Cayman
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17β-Estradiol-d2 is intended for use as an internal standard for the quantification of 17β-estradiol (Item Nos. ISO60155 | 10006315) by GC- or LC-MS. 17β-Estradiol is the major estrogen secreted by the premenopausal ovary. It is synthesized from testosterone primarily in the ovarian granulosa cells and placenta, but small amounts can be produced in the adrenal gland.{8343,8342} Plasma 17β-estradiol levels increase gradually between days 1-7 of the menstrual cycle followed by a sharp increase to a peak value of about 300 pg/ml on day 12, just prior to ovulation.{8458,1594}
Brand:CaymanSKU:9002846 - 1 mgAvailable on backorder
17β-Estradiol-d2 is intended for use as an internal standard for the quantification of 17β-estradiol (Item Nos. ISO60155 | 10006315) by GC- or LC-MS. 17β-Estradiol is the major estrogen secreted by the premenopausal ovary. It is synthesized from testosterone primarily in the ovarian granulosa cells and placenta, but small amounts can be produced in the adrenal gland.{8343,8342} Plasma 17β-estradiol levels increase gradually between days 1-7 of the menstrual cycle followed by a sharp increase to a peak value of about 300 pg/ml on day 12, just prior to ovulation.{8458,1594}
Brand:CaymanSKU:9002846 - 5 mgAvailable on backorder
17β-Estradiol-d2 is intended for use as an internal standard for the quantification of 17β-estradiol (Item Nos. ISO60155 | 10006315) by GC- or LC-MS. 17β-Estradiol is the major estrogen secreted by the premenopausal ovary. It is synthesized from testosterone primarily in the ovarian granulosa cells and placenta, but small amounts can be produced in the adrenal gland.{8343,8342} Plasma 17β-estradiol levels increase gradually between days 1-7 of the menstrual cycle followed by a sharp increase to a peak value of about 300 pg/ml on day 12, just prior to ovulation.{8458,1594}
Brand:CaymanSKU:9002846 - 500 µgAvailable on backorder
17β-hydroxy Exemestane is the primary active metabolite of exemestane (Item No. 15008).{37747} It is formed by metabolism of exemestane by the cytochrome P450 (CYP) isoforms CYP1A and CYP4A11.{37748} 17β-hydroxy Exemestane is an aromatase inhibitor (IC50 = 69 nM using human placental microsomes) and an androgen receptor (AR) agonist (IC50 = 39.6 nM) that is selective for AR over estrogen receptor α (ERα; IC50 = 21.2 μM).{37749,37750} It stimulates growth of AR- and ERα-positive MCF-7 (EC50 = 2.7 μM) and T47D breast cancer cells (EC50s = 0.43 and 1,500 nM for AR- and ER-mediated growth, respectively) and inhibits proliferation of testosterone-treated aromatase-overexpressing MCF-7aro cells in a concentration-dependent manner.{37750,37751} 17β-hydroxy Exemestane (20 mg/kg) inhibits increases in serum cholesterol and LDL levels and prevents decreases in bone mineral density in the lumbar vertebrae and femur, as well as femoral bending strength and compressive strength of the fifth lumbar vertebrae, in ovariectomized rats.{37747}
Brand:CaymanSKU:27989 - 1 mgAvailable on backorder
17β-hydroxy Exemestane is the primary active metabolite of exemestane (Item No. 15008).{37747} It is formed by metabolism of exemestane by the cytochrome P450 (CYP) isoforms CYP1A and CYP4A11.{37748} 17β-hydroxy Exemestane is an aromatase inhibitor (IC50 = 69 nM using human placental microsomes) and an androgen receptor (AR) agonist (IC50 = 39.6 nM) that is selective for AR over estrogen receptor α (ERα; IC50 = 21.2 μM).{37749,37750} It stimulates growth of AR- and ERα-positive MCF-7 (EC50 = 2.7 μM) and T47D breast cancer cells (EC50s = 0.43 and 1,500 nM for AR- and ER-mediated growth, respectively) and inhibits proliferation of testosterone-treated aromatase-overexpressing MCF-7aro cells in a concentration-dependent manner.{37750,37751} 17β-hydroxy Exemestane (20 mg/kg) inhibits increases in serum cholesterol and LDL levels and prevents decreases in bone mineral density in the lumbar vertebrae and femur, as well as femoral bending strength and compressive strength of the fifth lumbar vertebrae, in ovariectomized rats.{37747}
Brand:CaymanSKU:27989 - 5 mgAvailable on backorder
17β-hydroxy Wortmannin is an analog of wortmannin. It irreversibly binds phosphoinositide 3-kinase (PI3K) and potently blocks fMLP-stimulated respiratory burst in neutrophils (IC50 = 5 nM).{18125} 17β-hydroxy Wortmannin inhibits recombinant PI3K and mTOR (IC50 = 2.7 and 193 nM, respectively) and prevents the growth of LNCap prostate cancer cells (IC50 = 1.46 μM).{18123} The 17-hydroxyl group has been used to further modify this compound, e.g., by pegylation and conjugation with rapamycin.{18124,17899}
Brand:CaymanSKU:- 17β-hydroxy Wortmannin is an analog of wortmannin. It irreversibly binds phosphoinositide 3-kinase (PI3K) and potently blocks fMLP-stimulated respiratory burst in neutrophils (IC50 = 5 nM).{18125} 17β-hydroxy Wortmannin inhibits recombinant PI3K and mTOR (IC50 = 2.7 and 193 nM, respectively) and prevents the growth of LNCap prostate cancer cells (IC50 = 1.46 μM).{18123} The 17-hydroxyl group has been used to further modify this compound, e.g., by pegylation and conjugation with rapamycin.{18124,17899}
Brand:CaymanSKU:- 17β-hydroxy Wortmannin is an analog of wortmannin. It irreversibly binds phosphoinositide 3-kinase (PI3K) and potently blocks fMLP-stimulated respiratory burst in neutrophils (IC50 = 5 nM).{18125} 17β-hydroxy Wortmannin inhibits recombinant PI3K and mTOR (IC50 = 2.7 and 193 nM, respectively) and prevents the growth of LNCap prostate cancer cells (IC50 = 1.46 μM).{18123} The 17-hydroxyl group has been used to further modify this compound, e.g., by pegylation and conjugation with rapamycin.{18124,17899}
Brand:CaymanSKU:- 17β-hydroxy Wortmannin is an analog of wortmannin. It irreversibly binds phosphoinositide 3-kinase (PI3K) and potently blocks fMLP-stimulated respiratory burst in neutrophils (IC50 = 5 nM).{18125} 17β-hydroxy Wortmannin inhibits recombinant PI3K and mTOR (IC50 = 2.7 and 193 nM, respectively) and prevents the growth of LNCap prostate cancer cells (IC50 = 1.46 μM).{18123} The 17-hydroxyl group has been used to further modify this compound, e.g., by pegylation and conjugation with rapamycin.{18124,17899}
Brand:CaymanSKU:-
18-carboxy dinor Leukotriene B4 (18-carboxy dinor LTB4) is a β-oxidation metabolite of LTB4.{1032} In the liver, LTB4 is rapidly metabolized to 20-carboxy LTB4, which then undergoes β-oxidation to 18-carboxy dinor LTB4.{791}
Brand:CaymanSKU:20170 -Available on backorder
18-carboxy dinor Leukotriene B4 (18-carboxy dinor LTB4) is a β-oxidation metabolite of LTB4.{1032} In the liver, LTB4 is rapidly metabolized to 20-carboxy LTB4, which then undergoes β-oxidation to 18-carboxy dinor LTB4.{791}
Brand:CaymanSKU:20170 -Available on backorder
18-carboxy dinor Leukotriene B4 (18-carboxy dinor LTB4) is a β-oxidation metabolite of LTB4.{1032} In the liver, LTB4 is rapidly metabolized to 20-carboxy LTB4, which then undergoes β-oxidation to 18-carboxy dinor LTB4.{791}
Brand:CaymanSKU:20170 -Available on backorder
18-Deoxyherboxidiene is a bacterial metabolite that has been found in Streptomyces QN18690 and has antiangiogenic activity.{52775} It binds to the SF3b subunit of spliceosome-associated protein 130 (SAP130), SAP145, or SAP155 in HeLa cell extracts when used at 100, 1,000, and 10,000 ng and induces the accumulation of unspliced mRNA in HEK293T cells in a reporter assay. 18-Deoxyherboxidiene inhibits VEGF-induced migration of human umbilical vein endothelial cells (HUVECs) in a concentration-dependent manner and VEGF-induced HUVEC tube formation when used at a concentration of 0.3 µg/ml.
Brand:CaymanSKU:29063 - 1 mgAvailable on backorder
18-Deoxyherboxidiene is a bacterial metabolite that has been found in Streptomyces QN18690 and has antiangiogenic activity.{52775} It binds to the SF3b subunit of spliceosome-associated protein 130 (SAP130), SAP145, or SAP155 in HeLa cell extracts when used at 100, 1,000, and 10,000 ng and induces the accumulation of unspliced mRNA in HEK293T cells in a reporter assay. 18-Deoxyherboxidiene inhibits VEGF-induced migration of human umbilical vein endothelial cells (HUVECs) in a concentration-dependent manner and VEGF-induced HUVEC tube formation when used at a concentration of 0.3 µg/ml.
Brand:CaymanSKU:29063 - 500 µgAvailable on backorder
18-hydroxy-11-deoxy Corticosterone (18-OH-DOC) is a mineralocorticoid secreted by the zona fasciculata of the adrenal gland.{45039,45040} Its biosynthesis is regulated by adrenocorticotropic hormone (ACTH; Item No. 24257) as well as angiotensin II (Item No. 17150), which increases 18-OH-DOC production in isolated human adrenal glomerulosa cells.{45039,45041} 18-OH-DOC can be formed via conversion of 11-deoxy corticosterone (DOC; Item No. 22916) in human SK-MEL188 melanoma cells.{45042} 18-OH-DOC is an intermediate in the metabolism of progesterone (Item No. 15876) and can be converted to aldosterone (Item No. 15273) by the capsular portion of rat adrenal glands.{45041,45042} Continuous infusion of 18-OH-DOC (200 μg/rat per day) increases systolic blood pressure in uninephrectomized saline-drinking rats.{45040} Plasma levels of 18-OH-DOC are elevated in a db/db mouse model of type 2 diabetes.{45043}
Brand:CaymanSKU:10007851 - 1 mgAvailable on backorder
18-hydroxy-11-deoxy Corticosterone (18-OH-DOC) is a mineralocorticoid secreted by the zona fasciculata of the adrenal gland.{45039,45040} Its biosynthesis is regulated by adrenocorticotropic hormone (ACTH; Item No. 24257) as well as angiotensin II (Item No. 17150), which increases 18-OH-DOC production in isolated human adrenal glomerulosa cells.{45039,45041} 18-OH-DOC can be formed via conversion of 11-deoxy corticosterone (DOC; Item No. 22916) in human SK-MEL188 melanoma cells.{45042} 18-OH-DOC is an intermediate in the metabolism of progesterone (Item No. 15876) and can be converted to aldosterone (Item No. 15273) by the capsular portion of rat adrenal glands.{45041,45042} Continuous infusion of 18-OH-DOC (200 μg/rat per day) increases systolic blood pressure in uninephrectomized saline-drinking rats.{45040} Plasma levels of 18-OH-DOC are elevated in a db/db mouse model of type 2 diabetes.{45043}
Brand:CaymanSKU:10007851 - 500 µgAvailable on backorder
18-methyl Eicosanoic acid is a main component of the outer layer of the epicuticle of human hair and endows hydrophobicity to the outer hair surface. It is used as an additive to hair cosmetics due to its desirable conditioning effects.{19890}
Brand:CaymanSKU:11009 - 1 mgAvailable on backorder
18-methyl Eicosanoic acid is a main component of the outer layer of the epicuticle of human hair and endows hydrophobicity to the outer hair surface. It is used as an additive to hair cosmetics due to its desirable conditioning effects.{19890}
Brand:CaymanSKU:11009 - 10 mgAvailable on backorder
18-methyl Eicosanoic acid is a main component of the outer layer of the epicuticle of human hair and endows hydrophobicity to the outer hair surface. It is used as an additive to hair cosmetics due to its desirable conditioning effects.{19890}
Brand:CaymanSKU:11009 - 5 mgAvailable on backorder
18-methyl Eicosanoic acid is a main component of the outer layer of the epicuticle of human hair and endows hydrophobicity to the outer hair surface. It is used as an additive to hair cosmetics due to its desirable conditioning effects.{19890}
Brand:CaymanSKU:11009 - 500 µgAvailable on backorder
18β-Glycyrrhetinic acid is a major metabolite of glycyrrhizin (Item No. 11847), one of the main constituents of licorice. Both 18β-glycyrrhetinic acid and glycyrrhizin have been shown to exhibit anti-ulcerative, anti-inflammatory, and immunomodulatory properties. 18β-Glycyrrhetinic acid is an inhibitor of the complement pathway (IC50 = 35 μM).{21413} At 100 mg/kg/day, 18β-glycyrrhetinic acid is protective against diabetes complications by reducing lipid peroxidation and increasing antioxidant activity in diabetic rats.{21415} 18β-Glycyrrhetinic acid inhibits mammalian DNA polymerases α, γ, κ, and λ with IC50 values of 16.1, 19.3, 15.8, and 13.7 μM, respectively.{21414} At 100-200 μM, 18β-glycyrrhetinic acid suppresses LPS-induced TNF-α production and NF-κB activation in mouse macrophages.{21414}
Brand:CaymanSKU:11845 - 1 gAvailable on backorder
18β-Glycyrrhetinic acid is a major metabolite of glycyrrhizin (Item No. 11847), one of the main constituents of licorice. Both 18β-glycyrrhetinic acid and glycyrrhizin have been shown to exhibit anti-ulcerative, anti-inflammatory, and immunomodulatory properties. 18β-Glycyrrhetinic acid is an inhibitor of the complement pathway (IC50 = 35 μM).{21413} At 100 mg/kg/day, 18β-glycyrrhetinic acid is protective against diabetes complications by reducing lipid peroxidation and increasing antioxidant activity in diabetic rats.{21415} 18β-Glycyrrhetinic acid inhibits mammalian DNA polymerases α, γ, κ, and λ with IC50 values of 16.1, 19.3, 15.8, and 13.7 μM, respectively.{21414} At 100-200 μM, 18β-glycyrrhetinic acid suppresses LPS-induced TNF-α production and NF-κB activation in mouse macrophages.{21414}
Brand:CaymanSKU:11845 - 10 gAvailable on backorder
18β-Glycyrrhetinic acid is a major metabolite of glycyrrhizin (Item No. 11847), one of the main constituents of licorice. Both 18β-glycyrrhetinic acid and glycyrrhizin have been shown to exhibit anti-ulcerative, anti-inflammatory, and immunomodulatory properties. 18β-Glycyrrhetinic acid is an inhibitor of the complement pathway (IC50 = 35 μM).{21413} At 100 mg/kg/day, 18β-glycyrrhetinic acid is protective against diabetes complications by reducing lipid peroxidation and increasing antioxidant activity in diabetic rats.{21415} 18β-Glycyrrhetinic acid inhibits mammalian DNA polymerases α, γ, κ, and λ with IC50 values of 16.1, 19.3, 15.8, and 13.7 μM, respectively.{21414} At 100-200 μM, 18β-glycyrrhetinic acid suppresses LPS-induced TNF-α production and NF-κB activation in mouse macrophages.{21414}
Brand:CaymanSKU:11845 - 5 gAvailable on backorder
19-hydroxy Cholesterol is formed during metabolic oxidation of cholesterol. It has been used as an internal standard for the quantitative determination of sterols by mass spectroscopic analysis.{13295}
Brand:CaymanSKU:- 19-hydroxy Cholesterol is formed during metabolic oxidation of cholesterol. It has been used as an internal standard for the quantitative determination of sterols by mass spectroscopic analysis.{13295}
Brand:CaymanSKU:- 19-hydroxy Cholesterol is formed during metabolic oxidation of cholesterol. It has been used as an internal standard for the quantitative determination of sterols by mass spectroscopic analysis.{13295}
Brand:CaymanSKU:-
19-Norandrosterone (Item No. 22683) is an analytical reference standard categorized as an anabolic androgenic steroid.{30649} It is a major metabolite of nandrolone (Item No. 21173). This product is intended for research and forensic applications.
Brand:CaymanSKU:22683 -Out of stock
19-Norandrosterone (Item No. 22683) is an analytical reference standard categorized as an anabolic androgenic steroid.{30649} It is a major metabolite of nandrolone (Item No. 21173). This product is intended for research and forensic applications.
Brand:CaymanSKU:22683 -Out of stock
19-Norandrosterone (Item No. 22683) is an analytical reference standard categorized as an anabolic androgenic steroid.{30649} It is a major metabolite of nandrolone (Item No. 21173). This product is intended for research and forensic applications.
Brand:CaymanSKU:22683 -Out of stock
19-Noretiocholanolone (Item No. 22684) is an analytical reference standard categorized as an anabolic androgenic steroid metabolite of nandrolone (Item No. 21173).{37329} This product is intended for research and forensic applications.
Brand:CaymanSKU:22684 -Out of stock
19-Noretiocholanolone (Item No. 22684) is an analytical reference standard categorized as an anabolic androgenic steroid metabolite of nandrolone (Item No. 21173).{37329} This product is intended for research and forensic applications.
Brand:CaymanSKU:22684 -Out of stock
19-Noretiocholanolone (Item No. 22684) is an analytical reference standard categorized as an anabolic androgenic steroid metabolite of nandrolone (Item No. 21173).{37329} This product is intended for research and forensic applications.
Brand:CaymanSKU:22684 -Out of stock
19,20-Epoxycytochalasin C is a fungal metabolite originally isolated from Nemania sp. UM10M.{46279} It inhibits the growth of chloroquine-sensitive and -resistant strains of P. falciparum (IC50s = 0.07 and 0.05 ng/ml, respectively) without inducing cytotoxicity in Vero cells (IC50 = >4,760 ng/ml). 19,20-Epoxycytochalasin C is also phytotoxic, reducing growth of lettuce and bentgrass plants when used at a concentration of 1 mg/ml.
Brand:CaymanSKU:28025 - 1 mgAvailable on backorder
19,20-Epoxycytochalasin C is a fungal metabolite originally isolated from Nemania sp. UM10M.{46279} It inhibits the growth of chloroquine-sensitive and -resistant strains of P. falciparum (IC50s = 0.07 and 0.05 ng/ml, respectively) without inducing cytotoxicity in Vero cells (IC50 = >4,760 ng/ml). 19,20-Epoxycytochalasin C is also phytotoxic, reducing growth of lettuce and bentgrass plants when used at a concentration of 1 mg/ml.
Brand:CaymanSKU:28025 - 5 mgAvailable on backorder
19,20-Epoxycytochalasin D is a fungal metabolite that has been found in the endophytic fungus Nemania sp. UM10M.{46279} It is active against the chloroquine-sensitive and -resistant strains of P. falciparum (MIC = 0.4 ng/ml for both) without inducing cytotoxicity in Vero cells. It is cytotoxic to BT-549, LLC-PK11, and P388 cells (IC50s = 7.84, 8.4, and 0.16 µM, respectively) but not SK-MEL, KB, or SKOV3 cells up to a concentration of 10 µM.{46279,42800}
Brand:CaymanSKU:28050 - 1 mgAvailable on backorder
19,20-Epoxycytochalasin D is a fungal metabolite that has been found in the endophytic fungus Nemania sp. UM10M.{46279} It is active against the chloroquine-sensitive and -resistant strains of P. falciparum (MIC = 0.4 ng/ml for both) without inducing cytotoxicity in Vero cells. It is cytotoxic to BT-549, LLC-PK11, and P388 cells (IC50s = 7.84, 8.4, and 0.16 µM, respectively) but not SK-MEL, KB, or SKOV3 cells up to a concentration of 10 µM.{46279,42800}
Brand:CaymanSKU:28050 - 5 mgAvailable on backorder
19-HETE is one of the major cytochrome P450 (CYP450) metabolites of arachidonic acid that is released from the kidney in response to angiotensin II. When formed by the CYP2E1 isoform, 19-HETE is composed of 70% and 30% of the (S) and (R) stereoisomers, respectively.{15766} Both 19(S)- and 19(R)-HETE are potent vasodilators of renal preglomerular vessels.{3825} However, 19(R)-HETE at 1 µM completely blocks 20-HETE-induced vasoconstriction of renal arterioles, whereas 19(S)-HETE remains inactive.{15771,15772}
Brand:CaymanSKU:10007767 - 100 µgAvailable on backorder
19-HETE is one of the major cytochrome P450 (CYP450) metabolites of arachidonic acid that is released from the kidney in response to angiotensin II. When formed by the CYP2E1 isoform, 19-HETE is composed of 70% and 30% of the (S) and (R) stereoisomers, respectively.{15766} Both 19(S)- and 19(R)-HETE are potent vasodilators of renal preglomerular vessels.{3825} However, 19(R)-HETE at 1 µM completely blocks 20-HETE-induced vasoconstriction of renal arterioles, whereas 19(S)-HETE remains inactive.{15771,15772}
Brand:CaymanSKU:10007767 - 25 µgAvailable on backorder
19-HETE is one of the major cytochrome P450 (CYP450) metabolites of arachidonic acid that is released from the kidney in response to angiotensin II. When formed by the CYP2E1 isoform, 19-HETE is composed of 70% and 30% of the (S) and (R) stereoisomers, respectively.{15766} Both 19(S)- and 19(R)-HETE are potent vasodilators of renal preglomerular vessels.{3825} However, 19(R)-HETE at 1 µM completely blocks 20-HETE-induced vasoconstriction of renal arterioles, whereas 19(S)-HETE remains inactive.{15771,15772}
Brand:CaymanSKU:10007767 - 50 µgAvailable on backorder
Found in human seminal plasma, 19(R)-hydroxy prostaglandin A2 (19(R)-hydroxy PGA2) is presumed to be a non-enzymatic dehydration metabolite of 19(R)-hydroxy PGE2, which is also found in semen.{411}
Brand:CaymanSKU:10295 - 100 µgAvailable on backorder
Found in human seminal plasma, 19(R)-hydroxy prostaglandin A2 (19(R)-hydroxy PGA2) is presumed to be a non-enzymatic dehydration metabolite of 19(R)-hydroxy PGE2, which is also found in semen.{411}
Brand:CaymanSKU:10295 - 50 µgAvailable on backorder
Found in human seminal plasma, 19(R)-hydroxy prostaglandin A2 (19(R)-hydroxy PGA2) is presumed to be a non-enzymatic dehydration metabolite of 19(R)-hydroxy PGE2, which is also found in semen.{411}
Brand:CaymanSKU:10295 - 500 µgAvailable on backorder
Base treatment of human seminal plasma extracts converts the 19-hydroxy PGE compounds present in the sample into the corresponding PGB compounds generating strong conjugated dienone chromophores. This method has been employed to provide a rapid, UV-based analytical method for PGE quantitation. Due to its chemical stability and strong UV absorbance at 278 nm, 19(R)-hydroxy PGB2 is also used as an internal standard in extractions and HPLC to determine recovery of arachidonic acid metabolites.{2512,1544,1534}
Brand:CaymanSKU:11910 - 100 µgAvailable on backorder
Base treatment of human seminal plasma extracts converts the 19-hydroxy PGE compounds present in the sample into the corresponding PGB compounds generating strong conjugated dienone chromophores. This method has been employed to provide a rapid, UV-based analytical method for PGE quantitation. Due to its chemical stability and strong UV absorbance at 278 nm, 19(R)-hydroxy PGB2 is also used as an internal standard in extractions and HPLC to determine recovery of arachidonic acid metabolites.{2512,1544,1534}
Brand:CaymanSKU:11910 - 50 µgAvailable on backorder
Base treatment of human seminal plasma extracts converts the 19-hydroxy PGE compounds present in the sample into the corresponding PGB compounds generating strong conjugated dienone chromophores. This method has been employed to provide a rapid, UV-based analytical method for PGE quantitation. Due to its chemical stability and strong UV absorbance at 278 nm, 19(R)-hydroxy PGB2 is also used as an internal standard in extractions and HPLC to determine recovery of arachidonic acid metabolites.{2512,1544,1534}
Brand:CaymanSKU:11910 - 500 µgAvailable on backorder
19(R)-hydroxy PGE1 is the major prostaglandin found in the semen of primates, including man. It is an agonist for the EP1 and EP3 receptor subtypes, and exhibits contractile activity on smooth muscle preparations.{427,1441} It has an EC50 of 320 nM for contracting guinea pig ileum, which express EP1 receptors, and an EC50 of 80 nM for contracting chick ileum, which express EP3 receptors.{1441}
Brand:CaymanSKU:- 19(R)-hydroxy PGE1 is the major prostaglandin found in the semen of primates, including man. It is an agonist for the EP1 and EP3 receptor subtypes, and exhibits contractile activity on smooth muscle preparations.{427,1441} It has an EC50 of 320 nM for contracting guinea pig ileum, which express EP1 receptors, and an EC50 of 80 nM for contracting chick ileum, which express EP3 receptors.{1441}
Brand:CaymanSKU:- 19(R)-hydroxy PGE1 is the major prostaglandin found in the semen of primates, including man. It is an agonist for the EP1 and EP3 receptor subtypes, and exhibits contractile activity on smooth muscle preparations.{427,1441} It has an EC50 of 320 nM for contracting guinea pig ileum, which express EP1 receptors, and an EC50 of 80 nM for contracting chick ileum, which express EP3 receptors.{1441}
Brand:CaymanSKU:- 19(R)-hydroxy PGE1 is the major prostaglandin found in the semen of primates, including man. It is an agonist for the EP1 and EP3 receptor subtypes, and exhibits contractile activity on smooth muscle preparations.{427,1441} It has an EC50 of 320 nM for contracting guinea pig ileum, which express EP1 receptors, and an EC50 of 80 nM for contracting chick ileum, which express EP3 receptors.{1441}
Brand:CaymanSKU:-
19(R)-hydroxy Prostaglandin E2 (19(R)-hydroxy PGE2) is found in the semen of primates, including man.{427} It is a potent smooth muscle relaxant and a selective agonist for the EP2 receptor.{427,1441} It has an EC50 value of 200 nM for relaxing cat tracheal rings which express EP2 receptors.{1441}
Brand:CaymanSKU:- 19(R)-hydroxy Prostaglandin E2 (19(R)-hydroxy PGE2) is found in the semen of primates, including man.{427} It is a potent smooth muscle relaxant and a selective agonist for the EP2 receptor.{427,1441} It has an EC50 value of 200 nM for relaxing cat tracheal rings which express EP2 receptors.{1441}
Brand:CaymanSKU:- 19(R)-hydroxy Prostaglandin E2 (19(R)-hydroxy PGE2) is found in the semen of primates, including man.{427} It is a potent smooth muscle relaxant and a selective agonist for the EP2 receptor.{427,1441} It has an EC50 value of 200 nM for relaxing cat tracheal rings which express EP2 receptors.{1441}
Brand:CaymanSKU:- 19(R)-hydroxy Prostaglandin E2 (19(R)-hydroxy PGE2) is found in the semen of primates, including man.{427} It is a potent smooth muscle relaxant and a selective agonist for the EP2 receptor.{427,1441} It has an EC50 value of 200 nM for relaxing cat tracheal rings which express EP2 receptors.{1441}
Brand:CaymanSKU:-
19(R)-hydroxy PGF1α is an ω-1 hydroxylase metabolite of PGF1α that has been identified in the semen of humans and marsupials.{497,2390} There are no published reports on its biological activity.
Brand:CaymanSKU:- 19(R)-hydroxy PGF1α is an ω-1 hydroxylase metabolite of PGF1α that has been identified in the semen of humans and marsupials.{497,2390} There are no published reports on its biological activity.
Brand:CaymanSKU:- 19(R)-hydroxy PGF1α is an ω-1 hydroxylase metabolite of PGF1α that has been identified in the semen of humans and marsupials.{497,2390} There are no published reports on its biological activity.
Brand:CaymanSKU:-
19(R)-hydroxy PGF2α is an ω-1 hydroxylase metabolite of PGF2α found in human semen. The concentration of 19(R)-hydroxy PGF compounds (F2α and F1α together) in fresh human semen is about 20 µg/ml.{497} 19(R)-hydroxy PGF2α exhibits no activity at the FP receptor of the cat iris sphincter muscle at concentrations up to 1 µM.{1441}
Brand:CaymanSKU:-Out of stock
19(R)-hydroxy PGF2α is an ω-1 hydroxylase metabolite of PGF2α found in human semen. The concentration of 19(R)-hydroxy PGF compounds (F2α and F1α together) in fresh human semen is about 20 µg/ml.{497} 19(R)-hydroxy PGF2α exhibits no activity at the FP receptor of the cat iris sphincter muscle at concentrations up to 1 µM.{1441}
Brand:CaymanSKU:-Out of stock
19(R)-hydroxy PGF2α is an ω-1 hydroxylase metabolite of PGF2α found in human semen. The concentration of 19(R)-hydroxy PGF compounds (F2α and F1α together) in fresh human semen is about 20 µg/ml.{497} 19(R)-hydroxy PGF2α exhibits no activity at the FP receptor of the cat iris sphincter muscle at concentrations up to 1 µM.{1441}
Brand:CaymanSKU:-Out of stock
19-HETE is one of the major cytochrome P450 (CYP450) metabolites of arachidonic acid that is released from the kidney in response to angiotensin II. When formed by the CYP2E1 isoform, 19-HETE is composed of 70% and 30% of the (S) and (R) stereoisomers, respectively.{15766} Both 19(S)- and 19(R)-HETE are potent vasodilators of renal preglomerular vessels.{3825} 19(S)-HETE stimulates both renal sodium-potassium ATPase and volume absorption in the rabbit proximal straight tubule.{254,18012}
Brand:CaymanSKU:10007766 - 100 µgAvailable on backorder
19-HETE is one of the major cytochrome P450 (CYP450) metabolites of arachidonic acid that is released from the kidney in response to angiotensin II. When formed by the CYP2E1 isoform, 19-HETE is composed of 70% and 30% of the (S) and (R) stereoisomers, respectively.{15766} Both 19(S)- and 19(R)-HETE are potent vasodilators of renal preglomerular vessels.{3825} 19(S)-HETE stimulates both renal sodium-potassium ATPase and volume absorption in the rabbit proximal straight tubule.{254,18012}
Brand:CaymanSKU:10007766 - 25 µgAvailable on backorder
19-HETE is one of the major cytochrome P450 (CYP450) metabolites of arachidonic acid that is released from the kidney in response to angiotensin II. When formed by the CYP2E1 isoform, 19-HETE is composed of 70% and 30% of the (S) and (R) stereoisomers, respectively.{15766} Both 19(S)- and 19(R)-HETE are potent vasodilators of renal preglomerular vessels.{3825} 19(S)-HETE stimulates both renal sodium-potassium ATPase and volume absorption in the rabbit proximal straight tubule.{254,18012}
Brand:CaymanSKU:10007766 - 50 µgAvailable on backorder
19R(20S)-EpDPA is an oxylipin and a metabolite of docosahexaenoic acid (DHA; Item No. 90310).{46813,48940} It is formed from DHA by various cytochrome P450 (CYP) isoforms in a stereoselective manner.{48940} 19R(20S)-EpDPA (30 nM) prevents calcium-induced increases in the spontaneous beating of isolated neonatal rat cardiomyocytes (NRCMs).{18627}
Brand:CaymanSKU:28628 - 100 µgAvailable on backorder
19R(20S)-EpDPA is an oxylipin and a metabolite of docosahexaenoic acid (DHA; Item No. 90310).{46813,48940} It is formed from DHA by various cytochrome P450 (CYP) isoforms in a stereoselective manner.{48940} 19R(20S)-EpDPA (30 nM) prevents calcium-induced increases in the spontaneous beating of isolated neonatal rat cardiomyocytes (NRCMs).{18627}
Brand:CaymanSKU:28628 - 25 µgAvailable on backorder
19R(20S)-EpDPA is an oxylipin and a metabolite of docosahexaenoic acid (DHA; Item No. 90310).{46813,48940} It is formed from DHA by various cytochrome P450 (CYP) isoforms in a stereoselective manner.{48940} 19R(20S)-EpDPA (30 nM) prevents calcium-induced increases in the spontaneous beating of isolated neonatal rat cardiomyocytes (NRCMs).{18627}
Brand:CaymanSKU:28628 - 50 µgAvailable on backorder
19R(20S)-EpDPA is an oxylipin and a metabolite of docosahexaenoic acid (DHA; Item No. 90310).{46813,48940} It is formed from DHA by various cytochrome P450 (CYP) isoforms in a stereoselective manner.{48940} 19R(20S)-EpDPA (30 nM) prevents calcium-induced increases in the spontaneous beating of isolated neonatal rat cardiomyocytes (NRCMs).{18627}
Brand:CaymanSKU:28628 - 500 µgAvailable on backorder
Prostaglandin E1 (PGE1) is not a major naturally occurring PG, but is widely administered clinically for several indications including peripheral occlusive vascular disease, erectile dysfunction, and in neonatal cardiology.{22,3803} COX metabolism of the unusual fatty acid 10,13,16-docosatrienoic acid yields 1a,1b-dihomo PGE1. This rare metabolite has been recovered from incubations of whole sheep seminal vesicles, but has not been reported in humans.{11211} In ex vivo preparations of rat aorta and rat PRP, 1a,1b-dihomo PGE1 was found to be much less active than PGE1 itself.{11212}
Brand:CaymanSKU:13050 - 1 mgAvailable on backorder
Prostaglandin E1 (PGE1) is not a major naturally occurring PG, but is widely administered clinically for several indications including peripheral occlusive vascular disease, erectile dysfunction, and in neonatal cardiology.{22,3803} COX metabolism of the unusual fatty acid 10,13,16-docosatrienoic acid yields 1a,1b-dihomo PGE1. This rare metabolite has been recovered from incubations of whole sheep seminal vesicles, but has not been reported in humans.{11211} In ex vivo preparations of rat aorta and rat PRP, 1a,1b-dihomo PGE1 was found to be much less active than PGE1 itself.{11212}
Brand:CaymanSKU:13050 - 10 mgAvailable on backorder
Prostaglandin E1 (PGE1) is not a major naturally occurring PG, but is widely administered clinically for several indications including peripheral occlusive vascular disease, erectile dysfunction, and in neonatal cardiology.{22,3803} COX metabolism of the unusual fatty acid 10,13,16-docosatrienoic acid yields 1a,1b-dihomo PGE1. This rare metabolite has been recovered from incubations of whole sheep seminal vesicles, but has not been reported in humans.{11211} In ex vivo preparations of rat aorta and rat PRP, 1a,1b-dihomo PGE1 was found to be much less active than PGE1 itself.{11212}
Brand:CaymanSKU:13050 - 5 mgAvailable on backorder
1a,1b-dihomo Prostaglandin E2 (PGE2) is a rare polyunsaturated fatty acid first identified in extracts of sheep vesicular gland microsomes, known to contain COX, incubated with adrenic acid (Item No. 90300).{21156} 1a,1b-dihomo PGE2 has also been identified in conditioned media of RAW 264.7 macrophages stimulated with endotoxin and arachidonic acid (AA; Item No. 90010).{14665} This product is thought to be produced by elongation of AA to adrenic acid, which is then metabolized sequentially by COX and PGE synthase.{14665}
Brand:CaymanSKU:-Available on backorder
1a,1b-dihomo Prostaglandin E2 (PGE2) is a rare polyunsaturated fatty acid first identified in extracts of sheep vesicular gland microsomes, known to contain COX, incubated with adrenic acid (Item No. 90300).{21156} 1a,1b-dihomo PGE2 has also been identified in conditioned media of RAW 264.7 macrophages stimulated with endotoxin and arachidonic acid (AA; Item No. 90010).{14665} This product is thought to be produced by elongation of AA to adrenic acid, which is then metabolized sequentially by COX and PGE synthase.{14665}
Brand:CaymanSKU:-Available on backorder
1a,1b-dihomo Prostaglandin E2 (PGE2) is a rare polyunsaturated fatty acid first identified in extracts of sheep vesicular gland microsomes, known to contain COX, incubated with adrenic acid (Item No. 90300).{21156} 1a,1b-dihomo PGE2 has also been identified in conditioned media of RAW 264.7 macrophages stimulated with endotoxin and arachidonic acid (AA; Item No. 90010).{14665} This product is thought to be produced by elongation of AA to adrenic acid, which is then metabolized sequentially by COX and PGE synthase.{14665}
Brand:CaymanSKU:-Available on backorder
1a,1b-dihomo Prostaglandin F2α (1a,1b-dihomo PGF2α) is the theoretical product of adrenic acid in the COX pathway.{2047,1288} 1a,1b-dihomo PGF2α is primarily produced in renal medulla where adrenic acid is selectively distributed.{1288}
Brand:CaymanSKU:- 1a,1b-dihomo Prostaglandin F2α (1a,1b-dihomo PGF2α) is the theoretical product of adrenic acid in the COX pathway.{2047,1288} 1a,1b-dihomo PGF2α is primarily produced in renal medulla where adrenic acid is selectively distributed.{1288}
Brand:CaymanSKU:- 1a,1b-dihomo Prostaglandin F2α (1a,1b-dihomo PGF2α) is the theoretical product of adrenic acid in the COX pathway.{2047,1288} 1a,1b-dihomo PGF2α is primarily produced in renal medulla where adrenic acid is selectively distributed.{1288}
Brand:CaymanSKU:-
Candesartan cilexetil (Item No. 10489) is a prodrug of the potent, long-acting, and selective angiotensin II type 1 receptor (AT1) antagonist, candesartan. Clinical trials indicate a 4-16 mg/day dose of candesartan cilexetil effectively reduces diastolic blood pressure.{18425} 1H-1-ethyl Candesartan cilexetil is a process-related impurity commonly found in the bulk synthesis of candesartan cilexetil.{29093}
Brand:CaymanSKU:-Available on backorder
Candesartan cilexetil (Item No. 10489) is a prodrug of the potent, long-acting, and selective angiotensin II type 1 receptor (AT1) antagonist, candesartan. Clinical trials indicate a 4-16 mg/day dose of candesartan cilexetil effectively reduces diastolic blood pressure.{18425} 1H-1-ethyl Candesartan cilexetil is a process-related impurity commonly found in the bulk synthesis of candesartan cilexetil.{29093}
Brand:CaymanSKU:-Available on backorder
Candesartan cilexetil (Item No. 10489) is a prodrug of the potent, long-acting, and selective angiotensin II type 1 receptor (AT1) antagonist, candesartan. Clinical trials indicate a 4-16 mg/day dose of candesartan cilexetil effectively reduces diastolic blood pressure.{18425} 1H-1-ethyl Candesartan cilexetil is a process-related impurity commonly found in the bulk synthesis of candesartan cilexetil.{29093}
Brand:CaymanSKU:-Available on backorder
1β-Acetoxypolygodial is a sesquiterpenoid that has been found in T. lanceolata and has antiprotozoal activity.{53304,53305} It is active against T. cruzi amastigotes and trypomastigotes (GI50s = 57.8 and 72 µM, respectively) but not T. cruzi epimastigotes (GI50 = >100 µM).{53305}
Brand:CaymanSKU:29901 - 1 mgAvailable on backorder
1β-Acetoxypolygodial is a sesquiterpenoid that has been found in T. lanceolata and has antiprotozoal activity.{53304,53305} It is active against T. cruzi amastigotes and trypomastigotes (GI50s = 57.8 and 72 µM, respectively) but not T. cruzi epimastigotes (GI50 = >100 µM).{53305}
Brand:CaymanSKU:29901 - 5 mgAvailable on backorder
2-(1-(Thiophen-2-yl)ethylidene)hydrazinecarbothioamide is an antimicrobial agent.{58140} It is active against the Gram-negative bacteria E. coli, P. aeruginosa, and S. marcescens (MICs = 64, 100, and 70 μg/ml, respectively), the Gram-positive bacteria S. aureus, M. luteus, and B. cereus (MICs = 130, 100, and 50 μg/ml, respectively), and the fungi C. albicans, G. candidum, T. rubrum, F. oxysporum, A. flavus, and S. brevicaulis (MICs = 69-120 μg/ml). 2-(1-(Thiophen-2-yl)ethylidene)hydrazinecarbothioamide is also a precursor in the synthesis of other antimicrobial agents, as well as compounds with anticancer activity.{58140,58141}
Brand:CaymanSKU:31385 - 10 mgAvailable on backorder