Cayman
Showing 40651–40800 of 45550 results
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Succinimidyl 4-formylbenzoate is a heterobifunctional building block.{46973,46974} It has been used in the conjugation of oligonucleotides to antibodies for protein detection, as well as in the synthesis of fluorescent BODIPY-etoposide.
Brand:CaymanSKU:30477 - 50 mgAvailable on backorder
Succinobucol is a metabolically stable derivative of probucol (Item No. 15043) with diverse biological activities.{52866,52868,52867} It inhibits hydrogen peroxide-induced oxidation of the redox-sensitive dye H2DCF in human pulmonary artery endothelial cells (HPAECs) and U937 cells when used at concentrations of 5 and 10 µM.{52866} Succinobucol (0.3-10 µM) reduces LPS-induced production of IL-6, IL-1β, and TNF-α in peripheral blood mononuclear cells (PBMCs). It suppresses TNF-α-induced vascular cell adhesion molecule 1 (VCAM-1) promoter reporter gene expression in human aortic endothelial cells.{52868} Succinobucol (50 and 100 mg/kg) lowers plasma LDL levels and increases HDL levels in hypercholesterolemic cynomolgus monkeys.{52867} It also inhibits the formation of aortic atherosclerotic plaques in ApoE-/- or Ldlr-/- mice.
Brand:CaymanSKU:30886 - 10 mgAvailable on backorder
Succinobucol is a metabolically stable derivative of probucol (Item No. 15043) with diverse biological activities.{52866,52868,52867} It inhibits hydrogen peroxide-induced oxidation of the redox-sensitive dye H2DCF in human pulmonary artery endothelial cells (HPAECs) and U937 cells when used at concentrations of 5 and 10 µM.{52866} Succinobucol (0.3-10 µM) reduces LPS-induced production of IL-6, IL-1β, and TNF-α in peripheral blood mononuclear cells (PBMCs). It suppresses TNF-α-induced vascular cell adhesion molecule 1 (VCAM-1) promoter reporter gene expression in human aortic endothelial cells.{52868} Succinobucol (50 and 100 mg/kg) lowers plasma LDL levels and increases HDL levels in hypercholesterolemic cynomolgus monkeys.{52867} It also inhibits the formation of aortic atherosclerotic plaques in ApoE-/- or Ldlr-/- mice.
Brand:CaymanSKU:30886 - 100 mgAvailable on backorder
Succinobucol is a metabolically stable derivative of probucol (Item No. 15043) with diverse biological activities.{52866,52868,52867} It inhibits hydrogen peroxide-induced oxidation of the redox-sensitive dye H2DCF in human pulmonary artery endothelial cells (HPAECs) and U937 cells when used at concentrations of 5 and 10 µM.{52866} Succinobucol (0.3-10 µM) reduces LPS-induced production of IL-6, IL-1β, and TNF-α in peripheral blood mononuclear cells (PBMCs). It suppresses TNF-α-induced vascular cell adhesion molecule 1 (VCAM-1) promoter reporter gene expression in human aortic endothelial cells.{52868} Succinobucol (50 and 100 mg/kg) lowers plasma LDL levels and increases HDL levels in hypercholesterolemic cynomolgus monkeys.{52867} It also inhibits the formation of aortic atherosclerotic plaques in ApoE-/- or Ldlr-/- mice.
Brand:CaymanSKU:30886 - 25 mgAvailable on backorder
Succinobucol is a metabolically stable derivative of probucol (Item No. 15043) with diverse biological activities.{52866,52868,52867} It inhibits hydrogen peroxide-induced oxidation of the redox-sensitive dye H2DCF in human pulmonary artery endothelial cells (HPAECs) and U937 cells when used at concentrations of 5 and 10 µM.{52866} Succinobucol (0.3-10 µM) reduces LPS-induced production of IL-6, IL-1β, and TNF-α in peripheral blood mononuclear cells (PBMCs). It suppresses TNF-α-induced vascular cell adhesion molecule 1 (VCAM-1) promoter reporter gene expression in human aortic endothelial cells.{52868} Succinobucol (50 and 100 mg/kg) lowers plasma LDL levels and increases HDL levels in hypercholesterolemic cynomolgus monkeys.{52867} It also inhibits the formation of aortic atherosclerotic plaques in ApoE-/- or Ldlr-/- mice.
Brand:CaymanSKU:30886 - 50 mgAvailable on backorder
Succinyl-coenzyme A (succinyl-CoA) is an intermediate in the citric acid cycle.{41077} It is converted to succinate, which is a metabolic intermediate with various biological activities. Succinyl-CoA is required, with glycine, to form δ-aminolevulinic acid in the first step of porphyrin and heme synthesis.{41076} Succinyl-CoA deficiency, caused by vitamin B12 (Item No. 18425) deficiency can disrupt heme and energy production, leading to neuromotor dysfunction.{41075}
Brand:CaymanSKU:23297 - 1 mgAvailable on backorder
Succinyl-coenzyme A (succinyl-CoA) is an intermediate in the citric acid cycle.{41077} It is converted to succinate, which is a metabolic intermediate with various biological activities. Succinyl-CoA is required, with glycine, to form δ-aminolevulinic acid in the first step of porphyrin and heme synthesis.{41076} Succinyl-CoA deficiency, caused by vitamin B12 (Item No. 18425) deficiency can disrupt heme and energy production, leading to neuromotor dysfunction.{41075}
Brand:CaymanSKU:23297 - 10 mgAvailable on backorder
Succinyl-coenzyme A (succinyl-CoA) is an intermediate in the citric acid cycle.{41077} It is converted to succinate, which is a metabolic intermediate with various biological activities. Succinyl-CoA is required, with glycine, to form δ-aminolevulinic acid in the first step of porphyrin and heme synthesis.{41076} Succinyl-CoA deficiency, caused by vitamin B12 (Item No. 18425) deficiency can disrupt heme and energy production, leading to neuromotor dysfunction.{41075}
Brand:CaymanSKU:23297 - 5 mgAvailable on backorder
Succinylacetone is an inhibitor of δ-aminolevulinic acid dehydratase (Ki = 300 nM for human erythrocyte enzyme).{36832} It inhibits heme biosynthesis and decreases the growth of murine erythroleukemia cells when used at concentrations of 0.1 and 1 mM.{36833} Succinylacetone is an abnormal metabolite of tyrosine that accumulates in hereditary tyrosinemia type I, a disorder characterized by a deficiency in fumarylacetoacetate hydrolase (FAH), the final enzyme in tyrosine catabolism.{36834} Without functional FAH, fumarylacetoacetate is converted into succinylacetone. In a rat model of hypertyrosinemia, succinylacetone (40 mg/kg twice daily) increases levels of δ-aminolevulinic acid in urine, decreases heme levels in liver, kidney, spleen, and vascular tissues, and reduces sensitivity of isolated rat aortic rings to endothelium-dependent and -independent vasodilation. Increased levels of succinylacetone has been used as a marker of tyrosinemia type 1.{36835}
Brand:CaymanSKU:25501 - 10 mgAvailable on backorder
Succinylacetone is an inhibitor of δ-aminolevulinic acid dehydratase (Ki = 300 nM for human erythrocyte enzyme).{36832} It inhibits heme biosynthesis and decreases the growth of murine erythroleukemia cells when used at concentrations of 0.1 and 1 mM.{36833} Succinylacetone is an abnormal metabolite of tyrosine that accumulates in hereditary tyrosinemia type I, a disorder characterized by a deficiency in fumarylacetoacetate hydrolase (FAH), the final enzyme in tyrosine catabolism.{36834} Without functional FAH, fumarylacetoacetate is converted into succinylacetone. In a rat model of hypertyrosinemia, succinylacetone (40 mg/kg twice daily) increases levels of δ-aminolevulinic acid in urine, decreases heme levels in liver, kidney, spleen, and vascular tissues, and reduces sensitivity of isolated rat aortic rings to endothelium-dependent and -independent vasodilation. Increased levels of succinylacetone has been used as a marker of tyrosinemia type 1.{36835}
Brand:CaymanSKU:25501 - 100 mgAvailable on backorder
Succinylacetone is an inhibitor of δ-aminolevulinic acid dehydratase (Ki = 300 nM for human erythrocyte enzyme).{36832} It inhibits heme biosynthesis and decreases the growth of murine erythroleukemia cells when used at concentrations of 0.1 and 1 mM.{36833} Succinylacetone is an abnormal metabolite of tyrosine that accumulates in hereditary tyrosinemia type I, a disorder characterized by a deficiency in fumarylacetoacetate hydrolase (FAH), the final enzyme in tyrosine catabolism.{36834} Without functional FAH, fumarylacetoacetate is converted into succinylacetone. In a rat model of hypertyrosinemia, succinylacetone (40 mg/kg twice daily) increases levels of δ-aminolevulinic acid in urine, decreases heme levels in liver, kidney, spleen, and vascular tissues, and reduces sensitivity of isolated rat aortic rings to endothelium-dependent and -independent vasodilation. Increased levels of succinylacetone has been used as a marker of tyrosinemia type 1.{36835}
Brand:CaymanSKU:25501 - 250 mgAvailable on backorder
Succinylacetone is an inhibitor of δ-aminolevulinic acid dehydratase (Ki = 300 nM for human erythrocyte enzyme).{36832} It inhibits heme biosynthesis and decreases the growth of murine erythroleukemia cells when used at concentrations of 0.1 and 1 mM.{36833} Succinylacetone is an abnormal metabolite of tyrosine that accumulates in hereditary tyrosinemia type I, a disorder characterized by a deficiency in fumarylacetoacetate hydrolase (FAH), the final enzyme in tyrosine catabolism.{36834} Without functional FAH, fumarylacetoacetate is converted into succinylacetone. In a rat model of hypertyrosinemia, succinylacetone (40 mg/kg twice daily) increases levels of δ-aminolevulinic acid in urine, decreases heme levels in liver, kidney, spleen, and vascular tissues, and reduces sensitivity of isolated rat aortic rings to endothelium-dependent and -independent vasodilation. Increased levels of succinylacetone has been used as a marker of tyrosinemia type 1.{36835}
Brand:CaymanSKU:25501 - 50 mgAvailable on backorder
Antigen: human SUCNR1 amino acids 100-150 • Host: rabbit • Cross Reactivity: (+) human, chimpanzee, new world monkey SUCNR1; predicted to react with dog, mouse, and rat SUCNR1 • Application(s): IHC and WB • SUCNR1 is a receptor for the citric acid cycle intermediate succinate that functions in establishing a neovascular network during development and in response to injury. It regulates the production of numerous angiogenic factors, including VEGF, and also is involved in the modulation of platelet function.
Brand:CaymanSKU:10928- 1 eaAvailable on backorder
Antigen: human SUCNR1 amino acids 100-150 • Host: rabbit • Cross Reactivity: (+) human, chimpanzee, new world monkey SUCNR1; predicted to react with dog, mouse, and rat SUCNR1 • Application(s): IHC and WB • SUCNR1 is a receptor for the citric acid cycle intermediate succinate that functions in establishing a neovascular network during development and in response to injury. It regulates the production of numerous angiogenic factors, including VEGF, and also is involved in the modulation of platelet function.
Brand:CaymanSKU:10928- 1 ea SUCNR1 is a 334 amino acid-containing membrane receptor, belonging to the G-protein coupled receptor 1 family, characterized by an extracellular N terminus, seven transmembrane regions, and an intracellular C terminus and playing a role in cell communication.{19519,19520} SUCNR1 is a receptor for the citric acid cycle intermediate succinate. It functions in establishing a neovascular network during development and in response to injury. SUCNR1, in response to increased succinate levels, regulates the production of numerous angiogenic factors, including VEGF, and also is involved in the modulation of platelet function. It is known to play an essential role in proliferative ischemic retinopathy and is an attractive target for treating diseases that stem from aberrant neovascularization in the mature retina such as diabetic retinopathy. Expression of SUCNR1 is common in kidney, liver, retina, platelets, and leukocytes.
Brand:CaymanSKU:10928 - 1 eaAvailable on backorder
Sucralfate is a basic aluminum sucrose sulfate complex that has gastroprotective activity.{46263} It inhibits rat pepsin in a concentration-dependent manner and pepsin activity in isolated human gastric juice. It also inhibits ulcer formation induced by pyloric ligation, indomethacin (Item No. 70270), or cysteamine (Item No. 22193) in rats. Sucralfate (5,600 mg/animal) is protective against neutral ethanol and acidified taurocholic acid-induced damage in a rat model of hydrochloric acid-induced gastric mucosal damage, increasing the pH and reducing the disappearance of hydrogen ions.{46264} Formulations containing sucralfate have been used as antacids in the treatment of duodenal ulcer.
Brand:CaymanSKU:27882 - 1 gAvailable on backorder
Sucralfate is a basic aluminum sucrose sulfate complex that has gastroprotective activity.{46263} It inhibits rat pepsin in a concentration-dependent manner and pepsin activity in isolated human gastric juice. It also inhibits ulcer formation induced by pyloric ligation, indomethacin (Item No. 70270), or cysteamine (Item No. 22193) in rats. Sucralfate (5,600 mg/animal) is protective against neutral ethanol and acidified taurocholic acid-induced damage in a rat model of hydrochloric acid-induced gastric mucosal damage, increasing the pH and reducing the disappearance of hydrogen ions.{46264} Formulations containing sucralfate have been used as antacids in the treatment of duodenal ulcer.
Brand:CaymanSKU:27882 - 500 mgAvailable on backorder
Sucralose is a synthetic disaccharide and non-caloric sweetener.{52811,52812} It is not readily metabolized in humans and has been found as a contaminant in wastewater.{52812} Formulations containing sucralose reduce Bifidobacterium, Lactobacillus, Bacteroides, and Clostridium bacterial counts in the gastrointestinal tract and increase fecal pH in rats.{52811}
Brand:CaymanSKU:31621 - 100 gAvailable on backorder
Sucralose is a synthetic disaccharide and non-caloric sweetener.{52811,52812} It is not readily metabolized in humans and has been found as a contaminant in wastewater.{52812} Formulations containing sucralose reduce Bifidobacterium, Lactobacillus, Bacteroides, and Clostridium bacterial counts in the gastrointestinal tract and increase fecal pH in rats.{52811}
Brand:CaymanSKU:31621 - 25 gAvailable on backorder
Sucralose is a synthetic disaccharide and non-caloric sweetener.{52811,52812} It is not readily metabolized in humans and has been found as a contaminant in wastewater.{52812} Formulations containing sucralose reduce Bifidobacterium, Lactobacillus, Bacteroides, and Clostridium bacterial counts in the gastrointestinal tract and increase fecal pH in rats.{52811}
Brand:CaymanSKU:31621 - 250 gAvailable on backorder
Sucralose is a synthetic disaccharide and non-caloric sweetener.{52811,52812} It is not readily metabolized in humans and has been found as a contaminant in wastewater.{52812} Formulations containing sucralose reduce Bifidobacterium, Lactobacillus, Bacteroides, and Clostridium bacterial counts in the gastrointestinal tract and increase fecal pH in rats.{52811}
Brand:CaymanSKU:31621 - 50 gAvailable on backorder
Sucralose-d6 contains six deuterium atoms. It is intended for use as an internal standard for the quantification of sucralose by GC- or LC-MS.{38050,38048} Sucralose is a non-caloric chlorinated disaccharide used as a sugar alternative that is not metabolized by humans.{38049} Excreted sucralose collects in wastewater and is considered a pollutant.{38050,38048}
Brand:CaymanSKU:22176 -Out of stock
Sucralfate is a gastrointestinal protectant that includes sucrose octasulfate (Item No. 16382). Sucralfate protects gastric epithelial cells against acid- and pepsin-induced damage.{26737} Sucrose hexasulfate is a polysulfated disaccharide that is used as a reference standard for sucralfate.{29464}
Brand:CaymanSKU:-Available on backorder
Sucralfate is a gastrointestinal protectant that includes sucrose octasulfate (Item No. 16382). Sucralfate protects gastric epithelial cells against acid- and pepsin-induced damage.{26737} Sucrose hexasulfate is a polysulfated disaccharide that is used as a reference standard for sucralfate.{29464}
Brand:CaymanSKU:-Available on backorder
Sucralfate is a gastrointestinal protectant that includes sucrose octasulfate (Item No. 16382). Sucralfate protects gastric epithelial cells against acid- and pepsin-induced damage.{26737} Sucrose hexasulfate is a polysulfated disaccharide that is used as a reference standard for sucralfate.{29464}
Brand:CaymanSKU:-Available on backorder
Sucrose octasulfate (SOS), a component of the gastrointestinal protectant sucralfate, is an alkaline aluminum−sucrose complex that inhibits peptic hydrolysis and raises gastric pH, protecting esophageal epithelium against acid injury.{26737} It can bind to exosite II of thrombin (KD = ~1.4 µM) and inhibit its catalytic activity (IC50 = 4.5 µM) and, as such, has been used as a surrogate for heparin.{26734} Furthermore, SOS has been shown to inhibit tumor growth in mouse melanoma and lung carcinoma models by preventing fibroblast growth factor 2 (FGF-2) binding to endothelial cells and also by removing any pre-bound FGF-2 from these cells (IC50 = ~2 µg/ml).{26736}
Brand:CaymanSKU:-Out of stock
Sucrose octasulfate (SOS), a component of the gastrointestinal protectant sucralfate, is an alkaline aluminum−sucrose complex that inhibits peptic hydrolysis and raises gastric pH, protecting esophageal epithelium against acid injury.{26737} It can bind to exosite II of thrombin (KD = ~1.4 µM) and inhibit its catalytic activity (IC50 = 4.5 µM) and, as such, has been used as a surrogate for heparin.{26734} Furthermore, SOS has been shown to inhibit tumor growth in mouse melanoma and lung carcinoma models by preventing fibroblast growth factor 2 (FGF-2) binding to endothelial cells and also by removing any pre-bound FGF-2 from these cells (IC50 = ~2 µg/ml).{26736}
Brand:CaymanSKU:-Out of stock
Sucrose octasulfate (SOS), a component of the gastrointestinal protectant sucralfate, is an alkaline aluminum−sucrose complex that inhibits peptic hydrolysis and raises gastric pH, protecting esophageal epithelium against acid injury.{26737} It can bind to exosite II of thrombin (KD = ~1.4 µM) and inhibit its catalytic activity (IC50 = 4.5 µM) and, as such, has been used as a surrogate for heparin.{26734} Furthermore, SOS has been shown to inhibit tumor growth in mouse melanoma and lung carcinoma models by preventing fibroblast growth factor 2 (FGF-2) binding to endothelial cells and also by removing any pre-bound FGF-2 from these cells (IC50 = ~2 µg/ml).{26736}
Brand:CaymanSKU:-Out of stock
Sufugolix is a gonadotropin-releasing hormone (GnRH) receptor antagonist (IC50 = 0.1 nM).{45410} Sufugolix inhibits GnRH-induced arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) release in CHO cells expressing human recombinant or monkey recombinant GnRH (IC50s = 0.1 and 10 nM, respectively), but not the rat GnRH receptor. It inhibits luteinizing hormone (LH) release stimulated by GnRH in monkey pituitary cells ex vivo (IC50 = 36 nM).{45411} Sufugolix (10 and 30 mg/kg) reduces increases in plasma LH following castration in male cynomolgus monkeys and lowers serum LH, estradiol, and progesterone levels in female cynomolgus monkeys when administered at a dose of 90 mg/kg.{45410,45411}
Brand:CaymanSKU:27996 - 1 mgAvailable on backorder
Sufugolix is a gonadotropin-releasing hormone (GnRH) receptor antagonist (IC50 = 0.1 nM).{45410} Sufugolix inhibits GnRH-induced arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) release in CHO cells expressing human recombinant or monkey recombinant GnRH (IC50s = 0.1 and 10 nM, respectively), but not the rat GnRH receptor. It inhibits luteinizing hormone (LH) release stimulated by GnRH in monkey pituitary cells ex vivo (IC50 = 36 nM).{45411} Sufugolix (10 and 30 mg/kg) reduces increases in plasma LH following castration in male cynomolgus monkeys and lowers serum LH, estradiol, and progesterone levels in female cynomolgus monkeys when administered at a dose of 90 mg/kg.{45410,45411}
Brand:CaymanSKU:27996 - 10 mgAvailable on backorder
Sufugolix is a gonadotropin-releasing hormone (GnRH) receptor antagonist (IC50 = 0.1 nM).{45410} Sufugolix inhibits GnRH-induced arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) release in CHO cells expressing human recombinant or monkey recombinant GnRH (IC50s = 0.1 and 10 nM, respectively), but not the rat GnRH receptor. It inhibits luteinizing hormone (LH) release stimulated by GnRH in monkey pituitary cells ex vivo (IC50 = 36 nM).{45411} Sufugolix (10 and 30 mg/kg) reduces increases in plasma LH following castration in male cynomolgus monkeys and lowers serum LH, estradiol, and progesterone levels in female cynomolgus monkeys when administered at a dose of 90 mg/kg.{45410,45411}
Brand:CaymanSKU:27996 - 5 mgAvailable on backorder
Sugammadex is a synthetic derivative of γ-cyclodextrin and a steroid-based neuromuscular blocker reversing agent.{40796} It binds rocuronium (Item No. 23698) within its cyclodextrin ring and selectively reverses rocuronium-induced neuromuscular blockade over that induced by mivacurium (Item No. 23610) or atracurium (Item No. 17796) in anesthetized rhesus monkeys. Sugammadex also prevents formation of postoperative peritoneal adhesions in rats.{40797} In a rat model of ischemia-reperfusion injury, sugammadex (16 and 100 mg/kg) increases the total number of neurons in the hippocampus compared to control and improves motor coordination in a beam walking test.{40798}
Brand:CaymanSKU:24096 - 1 mgAvailable on backorder
Sugammadex is a synthetic derivative of γ-cyclodextrin and a steroid-based neuromuscular blocker reversing agent.{40796} It binds rocuronium (Item No. 23698) within its cyclodextrin ring and selectively reverses rocuronium-induced neuromuscular blockade over that induced by mivacurium (Item No. 23610) or atracurium (Item No. 17796) in anesthetized rhesus monkeys. Sugammadex also prevents formation of postoperative peritoneal adhesions in rats.{40797} In a rat model of ischemia-reperfusion injury, sugammadex (16 and 100 mg/kg) increases the total number of neurons in the hippocampus compared to control and improves motor coordination in a beam walking test.{40798}
Brand:CaymanSKU:24096 - 10 mgAvailable on backorder
Sugammadex is a synthetic derivative of γ-cyclodextrin and a steroid-based neuromuscular blocker reversing agent.{40796} It binds rocuronium (Item No. 23698) within its cyclodextrin ring and selectively reverses rocuronium-induced neuromuscular blockade over that induced by mivacurium (Item No. 23610) or atracurium (Item No. 17796) in anesthetized rhesus monkeys. Sugammadex also prevents formation of postoperative peritoneal adhesions in rats.{40797} In a rat model of ischemia-reperfusion injury, sugammadex (16 and 100 mg/kg) increases the total number of neurons in the hippocampus compared to control and improves motor coordination in a beam walking test.{40798}
Brand:CaymanSKU:24096 - 5 mgAvailable on backorder
β-Lactams are a large class of antibiotics that includes penicillins, cephalosporins, carbapenems, and monobactams.{25960} Resistance against β-lactam antibiotics can result from the production of β-lactamases, which is a common mechanism employed by Gram-negative bacteria.{25960,27765} Sulbactam is a penicillanic acid sulfone that acts as an irreversible inhibitor of β-lactamases.{27903} It is effective against a wide variety of serine β-lactamases produced by common Gram-negative and Gram-positive aerobes and anaerobes.{27902,27900,27901} However, it is not effective against metallo-β-lactamases, cephalosporinases, or oxacillinases.{27901}
Brand:CaymanSKU:- β-Lactams are a large class of antibiotics that includes penicillins, cephalosporins, carbapenems, and monobactams.{25960} Resistance against β-lactam antibiotics can result from the production of β-lactamases, which is a common mechanism employed by Gram-negative bacteria.{25960,27765} Sulbactam is a penicillanic acid sulfone that acts as an irreversible inhibitor of β-lactamases.{27903} It is effective against a wide variety of serine β-lactamases produced by common Gram-negative and Gram-positive aerobes and anaerobes.{27902,27900,27901} However, it is not effective against metallo-β-lactamases, cephalosporinases, or oxacillinases.{27901}
Brand:CaymanSKU:- β-Lactams are a large class of antibiotics that includes penicillins, cephalosporins, carbapenems, and monobactams.{25960} Resistance against β-lactam antibiotics can result from the production of β-lactamases, which is a common mechanism employed by Gram-negative bacteria.{25960,27765} Sulbactam is a penicillanic acid sulfone that acts as an irreversible inhibitor of β-lactamases.{27903} It is effective against a wide variety of serine β-lactamases produced by common Gram-negative and Gram-positive aerobes and anaerobes.{27902,27900,27901} However, it is not effective against metallo-β-lactamases, cephalosporinases, or oxacillinases.{27901}
Brand:CaymanSKU:-
Sulconazole is an azole antifungal that is active against dermatophyte fungal species, including isolates of various Candida species.{38783} It acts as a non-specific inhibitor of styrene metabolism by cytochrome P450 (CYP450) enzymes, with Ki values ranging from 0.008 to 3.5 µM against various CYP450 isoforms in human lymphoblast microsomes in vitro.{38782,38784} In rat spleen microsomes, it inhibits the activity of heme oxygenase 1 with an IC50 value of 1.1 µM.{24647} Sulconazole inhibits DNA damage induced by the metabolism of styrene by bacterial CYP450cam with a Ki value of 204.2 μM in an electrochemical biosensor model.{38782} Formulations containing sulconazole have been used for the treatment of fungal infections.
Brand:CaymanSKU:23800 - 100 mgAvailable on backorder
Sulconazole is an azole antifungal that is active against dermatophyte fungal species, including isolates of various Candida species.{38783} It acts as a non-specific inhibitor of styrene metabolism by cytochrome P450 (CYP450) enzymes, with Ki values ranging from 0.008 to 3.5 µM against various CYP450 isoforms in human lymphoblast microsomes in vitro.{38782,38784} In rat spleen microsomes, it inhibits the activity of heme oxygenase 1 with an IC50 value of 1.1 µM.{24647} Sulconazole inhibits DNA damage induced by the metabolism of styrene by bacterial CYP450cam with a Ki value of 204.2 μM in an electrochemical biosensor model.{38782} Formulations containing sulconazole have been used for the treatment of fungal infections.
Brand:CaymanSKU:23800 - 25 mgAvailable on backorder
Sulconazole is an azole antifungal that is active against dermatophyte fungal species, including isolates of various Candida species.{38783} It acts as a non-specific inhibitor of styrene metabolism by cytochrome P450 (CYP450) enzymes, with Ki values ranging from 0.008 to 3.5 µM against various CYP450 isoforms in human lymphoblast microsomes in vitro.{38782,38784} In rat spleen microsomes, it inhibits the activity of heme oxygenase 1 with an IC50 value of 1.1 µM.{24647} Sulconazole inhibits DNA damage induced by the metabolism of styrene by bacterial CYP450cam with a Ki value of 204.2 μM in an electrochemical biosensor model.{38782} Formulations containing sulconazole have been used for the treatment of fungal infections.
Brand:CaymanSKU:23800 - 250 mgAvailable on backorder
Sulconazole is an azole antifungal that is active against dermatophyte fungal species, including isolates of various Candida species.{38783} It acts as a non-specific inhibitor of styrene metabolism by cytochrome P450 (CYP450) enzymes, with Ki values ranging from 0.008 to 3.5 µM against various CYP450 isoforms in human lymphoblast microsomes in vitro.{38782,38784} In rat spleen microsomes, it inhibits the activity of heme oxygenase 1 with an IC50 value of 1.1 µM.{24647} Sulconazole inhibits DNA damage induced by the metabolism of styrene by bacterial CYP450cam with a Ki value of 204.2 μM in an electrochemical biosensor model.{38782} Formulations containing sulconazole have been used for the treatment of fungal infections.
Brand:CaymanSKU:23800 - 50 mgAvailable on backorder
Sulfacetamide is a sulfonamide antibiotic that is bacteriostatic against Gram-positive and Gram-negative bacteria. It inhibits dihydropteroate synthase (IC50 = 9.6 µM), blocking the synthesis of dihydrofolic acid, and also inhibits bacterial 4-aminobenzoic acid (Item No. 18659), which is required for the synthesis of folic acid.{32069}
Brand:CaymanSKU:20377 -Available on backorder
Sulfacetamide is a sulfonamide antibiotic that is bacteriostatic against Gram-positive and Gram-negative bacteria. It inhibits dihydropteroate synthase (IC50 = 9.6 µM), blocking the synthesis of dihydrofolic acid, and also inhibits bacterial 4-aminobenzoic acid (Item No. 18659), which is required for the synthesis of folic acid.{32069}
Brand:CaymanSKU:20377 -Available on backorder
Sulfacetamide is a sulfonamide antibiotic that is bacteriostatic against Gram-positive and Gram-negative bacteria. It inhibits dihydropteroate synthase (IC50 = 9.6 µM), blocking the synthesis of dihydrofolic acid, and also inhibits bacterial 4-aminobenzoic acid (Item No. 18659), which is required for the synthesis of folic acid.{32069}
Brand:CaymanSKU:20377 -Available on backorder
Sulfaclozine is a sulfonamide antibiotic with antiprotozoal activity.{58152,58153} Dietary administration of sulfaclozine reduces cecal lesion score and oocyst production in a chick model of E. tenella infection in a dose-dependent manner.{58152} It increases average survival time in a mouse model of T. gondii infection when administered at a dose of 250 mg/kg per day.{58153} Sulfaclozine has been found in chicken muscle samples from domestic markets and as an environmental contaminent in fish pond water, biogas digester water, and lagoon wastewater from pig farms.{58154,58155} Formulations containing sulfaclozine have been used in the treatment of coccidiosis in poultry.
Brand:CaymanSKU:31223 - 1 gAvailable on backorder
Sulfaclozine is a sulfonamide antibiotic with antiprotozoal activity.{58152,58153} Dietary administration of sulfaclozine reduces cecal lesion score and oocyst production in a chick model of E. tenella infection in a dose-dependent manner.{58152} It increases average survival time in a mouse model of T. gondii infection when administered at a dose of 250 mg/kg per day.{58153} Sulfaclozine has been found in chicken muscle samples from domestic markets and as an environmental contaminent in fish pond water, biogas digester water, and lagoon wastewater from pig farms.{58154,58155} Formulations containing sulfaclozine have been used in the treatment of coccidiosis in poultry.
Brand:CaymanSKU:31223 - 100 mgAvailable on backorder
Sulfaclozine is a sulfonamide antibiotic with antiprotozoal activity.{58152,58153} Dietary administration of sulfaclozine reduces cecal lesion score and oocyst production in a chick model of E. tenella infection in a dose-dependent manner.{58152} It increases average survival time in a mouse model of T. gondii infection when administered at a dose of 250 mg/kg per day.{58153} Sulfaclozine has been found in chicken muscle samples from domestic markets and as an environmental contaminent in fish pond water, biogas digester water, and lagoon wastewater from pig farms.{58154,58155} Formulations containing sulfaclozine have been used in the treatment of coccidiosis in poultry.
Brand:CaymanSKU:31223 - 250 mgAvailable on backorder
Sulfaclozine is a sulfonamide antibiotic with antiprotozoal activity.{58152,58153} Dietary administration of sulfaclozine reduces cecal lesion score and oocyst production in a chick model of E. tenella infection in a dose-dependent manner.{58152} It increases average survival time in a mouse model of T. gondii infection when administered at a dose of 250 mg/kg per day.{58153} Sulfaclozine has been found in chicken muscle samples from domestic markets and as an environmental contaminent in fish pond water, biogas digester water, and lagoon wastewater from pig farms.{58154,58155} Formulations containing sulfaclozine have been used in the treatment of coccidiosis in poultry.
Brand:CaymanSKU:31223 - 500 mgAvailable on backorder
Sulfadiazine is a sulfonamide antibiotic that inhibits the growth of Gram-positive and Gram-negative bacteria.{38582,36439,36440,36441} It inhibits dihydropteroate synthase (DHPS), which converts a pteridine and 4-aminobenzoic acid (PABA; Item No. 18659) to dihydropteroate, an intermediate in folate biosynthesis.{38582} Sulfadiazine inhibits recombinant P. carinii DHPS (IC50 = 0.19 μM). It inhibits the growth of clinical isolates of M. tuberculosis (MIC90 = 10 mg/L) and of N. meningitidis (MICs = 5-2,000 mg/L).{36439,36440} Sulfadiazine also inhibits the growth of A. pleuropneumoniae, S. choleraesuis, S. typhimurium, P. multocida, S. equi, and S. suis (MIC90 = 16473).{36441} In vivo, sulfadiazine (40 mg/kg per day) results in a 36% 90-day survival in a mouse model of lethal T. gondii infection when used in combination with pyrimethamine (Item No. 16472).{36442} Formulations containing sulfadiazine have been used to treat rheumatic fever and various infections, and, in a dual treatment with pyrimethamine, to treat toxoplasmosis.
Brand:CaymanSKU:23719 - 100 gAvailable on backorder
Sulfadiazine is a sulfonamide antibiotic that inhibits the growth of Gram-positive and Gram-negative bacteria.{38582,36439,36440,36441} It inhibits dihydropteroate synthase (DHPS), which converts a pteridine and 4-aminobenzoic acid (PABA; Item No. 18659) to dihydropteroate, an intermediate in folate biosynthesis.{38582} Sulfadiazine inhibits recombinant P. carinii DHPS (IC50 = 0.19 μM). It inhibits the growth of clinical isolates of M. tuberculosis (MIC90 = 10 mg/L) and of N. meningitidis (MICs = 5-2,000 mg/L).{36439,36440} Sulfadiazine also inhibits the growth of A. pleuropneumoniae, S. choleraesuis, S. typhimurium, P. multocida, S. equi, and S. suis (MIC90 = 16473).{36441} In vivo, sulfadiazine (40 mg/kg per day) results in a 36% 90-day survival in a mouse model of lethal T. gondii infection when used in combination with pyrimethamine (Item No. 16472).{36442} Formulations containing sulfadiazine have been used to treat rheumatic fever and various infections, and, in a dual treatment with pyrimethamine, to treat toxoplasmosis.
Brand:CaymanSKU:23719 - 25 gAvailable on backorder
Sulfadiazine is a sulfonamide antibiotic that inhibits the growth of Gram-positive and Gram-negative bacteria.{38582,36439,36440,36441} It inhibits dihydropteroate synthase (DHPS), which converts a pteridine and 4-aminobenzoic acid (PABA; Item No. 18659) to dihydropteroate, an intermediate in folate biosynthesis.{38582} Sulfadiazine inhibits recombinant P. carinii DHPS (IC50 = 0.19 μM). It inhibits the growth of clinical isolates of M. tuberculosis (MIC90 = 10 mg/L) and of N. meningitidis (MICs = 5-2,000 mg/L).{36439,36440} Sulfadiazine also inhibits the growth of A. pleuropneumoniae, S. choleraesuis, S. typhimurium, P. multocida, S. equi, and S. suis (MIC90 = 16473).{36441} In vivo, sulfadiazine (40 mg/kg per day) results in a 36% 90-day survival in a mouse model of lethal T. gondii infection when used in combination with pyrimethamine (Item No. 16472).{36442} Formulations containing sulfadiazine have been used to treat rheumatic fever and various infections, and, in a dual treatment with pyrimethamine, to treat toxoplasmosis.
Brand:CaymanSKU:23719 - 50 gAvailable on backorder
Sulfadimethoxine is a sulfonamide antibiotic that is active against Gram-negative and Gram-positive bacteria and other microorganisms.{47622} It inhibits recombinant P. carinii dihydropteroate synthase (DHPS; IC50 = 25 nM), an enzyme required for folate biosynthesis, in a cell-free assay.{38582} Sulfadimethoxine is active against S. aureus, S. pneumoniae, K. pneumoniae, and E. coli in a disc assay.{47622} It is also active against C. spiroforme isolates from rabbits (MIC90 = 256 μg/ml) and certain M. bovoculi isolates from keratoconjunctivitis infections in cows (MIC50 = ≤256 μg/ml).{46521,46522} Sulfadimethoxine is efficacious against S. pneumoniae, K. pneumoniae, and E. coli systemic infections in mice with 50% curative dose (CD50) values of 79.7, 2.7, and 12.2 mg/kg, respectively. It is also efficacious against H. capsulatum systemic fungal infections in mice (CD50 = 300 mg/kg).{47622}
Brand:CaymanSKU:28827 - 10 gAvailable on backorder
Sulfadimethoxine is a sulfonamide antibiotic that is active against Gram-negative and Gram-positive bacteria and other microorganisms.{47622} It inhibits recombinant P. carinii dihydropteroate synthase (DHPS; IC50 = 25 nM), an enzyme required for folate biosynthesis, in a cell-free assay.{38582} Sulfadimethoxine is active against S. aureus, S. pneumoniae, K. pneumoniae, and E. coli in a disc assay.{47622} It is also active against C. spiroforme isolates from rabbits (MIC90 = 256 μg/ml) and certain M. bovoculi isolates from keratoconjunctivitis infections in cows (MIC50 = ≤256 μg/ml).{46521,46522} Sulfadimethoxine is efficacious against S. pneumoniae, K. pneumoniae, and E. coli systemic infections in mice with 50% curative dose (CD50) values of 79.7, 2.7, and 12.2 mg/kg, respectively. It is also efficacious against H. capsulatum systemic fungal infections in mice (CD50 = 300 mg/kg).{47622}
Brand:CaymanSKU:28827 - 25 gAvailable on backorder
Sulfadimethoxine is a sulfonamide antibiotic that is active against Gram-negative and Gram-positive bacteria and other microorganisms.{47622} It inhibits recombinant P. carinii dihydropteroate synthase (DHPS; IC50 = 25 nM), an enzyme required for folate biosynthesis, in a cell-free assay.{38582} Sulfadimethoxine is active against S. aureus, S. pneumoniae, K. pneumoniae, and E. coli in a disc assay.{47622} It is also active against C. spiroforme isolates from rabbits (MIC90 = 256 μg/ml) and certain M. bovoculi isolates from keratoconjunctivitis infections in cows (MIC50 = ≤256 μg/ml).{46521,46522} Sulfadimethoxine is efficacious against S. pneumoniae, K. pneumoniae, and E. coli systemic infections in mice with 50% curative dose (CD50) values of 79.7, 2.7, and 12.2 mg/kg, respectively. It is also efficacious against H. capsulatum systemic fungal infections in mice (CD50 = 300 mg/kg).{47622}
Brand:CaymanSKU:28827 - 5 gAvailable on backorder
Sulfadimethoxine is a sulfonamide antibiotic that is active against Gram-negative and Gram-positive bacteria and other microorganisms.{47622} It inhibits recombinant P. carinii dihydropteroate synthase (DHPS; IC50 = 25 nM), an enzyme required for folate biosynthesis, in a cell-free assay.{38582} Sulfadimethoxine is active against S. aureus, S. pneumoniae, K. pneumoniae, and E. coli in a disc assay.{47622} It is also active against C. spiroforme isolates from rabbits (MIC90 = 256 μg/ml) and certain M. bovoculi isolates from keratoconjunctivitis infections in cows (MIC50 = ≤256 μg/ml).{46521,46522} Sulfadimethoxine is efficacious against S. pneumoniae, K. pneumoniae, and E. coli systemic infections in mice with 50% curative dose (CD50) values of 79.7, 2.7, and 12.2 mg/kg, respectively. It is also efficacious against H. capsulatum systemic fungal infections in mice (CD50 = 300 mg/kg).{47622}
Brand:CaymanSKU:28827 - 50 gAvailable on backorder
Sulfadoxin is a sulfonamide antibiotic that inhibits dihydropteroate synthetase (DHPS), an enzyme involved in folic acid (Item No. 20515) synthesis.{34630} Sulfadoxin competes with 4-aminobenzoate (PABA), the native substrate of DHPS, and inhibits PABA incorporation into folic acid.{34631} Folate is essential for purine and pyrimidine synthesis, therefore, sulfadoxin has antiproliferative activity in non-resistant P. falciparum.{34631,34632} Sulfadoxin inhibits growth of P. falciparum in vitro, but potency varies between non-resistant (IC50 = 4 ng/ml) and resistant strains (IC50 = 3,970 ng/ml).{34632}
Brand:CaymanSKU:21488 -Out of stock
Sulfadoxin is a sulfonamide antibiotic that inhibits dihydropteroate synthetase (DHPS), an enzyme involved in folic acid (Item No. 20515) synthesis.{34630} Sulfadoxin competes with 4-aminobenzoate (PABA), the native substrate of DHPS, and inhibits PABA incorporation into folic acid.{34631} Folate is essential for purine and pyrimidine synthesis, therefore, sulfadoxin has antiproliferative activity in non-resistant P. falciparum.{34631,34632} Sulfadoxin inhibits growth of P. falciparum in vitro, but potency varies between non-resistant (IC50 = 4 ng/ml) and resistant strains (IC50 = 3,970 ng/ml).{34632}
Brand:CaymanSKU:21488 -Out of stock
Sulfadoxin is a sulfonamide antibiotic that inhibits dihydropteroate synthetase (DHPS), an enzyme involved in folic acid (Item No. 20515) synthesis.{34630} Sulfadoxin competes with 4-aminobenzoate (PABA), the native substrate of DHPS, and inhibits PABA incorporation into folic acid.{34631} Folate is essential for purine and pyrimidine synthesis, therefore, sulfadoxin has antiproliferative activity in non-resistant P. falciparum.{34631,34632} Sulfadoxin inhibits growth of P. falciparum in vitro, but potency varies between non-resistant (IC50 = 4 ng/ml) and resistant strains (IC50 = 3,970 ng/ml).{34632}
Brand:CaymanSKU:21488 -Out of stock
Sulfadoxin is a sulfonamide antibiotic that inhibits dihydropteroate synthetase (DHPS), an enzyme involved in folic acid (Item No. 20515) synthesis.{34630} Sulfadoxin competes with 4-aminobenzoate (PABA), the native substrate of DHPS, and inhibits PABA incorporation into folic acid.{34631} Folate is essential for purine and pyrimidine synthesis, therefore, sulfadoxin has antiproliferative activity in non-resistant P. falciparum.{34631,34632} Sulfadoxin inhibits growth of P. falciparum in vitro, but potency varies between non-resistant (IC50 = 4 ng/ml) and resistant strains (IC50 = 3,970 ng/ml).{34632}
Brand:CaymanSKU:21488 -Out of stock
Sulfamerazine is a sulfonamide antibiotic.{38374} It inhibits bacterial carbonic anhydrase by ~20% at a concentration of 500 μM.{38376} In vivo, sulfamerazine (500 mg/L) reduces severity of peribronchitis and inhibits cilia-associated respiratory Bacillus colonization in mice.{38377} It also prevents death of Toxoplasma-infected mice.{38374} Sulfonamide class antibiotics, of which sulfamerazine is a member, are bacteriostatic and inhibit bacterial synthesis of dihydrofolic acid by competing with 4-aminobenzoic acid (Item No. 18659) for binding to dihydropteroate synthase.{38375} Formulations containing sulfamerazine have been used for the treatment of pneumonia and typhoid fever.{38378,38379}
Brand:CaymanSKU:23380 - 10 gAvailable on backorder
Sulfamerazine is a sulfonamide antibiotic.{38374} It inhibits bacterial carbonic anhydrase by ~20% at a concentration of 500 μM.{38376} In vivo, sulfamerazine (500 mg/L) reduces severity of peribronchitis and inhibits cilia-associated respiratory Bacillus colonization in mice.{38377} It also prevents death of Toxoplasma-infected mice.{38374} Sulfonamide class antibiotics, of which sulfamerazine is a member, are bacteriostatic and inhibit bacterial synthesis of dihydrofolic acid by competing with 4-aminobenzoic acid (Item No. 18659) for binding to dihydropteroate synthase.{38375} Formulations containing sulfamerazine have been used for the treatment of pneumonia and typhoid fever.{38378,38379}
Brand:CaymanSKU:23380 - 100 gAvailable on backorder
Sulfamerazine is a sulfonamide antibiotic.{38374} It inhibits bacterial carbonic anhydrase by ~20% at a concentration of 500 μM.{38376} In vivo, sulfamerazine (500 mg/L) reduces severity of peribronchitis and inhibits cilia-associated respiratory Bacillus colonization in mice.{38377} It also prevents death of Toxoplasma-infected mice.{38374} Sulfonamide class antibiotics, of which sulfamerazine is a member, are bacteriostatic and inhibit bacterial synthesis of dihydrofolic acid by competing with 4-aminobenzoic acid (Item No. 18659) for binding to dihydropteroate synthase.{38375} Formulations containing sulfamerazine have been used for the treatment of pneumonia and typhoid fever.{38378,38379}
Brand:CaymanSKU:23380 - 50 gAvailable on backorder
Sulfameter is a long-acting sulfonamide antibiotic.{47621} In vitro, it is active against the bacteria D. pneumoniae, K. pneumoniae, E. coli, N. meningitidis, P. vulgaris, S. aureus, S. haemolyticus, and S. typhimurium in a disc assay.{47622} Sulfameter is efficacious against lethal K. pneumoniae, E. coli, P. vulgaris, D. pneumoniae, P. aeruginosa, and S. typhimurium infection in a mouse model of septicemia with 50% curative dose (CD50) values of 1.6, 5.2, 5.4, 120.5, 19.1, and 88 mg/kg, respectively. Formulations containing sulfameter have previously been used in the treatment of urinary tract infections.
Brand:CaymanSKU:27630 - 10 gAvailable on backorder
Sulfameter is a long-acting sulfonamide antibiotic.{47621} In vitro, it is active against the bacteria D. pneumoniae, K. pneumoniae, E. coli, N. meningitidis, P. vulgaris, S. aureus, S. haemolyticus, and S. typhimurium in a disc assay.{47622} Sulfameter is efficacious against lethal K. pneumoniae, E. coli, P. vulgaris, D. pneumoniae, P. aeruginosa, and S. typhimurium infection in a mouse model of septicemia with 50% curative dose (CD50) values of 1.6, 5.2, 5.4, 120.5, 19.1, and 88 mg/kg, respectively. Formulations containing sulfameter have previously been used in the treatment of urinary tract infections.
Brand:CaymanSKU:27630 - 25 gAvailable on backorder
Sulfameter is a long-acting sulfonamide antibiotic.{47621} In vitro, it is active against the bacteria D. pneumoniae, K. pneumoniae, E. coli, N. meningitidis, P. vulgaris, S. aureus, S. haemolyticus, and S. typhimurium in a disc assay.{47622} Sulfameter is efficacious against lethal K. pneumoniae, E. coli, P. vulgaris, D. pneumoniae, P. aeruginosa, and S. typhimurium infection in a mouse model of septicemia with 50% curative dose (CD50) values of 1.6, 5.2, 5.4, 120.5, 19.1, and 88 mg/kg, respectively. Formulations containing sulfameter have previously been used in the treatment of urinary tract infections.
Brand:CaymanSKU:27630 - 5 gAvailable on backorder
Sulfameter is a long-acting sulfonamide antibiotic.{47621} In vitro, it is active against the bacteria D. pneumoniae, K. pneumoniae, E. coli, N. meningitidis, P. vulgaris, S. aureus, S. haemolyticus, and S. typhimurium in a disc assay.{47622} Sulfameter is efficacious against lethal K. pneumoniae, E. coli, P. vulgaris, D. pneumoniae, P. aeruginosa, and S. typhimurium infection in a mouse model of septicemia with 50% curative dose (CD50) values of 1.6, 5.2, 5.4, 120.5, 19.1, and 88 mg/kg, respectively. Formulations containing sulfameter have previously been used in the treatment of urinary tract infections.
Brand:CaymanSKU:27630 - 50 gAvailable on backorder
Sulfamethazine is an antibacterial sulfonamide. Like other sulfonamides, sulfamethazine is bacteriostatic, competitively inhibiting dihydropteroate synthase to block folate synthesis and inhibit growth and multiplication.{33013} Sulfamethazine is metabolized by cytochrome P450 isoforms and arylamine N-acetyltransferase 2 in a sex-dependent manner.{33014,33015,33017}
Brand:CaymanSKU:20976 -Out of stock
Sulfamethazine is an antibacterial sulfonamide. Like other sulfonamides, sulfamethazine is bacteriostatic, competitively inhibiting dihydropteroate synthase to block folate synthesis and inhibit growth and multiplication.{33013} Sulfamethazine is metabolized by cytochrome P450 isoforms and arylamine N-acetyltransferase 2 in a sex-dependent manner.{33014,33015,33017}
Brand:CaymanSKU:20976 -Out of stock
Sulfamethazine is an antibacterial sulfonamide. Like other sulfonamides, sulfamethazine is bacteriostatic, competitively inhibiting dihydropteroate synthase to block folate synthesis and inhibit growth and multiplication.{33013} Sulfamethazine is metabolized by cytochrome P450 isoforms and arylamine N-acetyltransferase 2 in a sex-dependent manner.{33014,33015,33017}
Brand:CaymanSKU:20976 -Out of stock
Sulfamethazine is an antibacterial sulfonamide. Like other sulfonamides, sulfamethazine is bacteriostatic, competitively inhibiting dihydropteroate synthase to block folate synthesis and inhibit growth and multiplication.{33013} Sulfamethazine is metabolized by cytochrome P450 isoforms and arylamine N-acetyltransferase 2 in a sex-dependent manner.{33014,33015,33017}
Brand:CaymanSKU:20976 -Out of stock
Sulfamethizole is a broad spectrum sulfonamide antibiotic (MIC90s = 1.25-5,000 μg/ml against clinical isolates of E. coli and K. pneumoniae).{40238} It inhibits dihydropteroate synthase, an enzyme involved in folate biosynthesis. Formulations containing sulfamethizole have previously been used to treat urinary tract infections.
Brand:CaymanSKU:23355 - 1 gAvailable on backorder
Sulfamethizole is a broad spectrum sulfonamide antibiotic (MIC90s = 1.25-5,000 μg/ml against clinical isolates of E. coli and K. pneumoniae).{40238} It inhibits dihydropteroate synthase, an enzyme involved in folate biosynthesis. Formulations containing sulfamethizole have previously been used to treat urinary tract infections.
Brand:CaymanSKU:23355 - 250 mgAvailable on backorder
Sulfamethizole is a broad spectrum sulfonamide antibiotic (MIC90s = 1.25-5,000 μg/ml against clinical isolates of E. coli and K. pneumoniae).{40238} It inhibits dihydropteroate synthase, an enzyme involved in folate biosynthesis. Formulations containing sulfamethizole have previously been used to treat urinary tract infections.
Brand:CaymanSKU:23355 - 5 gAvailable on backorder
Sulfamethizole is a broad spectrum sulfonamide antibiotic (MIC90s = 1.25-5,000 μg/ml against clinical isolates of E. coli and K. pneumoniae).{40238} It inhibits dihydropteroate synthase, an enzyme involved in folate biosynthesis. Formulations containing sulfamethizole have previously been used to treat urinary tract infections.
Brand:CaymanSKU:23355 - 500 mgAvailable on backorder
Sulfamethoxazole is a sulfonamide antibiotic.{38582} It inhibits growth of E. coli (MIC = 10 μg/ml) and clinical isolates of methicillin-resistant S. aureus (MRSA; MICs = 25-50 μg/ml).{38583,38584} Sulfamethoxazole, in combination with trimethoprim (Item No. 16473) at a ratio of 20:1, inhibits growth of MRSA in vivo in mice (MIC = 0.8 μg/ml; ED50s = 6.4 and 9.6 mg/kg for two MRSA strains).{38584} In a mouse model of urinary tract infection with E. coli, a combination of sulfamethoxazole and trimethoprim decreases recurrent infection when administered for 10 days.{38585} Sulfamethoxazole acts by inhibiting dihydropteroate synthase (DHPS), which converts a pteridine and 4-aminobenzoic acid (PABA; Item No. 18659) to dihydropteroate, an intermediate in folate biosynthesis. It inhibits recombinant P. carinii DHPS (IC50 = 23 nM; Ki = 7.5 nM) and folate biosynthesis in situ by 48.6%. Formulations containing sulfamethoxazole and trimethoprim have been used to treat bronchitis, prostatitis, and urinary tract infections among other infectious conditions.
Brand:CaymanSKU:23613 - 100 gAvailable on backorder
Sulfamethoxazole is a sulfonamide antibiotic.{38582} It inhibits growth of E. coli (MIC = 10 μg/ml) and clinical isolates of methicillin-resistant S. aureus (MRSA; MICs = 25-50 μg/ml).{38583,38584} Sulfamethoxazole, in combination with trimethoprim (Item No. 16473) at a ratio of 20:1, inhibits growth of MRSA in vivo in mice (MIC = 0.8 μg/ml; ED50s = 6.4 and 9.6 mg/kg for two MRSA strains).{38584} In a mouse model of urinary tract infection with E. coli, a combination of sulfamethoxazole and trimethoprim decreases recurrent infection when administered for 10 days.{38585} Sulfamethoxazole acts by inhibiting dihydropteroate synthase (DHPS), which converts a pteridine and 4-aminobenzoic acid (PABA; Item No. 18659) to dihydropteroate, an intermediate in folate biosynthesis. It inhibits recombinant P. carinii DHPS (IC50 = 23 nM; Ki = 7.5 nM) and folate biosynthesis in situ by 48.6%. Formulations containing sulfamethoxazole and trimethoprim have been used to treat bronchitis, prostatitis, and urinary tract infections among other infectious conditions.
Brand:CaymanSKU:23613 - 25 gAvailable on backorder
Sulfamethoxazole is a sulfonamide antibiotic.{38582} It inhibits growth of E. coli (MIC = 10 μg/ml) and clinical isolates of methicillin-resistant S. aureus (MRSA; MICs = 25-50 μg/ml).{38583,38584} Sulfamethoxazole, in combination with trimethoprim (Item No. 16473) at a ratio of 20:1, inhibits growth of MRSA in vivo in mice (MIC = 0.8 μg/ml; ED50s = 6.4 and 9.6 mg/kg for two MRSA strains).{38584} In a mouse model of urinary tract infection with E. coli, a combination of sulfamethoxazole and trimethoprim decreases recurrent infection when administered for 10 days.{38585} Sulfamethoxazole acts by inhibiting dihydropteroate synthase (DHPS), which converts a pteridine and 4-aminobenzoic acid (PABA; Item No. 18659) to dihydropteroate, an intermediate in folate biosynthesis. It inhibits recombinant P. carinii DHPS (IC50 = 23 nM; Ki = 7.5 nM) and folate biosynthesis in situ by 48.6%. Formulations containing sulfamethoxazole and trimethoprim have been used to treat bronchitis, prostatitis, and urinary tract infections among other infectious conditions.
Brand:CaymanSKU:23613 - 50 gAvailable on backorder
Sulfamethoxazole-d4 is intended for use as an internal standard for the quantification of sulfamethoxazole (Item No. 23613) by GC- or LC-MS. Sulfamethoxazole is a sulfonamide antibiotic.{38582} It inhibits growth of E. coli (MIC = 10 μg/ml) and clinical isolates of methicillin-resistant S. aureus (MRSA; MICs = 25-50 μg/ml).{38583,38584} Sulfamethoxazole, in combination with trimethoprim (Item No. 16473) at a ratio of 20:1, inhibits growth of MRSA in vivo in mice (MIC = 0.8 μg/ml; ED50s = 6.4 and 9.6 mg/kg for two MRSA strains).{38584} In a mouse model of urinary tract infection with E. coli, a combination of sulfamethoxazole and trimethoprim decreases recurrent infection when administered for 10 days.{38585} Sulfamethoxazole acts by inhibiting dihydropteroate synthase (DHPS), which converts pteridine and 4-aminobenzoic acid (PABA; Item No. 18659) to dihydropteroate, an intermediate in folate biosynthesis. It inhibits recombinant P. carinii DHPS (IC50 = 23 nM; Ki = 7.5 nM) and folate biosynthesis in situ by 48.6%. Formulations containing sulfamethoxazole and trimethoprim have been used to treat bronchitis, prostatitis, and urinary tract infections among other infectious conditions.
Brand:CaymanSKU:28618 - 1 mgAvailable on backorder
Sulfamethoxazole-d4 is intended for use as an internal standard for the quantification of sulfamethoxazole (Item No. 23613) by GC- or LC-MS. Sulfamethoxazole is a sulfonamide antibiotic.{38582} It inhibits growth of E. coli (MIC = 10 μg/ml) and clinical isolates of methicillin-resistant S. aureus (MRSA; MICs = 25-50 μg/ml).{38583,38584} Sulfamethoxazole, in combination with trimethoprim (Item No. 16473) at a ratio of 20:1, inhibits growth of MRSA in vivo in mice (MIC = 0.8 μg/ml; ED50s = 6.4 and 9.6 mg/kg for two MRSA strains).{38584} In a mouse model of urinary tract infection with E. coli, a combination of sulfamethoxazole and trimethoprim decreases recurrent infection when administered for 10 days.{38585} Sulfamethoxazole acts by inhibiting dihydropteroate synthase (DHPS), which converts pteridine and 4-aminobenzoic acid (PABA; Item No. 18659) to dihydropteroate, an intermediate in folate biosynthesis. It inhibits recombinant P. carinii DHPS (IC50 = 23 nM; Ki = 7.5 nM) and folate biosynthesis in situ by 48.6%. Formulations containing sulfamethoxazole and trimethoprim have been used to treat bronchitis, prostatitis, and urinary tract infections among other infectious conditions.
Brand:CaymanSKU:28618 - 10 mgAvailable on backorder
Sulfamethoxazole-d4 is intended for use as an internal standard for the quantification of sulfamethoxazole (Item No. 23613) by GC- or LC-MS. Sulfamethoxazole is a sulfonamide antibiotic.{38582} It inhibits growth of E. coli (MIC = 10 μg/ml) and clinical isolates of methicillin-resistant S. aureus (MRSA; MICs = 25-50 μg/ml).{38583,38584} Sulfamethoxazole, in combination with trimethoprim (Item No. 16473) at a ratio of 20:1, inhibits growth of MRSA in vivo in mice (MIC = 0.8 μg/ml; ED50s = 6.4 and 9.6 mg/kg for two MRSA strains).{38584} In a mouse model of urinary tract infection with E. coli, a combination of sulfamethoxazole and trimethoprim decreases recurrent infection when administered for 10 days.{38585} Sulfamethoxazole acts by inhibiting dihydropteroate synthase (DHPS), which converts pteridine and 4-aminobenzoic acid (PABA; Item No. 18659) to dihydropteroate, an intermediate in folate biosynthesis. It inhibits recombinant P. carinii DHPS (IC50 = 23 nM; Ki = 7.5 nM) and folate biosynthesis in situ by 48.6%. Formulations containing sulfamethoxazole and trimethoprim have been used to treat bronchitis, prostatitis, and urinary tract infections among other infectious conditions.
Brand:CaymanSKU:28618 - 25 mgAvailable on backorder
Sulfamethoxazole-d4 is intended for use as an internal standard for the quantification of sulfamethoxazole (Item No. 23613) by GC- or LC-MS. Sulfamethoxazole is a sulfonamide antibiotic.{38582} It inhibits growth of E. coli (MIC = 10 μg/ml) and clinical isolates of methicillin-resistant S. aureus (MRSA; MICs = 25-50 μg/ml).{38583,38584} Sulfamethoxazole, in combination with trimethoprim (Item No. 16473) at a ratio of 20:1, inhibits growth of MRSA in vivo in mice (MIC = 0.8 μg/ml; ED50s = 6.4 and 9.6 mg/kg for two MRSA strains).{38584} In a mouse model of urinary tract infection with E. coli, a combination of sulfamethoxazole and trimethoprim decreases recurrent infection when administered for 10 days.{38585} Sulfamethoxazole acts by inhibiting dihydropteroate synthase (DHPS), which converts pteridine and 4-aminobenzoic acid (PABA; Item No. 18659) to dihydropteroate, an intermediate in folate biosynthesis. It inhibits recombinant P. carinii DHPS (IC50 = 23 nM; Ki = 7.5 nM) and folate biosynthesis in situ by 48.6%. Formulations containing sulfamethoxazole and trimethoprim have been used to treat bronchitis, prostatitis, and urinary tract infections among other infectious conditions.
Brand:CaymanSKU:28618 - 5 mgAvailable on backorder