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SCIO 469 is a p38 MAPK inhibitor (IC50 = 9 nM for p38α).{48745} It is 10-fold selective for p38α over p38β MAPK and 2,000-fold selective over a panel of 20 additional kinases. SCIO 469 inhibits secretion of IL-6 from multiple myeloma patient-derived bone marrow stromal cells (BMSCs) in a concentration-dependent manner. It increases growth inhibition, DNA fragmentation, and caspase-8 and PARP cleavage induced by the proteasome inhibitor PS-341 (bortezomib; Item No. 10008822) in MM.1S cells when used at concentrations of 100 and 200 nM. SCIO 469 (150 and 450 mg/kg) reduces microvessel density and tumor load and increases survival in a 5T33MM murine myeloma model.{48746}
Brand:CaymanSKU:29484 - 10 mgAvailable on backorder
SCIO 469 is a p38 MAPK inhibitor (IC50 = 9 nM for p38α).{48745} It is 10-fold selective for p38α over p38β MAPK and 2,000-fold selective over a panel of 20 additional kinases. SCIO 469 inhibits secretion of IL-6 from multiple myeloma patient-derived bone marrow stromal cells (BMSCs) in a concentration-dependent manner. It increases growth inhibition, DNA fragmentation, and caspase-8 and PARP cleavage induced by the proteasome inhibitor PS-341 (bortezomib; Item No. 10008822) in MM.1S cells when used at concentrations of 100 and 200 nM. SCIO 469 (150 and 450 mg/kg) reduces microvessel density and tumor load and increases survival in a 5T33MM murine myeloma model.{48746}
Brand:CaymanSKU:29484 - 5 mgAvailable on backorder
Sclareol is a diterpene originally isolated from S. sclarea and has diverse biological activities.{53621,53622,53623} It is active against A. naeslundii, P. gingivalis, and P. anaerobius bacteria (MICs = 12.5, 6.2, and 3.1 μg/ml, respectively).{53621} Sclareol (5 and 10 μg/ml) inhibits LPS-induces increases in nitric oxide (NO) production and COX-2 and inducible nitric oxide synthase (iNOS) protein levels in RAW 264.7 macrophages.{53622} It reduces λ-carrageenan-induced hind paw edema in mice when administered at a dose of 10 mg/kg. It inhibits the growth of HCT116 cells (GI50 = 34 μM), as well as induces apoptosis and halts the cell cycle at the G1 phase in HCT116 cells when used at a concentration of 100 μM.{53623} Liposome-encapsulated sclareol (275 mg/kg, i.p.) reduces tumor growth in an HCT116 mouse xenograft model.
Brand:CaymanSKU:30287 - 1 gAvailable on backorder
Sclareol is a diterpene originally isolated from S. sclarea and has diverse biological activities.{53621,53622,53623} It is active against A. naeslundii, P. gingivalis, and P. anaerobius bacteria (MICs = 12.5, 6.2, and 3.1 μg/ml, respectively).{53621} Sclareol (5 and 10 μg/ml) inhibits LPS-induces increases in nitric oxide (NO) production and COX-2 and inducible nitric oxide synthase (iNOS) protein levels in RAW 264.7 macrophages.{53622} It reduces λ-carrageenan-induced hind paw edema in mice when administered at a dose of 10 mg/kg. It inhibits the growth of HCT116 cells (GI50 = 34 μM), as well as induces apoptosis and halts the cell cycle at the G1 phase in HCT116 cells when used at a concentration of 100 μM.{53623} Liposome-encapsulated sclareol (275 mg/kg, i.p.) reduces tumor growth in an HCT116 mouse xenograft model.
Brand:CaymanSKU:30287 - 10 gAvailable on backorder
Sclareol is a diterpene originally isolated from S. sclarea and has diverse biological activities.{53621,53622,53623} It is active against A. naeslundii, P. gingivalis, and P. anaerobius bacteria (MICs = 12.5, 6.2, and 3.1 μg/ml, respectively).{53621} Sclareol (5 and 10 μg/ml) inhibits LPS-induces increases in nitric oxide (NO) production and COX-2 and inducible nitric oxide synthase (iNOS) protein levels in RAW 264.7 macrophages.{53622} It reduces λ-carrageenan-induced hind paw edema in mice when administered at a dose of 10 mg/kg. It inhibits the growth of HCT116 cells (GI50 = 34 μM), as well as induces apoptosis and halts the cell cycle at the G1 phase in HCT116 cells when used at a concentration of 100 μM.{53623} Liposome-encapsulated sclareol (275 mg/kg, i.p.) reduces tumor growth in an HCT116 mouse xenograft model.
Brand:CaymanSKU:30287 - 5 gAvailable on backorder
Sclareol is a diterpene originally isolated from S. sclarea and has diverse biological activities.{53621,53622,53623} It is active against A. naeslundii, P. gingivalis, and P. anaerobius bacteria (MICs = 12.5, 6.2, and 3.1 μg/ml, respectively).{53621} Sclareol (5 and 10 μg/ml) inhibits LPS-induces increases in nitric oxide (NO) production and COX-2 and inducible nitric oxide synthase (iNOS) protein levels in RAW 264.7 macrophages.{53622} It reduces λ-carrageenan-induced hind paw edema in mice when administered at a dose of 10 mg/kg. It inhibits the growth of HCT116 cells (GI50 = 34 μM), as well as induces apoptosis and halts the cell cycle at the G1 phase in HCT116 cells when used at a concentration of 100 μM.{53623} Liposome-encapsulated sclareol (275 mg/kg, i.p.) reduces tumor growth in an HCT116 mouse xenograft model.
Brand:CaymanSKU:30287 - 500 mgAvailable on backorder
Sclareolide is a sesquiterpene lactone that has been found in Salvia and has diverse biological activities.{57254,57255,57257,57258} It inhibits mycelial growth in the phytopathogenic fungi B. cinerea, F. coeruleum, C. lunata, F. graminearum, and A. brassicae by 33.93, 67.14, 27.04, 46.22, and 32.48%, respectively, when used at a concentration of 100 μg/ml.{57255} Sclareolide is an Ebola virus entry inhibitor that reduces infection of HEK293T cells by an HIV-based virus system pseudotyped with Ebola virus glycoprotein (EC50 = 8 μM).{57257} It inhibits nitric oxide production in LPS-stimulated BV-2 cells (IC50 = 20.3 μM).{57258} Sclareolide (5, 10, and 20 μM) enhances gemcitabine-induced cell death in gemcitabine-resistant PANC-1 and AsPC-1 human pancreatic cancer cells.{57254}
Brand:CaymanSKU:31371 - 10 mgAvailable on backorder
Sclareolide is a sesquiterpene lactone that has been found in Salvia and has diverse biological activities.{57254,57255,57257,57258} It inhibits mycelial growth in the phytopathogenic fungi B. cinerea, F. coeruleum, C. lunata, F. graminearum, and A. brassicae by 33.93, 67.14, 27.04, 46.22, and 32.48%, respectively, when used at a concentration of 100 μg/ml.{57255} Sclareolide is an Ebola virus entry inhibitor that reduces infection of HEK293T cells by an HIV-based virus system pseudotyped with Ebola virus glycoprotein (EC50 = 8 μM).{57257} It inhibits nitric oxide production in LPS-stimulated BV-2 cells (IC50 = 20.3 μM).{57258} Sclareolide (5, 10, and 20 μM) enhances gemcitabine-induced cell death in gemcitabine-resistant PANC-1 and AsPC-1 human pancreatic cancer cells.{57254}
Brand:CaymanSKU:31371 - 100 mgAvailable on backorder
Sclareolide is a sesquiterpene lactone that has been found in Salvia and has diverse biological activities.{57254,57255,57257,57258} It inhibits mycelial growth in the phytopathogenic fungi B. cinerea, F. coeruleum, C. lunata, F. graminearum, and A. brassicae by 33.93, 67.14, 27.04, 46.22, and 32.48%, respectively, when used at a concentration of 100 μg/ml.{57255} Sclareolide is an Ebola virus entry inhibitor that reduces infection of HEK293T cells by an HIV-based virus system pseudotyped with Ebola virus glycoprotein (EC50 = 8 μM).{57257} It inhibits nitric oxide production in LPS-stimulated BV-2 cells (IC50 = 20.3 μM).{57258} Sclareolide (5, 10, and 20 μM) enhances gemcitabine-induced cell death in gemcitabine-resistant PANC-1 and AsPC-1 human pancreatic cancer cells.{57254}
Brand:CaymanSKU:31371 - 50 mgAvailable on backorder
Sclerotigenin is a natural diazepine originally isolated from P. sclerotigenum that acts as an insect growth regulator.{36573} It reduces the growth rate of first instar H. zea larvae by 42% relative to controls when administered in the standard test diet at 200 ppm.
Brand:CaymanSKU:23492 - 1 mgAvailable on backorder
Sclerotigenin is a natural diazepine originally isolated from P. sclerotigenum that acts as an insect growth regulator.{36573} It reduces the growth rate of first instar H. zea larvae by 42% relative to controls when administered in the standard test diet at 200 ppm.
Brand:CaymanSKU:23492 - 5 mgAvailable on backorder
Sclerotiorin is a natural product isolated primarily from Penicillium species. It inhibits soybean lipoxygenase-1 with an IC50 value of 4.2 µM.{15873} Sclerotiorin also exhibits a number of other activities including inhibition of cholesterol ester transfer protein (IC50 = 19.4 µM),{10419}, inhibition of Grb2-Shc interaction (IC50 = 22 µM),{16817}, and antagonism of endothelin receptors (IC50 = 114 and 152 µM for human ETA and ETB, respectively).{16816}
Brand:CaymanSKU:89460 - 1 mgAvailable on backorder
Sclerotiorin is a natural product isolated primarily from Penicillium species. It inhibits soybean lipoxygenase-1 with an IC50 value of 4.2 µM.{15873} Sclerotiorin also exhibits a number of other activities including inhibition of cholesterol ester transfer protein (IC50 = 19.4 µM),{10419}, inhibition of Grb2-Shc interaction (IC50 = 22 µM),{16817}, and antagonism of endothelin receptors (IC50 = 114 and 152 µM for human ETA and ETB, respectively).{16816}
Brand:CaymanSKU:89460 - 10 mgAvailable on backorder
Sclerotiorin is a natural product isolated primarily from Penicillium species. It inhibits soybean lipoxygenase-1 with an IC50 value of 4.2 µM.{15873} Sclerotiorin also exhibits a number of other activities including inhibition of cholesterol ester transfer protein (IC50 = 19.4 µM),{10419}, inhibition of Grb2-Shc interaction (IC50 = 22 µM),{16817}, and antagonism of endothelin receptors (IC50 = 114 and 152 µM for human ETA and ETB, respectively).{16816}
Brand:CaymanSKU:89460 - 5 mgAvailable on backorder
Sclerotiorin is a natural product isolated primarily from Penicillium species. It inhibits soybean lipoxygenase-1 with an IC50 value of 4.2 µM.{15873} Sclerotiorin also exhibits a number of other activities including inhibition of cholesterol ester transfer protein (IC50 = 19.4 µM),{10419}, inhibition of Grb2-Shc interaction (IC50 = 22 µM),{16817}, and antagonism of endothelin receptors (IC50 = 114 and 152 µM for human ETA and ETB, respectively).{16816}
Brand:CaymanSKU:89460 - 500 µgAvailable on backorder
Scoparone is a coumarin that has been found in A. capillaris and has diverse biological activities.{56223,56224,56226,56227,56225} It inhibits angiotensin II-induced extracellular matrix (ECM) remodeling and cell proliferation and reduces levels of collagen I and fibronectin in isolated primary neonatal rat cardiac fibroblasts when used at concentrations ranging from 1 to 10 µM.{56223} Scoparone suppresses PDGF-BB-induced rat aortic smooth muscle cell (RASMC) migration and wound healing in a scratch assay.{56224} In vivo, scoparone (3.5 mg/kg) reduces vascular neointima formation in a rat model of carotid artery balloon injury. Scoparone (80 mg/kg) reduces hepatocyte apoptosis, liver fibrosis, serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), and hepatic triglyceride levels in a mouse model of non-alcoholic steatohepatitis (NASH) induced by a methionine- and choline-deficient (MCD) diet.{56226} It reduces ulcer lesion area in a rat model of HCl- and ethanol-induced gastric ulcers.{56227} Scoparone also inhibits passive cutaneous anaphylaxis in rats.{56225}
Brand:CaymanSKU:20046 -Available on backorder
Scoparone is a coumarin that has been found in A. capillaris and has diverse biological activities.{56223,56224,56226,56227,56225} It inhibits angiotensin II-induced extracellular matrix (ECM) remodeling and cell proliferation and reduces levels of collagen I and fibronectin in isolated primary neonatal rat cardiac fibroblasts when used at concentrations ranging from 1 to 10 µM.{56223} Scoparone suppresses PDGF-BB-induced rat aortic smooth muscle cell (RASMC) migration and wound healing in a scratch assay.{56224} In vivo, scoparone (3.5 mg/kg) reduces vascular neointima formation in a rat model of carotid artery balloon injury. Scoparone (80 mg/kg) reduces hepatocyte apoptosis, liver fibrosis, serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), and hepatic triglyceride levels in a mouse model of non-alcoholic steatohepatitis (NASH) induced by a methionine- and choline-deficient (MCD) diet.{56226} It reduces ulcer lesion area in a rat model of HCl- and ethanol-induced gastric ulcers.{56227} Scoparone also inhibits passive cutaneous anaphylaxis in rats.{56225}
Brand:CaymanSKU:20046 -Available on backorder
Scoparone is a coumarin that has been found in A. capillaris and has diverse biological activities.{56223,56224,56226,56227,56225} It inhibits angiotensin II-induced extracellular matrix (ECM) remodeling and cell proliferation and reduces levels of collagen I and fibronectin in isolated primary neonatal rat cardiac fibroblasts when used at concentrations ranging from 1 to 10 µM.{56223} Scoparone suppresses PDGF-BB-induced rat aortic smooth muscle cell (RASMC) migration and wound healing in a scratch assay.{56224} In vivo, scoparone (3.5 mg/kg) reduces vascular neointima formation in a rat model of carotid artery balloon injury. Scoparone (80 mg/kg) reduces hepatocyte apoptosis, liver fibrosis, serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), and hepatic triglyceride levels in a mouse model of non-alcoholic steatohepatitis (NASH) induced by a methionine- and choline-deficient (MCD) diet.{56226} It reduces ulcer lesion area in a rat model of HCl- and ethanol-induced gastric ulcers.{56227} Scoparone also inhibits passive cutaneous anaphylaxis in rats.{56225}
Brand:CaymanSKU:20046 -Available on backorder
Scoparone is a coumarin that has been found in A. capillaris and has diverse biological activities.{56223,56224,56226,56227,56225} It inhibits angiotensin II-induced extracellular matrix (ECM) remodeling and cell proliferation and reduces levels of collagen I and fibronectin in isolated primary neonatal rat cardiac fibroblasts when used at concentrations ranging from 1 to 10 µM.{56223} Scoparone suppresses PDGF-BB-induced rat aortic smooth muscle cell (RASMC) migration and wound healing in a scratch assay.{56224} In vivo, scoparone (3.5 mg/kg) reduces vascular neointima formation in a rat model of carotid artery balloon injury. Scoparone (80 mg/kg) reduces hepatocyte apoptosis, liver fibrosis, serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), and hepatic triglyceride levels in a mouse model of non-alcoholic steatohepatitis (NASH) induced by a methionine- and choline-deficient (MCD) diet.{56226} It reduces ulcer lesion area in a rat model of HCl- and ethanol-induced gastric ulcers.{56227} Scoparone also inhibits passive cutaneous anaphylaxis in rats.{56225}
Brand:CaymanSKU:20046 -Available on backorder
Scopine is a metabolite of the muscarinic antagonist scopolamine.{43932} Scopine binds to muscarinic acetylcholine receptors with an IC50 value of 3 µM and is selective for muscarinic acetylcholine receptors over nicotinic acetylcholine receptors (IC50 = >500 µM).{43933} It reduces hyperphagia induced by the antipsychotics loxapine (Item No. 20760) and chlorpromazine (Item No. 16129) in C. elegans without affecting basal feeding.{43934} When conjugated to chlorambucil, scopine improves the blood-brain barrier permeability of chlorambucil (Item No. 23744).{43935}
Brand:CaymanSKU:27052 - 1 gAvailable on backorder
Scopine is a metabolite of the muscarinic antagonist scopolamine.{43932} Scopine binds to muscarinic acetylcholine receptors with an IC50 value of 3 µM and is selective for muscarinic acetylcholine receptors over nicotinic acetylcholine receptors (IC50 = >500 µM).{43933} It reduces hyperphagia induced by the antipsychotics loxapine (Item No. 20760) and chlorpromazine (Item No. 16129) in C. elegans without affecting basal feeding.{43934} When conjugated to chlorambucil, scopine improves the blood-brain barrier permeability of chlorambucil (Item No. 23744).{43935}
Brand:CaymanSKU:27052 - 250 mgAvailable on backorder
Scopine is a metabolite of the muscarinic antagonist scopolamine.{43932} Scopine binds to muscarinic acetylcholine receptors with an IC50 value of 3 µM and is selective for muscarinic acetylcholine receptors over nicotinic acetylcholine receptors (IC50 = >500 µM).{43933} It reduces hyperphagia induced by the antipsychotics loxapine (Item No. 20760) and chlorpromazine (Item No. 16129) in C. elegans without affecting basal feeding.{43934} When conjugated to chlorambucil, scopine improves the blood-brain barrier permeability of chlorambucil (Item No. 23744).{43935}
Brand:CaymanSKU:27052 - 500 mgAvailable on backorder
Scopolamine is a tropane alkaloid that can be found in many plants of the Solanaceae (nightshade) family.{22467} It is a muscarinic receptor antagonist that can be used to induce memory impairment in animals.{29782,30252,29442} Scopolamine prevents motion sickness, nausea, and vomiting in animals.{30252,22119}
Brand:CaymanSKU:- Scopolamine is a tropane alkaloid that can be found in many plants of the Solanaceae (nightshade) family.{22467} It is a muscarinic receptor antagonist that can be used to induce memory impairment in animals.{29782,30252,29442} Scopolamine prevents motion sickness, nausea, and vomiting in animals.{30252,22119}
Brand:CaymanSKU:-
Scopolamine N-butyl is an antispasmodic agent.{47496,47497} In vivo, scopolamine N-butyl inhibits electrically induced urinary bladder contractions in dogs (ED50s = 0.07-4.7 mg/kg).{47496} It also decreases the ileal phasic motility index (PMI) as well as colonic motility in canine models of ileal and colonic fistulas, respectively.{47497} Formulations containing scopolamine N-butyl have been used in the treatment of pain induced by abdominal cramps and bladder spasms.
Brand:CaymanSKU:27223 - 1 gAvailable on backorder
Scopolamine N-butyl is an antispasmodic agent.{47496,47497} In vivo, scopolamine N-butyl inhibits electrically induced urinary bladder contractions in dogs (ED50s = 0.07-4.7 mg/kg).{47496} It also decreases the ileal phasic motility index (PMI) as well as colonic motility in canine models of ileal and colonic fistulas, respectively.{47497} Formulations containing scopolamine N-butyl have been used in the treatment of pain induced by abdominal cramps and bladder spasms.
Brand:CaymanSKU:27223 - 10 gAvailable on backorder
Scopolamine N-butyl is an antispasmodic agent.{47496,47497} In vivo, scopolamine N-butyl inhibits electrically induced urinary bladder contractions in dogs (ED50s = 0.07-4.7 mg/kg).{47496} It also decreases the ileal phasic motility index (PMI) as well as colonic motility in canine models of ileal and colonic fistulas, respectively.{47497} Formulations containing scopolamine N-butyl have been used in the treatment of pain induced by abdominal cramps and bladder spasms.
Brand:CaymanSKU:27223 - 5 gAvailable on backorder
Scopoletin is a natural coumarin found in a variety of plants, including some species from the genus Scopolia. Like esculetin (Item No. 19286), scopoletin binds iron and is used by plants to acquire iron from alkaline soil.{31767} Scopoletin inhibits aldose reductase activity in galactose-fed rats, upregulates PPARγ expression, and triggers phosphorylation of Nrf2 in animals.{31986,31987,31988}
Brand:CaymanSKU:20042 -Available on backorder
Scopoletin is a natural coumarin found in a variety of plants, including some species from the genus Scopolia. Like esculetin (Item No. 19286), scopoletin binds iron and is used by plants to acquire iron from alkaline soil.{31767} Scopoletin inhibits aldose reductase activity in galactose-fed rats, upregulates PPARγ expression, and triggers phosphorylation of Nrf2 in animals.{31986,31987,31988}
Brand:CaymanSKU:20042 -Available on backorder
Scopoletin is a natural coumarin found in a variety of plants, including some species from the genus Scopolia. Like esculetin (Item No. 19286), scopoletin binds iron and is used by plants to acquire iron from alkaline soil.{31767} Scopoletin inhibits aldose reductase activity in galactose-fed rats, upregulates PPARγ expression, and triggers phosphorylation of Nrf2 in animals.{31986,31987,31988}
Brand:CaymanSKU:20042 -Available on backorder
DNA ligase IV seals double-strand breaks during the process of nonhomologous end-joining in DNA repair. Inhibiting this function in cancer cells is one strategy to prevent deleterious cell growth. SCR7 is a small molecule inhibitor of DNA ligase IV that prevents nonhomologous end-joining by interfering with ligase binding and activating apoptosis.{29468} It also inhibits ligase III, but does not affect the activity of T4 DNA ligase or ligase I. SCR7 has been used to increase the rate of homology directed repair triggered by DNA double-strand breaks and to inhibit cancer cell growth in vitro (IC50s = 8-120 µM) and in mouse models when co-administered with double-strand break-inducing therapeutic compounds.{29468,29465,29466,29467}
Brand:CaymanSKU:-Available on backorder
DNA ligase IV seals double-strand breaks during the process of nonhomologous end-joining in DNA repair. Inhibiting this function in cancer cells is one strategy to prevent deleterious cell growth. SCR7 is a small molecule inhibitor of DNA ligase IV that prevents nonhomologous end-joining by interfering with ligase binding and activating apoptosis.{29468} It also inhibits ligase III, but does not affect the activity of T4 DNA ligase or ligase I. SCR7 has been used to increase the rate of homology directed repair triggered by DNA double-strand breaks and to inhibit cancer cell growth in vitro (IC50s = 8-120 µM) and in mouse models when co-administered with double-strand break-inducing therapeutic compounds.{29468,29465,29466,29467}
Brand:CaymanSKU:-Available on backorder
DNA ligase IV seals double-strand breaks during the process of nonhomologous end-joining in DNA repair. Inhibiting this function in cancer cells is one strategy to prevent deleterious cell growth. SCR7 is a small molecule inhibitor of DNA ligase IV that prevents nonhomologous end-joining by interfering with ligase binding and activating apoptosis.{29468} It also inhibits ligase III, but does not affect the activity of T4 DNA ligase or ligase I. SCR7 has been used to increase the rate of homology directed repair triggered by DNA double-strand breaks and to inhibit cancer cell growth in vitro (IC50s = 8-120 µM) and in mouse models when co-administered with double-strand break-inducing therapeutic compounds.{29468,29465,29466,29467}
Brand:CaymanSKU:-Available on backorder
DNA ligase IV seals double-strand breaks during the process of nonhomologous end-joining in DNA repair. Inhibiting this function in cancer cells is one strategy to prevent deleterious cell growth. SCR7 is a small molecule inhibitor of DNA ligase IV that prevents nonhomologous end-joining by interfering with ligase binding and activating apoptosis.{29468} It also inhibits ligase III, but does not affect the activity of T4 DNA ligase or ligase I. SCR7 has been used to increase the rate of homology directed repair triggered by DNA double-strand breaks and to inhibit cancer cell growth in vitro (IC50s = 8-120 µM) and in mouse models when co-administered with double-strand break-inducing therapeutic compounds.{29468,29465,29466,29467}
Brand:CaymanSKU:-Available on backorder
Scriptaid is a histone deacetylase inhibitor that has an optimal concentration of 6-8 μM in a cell-based assay, is less toxic than trichostatin A, and works in a wide variety of biological systems.{18409} It induces cell cycle arrest in colon cancer cells in culture and inhibits tumor growth in vitro and in vivo.{18447,18440} Scriptaid also facilitates the cloning of inbred mouse strains produced by somatic cell nuclear transfer.{18445}
Brand:CaymanSKU:10572 - 1 mgAvailable on backorder
Scriptaid is a histone deacetylase inhibitor that has an optimal concentration of 6-8 μM in a cell-based assay, is less toxic than trichostatin A, and works in a wide variety of biological systems.{18409} It induces cell cycle arrest in colon cancer cells in culture and inhibits tumor growth in vitro and in vivo.{18447,18440} Scriptaid also facilitates the cloning of inbred mouse strains produced by somatic cell nuclear transfer.{18445}
Brand:CaymanSKU:10572 - 10 mgAvailable on backorder
Scriptaid is a histone deacetylase inhibitor that has an optimal concentration of 6-8 μM in a cell-based assay, is less toxic than trichostatin A, and works in a wide variety of biological systems.{18409} It induces cell cycle arrest in colon cancer cells in culture and inhibits tumor growth in vitro and in vivo.{18447,18440} Scriptaid also facilitates the cloning of inbred mouse strains produced by somatic cell nuclear transfer.{18445}
Brand:CaymanSKU:10572 - 5 mgAvailable on backorder
Scutellarein is a flavone that has been isolated from S. baicalensis and has antioxidant, enzyme inhibitory, anti-inflammatory, and antiproliferative biological activities.{37603,37604,37605,37606,37607,37608} It has antioxidant activity in a total reactive antioxidant potential (TRAP) assay when used at a concentration of 1 μg/ml.{37604} Scutellarein inhibits sucrose hydrolysis by rat intestinal α-glucosidase and ATPase activity of the severe acute respiratory syndrome (SARS) coronavirus helicase nsP13 (IC50s = 12 and 0.86 μM, respectively).{37605,37606} It decreases nitric oxide (NO) release and mRNA expression of inducible NO synthase (iNOS) and TNF-α induced by LPS in RAW 264.7 macrophages when used at a concentration of 50 μM.{37607} In vivo, scutellarein (0.5 μg/g) decreases tumor weight and volume in an HT-1080 human fibrosarcoma mouse xenograft model.{37608}
Brand:CaymanSKU:24977 - 1 mgAvailable on backorder
Scutellarein is a flavone that has been isolated from S. baicalensis and has antioxidant, enzyme inhibitory, anti-inflammatory, and antiproliferative biological activities.{37603,37604,37605,37606,37607,37608} It has antioxidant activity in a total reactive antioxidant potential (TRAP) assay when used at a concentration of 1 μg/ml.{37604} Scutellarein inhibits sucrose hydrolysis by rat intestinal α-glucosidase and ATPase activity of the severe acute respiratory syndrome (SARS) coronavirus helicase nsP13 (IC50s = 12 and 0.86 μM, respectively).{37605,37606} It decreases nitric oxide (NO) release and mRNA expression of inducible NO synthase (iNOS) and TNF-α induced by LPS in RAW 264.7 macrophages when used at a concentration of 50 μM.{37607} In vivo, scutellarein (0.5 μg/g) decreases tumor weight and volume in an HT-1080 human fibrosarcoma mouse xenograft model.{37608}
Brand:CaymanSKU:24977 - 10 mgAvailable on backorder
Scutellarein is a flavone that has been isolated from S. baicalensis and has antioxidant, enzyme inhibitory, anti-inflammatory, and antiproliferative biological activities.{37603,37604,37605,37606,37607,37608} It has antioxidant activity in a total reactive antioxidant potential (TRAP) assay when used at a concentration of 1 μg/ml.{37604} Scutellarein inhibits sucrose hydrolysis by rat intestinal α-glucosidase and ATPase activity of the severe acute respiratory syndrome (SARS) coronavirus helicase nsP13 (IC50s = 12 and 0.86 μM, respectively).{37605,37606} It decreases nitric oxide (NO) release and mRNA expression of inducible NO synthase (iNOS) and TNF-α induced by LPS in RAW 264.7 macrophages when used at a concentration of 50 μM.{37607} In vivo, scutellarein (0.5 μg/g) decreases tumor weight and volume in an HT-1080 human fibrosarcoma mouse xenograft model.{37608}
Brand:CaymanSKU:24977 - 5 mgAvailable on backorder
Scutellarein is a flavone that has been isolated from S. baicalensis and has antioxidant, enzyme inhibitory, anti-inflammatory, and antiproliferative biological activities.{37603,37604,37605,37606,37607,37608} It has antioxidant activity in a total reactive antioxidant potential (TRAP) assay when used at a concentration of 1 μg/ml.{37604} Scutellarein inhibits sucrose hydrolysis by rat intestinal α-glucosidase and ATPase activity of the severe acute respiratory syndrome (SARS) coronavirus helicase nsP13 (IC50s = 12 and 0.86 μM, respectively).{37605,37606} It decreases nitric oxide (NO) release and mRNA expression of inducible NO synthase (iNOS) and TNF-α induced by LPS in RAW 264.7 macrophages when used at a concentration of 50 μM.{37607} In vivo, scutellarein (0.5 μg/g) decreases tumor weight and volume in an HT-1080 human fibrosarcoma mouse xenograft model.{37608}
Brand:CaymanSKU:24977 - 50 mgAvailable on backorder
Scutellarin is a flavone that has been found in S. barbata and has diverse biological activities, including anticancer, lipid lowering, antioxidative, and neurocognitive properties.{43989,43990,43991} It inhibits proliferation of PC-9 and H1975 non-small cell lung cancer (NSCLC) cells in a concentration-dependent manner and induces apoptosis and autophagy when used at a concentration of 160 µM, effects that can be blocked by the autophagy inhibitor HCQ (Item No. 17911).{43989} Scutellarin (30 and 60 mg/kg per day) reduces tumor growth in an H1975 mouse xenograft model. It decreases serum total cholesterol and LDL-cholesterol and increases HDL-cholesterol in a high-fat diet-induced mouse model of non-alcoholic fatty liver disease (NAFLD) when administered at doses of 25 and 50 mg/kg.{43990} It decreases hepatic malondialdehyde (MDA), glutamic-oxalacetic transaminase (GOT), and glutamic-pyruvic transaminase (GPT) activity, increases catalase (CAT) and total antioxidative capacity (T-AOC) activity, and increases the hepatic expression of PPARγ, PGC-1α, and Nrf2 in the same model. Scutellarin (5, 25, and 50 mg/kg per day) also prevents deficits in spatial and novel object memory in rats in the Y maze and novel object recognition test, respectively.{43991}
Brand:CaymanSKU:27461 - 10 mgAvailable on backorder
Scutellarin is a flavone that has been found in S. barbata and has diverse biological activities, including anticancer, lipid lowering, antioxidative, and neurocognitive properties.{43989,43990,43991} It inhibits proliferation of PC-9 and H1975 non-small cell lung cancer (NSCLC) cells in a concentration-dependent manner and induces apoptosis and autophagy when used at a concentration of 160 µM, effects that can be blocked by the autophagy inhibitor HCQ (Item No. 17911).{43989} Scutellarin (30 and 60 mg/kg per day) reduces tumor growth in an H1975 mouse xenograft model. It decreases serum total cholesterol and LDL-cholesterol and increases HDL-cholesterol in a high-fat diet-induced mouse model of non-alcoholic fatty liver disease (NAFLD) when administered at doses of 25 and 50 mg/kg.{43990} It decreases hepatic malondialdehyde (MDA), glutamic-oxalacetic transaminase (GOT), and glutamic-pyruvic transaminase (GPT) activity, increases catalase (CAT) and total antioxidative capacity (T-AOC) activity, and increases the hepatic expression of PPARγ, PGC-1α, and Nrf2 in the same model. Scutellarin (5, 25, and 50 mg/kg per day) also prevents deficits in spatial and novel object memory in rats in the Y maze and novel object recognition test, respectively.{43991}
Brand:CaymanSKU:27461 - 100 mgAvailable on backorder
Scutellarin is a flavone that has been found in S. barbata and has diverse biological activities, including anticancer, lipid lowering, antioxidative, and neurocognitive properties.{43989,43990,43991} It inhibits proliferation of PC-9 and H1975 non-small cell lung cancer (NSCLC) cells in a concentration-dependent manner and induces apoptosis and autophagy when used at a concentration of 160 µM, effects that can be blocked by the autophagy inhibitor HCQ (Item No. 17911).{43989} Scutellarin (30 and 60 mg/kg per day) reduces tumor growth in an H1975 mouse xenograft model. It decreases serum total cholesterol and LDL-cholesterol and increases HDL-cholesterol in a high-fat diet-induced mouse model of non-alcoholic fatty liver disease (NAFLD) when administered at doses of 25 and 50 mg/kg.{43990} It decreases hepatic malondialdehyde (MDA), glutamic-oxalacetic transaminase (GOT), and glutamic-pyruvic transaminase (GPT) activity, increases catalase (CAT) and total antioxidative capacity (T-AOC) activity, and increases the hepatic expression of PPARγ, PGC-1α, and Nrf2 in the same model. Scutellarin (5, 25, and 50 mg/kg per day) also prevents deficits in spatial and novel object memory in rats in the Y maze and novel object recognition test, respectively.{43991}
Brand:CaymanSKU:27461 - 25 mgAvailable on backorder
Scutellarin is a flavone that has been found in S. barbata and has diverse biological activities, including anticancer, lipid lowering, antioxidative, and neurocognitive properties.{43989,43990,43991} It inhibits proliferation of PC-9 and H1975 non-small cell lung cancer (NSCLC) cells in a concentration-dependent manner and induces apoptosis and autophagy when used at a concentration of 160 µM, effects that can be blocked by the autophagy inhibitor HCQ (Item No. 17911).{43989} Scutellarin (30 and 60 mg/kg per day) reduces tumor growth in an H1975 mouse xenograft model. It decreases serum total cholesterol and LDL-cholesterol and increases HDL-cholesterol in a high-fat diet-induced mouse model of non-alcoholic fatty liver disease (NAFLD) when administered at doses of 25 and 50 mg/kg.{43990} It decreases hepatic malondialdehyde (MDA), glutamic-oxalacetic transaminase (GOT), and glutamic-pyruvic transaminase (GPT) activity, increases catalase (CAT) and total antioxidative capacity (T-AOC) activity, and increases the hepatic expression of PPARγ, PGC-1α, and Nrf2 in the same model. Scutellarin (5, 25, and 50 mg/kg per day) also prevents deficits in spatial and novel object memory in rats in the Y maze and novel object recognition test, respectively.{43991}
Brand:CaymanSKU:27461 - 50 mgAvailable on backorder
scyllo-Inositol is a stereoisomer of inositol. It induces a structural transition in amyloid-β (1-42) (Aβ42), but not Aβ40, from a random coil to β-sheet structure but prevents Aβ42 fibril formation in cell-free assays.{52735} scyllo-Inositol reduces Aβ40- and Aβ42-induced decreases in the survival of PC12 cells. It reduces increases in soluble and insoluble brain Aβ40 and Aβ42 levels in four- and six-month-old mice in the TgCRND8 model of Alzheimer’s disease when administered starting at six weeks of age, which is prior to the onset of increased Aβ levels and spatial learning deficits.{52736} It also reduces increases in insoluble brain Aβ40 and Aβ42 levels in six-month-old mice when administered starting at five months of age when the neuropathological and learning deficits are already established. scyllo-Inositol improves established spatial learning and memory deficits in the Morris water maze when compared with TgCRND8 control and non-transgenic littermate control mice. It also improves survival of TgCRND8 mice.
Brand:CaymanSKU:31214 - 10 mgAvailable on backorder
scyllo-Inositol is a stereoisomer of inositol. It induces a structural transition in amyloid-β (1-42) (Aβ42), but not Aβ40, from a random coil to β-sheet structure but prevents Aβ42 fibril formation in cell-free assays.{52735} scyllo-Inositol reduces Aβ40- and Aβ42-induced decreases in the survival of PC12 cells. It reduces increases in soluble and insoluble brain Aβ40 and Aβ42 levels in four- and six-month-old mice in the TgCRND8 model of Alzheimer’s disease when administered starting at six weeks of age, which is prior to the onset of increased Aβ levels and spatial learning deficits.{52736} It also reduces increases in insoluble brain Aβ40 and Aβ42 levels in six-month-old mice when administered starting at five months of age when the neuropathological and learning deficits are already established. scyllo-Inositol improves established spatial learning and memory deficits in the Morris water maze when compared with TgCRND8 control and non-transgenic littermate control mice. It also improves survival of TgCRND8 mice.
Brand:CaymanSKU:31214 - 100 mgAvailable on backorder
scyllo-Inositol is a stereoisomer of inositol. It induces a structural transition in amyloid-β (1-42) (Aβ42), but not Aβ40, from a random coil to β-sheet structure but prevents Aβ42 fibril formation in cell-free assays.{52735} scyllo-Inositol reduces Aβ40- and Aβ42-induced decreases in the survival of PC12 cells. It reduces increases in soluble and insoluble brain Aβ40 and Aβ42 levels in four- and six-month-old mice in the TgCRND8 model of Alzheimer’s disease when administered starting at six weeks of age, which is prior to the onset of increased Aβ levels and spatial learning deficits.{52736} It also reduces increases in insoluble brain Aβ40 and Aβ42 levels in six-month-old mice when administered starting at five months of age when the neuropathological and learning deficits are already established. scyllo-Inositol improves established spatial learning and memory deficits in the Morris water maze when compared with TgCRND8 control and non-transgenic littermate control mice. It also improves survival of TgCRND8 mice.
Brand:CaymanSKU:31214 - 5 mgAvailable on backorder
scyllo-Inositol is a stereoisomer of inositol. It induces a structural transition in amyloid-β (1-42) (Aβ42), but not Aβ40, from a random coil to β-sheet structure but prevents Aβ42 fibril formation in cell-free assays.{52735} scyllo-Inositol reduces Aβ40- and Aβ42-induced decreases in the survival of PC12 cells. It reduces increases in soluble and insoluble brain Aβ40 and Aβ42 levels in four- and six-month-old mice in the TgCRND8 model of Alzheimer’s disease when administered starting at six weeks of age, which is prior to the onset of increased Aβ levels and spatial learning deficits.{52736} It also reduces increases in insoluble brain Aβ40 and Aβ42 levels in six-month-old mice when administered starting at five months of age when the neuropathological and learning deficits are already established. scyllo-Inositol improves established spatial learning and memory deficits in the Morris water maze when compared with TgCRND8 control and non-transgenic littermate control mice. It also improves survival of TgCRND8 mice.
Brand:CaymanSKU:31214 - 50 mgAvailable on backorder
SD 169 is a selective ATP competitive inhibitor of the MAP kinases p38α (IC50 = 3.2 nM) and p38β (IC50 = 122 nM).{22220} It has no inhibitory effect against a panel of other kinases, including p38γ MAP kinase, ERK2, JNK-1, and MAPKAPK-2, when tested in vitro at 50 μM.{22220} SD 169 is orally active, significantly reducing p38 MAP kinase expression in T cells of nonobese diabetic mice when delivered in chow at 600 mg/kg.{22220} In this model, SD 169 also reduced the incidence of diabetes, lowered blood glucose, and improved glucose homeostasis.{22220} SD 169 also enhances axonal regeneration after sciatic nerve crush injury in rats, when given by gavage (30 mg/kg) before and after nerve damage.{22221}
Brand:CaymanSKU:- SD 169 is a selective ATP competitive inhibitor of the MAP kinases p38α (IC50 = 3.2 nM) and p38β (IC50 = 122 nM).{22220} It has no inhibitory effect against a panel of other kinases, including p38γ MAP kinase, ERK2, JNK-1, and MAPKAPK-2, when tested in vitro at 50 μM.{22220} SD 169 is orally active, significantly reducing p38 MAP kinase expression in T cells of nonobese diabetic mice when delivered in chow at 600 mg/kg.{22220} In this model, SD 169 also reduced the incidence of diabetes, lowered blood glucose, and improved glucose homeostasis.{22220} SD 169 also enhances axonal regeneration after sciatic nerve crush injury in rats, when given by gavage (30 mg/kg) before and after nerve damage.{22221}
Brand:CaymanSKU:- SD 169 is a selective ATP competitive inhibitor of the MAP kinases p38α (IC50 = 3.2 nM) and p38β (IC50 = 122 nM).{22220} It has no inhibitory effect against a panel of other kinases, including p38γ MAP kinase, ERK2, JNK-1, and MAPKAPK-2, when tested in vitro at 50 μM.{22220} SD 169 is orally active, significantly reducing p38 MAP kinase expression in T cells of nonobese diabetic mice when delivered in chow at 600 mg/kg.{22220} In this model, SD 169 also reduced the incidence of diabetes, lowered blood glucose, and improved glucose homeostasis.{22220} SD 169 also enhances axonal regeneration after sciatic nerve crush injury in rats, when given by gavage (30 mg/kg) before and after nerve damage.{22221}
Brand:CaymanSKU:-
TGF-β is a cell growth and differentiation factor that has roles in cancer, fibrosis, and numerous other pathologies.{20609,17350} TGF-β signals through two receptor tyrosine kinases, TGF-βRI and TGF-βRII. SD 208 is a potent inhibitor of TGF-βRI kinase (EC50 = 48 nM) that has minimal or no effect at a variety of other tyrosine or serine/threonine kinases, including TGF-βRII kinase.{27141} It blocks both autocrine and paracrine TGF-β signaling in glioma cells, inhibiting TGF-β-induced migration and invasion without affecting viability or proliferation.{27141} SD 208 is orally bioavailable and prevents TGF-β-induced Smad phosphorylation in spleens and brains of mice.{27141} It improves survival in mice with xenografted glioma by heightening the immune response against tumor cells and reverses bronchial hyperresponsiveness to allergens in ovalbumin-exposed mice.{27141,27142} SD 208 also suppresses TGF-β-induced differentiation of proliferating myofibroblasts and induces dedifferentiation in the absence of TGF-β.{27144,27143}
Brand:CaymanSKU:-Out of stock
TGF-β is a cell growth and differentiation factor that has roles in cancer, fibrosis, and numerous other pathologies.{20609,17350} TGF-β signals through two receptor tyrosine kinases, TGF-βRI and TGF-βRII. SD 208 is a potent inhibitor of TGF-βRI kinase (EC50 = 48 nM) that has minimal or no effect at a variety of other tyrosine or serine/threonine kinases, including TGF-βRII kinase.{27141} It blocks both autocrine and paracrine TGF-β signaling in glioma cells, inhibiting TGF-β-induced migration and invasion without affecting viability or proliferation.{27141} SD 208 is orally bioavailable and prevents TGF-β-induced Smad phosphorylation in spleens and brains of mice.{27141} It improves survival in mice with xenografted glioma by heightening the immune response against tumor cells and reverses bronchial hyperresponsiveness to allergens in ovalbumin-exposed mice.{27141,27142} SD 208 also suppresses TGF-β-induced differentiation of proliferating myofibroblasts and induces dedifferentiation in the absence of TGF-β.{27144,27143}
Brand:CaymanSKU:-Out of stock
TGF-β is a cell growth and differentiation factor that has roles in cancer, fibrosis, and numerous other pathologies.{20609,17350} TGF-β signals through two receptor tyrosine kinases, TGF-βRI and TGF-βRII. SD 208 is a potent inhibitor of TGF-βRI kinase (EC50 = 48 nM) that has minimal or no effect at a variety of other tyrosine or serine/threonine kinases, including TGF-βRII kinase.{27141} It blocks both autocrine and paracrine TGF-β signaling in glioma cells, inhibiting TGF-β-induced migration and invasion without affecting viability or proliferation.{27141} SD 208 is orally bioavailable and prevents TGF-β-induced Smad phosphorylation in spleens and brains of mice.{27141} It improves survival in mice with xenografted glioma by heightening the immune response against tumor cells and reverses bronchial hyperresponsiveness to allergens in ovalbumin-exposed mice.{27141,27142} SD 208 also suppresses TGF-β-induced differentiation of proliferating myofibroblasts and induces dedifferentiation in the absence of TGF-β.{27144,27143}
Brand:CaymanSKU:-Out of stock
TGF-β is a cell growth and differentiation factor that has roles in cancer, fibrosis, and numerous other pathologies.{20609,17350} TGF-β signals through two receptor tyrosine kinases, TGF-βRI and TGF-βRII. SD 208 is a potent inhibitor of TGF-βRI kinase (EC50 = 48 nM) that has minimal or no effect at a variety of other tyrosine or serine/threonine kinases, including TGF-βRII kinase.{27141} It blocks both autocrine and paracrine TGF-β signaling in glioma cells, inhibiting TGF-β-induced migration and invasion without affecting viability or proliferation.{27141} SD 208 is orally bioavailable and prevents TGF-β-induced Smad phosphorylation in spleens and brains of mice.{27141} It improves survival in mice with xenografted glioma by heightening the immune response against tumor cells and reverses bronchial hyperresponsiveness to allergens in ovalbumin-exposed mice.{27141,27142} SD 208 also suppresses TGF-β-induced differentiation of proliferating myofibroblasts and induces dedifferentiation in the absence of TGF-β.{27144,27143}
Brand:CaymanSKU:-Out of stock
SD 2590 is an inhibitor of matrix metalloproteinase-2 (MMP-2), -3, -8, -9, and -13 (IC50s = 50s = >10,000 and 7,000 nM, respectively). SD 2590 (10 mg/kg per day) inhibits dilation of the left ventricle in rats following myocardial infarction (MI) compared to MI vehicle control animals.
Brand:CaymanSKU:27680 - 1 mgAvailable on backorder
SD 2590 is an inhibitor of matrix metalloproteinase-2 (MMP-2), -3, -8, -9, and -13 (IC50s = 50s = >10,000 and 7,000 nM, respectively). SD 2590 (10 mg/kg per day) inhibits dilation of the left ventricle in rats following myocardial infarction (MI) compared to MI vehicle control animals.
Brand:CaymanSKU:27680 - 5 mgAvailable on backorder
SD-06 is an ATP-competitive inhibitor of p38α MAPK (IC50 = 0.016 µM).{54326} It is selective for p38α over p38β, p38γ, and p38δ MAPKs (IC50s = 0.677, >100, and >100 µM, respectively), as well as a panel of 54 additional kinases (IC50s = >3 µM for all). SD-06 inhibits LPS-induced TNF-α, IL-6, and IL-1β release from primary human monocytes (IC50s = 79.4, 106.9, and 105.9 nM, respectively). It decreases IL-1β-induced production of prostaglandin E2 (PGE2; Item No. 14010) in patient-derived rheumatoid arthritis synovial fibroblasts (RASFs; IC50 = 96.2 nM). SD-06 (30 mg/kg) reduces carrageenan-induced paw swelling and hyperalgesia in rats. It also reduces the incidence of arthritis in a mouse model of collagen-induced arthritis and protects against joint and bone destruction in a rat model of streptococcal cell wall-induced arthritis.
Brand:CaymanSKU:30686 - 10 mgAvailable on backorder
SD-06 is an ATP-competitive inhibitor of p38α MAPK (IC50 = 0.016 µM).{54326} It is selective for p38α over p38β, p38γ, and p38δ MAPKs (IC50s = 0.677, >100, and >100 µM, respectively), as well as a panel of 54 additional kinases (IC50s = >3 µM for all). SD-06 inhibits LPS-induced TNF-α, IL-6, and IL-1β release from primary human monocytes (IC50s = 79.4, 106.9, and 105.9 nM, respectively). It decreases IL-1β-induced production of prostaglandin E2 (PGE2; Item No. 14010) in patient-derived rheumatoid arthritis synovial fibroblasts (RASFs; IC50 = 96.2 nM). SD-06 (30 mg/kg) reduces carrageenan-induced paw swelling and hyperalgesia in rats. It also reduces the incidence of arthritis in a mouse model of collagen-induced arthritis and protects against joint and bone destruction in a rat model of streptococcal cell wall-induced arthritis.
Brand:CaymanSKU:30686 - 25 mgAvailable on backorder
SD-06 is an ATP-competitive inhibitor of p38α MAPK (IC50 = 0.016 µM).{54326} It is selective for p38α over p38β, p38γ, and p38δ MAPKs (IC50s = 0.677, >100, and >100 µM, respectively), as well as a panel of 54 additional kinases (IC50s = >3 µM for all). SD-06 inhibits LPS-induced TNF-α, IL-6, and IL-1β release from primary human monocytes (IC50s = 79.4, 106.9, and 105.9 nM, respectively). It decreases IL-1β-induced production of prostaglandin E2 (PGE2; Item No. 14010) in patient-derived rheumatoid arthritis synovial fibroblasts (RASFs; IC50 = 96.2 nM). SD-06 (30 mg/kg) reduces carrageenan-induced paw swelling and hyperalgesia in rats. It also reduces the incidence of arthritis in a mouse model of collagen-induced arthritis and protects against joint and bone destruction in a rat model of streptococcal cell wall-induced arthritis.
Brand:CaymanSKU:30686 - 5 mgAvailable on backorder
SD-06 is an ATP-competitive inhibitor of p38α MAPK (IC50 = 0.016 µM).{54326} It is selective for p38α over p38β, p38γ, and p38δ MAPKs (IC50s = 0.677, >100, and >100 µM, respectively), as well as a panel of 54 additional kinases (IC50s = >3 µM for all). SD-06 inhibits LPS-induced TNF-α, IL-6, and IL-1β release from primary human monocytes (IC50s = 79.4, 106.9, and 105.9 nM, respectively). It decreases IL-1β-induced production of prostaglandin E2 (PGE2; Item No. 14010) in patient-derived rheumatoid arthritis synovial fibroblasts (RASFs; IC50 = 96.2 nM). SD-06 (30 mg/kg) reduces carrageenan-induced paw swelling and hyperalgesia in rats. It also reduces the incidence of arthritis in a mouse model of collagen-induced arthritis and protects against joint and bone destruction in a rat model of streptococcal cell wall-induced arthritis.
Brand:CaymanSKU:30686 - 50 mgAvailable on backorder
SD-1029 is a Janus kinase 2 (JAK2) inhibitor.{48790,48791} It inhibits autophosphorylation of recombinant JAK2 when used at concentrations of 30 and 100 μM and decreases levels of phosphorylated JAK2, but not JAK1 or Src, in MDA-MB-468 and paclitaxel-resistant OVCAR8TR cells when used at a concentration of 10 μM.{48790} SD-1029 (10 μM) decreases levels of phosphorylated STAT3 in MDA-MB-468, MDA-BM-435, OVCAR8TR, and SKOV3TR cells and inhibits IL-6-induced nuclear translocation of STAT3 in BHK-21 and U2OS cells.{48790} It decreases the viability of and increases levels of cleaved caspase-3 in SNU-387, SNU-398, HepG2, and Huh7 hepatocellular carcinoma cells when used at a concentration of 10 μM.{48792} SD-1029 (100 and 1,000 nM) inhibits hepatitis A virus replication in GL37 cells.{48791}
Brand:CaymanSKU:21029 -Out of stock
SD-1029 is a Janus kinase 2 (JAK2) inhibitor.{48790,48791} It inhibits autophosphorylation of recombinant JAK2 when used at concentrations of 30 and 100 μM and decreases levels of phosphorylated JAK2, but not JAK1 or Src, in MDA-MB-468 and paclitaxel-resistant OVCAR8TR cells when used at a concentration of 10 μM.{48790} SD-1029 (10 μM) decreases levels of phosphorylated STAT3 in MDA-MB-468, MDA-BM-435, OVCAR8TR, and SKOV3TR cells and inhibits IL-6-induced nuclear translocation of STAT3 in BHK-21 and U2OS cells.{48790} It decreases the viability of and increases levels of cleaved caspase-3 in SNU-387, SNU-398, HepG2, and Huh7 hepatocellular carcinoma cells when used at a concentration of 10 μM.{48792} SD-1029 (100 and 1,000 nM) inhibits hepatitis A virus replication in GL37 cells.{48791}
Brand:CaymanSKU:21029 -Out of stock
SDB-006 is a cannabimimetic indole that binds the cannabinoid central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors with EC50 values of 19 and 134 nM, respectively.{24972} It was discovered during research of the related compound JWH 018 adamantyl carboxamide (Item No. 9001193), which has been sold illicitly in herbal blends.{24972} This product is intended for research and forensic applications.
Brand:CaymanSKU:- SDB-006 is a cannabimimetic indole that binds the cannabinoid central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors with EC50 values of 19 and 134 nM, respectively.{24972} It was discovered during research of the related compound JWH 018 adamantyl carboxamide (Item No. 9001193), which has been sold illicitly in herbal blends.{24972} This product is intended for research and forensic applications.
Brand:CaymanSKU:- SDB-006 is a cannabimimetic indole that binds the cannabinoid central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors with EC50 values of 19 and 134 nM, respectively.{24972} It was discovered during research of the related compound JWH 018 adamantyl carboxamide (Item No. 9001193), which has been sold illicitly in herbal blends.{24972} This product is intended for research and forensic applications.
Brand:CaymanSKU:-
SDB-006 N-phenyl analog is a cannabimimetic indole that binds the central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors with EC50 values of 21 and 140 nM, respectively.{24972} It was discovered during research of the related compound JWH 018 adamantyl carboxamide (Item No. 9001193), which has been sold illicitly in herbal blends.{24972} This product is intended for research and forensic applications.
Brand:CaymanSKU:- SDB-006 N-phenyl analog is a cannabimimetic indole that binds the central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors with EC50 values of 21 and 140 nM, respectively.{24972} It was discovered during research of the related compound JWH 018 adamantyl carboxamide (Item No. 9001193), which has been sold illicitly in herbal blends.{24972} This product is intended for research and forensic applications.
Brand:CaymanSKU:- SDB-006 N-phenyl analog is a cannabimimetic indole that binds the central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors with EC50 values of 21 and 140 nM, respectively.{24972} It was discovered during research of the related compound JWH 018 adamantyl carboxamide (Item No. 9001193), which has been sold illicitly in herbal blends.{24972} This product is intended for research and forensic applications.
Brand:CaymanSKU:-
SE 175 is an organic nitrate compound of the same general class as nitroglycerin. These nitrate compounds can act as NO-donors in vivo following reductive transformation of the nitrate group to nitric oxide. The nitroxyacylated thiosalicylates, such as SE 175, were developed in an effort to facilitate this reductive process and accelerate the release of NO. SE 175 is stable in buffer or saline solution. In the intact rat, it stimulates endothelial soluble guanylate cyclase and induces aortic vasorelaxation with an EC50 of 20 µM, which is intermediate in potency between nitroglycerine and isosorbide dinitrate.{8459}
Brand:CaymanSKU:82340 - 10 mgAvailable on backorder
SE 175 is an organic nitrate compound of the same general class as nitroglycerin. These nitrate compounds can act as NO-donors in vivo following reductive transformation of the nitrate group to nitric oxide. The nitroxyacylated thiosalicylates, such as SE 175, were developed in an effort to facilitate this reductive process and accelerate the release of NO. SE 175 is stable in buffer or saline solution. In the intact rat, it stimulates endothelial soluble guanylate cyclase and induces aortic vasorelaxation with an EC50 of 20 µM, which is intermediate in potency between nitroglycerine and isosorbide dinitrate.{8459}
Brand:CaymanSKU:82340 - 100 mgAvailable on backorder
SE 175 is an organic nitrate compound of the same general class as nitroglycerin. These nitrate compounds can act as NO-donors in vivo following reductive transformation of the nitrate group to nitric oxide. The nitroxyacylated thiosalicylates, such as SE 175, were developed in an effort to facilitate this reductive process and accelerate the release of NO. SE 175 is stable in buffer or saline solution. In the intact rat, it stimulates endothelial soluble guanylate cyclase and induces aortic vasorelaxation with an EC50 of 20 µM, which is intermediate in potency between nitroglycerine and isosorbide dinitrate.{8459}
Brand:CaymanSKU:82340 - 5 mgAvailable on backorder
SE 175 is an organic nitrate compound of the same general class as nitroglycerin. These nitrate compounds can act as NO-donors in vivo following reductive transformation of the nitrate group to nitric oxide. The nitroxyacylated thiosalicylates, such as SE 175, were developed in an effort to facilitate this reductive process and accelerate the release of NO. SE 175 is stable in buffer or saline solution. In the intact rat, it stimulates endothelial soluble guanylate cyclase and induces aortic vasorelaxation with an EC50 of 20 µM, which is intermediate in potency between nitroglycerine and isosorbide dinitrate.{8459}
Brand:CaymanSKU:82340 - 50 mgAvailable on backorder
Se-Aspirin is a hybrid of selenium and a nonsteroidal anti-inflammatory drug that has been shown to reduce the viability of different cancer cell lines, particularly colorectal cancer (CRC) cells (IC50 = 3.4 µM).{31298} It can inhibit the cell cycle in G1 and G2/M phases and induce apoptosis by activating caspase 3/7 and PARP cleavage.{31298} Long-term exposure to Se-Aspirin is reported to cause an increase in intracellular reactive oxygen species levels in CRC cells.{31298}
Brand:CaymanSKU:-Available on backorder
Se-Aspirin is a hybrid of selenium and a nonsteroidal anti-inflammatory drug that has been shown to reduce the viability of different cancer cell lines, particularly colorectal cancer (CRC) cells (IC50 = 3.4 µM).{31298} It can inhibit the cell cycle in G1 and G2/M phases and induce apoptosis by activating caspase 3/7 and PARP cleavage.{31298} Long-term exposure to Se-Aspirin is reported to cause an increase in intracellular reactive oxygen species levels in CRC cells.{31298}
Brand:CaymanSKU:-Available on backorder
Se-Aspirin is a hybrid of selenium and a nonsteroidal anti-inflammatory drug that has been shown to reduce the viability of different cancer cell lines, particularly colorectal cancer (CRC) cells (IC50 = 3.4 µM).{31298} It can inhibit the cell cycle in G1 and G2/M phases and induce apoptosis by activating caspase 3/7 and PARP cleavage.{31298} Long-term exposure to Se-Aspirin is reported to cause an increase in intracellular reactive oxygen species levels in CRC cells.{31298}
Brand:CaymanSKU:-Available on backorder
Se-Aspirin is a hybrid of selenium and a nonsteroidal anti-inflammatory drug that has been shown to reduce the viability of different cancer cell lines, particularly colorectal cancer (CRC) cells (IC50 = 3.4 µM).{31298} It can inhibit the cell cycle in G1 and G2/M phases and induce apoptosis by activating caspase 3/7 and PARP cleavage.{31298} Long-term exposure to Se-Aspirin is reported to cause an increase in intracellular reactive oxygen species levels in CRC cells.{31298}
Brand:CaymanSKU:-Available on backorder
SEA0400 is a selective inhibitor of the Na+/Ca2+ exchanger (IC50s = 5, 8.3, and 33 nM for inhibiting Na+-dependent Ca2+ uptake in rat astrocyte, microglia, and cortical neuron cell lines, respectively).{31853} It is reported to prevent dopaminergic neurotoxicity in an MPTP mouse model of Parkinson’s disease and to attenuate reperfusion injury in both in vitro and in vivo cerebral ischemic models.{31854,31852}
Brand:CaymanSKU:19876 -Available on backorder
SEA0400 is a selective inhibitor of the Na+/Ca2+ exchanger (IC50s = 5, 8.3, and 33 nM for inhibiting Na+-dependent Ca2+ uptake in rat astrocyte, microglia, and cortical neuron cell lines, respectively).{31853} It is reported to prevent dopaminergic neurotoxicity in an MPTP mouse model of Parkinson’s disease and to attenuate reperfusion injury in both in vitro and in vivo cerebral ischemic models.{31854,31852}
Brand:CaymanSKU:19876 -Available on backorder
SEA0400 is a selective inhibitor of the Na+/Ca2+ exchanger (IC50s = 5, 8.3, and 33 nM for inhibiting Na+-dependent Ca2+ uptake in rat astrocyte, microglia, and cortical neuron cell lines, respectively).{31853} It is reported to prevent dopaminergic neurotoxicity in an MPTP mouse model of Parkinson’s disease and to attenuate reperfusion injury in both in vitro and in vivo cerebral ischemic models.{31854,31852}
Brand:CaymanSKU:19876 -Available on backorder