Cayman
Showing 40351–40500 of 45550 results
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ST1535 is an adenosine A2A receptor antagonist.{58030} It is selective for adenosine A2A over A1 receptors (Kis = 2.3 and 107 nM, respectively, in radioligand binding assays). ST1535 inhibits agonist-induced production of cAMP in CHO cells expressing adenosine A2A receptors (IC50 = 353 nM). In vivo, ST1535 (10 and 20 mg/kg) reduces haloperidol-induced catalepsy in mice. It reduces the number of jaw tremors in a rat model of Parkinsonian jaw tremors induced by tacrine (Item No. 70240).{58031} ST1535 (20 and 40 mg/kg) increases locomotor activity and reverses motor disabilities in a marmoset model of MPTP-induced Parkinson’s disease.{58032}
Brand:CaymanSKU:10611 - 10 mgAvailable on backorder
ST1535 is an adenosine A2A receptor antagonist.{58030} It is selective for adenosine A2A over A1 receptors (Kis = 2.3 and 107 nM, respectively, in radioligand binding assays). ST1535 inhibits agonist-induced production of cAMP in CHO cells expressing adenosine A2A receptors (IC50 = 353 nM). In vivo, ST1535 (10 and 20 mg/kg) reduces haloperidol-induced catalepsy in mice. It reduces the number of jaw tremors in a rat model of Parkinsonian jaw tremors induced by tacrine (Item No. 70240).{58031} ST1535 (20 and 40 mg/kg) increases locomotor activity and reverses motor disabilities in a marmoset model of MPTP-induced Parkinson’s disease.{58032}
Brand:CaymanSKU:10611 - 25 mgAvailable on backorder
ST1535 is an adenosine A2A receptor antagonist.{58030} It is selective for adenosine A2A over A1 receptors (Kis = 2.3 and 107 nM, respectively, in radioligand binding assays). ST1535 inhibits agonist-induced production of cAMP in CHO cells expressing adenosine A2A receptors (IC50 = 353 nM). In vivo, ST1535 (10 and 20 mg/kg) reduces haloperidol-induced catalepsy in mice. It reduces the number of jaw tremors in a rat model of Parkinsonian jaw tremors induced by tacrine (Item No. 70240).{58031} ST1535 (20 and 40 mg/kg) increases locomotor activity and reverses motor disabilities in a marmoset model of MPTP-induced Parkinson’s disease.{58032}
Brand:CaymanSKU:10611 - 5 mgAvailable on backorder
ST1535 is an adenosine A2A receptor antagonist.{58030} It is selective for adenosine A2A over A1 receptors (Kis = 2.3 and 107 nM, respectively, in radioligand binding assays). ST1535 inhibits agonist-induced production of cAMP in CHO cells expressing adenosine A2A receptors (IC50 = 353 nM). In vivo, ST1535 (10 and 20 mg/kg) reduces haloperidol-induced catalepsy in mice. It reduces the number of jaw tremors in a rat model of Parkinsonian jaw tremors induced by tacrine (Item No. 70240).{58031} ST1535 (20 and 40 mg/kg) increases locomotor activity and reverses motor disabilities in a marmoset model of MPTP-induced Parkinson’s disease.{58032}
Brand:CaymanSKU:10611 - 50 mgAvailable on backorder
ST638 is a tyrosine kinase inhibitor (IC50 = 370 nM). It suppresses tyrosine phosphorylation induced by tumor necrosis factor-α and phorbol myristate acetate in neutrophils and by angiotensin II in cardiac fibroblasts.{18435,18436,18437}
Brand:CaymanSKU:- ST638 is a tyrosine kinase inhibitor (IC50 = 370 nM). It suppresses tyrosine phosphorylation induced by tumor necrosis factor-α and phorbol myristate acetate in neutrophils and by angiotensin II in cardiac fibroblasts.{18435,18436,18437}
Brand:CaymanSKU:- ST638 is a tyrosine kinase inhibitor (IC50 = 370 nM). It suppresses tyrosine phosphorylation induced by tumor necrosis factor-α and phorbol myristate acetate in neutrophils and by angiotensin II in cardiac fibroblasts.{18435,18436,18437}
Brand:CaymanSKU:- ST638 is a tyrosine kinase inhibitor (IC50 = 370 nM). It suppresses tyrosine phosphorylation induced by tumor necrosis factor-α and phorbol myristate acetate in neutrophils and by angiotensin II in cardiac fibroblasts.{18435,18436,18437}
Brand:CaymanSKU:-
STA-21 is a natural antibiotic that potently inhibits STAT3 by preventing its dimerization and DNA binding when used at concentrations of 20-30 μM.{24347} It blocks the growth and survival of cancer cells that express constitutively active STAT3 (e.g., DU145 cells, IC50 = 12.2 μM).{24347,24349,24348} STAT3 inhibitors, including STA-21, prevent the proliferation of human keratinocytes and have value in improving psoriasis.{24350}
Brand:CaymanSKU:- STA-21 is a natural antibiotic that potently inhibits STAT3 by preventing its dimerization and DNA binding when used at concentrations of 20-30 μM.{24347} It blocks the growth and survival of cancer cells that express constitutively active STAT3 (e.g., DU145 cells, IC50 = 12.2 μM).{24347,24349,24348} STAT3 inhibitors, including STA-21, prevent the proliferation of human keratinocytes and have value in improving psoriasis.{24350}
Brand:CaymanSKU:- STA-21 is a natural antibiotic that potently inhibits STAT3 by preventing its dimerization and DNA binding when used at concentrations of 20-30 μM.{24347} It blocks the growth and survival of cancer cells that express constitutively active STAT3 (e.g., DU145 cells, IC50 = 12.2 μM).{24347,24349,24348} STAT3 inhibitors, including STA-21, prevent the proliferation of human keratinocytes and have value in improving psoriasis.{24350}
Brand:CaymanSKU:-
StA-IFN-1 is an inhibitor of the interferon (IFN) induction pathway with an IC50 value of 4.1 µM in a GFP reporter assay for IFN induction similar to TPCA-1 (Item No. 15115), which specifically inhibits the IKKβ component of the IFN induction pathway.{37091} It does not show inhibitory activity in a GFP reporter assay for IFN signaling in which ruxolitinib (Item No. 11609), which is specific for the IFN signaling component JAK1, is active. StA-IFN-1 reduces the levels of IFN-β, but not ISG MxA, mRNA, suggesting that it is selective for the IFN induction pathway and not the IFN signaling pathway.
Brand:CaymanSKU:22402 -Out of stock
StA-IFN-1 is an inhibitor of the interferon (IFN) induction pathway with an IC50 value of 4.1 µM in a GFP reporter assay for IFN induction similar to TPCA-1 (Item No. 15115), which specifically inhibits the IKKβ component of the IFN induction pathway.{37091} It does not show inhibitory activity in a GFP reporter assay for IFN signaling in which ruxolitinib (Item No. 11609), which is specific for the IFN signaling component JAK1, is active. StA-IFN-1 reduces the levels of IFN-β, but not ISG MxA, mRNA, suggesting that it is selective for the IFN induction pathway and not the IFN signaling pathway.
Brand:CaymanSKU:22402 -Out of stock
StA-IFN-1 is an inhibitor of the interferon (IFN) induction pathway with an IC50 value of 4.1 µM in a GFP reporter assay for IFN induction similar to TPCA-1 (Item No. 15115), which specifically inhibits the IKKβ component of the IFN induction pathway.{37091} It does not show inhibitory activity in a GFP reporter assay for IFN signaling in which ruxolitinib (Item No. 11609), which is specific for the IFN signaling component JAK1, is active. StA-IFN-1 reduces the levels of IFN-β, but not ISG MxA, mRNA, suggesting that it is selective for the IFN induction pathway and not the IFN signaling pathway.
Brand:CaymanSKU:22402 -Out of stock
Stachybotrylactam is a spirodihydrobenzofuranlactam mycotoxin originally isolated from Stachybotrys with antiviral activity.{39040,39041} It inhibits HIV-1 protease in vitro with an IC50 value of 161 μM.{39041} Stachybotrylactam has no effect on oleic acid-elicited intracellular lipid accumulation and has no observable cytotoxicity at concentrations up to 100 μM in HepG2 cells.{39042}
Brand:CaymanSKU:22584 -Out of stock
Stachybotrylactam is a spirodihydrobenzofuranlactam mycotoxin originally isolated from Stachybotrys with antiviral activity.{39040,39041} It inhibits HIV-1 protease in vitro with an IC50 value of 161 μM.{39041} Stachybotrylactam has no effect on oleic acid-elicited intracellular lipid accumulation and has no observable cytotoxicity at concentrations up to 100 μM in HepG2 cells.{39042}
Brand:CaymanSKU:22584 -Out of stock
Stachybotrysin B is a fungal metabolite originally isolated from S. chartarum and has antiviral and anticancer activities.{48722,48723} It has antiviral activity against HIV in SupT1 cells (IC50 = 19.2 μM).{48722} Stachybotrysin B is cytotoxic to K562, HeLa, and HL-60 cells (IC50s = 21.72, 39.63, and 18.5 μM, respectively).{48723}
Brand:CaymanSKU:29583 - 1 mgAvailable on backorder
Brand:CaymanSKU:700732 - 12 mlAvailable on backorder
Brand:CaymanSKU:700732 - 4 mlAvailable on backorder
Brand:CaymanSKU:400432 - 100 dtnAvailable on backorder
Brand:CaymanSKU:400432 - 500 dtnAvailable on backorder
The isoprostanes are a family of eicosanoids of non-enzymatic origin produced by the random oxidation of tissue phospholipids by oxygen radicals. At least one of the isoprostanes, 8-isoprostane (8-iso PGF2α), has biological activity and has implicated as a causative mediator and specific marker of free radical-induced damage in a variety of diseases related to oxidative stress.{1053,1381,9138,9117} Cayman Chemical’s STAT-8-isoprostane ELISA is a competitive assay that permits the rapid measurement of 8-iso PGF2α from biological samples, requiring only 1 hour incubation and development times for each step. This assay format is the similar to that employed in Cayman’s popular 8-isoprostane ELISA (Item No. 516351) with the only change being the use of an alkaline phosphatase tracer in place of an AChE tracer. While Item No. 516351 offers superior sensitivity (IC50 ~35 pg/ml), the new STAT-8-isoprostane Assay offers the convenience of a fast assay while still achieving an IC50 of 180 pg/ml and a detection limit (80% B/B0) of approximately 45 pg/ml.
Brand:CaymanSKU:500431 - 480 solid wellsAvailable on backorder
The isoprostanes are a family of eicosanoids of non-enzymatic origin produced by the random oxidation of tissue phospholipids by oxygen radicals. At least one of the isoprostanes, 8-isoprostane (8-iso PGF2α), has biological activity and has implicated as a causative mediator and specific marker of free radical-induced damage in a variety of diseases related to oxidative stress.{1053,1381,9138,9117} Cayman Chemical’s STAT-8-isoprostane ELISA is a competitive assay that permits the rapid measurement of 8-iso PGF2α from biological samples, requiring only 1 hour incubation and development times for each step. This assay format is the similar to that employed in Cayman’s popular 8-isoprostane ELISA (Item No. 516351) with the only change being the use of an alkaline phosphatase tracer in place of an AChE tracer. While Item No. 516351 offers superior sensitivity (IC50 ~35 pg/ml), the new STAT-8-isoprostane Assay offers the convenience of a fast assay while still achieving an IC50 of 180 pg/ml and a detection limit (80% B/B0) of approximately 45 pg/ml.
Brand:CaymanSKU:500431 - 480 strip wellsAvailable on backorder
The isoprostanes are a family of eicosanoids of non-enzymatic origin produced by the random oxidation of tissue phospholipids by oxygen radicals. At least one of the isoprostanes, 8-isoprostane (8-iso PGF2α), has biological activity and has implicated as a causative mediator and specific marker of free radical-induced damage in a variety of diseases related to oxidative stress.{1053,1381,9138,9117} Cayman Chemical’s STAT-8-isoprostane ELISA is a competitive assay that permits the rapid measurement of 8-iso PGF2α from biological samples, requiring only 1 hour incubation and development times for each step. This assay format is the similar to that employed in Cayman’s popular 8-isoprostane ELISA (Item No. 516351) with the only change being the use of an alkaline phosphatase tracer in place of an AChE tracer. While Item No. 516351 offers superior sensitivity (IC50 ~35 pg/ml), the new STAT-8-isoprostane Assay offers the convenience of a fast assay while still achieving an IC50 of 180 pg/ml and a detection limit (80% B/B0) of approximately 45 pg/ml.
Brand:CaymanSKU:500431 - 96 solid wellsAvailable on backorder
The isoprostanes are a family of eicosanoids of non-enzymatic origin produced by the random oxidation of tissue phospholipids by oxygen radicals. At least one of the isoprostanes, 8-isoprostane (8-iso PGF2α), has biological activity and has implicated as a causative mediator and specific marker of free radical-induced damage in a variety of diseases related to oxidative stress.{1053,1381,9138,9117} Cayman Chemical’s STAT-8-isoprostane ELISA is a competitive assay that permits the rapid measurement of 8-iso PGF2α from biological samples, requiring only 1 hour incubation and development times for each step. This assay format is the similar to that employed in Cayman’s popular 8-isoprostane ELISA (Item No. 516351) with the only change being the use of an alkaline phosphatase tracer in place of an AChE tracer. While Item No. 516351 offers superior sensitivity (IC50 ~35 pg/ml), the new STAT-8-isoprostane Assay offers the convenience of a fast assay while still achieving an IC50 of 180 pg/ml and a detection limit (80% B/B0) of approximately 45 pg/ml.
Brand:CaymanSKU:500431 - 96 strip wellsAvailable on backorder
Brand:CaymanSKU:400434 - 1 eaAvailable on backorder
Cayman’s STAT3 Transcription Factor Assay Kit is a non-radioactive, sensitive method for detecting specific STAT3 DNA binding activity in nuclear extracts. As an alternative to the cumbersome electrophoretic mobility shift assay (EMSA) or the lower throughput ChIP assay, this ELISA is extremely easy to perform. This kit is an ideal way to measure STAT3 transcriptional activity downstream of cytokine or drug treatment and manipulation of cells in vitro or in vivo. Cayman’s STAT3 Transcription Factor Assay Kit detects human, mouse, rat, and non-human primate STAT3 binding on the DNA target sequence. It does not cross react with other STAT transcription factors.
Brand:CaymanSKU:601950 - 96 wellsAvailable on backorder
Signal Transducers and Activators of Transcriptions (STATs) are a family of cytoplasmic latent transcription factors that are activated to regulate gene expression in response to a large number of extracellular signaling polypeptides including cytokines, interferons, and growth factors.{19346,19347,5047} STAT5, which consists of two isoforms STAT5α and STAT5β, is known to be overactive in several kinds of leukemias and various solid tumors. STAT5 Inhibitor is a cell-permeable, nonpetidic nicotinoyl hydrazone that suppresses STAT5 by targeting its SH2 domain (IC50 = 47 µM against STAT5β SH2 domain EPO peptide binding activity).{25879} Comparatively, this compound exhibits reduced potency towards inhibiting the SH2 domain of STAT1, STAT3, or Lck (IC50 > 500 µM).{25879} STAT5 Inhibitor has been shown to block STAT5/STAT5 DNA binding in K562 nuclear extracts.{25879}
Brand:CaymanSKU:- Signal Transducers and Activators of Transcriptions (STATs) are a family of cytoplasmic latent transcription factors that are activated to regulate gene expression in response to a large number of extracellular signaling polypeptides including cytokines, interferons, and growth factors.{19346,19347,5047} STAT5, which consists of two isoforms STAT5α and STAT5β, is known to be overactive in several kinds of leukemias and various solid tumors. STAT5 Inhibitor is a cell-permeable, nonpetidic nicotinoyl hydrazone that suppresses STAT5 by targeting its SH2 domain (IC50 = 47 µM against STAT5β SH2 domain EPO peptide binding activity).{25879} Comparatively, this compound exhibits reduced potency towards inhibiting the SH2 domain of STAT1, STAT3, or Lck (IC50 > 500 µM).{25879} STAT5 Inhibitor has been shown to block STAT5/STAT5 DNA binding in K562 nuclear extracts.{25879}
Brand:CaymanSKU:- Signal Transducers and Activators of Transcriptions (STATs) are a family of cytoplasmic latent transcription factors that are activated to regulate gene expression in response to a large number of extracellular signaling polypeptides including cytokines, interferons, and growth factors.{19346,19347,5047} STAT5, which consists of two isoforms STAT5α and STAT5β, is known to be overactive in several kinds of leukemias and various solid tumors. STAT5 Inhibitor is a cell-permeable, nonpetidic nicotinoyl hydrazone that suppresses STAT5 by targeting its SH2 domain (IC50 = 47 µM against STAT5β SH2 domain EPO peptide binding activity).{25879} Comparatively, this compound exhibits reduced potency towards inhibiting the SH2 domain of STAT1, STAT3, or Lck (IC50 > 500 µM).{25879} STAT5 Inhibitor has been shown to block STAT5/STAT5 DNA binding in K562 nuclear extracts.{25879}
Brand:CaymanSKU:-
Statil is an aldose reductase inhibitor that blocks the conversion of glucose to sorbitol. It demonstrates selectivity for aldose reductase 2 over aldose reductase 1 with Ki values of 7.7 nM and 60 µM, respectively.{31161} Statil has been shown to prevent diabetes-induced alterations of the cardiovascular system in 14-day streptozotocin-diabetic rats.{31160} Aldose reductase inhibition by statil has also been used to impair the synthesis of prostaglandin F2α by human cultured preadipocytes.{31159}
Brand:CaymanSKU:-Available on backorder
Statil is an aldose reductase inhibitor that blocks the conversion of glucose to sorbitol. It demonstrates selectivity for aldose reductase 2 over aldose reductase 1 with Ki values of 7.7 nM and 60 µM, respectively.{31161} Statil has been shown to prevent diabetes-induced alterations of the cardiovascular system in 14-day streptozotocin-diabetic rats.{31160} Aldose reductase inhibition by statil has also been used to impair the synthesis of prostaglandin F2α by human cultured preadipocytes.{31159}
Brand:CaymanSKU:-Available on backorder
Statil is an aldose reductase inhibitor that blocks the conversion of glucose to sorbitol. It demonstrates selectivity for aldose reductase 2 over aldose reductase 1 with Ki values of 7.7 nM and 60 µM, respectively.{31161} Statil has been shown to prevent diabetes-induced alterations of the cardiovascular system in 14-day streptozotocin-diabetic rats.{31160} Aldose reductase inhibition by statil has also been used to impair the synthesis of prostaglandin F2α by human cultured preadipocytes.{31159}
Brand:CaymanSKU:-Available on backorder
Statil is an aldose reductase inhibitor that blocks the conversion of glucose to sorbitol. It demonstrates selectivity for aldose reductase 2 over aldose reductase 1 with Ki values of 7.7 nM and 60 µM, respectively.{31161} Statil has been shown to prevent diabetes-induced alterations of the cardiovascular system in 14-day streptozotocin-diabetic rats.{31160} Aldose reductase inhibition by statil has also been used to impair the synthesis of prostaglandin F2α by human cultured preadipocytes.{31159}
Brand:CaymanSKU:-Available on backorder
Signal transducers and activators of transcription (STATs) are a family of latent cytoplasmic transcription factors that convey signals from the cell membrane to the nucleus. In various human tumors, STAT3 is constitutively activated by aberrant upstream tyrosine kinase activities.{23053} Stattic is a small molecule inhibitor of STAT3.{23053} It selectively inhibits STAT3 activation, dimerization, and nuclear translocation by preventing the binding of tyrosine-phosphorylated peptide motifs to the STAT3 SH2 domain (IC50 = 5.1 μM at 37°C).{23053} At 10 μM, stattic induces apoptosis in STAT3-dependent breast cancer (MDA-MB-231 and MDA-MB-435S) cell lines.{23053}
Brand:CaymanSKU:- Signal transducers and activators of transcription (STATs) are a family of latent cytoplasmic transcription factors that convey signals from the cell membrane to the nucleus. In various human tumors, STAT3 is constitutively activated by aberrant upstream tyrosine kinase activities.{23053} Stattic is a small molecule inhibitor of STAT3.{23053} It selectively inhibits STAT3 activation, dimerization, and nuclear translocation by preventing the binding of tyrosine-phosphorylated peptide motifs to the STAT3 SH2 domain (IC50 = 5.1 μM at 37°C).{23053} At 10 μM, stattic induces apoptosis in STAT3-dependent breast cancer (MDA-MB-231 and MDA-MB-435S) cell lines.{23053}
Brand:CaymanSKU:- Signal transducers and activators of transcription (STATs) are a family of latent cytoplasmic transcription factors that convey signals from the cell membrane to the nucleus. In various human tumors, STAT3 is constitutively activated by aberrant upstream tyrosine kinase activities.{23053} Stattic is a small molecule inhibitor of STAT3.{23053} It selectively inhibits STAT3 activation, dimerization, and nuclear translocation by preventing the binding of tyrosine-phosphorylated peptide motifs to the STAT3 SH2 domain (IC50 = 5.1 μM at 37°C).{23053} At 10 μM, stattic induces apoptosis in STAT3-dependent breast cancer (MDA-MB-231 and MDA-MB-435S) cell lines.{23053}
Brand:CaymanSKU:-
Stauprimide is a small molecule that increases the efficiency of mouse and human embryonic stem cell differentiation in conjunction with lineage specification cues (EC50 = 0.3 μM).{24988} It specifically inhibits the nuclear localization of NME2, which results in the suppression of c-Myc, a key regulator of pluripotency.{24988}
Brand:CaymanSKU:- Stauprimide is a small molecule that increases the efficiency of mouse and human embryonic stem cell differentiation in conjunction with lineage specification cues (EC50 = 0.3 μM).{24988} It specifically inhibits the nuclear localization of NME2, which results in the suppression of c-Myc, a key regulator of pluripotency.{24988}
Brand:CaymanSKU:- Stauprimide is a small molecule that increases the efficiency of mouse and human embryonic stem cell differentiation in conjunction with lineage specification cues (EC50 = 0.3 μM).{24988} It specifically inhibits the nuclear localization of NME2, which results in the suppression of c-Myc, a key regulator of pluripotency.{24988}
Brand:CaymanSKU:-
Staurosporine (Stsp) is potent inhibitor of protein kinase C (PKC) from rat brain, exhibiting an IC50 value of 2.7 nM.{9054} It inhibits rat recombinant PKC-α approximately 100- and 1,000-fold better than PKC-δ and PKC-ζ, respectively.{9107} However, Stsp is non-selective in that it also inhibits the activity of a variety of other protein kinases, not only PKC isoforms.{9106} The biological effects of Stsp include cytotoxicity, relaxation of smooth muscle, and regulation of eNOS gene expression.{9106,8207}
Brand:CaymanSKU:81590 - 1 mgAvailable on backorder
Staurosporine (Stsp) is potent inhibitor of protein kinase C (PKC) from rat brain, exhibiting an IC50 value of 2.7 nM.{9054} It inhibits rat recombinant PKC-α approximately 100- and 1,000-fold better than PKC-δ and PKC-ζ, respectively.{9107} However, Stsp is non-selective in that it also inhibits the activity of a variety of other protein kinases, not only PKC isoforms.{9106} The biological effects of Stsp include cytotoxicity, relaxation of smooth muscle, and regulation of eNOS gene expression.{9106,8207}
Brand:CaymanSKU:81590 - 10 mgAvailable on backorder
Staurosporine (Stsp) is potent inhibitor of protein kinase C (PKC) from rat brain, exhibiting an IC50 value of 2.7 nM.{9054} It inhibits rat recombinant PKC-α approximately 100- and 1,000-fold better than PKC-δ and PKC-ζ, respectively.{9107} However, Stsp is non-selective in that it also inhibits the activity of a variety of other protein kinases, not only PKC isoforms.{9106} The biological effects of Stsp include cytotoxicity, relaxation of smooth muscle, and regulation of eNOS gene expression.{9106,8207}
Brand:CaymanSKU:81590 - 5 mgAvailable on backorder
Staurosporine (Stsp) is potent inhibitor of protein kinase C (PKC) from rat brain, exhibiting an IC50 value of 2.7 nM.{9054} It inhibits rat recombinant PKC-α approximately 100- and 1,000-fold better than PKC-δ and PKC-ζ, respectively.{9107} However, Stsp is non-selective in that it also inhibits the activity of a variety of other protein kinases, not only PKC isoforms.{9106} The biological effects of Stsp include cytotoxicity, relaxation of smooth muscle, and regulation of eNOS gene expression.{9106,8207}
Brand:CaymanSKU:81590 - 500 µgAvailable on backorder
Stavudine is an inhibitor of HIV reverse transcriptase and a derivative of the nucleoside thymidine (Item No. 20519).{53215} It inhibits HIV-1 replication in human peripheral blood mononuclear cells (PBMCs; EC50 = 8.8 nM). Stavudine reduces the synthesis of HIV-specific antigen in MT-4 cells when used at concentrations ranging from 0.1 to 10 µg/ml and reduces HIV-induced plaque formation in MT-4 cells at 0.05 µg/ml.{29420} It reduces plasma- and cell-associated viral load in macaques infected with a highly pathogenic isolate of HIV-2.{53216} Stavudine induces sustained hind paw mechanical allodynia in a rat model of antiretroviral toxic neuropathy (ATN) when administered at a dose of 75 mg/kg twice weekly for five consecutive doses for a cumulative dose of 375 mg/kg.{53217} Formulations containing stavudine, in combination with other antiretrovirals, have been used in the treatment of HIV-1 infection.
Brand:CaymanSKU:- Stavudine is an inhibitor of HIV reverse transcriptase and a derivative of the nucleoside thymidine (Item No. 20519).{53215} It inhibits HIV-1 replication in human peripheral blood mononuclear cells (PBMCs; EC50 = 8.8 nM). Stavudine reduces the synthesis of HIV-specific antigen in MT-4 cells when used at concentrations ranging from 0.1 to 10 µg/ml and reduces HIV-induced plaque formation in MT-4 cells at 0.05 µg/ml.{29420} It reduces plasma- and cell-associated viral load in macaques infected with a highly pathogenic isolate of HIV-2.{53216} Stavudine induces sustained hind paw mechanical allodynia in a rat model of antiretroviral toxic neuropathy (ATN) when administered at a dose of 75 mg/kg twice weekly for five consecutive doses for a cumulative dose of 375 mg/kg.{53217} Formulations containing stavudine, in combination with other antiretrovirals, have been used in the treatment of HIV-1 infection.
Brand:CaymanSKU:- Stavudine is an inhibitor of HIV reverse transcriptase and a derivative of the nucleoside thymidine (Item No. 20519).{53215} It inhibits HIV-1 replication in human peripheral blood mononuclear cells (PBMCs; EC50 = 8.8 nM). Stavudine reduces the synthesis of HIV-specific antigen in MT-4 cells when used at concentrations ranging from 0.1 to 10 µg/ml and reduces HIV-induced plaque formation in MT-4 cells at 0.05 µg/ml.{29420} It reduces plasma- and cell-associated viral load in macaques infected with a highly pathogenic isolate of HIV-2.{53216} Stavudine induces sustained hind paw mechanical allodynia in a rat model of antiretroviral toxic neuropathy (ATN) when administered at a dose of 75 mg/kg twice weekly for five consecutive doses for a cumulative dose of 375 mg/kg.{53217} Formulations containing stavudine, in combination with other antiretrovirals, have been used in the treatment of HIV-1 infection.
Brand:CaymanSKU:- Stavudine is an inhibitor of HIV reverse transcriptase and a derivative of the nucleoside thymidine (Item No. 20519).{53215} It inhibits HIV-1 replication in human peripheral blood mononuclear cells (PBMCs; EC50 = 8.8 nM). Stavudine reduces the synthesis of HIV-specific antigen in MT-4 cells when used at concentrations ranging from 0.1 to 10 µg/ml and reduces HIV-induced plaque formation in MT-4 cells at 0.05 µg/ml.{29420} It reduces plasma- and cell-associated viral load in macaques infected with a highly pathogenic isolate of HIV-2.{53216} Stavudine induces sustained hind paw mechanical allodynia in a rat model of antiretroviral toxic neuropathy (ATN) when administered at a dose of 75 mg/kg twice weekly for five consecutive doses for a cumulative dose of 375 mg/kg.{53217} Formulations containing stavudine, in combination with other antiretrovirals, have been used in the treatment of HIV-1 infection.
Brand:CaymanSKU:-
Stearamide is a primary fatty acid amide that is often used in the synthesis of organic chemicals and surfactants. Levels of stearamide are reported to be up-regulated in the serum of patients with hepatic cirrhosis.{33148} Thus, it may be a potential biomarker for disordered fatty acid metabolism related to fatty liver diseases.
Brand:CaymanSKU:21087 -Out of stock
Stearamide is a primary fatty acid amide that is often used in the synthesis of organic chemicals and surfactants. Levels of stearamide are reported to be up-regulated in the serum of patients with hepatic cirrhosis.{33148} Thus, it may be a potential biomarker for disordered fatty acid metabolism related to fatty liver diseases.
Brand:CaymanSKU:21087 -Out of stock
Stearamide is a primary fatty acid amide that is often used in the synthesis of organic chemicals and surfactants. Levels of stearamide are reported to be up-regulated in the serum of patients with hepatic cirrhosis.{33148} Thus, it may be a potential biomarker for disordered fatty acid metabolism related to fatty liver diseases.
Brand:CaymanSKU:21087 -Out of stock
Stearamide is a primary fatty acid amide that is often used in the synthesis of organic chemicals and surfactants. Levels of stearamide are reported to be up-regulated in the serum of patients with hepatic cirrhosis.{33148} Thus, it may be a potential biomarker for disordered fatty acid metabolism related to fatty liver diseases.
Brand:CaymanSKU:21087 -Out of stock
Stearic acid is a long-chain saturated fatty acid. It is a major component of cocoa butter and has also been found in beef fat and vegetable oils.{48415,48416,48417} Unlike many long-chain saturated fatty acids, dietary stearic acid does not induce hypercholesterolemia or raise LDL-cholesterol.{48418}
Brand:CaymanSKU:10011298 - 1 gAvailable on backorder
Stearic acid is a long-chain saturated fatty acid. It is a major component of cocoa butter and has also been found in beef fat and vegetable oils.{48415,48416,48417} Unlike many long-chain saturated fatty acids, dietary stearic acid does not induce hypercholesterolemia or raise LDL-cholesterol.{48418}
Brand:CaymanSKU:10011298 - 10 gAvailable on backorder
Stearic acid is a long-chain saturated fatty acid. It is a major component of cocoa butter and has also been found in beef fat and vegetable oils.{48415,48416,48417} Unlike many long-chain saturated fatty acids, dietary stearic acid does not induce hypercholesterolemia or raise LDL-cholesterol.{48418}
Brand:CaymanSKU:10011298 - 5 gAvailable on backorder
Stearic acid is a long-chain saturated fatty acid. It is a major component of cocoa butter and has also been found in beef fat and vegetable oils.{48415,48416,48417} Unlike many long-chain saturated fatty acids, dietary stearic acid does not induce hypercholesterolemia or raise LDL-cholesterol.{48418}
Brand:CaymanSKU:10011298 - 500 mgAvailable on backorder
Stearic acid is a saturated fatty acid commonly found in animal and vegetable fats that is frequently used in cosmetics, candles, soaps, plastics, oil pastels, and for softening rubber. Stearic acid ethyl ester (ethyl stearate) is the neutral, more lipid soluble form of the free acid. It perturbs the cell cycle and induces apoptosis in HepG2 cells and is a marker of excessive alcohol consumption that can be isolated from an individual’s hair.{14158,14159}
Brand:CaymanSKU:10008196 - 100 mgAvailable on backorder
Stearic acid is a saturated fatty acid commonly found in animal and vegetable fats that is frequently used in cosmetics, candles, soaps, plastics, oil pastels, and for softening rubber. Stearic acid ethyl ester (ethyl stearate) is the neutral, more lipid soluble form of the free acid. It perturbs the cell cycle and induces apoptosis in HepG2 cells and is a marker of excessive alcohol consumption that can be isolated from an individual’s hair.{14158,14159}
Brand:CaymanSKU:10008196 - 500 mgAvailable on backorder
Stearic acid methyl ester is an esterified version of the free acid which is less water soluble but more amenable for the formulation of stearate-containing diets and dietary supplements. Stearic acid (Item No. 10011298) is a long-chain saturated fatty acid that can be derived from either animal fats or vegetable oils. Compared to other long-chain saturated fatty acids that are hypercholesterolemic, experimental diets high in stearic acid (9.3-11.8% of energy) do not raise plasma total cholesterol or LDL cholesterol concentrations but may slightly reduce HDL cholesterol concentrations.{15467,15469}
Brand:CaymanSKU:20609 -Available on backorder
Stearic acid methyl ester is an esterified version of the free acid which is less water soluble but more amenable for the formulation of stearate-containing diets and dietary supplements. Stearic acid (Item No. 10011298) is a long-chain saturated fatty acid that can be derived from either animal fats or vegetable oils. Compared to other long-chain saturated fatty acids that are hypercholesterolemic, experimental diets high in stearic acid (9.3-11.8% of energy) do not raise plasma total cholesterol or LDL cholesterol concentrations but may slightly reduce HDL cholesterol concentrations.{15467,15469}
Brand:CaymanSKU:20609 -Available on backorder
Stearic acid methyl ester is an esterified version of the free acid which is less water soluble but more amenable for the formulation of stearate-containing diets and dietary supplements. Stearic acid (Item No. 10011298) is a long-chain saturated fatty acid that can be derived from either animal fats or vegetable oils. Compared to other long-chain saturated fatty acids that are hypercholesterolemic, experimental diets high in stearic acid (9.3-11.8% of energy) do not raise plasma total cholesterol or LDL cholesterol concentrations but may slightly reduce HDL cholesterol concentrations.{15467,15469}
Brand:CaymanSKU:20609 -Available on backorder
Stearic acid-13C is intended for use as an internal standard for the quantification of stearic acid (Item No. 10011298) by GC- or LC-MS. Stearic acid is a long-chain saturated fatty acid. It is a major component of cocoa butter and has also been found in beef fat and vegetable oils.{48415,48416,48417} Unlike many long-chain saturated fatty acids, dietary stearic acid does not induce hypercholesterolemia or raise LDL-cholesterol.{48418}
Brand:CaymanSKU:28917 - 1 gAvailable on backorder
Stearic acid-13C is intended for use as an internal standard for the quantification of stearic acid (Item No. 10011298) by GC- or LC-MS. Stearic acid is a long-chain saturated fatty acid. It is a major component of cocoa butter and has also been found in beef fat and vegetable oils.{48415,48416,48417} Unlike many long-chain saturated fatty acids, dietary stearic acid does not induce hypercholesterolemia or raise LDL-cholesterol.{48418}
Brand:CaymanSKU:28917 - 100 mgAvailable on backorder
Stearic acid-13C is intended for use as an internal standard for the quantification of stearic acid (Item No. 10011298) by GC- or LC-MS. Stearic acid is a long-chain saturated fatty acid. It is a major component of cocoa butter and has also been found in beef fat and vegetable oils.{48415,48416,48417} Unlike many long-chain saturated fatty acids, dietary stearic acid does not induce hypercholesterolemia or raise LDL-cholesterol.{48418}
Brand:CaymanSKU:28917 - 250 mgAvailable on backorder
Stearic acid-13C is intended for use as an internal standard for the quantification of stearic acid (Item No. 10011298) by GC- or LC-MS. Stearic acid is a long-chain saturated fatty acid. It is a major component of cocoa butter and has also been found in beef fat and vegetable oils.{48415,48416,48417} Unlike many long-chain saturated fatty acids, dietary stearic acid does not induce hypercholesterolemia or raise LDL-cholesterol.{48418}
Brand:CaymanSKU:28917 - 500 mgAvailable on backorder
Stearic acid-9,10-d2 is intended for use as an internal standard for the quantification of stearic acid (Item No. 10011298) by GC- or LC-MS. Stearic acid is a long-chain saturated fatty acid. It is a major component of cocoa butter and has also been found in beef fat and vegetable oils.{48415,48416,48417} Unlike many long-chain saturated fatty acids, dietary stearic acid does not induce hypercholesterolemia or raise LDL-cholesterol.{48418}
Brand:CaymanSKU:28868 - 1 mgAvailable on backorder
Stearic acid-9,10-d2 is intended for use as an internal standard for the quantification of stearic acid (Item No. 10011298) by GC- or LC-MS. Stearic acid is a long-chain saturated fatty acid. It is a major component of cocoa butter and has also been found in beef fat and vegetable oils.{48415,48416,48417} Unlike many long-chain saturated fatty acids, dietary stearic acid does not induce hypercholesterolemia or raise LDL-cholesterol.{48418}
Brand:CaymanSKU:28868 - 10 mgAvailable on backorder
Stearic acid-9,10-d2 is intended for use as an internal standard for the quantification of stearic acid (Item No. 10011298) by GC- or LC-MS. Stearic acid is a long-chain saturated fatty acid. It is a major component of cocoa butter and has also been found in beef fat and vegetable oils.{48415,48416,48417} Unlike many long-chain saturated fatty acids, dietary stearic acid does not induce hypercholesterolemia or raise LDL-cholesterol.{48418}
Brand:CaymanSKU:28868 - 25 mgAvailable on backorder
Stearic acid-9,10-d2 is intended for use as an internal standard for the quantification of stearic acid (Item No. 10011298) by GC- or LC-MS. Stearic acid is a long-chain saturated fatty acid. It is a major component of cocoa butter and has also been found in beef fat and vegetable oils.{48415,48416,48417} Unlike many long-chain saturated fatty acids, dietary stearic acid does not induce hypercholesterolemia or raise LDL-cholesterol.{48418}
Brand:CaymanSKU:28868 - 5 mgAvailable on backorder
Stearic Acid-d2 is intended for use as an internal standard for the quantification of stearic acid (Item No. 10011298) by GC- or LC-MS. Stearic acid is a long-chain saturated fatty acid. It is a major component of cocoa butter and has also been found in beef fat and vegetable oils.{48415,48416,48417} Unlike many long-chain saturated fatty acids, dietary stearic acid does not induce hypercholesterolemia or raise LDL-cholesterol.{48418}
Brand:CaymanSKU:28150 - 250 mgAvailable on backorder
Stearic Acid-d2 is intended for use as an internal standard for the quantification of stearic acid (Item No. 10011298) by GC- or LC-MS. Stearic acid is a long-chain saturated fatty acid. It is a major component of cocoa butter and has also been found in beef fat and vegetable oils.{48415,48416,48417} Unlike many long-chain saturated fatty acids, dietary stearic acid does not induce hypercholesterolemia or raise LDL-cholesterol.{48418}
Brand:CaymanSKU:28150 - 500 mgAvailable on backorder
Stearic acid-d35 is intended for use as an internal standard for the quantification of stearic acid (Item No. 10011298) by GC- or LC-MS. Stearic acid is a long-chain saturated fatty acid. It is a major component of cocoa butter and has also been found in beef fat and vegetable oils.{48415,48416,48417} Unlike many long-chain saturated fatty acids, dietary stearic acid does not induce hypercholesterolemia or raise LDL-cholesterol.{48418}
Brand:CaymanSKU:9003318 - 100 mgAvailable on backorder
Stearic acid-d35 is intended for use as an internal standard for the quantification of stearic acid (Item No. 10011298) by GC- or LC-MS. Stearic acid is a long-chain saturated fatty acid. It is a major component of cocoa butter and has also been found in beef fat and vegetable oils.{48415,48416,48417} Unlike many long-chain saturated fatty acids, dietary stearic acid does not induce hypercholesterolemia or raise LDL-cholesterol.{48418}
Brand:CaymanSKU:9003318 - 250 mgAvailable on backorder
Stearic acid-d35 is intended for use as an internal standard for the quantification of stearic acid (Item No. 10011298) by GC- or LC-MS. Stearic acid is a long-chain saturated fatty acid. It is a major component of cocoa butter and has also been found in beef fat and vegetable oils.{48415,48416,48417} Unlike many long-chain saturated fatty acids, dietary stearic acid does not induce hypercholesterolemia or raise LDL-cholesterol.{48418}
Brand:CaymanSKU:9003318 - 50 mgAvailable on backorder
Stearic acid-d4 is intended for use as an internal standard for the quantification of stearic acid (Item No. 10011298) by GC- or LC-MS. Stearic acid is a long-chain saturated fatty acid. It is a major component of cocoa butter and has also been found in beef fat and vegetable oils.{48415,48416,48417} Unlike many long-chain saturated fatty acids, dietary stearic acid does not induce hypercholesterolemia or raise LDL-cholesterol.{48418}
Brand:CaymanSKU:30549 - 10 mgAvailable on backorder
Stearic acid-d4 is intended for use as an internal standard for the quantification of stearic acid (Item No. 10011298) by GC- or LC-MS. Stearic acid is a long-chain saturated fatty acid. It is a major component of cocoa butter and has also been found in beef fat and vegetable oils.{48415,48416,48417} Unlike many long-chain saturated fatty acids, dietary stearic acid does not induce hypercholesterolemia or raise LDL-cholesterol.{48418}
Brand:CaymanSKU:30549 - 100 mgAvailable on backorder
Stearic acid-d4 is intended for use as an internal standard for the quantification of stearic acid (Item No. 10011298) by GC- or LC-MS. Stearic acid is a long-chain saturated fatty acid. It is a major component of cocoa butter and has also been found in beef fat and vegetable oils.{48415,48416,48417} Unlike many long-chain saturated fatty acids, dietary stearic acid does not induce hypercholesterolemia or raise LDL-cholesterol.{48418}
Brand:CaymanSKU:30549 - 250 mgAvailable on backorder
Stearic acid-d4 is intended for use as an internal standard for the quantification of stearic acid (Item No. 10011298) by GC- or LC-MS. Stearic acid is a long-chain saturated fatty acid. It is a major component of cocoa butter and has also been found in beef fat and vegetable oils.{48415,48416,48417} Unlike many long-chain saturated fatty acids, dietary stearic acid does not induce hypercholesterolemia or raise LDL-cholesterol.{48418}
Brand:CaymanSKU:30549 - 50 mgAvailable on backorder
Stearidonic acid is an 18-carbon, ω-3 fatty acid which is a dietary precursor to EPA and DHA. Stearidonic acid is present in small amounts in seed oils, especially black currant seed oil.
Brand:CaymanSKU:90320 - 1 mgAvailable on backorder
Stearidonic acid is an 18-carbon, ω-3 fatty acid which is a dietary precursor to EPA and DHA. Stearidonic acid is present in small amounts in seed oils, especially black currant seed oil.
Brand:CaymanSKU:90320 - 10 mgAvailable on backorder
Stearidonic acid is an 18-carbon, ω-3 fatty acid which is a dietary precursor to EPA and DHA. Stearidonic acid is present in small amounts in seed oils, especially black currant seed oil.
Brand:CaymanSKU:90320 - 25 mgAvailable on backorder