Cayman
Showing 39451–39600 of 45550 results
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SHS4121705 is an orally bioavailable mitochondrial uncoupler.{54188} It increases oxygen consumption rate in L6 rat myoblast cells with an EC50 value of 4.3 μM. SHS4121705 (25 mg/kg per day in the diet) reduces hepatic steatosis, liver triglyceride levels, and plasma alanine aminotransferase (ALT) levels in Stelic animal model (STAM) mice, a model of non-alcoholic steatohepatitis (NASH).
Brand:CaymanSKU:31053 - 10 mgAvailable on backorder
SHS4121705 is an orally bioavailable mitochondrial uncoupler.{54188} It increases oxygen consumption rate in L6 rat myoblast cells with an EC50 value of 4.3 μM. SHS4121705 (25 mg/kg per day in the diet) reduces hepatic steatosis, liver triglyceride levels, and plasma alanine aminotransferase (ALT) levels in Stelic animal model (STAM) mice, a model of non-alcoholic steatohepatitis (NASH).
Brand:CaymanSKU:31053 - 5 mgAvailable on backorder
SHU9119 is an agonist of melanocortin receptor 1 (MC1R) and antagonist of MC4R (IC50s = 1.2 and 2.9 nM, respectively, for displacement of melanocortin).{41427} It induces cAMP formation in HEK293 cells expressing human MC1R (EC50 = 1.11 nM), but inhibits cAMP formation in cells expressing human MC4R.{41427} In rats, SHU9119 (24 nmol, i.c.v. per day for seven days) increases food intake, body weight, fat mass, and lean mass, with concomitant increases in blood glucose, insulin, and leptin levels via disrupted melanocortin signaling.{41426} Similarly, mice treated with SHU9119 (5 nmol/day, i.c.v.) exhibit food intake-independent increases in body weight and fat mass consequent to MC4R inhibition and subsequent brown adipose tissue dysfunction.{41425}
Brand:CaymanSKU:24152 - 1 mgAvailable on backorder
SHU9119 is an agonist of melanocortin receptor 1 (MC1R) and antagonist of MC4R (IC50s = 1.2 and 2.9 nM, respectively, for displacement of melanocortin).{41427} It induces cAMP formation in HEK293 cells expressing human MC1R (EC50 = 1.11 nM), but inhibits cAMP formation in cells expressing human MC4R.{41427} In rats, SHU9119 (24 nmol, i.c.v. per day for seven days) increases food intake, body weight, fat mass, and lean mass, with concomitant increases in blood glucose, insulin, and leptin levels via disrupted melanocortin signaling.{41426} Similarly, mice treated with SHU9119 (5 nmol/day, i.c.v.) exhibit food intake-independent increases in body weight and fat mass consequent to MC4R inhibition and subsequent brown adipose tissue dysfunction.{41425}
Brand:CaymanSKU:24152 - 500 µgAvailable on backorder
Shz-1 is a Shz that activates cardiac differentiation, inducing the expression of early cardiac genes in mouse pluripotent and embryonic stem cells in vitro at low micromolar concentrations.{24724} In addition, Shz-1 drives differentiation of human peripheral blood mononuclear cells, mobilized by granule colony-stimulating factor, toward a cardiac phenotype.{24724} These Shz-1 treated cells enhance myocardial regenerative repair in cryo-injured rat heart.{24724}
Brand:CaymanSKU:- Shz-1 is a Shz that activates cardiac differentiation, inducing the expression of early cardiac genes in mouse pluripotent and embryonic stem cells in vitro at low micromolar concentrations.{24724} In addition, Shz-1 drives differentiation of human peripheral blood mononuclear cells, mobilized by granule colony-stimulating factor, toward a cardiac phenotype.{24724} These Shz-1 treated cells enhance myocardial regenerative repair in cryo-injured rat heart.{24724}
Brand:CaymanSKU:- Shz-1 is a Shz that activates cardiac differentiation, inducing the expression of early cardiac genes in mouse pluripotent and embryonic stem cells in vitro at low micromolar concentrations.{24724} In addition, Shz-1 drives differentiation of human peripheral blood mononuclear cells, mobilized by granule colony-stimulating factor, toward a cardiac phenotype.{24724} These Shz-1 treated cells enhance myocardial regenerative repair in cryo-injured rat heart.{24724}
Brand:CaymanSKU:- Shz-1 is a Shz that activates cardiac differentiation, inducing the expression of early cardiac genes in mouse pluripotent and embryonic stem cells in vitro at low micromolar concentrations.{24724} In addition, Shz-1 drives differentiation of human peripheral blood mononuclear cells, mobilized by granule colony-stimulating factor, toward a cardiac phenotype.{24724} These Shz-1 treated cells enhance myocardial regenerative repair in cryo-injured rat heart.{24724}
Brand:CaymanSKU:-
SI-2 is an inhibitor of steroid receptor coactivator 3 (SRC-3). It has been shown to selectively reduce the transcriptional activities and the protein concentrations of SRC-3 in cells through direct physical interactions with SRC-3.{31177} SI-2 induces death in various breast cancer cells with IC50 values of 3-20 nM without affecting normal cell viability.{31177} At 2 mg/kg, SI-2 can also inhibit primary tumor growth and reduce SRC-3 protein levels in an MDA-MB-468 breast cancer mouse model.{31177}
Brand:CaymanSKU:-Available on backorder
SI-2 is an inhibitor of steroid receptor coactivator 3 (SRC-3). It has been shown to selectively reduce the transcriptional activities and the protein concentrations of SRC-3 in cells through direct physical interactions with SRC-3.{31177} SI-2 induces death in various breast cancer cells with IC50 values of 3-20 nM without affecting normal cell viability.{31177} At 2 mg/kg, SI-2 can also inhibit primary tumor growth and reduce SRC-3 protein levels in an MDA-MB-468 breast cancer mouse model.{31177}
Brand:CaymanSKU:-Available on backorder
SI-2 is an inhibitor of steroid receptor coactivator 3 (SRC-3). It has been shown to selectively reduce the transcriptional activities and the protein concentrations of SRC-3 in cells through direct physical interactions with SRC-3.{31177} SI-2 induces death in various breast cancer cells with IC50 values of 3-20 nM without affecting normal cell viability.{31177} At 2 mg/kg, SI-2 can also inhibit primary tumor growth and reduce SRC-3 protein levels in an MDA-MB-468 breast cancer mouse model.{31177}
Brand:CaymanSKU:-Available on backorder
SI-2 is an inhibitor of steroid receptor coactivator 3 (SRC-3). It has been shown to selectively reduce the transcriptional activities and the protein concentrations of SRC-3 in cells through direct physical interactions with SRC-3.{31177} SI-2 induces death in various breast cancer cells with IC50 values of 3-20 nM without affecting normal cell viability.{31177} At 2 mg/kg, SI-2 can also inhibit primary tumor growth and reduce SRC-3 protein levels in an MDA-MB-468 breast cancer mouse model.{31177}
Brand:CaymanSKU:-Available on backorder
Siamycin I is a tricyclic peptide originally isolated from Streptomyces and has antiviral and antibacterial activities.{47469,47470} It is active against laboratory strains and clinical isolates of HIV-1 (ED50s = 0.05-0.45 and 0.89-5.7 μM, respectively), as well as the CBL-20 strain of HIV-2 (ED50 = 0.45 μM), in vitro.{47469} Siamycin I inhibits HIV-induced fusion of C8166 T cells with HIV-1-infected CEM-SS cells with an ED50 value of 0.08 μM. It is also active against B. subtilis, M. luteus, and S. aureus (MICs = 1.6-6.3 μg/ml).{47470} Siamycin I inhibits autophosphorylation of the E. faecalis quorum sensing kinase FsrC induced by gelatinase biosynthesis-activating pheromone (GBAP).{47471}
Brand:CaymanSKU:27783 - 1 mgAvailable on backorder
Siamycin I is a tricyclic peptide originally isolated from Streptomyces and has antiviral and antibacterial activities.{47469,47470} It is active against laboratory strains and clinical isolates of HIV-1 (ED50s = 0.05-0.45 and 0.89-5.7 μM, respectively), as well as the CBL-20 strain of HIV-2 (ED50 = 0.45 μM), in vitro.{47469} Siamycin I inhibits HIV-induced fusion of C8166 T cells with HIV-1-infected CEM-SS cells with an ED50 value of 0.08 μM. It is also active against B. subtilis, M. luteus, and S. aureus (MICs = 1.6-6.3 μg/ml).{47470} Siamycin I inhibits autophosphorylation of the E. faecalis quorum sensing kinase FsrC induced by gelatinase biosynthesis-activating pheromone (GBAP).{47471}
Brand:CaymanSKU:27783 - 500 µgAvailable on backorder
SIB 1553A is an agonist of nicotinic acetylcholine receptors (nAChRs) that displays selectivity for β4 subunit-containing receptors.{33653} Formulations containing SIB 1553A improve attentional function and performance in spatial and non-spatial working memory tasks in animals.{33653,33654,33655}
Brand:CaymanSKU:- SIB 1553A is an agonist of nicotinic acetylcholine receptors (nAChRs) that displays selectivity for β4 subunit-containing receptors.{33653} Formulations containing SIB 1553A improve attentional function and performance in spatial and non-spatial working memory tasks in animals.{33653,33654,33655}
Brand:CaymanSKU:- SIB 1553A is an agonist of nicotinic acetylcholine receptors (nAChRs) that displays selectivity for β4 subunit-containing receptors.{33653} Formulations containing SIB 1553A improve attentional function and performance in spatial and non-spatial working memory tasks in animals.{33653,33654,33655}
Brand:CaymanSKU:- SIB 1553A is an agonist of nicotinic acetylcholine receptors (nAChRs) that displays selectivity for β4 subunit-containing receptors.{33653} Formulations containing SIB 1553A improve attentional function and performance in spatial and non-spatial working memory tasks in animals.{33653,33654,33655}
Brand:CaymanSKU:-
Siccanin is an inhibitor of mitochondrial complex II (succinate dehydrogenase; IC50s = 0.87 and 9.3 μM for P. aeruginosa and rat mitochondria, respectively).{41290} It inhibits the growth of T. mentagrophytes (IC50 = 0.3 μg/ml) via inhibition of succinate oxidation in the mitochondria.{41291} It also inhibits the growth of C. albicans strains with IC50 values ranging from 5-40 and 80-90 μg/ml for aerobic and anaerobic conditions, respectively.{41292}
Brand:CaymanSKU:23654 - 1 mgAvailable on backorder
Siccanin is an inhibitor of mitochondrial complex II (succinate dehydrogenase; IC50s = 0.87 and 9.3 μM for P. aeruginosa and rat mitochondria, respectively).{41290} It inhibits the growth of T. mentagrophytes (IC50 = 0.3 μg/ml) via inhibition of succinate oxidation in the mitochondria.{41291} It also inhibits the growth of C. albicans strains with IC50 values ranging from 5-40 and 80-90 μg/ml for aerobic and anaerobic conditions, respectively.{41292}
Brand:CaymanSKU:23654 - 500 µgAvailable on backorder
SID 3712249 inhibits the biogenesis of microRNA-544 (miR-544), a silencer of mammalian target of rapamycin (mTOR).{54014} Under hypoxic conditions, SID 3712249 (20 nM) increases MTOR mRNA expression and decreases the mRNA expression of the genes encoding miR-544, hypoxia-inducible factor-1α (HIF-1α), and ataxia-telangiectasia mutated kinase (ATM) in MDA-MB-231, MCF-7, and MCF-10A cells. It induces apoptosis in MDA-MB-231 cells in a hypoxia- and mTOR-dependent manner when used at a concentration of 20 nM. SID 3712249 (20 nM) enhances the sensitivity of MCF-7 and MDA-MB-231 cells cultured under hypoxic conditions to decreases in cell viability induced by 5-fluorouracil (5-FU; Item No. 14416). It reduces tumor growth in an MDA-MB-231 mouse xenograft model.
Brand:CaymanSKU:29723 - 10 mgAvailable on backorder
SID 3712249 inhibits the biogenesis of microRNA-544 (miR-544), a silencer of mammalian target of rapamycin (mTOR).{54014} Under hypoxic conditions, SID 3712249 (20 nM) increases MTOR mRNA expression and decreases the mRNA expression of the genes encoding miR-544, hypoxia-inducible factor-1α (HIF-1α), and ataxia-telangiectasia mutated kinase (ATM) in MDA-MB-231, MCF-7, and MCF-10A cells. It induces apoptosis in MDA-MB-231 cells in a hypoxia- and mTOR-dependent manner when used at a concentration of 20 nM. SID 3712249 (20 nM) enhances the sensitivity of MCF-7 and MDA-MB-231 cells cultured under hypoxic conditions to decreases in cell viability induced by 5-fluorouracil (5-FU; Item No. 14416). It reduces tumor growth in an MDA-MB-231 mouse xenograft model.
Brand:CaymanSKU:29723 - 25 mgAvailable on backorder
SID 3712249 inhibits the biogenesis of microRNA-544 (miR-544), a silencer of mammalian target of rapamycin (mTOR).{54014} Under hypoxic conditions, SID 3712249 (20 nM) increases MTOR mRNA expression and decreases the mRNA expression of the genes encoding miR-544, hypoxia-inducible factor-1α (HIF-1α), and ataxia-telangiectasia mutated kinase (ATM) in MDA-MB-231, MCF-7, and MCF-10A cells. It induces apoptosis in MDA-MB-231 cells in a hypoxia- and mTOR-dependent manner when used at a concentration of 20 nM. SID 3712249 (20 nM) enhances the sensitivity of MCF-7 and MDA-MB-231 cells cultured under hypoxic conditions to decreases in cell viability induced by 5-fluorouracil (5-FU; Item No. 14416). It reduces tumor growth in an MDA-MB-231 mouse xenograft model.
Brand:CaymanSKU:29723 - 5 mgAvailable on backorder
SID 3712249 inhibits the biogenesis of microRNA-544 (miR-544), a silencer of mammalian target of rapamycin (mTOR).{54014} Under hypoxic conditions, SID 3712249 (20 nM) increases MTOR mRNA expression and decreases the mRNA expression of the genes encoding miR-544, hypoxia-inducible factor-1α (HIF-1α), and ataxia-telangiectasia mutated kinase (ATM) in MDA-MB-231, MCF-7, and MCF-10A cells. It induces apoptosis in MDA-MB-231 cells in a hypoxia- and mTOR-dependent manner when used at a concentration of 20 nM. SID 3712249 (20 nM) enhances the sensitivity of MCF-7 and MDA-MB-231 cells cultured under hypoxic conditions to decreases in cell viability induced by 5-fluorouracil (5-FU; Item No. 14416). It reduces tumor growth in an MDA-MB-231 mouse xenograft model.
Brand:CaymanSKU:29723 - 50 mgAvailable on backorder
Sildenafil is a potent inhibitor of phosphodiesterase 5 (PDE5) with IC50 values of 3.6 and 3 nM for PDE5 activity in isolated rabbit platelets and human corpus cavernosum, respectively.{21636} It is selective for PDE5 over PDE1 and PDE3 (IC50s = 0.26 and 65 μM, respectively). Sildenafil reverses glucose-induced decreases in angiopoietin 1 (ANG1) expression and reduction of capillary-like tube formation by mouse dermal endothelial cells in vitro and increases the number of functional blood vessels and regional blood flow in the sciatic nerve in a db/db mouse model of diabetic peripheral neuropathy.{42390} It increases the ratio of maximum intracavernosal pressure to mean arterial blood pressure (ICP/MAP), a measure of erectile function, in castrated rats when administered at a dose of 20 mg/kg per day.{42389} Sildenafil (0.5 mg/kg) also reduces cardiac arrest and resuscitation-induced increases in angiotensin II (Item No. 17150), angiotensin converting enzyme (ACE), ACE2, and various angiotensin receptors and increases survival in a porcine model of ischemia/reperfusion injury.{42391} Formulations containing sildenafil have been used in the treatment of erectile dysfunction, pulmonary arterial hypertension, and high-altitude pulmonary edema associated with altitude sickness.
Brand:CaymanSKU:10008671 - 10 mgAvailable on backorder
Sildenafil is a potent inhibitor of phosphodiesterase 5 (PDE5) with IC50 values of 3.6 and 3 nM for PDE5 activity in isolated rabbit platelets and human corpus cavernosum, respectively.{21636} It is selective for PDE5 over PDE1 and PDE3 (IC50s = 0.26 and 65 μM, respectively). Sildenafil reverses glucose-induced decreases in angiopoietin 1 (ANG1) expression and reduction of capillary-like tube formation by mouse dermal endothelial cells in vitro and increases the number of functional blood vessels and regional blood flow in the sciatic nerve in a db/db mouse model of diabetic peripheral neuropathy.{42390} It increases the ratio of maximum intracavernosal pressure to mean arterial blood pressure (ICP/MAP), a measure of erectile function, in castrated rats when administered at a dose of 20 mg/kg per day.{42389} Sildenafil (0.5 mg/kg) also reduces cardiac arrest and resuscitation-induced increases in angiotensin II (Item No. 17150), angiotensin converting enzyme (ACE), ACE2, and various angiotensin receptors and increases survival in a porcine model of ischemia/reperfusion injury.{42391} Formulations containing sildenafil have been used in the treatment of erectile dysfunction, pulmonary arterial hypertension, and high-altitude pulmonary edema associated with altitude sickness.
Brand:CaymanSKU:10008671 - 25 mgAvailable on backorder
Sildenafil is a potent inhibitor of phosphodiesterase 5 (PDE5) with IC50 values of 3.6 and 3 nM for PDE5 activity in isolated rabbit platelets and human corpus cavernosum, respectively.{21636} It is selective for PDE5 over PDE1 and PDE3 (IC50s = 0.26 and 65 μM, respectively). Sildenafil reverses glucose-induced decreases in angiopoietin 1 (ANG1) expression and reduction of capillary-like tube formation by mouse dermal endothelial cells in vitro and increases the number of functional blood vessels and regional blood flow in the sciatic nerve in a db/db mouse model of diabetic peripheral neuropathy.{42390} It increases the ratio of maximum intracavernosal pressure to mean arterial blood pressure (ICP/MAP), a measure of erectile function, in castrated rats when administered at a dose of 20 mg/kg per day.{42389} Sildenafil (0.5 mg/kg) also reduces cardiac arrest and resuscitation-induced increases in angiotensin II (Item No. 17150), angiotensin converting enzyme (ACE), ACE2, and various angiotensin receptors and increases survival in a porcine model of ischemia/reperfusion injury.{42391} Formulations containing sildenafil have been used in the treatment of erectile dysfunction, pulmonary arterial hypertension, and high-altitude pulmonary edema associated with altitude sickness.
Brand:CaymanSKU:10008671 - 50 mgAvailable on backorder
Sildenafil is a potent inhibitor of phosphodiesterase 5 (PDE5) with IC50 values of 3.6 and 3 nM for PDE5 activity in isolated rabbit platelets and human corpus cavernosum, respectively.{21636} It is selective for PDE5 over PDE1 and PDE3 (IC50s = 0.26 and 65 μM, respectively). Sildenafil reverses glucose-induced decreases in angiopoietin 1 (ANG1) expression and reduction of capillary-like tube formation by mouse dermal endothelial cells in vitro and increases the number of functional blood vessels and regional blood flow in the sciatic nerve in a db/db mouse model of diabetic peripheral neuropathy.{42390} It increases the ratio of maximum intracavernosal pressure to mean arterial blood pressure (ICP/MAP), a measure of erectile function, in castrated rats when administered at a dose of 20 mg/kg per day.{42389} Sildenafil (0.5 mg/kg) also reduces cardiac arrest and resuscitation-induced increases in angiotensin II (Item No. 17150), angiotensin converting enzyme (ACE), ACE2, and various angiotensin receptors and increases survival in a porcine model of ischemia/reperfusion injury.{42391} Formulations containing sildenafil have been used in the treatment of erectile dysfunction, pulmonary arterial hypertension, and high-altitude pulmonary edema associated with altitude sickness.
Brand:CaymanSKU:- Sildenafil is a potent inhibitor of phosphodiesterase 5 (PDE5) with IC50 values of 3.6 and 3 nM for PDE5 activity in isolated rabbit platelets and human corpus cavernosum, respectively.{21636} It is selective for PDE5 over PDE1 and PDE3 (IC50s = 0.26 and 65 μM, respectively). Sildenafil reverses glucose-induced decreases in angiopoietin 1 (ANG1) expression and reduction of capillary-like tube formation by mouse dermal endothelial cells in vitro and increases the number of functional blood vessels and regional blood flow in the sciatic nerve in a db/db mouse model of diabetic peripheral neuropathy.{42390} It increases the ratio of maximum intracavernosal pressure to mean arterial blood pressure (ICP/MAP), a measure of erectile function, in castrated rats when administered at a dose of 20 mg/kg per day.{42389} Sildenafil (0.5 mg/kg) also reduces cardiac arrest and resuscitation-induced increases in angiotensin II (Item No. 17150), angiotensin converting enzyme (ACE), ACE2, and various angiotensin receptors and increases survival in a porcine model of ischemia/reperfusion injury.{42391} Formulations containing sildenafil have been used in the treatment of erectile dysfunction, pulmonary arterial hypertension, and high-altitude pulmonary edema associated with altitude sickness.
Brand:CaymanSKU:- Sildenafil is a potent inhibitor of phosphodiesterase 5 (PDE5) with IC50 values of 3.6 and 3 nM for PDE5 activity in isolated rabbit platelets and human corpus cavernosum, respectively.{21636} It is selective for PDE5 over PDE1 and PDE3 (IC50s = 0.26 and 65 μM, respectively). Sildenafil reverses glucose-induced decreases in angiopoietin 1 (ANG1) expression and reduction of capillary-like tube formation by mouse dermal endothelial cells in vitro and increases the number of functional blood vessels and regional blood flow in the sciatic nerve in a db/db mouse model of diabetic peripheral neuropathy.{42390} It increases the ratio of maximum intracavernosal pressure to mean arterial blood pressure (ICP/MAP), a measure of erectile function, in castrated rats when administered at a dose of 20 mg/kg per day.{42389} Sildenafil (0.5 mg/kg) also reduces cardiac arrest and resuscitation-induced increases in angiotensin II (Item No. 17150), angiotensin converting enzyme (ACE), ACE2, and various angiotensin receptors and increases survival in a porcine model of ischemia/reperfusion injury.{42391} Formulations containing sildenafil have been used in the treatment of erectile dysfunction, pulmonary arterial hypertension, and high-altitude pulmonary edema associated with altitude sickness.
Brand:CaymanSKU:-
Sildenafil-d3 is intended for use as an internal standard for the quantification of sildenafil (Item Nos. 10008671 | 14008) by GC- or LC-MS. Sildenafil is a potent inhibitor of phosphodiesterase 5 (PDE5) with IC50 values of 3.6 and 3 nM for PDE5 activity in isolated rabbit platelets and human corpus cavernosum, respectively.{21636} It is selective for PDE5 over PDE1 and PDE3 (IC50s = 0.26 and 65 μM, respectively). Sildenafil reverses glucose-induced decreases in angiopoietin 1 (Ang1) expression and reduction of capillary-like tube formation by mouse dermal endothelial cells in vitro and increases the number of functional blood vessels and regional blood flow in the sciatic nerve in a db/db mouse model of diabetic peripheral neuropathy.{42390} It increases the ratio of maximum intracavernosal pressure to mean arterial blood pressure (ICP/MAP), a measure of erectile function, in castrated rats when administered at a dose of 20 mg/kg per day.{42389} Sildenafil (0.5 mg/kg) also reduces cardiac arrest and resuscitation-induced increases in angiotensin II (Item No. 17150), angiotensin converting enzyme (ACE), ACE2, and various angiotensin receptors and increases survival in a porcine model of ischemia/reperfusion injury.{42391} Formulations containing sildenafil have been used in the treatment of erectile dysfunction, pulmonary arterial hypertension, and high-altitude pulmonary edema associated with altitude sickness.
Brand:CaymanSKU:-Available on backorder
Sildenafil-d3 is intended for use as an internal standard for the quantification of sildenafil (Item Nos. 10008671 | 14008) by GC- or LC-MS. Sildenafil is a potent inhibitor of phosphodiesterase 5 (PDE5) with IC50 values of 3.6 and 3 nM for PDE5 activity in isolated rabbit platelets and human corpus cavernosum, respectively.{21636} It is selective for PDE5 over PDE1 and PDE3 (IC50s = 0.26 and 65 μM, respectively). Sildenafil reverses glucose-induced decreases in angiopoietin 1 (Ang1) expression and reduction of capillary-like tube formation by mouse dermal endothelial cells in vitro and increases the number of functional blood vessels and regional blood flow in the sciatic nerve in a db/db mouse model of diabetic peripheral neuropathy.{42390} It increases the ratio of maximum intracavernosal pressure to mean arterial blood pressure (ICP/MAP), a measure of erectile function, in castrated rats when administered at a dose of 20 mg/kg per day.{42389} Sildenafil (0.5 mg/kg) also reduces cardiac arrest and resuscitation-induced increases in angiotensin II (Item No. 17150), angiotensin converting enzyme (ACE), ACE2, and various angiotensin receptors and increases survival in a porcine model of ischemia/reperfusion injury.{42391} Formulations containing sildenafil have been used in the treatment of erectile dysfunction, pulmonary arterial hypertension, and high-altitude pulmonary edema associated with altitude sickness.
Brand:CaymanSKU:-Available on backorder
Silodosin is a potent α1A-adrenoceptor antagonist (Ki = 0.036 nM).{25007,25008} It shows selectivity for the prostatic adrenoceptor.{25007,25005} As a result, it is effective against lower urinary tract symptoms associated with benign prostatic hyperplasia.{25009,25006}
Brand:CaymanSKU:- Silodosin is a potent α1A-adrenoceptor antagonist (Ki = 0.036 nM).{25007,25008} It shows selectivity for the prostatic adrenoceptor.{25007,25005} As a result, it is effective against lower urinary tract symptoms associated with benign prostatic hyperplasia.{25009,25006}
Brand:CaymanSKU:- Silodosin is a potent α1A-adrenoceptor antagonist (Ki = 0.036 nM).{25007,25008} It shows selectivity for the prostatic adrenoceptor.{25007,25005} As a result, it is effective against lower urinary tract symptoms associated with benign prostatic hyperplasia.{25009,25006}
Brand:CaymanSKU:- Silodosin is a potent α1A-adrenoceptor antagonist (Ki = 0.036 nM).{25007,25008} It shows selectivity for the prostatic adrenoceptor.{25007,25005} As a result, it is effective against lower urinary tract symptoms associated with benign prostatic hyperplasia.{25009,25006}
Brand:CaymanSKU:-
Silodosin glucuronide is an active metabolite of the α1A-adrenergic receptor antagonist silodosin (Item No. 14866).{43909,43910} It is formed from silodosin by the UDP-glucuronosyltransferase (UGT) isoform UGT2B7.{43909} Silodosin glucuronide is toxic to rats with an LD50 value of 0.347 mg/kg.{43910}
Brand:CaymanSKU:28045 - 500 µgAvailable on backorder
Silodosin-d4 is intended for use as an internal standard for the quantification of silodosin (Item No. 14866) by GC- or LC-MS. Silodosin is an α1A-adrenergic receptor (α1A-AR) antagonist (Ki = 0.036 nM).{25007} It is 583- and 56-fold selective for α1A- over α1B- and α1D-ARs, respectively. Silodosin inhibits phenylephrine-induced contraction of isolated rabbit prostate (pA2 = 10.05) more potently than rabbit or rat aorta (pA2s = 9.36 and 8.13, respectively).{55032} It inhibits norepinephrine-induced contraction of isolated human prostate tissue when used at concentrations ranging from 0.3 to 10 nM.{25007} Silodosin (0.01-1,000 µg/kg) inhibits phenylephrine-induced increases in intraurethral pressure in rats.{25005} Formulations containing silodosin have been used in the treatment of benign prostatic hyperplasia.
Brand:CaymanSKU:30236 - 1 mgAvailable on backorder
Silybin is the major flavonolignan found in milk thistle (S. marianum).{12584} It inhibits wild mushroom tyrosinase (IC50 = 1.7 μM).{46261} Silybin scavenges superoxide radicals (IC50 = 55.2 μM) and inhibits lipid peroxidation in vitro (IC50 = 73.92 μM).{46262}
Brand:CaymanSKU:10006211 - 1 gAvailable on backorder
Silybin is the major flavonolignan found in milk thistle (S. marianum).{12584} It inhibits wild mushroom tyrosinase (IC50 = 1.7 μM).{46261} Silybin scavenges superoxide radicals (IC50 = 55.2 μM) and inhibits lipid peroxidation in vitro (IC50 = 73.92 μM).{46262}
Brand:CaymanSKU:10006211 - 10 gAvailable on backorder
Silybin is the major flavonolignan found in milk thistle (S. marianum).{12584} It inhibits wild mushroom tyrosinase (IC50 = 1.7 μM).{46261} Silybin scavenges superoxide radicals (IC50 = 55.2 μM) and inhibits lipid peroxidation in vitro (IC50 = 73.92 μM).{46262}
Brand:CaymanSKU:10006211 - 5 gAvailable on backorder
Silybin is the major flavonolignan found in milk thistle (S. marianum).{12584} It inhibits wild mushroom tyrosinase (IC50 = 1.7 μM).{46261} Silybin scavenges superoxide radicals (IC50 = 55.2 μM) and inhibits lipid peroxidation in vitro (IC50 = 73.92 μM).{46262}
Brand:CaymanSKU:10006211 - 50 gAvailable on backorder
Simeprevir is an orally bioavailable and potent inhibitor of the hepatitis C virus (HCV) nonstructural protein 3/4A (NS3/4A) protease (Ki = 0.36 nM), a serine protease essential for HCV replication.{38234} It inhibits HCV viral replication with an EC50 value of 7.8 nM in Huh7 replicon cells using a luciferase-based assay. Simeprevir is effective against the HCV genotypes 1a and 1b in biochemical assays.{38233} In Huh7 replicon cells, it is synergistically effective when used in combination with IFN-α or NM-107 and has an additive effect when used with ribavirin (Item No. 16757). Formulations containing simeprevir have been used, alone or in combination with pegylated IFN-α and ribavirin, for the treatment of HCV.
Brand:CaymanSKU:22144 -Out of stock
Simeprevir is an orally bioavailable and potent inhibitor of the hepatitis C virus (HCV) nonstructural protein 3/4A (NS3/4A) protease (Ki = 0.36 nM), a serine protease essential for HCV replication.{38234} It inhibits HCV viral replication with an EC50 value of 7.8 nM in Huh7 replicon cells using a luciferase-based assay. Simeprevir is effective against the HCV genotypes 1a and 1b in biochemical assays.{38233} In Huh7 replicon cells, it is synergistically effective when used in combination with IFN-α or NM-107 and has an additive effect when used with ribavirin (Item No. 16757). Formulations containing simeprevir have been used, alone or in combination with pegylated IFN-α and ribavirin, for the treatment of HCV.
Brand:CaymanSKU:22144 -Out of stock
Simeprevir is an orally bioavailable and potent inhibitor of the hepatitis C virus (HCV) nonstructural protein 3/4A (NS3/4A) protease (Ki = 0.36 nM), a serine protease essential for HCV replication.{38234} It inhibits HCV viral replication with an EC50 value of 7.8 nM in Huh7 replicon cells using a luciferase-based assay. Simeprevir is effective against the HCV genotypes 1a and 1b in biochemical assays.{38233} In Huh7 replicon cells, it is synergistically effective when used in combination with IFN-α or NM-107 and has an additive effect when used with ribavirin (Item No. 16757). Formulations containing simeprevir have been used, alone or in combination with pegylated IFN-α and ribavirin, for the treatment of HCV.
Brand:CaymanSKU:22144 -Out of stock
Simeprevir is an orally bioavailable and potent inhibitor of the hepatitis C virus (HCV) nonstructural protein 3/4A (NS3/4A) protease (Ki = 0.36 nM), a serine protease essential for HCV replication.{38234} It inhibits HCV viral replication with an EC50 value of 7.8 nM in Huh7 replicon cells using a luciferase-based assay. Simeprevir is effective against the HCV genotypes 1a and 1b in biochemical assays.{38233} In Huh7 replicon cells, it is synergistically effective when used in combination with IFN-α or NM-107 and has an additive effect when used with ribavirin (Item No. 16757). Formulations containing simeprevir have been used, alone or in combination with pegylated IFN-α and ribavirin, for the treatment of HCV.
Brand:CaymanSKU:22144 -Out of stock
Simetryn is a triazine herbicide that is primarily used to control broad-leaved weeds and grass in paddy rice and other crops.{34066} It is absorbed through roots and foliage and inhibits photosynthesis.{34063} Like other triazine herbicides, simetryn is characterized by high persistence and toxicity.{34066,34067}
Brand:CaymanSKU:20392 -Available on backorder
Simvastatin is a competitive inhibitor of HMG-CoA reductase with a Ki value of 0.12 nM for the hydrolyzed, open ring form of the molecule.{15312} After 18 days of treatment with simvastatin in dogs at a dose of 8 mg/kg/day, plasma cholesterol levels were reduced by 33%.{15310} Simvastatin also suppresses TNF-induced NF-κB activation (IC50 ~ 13 µM), which potentiates apoptosis in human myeloid leukemia cells and thus may be useful in treating cancer.{15363} Clinical formulations containing simvastatin are used in combination with ezetimibe to treat dyslipidemia.
Brand:CaymanSKU:10010344 - 100 mgAvailable on backorder
Simvastatin is a competitive inhibitor of HMG-CoA reductase with a Ki value of 0.12 nM for the hydrolyzed, open ring form of the molecule.{15312} After 18 days of treatment with simvastatin in dogs at a dose of 8 mg/kg/day, plasma cholesterol levels were reduced by 33%.{15310} Simvastatin also suppresses TNF-induced NF-κB activation (IC50 ~ 13 µM), which potentiates apoptosis in human myeloid leukemia cells and thus may be useful in treating cancer.{15363} Clinical formulations containing simvastatin are used in combination with ezetimibe to treat dyslipidemia.
Brand:CaymanSKU:10010344 - 25 mgAvailable on backorder
Simvastatin is a competitive inhibitor of HMG-CoA reductase with a Ki value of 0.12 nM for the hydrolyzed, open ring form of the molecule.{15312} After 18 days of treatment with simvastatin in dogs at a dose of 8 mg/kg/day, plasma cholesterol levels were reduced by 33%.{15310} Simvastatin also suppresses TNF-induced NF-κB activation (IC50 ~ 13 µM), which potentiates apoptosis in human myeloid leukemia cells and thus may be useful in treating cancer.{15363} Clinical formulations containing simvastatin are used in combination with ezetimibe to treat dyslipidemia.
Brand:CaymanSKU:10010344 - 5 mgAvailable on backorder
Simvastatin is a competitive inhibitor of HMG-CoA reductase with a Ki value of 0.12 nM for the hydrolyzed, open ring form of the molecule.{15312} After 18 days of treatment with simvastatin in dogs at a dose of 8 mg/kg/day, plasma cholesterol levels were reduced by 33%.{15310} Simvastatin also suppresses TNF-induced NF-κB activation (IC50 ~ 13 µM), which potentiates apoptosis in human myeloid leukemia cells and thus may be useful in treating cancer.{15363} Clinical formulations containing simvastatin are used in combination with ezetimibe to treat dyslipidemia.
Brand:CaymanSKU:10010344 - 50 mgAvailable on backorder
Simvastatin is a competitive inhibitor of HMG-CoA reductase with a Ki value of 0.12 nM for the hydrolyzed, open ring form of the molecule.{15312} After 18 days of treatment with simvastatin in dogs at a dose of 8 mg/kg/day, plasma cholesterol levels were reduced by 33%.{15310} Simvastatin also suppresses TNF-induced NF-κB activation (IC50 ~ 13 µM), which potentiates apoptosis in human myeloid leukemia cells and thus may be useful in treating cancer.{15363} Clinical formulations containing simvastatin are used in combination with ezetimibe to treat dyslipidemia.
Brand:CaymanSKU:10010345 - 1 mgAvailable on backorder
Simvastatin is a competitive inhibitor of HMG-CoA reductase with a Ki value of 0.12 nM for the hydrolyzed, open ring form of the molecule.{15312} After 18 days of treatment with simvastatin in dogs at a dose of 8 mg/kg/day, plasma cholesterol levels were reduced by 33%.{15310} Simvastatin also suppresses TNF-induced NF-κB activation (IC50 ~ 13 µM), which potentiates apoptosis in human myeloid leukemia cells and thus may be useful in treating cancer.{15363} Clinical formulations containing simvastatin are used in combination with ezetimibe to treat dyslipidemia.
Brand:CaymanSKU:10010345 - 10 mgAvailable on backorder
Simvastatin is a competitive inhibitor of HMG-CoA reductase with a Ki value of 0.12 nM for the hydrolyzed, open ring form of the molecule.{15312} After 18 days of treatment with simvastatin in dogs at a dose of 8 mg/kg/day, plasma cholesterol levels were reduced by 33%.{15310} Simvastatin also suppresses TNF-induced NF-κB activation (IC50 ~ 13 µM), which potentiates apoptosis in human myeloid leukemia cells and thus may be useful in treating cancer.{15363} Clinical formulations containing simvastatin are used in combination with ezetimibe to treat dyslipidemia.
Brand:CaymanSKU:10010345 - 25 mgAvailable on backorder
Simvastatin is a competitive inhibitor of HMG-CoA reductase with a Ki value of 0.12 nM for the hydrolyzed, open ring form of the molecule.{15312} After 18 days of treatment with simvastatin in dogs at a dose of 8 mg/kg/day, plasma cholesterol levels were reduced by 33%.{15310} Simvastatin also suppresses TNF-induced NF-κB activation (IC50 ~ 13 µM), which potentiates apoptosis in human myeloid leukemia cells and thus may be useful in treating cancer.{15363} Clinical formulations containing simvastatin are used in combination with ezetimibe to treat dyslipidemia.
Brand:CaymanSKU:10010345 - 5 mgAvailable on backorder
Simvastatin-d6 contains six deuterium atoms located on the methyl groups. It is intended for use as an internal standard for the quantification of simvastatin (Item No. 10010344) by GC- or LC-MS. Simvastatin is a competitive inhibitor of HMG-CoA reductase with a Ki value of 0.12 nM for the hydrolyzed, open ring form of the molecule.{15312} After 18 days of treatment with simvastatin in dogs at a dose of 8 mg/kg per day, plasma cholesterol levels were reduced by 33%.{15310} Simvastatin also suppresses TNF-induced NF-κB activation (IC50 ~ 13 µM), which potentiates apoptosis in human myeloid leukemia cells and thus may be useful in treating cancer.{15363}
Brand:CaymanSKU:22181 -Out of stock
Simvastatin-d6 contains six deuterium atoms located on the methyl groups. It is intended for use as an internal standard for the quantification of simvastatin (Item No. 10010344) by GC- or LC-MS. Simvastatin is a competitive inhibitor of HMG-CoA reductase with a Ki value of 0.12 nM for the hydrolyzed, open ring form of the molecule.{15312} After 18 days of treatment with simvastatin in dogs at a dose of 8 mg/kg per day, plasma cholesterol levels were reduced by 33%.{15310} Simvastatin also suppresses TNF-induced NF-κB activation (IC50 ~ 13 µM), which potentiates apoptosis in human myeloid leukemia cells and thus may be useful in treating cancer.{15363}
Brand:CaymanSKU:22181 -Out of stock
Simvastatin-d6 contains six deuterium atoms located on the methyl groups. It is intended for use as an internal standard for the quantification of simvastatin (Item No. 10010344) by GC- or LC-MS. Simvastatin is a competitive inhibitor of HMG-CoA reductase with a Ki value of 0.12 nM for the hydrolyzed, open ring form of the molecule.{15312} After 18 days of treatment with simvastatin in dogs at a dose of 8 mg/kg per day, plasma cholesterol levels were reduced by 33%.{15310} Simvastatin also suppresses TNF-induced NF-κB activation (IC50 ~ 13 µM), which potentiates apoptosis in human myeloid leukemia cells and thus may be useful in treating cancer.{15363}
Brand:CaymanSKU:22181 -Out of stock
Simvastatin-d6 contains six deuterium atoms located on the methyl groups. It is intended for use as an internal standard for the quantification of simvastatin (Item No. 10010344) by GC- or LC-MS. Simvastatin is a competitive inhibitor of HMG-CoA reductase with a Ki value of 0.12 nM for the hydrolyzed, open ring form of the molecule.{15312} After 18 days of treatment with simvastatin in dogs at a dose of 8 mg/kg per day, plasma cholesterol levels were reduced by 33%.{15310} Simvastatin also suppresses TNF-induced NF-κB activation (IC50 ~ 13 µM), which potentiates apoptosis in human myeloid leukemia cells and thus may be useful in treating cancer.{15363}
Brand:CaymanSKU:22181 -Out of stock
As the active metabolite of molsidomine, SIN-1 (chloride) is a potent vasorelaxant and inhibitor of platelet aggregation. It produces both NO and superoxide and can therefore be used to generate peroxynitrite under physiological conditions.{3222,6435,4159}
Brand:CaymanSKU:82220 - 10 mgAvailable on backorder
As the active metabolite of molsidomine, SIN-1 (chloride) is a potent vasorelaxant and inhibitor of platelet aggregation. It produces both NO and superoxide and can therefore be used to generate peroxynitrite under physiological conditions.{3222,6435,4159}
Brand:CaymanSKU:82220 - 100 mgAvailable on backorder
As the active metabolite of molsidomine, SIN-1 (chloride) is a potent vasorelaxant and inhibitor of platelet aggregation. It produces both NO and superoxide and can therefore be used to generate peroxynitrite under physiological conditions.{3222,6435,4159}
Brand:CaymanSKU:82220 - 50 mgAvailable on backorder
As the active metabolite of molsidomine, SIN-1 (chloride) is a potent vasorelaxant and inhibitor of platelet aggregation. It produces both NO and superoxide and can therefore be used to generate peroxynitrite under physiological conditions.{3222,6435,4159}
Brand:CaymanSKU:82220 - 500 mgAvailable on backorder
Sinapic acid is a phenylpropanoid hydroxycinnamic acid with diverse biological activities.{39903} Sinapic acid inhibits collagen-induced human platelet aggregation by up to 70% in vitro (IC50 = 1.03 mM).{39905} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) and 2,2′-azino-bis-(3-ethylbenzothiazoline-6-sulfonate) (ABTS) free radicals with IC50 values of 8.3 and 5.4 μg/ml, respectively.{30137} Sinapic acid (200 μM) reduces colony formation of SW480 human colon carcinoma cells by 4-fold.{39906} It also inhibits colony formation of E. coli, S. enteritidis, and S. aureus on agar (MICs = 2.2, 2, and 1.8 mM, respectively).{39907} In vivo, sinapic acid (4 mg/kg, p.o.) increases the time spent in the open arms of the elevated plus maze by approximately 15% in mice, an effect that can be blocked by the GABAA receptor antagonists flumazenil (Item No. 14252) and bicuculline (Item No. 11727).{39903} Sinapic acid is also commonly used as a matrix in protein mass spectrometry.{39904}
Brand:CaymanSKU:25457 - 1 gAvailable on backorder
Sinapic acid is a phenylpropanoid hydroxycinnamic acid with diverse biological activities.{39903} Sinapic acid inhibits collagen-induced human platelet aggregation by up to 70% in vitro (IC50 = 1.03 mM).{39905} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) and 2,2′-azino-bis-(3-ethylbenzothiazoline-6-sulfonate) (ABTS) free radicals with IC50 values of 8.3 and 5.4 μg/ml, respectively.{30137} Sinapic acid (200 μM) reduces colony formation of SW480 human colon carcinoma cells by 4-fold.{39906} It also inhibits colony formation of E. coli, S. enteritidis, and S. aureus on agar (MICs = 2.2, 2, and 1.8 mM, respectively).{39907} In vivo, sinapic acid (4 mg/kg, p.o.) increases the time spent in the open arms of the elevated plus maze by approximately 15% in mice, an effect that can be blocked by the GABAA receptor antagonists flumazenil (Item No. 14252) and bicuculline (Item No. 11727).{39903} Sinapic acid is also commonly used as a matrix in protein mass spectrometry.{39904}
Brand:CaymanSKU:25457 - 10 gAvailable on backorder
Sinapic acid is a phenylpropanoid hydroxycinnamic acid with diverse biological activities.{39903} Sinapic acid inhibits collagen-induced human platelet aggregation by up to 70% in vitro (IC50 = 1.03 mM).{39905} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) and 2,2′-azino-bis-(3-ethylbenzothiazoline-6-sulfonate) (ABTS) free radicals with IC50 values of 8.3 and 5.4 μg/ml, respectively.{30137} Sinapic acid (200 μM) reduces colony formation of SW480 human colon carcinoma cells by 4-fold.{39906} It also inhibits colony formation of E. coli, S. enteritidis, and S. aureus on agar (MICs = 2.2, 2, and 1.8 mM, respectively).{39907} In vivo, sinapic acid (4 mg/kg, p.o.) increases the time spent in the open arms of the elevated plus maze by approximately 15% in mice, an effect that can be blocked by the GABAA receptor antagonists flumazenil (Item No. 14252) and bicuculline (Item No. 11727).{39903} Sinapic acid is also commonly used as a matrix in protein mass spectrometry.{39904}
Brand:CaymanSKU:25457 - 25 gAvailable on backorder
Sinapic acid is a phenylpropanoid hydroxycinnamic acid with diverse biological activities.{39903} Sinapic acid inhibits collagen-induced human platelet aggregation by up to 70% in vitro (IC50 = 1.03 mM).{39905} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) and 2,2′-azino-bis-(3-ethylbenzothiazoline-6-sulfonate) (ABTS) free radicals with IC50 values of 8.3 and 5.4 μg/ml, respectively.{30137} Sinapic acid (200 μM) reduces colony formation of SW480 human colon carcinoma cells by 4-fold.{39906} It also inhibits colony formation of E. coli, S. enteritidis, and S. aureus on agar (MICs = 2.2, 2, and 1.8 mM, respectively).{39907} In vivo, sinapic acid (4 mg/kg, p.o.) increases the time spent in the open arms of the elevated plus maze by approximately 15% in mice, an effect that can be blocked by the GABAA receptor antagonists flumazenil (Item No. 14252) and bicuculline (Item No. 11727).{39903} Sinapic acid is also commonly used as a matrix in protein mass spectrometry.{39904}
Brand:CaymanSKU:25457 - 5 gAvailable on backorder
Sinefungin is a nucleoside structurally related to S-adenosylhomocysteine (Item No. 13603) and S-adenosylmethionine (Item No. 13956) that was originally isolated from Streptomyces.{18391,18646} While it has limited use as an antibiotic due to its high in vivo toxicity, sinefungin has proved useful as a non-selective inhibitor of SET domain-containing methyltransferases in the study of epigenetic regulation (IC50 values range from 0.1-20 μM).{16624,18398,24147,18480,19368}
Brand:CaymanSKU:- Sinefungin is a nucleoside structurally related to S-adenosylhomocysteine (Item No. 13603) and S-adenosylmethionine (Item No. 13956) that was originally isolated from Streptomyces.{18391,18646} While it has limited use as an antibiotic due to its high in vivo toxicity, sinefungin has proved useful as a non-selective inhibitor of SET domain-containing methyltransferases in the study of epigenetic regulation (IC50 values range from 0.1-20 μM).{16624,18398,24147,18480,19368}
Brand:CaymanSKU:- Sinefungin is a nucleoside structurally related to S-adenosylhomocysteine (Item No. 13603) and S-adenosylmethionine (Item No. 13956) that was originally isolated from Streptomyces.{18391,18646} While it has limited use as an antibiotic due to its high in vivo toxicity, sinefungin has proved useful as a non-selective inhibitor of SET domain-containing methyltransferases in the study of epigenetic regulation (IC50 values range from 0.1-20 μM).{16624,18398,24147,18480,19368}
Brand:CaymanSKU:-
Sinensetin is a polymethoxylated flavone that is present in the Southeast Asian medical plant O. stamineus, as well as in orange oil. It has been shown to enhance adipogenesis and lipolysis by increasing cAMP levels in 3T3-L1 cells.{31727} Sinensetin is also reported to inhibit α-glucosidase and α-amylase activity in vitro, indicating its potential usefulness in the control of glucose absorption.{31728} Additionally, sinensetin has been shown to suppress the expression of genes associated with inflammation by regulating IκBα protein levels in LPS-activated macrophages.{31729}
Brand:CaymanSKU:19751 -Available on backorder
Sinensetin is a polymethoxylated flavone that is present in the Southeast Asian medical plant O. stamineus, as well as in orange oil. It has been shown to enhance adipogenesis and lipolysis by increasing cAMP levels in 3T3-L1 cells.{31727} Sinensetin is also reported to inhibit α-glucosidase and α-amylase activity in vitro, indicating its potential usefulness in the control of glucose absorption.{31728} Additionally, sinensetin has been shown to suppress the expression of genes associated with inflammation by regulating IκBα protein levels in LPS-activated macrophages.{31729}
Brand:CaymanSKU:19751 -Available on backorder
Sinensetin is a polymethoxylated flavone that is present in the Southeast Asian medical plant O. stamineus, as well as in orange oil. It has been shown to enhance adipogenesis and lipolysis by increasing cAMP levels in 3T3-L1 cells.{31727} Sinensetin is also reported to inhibit α-glucosidase and α-amylase activity in vitro, indicating its potential usefulness in the control of glucose absorption.{31728} Additionally, sinensetin has been shown to suppress the expression of genes associated with inflammation by regulating IκBα protein levels in LPS-activated macrophages.{31729}
Brand:CaymanSKU:19751 -Available on backorder
Key Features Specially formulated Single-Use Arachidonic Acid (peroxide free) for use in cell culture or other in vitro experiments Peroxide free and sealed under argon to maintain product integrity Each pack contains 10 single-use ampules (>1 ml fatty acid at 500 µg/ml in ethanol) Single-use arachidonic acid (peroxide free) consists of 10 sealed ampules, each containing >1 ml of ethanolic solution of fatty acid at a concentration of 500 µg/ml. Peroxides were removed by silicic acid chromatography. The headspace in each ampule is purged with argon. Single-use polyunsaturated fatty acids (PUFAs) are intended for analytical and research applications where absence of oxidized adducts is desired. Ampules have been optimized for one-time use. For best results, use promptly after opening. Arachidonic acid (Item No. 90010) is a substrate for the biosynthesis of eicosanoid second messengers. PUFAs, including arachidonic acid, oxidize spontaneously on exposure to room air, yielding a complex mixture of fatty acid peroxides. Oxidation of PUFAs can be particularly problematic in samples stored in capped vials for prolonged periods, even at low temperatures. These single-use ampules are designed to circumvent this issue.
Brand:CaymanSKU:-Available on backorder
Key Features Specially formulated Single-Use Docosahexaenoic Acid (peroxide free) for use in cell culture or other in vitro experiments Peroxide free and sealed under argon to maintain product integrity Each pack contains 10 single-use ampules (>1 ml fatty acid at 500 µg/ml in ethanol) Single-use docosahexaenoic acid (peroxide free) consists of 10 sealed ampules, each containing >1 ml of ethanolic solution of fatty acid at a concentration of 500 µg/ml. Peroxides were removed by silicic acid chromatography. The headspace in each ampule is purged with argon. Single-use polyunsaturated fatty acids (PUFAs) are intended for analytical and research applications where absence of oxidized adducts is desired. Ampules have been optimized for one-time use. For best results, use promptly after opening. Docosahexaenoic acid (Item No. 90310) is an essential fatty acid and the most abundant ω-3 fatty acid in neural tissues, especially in the retina and brain. PUFAs, including docosahexaenoic acid, oxidize spontaneously on exposure to room air, yielding a complex mixture of fatty acid peroxides. Oxidation of PUFAs can be particularly problematic in samples stored in capped vials for prolonged periods, even at low temperatures. These single-use ampules are designed to circumvent this issue.
Brand:CaymanSKU:-Available on backorder
Key Features Specially formulated Single-Use Eicosapentaenoic Acid (peroxide free) for use in cell culture or other in vitro experiments Peroxide free and sealed under argon to maintain product integrity Each pack contains 10 single-use ampules (>1 ml fatty acid at 500 µg/ml in ethanol) Single-use eicosapentaenoic (peroxide free) consists of 10 sealed ampules, each containing >1 ml of ethanolic solution of fatty acid at a concentration of 500 µg/ml. Peroxides were removed by silicic acid chromatography. The headspace in each ampule is purged with argon. Single-use polyunsaturated fatty acids (PUFAs) are intended for analytical and research applications where absence of oxidized adducts is desired. Ampules have been optimized for one-time use. For best results, use promptly after opening. Eicosapentaenoic acid (Item No. 90110) is an ω-3 fatty acid abundantly available in marine organisms. PUFAs, including eicosapentaenoic acid, oxidize spontaneously on exposure to room air, yielding a complex mixture of fatty acid peroxides. Oxidation of PUFAs can be particularly problematic in samples stored in capped vials for prolonged periods, even at low temperatures. These single-use ampules are designed to circumvent this issue.
Brand:CaymanSKU:-Available on backorder
Key Features Specially formulated Single-Use Linoleic Acid (peroxide free) for use in cell culture or other in vitro experiments Peroxide free and sealed under argon to maintain product integrity Each pack contains 10 single-use ampules (>1 ml fatty acid at 500 µg/ml in ethanol) Single-use linoleic acid (peroxide free) consists of 10 sealed ampules, each containing >1 ml of ethanolic solution of fatty acid at a concentration of 500 µg/ml. Peroxides were removed by silicic acid chromatography. The headspace in each ampule is purged with argon. Single-use polyunsaturated fatty acids (PUFAs) are intended for analytical and research applications where absence of oxidized adducts is desired. Ampules have been optimized for one-time use. For best results, use promptly after opening. Linoleic acid (Item No. 90150) is a PUFA that is prevalent in the western diet. PUFAs, including linoleic acid, oxidize spontaneously on exposure to room air, yielding a complex mixture of fatty acid peroxides. Oxidation of PUFAs can be particularly problematic in samples stored in capped vials for prolonged periods, even at low temperatures. These single-use ampules are designed to circumvent this issue.
Brand:CaymanSKU:-Available on backorder
Sinomenine is a natural plant alkaloid commonly used to alleviate inflammation associated with rheumatoid arthritis.{26557} It activates histamine release, reduces joint stiffness and pain, and alters cytokine generation without producing gastrointestinal adverse events.{26557,26555,26556,26558} Sinomenine also impairs signaling through NF-κB, resulting in immunosuppression as well as reduced inflammation and pain.{26556,26557} It enhances the bioavailability of some compounds, at least in part through an inhibition of drug export by transporters like P-glycoprotein.{26559,26554}
Brand:CaymanSKU:- Sinomenine is a natural plant alkaloid commonly used to alleviate inflammation associated with rheumatoid arthritis.{26557} It activates histamine release, reduces joint stiffness and pain, and alters cytokine generation without producing gastrointestinal adverse events.{26557,26555,26556,26558} Sinomenine also impairs signaling through NF-κB, resulting in immunosuppression as well as reduced inflammation and pain.{26556,26557} It enhances the bioavailability of some compounds, at least in part through an inhibition of drug export by transporters like P-glycoprotein.{26559,26554}
Brand:CaymanSKU:- Sinomenine is a natural plant alkaloid commonly used to alleviate inflammation associated with rheumatoid arthritis.{26557} It activates histamine release, reduces joint stiffness and pain, and alters cytokine generation without producing gastrointestinal adverse events.{26557,26555,26556,26558} Sinomenine also impairs signaling through NF-κB, resulting in immunosuppression as well as reduced inflammation and pain.{26556,26557} It enhances the bioavailability of some compounds, at least in part through an inhibition of drug export by transporters like P-glycoprotein.{26559,26554}
Brand:CaymanSKU:-
The mammalian transcription factor forkhead box M1 (FoxM1) is induced during G1 phase, with expression continuing through S phase and mitosis. Siomycin A is a peptide thiazole antibiotic, first isolated from S. sioyaensis, that interacts with the 23S rRNA of bacteria.{24927} It inhibits FoxM1 (IC50 = ~5 μM), preventing the expression of FoxM1-regulated genes, which includes FoxM1 itself.{24928,24931} Through this mechanism, siomycin A prevents proliferation and induces apoptosis in certain types of stem cells as well as cancer cells.{24930,24926,24929}
Brand:CaymanSKU:-