Cayman
Showing 40051–40200 of 45550 results
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C16 Sphingosine-1-phosphate (C16 S1P) is a derivative of sphingosine-1-phosphate (S1P; Item No. 62570) that binds to S1P1/EDG-1, S1P3/EDG-3, and S1P2/EDG-5 receptors with affinities of 115%, 83%, and 103%, respectively, relative to S1P in CHO cells.{41024} C16 S1P was increased in postmortem primary open angle glaucoma trabecular meshwork samples.{41023}
Brand:CaymanSKU:9002921 - 1 mgAvailable on backorder
C16 Sphingosine-1-phosphate (C16 S1P) is a derivative of sphingosine-1-phosphate (S1P; Item No. 62570) that binds to S1P1/EDG-1, S1P3/EDG-3, and S1P2/EDG-5 receptors with affinities of 115%, 83%, and 103%, respectively, relative to S1P in CHO cells.{41024} C16 S1P was increased in postmortem primary open angle glaucoma trabecular meshwork samples.{41023}
Brand:CaymanSKU:9002921 - 5 mgAvailable on backorder
C16 Sphingosine-1-phosphate (C16 S1P) is a derivative of sphingosine-1-phosphate (S1P; Item No. 62570) that binds to S1P1/EDG-1, S1P3/EDG-3, and S1P2/EDG-5 receptors with affinities of 115%, 83%, and 103%, respectively, relative to S1P in CHO cells.{41024} C16 S1P was increased in postmortem primary open angle glaucoma trabecular meshwork samples.{41023}
Brand:CaymanSKU:9002921 - 500 µgAvailable on backorder
Sphingosine-1-phosphate (S1P) (d17:1) is a synthetic sphingolipid that has been used as an internal standard for the quantification of sphingosine-1-phosphate (d18:1) (Item No. 62570) in plasma and tissue samples.{38420,39602}
Brand:CaymanSKU:22498 -Out of stock
Sphingosine-1-phosphate (S1P) (d17:1) is a synthetic sphingolipid that has been used as an internal standard for the quantification of sphingosine-1-phosphate (d18:1) (Item No. 62570) in plasma and tissue samples.{38420,39602}
Brand:CaymanSKU:22498 -Out of stock
Sphingosine-1-phosphate (S1P) (d17:1) is a synthetic sphingolipid that has been used as an internal standard for the quantification of sphingosine-1-phosphate (d18:1) (Item No. 62570) in plasma and tissue samples.{38420,39602}
Brand:CaymanSKU:22498 -Out of stock
Sphingosine-1-phosphate (S1P) is the product of phosphorylation of sphingosine by sphingosine kinase that is secreted from cells and acts as an agonist at S1P receptors.{45658,2815} It increases intracellular calcium levels in TAg-Jurkat cells expressing S1P1 and Gqi5, which allows for phospholipase C stimulation by Gi proteins, when used at a concentration of 200 nM, as well as in TAg-Jurkat cells expressing S1P2 and S1P3 receptors (EC50s = 8 and 11 nM, respectively).{45659} Intra- and extracellular levels of S1P vary spatially allowing it to function as an autocrine or paracrine factor, respectively, and dysregulation of S1P levels are associated with various disease states, such as inflammation and autoimmunity.{45660} S1P has a wide variety of effects, including an involvement in cell growth, angiogenesis, immunity, and neuroprotection.
Brand:CaymanSKU:62570 - 1 mgAvailable on backorder
Sphingosine-1-phosphate (S1P) is the product of phosphorylation of sphingosine by sphingosine kinase that is secreted from cells and acts as an agonist at S1P receptors.{45658,2815} It increases intracellular calcium levels in TAg-Jurkat cells expressing S1P1 and Gqi5, which allows for phospholipase C stimulation by Gi proteins, when used at a concentration of 200 nM, as well as in TAg-Jurkat cells expressing S1P2 and S1P3 receptors (EC50s = 8 and 11 nM, respectively).{45659} Intra- and extracellular levels of S1P vary spatially allowing it to function as an autocrine or paracrine factor, respectively, and dysregulation of S1P levels are associated with various disease states, such as inflammation and autoimmunity.{45660} S1P has a wide variety of effects, including an involvement in cell growth, angiogenesis, immunity, and neuroprotection.
Brand:CaymanSKU:62570 - 10 mgAvailable on backorder
Sphingosine-1-phosphate (S1P) is the product of phosphorylation of sphingosine by sphingosine kinase that is secreted from cells and acts as an agonist at S1P receptors.{45658,2815} It increases intracellular calcium levels in TAg-Jurkat cells expressing S1P1 and Gqi5, which allows for phospholipase C stimulation by Gi proteins, when used at a concentration of 200 nM, as well as in TAg-Jurkat cells expressing S1P2 and S1P3 receptors (EC50s = 8 and 11 nM, respectively).{45659} Intra- and extracellular levels of S1P vary spatially allowing it to function as an autocrine or paracrine factor, respectively, and dysregulation of S1P levels are associated with various disease states, such as inflammation and autoimmunity.{45660} S1P has a wide variety of effects, including an involvement in cell growth, angiogenesis, immunity, and neuroprotection.
Brand:CaymanSKU:62570 - 25 mgAvailable on backorder
Sphingosine-1-phosphate (S1P) is the product of phosphorylation of sphingosine by sphingosine kinase that is secreted from cells and acts as an agonist at S1P receptors.{45658,2815} It increases intracellular calcium levels in TAg-Jurkat cells expressing S1P1 and Gqi5, which allows for phospholipase C stimulation by Gi proteins, when used at a concentration of 200 nM, as well as in TAg-Jurkat cells expressing S1P2 and S1P3 receptors (EC50s = 8 and 11 nM, respectively).{45659} Intra- and extracellular levels of S1P vary spatially allowing it to function as an autocrine or paracrine factor, respectively, and dysregulation of S1P levels are associated with various disease states, such as inflammation and autoimmunity.{45660} S1P has a wide variety of effects, including an involvement in cell growth, angiogenesis, immunity, and neuroprotection.
Brand:CaymanSKU:62570 - 5 mgAvailable on backorder
Sphingosine-1-phosphate-d7 is intended for use as an internal standard for the quantification of sphingosine-1-phosphate (S1P; Item No. 62570) by GC- or LC-MS. S1P is the product of phosphorylation of sphingosine by sphingosine kinase that is secreted from cells and acts as an agonist at S1P receptors.{45658} It increases intracellular calcium levels in TAg-Jurkat cells expressing S1P1 and Gqi5, which allows for phospholipase C stimulation by Gi proteins, when used at a concentration of 200 nM, as well as in TAg-Jurkat cells expressing S1P2 and S1P3 receptors (EC50s = 8 and 11 nM, respectively).{45659} Intra- and extracellular levels of S1P vary spatially allowing it to function as an autocrine or paracrine factor, respectively, and dysregulation of S1P levels are associated with various disease states, such as inflammation and autoimmunity.{45660} S1P has a wide variety of effects, including an involvement in cell growth, angiogenesis, immunity, and neuroprotection.
Brand:CaymanSKU:10008121 - 1 mgAvailable on backorder
Sphingosine-1-phosphate-d7 is intended for use as an internal standard for the quantification of sphingosine-1-phosphate (S1P; Item No. 62570) by GC- or LC-MS. S1P is the product of phosphorylation of sphingosine by sphingosine kinase that is secreted from cells and acts as an agonist at S1P receptors.{45658} It increases intracellular calcium levels in TAg-Jurkat cells expressing S1P1 and Gqi5, which allows for phospholipase C stimulation by Gi proteins, when used at a concentration of 200 nM, as well as in TAg-Jurkat cells expressing S1P2 and S1P3 receptors (EC50s = 8 and 11 nM, respectively).{45659} Intra- and extracellular levels of S1P vary spatially allowing it to function as an autocrine or paracrine factor, respectively, and dysregulation of S1P levels are associated with various disease states, such as inflammation and autoimmunity.{45660} S1P has a wide variety of effects, including an involvement in cell growth, angiogenesis, immunity, and neuroprotection.
Brand:CaymanSKU:10008121 - 500 µgAvailable on backorder
Sphingosine-d7 (d18:1) is intended for use as an internal standard for the quantification of sphingosine (d18:1) (Item No. 10007907) by GC- or LC-MS. Sphingosine (d18:1) is formed primarily from the breakdown of ceramide.{13592} Sphingosine (d18:1) inhibits protein kinase C and phosphatidic acid phosphohydrolase, whereas it activates phospholipase D and diacylglycerol (DAG) kinase.{13592} Phosphorylation of sphingosine (d18:1) by sphingosine kinases 1 and 2 (SPHK1, SPHK2) produces sphingosine-1-phosphate, a potent bioactive lipid that exhibits a broad spectrum of biological activities including cell proliferation, survival, migration, cytoskeletal organization, and morphogenesis.{11895,12477,10628}
Brand:CaymanSKU:22786 -Out of stock
Sphingosine-d7 (d18:1) is intended for use as an internal standard for the quantification of sphingosine (d18:1) (Item No. 10007907) by GC- or LC-MS. Sphingosine (d18:1) is formed primarily from the breakdown of ceramide.{13592} Sphingosine (d18:1) inhibits protein kinase C and phosphatidic acid phosphohydrolase, whereas it activates phospholipase D and diacylglycerol (DAG) kinase.{13592} Phosphorylation of sphingosine (d18:1) by sphingosine kinases 1 and 2 (SPHK1, SPHK2) produces sphingosine-1-phosphate, a potent bioactive lipid that exhibits a broad spectrum of biological activities including cell proliferation, survival, migration, cytoskeletal organization, and morphogenesis.{11895,12477,10628}
Brand:CaymanSKU:22786 -Out of stock
SPHINX31 is a potent inhibitor of serine/arginine-rich protein kinase 1 (SRPK1; IC50 = 5.9 nM).{33350} It is selective for SRPK1 over a panel of 50 kinases at a concentration of 1 μM. SPHINX31 inhibits phosphorylation of serine/arginine-rich splicing factor 1 (SRSF1), an SRPK1 substrate, in PC3 cells (EC50 = 360 nM) and increases expression of the anti-angiogenic VEGF-A165b splice variant in retinal pigment epithelial (RPE) cells. In vivo, SPHINX31 (2 μg per eye) inhibits blood vessel growth and macrophage infiltration in the eyes of a mouse model of choroidal neovascularization.
Brand:CaymanSKU:21582 -Out of stock
SPHINX31 is a potent inhibitor of serine/arginine-rich protein kinase 1 (SRPK1; IC50 = 5.9 nM).{33350} It is selective for SRPK1 over a panel of 50 kinases at a concentration of 1 μM. SPHINX31 inhibits phosphorylation of serine/arginine-rich splicing factor 1 (SRSF1), an SRPK1 substrate, in PC3 cells (EC50 = 360 nM) and increases expression of the anti-angiogenic VEGF-A165b splice variant in retinal pigment epithelial (RPE) cells. In vivo, SPHINX31 (2 μg per eye) inhibits blood vessel growth and macrophage infiltration in the eyes of a mouse model of choroidal neovascularization.
Brand:CaymanSKU:21582 -Out of stock
SPHINX31 is a potent inhibitor of serine/arginine-rich protein kinase 1 (SRPK1; IC50 = 5.9 nM).{33350} It is selective for SRPK1 over a panel of 50 kinases at a concentration of 1 μM. SPHINX31 inhibits phosphorylation of serine/arginine-rich splicing factor 1 (SRSF1), an SRPK1 substrate, in PC3 cells (EC50 = 360 nM) and increases expression of the anti-angiogenic VEGF-A165b splice variant in retinal pigment epithelial (RPE) cells. In vivo, SPHINX31 (2 μg per eye) inhibits blood vessel growth and macrophage infiltration in the eyes of a mouse model of choroidal neovascularization.
Brand:CaymanSKU:21582 -Out of stock
SPHINX31 is a potent inhibitor of serine/arginine-rich protein kinase 1 (SRPK1; IC50 = 5.9 nM).{33350} It is selective for SRPK1 over a panel of 50 kinases at a concentration of 1 μM. SPHINX31 inhibits phosphorylation of serine/arginine-rich splicing factor 1 (SRSF1), an SRPK1 substrate, in PC3 cells (EC50 = 360 nM) and increases expression of the anti-angiogenic VEGF-A165b splice variant in retinal pigment epithelial (RPE) cells. In vivo, SPHINX31 (2 μg per eye) inhibits blood vessel growth and macrophage infiltration in the eyes of a mouse model of choroidal neovascularization.
Brand:CaymanSKU:21582 -Out of stock
Sphynolactone-7 (SPL7) is an agonist of Striga hyposensitive to light receptor 7 (ShHTL7), which is found in the parasitic plant S. hermonthica.{35472} It selectively binds to ShHTL7 (IC50 = 0.31 µM) over ShHTL2-6, ShHTL9-10, and the strigolactone receptor AtD14 at 10 µM but does inhibit ShHTL8 and ShHTL11 (IC50s = 1.2 and 7.8 µM, respectively). SPL7 induces S. hermonthica seed germination in the absence of a host, which is fatal to this obligate parasite, with a minimum effective concentration of 10 fM. It induces suicidal germination of S. hermonthica seeds and decreases the number of plants emerging from the soil, as well as reduces S. hermonthica-induced senescence in maize plants when pre-applied to the soil of co-cultivated maize plants and S. hermonthica seeds at a concentration of 10 nM.
Brand:CaymanSKU:26922 - 1 mgAvailable on backorder
Sphynolactone-7 (SPL7) is an agonist of Striga hyposensitive to light receptor 7 (ShHTL7), which is found in the parasitic plant S. hermonthica.{35472} It selectively binds to ShHTL7 (IC50 = 0.31 µM) over ShHTL2-6, ShHTL9-10, and the strigolactone receptor AtD14 at 10 µM but does inhibit ShHTL8 and ShHTL11 (IC50s = 1.2 and 7.8 µM, respectively). SPL7 induces S. hermonthica seed germination in the absence of a host, which is fatal to this obligate parasite, with a minimum effective concentration of 10 fM. It induces suicidal germination of S. hermonthica seeds and decreases the number of plants emerging from the soil, as well as reduces S. hermonthica-induced senescence in maize plants when pre-applied to the soil of co-cultivated maize plants and S. hermonthica seeds at a concentration of 10 nM.
Brand:CaymanSKU:26922 - 10 mgAvailable on backorder
Sphynolactone-7 (SPL7) is an agonist of Striga hyposensitive to light receptor 7 (ShHTL7), which is found in the parasitic plant S. hermonthica.{35472} It selectively binds to ShHTL7 (IC50 = 0.31 µM) over ShHTL2-6, ShHTL9-10, and the strigolactone receptor AtD14 at 10 µM but does inhibit ShHTL8 and ShHTL11 (IC50s = 1.2 and 7.8 µM, respectively). SPL7 induces S. hermonthica seed germination in the absence of a host, which is fatal to this obligate parasite, with a minimum effective concentration of 10 fM. It induces suicidal germination of S. hermonthica seeds and decreases the number of plants emerging from the soil, as well as reduces S. hermonthica-induced senescence in maize plants when pre-applied to the soil of co-cultivated maize plants and S. hermonthica seeds at a concentration of 10 nM.
Brand:CaymanSKU:26922 - 5 mgAvailable on backorder
SPI 112 is cell-impermeable inhibitor of Src homology region 2 domain-containing phosphatase 2 (SHP-2) in cell-free assays (IC50 = 1 µM).{45697} It selectively inhibits SHP-2 over SHP-1 and protein tyrosine phosphatase 1B (PTP1B; IC50s = 18.3 and 14.5 µM, respectively).
Brand:CaymanSKU:29474 - 100 mgAvailable on backorder
SPI 112 is cell-impermeable inhibitor of Src homology region 2 domain-containing phosphatase 2 (SHP-2) in cell-free assays (IC50 = 1 µM).{45697} It selectively inhibits SHP-2 over SHP-1 and protein tyrosine phosphatase 1B (PTP1B; IC50s = 18.3 and 14.5 µM, respectively).
Brand:CaymanSKU:29474 - 25 mgAvailable on backorder
SPI 112 is cell-impermeable inhibitor of Src homology region 2 domain-containing phosphatase 2 (SHP-2) in cell-free assays (IC50 = 1 µM).{45697} It selectively inhibits SHP-2 over SHP-1 and protein tyrosine phosphatase 1B (PTP1B; IC50s = 18.3 and 14.5 µM, respectively).
Brand:CaymanSKU:29474 - 250 mgAvailable on backorder
SPI 112 is cell-impermeable inhibitor of Src homology region 2 domain-containing phosphatase 2 (SHP-2) in cell-free assays (IC50 = 1 µM).{45697} It selectively inhibits SHP-2 over SHP-1 and protein tyrosine phosphatase 1B (PTP1B; IC50s = 18.3 and 14.5 µM, respectively).
Brand:CaymanSKU:29474 - 50 mgAvailable on backorder
Brand:CaymanSKU:31334 - 10 mgAvailable on backorder
Brand:CaymanSKU:31334 - 25 mgAvailable on backorder
Spinetoram is an insecticide and a semisynthetic derivative of the insecticide spinosad (Item No. 25649).{45037} Spinetoram is a mixture of 3’-ethyl-5,6-dihydrospinosyn J and 3’-ethoxy-spinosyn L (Item No. 26664). It induces mortality in H. armigera third, fourth, and fifth instar larvae when administered in the diet at 0.19 and 0.36 mg/kg and decreases pupal survival and adult emergence in surviving larvae.{46292} It also induces mortality of wild-type D. melanogaster but not D. melanogaster containing a genetic mutation in the Dα6 subunit of the nicotinic acetylcholine receptor (nAChR; LC50s = 0.025 and 4.4 µg/cm2, respectively, administered in the diet).{46293} Formulations containing spinetoram have been used as insecticides in agriculture.
Brand:CaymanSKU:26623 - 1 mgAvailable on backorder
Spinetoram is an insecticide and a semisynthetic derivative of the insecticide spinosad (Item No. 25649).{45037} Spinetoram is a mixture of 3’-ethyl-5,6-dihydrospinosyn J and 3’-ethoxy-spinosyn L (Item No. 26664). It induces mortality in H. armigera third, fourth, and fifth instar larvae when administered in the diet at 0.19 and 0.36 mg/kg and decreases pupal survival and adult emergence in surviving larvae.{46292} It also induces mortality of wild-type D. melanogaster but not D. melanogaster containing a genetic mutation in the Dα6 subunit of the nicotinic acetylcholine receptor (nAChR; LC50s = 0.025 and 4.4 µg/cm2, respectively, administered in the diet).{46293} Formulations containing spinetoram have been used as insecticides in agriculture.
Brand:CaymanSKU:26623 - 10 mgAvailable on backorder
Spinetoram is an insecticide and a semisynthetic derivative of the insecticide spinosad (Item No. 25649).{45037} Spinetoram is a mixture of 3’-ethyl-5,6-dihydrospinosyn J and 3’-ethoxy-spinosyn L (Item No. 26664). It induces mortality in H. armigera third, fourth, and fifth instar larvae when administered in the diet at 0.19 and 0.36 mg/kg and decreases pupal survival and adult emergence in surviving larvae.{46292} It also induces mortality of wild-type D. melanogaster but not D. melanogaster containing a genetic mutation in the Dα6 subunit of the nicotinic acetylcholine receptor (nAChR; LC50s = 0.025 and 4.4 µg/cm2, respectively, administered in the diet).{46293} Formulations containing spinetoram have been used as insecticides in agriculture.
Brand:CaymanSKU:26623 - 25 mgAvailable on backorder
Spinetoram is an insecticide and a semisynthetic derivative of the insecticide spinosad (Item No. 25649).{45037} Spinetoram is a mixture of 3’-ethyl-5,6-dihydrospinosyn J and 3’-ethoxy-spinosyn L (Item No. 26664). It induces mortality in H. armigera third, fourth, and fifth instar larvae when administered in the diet at 0.19 and 0.36 mg/kg and decreases pupal survival and adult emergence in surviving larvae.{46292} It also induces mortality of wild-type D. melanogaster but not D. melanogaster containing a genetic mutation in the Dα6 subunit of the nicotinic acetylcholine receptor (nAChR; LC50s = 0.025 and 4.4 µg/cm2, respectively, administered in the diet).{46293} Formulations containing spinetoram have been used as insecticides in agriculture.
Brand:CaymanSKU:26623 - 5 mgAvailable on backorder
Spinorphin is a heptapeptide inhibitor of the enkephalin-degrading enzymes aminopeptidase, dipeptidyl aminopeptidase, angiotensin-converting enzyme (ACE), and enkephalinase (IC50s = 3.3, 1.4, 2.4, and 10 µg/ml, respectively, for the monkey brain enzymes).{53716} It is selective for these enzymes over human serum aminopeptidase A (IC50 = >100 µg/ml), as well as porcine kidney aminopeptidase B, aminopeptidase M, dipeptidyl peptidase 1 (DPP-1), DPP-2, DPP-3, and DPP-4 (IC50s = >55 µg/ml for all). Spinorphin inhibits chemotaxis, production of reactive oxygen species (ROS), and exocytosis of glucuronidase and collagenase in polymorphonuclear neutrophils (PMNs). It potentiates enkephalin-induced action potentials in rat hippocampal slices. Spinorphin (5 µg/animal) enhances the antinociceptive effects of Leu-enkephalin (Item No. 23283) in mice.{43324}
Brand:CaymanSKU:29914 - 1 mgAvailable on backorder
Spinorphin is a heptapeptide inhibitor of the enkephalin-degrading enzymes aminopeptidase, dipeptidyl aminopeptidase, angiotensin-converting enzyme (ACE), and enkephalinase (IC50s = 3.3, 1.4, 2.4, and 10 µg/ml, respectively, for the monkey brain enzymes).{53716} It is selective for these enzymes over human serum aminopeptidase A (IC50 = >100 µg/ml), as well as porcine kidney aminopeptidase B, aminopeptidase M, dipeptidyl peptidase 1 (DPP-1), DPP-2, DPP-3, and DPP-4 (IC50s = >55 µg/ml for all). Spinorphin inhibits chemotaxis, production of reactive oxygen species (ROS), and exocytosis of glucuronidase and collagenase in polymorphonuclear neutrophils (PMNs). It potentiates enkephalin-induced action potentials in rat hippocampal slices. Spinorphin (5 µg/animal) enhances the antinociceptive effects of Leu-enkephalin (Item No. 23283) in mice.{43324}
Brand:CaymanSKU:29914 - 10 mgAvailable on backorder
Spinorphin is a heptapeptide inhibitor of the enkephalin-degrading enzymes aminopeptidase, dipeptidyl aminopeptidase, angiotensin-converting enzyme (ACE), and enkephalinase (IC50s = 3.3, 1.4, 2.4, and 10 µg/ml, respectively, for the monkey brain enzymes).{53716} It is selective for these enzymes over human serum aminopeptidase A (IC50 = >100 µg/ml), as well as porcine kidney aminopeptidase B, aminopeptidase M, dipeptidyl peptidase 1 (DPP-1), DPP-2, DPP-3, and DPP-4 (IC50s = >55 µg/ml for all). Spinorphin inhibits chemotaxis, production of reactive oxygen species (ROS), and exocytosis of glucuronidase and collagenase in polymorphonuclear neutrophils (PMNs). It potentiates enkephalin-induced action potentials in rat hippocampal slices. Spinorphin (5 µg/animal) enhances the antinociceptive effects of Leu-enkephalin (Item No. 23283) in mice.{43324}
Brand:CaymanSKU:29914 - 5 mgAvailable on backorder
Spinorphin is a heptapeptide inhibitor of the enkephalin-degrading enzymes aminopeptidase, dipeptidyl aminopeptidase, angiotensin-converting enzyme (ACE), and enkephalinase (IC50s = 3.3, 1.4, 2.4, and 10 µg/ml, respectively, for the monkey brain enzymes).{53716} It is selective for these enzymes over human serum aminopeptidase A (IC50 = >100 µg/ml), as well as porcine kidney aminopeptidase B, aminopeptidase M, dipeptidyl peptidase 1 (DPP-1), DPP-2, DPP-3, and DPP-4 (IC50s = >55 µg/ml for all). Spinorphin inhibits chemotaxis, production of reactive oxygen species (ROS), and exocytosis of glucuronidase and collagenase in polymorphonuclear neutrophils (PMNs). It potentiates enkephalin-induced action potentials in rat hippocampal slices. Spinorphin (5 µg/animal) enhances the antinociceptive effects of Leu-enkephalin (Item No. 23283) in mice.{43324}
Brand:CaymanSKU:29914 - 500 µgAvailable on backorder
Spinosad is a naturally-occurring insecticide found in the the soil bacterium S. spinosa.{26995} It is a mixture of the macrocyclic lactones spinosyn A (Item No. 16528) and spinosyn D (Item No. 19158), which act as agonists of insect nicotinic acetylcholinesterase receptors (nAChRs). Oral administration of spinosad induces toxicity in fruit flies including C. capitata, B. curcurbitae, and B. dorsalis (LC50s = 2.8-4.2, 4.3-5.5, and 3.1-3.3 µg/ml, respectively) but has low toxicity in vertebrates.{39930,42230,26996} It also inhibits canine P-glycoprotein (P-gp; IC50 = 0.2 µg/ml).{39931} Formulations containing spinosad have been used in the agricultural and veterinary control of insects.
Brand:CaymanSKU:25649 - 10 mgAvailable on backorder
Spinosad is a naturally-occurring insecticide found in the the soil bacterium S. spinosa.{26995} It is a mixture of the macrocyclic lactones spinosyn A (Item No. 16528) and spinosyn D (Item No. 19158), which act as agonists of insect nicotinic acetylcholinesterase receptors (nAChRs). Oral administration of spinosad induces toxicity in fruit flies including C. capitata, B. curcurbitae, and B. dorsalis (LC50s = 2.8-4.2, 4.3-5.5, and 3.1-3.3 µg/ml, respectively) but has low toxicity in vertebrates.{39930,42230,26996} It also inhibits canine P-glycoprotein (P-gp; IC50 = 0.2 µg/ml).{39931} Formulations containing spinosad have been used in the agricultural and veterinary control of insects.
Brand:CaymanSKU:25649 - 25 mgAvailable on backorder
Spinosad is a naturally-occurring insecticide found in the the soil bacterium S. spinosa.{26995} It is a mixture of the macrocyclic lactones spinosyn A (Item No. 16528) and spinosyn D (Item No. 19158), which act as agonists of insect nicotinic acetylcholinesterase receptors (nAChRs). Oral administration of spinosad induces toxicity in fruit flies including C. capitata, B. curcurbitae, and B. dorsalis (LC50s = 2.8-4.2, 4.3-5.5, and 3.1-3.3 µg/ml, respectively) but has low toxicity in vertebrates.{39930,42230,26996} It also inhibits canine P-glycoprotein (P-gp; IC50 = 0.2 µg/ml).{39931} Formulations containing spinosad have been used in the agricultural and veterinary control of insects.
Brand:CaymanSKU:25649 - 5 mgAvailable on backorder
Spinosad is a naturally-occurring insecticide found in the the soil bacterium S. spinosa.{26995} It is a mixture of the macrocyclic lactones spinosyn A (Item No. 16528) and spinosyn D (Item No. 19158), which act as agonists of insect nicotinic acetylcholinesterase receptors (nAChRs). Oral administration of spinosad induces toxicity in fruit flies including C. capitata, B. curcurbitae, and B. dorsalis (LC50s = 2.8-4.2, 4.3-5.5, and 3.1-3.3 µg/ml, respectively) but has low toxicity in vertebrates.{39930,42230,26996} It also inhibits canine P-glycoprotein (P-gp; IC50 = 0.2 µg/ml).{39931} Formulations containing spinosad have been used in the agricultural and veterinary control of insects.
Brand:CaymanSKU:25649 - 50 mgAvailable on backorder
Spinosyn A is a naturally-occurring macrocyclic lactone that is a potent insecticide.{26992,26993} It acts as an agonist of insect nicotinic acetylcholinesterase receptors (nAChRs), which differ both structurally and functionally from nAChRs in vertebrates.{26995} As a result, it has low affinity for vertebrate nAChRs and has limited adverse effects in those animals.{26995,26996} Spinosyn A is produced naturally by the fermentation of the bacterium S. spinosa and its chemical synthesis has been described.{26994}
Brand:CaymanSKU:-Out of stock
Spinosyn A is a naturally-occurring macrocyclic lactone that is a potent insecticide.{26992,26993} It acts as an agonist of insect nicotinic acetylcholinesterase receptors (nAChRs), which differ both structurally and functionally from nAChRs in vertebrates.{26995} As a result, it has low affinity for vertebrate nAChRs and has limited adverse effects in those animals.{26995,26996} Spinosyn A is produced naturally by the fermentation of the bacterium S. spinosa and its chemical synthesis has been described.{26994}
Brand:CaymanSKU:-Out of stock
Spinosyn A 17-pseudoaglycone is a pseudoaglycone form of the macrocyclic lactone insecticide spinosyn A (Item No. 16528).{43158} Unlike spinosyn A, spinosyn A 17-pseudoaglycone is not lethal to tobacco budworm (H. virescens) neonate larvae (LC50 = >64 ppm).
Brand:CaymanSKU:25530 - 1 mgAvailable on backorder
Spinosyn A 17-pseudoaglycone is a pseudoaglycone form of the macrocyclic lactone insecticide spinosyn A (Item No. 16528).{43158} Unlike spinosyn A, spinosyn A 17-pseudoaglycone is not lethal to tobacco budworm (H. virescens) neonate larvae (LC50 = >64 ppm).
Brand:CaymanSKU:25530 - 5 mgAvailable on backorder
Spinosyn A aglycone is an aglycone form of the insecticide spinosyn A.{45038} It is formed by acid hydrolysis of spinosyn A 17-pseudoaglycone (Item No. 25530). Spinosyn A aglycone has no insecticidal activity at concentrations up to 64 ppm.
Brand:CaymanSKU:27992 - 1 mgAvailable on backorder
Spinosyn A aglycone is an aglycone form of the insecticide spinosyn A.{45038} It is formed by acid hydrolysis of spinosyn A 17-pseudoaglycone (Item No. 25530). Spinosyn A aglycone has no insecticidal activity at concentrations up to 64 ppm.
Brand:CaymanSKU:27992 - 5 mgAvailable on backorder
Spinosyn D is a spinosoid that is a minor component of spinosad, an insecticide based on chemical compounds found in a bacterial species isolated from sugarcane, S. spinosa.{26993} It acts as an agonist of insect nicotinic acetylcholinesterase receptors.{26993} Spinosyn D demonstrates insecticidal activity against H. virescens larvae (tobacco budworm) with an LD50 value of 0.8 ppm.{26992}
Brand:CaymanSKU:-Available on backorder
Spinosyn D is a spinosoid that is a minor component of spinosad, an insecticide based on chemical compounds found in a bacterial species isolated from sugarcane, S. spinosa.{26993} It acts as an agonist of insect nicotinic acetylcholinesterase receptors.{26993} Spinosyn D demonstrates insecticidal activity against H. virescens larvae (tobacco budworm) with an LD50 value of 0.8 ppm.{26992}
Brand:CaymanSKU:-Available on backorder
Spinosyn D 17-pseudoaglycone is a hydrolysis product of the minor insecticide component spinosyn D (Item No. 19158).{45038} Unlike spinosyn D, spinosyn D 17-pseudoaglycone is not lethal to tobacco budworms (H. virescens) when used at concentrations up to 64 ppm.
Brand:CaymanSKU:27975 - 2.5 mgAvailable on backorder
Spinosyn D 17-pseudoaglycone is a hydrolysis product of the minor insecticide component spinosyn D (Item No. 19158).{45038} Unlike spinosyn D, spinosyn D 17-pseudoaglycone is not lethal to tobacco budworms (H. virescens) when used at concentrations up to 64 ppm.
Brand:CaymanSKU:27975 - 500 µgAvailable on backorder
Spinosyn D aglycone is an aglycone form of the insecticide spinosyn D (Item No. 19158).{42776} Unlike spinosyn D, spinosyn D aglycone is not lethal to H. virescens (tobacco budworm) neonate larvae (LC50 = >64 ppm).
Brand:CaymanSKU:27937 - 2.5 mgAvailable on backorder
Spinosyn D aglycone is an aglycone form of the insecticide spinosyn D (Item No. 19158).{42776} Unlike spinosyn D, spinosyn D aglycone is not lethal to H. virescens (tobacco budworm) neonate larvae (LC50 = >64 ppm).
Brand:CaymanSKU:27937 - 500 µgAvailable on backorder
Spiramycin is a 16-membered macrolide antibiotic with anti-parasitic actions. Like other macrolides, spiramcyin inhibits microbial protein synthesis.{22680} It is effective against the parasitic protozoan T. gondii in clinical trials.{32005}
Brand:CaymanSKU:20267 -Available on backorder
Spiramycin is a 16-membered macrolide antibiotic with anti-parasitic actions. Like other macrolides, spiramcyin inhibits microbial protein synthesis.{22680} It is effective against the parasitic protozoan T. gondii in clinical trials.{32005}
Brand:CaymanSKU:20267 -Available on backorder
Spiramycin is a 16-membered macrolide antibiotic with anti-parasitic actions. Like other macrolides, spiramcyin inhibits microbial protein synthesis.{22680} It is effective against the parasitic protozoan T. gondii in clinical trials.{32005}
Brand:CaymanSKU:20267 -Available on backorder
Spiro-MeOTAD is a stable and efficient hole-transport material in organic light-emitting devices and in solid-state dye-sensitized solar cells (ssDSSCs).{28348} It yields higher ssDSSC efficiency compared to the liquid electrolyte for DSSC solar cells due to its reasonable charge carrier mobility and its amorphous nature and high solubility, which enables excellent infiltration into mesoporous titania films.{28348} Neutral spiro-MeOTAD absorbs light in the UV region of the spectrum, while its oxidized forms exhibit strong absorptions throughout the visible and near-infrared ranges.{28348}
Brand:CaymanSKU:-Available on backorder
Spiro-MeOTAD is a stable and efficient hole-transport material in organic light-emitting devices and in solid-state dye-sensitized solar cells (ssDSSCs).{28348} It yields higher ssDSSC efficiency compared to the liquid electrolyte for DSSC solar cells due to its reasonable charge carrier mobility and its amorphous nature and high solubility, which enables excellent infiltration into mesoporous titania films.{28348} Neutral spiro-MeOTAD absorbs light in the UV region of the spectrum, while its oxidized forms exhibit strong absorptions throughout the visible and near-infrared ranges.{28348}
Brand:CaymanSKU:-Available on backorder
Spiro-MeOTAD is a stable and efficient hole-transport material in organic light-emitting devices and in solid-state dye-sensitized solar cells (ssDSSCs).{28348} It yields higher ssDSSC efficiency compared to the liquid electrolyte for DSSC solar cells due to its reasonable charge carrier mobility and its amorphous nature and high solubility, which enables excellent infiltration into mesoporous titania films.{28348} Neutral spiro-MeOTAD absorbs light in the UV region of the spectrum, while its oxidized forms exhibit strong absorptions throughout the visible and near-infrared ranges.{28348}
Brand:CaymanSKU:-Available on backorder
Spiro-MeOTAD is a stable and efficient hole-transport material in organic light-emitting devices and in solid-state dye-sensitized solar cells (ssDSSCs).{28348} It yields higher ssDSSC efficiency compared to the liquid electrolyte for DSSC solar cells due to its reasonable charge carrier mobility and its amorphous nature and high solubility, which enables excellent infiltration into mesoporous titania films.{28348} Neutral spiro-MeOTAD absorbs light in the UV region of the spectrum, while its oxidized forms exhibit strong absorptions throughout the visible and near-infrared ranges.{28348}
Brand:CaymanSKU:-Available on backorder
Spiro-oxanthromicin A is a polyketide that has been found in Streptomyces.{38316} It induces mislocalization of K-RAS in MDCK cells (IC50 = 26.7 µM).
Brand:CaymanSKU:32555 - 100 µgAvailable on backorder
Spiro-oxanthromicin A is a polyketide that has been found in Streptomyces.{38316} It induces mislocalization of K-RAS in MDCK cells (IC50 = 26.7 µM).
Brand:CaymanSKU:32555 - 500 µgAvailable on backorder
Spirohexenolide A is a metabolite originally isolated from S. platensis.{42121} It inhibits growth in the NCI-60 cancer cell line panel (GI50s = 0.1-17 μM) with the RPMI-8226 multiple myeloma, HOP-92 lung, and SW620 colon cancer cell lines being most sensitive (GI50s = 254, 191, and 565 nM, respectively). Spirohexenolide A also binds to human macrophage migration inhibition factor (MIF; Kd = 35.9 μM) and inhibits MIF cellular uptake and lysosomal localization in HCT116 cells.{42122}
Brand:CaymanSKU:25116 - 100 µgAvailable on backorder
Spirohexenolide A is a metabolite originally isolated from S. platensis.{42121} It inhibits growth in the NCI-60 cancer cell line panel (GI50s = 0.1-17 μM) with the RPMI-8226 multiple myeloma, HOP-92 lung, and SW620 colon cancer cell lines being most sensitive (GI50s = 254, 191, and 565 nM, respectively). Spirohexenolide A also binds to human macrophage migration inhibition factor (MIF; Kd = 35.9 μM) and inhibits MIF cellular uptake and lysosomal localization in HCT116 cells.{42122}
Brand:CaymanSKU:25116 - 500 µgAvailable on backorder
Spirolaxine is a long-chain phthalide produced by the fungus S. laxum that has antibacterial properties.{34604,34610} Spirolaxine is a potent anti-H. pylori agent (MIC = 0.2 µg/cm3) with weak activity against E. coli.{34610,34608} Spirolaxine (1-40 µM) inhibits proliferation of endothelial (BMEC, HUVEC) and tumor (LoVo, HL-60) cells in culture.{34607} B. megaterium and C. echinulate produce hydroxylated metabolites of spirolaxine when given spirolaxine as a substrate.{34605}
Brand:CaymanSKU:22063 -Out of stock
Spirolaxine is a long-chain phthalide produced by the fungus S. laxum that has antibacterial properties.{34604,34610} Spirolaxine is a potent anti-H. pylori agent (MIC = 0.2 µg/cm3) with weak activity against E. coli.{34610,34608} Spirolaxine (1-40 µM) inhibits proliferation of endothelial (BMEC, HUVEC) and tumor (LoVo, HL-60) cells in culture.{34607} B. megaterium and C. echinulate produce hydroxylated metabolites of spirolaxine when given spirolaxine as a substrate.{34605}
Brand:CaymanSKU:22063 -Out of stock
Spiromesifen is an insecticide and acaricide that reduces lipid biosynthesis via inhibition of acetyl-CoA carboxylase.{43346,43347} It inhibits chitinase from Egyptian cotton leafworm (S. littoralis) larvae (IC50s = 0.60 and 0.72 μM for enzyme isolated from lab and field strains, respectively).{43348} It induces toxicity in whitefly (T. vaporariorum) nymphs (LC50 = 0.61 mg/L), spider mite (T. cinnabarinus) eggs (LC50 = 0.16 mg/kg), and second instar larvae of S. littoralis lab and field strains (LC50s = 0.44 and 0.68 ppm, respectively, at 72 hours post-application).{43346,43347,43348} Spiromesifen (600 mg/kg) also induces 50, 60, and 70% mortality in the Lepidoptera pests H. armigera, O. nubilalis, and P. xylostella, respectively, and induces 100% mortality in M. separata when used at a dose of 100 mg/kg.{43347} It induces toxicity in D. magna (EC50 = >0.092 mg a.s./L) and the fish species O. mykiss and L. macrochirus (LC50s = 0.016 and >0.034 mg a.s./L, respectively) but not rats (LD50 = >2,000 mg/kg).{43350} Spiromesifen also inhibits the human GST isozyme GSTA1-1 (IC50 = 12.1 μM).{43349}
Brand:CaymanSKU:25822 - 100 mgAvailable on backorder
Spiromesifen is an insecticide and acaricide that reduces lipid biosynthesis via inhibition of acetyl-CoA carboxylase.{43346,43347} It inhibits chitinase from Egyptian cotton leafworm (S. littoralis) larvae (IC50s = 0.60 and 0.72 μM for enzyme isolated from lab and field strains, respectively).{43348} It induces toxicity in whitefly (T. vaporariorum) nymphs (LC50 = 0.61 mg/L), spider mite (T. cinnabarinus) eggs (LC50 = 0.16 mg/kg), and second instar larvae of S. littoralis lab and field strains (LC50s = 0.44 and 0.68 ppm, respectively, at 72 hours post-application).{43346,43347,43348} Spiromesifen (600 mg/kg) also induces 50, 60, and 70% mortality in the Lepidoptera pests H. armigera, O. nubilalis, and P. xylostella, respectively, and induces 100% mortality in M. separata when used at a dose of 100 mg/kg.{43347} It induces toxicity in D. magna (EC50 = >0.092 mg a.s./L) and the fish species O. mykiss and L. macrochirus (LC50s = 0.016 and >0.034 mg a.s./L, respectively) but not rats (LD50 = >2,000 mg/kg).{43350} Spiromesifen also inhibits the human GST isozyme GSTA1-1 (IC50 = 12.1 μM).{43349}
Brand:CaymanSKU:25822 - 50 mgAvailable on backorder
Spironolactone (Item No. 9000324) is an analytical reference standard categorized as a steroid.{11234,33132} It is a diuretic that has been abused as a performance-enhancing drug and masking agent in sports doping.{33139} This product is intended for research and forensic applications
Brand:CaymanSKU:9000324 - 1 mgAvailable on backorder
Spironolactone (Item No. 9000324) is an analytical reference standard categorized as a steroid.{11234,33132} It is a diuretic that has been abused as a performance-enhancing drug and masking agent in sports doping.{33139} This product is intended for research and forensic applications
Brand:CaymanSKU:9000324 - 5 mgAvailable on backorder
Spirotetramat is an insecticide.{42381} It is active against C. pyri nymphs in vitro (LC50 = 6.51-12.53 mg AI/L) and induces mortality of C. pyri nymphs in European pear (P. communis) fields by 99.2% 15 days after application at a concentration of 27 g/hectare. Spirotetramat also reduces O. insidiosus embryonic viability and nymph survival.{42382} It exhibits aquatic toxicity, increasing expression of glutathione peroxidase (Gpx) and superoxide dismutase (SOD), decreasing production of malondialdehyde (MDA), and inducing lethality in Chinese toad (B. gargarizans) tadpoles (LC50 = 6.98 mg/L).{42383}
Brand:CaymanSKU:25634 - 100 mgAvailable on backorder
Spirotetramat is an insecticide.{42381} It is active against C. pyri nymphs in vitro (LC50 = 6.51-12.53 mg AI/L) and induces mortality of C. pyri nymphs in European pear (P. communis) fields by 99.2% 15 days after application at a concentration of 27 g/hectare. Spirotetramat also reduces O. insidiosus embryonic viability and nymph survival.{42382} It exhibits aquatic toxicity, increasing expression of glutathione peroxidase (Gpx) and superoxide dismutase (SOD), decreasing production of malondialdehyde (MDA), and inducing lethality in Chinese toad (B. gargarizans) tadpoles (LC50 = 6.98 mg/L).{42383}
Brand:CaymanSKU:25634 - 25 mgAvailable on backorder
Spirotetramat is an insecticide.{42381} It is active against C. pyri nymphs in vitro (LC50 = 6.51-12.53 mg AI/L) and induces mortality of C. pyri nymphs in European pear (P. communis) fields by 99.2% 15 days after application at a concentration of 27 g/hectare. Spirotetramat also reduces O. insidiosus embryonic viability and nymph survival.{42382} It exhibits aquatic toxicity, increasing expression of glutathione peroxidase (Gpx) and superoxide dismutase (SOD), decreasing production of malondialdehyde (MDA), and inducing lethality in Chinese toad (B. gargarizans) tadpoles (LC50 = 6.98 mg/L).{42383}
Brand:CaymanSKU:25634 - 50 mgAvailable on backorder
Spiroxamine is a tertiary amine fungicide and an inhibitor of Δ14 reductase/Δ8→Δ7 isomerase.{36876} It inhibits the growth of N. parvum, B. dothidea, D. seriata, and L. theobromae isolates from grape vines (EC50s = 0.97-10.28 mg/L).{36877} Spiroxamine (0.03-30 μM) reduces network formation in rat cortical cultures.{36878} It is also cytotoxic to MDA-kb2 cells (EC20 = 9.29 μM).{42005}
Brand:CaymanSKU:25823 - 100 mgAvailable on backorder
Spiroxamine is a tertiary amine fungicide and an inhibitor of Δ14 reductase/Δ8→Δ7 isomerase.{36876} It inhibits the growth of N. parvum, B. dothidea, D. seriata, and L. theobromae isolates from grape vines (EC50s = 0.97-10.28 mg/L).{36877} Spiroxamine (0.03-30 μM) reduces network formation in rat cortical cultures.{36878} It is also cytotoxic to MDA-kb2 cells (EC20 = 9.29 μM).{42005}
Brand:CaymanSKU:25823 - 50 mgAvailable on backorder
sPLA2s are found in the venom of certain snakes (Types IA, IIA, and IIB from vipers, cobras, rattlesnakes, and kraits), in pancreatic juices (Type IB), in rat and murine testes (Type IIC), in placenta, synovial fluids and platelets (Type IIA), and in heart, placenta, lung, mast cells, and P388D1 macrophages (Type V).{3941} Until 1994, the sPLA2 responsible for the release of arachidonic acid in inflammation was believed to be Type IIA. Although recently discovered isoforms of PLA2 clearly contribute to the release of arachidonic acid, sPLA2 (Type IIA) continues to be a protein of interest in the field of inflammation. This ELISA is specific for Type IIA sPLA2, and does not cross react with Type I, Type IV, Type V PLA2, inflammatory mediators such as tumor necrosis factor, interleukin-1, or platelet-activating factor. Cayman’s sPLA2 (human Type IIA) ELISA Kit is an immunometric assay that can be used for quantification of sPLA2 in plasma, synovial fluid, and other sample matrices.
Brand:CaymanSKU:501380 - 96 wellsAvailable on backorder
Antigen: human recombinant sPLA2 (type IIA) • Host: mouse • Cross-Reactivity: (+) human sPLA2 (type IIA); (−) bee venom sPLA2 (type III) and human sPLA2 (type V) • Application(s): IP and WB; other applications not tested • Isotype: IgG1 • Clone designation: SCACC353
Brand:CaymanSKU:160500- 1 ea Phospholipase A2 (PLA2) catalyzes the hydrolysis of phospholipids at the sn-2 position yielding a free fatty acid and a lysophospholipid.{2489} The release of arachidonic acid from membrane phospholipids by PLA2 is believed to be a key step in the control of eicosanoid production within the cell.{1474} Human synovial sPLA2 is a secreted, 14 kDa protein which is dependent on Ca2+ for optimal activity. Human synovial sPLA2 is 79% homologous to rat platelet and mouse type II sPLA2s.
Brand:CaymanSKU:160500 - 1 eaAvailable on backorder
Antigen: human recombinant sPLA2 (type IIA) • Host: mouse • Cross-Reactivity: (+) human sPLA2 (type IIA); (−) bee venom sPLA2 (type III) and human sPLA2 (type V) • Application(s): IP and WB; other applications not tested • Isotype: IgG1 • Clone designation: SCACC353
Brand:CaymanSKU:160500- 1 eaAvailable on backorder
Immunogen: Recombinant human sPLA2 (Type V), W79A mutant • Host: Mouse • Species Reactivity: (+) Human • Cross Reactivity: (−) human sPLA2 (type IIa), cPLA2, iPLA2 • Applications: ELISA and WB • Isotype: IgG1 • Clone designation: MCL-3G1
Brand:CaymanSKU:160510- 100 µg Phospholipase A2 (PLA2) catalyzes the hydrolysis of fatty acids at the sn-2 position of glycerophospholipids. PLA2 (type V) is a secretory PLA2 (sPLA2) of approximately 14 kDa and is one of the isoforms in the growing list of the PLA2 enzyme family.{3506} This enzyme, rather than the sPLA2 (type II), is responsible for arachidonic acid mobilization leading to prostaglandin production in macrophages and mast cells.{3941,4455,4053,8454} Consistent with this role, sPLA2 (type V) is associated with the golgi apparatus, nuclear envelope, and plasma membrane in murine bone marrow-derived mast cells.{7627} sPLA2 (type V) has been cloned from a variety of species including human, mouse, and rat.{7748,5754,7749} The enzyme is expressed in heart, lung, placenta, and spleen, as well as P388D1 macrophages and mast cells.{3941,4455,7749}
Brand:CaymanSKU:160510 - 100 µgAvailable on backorder
Immunogen: Recombinant human sPLA2 (Type V), W79A mutant • Host: Mouse • Species Reactivity: (+) Human • Cross Reactivity: (−) human sPLA2 (type IIa), cPLA2, iPLA2 • Applications: ELISA and WB • Isotype: IgG1 • Clone designation: MCL-3G1
Brand:CaymanSKU:160510- 100 µgAvailable on backorder
Immunogen: Synthetic peptide from an internal region of mouse protein • Host: Rabbit • Species Reactivity: (+) Human, mouse, rat • Cross Reactivity: (-) cPLA2, iPLA2, bee venom sPLA2, human synovial sPLA2 • Application: WB • MW = 16 kDa
Brand:CaymanSKU:160512- 500 µl