxanide is an active metabolite of the antiparasitic nitazoxanide (Item No. 13692).{17926} Tizoxanide is formed from nitazoxanide via deacetylation of nitazoxanide in the stomach. It is active against M. tuberculosis (MIC = 16 µg/ml). It also reduces the growth of the disease-causing parasites L. mexicana and T. cruzi in vitro (IC50s = 6.2 and 17.5 μM, respectively), inhibits influenza A replication (EC50s = 0.3-1 μM), and inhibits hepatitis B and hepatitis C virus replication (EC50 = 0.15 μM for both).{19983,19984,19985}  

     

    Brand:
    Cayman
    SKU:-
  • Tizoxanide is an active metabolite of the antiparasitic nitazoxanide (Item No. 13692).{17926} Tizoxanide is formed from nitazoxanide via deacetylation of nitazoxanide in the stomach. It is active against M. tuberculosis (MIC = 16 µg/ml). It also reduces the growth of the disease-causing parasites L. mexicana and T. cruzi in vitro (IC50s = 6.2 and 17.5 μM, respectively), inhibits influenza A replication (EC50s = 0.3-1 μM), and inhibits hepatitis B and hepatitis C virus replication (EC50 = 0.15 μM for both).{19983,19984,19985}  

     

    Brand:
    Cayman
    SKU:-
  • Tizoxanide-d4 is intended for use as an internal standard for the quantification of tizoxanide (Item No. 13693) by GC- or LC-MS. Tizoxanide is an active metabolite of the antiparasitic nitazoxanide (Item No. 13692).{17926} Tizoxanide is formed from nitazoxanide via deacetylation of nitazoxanide in the stomach. It is active against M. tuberculosis (MIC = 16 µg/ml). It also reduces the growth of the disease-causing parasites L. mexicana and T. cruzi in vitro (IC50s = 6.2 and 17.5 μM, respectively), inhibits influenza A replication (EC50s = 0.3-1 μM), and inhibits hepatitis B and hepatitis C virus replication (EC50 = 0.15 μM for both).{19984,19985,19983}  

     

    Brand:
    Cayman
    SKU:28533 - 1 mg

    Available on backorder

  • Toll-like receptor 4 (TLR4) is activated by lipopolysaccharide (LPS), with LPS-binding protein, to initiate an innate immune response, which typically includes increased expression of TNFα.{28195} TLR4-C34 is a 2-acetamidopyranoside that inhibits TLR4 signaling in enterocytes and macrophages in vitro when used at 10 µM.{29731,29732} It does not affect signaling through either TLR2 or TLR9. TLR4-C34, used at 1 mg/kg in vivo, also reduces systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis.{29731} It markedly decreases the basal expression of TNFα, as well as LPS-induced iNOS and TNFα expression, in intestinal tissue isolated from patients with necrotizing enterocolitis.{29731}  

     

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    Cayman
    SKU:-

    Available on backorder

  • Toll-like receptor 4 (TLR4) is activated by lipopolysaccharide (LPS), with LPS-binding protein, to initiate an innate immune response, which typically includes increased expression of TNFα.{28195} TLR4-C34 is a 2-acetamidopyranoside that inhibits TLR4 signaling in enterocytes and macrophages in vitro when used at 10 µM.{29731,29732} It does not affect signaling through either TLR2 or TLR9. TLR4-C34, used at 1 mg/kg in vivo, also reduces systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis.{29731} It markedly decreases the basal expression of TNFα, as well as LPS-induced iNOS and TNFα expression, in intestinal tissue isolated from patients with necrotizing enterocolitis.{29731}  

     

    Brand:
    Cayman
    SKU:-

    Available on backorder

  • Toll-like receptor 4 (TLR4) is activated by lipopolysaccharide (LPS), with LPS-binding protein, to initiate an innate immune response, which typically includes increased expression of TNFα.{28195} TLR4-C34 is a 2-acetamidopyranoside that inhibits TLR4 signaling in enterocytes and macrophages in vitro when used at 10 µM.{29731,29732} It does not affect signaling through either TLR2 or TLR9. TLR4-C34, used at 1 mg/kg in vivo, also reduces systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis.{29731} It markedly decreases the basal expression of TNFα, as well as LPS-induced iNOS and TNFα expression, in intestinal tissue isolated from patients with necrotizing enterocolitis.{29731}  

     

    Brand:
    Cayman
    SKU:-

    Available on backorder

  • Toll-like receptor 4 (TLR4) is activated by lipopolysaccharide (LPS), with LPS-binding protein, to initiate an innate immune response, which typically includes increased expression of TNFα.{28195} TLR4-C34 is a 2-acetamidopyranoside that inhibits TLR4 signaling in enterocytes and macrophages in vitro when used at 10 µM.{29731,29732} It does not affect signaling through either TLR2 or TLR9. TLR4-C34, used at 1 mg/kg in vivo, also reduces systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis.{29731} It markedly decreases the basal expression of TNFα, as well as LPS-induced iNOS and TNFα expression, in intestinal tissue isolated from patients with necrotizing enterocolitis.{29731}  

     

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    Cayman
    SKU:-

    Available on backorder

  • TLR agonist 2 is a toll-like receptor 7 (TLR7) agonist with a lowest effective concentration (LEC) value of 0.4 μM in a cell-based reporter assay.{54116} It is selective for TLR7 over TLR8 (LEC = >100 μM). TLR7 agonist 2 (0.3-10 mg/kg) increases IFN-α levels and the IFN-stimulated gene (ISG) response, increasing the expression of Oas1b, Isg15, and Mx1, in mouse liver and plasma. It increases plasma levels of IFN-α, CCL2, IL-6, IL-1Ra, G-CSF, and IL-10 in cynomolgus monkeys when administered at a dose of 10 mg/kg. TLR agonist 2 (0.3-5 mg/kg) reduces serum and liver viral load in the hydrodynamic injection (HDI) hepatitis B virus (HBV) mouse model.  

     

    Brand:
    Cayman
    SKU:28450 - 1 mg

    Available on backorder

  • TLR agonist 2 is a toll-like receptor 7 (TLR7) agonist with a lowest effective concentration (LEC) value of 0.4 μM in a cell-based reporter assay.{54116} It is selective for TLR7 over TLR8 (LEC = >100 μM). TLR7 agonist 2 (0.3-10 mg/kg) increases IFN-α levels and the IFN-stimulated gene (ISG) response, increasing the expression of Oas1b, Isg15, and Mx1, in mouse liver and plasma. It increases plasma levels of IFN-α, CCL2, IL-6, IL-1Ra, G-CSF, and IL-10 in cynomolgus monkeys when administered at a dose of 10 mg/kg. TLR agonist 2 (0.3-5 mg/kg) reduces serum and liver viral load in the hydrodynamic injection (HDI) hepatitis B virus (HBV) mouse model.  

     

    Brand:
    Cayman
    SKU:28450 - 10 mg

    Available on backorder

  • TLR agonist 2 is a toll-like receptor 7 (TLR7) agonist with a lowest effective concentration (LEC) value of 0.4 μM in a cell-based reporter assay.{54116} It is selective for TLR7 over TLR8 (LEC = >100 μM). TLR7 agonist 2 (0.3-10 mg/kg) increases IFN-α levels and the IFN-stimulated gene (ISG) response, increasing the expression of Oas1b, Isg15, and Mx1, in mouse liver and plasma. It increases plasma levels of IFN-α, CCL2, IL-6, IL-1Ra, G-CSF, and IL-10 in cynomolgus monkeys when administered at a dose of 10 mg/kg. TLR agonist 2 (0.3-5 mg/kg) reduces serum and liver viral load in the hydrodynamic injection (HDI) hepatitis B virus (HBV) mouse model.  

     

    Brand:
    Cayman
    SKU:28450 - 5 mg

    Available on backorder

  • TLR7/8 agonist 1 is a dual agonist of toll-like receptor 7 (TLR7) and TLR8 (EC50s = 50 and 55 nM, respectively, in cell-based assays).{47662} It increases the levels of TNF-α, IFN-γ, IL-12p40, and chemokine (C-C motif) ligand 4 (CCL4) in human peripheral blood mononuclear cells (PBMCs) in a biphasic manner. TLR7/8 agonist 1 (25 nmol, s.c.) increases serum levels of IL-12p40 and chemokine (C-X-C motif) ligand 10 (CXCL10), as well as the number of dendritic cells per injection-site proximal lymph node, in mice.{47663} It has been conjugated to various fluorophores as TLR7 probes and to polymer particles for the modulation of TLR7/8 agonist 1 adjuvant activity.{47664,47663}  

     

    Brand:
    Cayman
    SKU:28451 - 1 mg

    Available on backorder

  • TLR7/8 agonist 1 is a dual agonist of toll-like receptor 7 (TLR7) and TLR8 (EC50s = 50 and 55 nM, respectively, in cell-based assays).{47662} It increases the levels of TNF-α, IFN-γ, IL-12p40, and chemokine (C-C motif) ligand 4 (CCL4) in human peripheral blood mononuclear cells (PBMCs) in a biphasic manner. TLR7/8 agonist 1 (25 nmol, s.c.) increases serum levels of IL-12p40 and chemokine (C-X-C motif) ligand 10 (CXCL10), as well as the number of dendritic cells per injection-site proximal lymph node, in mice.{47663} It has been conjugated to various fluorophores as TLR7 probes and to polymer particles for the modulation of TLR7/8 agonist 1 adjuvant activity.{47664,47663}  

     

    Brand:
    Cayman
    SKU:28451 - 5 mg

    Available on backorder

  • TLR7/8 agonist 1 is a dual agonist of toll-like receptor 7 (TLR7) and TLR8 (EC50s = 50 and 55 nM, respectively, in cell-based assays).{47662} It increases the levels of TNF-α, IFN-γ, IL-12p40, and chemokine (C-C motif) ligand 4 (CCL4) in human peripheral blood mononuclear cells (PBMCs) in a biphasic manner. TLR7/8 agonist 1 (25 nmol, s.c.) increases serum levels of IL-12p40 and chemokine (C-X-C motif) ligand 10 (CXCL10), as well as the number of dendritic cells per injection-site proximal lymph node, in mice.{47663} It has been conjugated to various fluorophores as TLR7 probes and to polymer particles for the modulation of TLR7/8 agonist 1 adjuvant activity.{47664,47663}  

     

    Brand:
    Cayman
    SKU:28451 - 500 µg

    Available on backorder

  • TM5275 is an inhibitor of plasminogen activator inhibitor 1 (PAI-1; IC50 = 6.95 µM), a serine-protease inhibitor involved in thrombosis.{39402} TM5275 inhibits formation of a complex consisting of tissue plasminogen activator (tPA), PAI-1, and GFP on vascular endothelial cells (VECs) in vitro, prolonging the time that tPA is retained on VECs.{39403} It also enhances fibrin clot dissolution and plasminogen accumulation in vitro and has antithrombotic effects in rat models of thrombosis.{39402} TM5275 (10 and 50 mg/kg) decreases blood clot weight in an arteriovenous shunt thrombosis model and increases the time to primary occlusion in a ferric chloride-treated carotid artery thrombosis model when used at doses of 1 and 3 mg/kg. In a cynomolgus monkey model of photochemical-induced arterial thrombosis, TM5275 (10 mg/kg) increases the time to primary occlusion. It does not affect platelet activity, activated partial thromboplastin time, prothrombin time, or prolong bleeding time.  

     

    Brand:
    Cayman
    SKU:23151 - 1 mg

    Available on backorder

  • TM5275 is an inhibitor of plasminogen activator inhibitor 1 (PAI-1; IC50 = 6.95 µM), a serine-protease inhibitor involved in thrombosis.{39402} TM5275 inhibits formation of a complex consisting of tissue plasminogen activator (tPA), PAI-1, and GFP on vascular endothelial cells (VECs) in vitro, prolonging the time that tPA is retained on VECs.{39403} It also enhances fibrin clot dissolution and plasminogen accumulation in vitro and has antithrombotic effects in rat models of thrombosis.{39402} TM5275 (10 and 50 mg/kg) decreases blood clot weight in an arteriovenous shunt thrombosis model and increases the time to primary occlusion in a ferric chloride-treated carotid artery thrombosis model when used at doses of 1 and 3 mg/kg. In a cynomolgus monkey model of photochemical-induced arterial thrombosis, TM5275 (10 mg/kg) increases the time to primary occlusion. It does not affect platelet activity, activated partial thromboplastin time, prothrombin time, or prolong bleeding time.  

     

    Brand:
    Cayman
    SKU:23151 - 10 mg

    Available on backorder

  • TM5275 is an inhibitor of plasminogen activator inhibitor 1 (PAI-1; IC50 = 6.95 µM), a serine-protease inhibitor involved in thrombosis.{39402} TM5275 inhibits formation of a complex consisting of tissue plasminogen activator (tPA), PAI-1, and GFP on vascular endothelial cells (VECs) in vitro, prolonging the time that tPA is retained on VECs.{39403} It also enhances fibrin clot dissolution and plasminogen accumulation in vitro and has antithrombotic effects in rat models of thrombosis.{39402} TM5275 (10 and 50 mg/kg) decreases blood clot weight in an arteriovenous shunt thrombosis model and increases the time to primary occlusion in a ferric chloride-treated carotid artery thrombosis model when used at doses of 1 and 3 mg/kg. In a cynomolgus monkey model of photochemical-induced arterial thrombosis, TM5275 (10 mg/kg) increases the time to primary occlusion. It does not affect platelet activity, activated partial thromboplastin time, prothrombin time, or prolong bleeding time.  

     

    Brand:
    Cayman
    SKU:23151 - 25 mg

    Available on backorder

  • TM5275 is an inhibitor of plasminogen activator inhibitor 1 (PAI-1; IC50 = 6.95 µM), a serine-protease inhibitor involved in thrombosis.{39402} TM5275 inhibits formation of a complex consisting of tissue plasminogen activator (tPA), PAI-1, and GFP on vascular endothelial cells (VECs) in vitro, prolonging the time that tPA is retained on VECs.{39403} It also enhances fibrin clot dissolution and plasminogen accumulation in vitro and has antithrombotic effects in rat models of thrombosis.{39402} TM5275 (10 and 50 mg/kg) decreases blood clot weight in an arteriovenous shunt thrombosis model and increases the time to primary occlusion in a ferric chloride-treated carotid artery thrombosis model when used at doses of 1 and 3 mg/kg. In a cynomolgus monkey model of photochemical-induced arterial thrombosis, TM5275 (10 mg/kg) increases the time to primary occlusion. It does not affect platelet activity, activated partial thromboplastin time, prothrombin time, or prolong bleeding time.  

     

    Brand:
    Cayman
    SKU:23151 - 5 mg

    Available on backorder

  • TM5441 is an orally bioavailable inhibitor of plasminogen activator inhibitor 1 (PAI-1), a serine-protease inhibitor involved in thrombosis.{37397,37395} It decreases survival of HT1080, HCT116, Daoy, MDA-MB-231, and Jurkat cancer cells with IC50 values ranging from 13.9 to 51.1 µM.{37397} TM5441 inhibits branching of human umbilical vein endothelial cells (HUVECs) in a vasculature assay in vitro when used at a concentration of 50 µM but does not affect HUVEC survival or apoptosis. It also disrupts tumor vasculature in HT1080 and HCT116 mouse xenograft models when used at a dose of 20 mg/kg per day. TM5441 prevents hypertension and cardiac hypertrophy and reduces periaortic fibrosis induced by L-NAME (Item No. 80210).{37395} It protects against high-fat diet-induced non-alcoholic fatty liver disease (NAFLD) in mice when administered concurrently with a high-fat diet or after glucose tolerance has developed.{37398} TM5441 also increases median lifespan by 4-fold and reduces signs of senescence in Klotho-deficient mice, a mouse model of aging.{37396}  

     

    Brand:
    Cayman
    SKU:22965 - 1 mg

    Available on backorder

  • TM5441 is an orally bioavailable inhibitor of plasminogen activator inhibitor 1 (PAI-1), a serine-protease inhibitor involved in thrombosis.{37397,37395} It decreases survival of HT1080, HCT116, Daoy, MDA-MB-231, and Jurkat cancer cells with IC50 values ranging from 13.9 to 51.1 µM.{37397} TM5441 inhibits branching of human umbilical vein endothelial cells (HUVECs) in a vasculature assay in vitro when used at a concentration of 50 µM but does not affect HUVEC survival or apoptosis. It also disrupts tumor vasculature in HT1080 and HCT116 mouse xenograft models when used at a dose of 20 mg/kg per day. TM5441 prevents hypertension and cardiac hypertrophy and reduces periaortic fibrosis induced by L-NAME (Item No. 80210).{37395} It protects against high-fat diet-induced non-alcoholic fatty liver disease (NAFLD) in mice when administered concurrently with a high-fat diet or after glucose tolerance has developed.{37398} TM5441 also increases median lifespan by 4-fold and reduces signs of senescence in Klotho-deficient mice, a mouse model of aging.{37396}  

     

    Brand:
    Cayman
    SKU:22965 - 10 mg

    Available on backorder

  • TM5441 is an orally bioavailable inhibitor of plasminogen activator inhibitor 1 (PAI-1), a serine-protease inhibitor involved in thrombosis.{37397,37395} It decreases survival of HT1080, HCT116, Daoy, MDA-MB-231, and Jurkat cancer cells with IC50 values ranging from 13.9 to 51.1 µM.{37397} TM5441 inhibits branching of human umbilical vein endothelial cells (HUVECs) in a vasculature assay in vitro when used at a concentration of 50 µM but does not affect HUVEC survival or apoptosis. It also disrupts tumor vasculature in HT1080 and HCT116 mouse xenograft models when used at a dose of 20 mg/kg per day. TM5441 prevents hypertension and cardiac hypertrophy and reduces periaortic fibrosis induced by L-NAME (Item No. 80210).{37395} It protects against high-fat diet-induced non-alcoholic fatty liver disease (NAFLD) in mice when administered concurrently with a high-fat diet or after glucose tolerance has developed.{37398} TM5441 also increases median lifespan by 4-fold and reduces signs of senescence in Klotho-deficient mice, a mouse model of aging.{37396}  

     

    Brand:
    Cayman
    SKU:22965 - 5 mg

    Available on backorder

  • TMA-DPH is a fluorescent probe used for measuring membrane fluidity in artificial and living membrane systems.{28346,28344,28345,28343} The cylindrical shape of TMA-DPH confers high sensitivity to reorientation resulting from changes in surrounding lipids. TMA-DPH has excitation and emission maxima at 355 and 430 nm, respectively.  

     

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    Cayman
    SKU:-

    Available on backorder

  • TMA-DPH is a fluorescent probe used for measuring membrane fluidity in artificial and living membrane systems.{28346,28344,28345,28343} The cylindrical shape of TMA-DPH confers high sensitivity to reorientation resulting from changes in surrounding lipids. TMA-DPH has excitation and emission maxima at 355 and 430 nm, respectively.  

     

    Brand:
    Cayman
    SKU:-

    Available on backorder

  • TMA-DPH is a fluorescent probe used for measuring membrane fluidity in artificial and living membrane systems.{28346,28344,28345,28343} The cylindrical shape of TMA-DPH confers high sensitivity to reorientation resulting from changes in surrounding lipids. TMA-DPH has excitation and emission maxima at 355 and 430 nm, respectively.  

     

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    Cayman
    SKU:-

    Available on backorder

  • TMB is an aromatic amine that undergoes oxidation by the higher oxidation states of heme peroxidases (compounds I and II) thereby serving as a reducing co-substrate. One electron oxidation of TMB results in a radical cation that forms a charge-transfer complex with the unoxidized compound. This charge transfer complex absorbs at 652 nm (ε = 39,000).{8111} The completely oxidized form (diimine) absorbs at 450 nm (ε = 59,000) and is formed by two sequential one-electron oxidations of TMB.{8111,8109} Thus the stoichiometry of oxidation is 0.5 mole charge transfer complex (λmax = 652 nm) or 1 mole of diimine (λmax = 450 nm) formed (or TMB oxidized) per mole of hydroperoxide reduced by the peroxidase.  

     

    Brand:
    Cayman
    SKU:70450 - 1 g

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  • TMB is an aromatic amine that undergoes oxidation by the higher oxidation states of heme peroxidases (compounds I and II) thereby serving as a reducing co-substrate. One electron oxidation of TMB results in a radical cation that forms a charge-transfer complex with the unoxidized compound. This charge transfer complex absorbs at 652 nm (ε = 39,000).{8111} The completely oxidized form (diimine) absorbs at 450 nm (ε = 59,000) and is formed by two sequential one-electron oxidations of TMB.{8111,8109} Thus the stoichiometry of oxidation is 0.5 mole charge transfer complex (λmax = 652 nm) or 1 mole of diimine (λmax = 450 nm) formed (or TMB oxidized) per mole of hydroperoxide reduced by the peroxidase.  

     

    Brand:
    Cayman
    SKU:70450 - 100 mg

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  • TMB is an aromatic amine that undergoes oxidation by the higher oxidation states of heme peroxidases (compounds I and II) thereby serving as a reducing co-substrate. One electron oxidation of TMB results in a radical cation that forms a charge-transfer complex with the unoxidized compound. This charge transfer complex absorbs at 652 nm (ε = 39,000).{8111} The completely oxidized form (diimine) absorbs at 450 nm (ε = 59,000) and is formed by two sequential one-electron oxidations of TMB.{8111,8109} Thus the stoichiometry of oxidation is 0.5 mole charge transfer complex (λmax = 652 nm) or 1 mole of diimine (λmax = 450 nm) formed (or TMB oxidized) per mole of hydroperoxide reduced by the peroxidase.  

     

    Brand:
    Cayman
    SKU:70450 - 250 mg

    Available on backorder

  • TMB is an aromatic amine that undergoes oxidation by the higher oxidation states of heme peroxidases (compounds I and II) thereby serving as a reducing co-substrate. One electron oxidation of TMB results in a radical cation that forms a charge-transfer complex with the unoxidized compound. This charge transfer complex absorbs at 652 nm (ε = 39,000).{8111} The completely oxidized form (diimine) absorbs at 450 nm (ε = 59,000) and is formed by two sequential one-electron oxidations of TMB.{8111,8109} Thus the stoichiometry of oxidation is 0.5 mole charge transfer complex (λmax = 652 nm) or 1 mole of diimine (λmax = 450 nm) formed (or TMB oxidized) per mole of hydroperoxide reduced by the peroxidase.  

     

    Brand:
    Cayman
    SKU:70450 - 5 g

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  • TMB 8 is a non-competitive antagonist of nicotinic acetylcholine receptors (nAChRs) with IC50 values of 390 and 350 nM, respectively, for human muscle-type and α3β4 subunit-containing ganglionic nAChRs expressed in TE671/RD or SH-SY5Y cells.{38552} It inhibits nicotine-induced dopamine release from rat brain synaptosomes (IC50 = 480 nM). TMB 8 also reduces calcium availability in smooth and skeletal muscle, blocking the contractile response in isolated rabbit aortic strip when used at a concentration of 50 µM and inhibiting calcium influx and efflux in isolated guinea pig ileum when used at a concentration of 65 µM.{38553} It has been used in the study of intracellular calcium dynamics, particularly in smooth muscle.{38554,38555} TMB 8 also inhibits protein kinase C (PKC) activity in a dose-dependent manner.{38556}  

     

    Brand:
    Cayman
    SKU:23928 - 10 mg

    Available on backorder

  • TMB 8 is a non-competitive antagonist of nicotinic acetylcholine receptors (nAChRs) with IC50 values of 390 and 350 nM, respectively, for human muscle-type and α3β4 subunit-containing ganglionic nAChRs expressed in TE671/RD or SH-SY5Y cells.{38552} It inhibits nicotine-induced dopamine release from rat brain synaptosomes (IC50 = 480 nM). TMB 8 also reduces calcium availability in smooth and skeletal muscle, blocking the contractile response in isolated rabbit aortic strip when used at a concentration of 50 µM and inhibiting calcium influx and efflux in isolated guinea pig ileum when used at a concentration of 65 µM.{38553} It has been used in the study of intracellular calcium dynamics, particularly in smooth muscle.{38554,38555} TMB 8 also inhibits protein kinase C (PKC) activity in a dose-dependent manner.{38556}  

     

    Brand:
    Cayman
    SKU:23928 - 5 mg

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  • TMC207 is a diarylquinoline that selectively inhibits the proton pump of the mycobacterial ATP synthase.{31976} It demonstrates potent activity against both drug-sensitive and drug-resistant M. tuberculosis and other mycobacterial species with MIC50 values of ~0.03 µg/ml.{31976}  

     

    Brand:
    Cayman
    SKU:20247 -

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  • TMC207 is a diarylquinoline that selectively inhibits the proton pump of the mycobacterial ATP synthase.{31976} It demonstrates potent activity against both drug-sensitive and drug-resistant M. tuberculosis and other mycobacterial species with MIC50 values of ~0.03 µg/ml.{31976}  

     

    Brand:
    Cayman
    SKU:20247 -

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  • TMC207 is a diarylquinoline that selectively inhibits the proton pump of the mycobacterial ATP synthase.{31976} It demonstrates potent activity against both drug-sensitive and drug-resistant M. tuberculosis and other mycobacterial species with MIC50 values of ~0.03 µg/ml.{31976}  

     

    Brand:
    Cayman
    SKU:20247 -

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  • TMC207 is a diarylquinoline that selectively inhibits the proton pump of the mycobacterial ATP synthase.{31976} It demonstrates potent activity against both drug-sensitive and drug-resistant M. tuberculosis and other mycobacterial species with MIC50 values of ~0.03 µg/ml.{31976}  

     

    Brand:
    Cayman
    SKU:20247 -

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  • TMCB is a dual inhibitor of casein kinase 2 (CK2) and ERK8 (IC50 = 0.5 µM for both).{22896} It also binds to Pim-1, HIPK2, and DYRK1A (Kis = 8.65, 15.25, and 11.9 µM, respectively) and inhibits greater than 50% of the activity of five kinases, including CK2, ERK8, and DYRK2, in a panel of 78 kinases at 10 µM. TMCB induces apoptosis in Jurkat cells when used at concentrations ranging from 10 to 50 µM.  

     

    Brand:
    Cayman
    SKU:27652 - 10 mg

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  • TMCB is a dual inhibitor of casein kinase 2 (CK2) and ERK8 (IC50 = 0.5 µM for both).{22896} It also binds to Pim-1, HIPK2, and DYRK1A (Kis = 8.65, 15.25, and 11.9 µM, respectively) and inhibits greater than 50% of the activity of five kinases, including CK2, ERK8, and DYRK2, in a panel of 78 kinases at 10 µM. TMCB induces apoptosis in Jurkat cells when used at concentrations ranging from 10 to 50 µM.  

     

    Brand:
    Cayman
    SKU:27652 - 5 mg

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  • TMI 1 is an inhibitor of disintegrin and metalloproteinase domain-containing protein 17 (ADAM17/TACE; IC50 = 8.4 nM in a cell-free enzyme assay).{45715} It inhibits matrix metalloproteinase-1 (MMP-1), -2, -7, -9, -13, and -14, as well as ADAM-TS-4 in vitro (IC50s = 6.6, 4.7, 26, 12, 3, 26, and 100 nM, respectively). It also inhibits ADAM8, -10, -12, and -17/TACE in cell-free enzyme assays with Ki values of 21, 16, 1.8, and 0.079 nM, respectively, with slow-binding inhibition of ADAM17/TACE but not the other ADAM enzymes.{23492} TMI 1 inhibits LPS-induced TNF-α secretion in Raw and THP-1 cells (IC50s = 40 and 200 nM, respectively), as well as in isolated human monocytes and whole blood (IC50s = 190 and 300 nM, respectively).{45715} It inhibits the production of TNF-α ex vivo in synovium isolated from the inflamed joints of patients with rheumatoid arthritis with IC50 values of less than 100 nM without inhibiting TNF-α expression in vitro. TMI 1 inhibits LPS-induced TNF-α production in mice (ED50 = 5 mg/kg) and reduces disease severity in mouse models of collagen-induced arthritis. It also decreases cell viability of (ED50s = 1.3-8.1 µM), and induces caspase-3/7 activity in, a variety of cancer cell lines and induces tumor apoptosis and reduces tumor growth in an MMTV-ErbB2/neu mouse model of breast cancer when administered at a dose of 100 mg/kg.{45716}  

     

    Brand:
    Cayman
    SKU:29713 - 10 mg

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  • TMI 1 is an inhibitor of disintegrin and metalloproteinase domain-containing protein 17 (ADAM17/TACE; IC50 = 8.4 nM in a cell-free enzyme assay).{45715} It inhibits matrix metalloproteinase-1 (MMP-1), -2, -7, -9, -13, and -14, as well as ADAM-TS-4 in vitro (IC50s = 6.6, 4.7, 26, 12, 3, 26, and 100 nM, respectively). It also inhibits ADAM8, -10, -12, and -17/TACE in cell-free enzyme assays with Ki values of 21, 16, 1.8, and 0.079 nM, respectively, with slow-binding inhibition of ADAM17/TACE but not the other ADAM enzymes.{23492} TMI 1 inhibits LPS-induced TNF-α secretion in Raw and THP-1 cells (IC50s = 40 and 200 nM, respectively), as well as in isolated human monocytes and whole blood (IC50s = 190 and 300 nM, respectively).{45715} It inhibits the production of TNF-α ex vivo in synovium isolated from the inflamed joints of patients with rheumatoid arthritis with IC50 values of less than 100 nM without inhibiting TNF-α expression in vitro. TMI 1 inhibits LPS-induced TNF-α production in mice (ED50 = 5 mg/kg) and reduces disease severity in mouse models of collagen-induced arthritis. It also decreases cell viability of (ED50s = 1.3-8.1 µM), and induces caspase-3/7 activity in, a variety of cancer cell lines and induces tumor apoptosis and reduces tumor growth in an MMTV-ErbB2/neu mouse model of breast cancer when administered at a dose of 100 mg/kg.{45716}  

     

    Brand:
    Cayman
    SKU:29713 - 5 mg

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  • TMI-005 is an inhibitor of disintegrin and metalloproteinase domain-containing protein 17/TNF-α converting enzyme (ADAM17/TACE), matrix metalloproteinase-1 (MMP-1), and MMP-13 (IC50s = 20, 33, and 8.1 nM, respectively).{45590} It inhibits LPS-induced TNF-α release in isolated human whole blood (IC50 = 144 ng/ml).{45591} TMI-005 (25 μM) reduces basal and ionizing radiation-induced secretion of the ADAM17/TACE substrates ALCAM and amphiregulin from A549 and NCI H125 cells.{45592} It inhibits proliferation of A549 cells when used at concentrations of 25 and 50 μM and sensitizes A549 and NCI H125 cells to ionizing radiation at 25 μM. TMI-005 (25 mg/kg twice per day) reduces tumor growth in an A549 mouse xenograft model when administered in combination with ionizing radiation.  

     

    Brand:
    Cayman
    SKU:29016 - 1 mg

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  • TMI-005 is an inhibitor of disintegrin and metalloproteinase domain-containing protein 17/TNF-α converting enzyme (ADAM17/TACE), matrix metalloproteinase-1 (MMP-1), and MMP-13 (IC50s = 20, 33, and 8.1 nM, respectively).{45590} It inhibits LPS-induced TNF-α release in isolated human whole blood (IC50 = 144 ng/ml).{45591} TMI-005 (25 μM) reduces basal and ionizing radiation-induced secretion of the ADAM17/TACE substrates ALCAM and amphiregulin from A549 and NCI H125 cells.{45592} It inhibits proliferation of A549 cells when used at concentrations of 25 and 50 μM and sensitizes A549 and NCI H125 cells to ionizing radiation at 25 μM. TMI-005 (25 mg/kg twice per day) reduces tumor growth in an A549 mouse xenograft model when administered in combination with ionizing radiation.  

     

    Brand:
    Cayman
    SKU:29016 - 10 mg

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  • TMI-005 is an inhibitor of disintegrin and metalloproteinase domain-containing protein 17/TNF-α converting enzyme (ADAM17/TACE), matrix metalloproteinase-1 (MMP-1), and MMP-13 (IC50s = 20, 33, and 8.1 nM, respectively).{45590} It inhibits LPS-induced TNF-α release in isolated human whole blood (IC50 = 144 ng/ml).{45591} TMI-005 (25 μM) reduces basal and ionizing radiation-induced secretion of the ADAM17/TACE substrates ALCAM and amphiregulin from A549 and NCI H125 cells.{45592} It inhibits proliferation of A549 cells when used at concentrations of 25 and 50 μM and sensitizes A549 and NCI H125 cells to ionizing radiation at 25 μM. TMI-005 (25 mg/kg twice per day) reduces tumor growth in an A549 mouse xenograft model when administered in combination with ionizing radiation.  

     

    Brand:
    Cayman
    SKU:29016 - 5 mg

    Available on backorder

  • TMN 355 is an inhibitor of cyclophilin A (IC50 = 1.52 nM).{52619} It inhibits HIV-1 pseudoparticle infection of HEK293/T-17 cells when used at concentrations ranging from 0.1 to 1 µM.{52620}  

     

    Brand:
    Cayman
    SKU:31155 - 10 mg

    Available on backorder

  • TMN 355 is an inhibitor of cyclophilin A (IC50 = 1.52 nM).{52619} It inhibits HIV-1 pseudoparticle infection of HEK293/T-17 cells when used at concentrations ranging from 0.1 to 1 µM.{52620}  

     

    Brand:
    Cayman
    SKU:31155 - 5 mg

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  • Acyl-CoA:cholesterol acyltransferase (ACAT) catalyses the esterification of excess cellular cholesterol with fatty acids and is important for intestinal cholesterol absorption, hepatic lipoprotein secretion, and cholesterol accumulation in vascular tissues. ACAT inhibitors improve plasma lipid profile and ameliorate proteinuria in nephrotic animals.{20948} TMP-153 is a quinolyl derivative that inhibits ACAT with IC50 values of 5-10 nM in various animals.{20942} At 0.5-1.5 mg/kg, TMP-153 dose-dependently reduces plasma total- and low density lipoprotein cholesterol without affecting high density lipoprotein cholesterol in hamsters.{20942} It inhibits cholesterol esterification both in human colonic adenocarcinoma L S180 cells and in human hepatoma HepG2 cells (IC50s = 150 and 330 nM, respectively).{20941} When fed as a dietary supplement (ED50 = 0.81 mg/kg/day), TMP-153 reduces hepatic cholesterogenesis in hamsters fed a stock diet.{20941}  

     

    Brand:
    Cayman
    SKU:10010516 - 10 mg

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  • Acyl-CoA:cholesterol acyltransferase (ACAT) catalyses the esterification of excess cellular cholesterol with fatty acids and is important for intestinal cholesterol absorption, hepatic lipoprotein secretion, and cholesterol accumulation in vascular tissues. ACAT inhibitors improve plasma lipid profile and ameliorate proteinuria in nephrotic animals.{20948} TMP-153 is a quinolyl derivative that inhibits ACAT with IC50 values of 5-10 nM in various animals.{20942} At 0.5-1.5 mg/kg, TMP-153 dose-dependently reduces plasma total- and low density lipoprotein cholesterol without affecting high density lipoprotein cholesterol in hamsters.{20942} It inhibits cholesterol esterification both in human colonic adenocarcinoma L S180 cells and in human hepatoma HepG2 cells (IC50s = 150 and 330 nM, respectively).{20941} When fed as a dietary supplement (ED50 = 0.81 mg/kg/day), TMP-153 reduces hepatic cholesterogenesis in hamsters fed a stock diet.{20941}  

     

    Brand:
    Cayman
    SKU:10010516 - 25 mg

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  • Acyl-CoA:cholesterol acyltransferase (ACAT) catalyses the esterification of excess cellular cholesterol with fatty acids and is important for intestinal cholesterol absorption, hepatic lipoprotein secretion, and cholesterol accumulation in vascular tissues. ACAT inhibitors improve plasma lipid profile and ameliorate proteinuria in nephrotic animals.{20948} TMP-153 is a quinolyl derivative that inhibits ACAT with IC50 values of 5-10 nM in various animals.{20942} At 0.5-1.5 mg/kg, TMP-153 dose-dependently reduces plasma total- and low density lipoprotein cholesterol without affecting high density lipoprotein cholesterol in hamsters.{20942} It inhibits cholesterol esterification both in human colonic adenocarcinoma L S180 cells and in human hepatoma HepG2 cells (IC50s = 150 and 330 nM, respectively).{20941} When fed as a dietary supplement (ED50 = 0.81 mg/kg/day), TMP-153 reduces hepatic cholesterogenesis in hamsters fed a stock diet.{20941}  

     

    Brand:
    Cayman
    SKU:10010516 - 5 mg

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  • TMP-195 is an inhibitor of class IIa histone deacetylases (HDACs; Kis = 59, 60, 26, and 15 nM for HDAC4, 5, 7, and 9, respectively).{28861} It is selective for class IIa HDACs over class I and class IIb HDACs (Kis = 10-43 μM for HDAC1-3, 6, 9, and 10-11). TMP-195 blocks accumulation of chemoattractant chemokine ligand 2 (CCL2) in the supernatant of monocytes stimulated with macrophage colony-stimulating factor (CSF-1). It increases secretion of CCL1 by monocytes stimulated with CSF-1 and granulocyte/monocyte colony-stimulating factor (GM-CSF). In vivo, TMP-195 reduces tumor burden and the number of pulmonary metastases in a macrophage-dependent autochthonous mouse model of breast cancer.{42136}  

     

    Brand:
    Cayman
    SKU:23242 - 1 mg

    Available on backorder

  • TMP-195 is an inhibitor of class IIa histone deacetylases (HDACs; Kis = 59, 60, 26, and 15 nM for HDAC4, 5, 7, and 9, respectively).{28861} It is selective for class IIa HDACs over class I and class IIb HDACs (Kis = 10-43 μM for HDAC1-3, 6, 9, and 10-11). TMP-195 blocks accumulation of chemoattractant chemokine ligand 2 (CCL2) in the supernatant of monocytes stimulated with macrophage colony-stimulating factor (CSF-1). It increases secretion of CCL1 by monocytes stimulated with CSF-1 and granulocyte/monocyte colony-stimulating factor (GM-CSF). In vivo, TMP-195 reduces tumor burden and the number of pulmonary metastases in a macrophage-dependent autochthonous mouse model of breast cancer.{42136}  

     

    Brand:
    Cayman
    SKU:23242 - 10 mg

    Available on backorder

  • TMP-195 is an inhibitor of class IIa histone deacetylases (HDACs; Kis = 59, 60, 26, and 15 nM for HDAC4, 5, 7, and 9, respectively).{28861} It is selective for class IIa HDACs over class I and class IIb HDACs (Kis = 10-43 μM for HDAC1-3, 6, 9, and 10-11). TMP-195 blocks accumulation of chemoattractant chemokine ligand 2 (CCL2) in the supernatant of monocytes stimulated with macrophage colony-stimulating factor (CSF-1). It increases secretion of CCL1 by monocytes stimulated with CSF-1 and granulocyte/monocyte colony-stimulating factor (GM-CSF). In vivo, TMP-195 reduces tumor burden and the number of pulmonary metastases in a macrophage-dependent autochthonous mouse model of breast cancer.{42136}  

     

    Brand:
    Cayman
    SKU:23242 - 25 mg

    Available on backorder

  • TMP-195 is an inhibitor of class IIa histone deacetylases (HDACs; Kis = 59, 60, 26, and 15 nM for HDAC4, 5, 7, and 9, respectively).{28861} It is selective for class IIa HDACs over class I and class IIb HDACs (Kis = 10-43 μM for HDAC1-3, 6, 9, and 10-11). TMP-195 blocks accumulation of chemoattractant chemokine ligand 2 (CCL2) in the supernatant of monocytes stimulated with macrophage colony-stimulating factor (CSF-1). It increases secretion of CCL1 by monocytes stimulated with CSF-1 and granulocyte/monocyte colony-stimulating factor (GM-CSF). In vivo, TMP-195 reduces tumor burden and the number of pulmonary metastases in a macrophage-dependent autochthonous mouse model of breast cancer.{42136}  

     

    Brand:
    Cayman
    SKU:23242 - 5 mg

    Available on backorder

  • While class I HDACs are localized predominantly within the nucleus, class II HDACs shuttle into and out of the nucleus in response to intracellular signaling.{26846} Class IIa HDACs, which include HDAC4, 5, 7, and 9, commonly act as corepressors and play diverse roles in cell biology.{22864} TMP269 is a cell-permeable inhibitor of class IIa HDACs (IC50s = 126, 80, 36, and 19 nM for HDAC4, 5, 7, and 9, respectively).{28861} It contains a metal-binding group, trifluoromethyloxadiazole that confers selectivity for class IIa HDACs.{28861}  

     

    Brand:
    Cayman
    SKU:-

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  • While class I HDACs are localized predominantly within the nucleus, class II HDACs shuttle into and out of the nucleus in response to intracellular signaling.{26846} Class IIa HDACs, which include HDAC4, 5, 7, and 9, commonly act as corepressors and play diverse roles in cell biology.{22864} TMP269 is a cell-permeable inhibitor of class IIa HDACs (IC50s = 126, 80, 36, and 19 nM for HDAC4, 5, 7, and 9, respectively).{28861} It contains a metal-binding group, trifluoromethyloxadiazole that confers selectivity for class IIa HDACs.{28861}  

     

    Brand:
    Cayman
    SKU:-

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  • While class I HDACs are localized predominantly within the nucleus, class II HDACs shuttle into and out of the nucleus in response to intracellular signaling.{26846} Class IIa HDACs, which include HDAC4, 5, 7, and 9, commonly act as corepressors and play diverse roles in cell biology.{22864} TMP269 is a cell-permeable inhibitor of class IIa HDACs (IC50s = 126, 80, 36, and 19 nM for HDAC4, 5, 7, and 9, respectively).{28861} It contains a metal-binding group, trifluoromethyloxadiazole that confers selectivity for class IIa HDACs.{28861}  

     

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    Cayman
    SKU:-

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  • TMPD is an easily oxidizable compound that serves as a reducing co-substrate for heme peroxidases.{8584} TMPD undergoes one-electron oxidation by the heme peroxidase higher oxidation states (compounds I and II) producing a highly colored product that absorbs at 611 nm.{8581} Thus, the stoichiometry of oxidation is 2 moles of TMPD oxidized per mole of hydroperoxide reduced by the peroxidase. The extinction coefficient of the oxidized TMPD at 611 nm is 12,200.{8581} TMPD is also used for the detection of peroxidases on polyacrylamide gels.{8585}  

     

    Brand:
    Cayman
    SKU:70455 - 10 g

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  • TMPD is an easily oxidizable compound that serves as a reducing co-substrate for heme peroxidases.{8584} TMPD undergoes one-electron oxidation by the heme peroxidase higher oxidation states (compounds I and II) producing a highly colored product that absorbs at 611 nm.{8581} Thus, the stoichiometry of oxidation is 2 moles of TMPD oxidized per mole of hydroperoxide reduced by the peroxidase. The extinction coefficient of the oxidized TMPD at 611 nm is 12,200.{8581} TMPD is also used for the detection of peroxidases on polyacrylamide gels.{8585}  

     

    Brand:
    Cayman
    SKU:70455 - 25 g

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  • TMPD is an easily oxidizable compound that serves as a reducing co-substrate for heme peroxidases.{8584} TMPD undergoes one-electron oxidation by the heme peroxidase higher oxidation states (compounds I and II) producing a highly colored product that absorbs at 611 nm.{8581} Thus, the stoichiometry of oxidation is 2 moles of TMPD oxidized per mole of hydroperoxide reduced by the peroxidase. The extinction coefficient of the oxidized TMPD at 611 nm is 12,200.{8581} TMPD is also used for the detection of peroxidases on polyacrylamide gels.{8585}  

     

    Brand:
    Cayman
    SKU:70455 - 5 g

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  • TMPD is an easily oxidizable compound that serves as a reducing co-substrate for heme peroxidases.{8584} TMPD undergoes one-electron oxidation by the heme peroxidase higher oxidation states (compounds I and II) producing a highly colored product that absorbs at 611 nm.{8581} Thus, the stoichiometry of oxidation is 2 moles of TMPD oxidized per mole of hydroperoxide reduced by the peroxidase. The extinction coefficient of the oxidized TMPD at 611 nm is 12,200.{8581} TMPD is also used for the detection of peroxidases on polyacrylamide gels.{8585}  

     

    Brand:
    Cayman
    SKU:70455 - 50 g

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  • TMPyP4 is a cationic porphyrin that intercalates into and stabilizes G-quadruplexes, which are formed by DNA and RNA sequences composed of blocks of guanine residues.{29692} In this way, TMPyP4 inhibits telomerase activity (IC50 ≤ 50 µM), blocking the clonogenic growth and migration of cancer cells in culture and in vivo.{29694,29695,29696} TMPyP4 also inhibits acetylcholinesterase at doses of 0.1 to 1.0 mM.{29693}  

     

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    Cayman
    SKU:-

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  • TMPyP4 is a cationic porphyrin that intercalates into and stabilizes G-quadruplexes, which are formed by DNA and RNA sequences composed of blocks of guanine residues.{29692} In this way, TMPyP4 inhibits telomerase activity (IC50 ≤ 50 µM), blocking the clonogenic growth and migration of cancer cells in culture and in vivo.{29694,29695,29696} TMPyP4 also inhibits acetylcholinesterase at doses of 0.1 to 1.0 mM.{29693}  

     

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    Cayman
    SKU:-

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  • TMPyP4 is a cationic porphyrin that intercalates into and stabilizes G-quadruplexes, which are formed by DNA and RNA sequences composed of blocks of guanine residues.{29692} In this way, TMPyP4 inhibits telomerase activity (IC50 ≤ 50 µM), blocking the clonogenic growth and migration of cancer cells in culture and in vivo.{29694,29695,29696} TMPyP4 also inhibits acetylcholinesterase at doses of 0.1 to 1.0 mM.{29693}  

     

    Brand:
    Cayman
    SKU:-

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  • TMPyP4 is a cationic porphyrin that intercalates into and stabilizes G-quadruplexes, which are formed by DNA and RNA sequences composed of blocks of guanine residues.{29692} In this way, TMPyP4 inhibits telomerase activity (IC50 ≤ 50 µM), blocking the clonogenic growth and migration of cancer cells in culture and in vivo.{29694,29695,29696} TMPyP4 also inhibits acetylcholinesterase at doses of 0.1 to 1.0 mM.{29693}  

     

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    Cayman
    SKU:-

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  • Cayman’s TMRE Mitochondrial Membrane Potential Assay Kit utilizes tetramethylrhodamine ethyl ester (TMRE), a cell permeable, cationic dye which accumulates in the mitochondrial matrix based on mitochondrial membrane potential (ΔψM). This assay, which is suitable for high-throughput screening, includes the mitochondrial uncoupler FCCP as a positive control for membrane depolarization.  

     

    Brand:
    Cayman
    SKU:701310 - 500 wells

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  • CYP1B1 is mainly an extrahepatic enzyme which oxidatively metabolizes both endogenous (steroids; eicosanoids) and exogenous xenobiotics such aspolyaromatic hydrocarbons. TMS is a potent and selective inhibitor of CYP1B1, with an IC50 of 6 nM.{10511} It is 50-fold selective for the inhibition of CYP1B1 versus CYP1A1, making it a useful tool to differentiate between various CYP450 families.{10511} In cultured human colon cancer cells, TMS induces apoptosis and inhibits cell growth with an IC50 of 0.8 µg/ml.{10510}  

     

    Brand:
    Cayman
    SKU:10038 - 1 mg

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  • CYP1B1 is mainly an extrahepatic enzyme which oxidatively metabolizes both endogenous (steroids; eicosanoids) and exogenous xenobiotics such aspolyaromatic hydrocarbons. TMS is a potent and selective inhibitor of CYP1B1, with an IC50 of 6 nM.{10511} It is 50-fold selective for the inhibition of CYP1B1 versus CYP1A1, making it a useful tool to differentiate between various CYP450 families.{10511} In cultured human colon cancer cells, TMS induces apoptosis and inhibits cell growth with an IC50 of 0.8 µg/ml.{10510}  

     

    Brand:
    Cayman
    SKU:10038 - 10 mg

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  • CYP1B1 is mainly an extrahepatic enzyme which oxidatively metabolizes both endogenous (steroids; eicosanoids) and exogenous xenobiotics such aspolyaromatic hydrocarbons. TMS is a potent and selective inhibitor of CYP1B1, with an IC50 of 6 nM.{10511} It is 50-fold selective for the inhibition of CYP1B1 versus CYP1A1, making it a useful tool to differentiate between various CYP450 families.{10511} In cultured human colon cancer cells, TMS induces apoptosis and inhibits cell growth with an IC50 of 0.8 µg/ml.{10510}  

     

    Brand:
    Cayman
    SKU:10038 - 5 mg

    Available on backorder

  • CYP1B1 is mainly an extrahepatic enzyme which oxidatively metabolizes both endogenous (steroids; eicosanoids) and exogenous xenobiotics such aspolyaromatic hydrocarbons. TMS is a potent and selective inhibitor of CYP1B1, with an IC50 of 6 nM.{10511} It is 50-fold selective for the inhibition of CYP1B1 versus CYP1A1, making it a useful tool to differentiate between various CYP450 families.{10511} In cultured human colon cancer cells, TMS induces apoptosis and inhibits cell growth with an IC50 of 0.8 µg/ml.{10510}  

     

    Brand:
    Cayman
    SKU:10038 - 50 mg

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  • TN-16 is an inhibitor of microtubule polymerization (IC50 = 0.4-1.7 µM).{33289} It blocks taxol-induced assembly of tubulin (IC50 = 6 µM) and blocks colchicine (Item No. 9000760) binding to tubulin.{33289} Like colchicine, TN-16 inhibits alkylation of tubulin.{33292} TN-16 induces metaphase arrest in renal cell carcinoma cells.{33291} TN-16 can be used in combination with other inhibitors to enhance the efficiency of human artificial chromosome transfer to recipient cells.{33290}  

     

    Brand:
    Cayman
    SKU:21222 -

    Out of stock

  • TN-16 is an inhibitor of microtubule polymerization (IC50 = 0.4-1.7 µM).{33289} It blocks taxol-induced assembly of tubulin (IC50 = 6 µM) and blocks colchicine (Item No. 9000760) binding to tubulin.{33289} Like colchicine, TN-16 inhibits alkylation of tubulin.{33292} TN-16 induces metaphase arrest in renal cell carcinoma cells.{33291} TN-16 can be used in combination with other inhibitors to enhance the efficiency of human artificial chromosome transfer to recipient cells.{33290}  

     

    Brand:
    Cayman
    SKU:21222 -

    Out of stock

  • TN-16 is an inhibitor of microtubule polymerization (IC50 = 0.4-1.7 µM).{33289} It blocks taxol-induced assembly of tubulin (IC50 = 6 µM) and blocks colchicine (Item No. 9000760) binding to tubulin.{33289} Like colchicine, TN-16 inhibits alkylation of tubulin.{33292} TN-16 induces metaphase arrest in renal cell carcinoma cells.{33291} TN-16 can be used in combination with other inhibitors to enhance the efficiency of human artificial chromosome transfer to recipient cells.{33290}  

     

    Brand:
    Cayman
    SKU:21222 -

    Out of stock

  • Tumor Necrosis Factor-α (TNF-α) is a 17 kDa polypeptide produced primarily by activated monocytes and macrophages. This polypeptide mediates many immune and inflammatory responses, including activation and differentiation of monocytes and macrophages, expression of MHC class I and II, and expression of adhesion molecules on endothelial cells.{5960,6350,5959} TNF-α is considered to be the primary mediator in many inflammatory conditions including toxic shock and sepsis.{5958,5957} Cayman’s TNF-α assay is an immunometric (i.e., sandwich) ELISA that permits TNF-α measurements within the range of 3.9-250 pg/ml, typically with a limit of detection of 3.9 pg/ml. Inter- and intra-assay CVs of less than 5% can be achieved at most concentrations. This assay allows sensitive, specific analysis of TNF-α in serum or plasma.  

     

    Brand:
    Cayman
    SKU:589201 - 480 wells

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  • Tumor Necrosis Factor-α (TNF-α) is a 17 kDa polypeptide produced primarily by activated monocytes and macrophages. This polypeptide mediates many immune and inflammatory responses, including activation and differentiation of monocytes and macrophages, expression of MHC class I and II, and expression of adhesion molecules on endothelial cells.{5960,6350,5959} TNF-α is considered to be the primary mediator in many inflammatory conditions including toxic shock and sepsis.{5958,5957} Cayman’s TNF-α assay is an immunometric (i.e., sandwich) ELISA that permits TNF-α measurements within the range of 3.9-250 pg/ml, typically with a limit of detection of 3.9 pg/ml. Inter- and intra-assay CVs of less than 5% can be achieved at most concentrations. This assay allows sensitive, specific analysis of TNF-α in serum or plasma.  

     

    Brand:
    Cayman
    SKU:589201 - 96 wells

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  • Brand:
    Cayman
    SKU:489204 - 1 ea

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  • Tumor necrosis factor-α (TNF-α) mediates many immune and inflammatory responses including activation and differentiation of monocytes and macrophages, expression of MHC class I and II, and expression of adhesion molecules on endothelial cells. Cayman’s TNF-α (mouse) ELISA Kit is an immunometric (i.e., sandwich) ELISA that permits TNF-α measurements within the range of 15.6-500 pg/ml, typically with an LLOQ of 15.6 pg/ml.  

     

    Brand:
    Cayman
    SKU:500850 - 96 wells

    Available on backorder

  • Known as cachectin, the TNF-α is a glycoprotein of 156 amino acids produced from a precursor processed by action of a metalloprotease. Isolated for the first time in 1975 by Carswell, it’s a cytokine of the innate immunity. Interleukin-1 or bacterial endotoxins stimulate the production of TNF-α by immune cells (activated macrophages, NK cells, and monocytes) and non-immune cells (keratinocytes, vascular smooth muscle cells, and granulosa lutein cells). The main function of the TNF-α is to act as an immunomodulator and as a mediator of inflammatory responses in the phenomena of host resistance to infection. It allows neutrophils and macrophages recruitment to infectious sites by stimulating the production of adhesion molecules and chemokines (chemotactic cytokines) by endothelial cells. TNF-α also acts on the hypothalamus to trigger the fever. Over-production of TNF-α has been implicated in a number of pathological conditions including cachexia, septic shock, and autoimmune disorders. [Bertin Catalog No. A05411]  

     

    Brand:
    Cayman
    SKU:23616 - 96 wells

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  • TNF-α antagonist is an exocyclic peptide that mimics the critical TNF-α recognition loop on TNF receptor I complex and, thus, prevents ligand interaction with the receptor.{28742} By blocking the TNF receptor ligand contact site, this peptide interferes with both activating receptor activator of NF-κB (RANK) and TNF-α’s recruitment and activation of osteoclasts.{28741} TNF-α antagonist has been used to block bone resorption in the study of systemic bone loss in rheumatoid arthritis and inflammatory bone destruction.{28741}  

     

    Brand:
    Cayman
    SKU:-

    Available on backorder

  • TNF-α antagonist is an exocyclic peptide that mimics the critical TNF-α recognition loop on TNF receptor I complex and, thus, prevents ligand interaction with the receptor.{28742} By blocking the TNF receptor ligand contact site, this peptide interferes with both activating receptor activator of NF-κB (RANK) and TNF-α’s recruitment and activation of osteoclasts.{28741} TNF-α antagonist has been used to block bone resorption in the study of systemic bone loss in rheumatoid arthritis and inflammatory bone destruction.{28741}  

     

    Brand:
    Cayman
    SKU:-

    Available on backorder

  • TNF-α antagonist is an exocyclic peptide that mimics the critical TNF-α recognition loop on TNF receptor I complex and, thus, prevents ligand interaction with the receptor.{28742} By blocking the TNF receptor ligand contact site, this peptide interferes with both activating receptor activator of NF-κB (RANK) and TNF-α’s recruitment and activation of osteoclasts.{28741} TNF-α antagonist has been used to block bone resorption in the study of systemic bone loss in rheumatoid arthritis and inflammatory bone destruction.{28741}  

     

    Brand:
    Cayman
    SKU:-

    Available on backorder

  • TNP is a cell-permeable inhibitor of inositol-1,4,5-trisphosphate 6-kinase 1 (IP6K1; IC50 = 0.55 µM; Ki = 0.24 µM) and IP3K (IC50 = 10.2 µM; Ki = 4.3 µM) that binds to the ATP-binding sites of both enzymes. {38146,38145} TNP reduces IP7 and IP8 levels (IC50s = ~3 and 1 µM, respectively) and inhibits insulin release in MIN6 cells.{38146} It increases intracellular calcium levels in a concentration-dependent manner in HL-60 cells, potentially due to a 2- to 3-fold accumulation of IP3, and induces degranulation in mast cells.{38147}  

     

    Brand:
    Cayman
    SKU:21189 -

    Out of stock

  • TNP is a cell-permeable inhibitor of inositol-1,4,5-trisphosphate 6-kinase 1 (IP6K1; IC50 = 0.55 µM; Ki = 0.24 µM) and IP3K (IC50 = 10.2 µM; Ki = 4.3 µM) that binds to the ATP-binding sites of both enzymes. {38146,38145} TNP reduces IP7 and IP8 levels (IC50s = ~3 and 1 µM, respectively) and inhibits insulin release in MIN6 cells.{38146} It increases intracellular calcium levels in a concentration-dependent manner in HL-60 cells, potentially due to a 2- to 3-fold accumulation of IP3, and induces degranulation in mast cells.{38147}  

     

    Brand:
    Cayman
    SKU:21189 -

    Out of stock

  • TNP is a cell-permeable inhibitor of inositol-1,4,5-trisphosphate 6-kinase 1 (IP6K1; IC50 = 0.55 µM; Ki = 0.24 µM) and IP3K (IC50 = 10.2 µM; Ki = 4.3 µM) that binds to the ATP-binding sites of both enzymes. {38146,38145} TNP reduces IP7 and IP8 levels (IC50s = ~3 and 1 µM, respectively) and inhibits insulin release in MIN6 cells.{38146} It increases intracellular calcium levels in a concentration-dependent manner in HL-60 cells, potentially due to a 2- to 3-fold accumulation of IP3, and induces degranulation in mast cells.{38147}  

     

    Brand:
    Cayman
    SKU:21189 -

    Out of stock

  • TNP is a cell-permeable inhibitor of inositol-1,4,5-trisphosphate 6-kinase 1 (IP6K1; IC50 = 0.55 µM; Ki = 0.24 µM) and IP3K (IC50 = 10.2 µM; Ki = 4.3 µM) that binds to the ATP-binding sites of both enzymes. {38146,38145} TNP reduces IP7 and IP8 levels (IC50s = ~3 and 1 µM, respectively) and inhibits insulin release in MIN6 cells.{38146} It increases intracellular calcium levels in a concentration-dependent manner in HL-60 cells, potentially due to a 2- to 3-fold accumulation of IP3, and induces degranulation in mast cells.{38147}  

     

    Brand:
    Cayman
    SKU:21189 -

    Out of stock

  • TNP-470 is a synthetic analog of fumagillin (Item No. 11332) that inhibits angiogenesis. It irreversibly inactivates methionine aminopeptidase-2 (MetAP2; IC50 = 2 µM), blocking endothelial cell proliferation in vitro and angiogenesis in vivo.{26940,26939,13713} It is without effect on MetAP1.{26940} TNP-470 has therapeutic potential in cancer and microsporidiosis.{13713,26938}  

     

    Brand:
    Cayman
    SKU:-

    Out of stock

  • TNP-470 is a synthetic analog of fumagillin (Item No. 11332) that inhibits angiogenesis. It irreversibly inactivates methionine aminopeptidase-2 (MetAP2; IC50 = 2 µM), blocking endothelial cell proliferation in vitro and angiogenesis in vivo.{26940,26939,13713} It is without effect on MetAP1.{26940} TNP-470 has therapeutic potential in cancer and microsporidiosis.{13713,26938}  

     

    Brand:
    Cayman
    SKU:-

    Out of stock

  • TNP-470 is a synthetic analog of fumagillin (Item No. 11332) that inhibits angiogenesis. It irreversibly inactivates methionine aminopeptidase-2 (MetAP2; IC50 = 2 µM), blocking endothelial cell proliferation in vitro and angiogenesis in vivo.{26940,26939,13713} It is without effect on MetAP1.{26940} TNP-470 has therapeutic potential in cancer and microsporidiosis.{13713,26938}  

     

    Brand:
    Cayman
    SKU:-

    Out of stock

  • Tobramycin is an aminoglycoside antibiotic that shows potent activity against a broad spectrum of bacteria.{22658} Particularly when used in combination with quorum sensing inhibitors, it is effective against bacteria like Pseudomonas, which form biofilms during infection.{20838} Tobramycin is commonly delivered by inhalation and has applications in cystic fibrosis and bronchiectasis.{23114,23113}  

     

    Brand:
    Cayman
    SKU:-
  • Tobramycin is an aminoglycoside antibiotic that shows potent activity against a broad spectrum of bacteria.{22658} Particularly when used in combination with quorum sensing inhibitors, it is effective against bacteria like Pseudomonas, which form biofilms during infection.{20838} Tobramycin is commonly delivered by inhalation and has applications in cystic fibrosis and bronchiectasis.{23114,23113}  

     

    Brand:
    Cayman
    SKU:-
  • Tobramycin is an aminoglycoside antibiotic that shows potent activity against a broad spectrum of bacteria.{22658} Particularly when used in combination with quorum sensing inhibitors, it is effective against bacteria like Pseudomonas, which form biofilms during infection.{20838} Tobramycin is commonly delivered by inhalation and has applications in cystic fibrosis and bronchiectasis.{23114,23113}  

     

    Brand:
    Cayman
    SKU:-
  • Toceranib is a small molecule, multi-targeted receptor tyrosine kinase inhibitor that is structurally related to sunitinib (Item No. 13159).{17826} It potently inhibits signaling through VEGFR, FGFR, PDGFR, and Kit.{17826} Moveover, toceranib blocks the autophosphorylation of both wild type and mutant forms of Kit in response to stem cell factor, resulting in cell death.{17826} It is active in vivo and is commonly used against solid tumors in dogs.{28879,28880}  

     

    Brand:
    Cayman
    SKU:-

    Available on backorder

  • Toceranib is a small molecule, multi-targeted receptor tyrosine kinase inhibitor that is structurally related to sunitinib (Item No. 13159).{17826} It potently inhibits signaling through VEGFR, FGFR, PDGFR, and Kit.{17826} Moveover, toceranib blocks the autophosphorylation of both wild type and mutant forms of Kit in response to stem cell factor, resulting in cell death.{17826} It is active in vivo and is commonly used against solid tumors in dogs.{28879,28880}  

     

    Brand:
    Cayman
    SKU:-

    Available on backorder

  • Toceranib is a small molecule, multi-targeted receptor tyrosine kinase inhibitor that is structurally related to sunitinib (Item No. 13159).{17826} It potently inhibits signaling through VEGFR, FGFR, PDGFR, and Kit.{17826} Moveover, toceranib blocks the autophosphorylation of both wild type and mutant forms of Kit in response to stem cell factor, resulting in cell death.{17826} It is active in vivo and is commonly used against solid tumors in dogs.{28879,28880}  

     

    Brand:
    Cayman
    SKU:-

    Available on backorder

  • Toceranib is a small molecule, multi-targeted receptor tyrosine kinase inhibitor that is structurally related to sunitinib (Item No. 13159).{17826} It potently inhibits signaling through VEGFR, FGFR, PDGFR, and Kit.{17826} Moveover, toceranib blocks the autophosphorylation of both wild type and mutant forms of Kit in response to stem cell factor, resulting in cell death.{17826} It is active in vivo and is commonly used against solid tumors in dogs.{28879,28880}  

     

    Brand:
    Cayman
    SKU:-

    Available on backorder

  • Todralazine (hydrochloride) is a β2-adrenergic receptor antagonist with peripheral vasodilator activity.{33946,33945} Administration of todralazine (5 µM) to pre-larval zebrafish led to hematopoietic cell expansion and protection from ionizing radiation.{33945} It inhibited histone acetylation in vitro and, long-term (4 months), but not short-term (1 month), treatment in mice (3 mg/day) impaired hepatocyte histone acetylation and liver regeneration.{33947}  

     

    Brand:
    Cayman
    SKU:20893 -

    Out of stock

  • Todralazine (hydrochloride) is a β2-adrenergic receptor antagonist with peripheral vasodilator activity.{33946,33945} Administration of todralazine (5 µM) to pre-larval zebrafish led to hematopoietic cell expansion and protection from ionizing radiation.{33945} It inhibited histone acetylation in vitro and, long-term (4 months), but not short-term (1 month), treatment in mice (3 mg/day) impaired hepatocyte histone acetylation and liver regeneration.{33947}  

     

    Brand:
    Cayman
    SKU:20893 -

    Out of stock

  • Todralazine (hydrochloride) is a β2-adrenergic receptor antagonist with peripheral vasodilator activity.{33946,33945} Administration of todralazine (5 µM) to pre-larval zebrafish led to hematopoietic cell expansion and protection from ionizing radiation.{33945} It inhibited histone acetylation in vitro and, long-term (4 months), but not short-term (1 month), treatment in mice (3 mg/day) impaired hepatocyte histone acetylation and liver regeneration.{33947}  

     

    Brand:
    Cayman
    SKU:20893 -

    Out of stock

  • Inhibition of fatty acid synthase (FASN) by the irreversible inhibitor cerulenin leads to cytotoxicity and apoptosis in human cancer cell lines.{11992} TOFA is an inhibitor of fatty acid synthesis blocking the synthesis of malonyl-CoA by acetyl-CoA carboxylase (ACC).{7659} Both cerulenin (at about 10 µg/ml) and TOFA (at about 1 µg/ml) are effective at blocking the incorporation of radiolabeled acetate into palmitate. However, TOFA reduces malonyl-CoA levels rather than elevating them, and TOFA is relatively non-toxic to various cancer cell lines. TOFA also attenuates the inhibition of feeding observed when FASN inhibitors such as cerulenin and C75 are administered to obese ob/ob mice.  

     

    Brand:
    Cayman
    SKU:10005263 - 10 mg

    Available on backorder

  • Inhibition of fatty acid synthase (FASN) by the irreversible inhibitor cerulenin leads to cytotoxicity and apoptosis in human cancer cell lines.{11992} TOFA is an inhibitor of fatty acid synthesis blocking the synthesis of malonyl-CoA by acetyl-CoA carboxylase (ACC).{7659} Both cerulenin (at about 10 µg/ml) and TOFA (at about 1 µg/ml) are effective at blocking the incorporation of radiolabeled acetate into palmitate. However, TOFA reduces malonyl-CoA levels rather than elevating them, and TOFA is relatively non-toxic to various cancer cell lines. TOFA also attenuates the inhibition of feeding observed when FASN inhibitors such as cerulenin and C75 are administered to obese ob/ob mice.  

     

    Brand:
    Cayman
    SKU:10005263 - 100 mg

    Available on backorder

  • Inhibition of fatty acid synthase (FASN) by the irreversible inhibitor cerulenin leads to cytotoxicity and apoptosis in human cancer cell lines.{11992} TOFA is an inhibitor of fatty acid synthesis blocking the synthesis of malonyl-CoA by acetyl-CoA carboxylase (ACC).{7659} Both cerulenin (at about 10 µg/ml) and TOFA (at about 1 µg/ml) are effective at blocking the incorporation of radiolabeled acetate into palmitate. However, TOFA reduces malonyl-CoA levels rather than elevating them, and TOFA is relatively non-toxic to various cancer cell lines. TOFA also attenuates the inhibition of feeding observed when FASN inhibitors such as cerulenin and C75 are administered to obese ob/ob mice.  

     

    Brand:
    Cayman
    SKU:10005263 - 5 mg

    Available on backorder

  • Inhibition of fatty acid synthase (FASN) by the irreversible inhibitor cerulenin leads to cytotoxicity and apoptosis in human cancer cell lines.{11992} TOFA is an inhibitor of fatty acid synthesis blocking the synthesis of malonyl-CoA by acetyl-CoA carboxylase (ACC).{7659} Both cerulenin (at about 10 µg/ml) and TOFA (at about 1 µg/ml) are effective at blocking the incorporation of radiolabeled acetate into palmitate. However, TOFA reduces malonyl-CoA levels rather than elevating them, and TOFA is relatively non-toxic to various cancer cell lines. TOFA also attenuates the inhibition of feeding observed when FASN inhibitors such as cerulenin and C75 are administered to obese ob/ob mice.  

     

    Brand:
    Cayman
    SKU:10005263 - 50 mg

    Available on backorder

  • Tofisopam (Item No. 22026) is an analytical reference standard categorized as a benzodiazepine.{39140} This product is intended for research and forensic applications.  

     

    Brand:
    Cayman
    SKU:22026 -

    Out of stock

  • Tofisopam (Item No. 22026) is an analytical reference standard categorized as a benzodiazepine.{39140} This product is intended for research and forensic applications.  

     

    Brand:
    Cayman
    SKU:22026 -

    Out of stock

  • Tofogliflozin is a potent inhibitor of sodium glucose cotransporter 2 (SGLT2) with Ki values of 2.9, 14.9, and 6.4 nM for human, rat, and mouse SGLT2, respectively.{38569} It is selective for SGLT2 (IC50 = 2.9 nM) over other SGLTs (IC50s = >1,500 nM for SGLT1 and 3-6). Tofogliflozin (3-10 mg/kg) reduces plasma glucose concentrations and increases renal glucose clearance in Zucker diabetic fatty rats in a dose-dependent manner. It also reduces hyperglycemia in non-fasted db/db mice and decreases postprandial hyperglycemia in GK rats, a non-obese model of type 2 diabetes with glucose intolerance.  

     

    Brand:
    Cayman
    SKU:23509 - 1 mg

    Available on backorder

  • Tofogliflozin is a potent inhibitor of sodium glucose cotransporter 2 (SGLT2) with Ki values of 2.9, 14.9, and 6.4 nM for human, rat, and mouse SGLT2, respectively.{38569} It is selective for SGLT2 (IC50 = 2.9 nM) over other SGLTs (IC50s = >1,500 nM for SGLT1 and 3-6). Tofogliflozin (3-10 mg/kg) reduces plasma glucose concentrations and increases renal glucose clearance in Zucker diabetic fatty rats in a dose-dependent manner. It also reduces hyperglycemia in non-fasted db/db mice and decreases postprandial hyperglycemia in GK rats, a non-obese model of type 2 diabetes with glucose intolerance.  

     

    Brand:
    Cayman
    SKU:23509 - 10 mg

    Available on backorder