Cayman
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Angiotensin II is a peptide hormone which regulates blood pressure and fluid balance, contributing to hypertension, atherosclerosis, left ventricular hypertrophy, myocardial infarction, and heart failure.{20935} Telmisartan is a nonpeptide angiotensin II receptor antagonist which selectively and insurmountably inhibits the angiotensin II AT1 receptor subtype (Ki = 3.7 nM).{20934} It also acts as a partial agonist of PPARγ, activating the receptor to 25-30% of that produced by the full agonist rosiglitazone (EC50 = 4.5 μM).{20930} Through these actions, telmisartan potently reduces blood pressure in various animal models of hypertension, diminishing cardiac hypertrophy, cardiovascular and renal risk, and glomerulosclerosis.{20932,20931,20933}
Brand:CaymanSKU:11615 - 50 mgAvailable on backorder
Angiotensin II is a peptide hormone which regulates blood pressure and fluid balance, contributing to hypertension, atherosclerosis, left ventricular hypertrophy, myocardial infarction, and heart failure.{20935} Telmisartan is a nonpeptide angiotensin II receptor antagonist which selectively and insurmountably inhibits the angiotensin II AT1 receptor subtype (Ki = 3.7 nM).{20934} It also acts as a partial agonist of PPARγ, activating the receptor to 25-30% of that produced by the full agonist rosiglitazone (EC50 = 4.5 μM).{20930} Through these actions, telmisartan potently reduces blood pressure in various animal models of hypertension, diminishing cardiac hypertrophy, cardiovascular and renal risk, and glomerulosclerosis.{20932,20931,20933}
Brand:CaymanSKU:11615 - 500 mgAvailable on backorder
Telmisartan acyl-β-D-glucuronide is a major metabolite of the angiotensin II receptor antagonist telmisartan (Item No. 11615).{48353} It does not bind human serum albumin and is cleared from rat plasma with a clearance rate of 180 ml/min/kg following intravenous administration.
Brand:CaymanSKU:28056 - 1 mgAvailable on backorder
Telmisartan-d3 is intended for use as an internal standard for the quantification of telmisartan (Item No. 11615) by GC- or LC-MS. Telmisartan is a nonpeptide angiotensin (AT) II receptor antagonist which selectively and insurmountably inhibits the AT II receptor subtype AT1 (Ki = 3.7 nM).{20934} It also acts as a partial agonist of peroxisome proliferator-activated receptor gamma (PPARγ), activating the receptor to 25-30% of that produced by the full agonist rosiglitazone (Item No. 71740; EC50 = 4.5 μM).{20930} Through these actions, telmisartan potently reduces blood pressure in various animal models of hypertension, diminishing cardiac hypertrophy, cardiovascular and renal risk, and glomerulosclerosis.{20932,20931,20933}
Brand:CaymanSKU:22568 -Out of stock
Telmisartan-d3 is intended for use as an internal standard for the quantification of telmisartan (Item No. 11615) by GC- or LC-MS. Telmisartan is a nonpeptide angiotensin (AT) II receptor antagonist which selectively and insurmountably inhibits the AT II receptor subtype AT1 (Ki = 3.7 nM).{20934} It also acts as a partial agonist of peroxisome proliferator-activated receptor gamma (PPARγ), activating the receptor to 25-30% of that produced by the full agonist rosiglitazone (Item No. 71740; EC50 = 4.5 μM).{20930} Through these actions, telmisartan potently reduces blood pressure in various animal models of hypertension, diminishing cardiac hypertrophy, cardiovascular and renal risk, and glomerulosclerosis.{20932,20931,20933}
Brand:CaymanSKU:22568 -Out of stock
Telocinobufagin is a cardiotonic steroid that has been found in skin secretions of the toad B. rubescens and has diverse biological activities.{29914,46344,46345,46346} It inhibits human kidney Na+/K+-ATPase with an IC50 value of 44.2 nM.{46345} Telocinobufagin (9.9 μg/ml) increases contraction force in isolated frog ventricle strips by 30.2%.{46344} It is cytotoxic to HL-60, HCT8, SF295, MDA-MB-435 cancer cells and human peripheral blood lymphocytes (IC50s = 0.06, 0.06, 0.03, 0.11, and 0.05 μM, respectively).{46346} Telocinobufagin is also active against E. coli and S. aureus (MICs = 64 and 128 μg/ml, respectively).{46344}
Brand:CaymanSKU:27981 - 1 mgAvailable on backorder
Telocinobufagin is a cardiotonic steroid that has been found in skin secretions of the toad B. rubescens and has diverse biological activities.{29914,46344,46345,46346} It inhibits human kidney Na+/K+-ATPase with an IC50 value of 44.2 nM.{46345} Telocinobufagin (9.9 μg/ml) increases contraction force in isolated frog ventricle strips by 30.2%.{46344} It is cytotoxic to HL-60, HCT8, SF295, MDA-MB-435 cancer cells and human peripheral blood lymphocytes (IC50s = 0.06, 0.06, 0.03, 0.11, and 0.05 μM, respectively).{46346} Telocinobufagin is also active against E. coli and S. aureus (MICs = 64 and 128 μg/ml, respectively).{46344}
Brand:CaymanSKU:27981 - 10 mgAvailable on backorder
Telocinobufagin is a cardiotonic steroid that has been found in skin secretions of the toad B. rubescens and has diverse biological activities.{29914,46344,46345,46346} It inhibits human kidney Na+/K+-ATPase with an IC50 value of 44.2 nM.{46345} Telocinobufagin (9.9 μg/ml) increases contraction force in isolated frog ventricle strips by 30.2%.{46344} It is cytotoxic to HL-60, HCT8, SF295, MDA-MB-435 cancer cells and human peripheral blood lymphocytes (IC50s = 0.06, 0.06, 0.03, 0.11, and 0.05 μM, respectively).{46346} Telocinobufagin is also active against E. coli and S. aureus (MICs = 64 and 128 μg/ml, respectively).{46344}
Brand:CaymanSKU:27981 - 25 mgAvailable on backorder
Telocinobufagin is a cardiotonic steroid that has been found in skin secretions of the toad B. rubescens and has diverse biological activities.{29914,46344,46345,46346} It inhibits human kidney Na+/K+-ATPase with an IC50 value of 44.2 nM.{46345} Telocinobufagin (9.9 μg/ml) increases contraction force in isolated frog ventricle strips by 30.2%.{46344} It is cytotoxic to HL-60, HCT8, SF295, MDA-MB-435 cancer cells and human peripheral blood lymphocytes (IC50s = 0.06, 0.06, 0.03, 0.11, and 0.05 μM, respectively).{46346} Telocinobufagin is also active against E. coli and S. aureus (MICs = 64 and 128 μg/ml, respectively).{46344}
Brand:CaymanSKU:27981 - 5 mgAvailable on backorder
Telomycin is a macrocyclic peptide lactone antibiotic originally isolated from Streptomyces.{42779} It is active against Gram-positive bacteria, including S. aureus, methicillin-resistant S. aureus (MRSA), and E. faecium (MICs = 4, 2, and 16 µg/ml, respectively).{42780} Telomycin eradicates B. anserina spirochetosis infection in chicks.{42781}
Brand:CaymanSKU:28137 - 2.5 mgAvailable on backorder
Telomycin is a macrocyclic peptide lactone antibiotic originally isolated from Streptomyces.{42779} It is active against Gram-positive bacteria, including S. aureus, methicillin-resistant S. aureus (MRSA), and E. faecium (MICs = 4, 2, and 16 µg/ml, respectively).{42780} Telomycin eradicates B. anserina spirochetosis infection in chicks.{42781}
Brand:CaymanSKU:28137 - 500 µgAvailable on backorder
Telotristat is a tryptophan hydroxylase 1 (TPH1) inhibitor (IC50 = 16 nM).{43269} Dietary administration of telotristat to pregnant and lactating mice decreases serotonin (5-HT; Item No. 14332) levels in maternal serum and decreases the femoral bone volume to tissue volume ratio, trabecular number and thickness, and cortical tissue mineral density, as well as serum calcium levels, in pups.{52207}
Brand:CaymanSKU:29424 - 10 mgAvailable on backorder
Telotristat is a tryptophan hydroxylase 1 (TPH1) inhibitor (IC50 = 16 nM).{43269} Dietary administration of telotristat to pregnant and lactating mice decreases serotonin (5-HT; Item No. 14332) levels in maternal serum and decreases the femoral bone volume to tissue volume ratio, trabecular number and thickness, and cortical tissue mineral density, as well as serum calcium levels, in pups.{52207}
Brand:CaymanSKU:29424 - 5 mgAvailable on backorder
Telotristat etiprate is a prodrug form of telotristat, which is an inhibitor of tryptophan hydroxylase 1 (TPH1).{43269} Telotristat etiprate (15-300 mg/kg) reduces levels of serotonin (5-HT; Item No. 14332) in mouse jejunum and blood but not brain.{43270} It inhibits increases in IL-1β and IL-6 levels, histological damage in the colon, and weight loss in a mouse model of trinitrobenzene sulfonic acid-induced colitis when administered at a dose of 200 mg/kg. In mice infected with the nematode T. muris, telotristat etiprate (300 mg/kg per day) reduces colonic levels of myeloperoxidase (MPO), IL-1β, and IL-17, as well as worm burden.{43271} Formulations containing telotristat etiprate have been used in the treatment of diarrhea associated with carcinoid syndrome.
Brand:CaymanSKU:25342 - 10 mgAvailable on backorder
Telotristat etiprate is a prodrug form of telotristat, which is an inhibitor of tryptophan hydroxylase 1 (TPH1).{43269} Telotristat etiprate (15-300 mg/kg) reduces levels of serotonin (5-HT; Item No. 14332) in mouse jejunum and blood but not brain.{43270} It inhibits increases in IL-1β and IL-6 levels, histological damage in the colon, and weight loss in a mouse model of trinitrobenzene sulfonic acid-induced colitis when administered at a dose of 200 mg/kg. In mice infected with the nematode T. muris, telotristat etiprate (300 mg/kg per day) reduces colonic levels of myeloperoxidase (MPO), IL-1β, and IL-17, as well as worm burden.{43271} Formulations containing telotristat etiprate have been used in the treatment of diarrhea associated with carcinoid syndrome.
Brand:CaymanSKU:25342 - 25 mgAvailable on backorder
Telotristat etiprate is a prodrug form of telotristat, which is an inhibitor of tryptophan hydroxylase 1 (TPH1).{43269} Telotristat etiprate (15-300 mg/kg) reduces levels of serotonin (5-HT; Item No. 14332) in mouse jejunum and blood but not brain.{43270} It inhibits increases in IL-1β and IL-6 levels, histological damage in the colon, and weight loss in a mouse model of trinitrobenzene sulfonic acid-induced colitis when administered at a dose of 200 mg/kg. In mice infected with the nematode T. muris, telotristat etiprate (300 mg/kg per day) reduces colonic levels of myeloperoxidase (MPO), IL-1β, and IL-17, as well as worm burden.{43271} Formulations containing telotristat etiprate have been used in the treatment of diarrhea associated with carcinoid syndrome.
Brand:CaymanSKU:25342 - 5 mgAvailable on backorder
Telotristat etiprate is a prodrug form of telotristat, which is an inhibitor of tryptophan hydroxylase 1 (TPH1).{43269} Telotristat etiprate (15-300 mg/kg) reduces levels of serotonin (5-HT; Item No. 14332) in mouse jejunum and blood but not brain.{43270} It inhibits increases in IL-1β and IL-6 levels, histological damage in the colon, and weight loss in a mouse model of trinitrobenzene sulfonic acid-induced colitis when administered at a dose of 200 mg/kg. In mice infected with the nematode T. muris, telotristat etiprate (300 mg/kg per day) reduces colonic levels of myeloperoxidase (MPO), IL-1β, and IL-17, as well as worm burden.{43271} Formulations containing telotristat etiprate have been used in the treatment of diarrhea associated with carcinoid syndrome.
Brand:CaymanSKU:25342 - 50 mgAvailable on backorder
Temafloxacin is a fluoroquinolone antibiotic that acts as a DNA topoisomerase inhibitor.{28547} It has broad antimicrobial activity against gram-positive and gram-negative bacteria, such as S. pneumoniae, M. hominis, and anaerobic bacteria, including B. fragilis.{28547}
Brand:CaymanSKU:-Available on backorder
Temafloxacin is a fluoroquinolone antibiotic that acts as a DNA topoisomerase inhibitor.{28547} It has broad antimicrobial activity against gram-positive and gram-negative bacteria, such as S. pneumoniae, M. hominis, and anaerobic bacteria, including B. fragilis.{28547}
Brand:CaymanSKU:-Available on backorder
Temafloxacin is a fluoroquinolone antibiotic that acts as a DNA topoisomerase inhibitor.{28547} It has broad antimicrobial activity against gram-positive and gram-negative bacteria, such as S. pneumoniae, M. hominis, and anaerobic bacteria, including B. fragilis.{28547}
Brand:CaymanSKU:-Available on backorder
Temafloxacin is a fluoroquinolone antibiotic that acts as a DNA topoisomerase inhibitor.{28547} It has broad antimicrobial activity against gram-positive and gram-negative bacteria, such as S. pneumoniae, M. hominis, and anaerobic bacteria, including B. fragilis.{28547}
Brand:CaymanSKU:-Available on backorder
Angiotensin-converting enzyme (ACE) converts angiotensin I to angiotensin II, a peptide hormone that impacts vascular smooth muscle tone and renal salt exchange, driving hypertension. Temocapril is a prodrug of the ACE inhibitor, temocaprilat (IC50 = 3.6 and 7.6 nM in isolated rat lung and aorta, respectively).{29582} Upon oral administration it is rapidly deesterified to the active form, which remains long acting until excreted in bile and urine.{29582} In clinical trials, it has been used to reduce blood pressure, improve endothelial dysfunction, and prevent vascular remodeling, as well as improve insulin sensitivity and renal function in certain hypertensive or diabetic conditions.{29582}
Brand:CaymanSKU:-Available on backorder
Angiotensin-converting enzyme (ACE) converts angiotensin I to angiotensin II, a peptide hormone that impacts vascular smooth muscle tone and renal salt exchange, driving hypertension. Temocapril is a prodrug of the ACE inhibitor, temocaprilat (IC50 = 3.6 and 7.6 nM in isolated rat lung and aorta, respectively).{29582} Upon oral administration it is rapidly deesterified to the active form, which remains long acting until excreted in bile and urine.{29582} In clinical trials, it has been used to reduce blood pressure, improve endothelial dysfunction, and prevent vascular remodeling, as well as improve insulin sensitivity and renal function in certain hypertensive or diabetic conditions.{29582}
Brand:CaymanSKU:-Available on backorder
Angiotensin-converting enzyme (ACE) converts angiotensin I to angiotensin II, a peptide hormone that impacts vascular smooth muscle tone and renal salt exchange, driving hypertension. Temocapril is a prodrug of the ACE inhibitor, temocaprilat (IC50 = 3.6 and 7.6 nM in isolated rat lung and aorta, respectively).{29582} Upon oral administration it is rapidly deesterified to the active form, which remains long acting until excreted in bile and urine.{29582} In clinical trials, it has been used to reduce blood pressure, improve endothelial dysfunction, and prevent vascular remodeling, as well as improve insulin sensitivity and renal function in certain hypertensive or diabetic conditions.{29582}
Brand:CaymanSKU:-Available on backorder
Angiotensin-converting enzyme (ACE) converts angiotensin I to angiotensin II, a peptide hormone that impacts vascular smooth muscle tone and renal salt exchange, driving hypertension. Temocapril is a prodrug of the ACE inhibitor, temocaprilat (IC50 = 3.6 and 7.6 nM in isolated rat lung and aorta, respectively).{29582} Upon oral administration it is rapidly deesterified to the active form, which remains long acting until excreted in bile and urine.{29582} In clinical trials, it has been used to reduce blood pressure, improve endothelial dysfunction, and prevent vascular remodeling, as well as improve insulin sensitivity and renal function in certain hypertensive or diabetic conditions.{29582}
Brand:CaymanSKU:-Available on backorder
Temocaprilat is an inhibitor of angiotensin-converting enzyme (ACE; IC50 = 3.6 nM for rabbit lung ACE).{49120} It inhibits contraction of isolated rat aorta induced by angiotensin I (Item No. 24737) with an IC50 value of 7.6 nM. Temocaprilat (1-30 μg/kg, i.v.) inhibits angiotensin I-induced pressor responses in anesthetized rats in a dose-dependent manner.
Brand:CaymanSKU:22169 -Out of stock
Temocaprilat is an inhibitor of angiotensin-converting enzyme (ACE; IC50 = 3.6 nM for rabbit lung ACE).{49120} It inhibits contraction of isolated rat aorta induced by angiotensin I (Item No. 24737) with an IC50 value of 7.6 nM. Temocaprilat (1-30 μg/kg, i.v.) inhibits angiotensin I-induced pressor responses in anesthetized rats in a dose-dependent manner.
Brand:CaymanSKU:22169 -Out of stock
Temocaprilat is an inhibitor of angiotensin-converting enzyme (ACE; IC50 = 3.6 nM for rabbit lung ACE).{49120} It inhibits contraction of isolated rat aorta induced by angiotensin I (Item No. 24737) with an IC50 value of 7.6 nM. Temocaprilat (1-30 μg/kg, i.v.) inhibits angiotensin I-induced pressor responses in anesthetized rats in a dose-dependent manner.
Brand:CaymanSKU:22169 -Out of stock
Temoporfin is a synthetic chlorin with light-activated actions. When administered systemically, temoporfin accumulates in tumor cells.{28585,28587} When stimulated with light (650-652 nm) in the presence of oxygen, reactive oxygen species are generated, leading to necrosis within the tumor.{28585,28587} Different approaches to using photodynamic therapy with temoporfin in palliative care are currently of interest.{28586,28588}
Brand:CaymanSKU:-Available on backorder
Temoporfin is a synthetic chlorin with light-activated actions. When administered systemically, temoporfin accumulates in tumor cells.{28585,28587} When stimulated with light (650-652 nm) in the presence of oxygen, reactive oxygen species are generated, leading to necrosis within the tumor.{28585,28587} Different approaches to using photodynamic therapy with temoporfin in palliative care are currently of interest.{28586,28588}
Brand:CaymanSKU:-Available on backorder
Temoporfin is a synthetic chlorin with light-activated actions. When administered systemically, temoporfin accumulates in tumor cells.{28585,28587} When stimulated with light (650-652 nm) in the presence of oxygen, reactive oxygen species are generated, leading to necrosis within the tumor.{28585,28587} Different approaches to using photodynamic therapy with temoporfin in palliative care are currently of interest.{28586,28588}
Brand:CaymanSKU:-Available on backorder
Temoporfin is a synthetic chlorin with light-activated actions. When administered systemically, temoporfin accumulates in tumor cells.{28585,28587} When stimulated with light (650-652 nm) in the presence of oxygen, reactive oxygen species are generated, leading to necrosis within the tumor.{28585,28587} Different approaches to using photodynamic therapy with temoporfin in palliative care are currently of interest.{28586,28588}
Brand:CaymanSKU:-Available on backorder
Temozolomide (TMZ) is an imidazotetrazine that is converted to a compound capable of alkylating DNA, thus interfering with DNA replication and leading to cytotoxicity in proliferating cells.{21297} TMZ is rapidly and completely absorbed from the gastrointestinal tract after oral administration and readily crosses the blood-brain barrier.{21297} It is effective in a variety of types of cancer, including aggressive brain cancers.{21297,21296,20678}
Brand:CaymanSKU:- Temozolomide (TMZ) is an imidazotetrazine that is converted to a compound capable of alkylating DNA, thus interfering with DNA replication and leading to cytotoxicity in proliferating cells.{21297} TMZ is rapidly and completely absorbed from the gastrointestinal tract after oral administration and readily crosses the blood-brain barrier.{21297} It is effective in a variety of types of cancer, including aggressive brain cancers.{21297,21296,20678}
Brand:CaymanSKU:- Temozolomide (TMZ) is an imidazotetrazine that is converted to a compound capable of alkylating DNA, thus interfering with DNA replication and leading to cytotoxicity in proliferating cells.{21297} TMZ is rapidly and completely absorbed from the gastrointestinal tract after oral administration and readily crosses the blood-brain barrier.{21297} It is effective in a variety of types of cancer, including aggressive brain cancers.{21297,21296,20678}
Brand:CaymanSKU:- Temozolomide (TMZ) is an imidazotetrazine that is converted to a compound capable of alkylating DNA, thus interfering with DNA replication and leading to cytotoxicity in proliferating cells.{21297} TMZ is rapidly and completely absorbed from the gastrointestinal tract after oral administration and readily crosses the blood-brain barrier.{21297} It is effective in a variety of types of cancer, including aggressive brain cancers.{21297,21296,20678}
Brand:CaymanSKU:-
Temozolomide-d3 (TMZ-d3) contains three deuterium atoms located on the methyl group. It is intended for use as an internal standard for the quantification of temozolomide (Item No. 14163) by GC- or LC-MS. TMZ is an imidazotetrazine that is converted to a compound capable of alkylating DNA, thus interfering with DNA replication and leading to cytotoxicity in proliferating cells.{21297} TMZ is rapidly and completely absorbed from the gastrointestinal tract after oral administration and readily crosses the blood-brain barrier.{21297} Formulations containing TMZ are effective in a variety of types of cancer, including aggressive brain cancers.{21297,21296,20678}
Brand:CaymanSKU:22372 -Out of stock
Temozolomide-d3 (TMZ-d3) contains three deuterium atoms located on the methyl group. It is intended for use as an internal standard for the quantification of temozolomide (Item No. 14163) by GC- or LC-MS. TMZ is an imidazotetrazine that is converted to a compound capable of alkylating DNA, thus interfering with DNA replication and leading to cytotoxicity in proliferating cells.{21297} TMZ is rapidly and completely absorbed from the gastrointestinal tract after oral administration and readily crosses the blood-brain barrier.{21297} Formulations containing TMZ are effective in a variety of types of cancer, including aggressive brain cancers.{21297,21296,20678}
Brand:CaymanSKU:22372 -Out of stock
Temozolomide-d3 (TMZ-d3) contains three deuterium atoms located on the methyl group. It is intended for use as an internal standard for the quantification of temozolomide (Item No. 14163) by GC- or LC-MS. TMZ is an imidazotetrazine that is converted to a compound capable of alkylating DNA, thus interfering with DNA replication and leading to cytotoxicity in proliferating cells.{21297} TMZ is rapidly and completely absorbed from the gastrointestinal tract after oral administration and readily crosses the blood-brain barrier.{21297} Formulations containing TMZ are effective in a variety of types of cancer, including aggressive brain cancers.{21297,21296,20678}
Brand:CaymanSKU:22372 -Out of stock
TEMPOL is a piperidine nitroxide and spin label with superoxide dismutase (SOD) mimetic activity.{31349,24288,48335} It inhibits lipid peroxidation in rat liver microsomes with 50% inhibition of microsomal lipid peroxidation (IP50) values of 117, 61, and 381 μM for peroxidation induced by iron plus NADPH, iron plus ascorbate, and t-butylhydroperoxide, respectively.{31349} TEMPOL (1 mM) inhibits production of superoxide anions by 92% via a xanthine-xanthine oxidase reaction in vitro.{24288} It reduces mean arterial pressure and heart rate in spontaneously hypertensive rats (ED50s = 70 and 63 μmol/kg, respectively) when administered intravenously. TEMPOL is a cell-permeable spin label that has been used to quantify intracellular oxygen in various cell types by electron spin resonance (ESR) spectroscopy.{48335}
Brand:CaymanSKU:27051 - 100 gAvailable on backorder
TEMPOL is a piperidine nitroxide and spin label with superoxide dismutase (SOD) mimetic activity.{31349,24288,48335} It inhibits lipid peroxidation in rat liver microsomes with 50% inhibition of microsomal lipid peroxidation (IP50) values of 117, 61, and 381 μM for peroxidation induced by iron plus NADPH, iron plus ascorbate, and t-butylhydroperoxide, respectively.{31349} TEMPOL (1 mM) inhibits production of superoxide anions by 92% via a xanthine-xanthine oxidase reaction in vitro.{24288} It reduces mean arterial pressure and heart rate in spontaneously hypertensive rats (ED50s = 70 and 63 μmol/kg, respectively) when administered intravenously. TEMPOL is a cell-permeable spin label that has been used to quantify intracellular oxygen in various cell types by electron spin resonance (ESR) spectroscopy.{48335}
Brand:CaymanSKU:27051 - 25 gAvailable on backorder
TEMPOL is a piperidine nitroxide and spin label with superoxide dismutase (SOD) mimetic activity.{31349,24288,48335} It inhibits lipid peroxidation in rat liver microsomes with 50% inhibition of microsomal lipid peroxidation (IP50) values of 117, 61, and 381 μM for peroxidation induced by iron plus NADPH, iron plus ascorbate, and t-butylhydroperoxide, respectively.{31349} TEMPOL (1 mM) inhibits production of superoxide anions by 92% via a xanthine-xanthine oxidase reaction in vitro.{24288} It reduces mean arterial pressure and heart rate in spontaneously hypertensive rats (ED50s = 70 and 63 μmol/kg, respectively) when administered intravenously. TEMPOL is a cell-permeable spin label that has been used to quantify intracellular oxygen in various cell types by electron spin resonance (ESR) spectroscopy.{48335}
Brand:CaymanSKU:27051 - 250 gAvailable on backorder
TEMPOL is a piperidine nitroxide and spin label with superoxide dismutase (SOD) mimetic activity.{31349,24288,48335} It inhibits lipid peroxidation in rat liver microsomes with 50% inhibition of microsomal lipid peroxidation (IP50) values of 117, 61, and 381 μM for peroxidation induced by iron plus NADPH, iron plus ascorbate, and t-butylhydroperoxide, respectively.{31349} TEMPOL (1 mM) inhibits production of superoxide anions by 92% via a xanthine-xanthine oxidase reaction in vitro.{24288} It reduces mean arterial pressure and heart rate in spontaneously hypertensive rats (ED50s = 70 and 63 μmol/kg, respectively) when administered intravenously. TEMPOL is a cell-permeable spin label that has been used to quantify intracellular oxygen in various cell types by electron spin resonance (ESR) spectroscopy.{48335}
Brand:CaymanSKU:27051 - 50 gAvailable on backorder
2,2,6,6-Tetramethylpiperidin-1-oxyl (TEMPO) is a stable radical that will react with reactive oxygen species (ROS).{15948} This conversion, followed by ESR, provides an indirect way to monitor ROS production in biological systems. TEMPONE is the 4-oxo derivative of TEMPO. In addition to possible uses as a spin trap, this nitroxyl radical can be used in hydrogen transfer experiments and as a polarizing agent in dynamic nuclear polarization NMR spectroscopy.{24287,24289} TEMPONE and other nitroxyl radicals have also been shown to reduce mean arterial pressure in spontaneously hypertensive rats when administered intravenously.{24288}
Brand:CaymanSKU:- 2,2,6,6-Tetramethylpiperidin-1-oxyl (TEMPO) is a stable radical that will react with reactive oxygen species (ROS).{15948} This conversion, followed by ESR, provides an indirect way to monitor ROS production in biological systems. TEMPONE is the 4-oxo derivative of TEMPO. In addition to possible uses as a spin trap, this nitroxyl radical can be used in hydrogen transfer experiments and as a polarizing agent in dynamic nuclear polarization NMR spectroscopy.{24287,24289} TEMPONE and other nitroxyl radicals have also been shown to reduce mean arterial pressure in spontaneously hypertensive rats when administered intravenously.{24288}
Brand:CaymanSKU:- 2,2,6,6-Tetramethylpiperidin-1-oxyl (TEMPO) is a stable radical that will react with reactive oxygen species (ROS).{15948} This conversion, followed by ESR, provides an indirect way to monitor ROS production in biological systems. TEMPONE is the 4-oxo derivative of TEMPO. In addition to possible uses as a spin trap, this nitroxyl radical can be used in hydrogen transfer experiments and as a polarizing agent in dynamic nuclear polarization NMR spectroscopy.{24287,24289} TEMPONE and other nitroxyl radicals have also been shown to reduce mean arterial pressure in spontaneously hypertensive rats when administered intravenously.{24288}
Brand:CaymanSKU:- 2,2,6,6-Tetramethylpiperidin-1-oxyl (TEMPO) is a stable radical that will react with reactive oxygen species (ROS).{15948} This conversion, followed by ESR, provides an indirect way to monitor ROS production in biological systems. TEMPONE is the 4-oxo derivative of TEMPO. In addition to possible uses as a spin trap, this nitroxyl radical can be used in hydrogen transfer experiments and as a polarizing agent in dynamic nuclear polarization NMR spectroscopy.{24287,24289} TEMPONE and other nitroxyl radicals have also been shown to reduce mean arterial pressure in spontaneously hypertensive rats when administered intravenously.{24288}
Brand:CaymanSKU:-
Rapamycin (Item No. 13346) is an immunosuppressant that specifically interacts with the cytosolic FK-binding protein 12 to form a complex which inhibits the mammalian target of rapamycin (mTOR) pathway by directly binding to mTOR Complex 1. Temsirolimus is a dihydroxymethyl propionic acid ester of rapamycin with improved solubility that specifically inhibits mTOR signaling with a potency similar to that of rapamycin.{22731} Treatment with temsirolimus leads to cell cycle arrest in the G1 phase and also inhibition of tumor angiogenesis by reducing synthesis of VEGF.{22733,22730} Temsirolimus demonstrates cytostatic activity in several xenograft models of human tumors in nude mice, including glioblastomas, prostate carcinoma, pancreatic, liver, and breast cancers, and medulloblastoma.{22733,22732,22730,22731}
Brand:CaymanSKU:11590 - 1 mgAvailable on backorder
Rapamycin (Item No. 13346) is an immunosuppressant that specifically interacts with the cytosolic FK-binding protein 12 to form a complex which inhibits the mammalian target of rapamycin (mTOR) pathway by directly binding to mTOR Complex 1. Temsirolimus is a dihydroxymethyl propionic acid ester of rapamycin with improved solubility that specifically inhibits mTOR signaling with a potency similar to that of rapamycin.{22731} Treatment with temsirolimus leads to cell cycle arrest in the G1 phase and also inhibition of tumor angiogenesis by reducing synthesis of VEGF.{22733,22730} Temsirolimus demonstrates cytostatic activity in several xenograft models of human tumors in nude mice, including glioblastomas, prostate carcinoma, pancreatic, liver, and breast cancers, and medulloblastoma.{22733,22732,22730,22731}
Brand:CaymanSKU:11590 - 10 mgAvailable on backorder
Rapamycin (Item No. 13346) is an immunosuppressant that specifically interacts with the cytosolic FK-binding protein 12 to form a complex which inhibits the mammalian target of rapamycin (mTOR) pathway by directly binding to mTOR Complex 1. Temsirolimus is a dihydroxymethyl propionic acid ester of rapamycin with improved solubility that specifically inhibits mTOR signaling with a potency similar to that of rapamycin.{22731} Treatment with temsirolimus leads to cell cycle arrest in the G1 phase and also inhibition of tumor angiogenesis by reducing synthesis of VEGF.{22733,22730} Temsirolimus demonstrates cytostatic activity in several xenograft models of human tumors in nude mice, including glioblastomas, prostate carcinoma, pancreatic, liver, and breast cancers, and medulloblastoma.{22733,22732,22730,22731}
Brand:CaymanSKU:11590 - 25 mgAvailable on backorder
Rapamycin (Item No. 13346) is an immunosuppressant that specifically interacts with the cytosolic FK-binding protein 12 to form a complex which inhibits the mammalian target of rapamycin (mTOR) pathway by directly binding to mTOR Complex 1. Temsirolimus is a dihydroxymethyl propionic acid ester of rapamycin with improved solubility that specifically inhibits mTOR signaling with a potency similar to that of rapamycin.{22731} Treatment with temsirolimus leads to cell cycle arrest in the G1 phase and also inhibition of tumor angiogenesis by reducing synthesis of VEGF.{22733,22730} Temsirolimus demonstrates cytostatic activity in several xenograft models of human tumors in nude mice, including glioblastomas, prostate carcinoma, pancreatic, liver, and breast cancers, and medulloblastoma.{22733,22732,22730,22731}
Brand:CaymanSKU:11590 - 5 mgAvailable on backorder
Tenatoprazole is a proton pump inhibitor, blocking hog gastric H+/K+-ATPase activity with an IC50 value of 6.2 µM.{32337} It is orally bioavailable, blocking induced gastric acid secretion and ulcer formation in rats and humans.{32337,32335,32336} Tenatoprazole has a prolonged plasma half-life resulting in persistent effectiveness after withdrawal.{32336}
Brand:CaymanSKU:-Available on backorder
Tenatoprazole is a proton pump inhibitor, blocking hog gastric H+/K+-ATPase activity with an IC50 value of 6.2 µM.{32337} It is orally bioavailable, blocking induced gastric acid secretion and ulcer formation in rats and humans.{32337,32335,32336} Tenatoprazole has a prolonged plasma half-life resulting in persistent effectiveness after withdrawal.{32336}
Brand:CaymanSKU:-Available on backorder
Tenatoprazole is a proton pump inhibitor, blocking hog gastric H+/K+-ATPase activity with an IC50 value of 6.2 µM.{32337} It is orally bioavailable, blocking induced gastric acid secretion and ulcer formation in rats and humans.{32337,32335,32336} Tenatoprazole has a prolonged plasma half-life resulting in persistent effectiveness after withdrawal.{32336}
Brand:CaymanSKU:-Available on backorder
Tenatoprazole is a proton pump inhibitor, blocking hog gastric H+/K+-ATPase activity with an IC50 value of 6.2 µM.{32337} It is orally bioavailable, blocking induced gastric acid secretion and ulcer formation in rats and humans.{32337,32335,32336} Tenatoprazole has a prolonged plasma half-life resulting in persistent effectiveness after withdrawal.{32336}
Brand:CaymanSKU:-Available on backorder
Teneligliptin is a dipeptidyl peptidase 4 (DPP-4) inhibitor (IC50s = 0.37 and 0.29 nM for the human and rat enzymes, respectively).{46687} It is selective for DPP-4 over DPP-8 and DPP-9 (IC50s = 260 and 540 nM, respectively, for the human enzymes). Teneligliptin (0.03-1 mg/kg) inhibits increases in plasma glucose levels in an oral glucose tolerance test in Zucker fatty rats. It reduces body weight, inhibits hepatic steatosis, and decreases plasma insulin levels in a mouse model of high-fat diet-induced obesity when administered at doses of 30 and 60 mg/kg.{46688} Teneligliptin scavenges hydroxyl radicals in a cell-free assay (IC50 = 0.315 mM) and decreases urinary levels of 8-hydroxy-2′-deoxyguanosine (8-OHdG; Item No. 89320), a marker of oxidative stress, in a DPP-4-deficient rat model of diabetes induced by streptozotocin (STZ; Item No. 13104) when administered at a dose of 10 mg/kg per day.{46689}
Brand:CaymanSKU:29515 - 100 mgAvailable on backorder
Teneligliptin is a dipeptidyl peptidase 4 (DPP-4) inhibitor (IC50s = 0.37 and 0.29 nM for the human and rat enzymes, respectively).{46687} It is selective for DPP-4 over DPP-8 and DPP-9 (IC50s = 260 and 540 nM, respectively, for the human enzymes). Teneligliptin (0.03-1 mg/kg) inhibits increases in plasma glucose levels in an oral glucose tolerance test in Zucker fatty rats. It reduces body weight, inhibits hepatic steatosis, and decreases plasma insulin levels in a mouse model of high-fat diet-induced obesity when administered at doses of 30 and 60 mg/kg.{46688} Teneligliptin scavenges hydroxyl radicals in a cell-free assay (IC50 = 0.315 mM) and decreases urinary levels of 8-hydroxy-2′-deoxyguanosine (8-OHdG; Item No. 89320), a marker of oxidative stress, in a DPP-4-deficient rat model of diabetes induced by streptozotocin (STZ; Item No. 13104) when administered at a dose of 10 mg/kg per day.{46689}
Brand:CaymanSKU:29515 - 250 mgAvailable on backorder
Teneligliptin is a dipeptidyl peptidase 4 (DPP-4) inhibitor (IC50s = 0.37 and 0.29 nM for the human and rat enzymes, respectively).{46687} It is selective for DPP-4 over DPP-8 and DPP-9 (IC50s = 260 and 540 nM, respectively, for the human enzymes). Teneligliptin (0.03-1 mg/kg) inhibits increases in plasma glucose levels in an oral glucose tolerance test in Zucker fatty rats. It reduces body weight, inhibits hepatic steatosis, and decreases plasma insulin levels in a mouse model of high-fat diet-induced obesity when administered at doses of 30 and 60 mg/kg.{46688} Teneligliptin scavenges hydroxyl radicals in a cell-free assay (IC50 = 0.315 mM) and decreases urinary levels of 8-hydroxy-2′-deoxyguanosine (8-OHdG; Item No. 89320), a marker of oxidative stress, in a DPP-4-deficient rat model of diabetes induced by streptozotocin (STZ; Item No. 13104) when administered at a dose of 10 mg/kg per day.{46689}
Brand:CaymanSKU:29515 - 50 mgAvailable on backorder
Teneligliptin is a dipeptidyl peptidase 4 (DPP-4) inhibitor (IC50s = 0.37 and 0.29 nM for the human and rat enzymes, respectively).{46687} It is selective for DPP-4 over DPP-8 and DPP-9 (IC50s = 260 and 540 nM, respectively, for the human enzymes). Teneligliptin (0.03-1 mg/kg) inhibits increases in plasma glucose levels in an oral glucose tolerance test in Zucker fatty rats. It reduces body weight, inhibits hepatic steatosis, and decreases plasma insulin levels in a mouse model of high-fat diet-induced obesity when administered at doses of 30 and 60 mg/kg.{46688} Teneligliptin scavenges hydroxyl radicals in a cell-free assay (IC50 = 0.315 mM) and decreases urinary levels of 8-hydroxy-2′-deoxyguanosine (8-OHdG; Item No. 89320), a marker of oxidative stress, in a DPP-4-deficient rat model of diabetes induced by streptozotocin (STZ; Item No. 13104) when administered at a dose of 10 mg/kg per day.{46689}
Brand:CaymanSKU:29515 - 500 mgAvailable on backorder
Tenellin is a fungal metabolite that has been found in Beauveria.{46283} It inhibits Mg2+-, Ca2+-, and Na+/K+-ATPase activities in equine erythrocytes by 51, 57, and 74%, respectively, when used at a concentration of 200 μg/ml.{46283} Tenellin is cytotoxic to Sf9 and Sf21 insect cells with 50% cytotoxic concentration (CC50) values of 4.84 and 11.95 μM, respectively.{46284}
Brand:CaymanSKU:28090 - 1 mgAvailable on backorder
Tenellin is a fungal metabolite that has been found in Beauveria.{46283} It inhibits Mg2+-, Ca2+-, and Na+/K+-ATPase activities in equine erythrocytes by 51, 57, and 74%, respectively, when used at a concentration of 200 μg/ml.{46283} Tenellin is cytotoxic to Sf9 and Sf21 insect cells with 50% cytotoxic concentration (CC50) values of 4.84 and 11.95 μM, respectively.{46284}
Brand:CaymanSKU:28090 - 5 mgAvailable on backorder
Tenidap is a COX-1 selective non-steroidal anti-inflammatory drug (IC50s = 30 µM for COX-1, COX-2, and 5-lipoxygenase (5-LO), respectively).{5386} It has anti-inflammatory and antirheumatic properties.{5386,34222} In vitro, it inhibits prostaglandin D2 (PGD2), leukotriene B4 (LTB4), and prostaglandin E2 (PGE2) synthesis (IC50s = 0.02, 18, and 32 µM, respectively).{34224,34225} Tenidap also reversibly and dose-dependently activates hKir2.3 channels in CHO cells (EC50 = 402 nM) and inhibits fatty acid amide hydrolase (FAAH) activity.{34223,25933} A formulation containing tenidap was not approved for rheumatoid and osteoarthritis by the FDA due to adverse effects, including bone mineralization loss, as well as liver and kidney toxicity.
Brand:CaymanSKU:-Available on backorder
Tenidap is a COX-1 selective non-steroidal anti-inflammatory drug (IC50s = 30 µM for COX-1, COX-2, and 5-lipoxygenase (5-LO), respectively).{5386} It has anti-inflammatory and antirheumatic properties.{5386,34222} In vitro, it inhibits prostaglandin D2 (PGD2), leukotriene B4 (LTB4), and prostaglandin E2 (PGE2) synthesis (IC50s = 0.02, 18, and 32 µM, respectively).{34224,34225} Tenidap also reversibly and dose-dependently activates hKir2.3 channels in CHO cells (EC50 = 402 nM) and inhibits fatty acid amide hydrolase (FAAH) activity.{34223,25933} A formulation containing tenidap was not approved for rheumatoid and osteoarthritis by the FDA due to adverse effects, including bone mineralization loss, as well as liver and kidney toxicity.
Brand:CaymanSKU:-Available on backorder
Tenidap is a COX-1 selective non-steroidal anti-inflammatory drug (IC50s = 30 µM for COX-1, COX-2, and 5-lipoxygenase (5-LO), respectively).{5386} It has anti-inflammatory and antirheumatic properties.{5386,34222} In vitro, it inhibits prostaglandin D2 (PGD2), leukotriene B4 (LTB4), and prostaglandin E2 (PGE2) synthesis (IC50s = 0.02, 18, and 32 µM, respectively).{34224,34225} Tenidap also reversibly and dose-dependently activates hKir2.3 channels in CHO cells (EC50 = 402 nM) and inhibits fatty acid amide hydrolase (FAAH) activity.{34223,25933} A formulation containing tenidap was not approved for rheumatoid and osteoarthritis by the FDA due to adverse effects, including bone mineralization loss, as well as liver and kidney toxicity.
Brand:CaymanSKU:-Available on backorder
Teniposide is a podophyllotoxin derivative that causes dose-dependent single- and double-stranded breaks in DNA by inhibiting topoisomerase II. Its cytostatic effects are related to its ability to stabilize the DNA-topoisomerase II complex during DNA replication, inducing DNA damage and cellular apoptosis.{22985} Teniposide has been widely used in the treatment of various cancers including, small cell lung cancer, malignant lymphoma, breast cancer, oral squamous cell carcinoma, and acute lymphoblastic leukemia.{22986}
Brand:CaymanSKU:- Teniposide is a podophyllotoxin derivative that causes dose-dependent single- and double-stranded breaks in DNA by inhibiting topoisomerase II. Its cytostatic effects are related to its ability to stabilize the DNA-topoisomerase II complex during DNA replication, inducing DNA damage and cellular apoptosis.{22985} Teniposide has been widely used in the treatment of various cancers including, small cell lung cancer, malignant lymphoma, breast cancer, oral squamous cell carcinoma, and acute lymphoblastic leukemia.{22986}
Brand:CaymanSKU:- Teniposide is a podophyllotoxin derivative that causes dose-dependent single- and double-stranded breaks in DNA by inhibiting topoisomerase II. Its cytostatic effects are related to its ability to stabilize the DNA-topoisomerase II complex during DNA replication, inducing DNA damage and cellular apoptosis.{22985} Teniposide has been widely used in the treatment of various cancers including, small cell lung cancer, malignant lymphoma, breast cancer, oral squamous cell carcinoma, and acute lymphoblastic leukemia.{22986}
Brand:CaymanSKU:- Teniposide is a podophyllotoxin derivative that causes dose-dependent single- and double-stranded breaks in DNA by inhibiting topoisomerase II. Its cytostatic effects are related to its ability to stabilize the DNA-topoisomerase II complex during DNA replication, inducing DNA damage and cellular apoptosis.{22985} Teniposide has been widely used in the treatment of various cancers including, small cell lung cancer, malignant lymphoma, breast cancer, oral squamous cell carcinoma, and acute lymphoblastic leukemia.{22986}
Brand:CaymanSKU:-
Tenofovir is an analog of adenosine monophosphate that has antiviral activity.{24520,24521} It is converted by cellular enzymes to tenofovir diphosphate, an obligate chain terminator that inhibits the activity of HIV reverse transcriptase and hepatitis B virus polymerase.{24519,24528} Tenofovir diphosphate is a weak inhibitor of mammalian DNA polymerases α and β and mitochondrial DNA polymerase γ.{24528} For in vivo and cell culture use, tenofovir is supplied as a water soluble prodrug in the form of tenofovir disoproxil (fumarate) (Item No. 16922), which increases the intracellular diphosphorylated compound >1,000-fold above the level attained with unmodified tenofovir.{24528}
Brand:CaymanSKU:- Tenofovir is an analog of adenosine monophosphate that has antiviral activity.{24520,24521} It is converted by cellular enzymes to tenofovir diphosphate, an obligate chain terminator that inhibits the activity of HIV reverse transcriptase and hepatitis B virus polymerase.{24519,24528} Tenofovir diphosphate is a weak inhibitor of mammalian DNA polymerases α and β and mitochondrial DNA polymerase γ.{24528} For in vivo and cell culture use, tenofovir is supplied as a water soluble prodrug in the form of tenofovir disoproxil (fumarate) (Item No. 16922), which increases the intracellular diphosphorylated compound >1,000-fold above the level attained with unmodified tenofovir.{24528}
Brand:CaymanSKU:- Tenofovir is an analog of adenosine monophosphate that has antiviral activity.{24520,24521} It is converted by cellular enzymes to tenofovir diphosphate, an obligate chain terminator that inhibits the activity of HIV reverse transcriptase and hepatitis B virus polymerase.{24519,24528} Tenofovir diphosphate is a weak inhibitor of mammalian DNA polymerases α and β and mitochondrial DNA polymerase γ.{24528} For in vivo and cell culture use, tenofovir is supplied as a water soluble prodrug in the form of tenofovir disoproxil (fumarate) (Item No. 16922), which increases the intracellular diphosphorylated compound >1,000-fold above the level attained with unmodified tenofovir.{24528}
Brand:CaymanSKU:- Tenofovir is an analog of adenosine monophosphate that has antiviral activity.{24520,24521} It is converted by cellular enzymes to tenofovir diphosphate, an obligate chain terminator that inhibits the activity of HIV reverse transcriptase and hepatitis B virus polymerase.{24519,24528} Tenofovir diphosphate is a weak inhibitor of mammalian DNA polymerases α and β and mitochondrial DNA polymerase γ.{24528} For in vivo and cell culture use, tenofovir is supplied as a water soluble prodrug in the form of tenofovir disoproxil (fumarate) (Item No. 16922), which increases the intracellular diphosphorylated compound >1,000-fold above the level attained with unmodified tenofovir.{24528}
Brand:CaymanSKU:-
Tenofovir disoproxil is a prodrug of the acyclic nucleoside phosphonate, tenofovir (Item No. 13874).{22168,24528} Tenofovir is converted by cellular enzymes to tenofovir diphosphate, an obligate chain terminator that inhibits the activity of HIV reverse transcriptase and hepatitis B virus polymerase.{24520,24521} Due to its rapid intracellular uptake, the anti-HIV activity of tenofovir disoproxil is reportedly >100-fold greater than that of the negatively charged tenofovir in a T cell line and primary blood lymphocytes.{24528}
Brand:CaymanSKU:-Out of stock
Tenofovir disoproxil is a prodrug of the acyclic nucleoside phosphonate, tenofovir (Item No. 13874).{22168,24528} Tenofovir is converted by cellular enzymes to tenofovir diphosphate, an obligate chain terminator that inhibits the activity of HIV reverse transcriptase and hepatitis B virus polymerase.{24520,24521} Due to its rapid intracellular uptake, the anti-HIV activity of tenofovir disoproxil is reportedly >100-fold greater than that of the negatively charged tenofovir in a T cell line and primary blood lymphocytes.{24528}
Brand:CaymanSKU:-Out of stock
Tenofovir disoproxil is a prodrug of the acyclic nucleoside phosphonate, tenofovir (Item No. 13874).{22168,24528} Tenofovir is converted by cellular enzymes to tenofovir diphosphate, an obligate chain terminator that inhibits the activity of HIV reverse transcriptase and hepatitis B virus polymerase.{24520,24521} Due to its rapid intracellular uptake, the anti-HIV activity of tenofovir disoproxil is reportedly >100-fold greater than that of the negatively charged tenofovir in a T cell line and primary blood lymphocytes.{24528}
Brand:CaymanSKU:-Out of stock
Tenofovir disoproxil is a prodrug of the acyclic nucleoside phosphonate, tenofovir (Item No. 13874).{22168,24528} Tenofovir is converted by cellular enzymes to tenofovir diphosphate, an obligate chain terminator that inhibits the activity of HIV reverse transcriptase and hepatitis B virus polymerase.{24520,24521} Due to its rapid intracellular uptake, the anti-HIV activity of tenofovir disoproxil is reportedly >100-fold greater than that of the negatively charged tenofovir in a T cell line and primary blood lymphocytes.{24528}
Brand:CaymanSKU:-Out of stock
Tenofovir-d6 is intended for use as an internal standard for the quantification of tenofovir (Item No. 13874) by GC- or LC-MS. Tenofovir is an analog of adenosine monophosphate that has antiviral activity.{24520,24521} It is converted by cellular enzymes to tenofovir diphosphate, an obligate chain terminator that inhibits the activity of HIV reverse transcriptase and hepatitis B virus polymerase.{24519,24528} Tenofovir diphosphate is a weak inhibitor of mammalian DNA polymerases α and β and mitochondrial DNA polymerase γ.{24528} For in vivo and cell culture use, tenofovir is supplied as a water soluble prodrug in the form of tenofovir disoproxil (fumarate) (Item No. 16922), which increases the intracellular diphosphorylated compound >1,000-fold above the level attained with unmodified tenofovir.
Brand:CaymanSKU:21071 -Out of stock
Tenofovir-d6 is intended for use as an internal standard for the quantification of tenofovir (Item No. 13874) by GC- or LC-MS. Tenofovir is an analog of adenosine monophosphate that has antiviral activity.{24520,24521} It is converted by cellular enzymes to tenofovir diphosphate, an obligate chain terminator that inhibits the activity of HIV reverse transcriptase and hepatitis B virus polymerase.{24519,24528} Tenofovir diphosphate is a weak inhibitor of mammalian DNA polymerases α and β and mitochondrial DNA polymerase γ.{24528} For in vivo and cell culture use, tenofovir is supplied as a water soluble prodrug in the form of tenofovir disoproxil (fumarate) (Item No. 16922), which increases the intracellular diphosphorylated compound >1,000-fold above the level attained with unmodified tenofovir.
Brand:CaymanSKU:21071 -Out of stock
Tenovin-1 is a small molecule activator of p53 transcriptional activity. At 10 µM, it elevates p53 expression in MCF-7 cells within two hours of treatment and longer-term exposure significantly decreases the growth of BL2 Burkitt’s lymphoma and ARN8 melanoma cells.{16243} Functioning upstream of p53, tenovin-1 acts by inhibiting the deacetylase activity of purified human SIRT1 and SIRT2, members of NAD+-dependent class III histone deacetylases that belong to the sirtuin family.{16243} While tenovin-1 demonstrates low genotoxicity, the compound has poor water solubility, which limits its uses in vivo.
Brand:CaymanSKU:- Tenovin-1 is a small molecule activator of p53 transcriptional activity. At 10 µM, it elevates p53 expression in MCF-7 cells within two hours of treatment and longer-term exposure significantly decreases the growth of BL2 Burkitt’s lymphoma and ARN8 melanoma cells.{16243} Functioning upstream of p53, tenovin-1 acts by inhibiting the deacetylase activity of purified human SIRT1 and SIRT2, members of NAD+-dependent class III histone deacetylases that belong to the sirtuin family.{16243} While tenovin-1 demonstrates low genotoxicity, the compound has poor water solubility, which limits its uses in vivo.
Brand:CaymanSKU:- Tenovin-1 is a small molecule activator of p53 transcriptional activity. At 10 µM, it elevates p53 expression in MCF-7 cells within two hours of treatment and longer-term exposure significantly decreases the growth of BL2 Burkitt’s lymphoma and ARN8 melanoma cells.{16243} Functioning upstream of p53, tenovin-1 acts by inhibiting the deacetylase activity of purified human SIRT1 and SIRT2, members of NAD+-dependent class III histone deacetylases that belong to the sirtuin family.{16243} While tenovin-1 demonstrates low genotoxicity, the compound has poor water solubility, which limits its uses in vivo.
Brand:CaymanSKU:-