Cayman
Showing 38551–38700 of 45550 results
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Brand:CaymanSKU:601011 - 50 µlAvailable on backorder
SA 4503 is a sigma-1 (σ1) receptor agonist that is selective for σ1 over σ2 receptors in a radioligand binding assay using guinea pig brain homogenates (Kis = 4.6 and 63 nM, respectively).{45146,45147} SA 4503 (10 μM) reduces light-induced cell death, decreases in σ1 expression, disruption of the mitochondrial membrane potential, and activation of caspase-3/7 in murine 661W cells, effects that are blocked by the σ1 receptor antagonist BD 1047 (Item No. 22928).{45147} In vivo, SA 4503 (10 mg/kg) increases extracellular acetylcholine concentrations in the frontal cortex and improves step-through latency in a passive avoidance test in rats with scopolamine-induced memory impairment.{45148} SA 4503 reduces working and reference memory errors induced by a time delay and MK-801 (Item No. 10009019) in a radial arm maze in rats when administered at a dose of 0.3 mg/kg, effects which are ameliorated by the σ1 antagonist NE-100 (Item No. 19642).{45149} Pre-administration of SA 4503 (500 μM) into the intravitreal space reduces light-induced thinning of the mouse retina outer nuclear layer by approximately 50%. {45147}
Brand:CaymanSKU:26241 - 10 mgAvailable on backorder
SA 4503 is a sigma-1 (σ1) receptor agonist that is selective for σ1 over σ2 receptors in a radioligand binding assay using guinea pig brain homogenates (Kis = 4.6 and 63 nM, respectively).{45146,45147} SA 4503 (10 μM) reduces light-induced cell death, decreases in σ1 expression, disruption of the mitochondrial membrane potential, and activation of caspase-3/7 in murine 661W cells, effects that are blocked by the σ1 receptor antagonist BD 1047 (Item No. 22928).{45147} In vivo, SA 4503 (10 mg/kg) increases extracellular acetylcholine concentrations in the frontal cortex and improves step-through latency in a passive avoidance test in rats with scopolamine-induced memory impairment.{45148} SA 4503 reduces working and reference memory errors induced by a time delay and MK-801 (Item No. 10009019) in a radial arm maze in rats when administered at a dose of 0.3 mg/kg, effects which are ameliorated by the σ1 antagonist NE-100 (Item No. 19642).{45149} Pre-administration of SA 4503 (500 μM) into the intravitreal space reduces light-induced thinning of the mouse retina outer nuclear layer by approximately 50%. {45147}
Brand:CaymanSKU:26241 - 25 mgAvailable on backorder
SA 4503 is a sigma-1 (σ1) receptor agonist that is selective for σ1 over σ2 receptors in a radioligand binding assay using guinea pig brain homogenates (Kis = 4.6 and 63 nM, respectively).{45146,45147} SA 4503 (10 μM) reduces light-induced cell death, decreases in σ1 expression, disruption of the mitochondrial membrane potential, and activation of caspase-3/7 in murine 661W cells, effects that are blocked by the σ1 receptor antagonist BD 1047 (Item No. 22928).{45147} In vivo, SA 4503 (10 mg/kg) increases extracellular acetylcholine concentrations in the frontal cortex and improves step-through latency in a passive avoidance test in rats with scopolamine-induced memory impairment.{45148} SA 4503 reduces working and reference memory errors induced by a time delay and MK-801 (Item No. 10009019) in a radial arm maze in rats when administered at a dose of 0.3 mg/kg, effects which are ameliorated by the σ1 antagonist NE-100 (Item No. 19642).{45149} Pre-administration of SA 4503 (500 μM) into the intravitreal space reduces light-induced thinning of the mouse retina outer nuclear layer by approximately 50%. {45147}
Brand:CaymanSKU:26241 - 5 mgAvailable on backorder
SA 4503 is a sigma-1 (σ1) receptor agonist that is selective for σ1 over σ2 receptors in a radioligand binding assay using guinea pig brain homogenates (Kis = 4.6 and 63 nM, respectively).{45146,45147} SA 4503 (10 μM) reduces light-induced cell death, decreases in σ1 expression, disruption of the mitochondrial membrane potential, and activation of caspase-3/7 in murine 661W cells, effects that are blocked by the σ1 receptor antagonist BD 1047 (Item No. 22928).{45147} In vivo, SA 4503 (10 mg/kg) increases extracellular acetylcholine concentrations in the frontal cortex and improves step-through latency in a passive avoidance test in rats with scopolamine-induced memory impairment.{45148} SA 4503 reduces working and reference memory errors induced by a time delay and MK-801 (Item No. 10009019) in a radial arm maze in rats when administered at a dose of 0.3 mg/kg, effects which are ameliorated by the σ1 antagonist NE-100 (Item No. 19642).{45149} Pre-administration of SA 4503 (500 μM) into the intravitreal space reduces light-induced thinning of the mouse retina outer nuclear layer by approximately 50%. {45147}
Brand:CaymanSKU:26241 - 50 mgAvailable on backorder
SA 57 is an inhibitor of fatty acid amide hydrolase (FAAH; IC50s = 1.9 and 3.2 nM for hFAAH and mFAAH, respectively), monoacylglycerol lipase (MAGL; IC50s = 1,400 and 410 nM for hMAGL and mMAGL, respectively) and α/β-hydrolase domain-containing protein 6 (mABHD6; IC50 = 850 nM).{38148} In vivo, SA 57, at doses ≥1.25 mg/kg, selectively inactivates mFAAH and, at a dose of 12.5 mg/kg, inactivates mMAGL and mABHD6 resulting in a 10-fold increase in their substrates. Administration of SA 57 (5 mg/kg, i.p.) to morphine-dependent mice alleviates withdrawal signs without eliciting cannabimimetic side effects.{38149}
Brand:CaymanSKU:- SA 57 is an inhibitor of fatty acid amide hydrolase (FAAH; IC50s = 1.9 and 3.2 nM for hFAAH and mFAAH, respectively), monoacylglycerol lipase (MAGL; IC50s = 1,400 and 410 nM for hMAGL and mMAGL, respectively) and α/β-hydrolase domain-containing protein 6 (mABHD6; IC50 = 850 nM).{38148} In vivo, SA 57, at doses ≥1.25 mg/kg, selectively inactivates mFAAH and, at a dose of 12.5 mg/kg, inactivates mMAGL and mABHD6 resulting in a 10-fold increase in their substrates. Administration of SA 57 (5 mg/kg, i.p.) to morphine-dependent mice alleviates withdrawal signs without eliciting cannabimimetic side effects.{38149}
Brand:CaymanSKU:- SA 57 is an inhibitor of fatty acid amide hydrolase (FAAH; IC50s = 1.9 and 3.2 nM for hFAAH and mFAAH, respectively), monoacylglycerol lipase (MAGL; IC50s = 1,400 and 410 nM for hMAGL and mMAGL, respectively) and α/β-hydrolase domain-containing protein 6 (mABHD6; IC50 = 850 nM).{38148} In vivo, SA 57, at doses ≥1.25 mg/kg, selectively inactivates mFAAH and, at a dose of 12.5 mg/kg, inactivates mMAGL and mABHD6 resulting in a 10-fold increase in their substrates. Administration of SA 57 (5 mg/kg, i.p.) to morphine-dependent mice alleviates withdrawal signs without eliciting cannabimimetic side effects.{38149}
Brand:CaymanSKU:- SA 57 is an inhibitor of fatty acid amide hydrolase (FAAH; IC50s = 1.9 and 3.2 nM for hFAAH and mFAAH, respectively), monoacylglycerol lipase (MAGL; IC50s = 1,400 and 410 nM for hMAGL and mMAGL, respectively) and α/β-hydrolase domain-containing protein 6 (mABHD6; IC50 = 850 nM).{38148} In vivo, SA 57, at doses ≥1.25 mg/kg, selectively inactivates mFAAH and, at a dose of 12.5 mg/kg, inactivates mMAGL and mABHD6 resulting in a 10-fold increase in their substrates. Administration of SA 57 (5 mg/kg, i.p.) to morphine-dependent mice alleviates withdrawal signs without eliciting cannabimimetic side effects.{38149}
Brand:CaymanSKU:-
Sabinene is a bicyclic monoterpene found in a variety of plants, including Cannabis, that has antifungal and anti-inflammatory properties.{43357,43358,43359} It inhibits the growth of various fungi in vitro, including several species of Candida, Trichophyton, and Aspergillus (MICs = 0.16-5 μl/ml).{43359} Sabinene (0.32 μl/ml) prevents increases in nitrite production in RAW 264.7 macrophages stimulated by LPS and IFN-γ. It is cytotoxic to RAW 264.7 macrophages and HaCat keratinocytes when used at a concentration of 1.25 μl/ml. Formulations containing sabinene have been used as perfume additives.
Brand:CaymanSKU:25777 - 100 mgAvailable on backorder
Sabinene is a bicyclic monoterpene found in a variety of plants, including Cannabis, that has antifungal and anti-inflammatory properties.{43357,43358,43359} It inhibits the growth of various fungi in vitro, including several species of Candida, Trichophyton, and Aspergillus (MICs = 0.16-5 μl/ml).{43359} Sabinene (0.32 μl/ml) prevents increases in nitrite production in RAW 264.7 macrophages stimulated by LPS and IFN-γ. It is cytotoxic to RAW 264.7 macrophages and HaCat keratinocytes when used at a concentration of 1.25 μl/ml. Formulations containing sabinene have been used as perfume additives.
Brand:CaymanSKU:25777 - 25 mgAvailable on backorder
Sabinene is a bicyclic monoterpene found in a variety of plants, including Cannabis, that has antifungal and anti-inflammatory properties.{43357,43358,43359} It inhibits the growth of various fungi in vitro, including several species of Candida, Trichophyton, and Aspergillus (MICs = 0.16-5 μl/ml).{43359} Sabinene (0.32 μl/ml) prevents increases in nitrite production in RAW 264.7 macrophages stimulated by LPS and IFN-γ. It is cytotoxic to RAW 264.7 macrophages and HaCat keratinocytes when used at a concentration of 1.25 μl/ml. Formulations containing sabinene have been used as perfume additives.
Brand:CaymanSKU:25777 - 250 mgAvailable on backorder
Sabinene is a bicyclic monoterpene found in a variety of plants, including Cannabis, that has antifungal and anti-inflammatory properties.{43357,43358,43359} It inhibits the growth of various fungi in vitro, including several species of Candida, Trichophyton, and Aspergillus (MICs = 0.16-5 μl/ml).{43359} Sabinene (0.32 μl/ml) prevents increases in nitrite production in RAW 264.7 macrophages stimulated by LPS and IFN-γ. It is cytotoxic to RAW 264.7 macrophages and HaCat keratinocytes when used at a concentration of 1.25 μl/ml. Formulations containing sabinene have been used as perfume additives.
Brand:CaymanSKU:25777 - 50 mgAvailable on backorder
Saccharin 1-methylimidazole is a chemical activator that has been commonly used in solid-phase synthesis of DNA and RNA oligonucleotides.{46594} It catalyzes the phosphoramidite coupling reaction of the 5′ hydroxy of immobilized nucleosides and the amine group of nucleoside phosphoramidite. Saccharin 1-methylimidazole has been used to synthesize single-stranded DNA (ssDNA) oligonucleotides that are resistant to nuclease digestion.{46595}
Brand:CaymanSKU:29242 - 10 mgAvailable on backorder
Saccharin 1-methylimidazole is a chemical activator that has been commonly used in solid-phase synthesis of DNA and RNA oligonucleotides.{46594} It catalyzes the phosphoramidite coupling reaction of the 5′ hydroxy of immobilized nucleosides and the amine group of nucleoside phosphoramidite. Saccharin 1-methylimidazole has been used to synthesize single-stranded DNA (ssDNA) oligonucleotides that are resistant to nuclease digestion.{46595}
Brand:CaymanSKU:29242 - 25 mgAvailable on backorder
Saccharin 1-methylimidazole is a chemical activator that has been commonly used in solid-phase synthesis of DNA and RNA oligonucleotides.{46594} It catalyzes the phosphoramidite coupling reaction of the 5′ hydroxy of immobilized nucleosides and the amine group of nucleoside phosphoramidite. Saccharin 1-methylimidazole has been used to synthesize single-stranded DNA (ssDNA) oligonucleotides that are resistant to nuclease digestion.{46595}
Brand:CaymanSKU:29242 - 5 mgAvailable on backorder
Saccharin 1-methylimidazole is a chemical activator that has been commonly used in solid-phase synthesis of DNA and RNA oligonucleotides.{46594} It catalyzes the phosphoramidite coupling reaction of the 5′ hydroxy of immobilized nucleosides and the amine group of nucleoside phosphoramidite. Saccharin 1-methylimidazole has been used to synthesize single-stranded DNA (ssDNA) oligonucleotides that are resistant to nuclease digestion.{46595}
Brand:CaymanSKU:29242 - 50 mgAvailable on backorder
Saccharocarcin A is an antibiotic originally isolated from S. aerocolonigenes subsp. antibiotica.{35160} It is active against M. luteus, S. aureus, E. coli, P. aeruginosa, and C. albicans in a disc assay. Saccharocarcin A inhibits C. trachomatis infection by 88% without inducing cytotoxicity in McCoy cells when used at a concentration of 0.5 μg/ml.
Brand:CaymanSKU:28094 - 2.5 mgAvailable on backorder
Saccharocarcin A is an antibiotic originally isolated from S. aerocolonigenes subsp. antibiotica.{35160} It is active against M. luteus, S. aureus, E. coli, P. aeruginosa, and C. albicans in a disc assay. Saccharocarcin A inhibits C. trachomatis infection by 88% without inducing cytotoxicity in McCoy cells when used at a concentration of 0.5 μg/ml.
Brand:CaymanSKU:28094 - 500 µgAvailable on backorder
Saccharocarcin B is a macrocyclic lactone antibiotic that is active against the Gram-positive bacteria M. luteus and S. aureus as well as the Gram-negative bacteria C. trachomatis.{35160}
Brand:CaymanSKU:23861 - 2.5 mgAvailable on backorder
Saccharocarcin B is a macrocyclic lactone antibiotic that is active against the Gram-positive bacteria M. luteus and S. aureus as well as the Gram-negative bacteria C. trachomatis.{35160}
Brand:CaymanSKU:23861 - 500 µgAvailable on backorder
Saclofen is a sulfonic analog of the inhibitory neurotransmitter γ-aminobutyric acid (GABA) that acts as a competitive antagonist of the GABAB receptor (IC50 = 7.8 µM).{28352} This compound can be used to determine the functional roles for the GABAB receptor as a mediator of slow inhibitory postsynaptic potentials in the brain.
Brand:CaymanSKU:-Available on backorder
Saclofen is a sulfonic analog of the inhibitory neurotransmitter γ-aminobutyric acid (GABA) that acts as a competitive antagonist of the GABAB receptor (IC50 = 7.8 µM).{28352} This compound can be used to determine the functional roles for the GABAB receptor as a mediator of slow inhibitory postsynaptic potentials in the brain.
Brand:CaymanSKU:-Available on backorder
Saclofen is a sulfonic analog of the inhibitory neurotransmitter γ-aminobutyric acid (GABA) that acts as a competitive antagonist of the GABAB receptor (IC50 = 7.8 µM).{28352} This compound can be used to determine the functional roles for the GABAB receptor as a mediator of slow inhibitory postsynaptic potentials in the brain.
Brand:CaymanSKU:-Available on backorder
Safinamide is an inhibitor of monoamine oxidase B (MAO-B; IC50 = ~0.1 μM).{33890} It is selective for MAO-B over MAO-A (IC50 = >10 μM). It also inhibits radioligand binding to sodium channel binding site 2, sigma-1, and sigma-2 receptors in rat brain membranes (IC50s = 8.2, 0.019, and 1.59 μM, respectively).{46371} Safinamide inhibits high voltage-activated calcium currents and depolarization-induced tetrodotoxin-sensitive fast sodium currents in rat hippocampal neurons in a concentration-dependent manner. It inhibits veratrine-induced glutamate release in rat hippocampal slices (IC50 = 56 μM). Safinamide inhibits maximal electroshock-induced tonic extension seizures in mice and rats (ED50s = 8 and 11.8 mg/kg, p.o.) as well as maximal seizures induced by bicuculline (Item No. 11727), picrotoxin (Item No. 20771), 3-mercaptopropionic acid, and strychnine in mice (ED50s = 26.9, 60.6, 21.5, and 104.1 mg/kg, p.o., respectively).{46372} Formulations containing safinamide have been used as adjunctive treatments to levodopa and carbidopa in the treatment of “off” episodes associated with Parkinson’s disease.
Brand:CaymanSKU:21546 -Out of stock
Safinamide is an inhibitor of monoamine oxidase B (MAO-B; IC50 = ~0.1 μM).{33890} It is selective for MAO-B over MAO-A (IC50 = >10 μM). It also inhibits radioligand binding to sodium channel binding site 2, sigma-1, and sigma-2 receptors in rat brain membranes (IC50s = 8.2, 0.019, and 1.59 μM, respectively).{46371} Safinamide inhibits high voltage-activated calcium currents and depolarization-induced tetrodotoxin-sensitive fast sodium currents in rat hippocampal neurons in a concentration-dependent manner. It inhibits veratrine-induced glutamate release in rat hippocampal slices (IC50 = 56 μM). Safinamide inhibits maximal electroshock-induced tonic extension seizures in mice and rats (ED50s = 8 and 11.8 mg/kg, p.o.) as well as maximal seizures induced by bicuculline (Item No. 11727), picrotoxin (Item No. 20771), 3-mercaptopropionic acid, and strychnine in mice (ED50s = 26.9, 60.6, 21.5, and 104.1 mg/kg, p.o., respectively).{46372} Formulations containing safinamide have been used as adjunctive treatments to levodopa and carbidopa in the treatment of “off” episodes associated with Parkinson’s disease.
Brand:CaymanSKU:21546 -Out of stock
Safinamide is an inhibitor of monoamine oxidase B (MAO-B; IC50 = ~0.1 μM).{33890} It is selective for MAO-B over MAO-A (IC50 = >10 μM). It also inhibits radioligand binding to sodium channel binding site 2, sigma-1, and sigma-2 receptors in rat brain membranes (IC50s = 8.2, 0.019, and 1.59 μM, respectively).{46371} Safinamide inhibits high voltage-activated calcium currents and depolarization-induced tetrodotoxin-sensitive fast sodium currents in rat hippocampal neurons in a concentration-dependent manner. It inhibits veratrine-induced glutamate release in rat hippocampal slices (IC50 = 56 μM). Safinamide inhibits maximal electroshock-induced tonic extension seizures in mice and rats (ED50s = 8 and 11.8 mg/kg, p.o.) as well as maximal seizures induced by bicuculline (Item No. 11727), picrotoxin (Item No. 20771), 3-mercaptopropionic acid, and strychnine in mice (ED50s = 26.9, 60.6, 21.5, and 104.1 mg/kg, p.o., respectively).{46372} Formulations containing safinamide have been used as adjunctive treatments to levodopa and carbidopa in the treatment of “off” episodes associated with Parkinson’s disease.
Brand:CaymanSKU:21546 -Out of stock
Safinamide is an inhibitor of monoamine oxidase B (MAO-B; IC50 = ~0.1 μM).{33890} It is selective for MAO-B over MAO-A (IC50 = >10 μM). It also inhibits radioligand binding to sodium channel binding site 2, sigma-1, and sigma-2 receptors in rat brain membranes (IC50s = 8.2, 0.019, and 1.59 μM, respectively).{46371} Safinamide inhibits high voltage-activated calcium currents and depolarization-induced tetrodotoxin-sensitive fast sodium currents in rat hippocampal neurons in a concentration-dependent manner. It inhibits veratrine-induced glutamate release in rat hippocampal slices (IC50 = 56 μM). Safinamide inhibits maximal electroshock-induced tonic extension seizures in mice and rats (ED50s = 8 and 11.8 mg/kg, p.o.) as well as maximal seizures induced by bicuculline (Item No. 11727), picrotoxin (Item No. 20771), 3-mercaptopropionic acid, and strychnine in mice (ED50s = 26.9, 60.6, 21.5, and 104.1 mg/kg, p.o., respectively).{46372} Formulations containing safinamide have been used as adjunctive treatments to levodopa and carbidopa in the treatment of “off” episodes associated with Parkinson’s disease.
Brand:CaymanSKU:21546 -Out of stock
Safingol is the L-threo diastereomer of D-erythro-sphinganine (Item No. 10007945) and a dual inhibitor of PKC and sphingosine kinase (SPHK).{30406,24886} It inhibits PKC by binding at the regulatory phorbol-binding domain (IC50 = 24 µM).{30406} Safingol also inhibits SPHK (Ki = ~5 µM).{24886} Safingol (0.2-6 µM) restores sensitivity to cisplatin (Item No. 13119) in resistant AGScis5 cells and N87 gastric cancer cells in a concentration-dependent manner.{30405} [Matreya, LLC. Catalog No. 1807]
Brand:CaymanSKU:-Available on backorder
Safingol is the L-threo diastereomer of D-erythro-sphinganine (Item No. 10007945) and a dual inhibitor of PKC and sphingosine kinase (SPHK).{30406,24886} It inhibits PKC by binding at the regulatory phorbol-binding domain (IC50 = 24 µM).{30406} Safingol also inhibits SPHK (Ki = ~5 µM).{24886} Safingol (0.2-6 µM) restores sensitivity to cisplatin (Item No. 13119) in resistant AGScis5 cells and N87 gastric cancer cells in a concentration-dependent manner.{30405} [Matreya, LLC. Catalog No. 1807]
Brand:CaymanSKU:-Available on backorder
Safingol is the L-threo diastereomer of D-erythro-sphinganine (Item No. 10007945) and a dual inhibitor of PKC and sphingosine kinase (SPHK).{30406,24886} It inhibits PKC by binding at the regulatory phorbol-binding domain (IC50 = 24 µM).{30406} Safingol also inhibits SPHK (Ki = ~5 µM).{24886} Safingol (0.2-6 µM) restores sensitivity to cisplatin (Item No. 13119) in resistant AGScis5 cells and N87 gastric cancer cells in a concentration-dependent manner.{30405} [Matreya, LLC. Catalog No. 1807]
Brand:CaymanSKU:-Available on backorder
SAfit2 is a potent inhibitor of FK506-binding protein 51 (FKBP51; Ki = 6 nM).{40930} It is highly selective for FKBP51 over FKBP52 (Ki = >50,000 nM) and has increased brain permeability in comparison to SAfit1. SAfit2 (20 mg/kg) enhances HPA axis suppression in mice by decreasing plasma corticosterone levels to a greater extent than in control mice following dexamethasone administration. It also does not increase plasma corticosterone levels as high as in control mice following subsequent administration of corticotropin-releasing factor (CRF; Item No. 24407). It decreases the time spent immobile in the forced swim test and increases the time spent in the open arms of the elevated plus maze, indicating antidepressant-like and anxiolytic-like activity, respectfully.{40931}
Brand:CaymanSKU:24366 - 1 mgAvailable on backorder
SAfit2 is a potent inhibitor of FK506-binding protein 51 (FKBP51; Ki = 6 nM).{40930} It is highly selective for FKBP51 over FKBP52 (Ki = >50,000 nM) and has increased brain permeability in comparison to SAfit1. SAfit2 (20 mg/kg) enhances HPA axis suppression in mice by decreasing plasma corticosterone levels to a greater extent than in control mice following dexamethasone administration. It also does not increase plasma corticosterone levels as high as in control mice following subsequent administration of corticotropin-releasing factor (CRF; Item No. 24407). It decreases the time spent immobile in the forced swim test and increases the time spent in the open arms of the elevated plus maze, indicating antidepressant-like and anxiolytic-like activity, respectfully.{40931}
Brand:CaymanSKU:24366 - 5 mgAvailable on backorder
SAfit2 is a potent inhibitor of FK506-binding protein 51 (FKBP51; Ki = 6 nM).{40930} It is highly selective for FKBP51 over FKBP52 (Ki = >50,000 nM) and has increased brain permeability in comparison to SAfit1. SAfit2 (20 mg/kg) enhances HPA axis suppression in mice by decreasing plasma corticosterone levels to a greater extent than in control mice following dexamethasone administration. It also does not increase plasma corticosterone levels as high as in control mice following subsequent administration of corticotropin-releasing factor (CRF; Item No. 24407). It decreases the time spent immobile in the forced swim test and increases the time spent in the open arms of the elevated plus maze, indicating antidepressant-like and anxiolytic-like activity, respectfully.{40931}
Brand:CaymanSKU:24366 - 500 µgAvailable on backorder
Safranal is a monoterpenoid that has been found in C. sativus and has diverse biological activities, including microtubule polymerization inhibitory, cancer cell growth inhibitory, and antioxidant properties.{61077,61078,61079,61080} It decreases microtubule polymerization in a cell-free assay (IC50 = 72.19 µM) and inhibits the growth of HeLa cells (IC50 = 95 µM).{61077,61078} Safranal (145.5, 363.75, and 727.5 mg/kg) reduces the levels of thiobarbituric acid reactive substances (TBARS) and malondialdehyde (MDA) in the hippocampus in a rat model of global cerebral ischemia.{61079} It also reduces convulsions induced by pentylenetetrazole (Item No. 18682) in mice.{61080}
Brand:CaymanSKU:31399 - 1 gAvailable on backorder
Safranal is a monoterpenoid that has been found in C. sativus and has diverse biological activities, including microtubule polymerization inhibitory, cancer cell growth inhibitory, and antioxidant properties.{61077,61078,61079,61080} It decreases microtubule polymerization in a cell-free assay (IC50 = 72.19 µM) and inhibits the growth of HeLa cells (IC50 = 95 µM).{61077,61078} Safranal (145.5, 363.75, and 727.5 mg/kg) reduces the levels of thiobarbituric acid reactive substances (TBARS) and malondialdehyde (MDA) in the hippocampus in a rat model of global cerebral ischemia.{61079} It also reduces convulsions induced by pentylenetetrazole (Item No. 18682) in mice.{61080}
Brand:CaymanSKU:31399 - 10 gAvailable on backorder
Safranal is a monoterpenoid that has been found in C. sativus and has diverse biological activities, including microtubule polymerization inhibitory, cancer cell growth inhibitory, and antioxidant properties.{61077,61078,61079,61080} It decreases microtubule polymerization in a cell-free assay (IC50 = 72.19 µM) and inhibits the growth of HeLa cells (IC50 = 95 µM).{61077,61078} Safranal (145.5, 363.75, and 727.5 mg/kg) reduces the levels of thiobarbituric acid reactive substances (TBARS) and malondialdehyde (MDA) in the hippocampus in a rat model of global cerebral ischemia.{61079} It also reduces convulsions induced by pentylenetetrazole (Item No. 18682) in mice.{61080}
Brand:CaymanSKU:31399 - 25 gAvailable on backorder
Safranal is a monoterpenoid that has been found in C. sativus and has diverse biological activities, including microtubule polymerization inhibitory, cancer cell growth inhibitory, and antioxidant properties.{61077,61078,61079,61080} It decreases microtubule polymerization in a cell-free assay (IC50 = 72.19 µM) and inhibits the growth of HeLa cells (IC50 = 95 µM).{61077,61078} Safranal (145.5, 363.75, and 727.5 mg/kg) reduces the levels of thiobarbituric acid reactive substances (TBARS) and malondialdehyde (MDA) in the hippocampus in a rat model of global cerebral ischemia.{61079} It also reduces convulsions induced by pentylenetetrazole (Item No. 18682) in mice.{61080}
Brand:CaymanSKU:31399 - 5 gAvailable on backorder
Smoothened agonist (SAG) is a chlorobenzothiophene-containing compound which acts as a SMO agonist (EC50 = 3 nM) but inhibits hedgehog signaling at high concentrations (>1 μM).{21771} It directly binds to SMO and can block SMO inhibition by cyclopamine.{21771} Binding of SAG alters the conformation of SMO, leading to its accumulation in cilia and activation of gene transcription.{20488,21775,21773} At 15-240 nM, SAG prevents the neurotoxic effects of glucocorticoids without interfering with the beneficial effects of glucocorticoids on lung maturation.{21772} At higher concentrations (0.4 mM), SAG improves the conversion of human induced pluripotent stem cells to the neural lineage.{21770}
Brand:CaymanSKU:11914 - 1 mgAvailable on backorder
Smoothened agonist (SAG) is a chlorobenzothiophene-containing compound which acts as a SMO agonist (EC50 = 3 nM) but inhibits hedgehog signaling at high concentrations (>1 μM).{21771} It directly binds to SMO and can block SMO inhibition by cyclopamine.{21771} Binding of SAG alters the conformation of SMO, leading to its accumulation in cilia and activation of gene transcription.{20488,21775,21773} At 15-240 nM, SAG prevents the neurotoxic effects of glucocorticoids without interfering with the beneficial effects of glucocorticoids on lung maturation.{21772} At higher concentrations (0.4 mM), SAG improves the conversion of human induced pluripotent stem cells to the neural lineage.{21770}
Brand:CaymanSKU:11914 - 10 mgAvailable on backorder
Smoothened agonist (SAG) is a chlorobenzothiophene-containing compound which acts as a SMO agonist (EC50 = 3 nM) but inhibits hedgehog signaling at high concentrations (>1 μM).{21771} It directly binds to SMO and can block SMO inhibition by cyclopamine.{21771} Binding of SAG alters the conformation of SMO, leading to its accumulation in cilia and activation of gene transcription.{20488,21775,21773} At 15-240 nM, SAG prevents the neurotoxic effects of glucocorticoids without interfering with the beneficial effects of glucocorticoids on lung maturation.{21772} At higher concentrations (0.4 mM), SAG improves the conversion of human induced pluripotent stem cells to the neural lineage.{21770}
Brand:CaymanSKU:11914 - 5 mgAvailable on backorder
SAGE-217 is a positive allosteric modulator of GABAA receptors.{59529} It potentiates GABA-induced currents in LTK cells expressing α4β2γ2 subunit-containing GABAA receptors and CHO cells expressing α4β3δ subunit-containing GABAA receptors (EC50s = 375 and 299 nM, respectively). SAGE-217 (0.3-10 mg/kg, i.p.) reduces the number of seizures induced by pentylenetetrazole (PTZ; Item No. 18682) in mice. It also inhibits electrographic and behavioral seizure activity in a rat model of lithium-pilocarpine induced status epilepticus.
Brand:CaymanSKU:31755 - 1 mgAvailable on backorder
SAGE-217 is a positive allosteric modulator of GABAA receptors.{59529} It potentiates GABA-induced currents in LTK cells expressing α4β2γ2 subunit-containing GABAA receptors and CHO cells expressing α4β3δ subunit-containing GABAA receptors (EC50s = 375 and 299 nM, respectively). SAGE-217 (0.3-10 mg/kg, i.p.) reduces the number of seizures induced by pentylenetetrazole (PTZ; Item No. 18682) in mice. It also inhibits electrographic and behavioral seizure activity in a rat model of lithium-pilocarpine induced status epilepticus.
Brand:CaymanSKU:31755 - 10 mgAvailable on backorder
SAGE-217 is a positive allosteric modulator of GABAA receptors.{59529} It potentiates GABA-induced currents in LTK cells expressing α4β2γ2 subunit-containing GABAA receptors and CHO cells expressing α4β3δ subunit-containing GABAA receptors (EC50s = 375 and 299 nM, respectively). SAGE-217 (0.3-10 mg/kg, i.p.) reduces the number of seizures induced by pentylenetetrazole (PTZ; Item No. 18682) in mice. It also inhibits electrographic and behavioral seizure activity in a rat model of lithium-pilocarpine induced status epilepticus.
Brand:CaymanSKU:31755 - 25 mgAvailable on backorder
SAGE-217 is a positive allosteric modulator of GABAA receptors.{59529} It potentiates GABA-induced currents in LTK cells expressing α4β2γ2 subunit-containing GABAA receptors and CHO cells expressing α4β3δ subunit-containing GABAA receptors (EC50s = 375 and 299 nM, respectively). SAGE-217 (0.3-10 mg/kg, i.p.) reduces the number of seizures induced by pentylenetetrazole (PTZ; Item No. 18682) in mice. It also inhibits electrographic and behavioral seizure activity in a rat model of lithium-pilocarpine induced status epilepticus.
Brand:CaymanSKU:31755 - 5 mgAvailable on backorder
SAHA is a histone deacetylase (HDAC) inhibitor that binds directly to the catalytic site of the enzyme thereby blocking substrate access. It inhibits class I, II, and IV HDACs at 50-200 nM and arrests cell growth in a wide variety of transformed cells in culture at 2.5-5.0 µM.{14739}
Brand:CaymanSKU:10009929 - 1 gAvailable on backorder
SAHA is a histone deacetylase (HDAC) inhibitor that binds directly to the catalytic site of the enzyme thereby blocking substrate access. It inhibits class I, II, and IV HDACs at 50-200 nM and arrests cell growth in a wide variety of transformed cells in culture at 2.5-5.0 µM.{14739}
Brand:CaymanSKU:10009929 - 100 mgAvailable on backorder
SAHA is a histone deacetylase (HDAC) inhibitor that binds directly to the catalytic site of the enzyme thereby blocking substrate access. It inhibits class I, II, and IV HDACs at 50-200 nM and arrests cell growth in a wide variety of transformed cells in culture at 2.5-5.0 µM.{14739}
Brand:CaymanSKU:10009929 - 250 mgAvailable on backorder
SAHA is a histone deacetylase (HDAC) inhibitor that binds directly to the catalytic site of the enzyme thereby blocking substrate access. It inhibits class I, II, and IV HDACs at 50-200 nM and arrests cell growth in a wide variety of transformed cells in culture at 2.5-5.0 µM.{14739}
Brand:CaymanSKU:10009929 - 500 mgAvailable on backorder
Suberoylanilide hydroxamic acid (SAHA) is a class I and class II histone deacetylase (HDAC) inhibitor that binds directly to the catalytic site of the enzyme thereby blocking substrate access.{14739} SAHA-BPyne is a SAHA derivative with a benzophenone crosslinker and an alkyne tag intended to be used for profiling HDAC activities in proteomes and live cells.{15936,19509} Such terminal alkyne groups can be used in linking reactions, known as click chemistry, characterized by high dependability and specificity of azide-alkyne bioconjugation reactions.{17991,17992} SAHA-BPyne labels HDAC complex proteins both in proteomes at 100 nM and in live cells at 500 nM and demonstrates an IC50 value of ~3 μM for inhibition of HDAC activity in HeLa cell nuclear lysates in an HDAC activity assay.{15936}
Brand:CaymanSKU:10675 - 1 mgAvailable on backorder
Suberoylanilide hydroxamic acid (SAHA) is a class I and class II histone deacetylase (HDAC) inhibitor that binds directly to the catalytic site of the enzyme thereby blocking substrate access.{14739} SAHA-BPyne is a SAHA derivative with a benzophenone crosslinker and an alkyne tag intended to be used for profiling HDAC activities in proteomes and live cells.{15936,19509} Such terminal alkyne groups can be used in linking reactions, known as click chemistry, characterized by high dependability and specificity of azide-alkyne bioconjugation reactions.{17991,17992} SAHA-BPyne labels HDAC complex proteins both in proteomes at 100 nM and in live cells at 500 nM and demonstrates an IC50 value of ~3 μM for inhibition of HDAC activity in HeLa cell nuclear lysates in an HDAC activity assay.{15936}
Brand:CaymanSKU:10675 - 100 µgAvailable on backorder
Suberoylanilide hydroxamic acid (SAHA) is a class I and class II histone deacetylase (HDAC) inhibitor that binds directly to the catalytic site of the enzyme thereby blocking substrate access.{14739} SAHA-BPyne is a SAHA derivative with a benzophenone crosslinker and an alkyne tag intended to be used for profiling HDAC activities in proteomes and live cells.{15936,19509} Such terminal alkyne groups can be used in linking reactions, known as click chemistry, characterized by high dependability and specificity of azide-alkyne bioconjugation reactions.{17991,17992} SAHA-BPyne labels HDAC complex proteins both in proteomes at 100 nM and in live cells at 500 nM and demonstrates an IC50 value of ~3 μM for inhibition of HDAC activity in HeLa cell nuclear lysates in an HDAC activity assay.{15936}
Brand:CaymanSKU:10675 - 5 mgAvailable on backorder
SAHA-d5 contains five deuterium atoms at the 2, 3, 4, 5, and 6 positions. It is intended for use as an internal standard for the quantification of SAHA (suberoylanilide hydroxamic acid; Item No. 10009929) by GC- or LC-MS. SAHA is a histone deacetylase (HDAC) inhibitor that binds directly to the catalytic site of the enzyme thereby blocking substrate access. It inhibits class I, II, and IV HDACs at 50-200 nM and arrests cell growth in a wide variety of transformed cells in culture at 2.5-5.0 µM.{14739}
Brand:CaymanSKU:22107 -Out of stock
SAHA-d5 contains five deuterium atoms at the 2, 3, 4, 5, and 6 positions. It is intended for use as an internal standard for the quantification of SAHA (suberoylanilide hydroxamic acid; Item No. 10009929) by GC- or LC-MS. SAHA is a histone deacetylase (HDAC) inhibitor that binds directly to the catalytic site of the enzyme thereby blocking substrate access. It inhibits class I, II, and IV HDACs at 50-200 nM and arrests cell growth in a wide variety of transformed cells in culture at 2.5-5.0 µM.{14739}
Brand:CaymanSKU:22107 -Out of stock
SAHO is a sulfoxide form of the methyl donor S-(5′-adenosyl)-L-methionine chloride (SAM; Item No. 13956) and a substrate for radical SAM enzymes.{50175} It is reductively cleaved to S-adenosylhomocysteine (SAH; Item No. 13603), 5′-deoxyadenosine (Item No. 29619), and 5′-thioadenosine sulfenic acid by the radical SAM enzymes NosL or NosN.
Brand:CaymanSKU:28725 - 1 mgAvailable on backorder
SAHO is a sulfoxide form of the methyl donor S-(5′-adenosyl)-L-methionine chloride (SAM; Item No. 13956) and a substrate for radical SAM enzymes.{50175} It is reductively cleaved to S-adenosylhomocysteine (SAH; Item No. 13603), 5′-deoxyadenosine (Item No. 29619), and 5′-thioadenosine sulfenic acid by the radical SAM enzymes NosL or NosN.
Brand:CaymanSKU:28725 - 5 mgAvailable on backorder
SAHO2 is a sulfone form of the methyl donor S-(5′-adenosyl)-L-methionine chloride (SAM; Item No. 13956) and is a substrate for radical SAM enzymes.{50175} It is reductively cleaved to 5′-deoxyadenosine (Item No. 29619) and 5′-thioadenosine sulfinic acid by the radical SAM enzymes NosL or NosN.
Brand:CaymanSKU:28726 - 1 mgAvailable on backorder
SAHO2 is a sulfone form of the methyl donor S-(5′-adenosyl)-L-methionine chloride (SAM; Item No. 13956) and is a substrate for radical SAM enzymes.{50175} It is reductively cleaved to 5′-deoxyadenosine (Item No. 29619) and 5′-thioadenosine sulfinic acid by the radical SAM enzymes NosL or NosN.
Brand:CaymanSKU:28726 - 5 mgAvailable on backorder
SAICAR is an intermediate in the de novo purine nucleotide synthesis pathway. It is reported to stimulate pyruvate kinase isoform M2 and to promote cancer cell survival in conditions of limited glucose availability.{21962}
Brand:CaymanSKU:-
Saikosaponin A is a triterpenoid saponin with diverse biological activities, including anti-inflammatory, antiallergic, anticonvulsive, antiproliferative, and antiviral properties.{34440,42259,42260,42262} Saikosaponin A reduces expression of TNF-α, IL-6, and IL-1β in primary mouse macrophages stimulated by LPS.{42257} It also increases the survival rate in mice with LPS-induced lethal endotoxemia in a dose-dependent manner.{42257} Saikosaponin A (20 mg/kg, i.v., per day) reduces weight loss, brain edema, blood-brain barrier disruption, and IL-6 and TNF-α protein levels in the ipsilateral cortex compared to control animals in a rat model of traumatic brain injury.{42258} It also reduces the number of nasal rubs and levels of serum TNF-α in an ovalbumin-sensitized allergic rhinitis mouse model in vivo when administered at a dose of 8 mg/kg.{42259} It reduces the duration and frequency of epileptiform activity in rat hippocampal CA1 neurons in a dose-dependent manner in a 4-aminopyridine (4-AP; Item No. 18511) seizure model.{42260} Saikosaponin A (20 µM) decreases viability in six human colon carcinoma (HCC), H358 lung and MCF-7 breast cancer, as well as Jurkat and K582 leukemia cell lines.{42261} It also prolongs tumor growth inhibition in LoVo and SW480 HCC mouse xenograft models in vivo when used at a dose of 2 mg/kg.
Brand:CaymanSKU:25026 - 1 mgAvailable on backorder
Saikosaponin A is a triterpenoid saponin with diverse biological activities, including anti-inflammatory, antiallergic, anticonvulsive, antiproliferative, and antiviral properties.{34440,42259,42260,42262} Saikosaponin A reduces expression of TNF-α, IL-6, and IL-1β in primary mouse macrophages stimulated by LPS.{42257} It also increases the survival rate in mice with LPS-induced lethal endotoxemia in a dose-dependent manner.{42257} Saikosaponin A (20 mg/kg, i.v., per day) reduces weight loss, brain edema, blood-brain barrier disruption, and IL-6 and TNF-α protein levels in the ipsilateral cortex compared to control animals in a rat model of traumatic brain injury.{42258} It also reduces the number of nasal rubs and levels of serum TNF-α in an ovalbumin-sensitized allergic rhinitis mouse model in vivo when administered at a dose of 8 mg/kg.{42259} It reduces the duration and frequency of epileptiform activity in rat hippocampal CA1 neurons in a dose-dependent manner in a 4-aminopyridine (4-AP; Item No. 18511) seizure model.{42260} Saikosaponin A (20 µM) decreases viability in six human colon carcinoma (HCC), H358 lung and MCF-7 breast cancer, as well as Jurkat and K582 leukemia cell lines.{42261} It also prolongs tumor growth inhibition in LoVo and SW480 HCC mouse xenograft models in vivo when used at a dose of 2 mg/kg.
Brand:CaymanSKU:25026 - 10 mgAvailable on backorder
Saikosaponin A is a triterpenoid saponin with diverse biological activities, including anti-inflammatory, antiallergic, anticonvulsive, antiproliferative, and antiviral properties.{34440,42259,42260,42262} Saikosaponin A reduces expression of TNF-α, IL-6, and IL-1β in primary mouse macrophages stimulated by LPS.{42257} It also increases the survival rate in mice with LPS-induced lethal endotoxemia in a dose-dependent manner.{42257} Saikosaponin A (20 mg/kg, i.v., per day) reduces weight loss, brain edema, blood-brain barrier disruption, and IL-6 and TNF-α protein levels in the ipsilateral cortex compared to control animals in a rat model of traumatic brain injury.{42258} It also reduces the number of nasal rubs and levels of serum TNF-α in an ovalbumin-sensitized allergic rhinitis mouse model in vivo when administered at a dose of 8 mg/kg.{42259} It reduces the duration and frequency of epileptiform activity in rat hippocampal CA1 neurons in a dose-dependent manner in a 4-aminopyridine (4-AP; Item No. 18511) seizure model.{42260} Saikosaponin A (20 µM) decreases viability in six human colon carcinoma (HCC), H358 lung and MCF-7 breast cancer, as well as Jurkat and K582 leukemia cell lines.{42261} It also prolongs tumor growth inhibition in LoVo and SW480 HCC mouse xenograft models in vivo when used at a dose of 2 mg/kg.
Brand:CaymanSKU:25026 - 25 mgAvailable on backorder
Saikosaponin A is a triterpenoid saponin with diverse biological activities, including anti-inflammatory, antiallergic, anticonvulsive, antiproliferative, and antiviral properties.{34440,42259,42260,42262} Saikosaponin A reduces expression of TNF-α, IL-6, and IL-1β in primary mouse macrophages stimulated by LPS.{42257} It also increases the survival rate in mice with LPS-induced lethal endotoxemia in a dose-dependent manner.{42257} Saikosaponin A (20 mg/kg, i.v., per day) reduces weight loss, brain edema, blood-brain barrier disruption, and IL-6 and TNF-α protein levels in the ipsilateral cortex compared to control animals in a rat model of traumatic brain injury.{42258} It also reduces the number of nasal rubs and levels of serum TNF-α in an ovalbumin-sensitized allergic rhinitis mouse model in vivo when administered at a dose of 8 mg/kg.{42259} It reduces the duration and frequency of epileptiform activity in rat hippocampal CA1 neurons in a dose-dependent manner in a 4-aminopyridine (4-AP; Item No. 18511) seizure model.{42260} Saikosaponin A (20 µM) decreases viability in six human colon carcinoma (HCC), H358 lung and MCF-7 breast cancer, as well as Jurkat and K582 leukemia cell lines.{42261} It also prolongs tumor growth inhibition in LoVo and SW480 HCC mouse xenograft models in vivo when used at a dose of 2 mg/kg.
Brand:CaymanSKU:25026 - 5 mgAvailable on backorder
Sakuranetin is a flavonoid and phytoalexin that has been found in rice and has diverse biological activities.{34183,53873,34186,34182} It reduces blast fungus mycelium growth in vitro and decreases the number of fungal lesions and fungal DNA in blast fungus-infected rice leaves when applied at concentrations of 0.1 and 0.2 mM.{34183} Sakuranetin is active against M. luteus and B. subtilis (MICs = 2 and 0.5 µg/ml, respectively).{53873} It is cytotoxic to KB nasopharyngal carcinoma cells (EC50 = 10 µg/ml). Sakuranetin (20 mg/kg) reduces alveolar enlargement, collagen and elastic fiber deposition, and bronchoalveolar lavage fluid (BALF) levels of TNF-α, IL-1β, and M-CSF in a mouse model of elastase-induced emphysema.{34186} It also reduces collagen fiber deposition and lung inflammation in a mouse model of LPS-induced acute lung injury.{34182}
Brand:CaymanSKU:19761 -Available on backorder
Sakuranetin is a flavonoid and phytoalexin that has been found in rice and has diverse biological activities.{34183,53873,34186,34182} It reduces blast fungus mycelium growth in vitro and decreases the number of fungal lesions and fungal DNA in blast fungus-infected rice leaves when applied at concentrations of 0.1 and 0.2 mM.{34183} Sakuranetin is active against M. luteus and B. subtilis (MICs = 2 and 0.5 µg/ml, respectively).{53873} It is cytotoxic to KB nasopharyngal carcinoma cells (EC50 = 10 µg/ml). Sakuranetin (20 mg/kg) reduces alveolar enlargement, collagen and elastic fiber deposition, and bronchoalveolar lavage fluid (BALF) levels of TNF-α, IL-1β, and M-CSF in a mouse model of elastase-induced emphysema.{34186} It also reduces collagen fiber deposition and lung inflammation in a mouse model of LPS-induced acute lung injury.{34182}
Brand:CaymanSKU:19761 -Available on backorder
Sakuranetin is a flavonoid and phytoalexin that has been found in rice and has diverse biological activities.{34183,53873,34186,34182} It reduces blast fungus mycelium growth in vitro and decreases the number of fungal lesions and fungal DNA in blast fungus-infected rice leaves when applied at concentrations of 0.1 and 0.2 mM.{34183} Sakuranetin is active against M. luteus and B. subtilis (MICs = 2 and 0.5 µg/ml, respectively).{53873} It is cytotoxic to KB nasopharyngal carcinoma cells (EC50 = 10 µg/ml). Sakuranetin (20 mg/kg) reduces alveolar enlargement, collagen and elastic fiber deposition, and bronchoalveolar lavage fluid (BALF) levels of TNF-α, IL-1β, and M-CSF in a mouse model of elastase-induced emphysema.{34186} It also reduces collagen fiber deposition and lung inflammation in a mouse model of LPS-induced acute lung injury.{34182}
Brand:CaymanSKU:19761 -Available on backorder
Sakuranetin is a flavonoid and phytoalexin that has been found in rice and has diverse biological activities.{34183,53873,34186,34182} It reduces blast fungus mycelium growth in vitro and decreases the number of fungal lesions and fungal DNA in blast fungus-infected rice leaves when applied at concentrations of 0.1 and 0.2 mM.{34183} Sakuranetin is active against M. luteus and B. subtilis (MICs = 2 and 0.5 µg/ml, respectively).{53873} It is cytotoxic to KB nasopharyngal carcinoma cells (EC50 = 10 µg/ml). Sakuranetin (20 mg/kg) reduces alveolar enlargement, collagen and elastic fiber deposition, and bronchoalveolar lavage fluid (BALF) levels of TNF-α, IL-1β, and M-CSF in a mouse model of elastase-induced emphysema.{34186} It also reduces collagen fiber deposition and lung inflammation in a mouse model of LPS-induced acute lung injury.{34182}
Brand:CaymanSKU:19761 -Available on backorder
Sal-003 dose-dependently prevents dephosphorylation of eukaryotic translation initiation factor 2 subunit α (eIF2α).{38357} It is a more potent derivative of salubrinal (Item No. 14735) that increases eIF2α phosphorylation in mouse embryonic fibroblasts (MEFs) when used at a concentration of 10 µM.{38356} It impairs late-phase long-term potentiation (LTP) in hippocampal slices from wild-type, but not ATF4 knockout, mice. When infused into the dorsal hippocampus post-training, Sal-003 impairs contextual fear memory in rats.
Brand:CaymanSKU:23414 - 10 mgAvailable on backorder
Sal-003 dose-dependently prevents dephosphorylation of eukaryotic translation initiation factor 2 subunit α (eIF2α).{38357} It is a more potent derivative of salubrinal (Item No. 14735) that increases eIF2α phosphorylation in mouse embryonic fibroblasts (MEFs) when used at a concentration of 10 µM.{38356} It impairs late-phase long-term potentiation (LTP) in hippocampal slices from wild-type, but not ATF4 knockout, mice. When infused into the dorsal hippocampus post-training, Sal-003 impairs contextual fear memory in rats.
Brand:CaymanSKU:23414 - 5 mgAvailable on backorder
Salazinic acid is a depsidone lichen metabolite that has been found in P. sulcata.{48819} It is active against B. cereus, B. subtilis, S. aureus, P. aeruginosa, S. typhimurium, C. albicans, and A. niger in vitro (MICs = 3.9-30.8 mM). Salazinic acid is cytotoxic to MM98, A431, and HaCaT cells in crystal violet (EC50s = 159, 2,870, and 48 μM, respectively) and neutral red uptake assays (EC50s = 1,925, 1,913, and 907 μM, respectively).{50294} It increases the wound closure rate in scratch-wounded HaCaT monolayers and increases HaCaT cell migration in a transwell assay when used at a concentration of 30 μM.
Brand:CaymanSKU:29885 - 1 mgAvailable on backorder
Salazinic acid is a depsidone lichen metabolite that has been found in P. sulcata.{48819} It is active against B. cereus, B. subtilis, S. aureus, P. aeruginosa, S. typhimurium, C. albicans, and A. niger in vitro (MICs = 3.9-30.8 mM). Salazinic acid is cytotoxic to MM98, A431, and HaCaT cells in crystal violet (EC50s = 159, 2,870, and 48 μM, respectively) and neutral red uptake assays (EC50s = 1,925, 1,913, and 907 μM, respectively).{50294} It increases the wound closure rate in scratch-wounded HaCaT monolayers and increases HaCaT cell migration in a transwell assay when used at a concentration of 30 μM.
Brand:CaymanSKU:29885 - 5 mgAvailable on backorder
Salbutamol is an agonist of the β2-adrenergic receptor (β2-AR; Kd = 759 nM in a radioligand binding assay using CHO cells expressing the human receptor).{25151} It is selective for β2-ARs over β1- and β3-ARs (Kds = 46.8 and 21.9 μM, respectively). Salbutamol (25-50 μg/kg, i.v.) reduces acetylcholine-induced bronchospasm in anesthetized guinea pigs.{40769} It also reduces response of bronchial muscle to efferent vagal stimulation in anesthetized cats and dogs when administered at doses ranging from 1 to 2.5 and 10 to 20 μg/kg, respectively. Nebulized salbutamol reduces transpulmonary pressure in recurrent airway obstruction-affected horses (EC50 = 39.7 μg).{40770} Formulations containing salbutamol have been used in the treatment of asthma and chronic obstructive pulmonary disease (COPD).
Brand:CaymanSKU:21003 -Out of stock
Salbutamol is an agonist of the β2-adrenergic receptor (β2-AR; Kd = 759 nM in a radioligand binding assay using CHO cells expressing the human receptor).{25151} It is selective for β2-ARs over β1- and β3-ARs (Kds = 46.8 and 21.9 μM, respectively). Salbutamol (25-50 μg/kg, i.v.) reduces acetylcholine-induced bronchospasm in anesthetized guinea pigs.{40769} It also reduces response of bronchial muscle to efferent vagal stimulation in anesthetized cats and dogs when administered at doses ranging from 1 to 2.5 and 10 to 20 μg/kg, respectively. Nebulized salbutamol reduces transpulmonary pressure in recurrent airway obstruction-affected horses (EC50 = 39.7 μg).{40770} Formulations containing salbutamol have been used in the treatment of asthma and chronic obstructive pulmonary disease (COPD).
Brand:CaymanSKU:21003 -Out of stock
Salbutamol is an agonist of the β2-adrenergic receptor (β2-AR; Kd = 759 nM in a radioligand binding assay using CHO cells expressing the human receptor).{25151} It is selective for β2-ARs over β1- and β3-ARs (Kds = 46.8 and 21.9 μM, respectively). Salbutamol (25-50 μg/kg, i.v.) reduces acetylcholine-induced bronchospasm in anesthetized guinea pigs.{40769} It also reduces response of bronchial muscle to efferent vagal stimulation in anesthetized cats and dogs when administered at doses ranging from 1 to 2.5 and 10 to 20 μg/kg, respectively. Nebulized salbutamol reduces transpulmonary pressure in recurrent airway obstruction-affected horses (EC50 = 39.7 μg).{40770} Formulations containing salbutamol have been used in the treatment of asthma and chronic obstructive pulmonary disease (COPD).
Brand:CaymanSKU:21003 -Out of stock
Salbutamol is an agonist of the β2-adrenergic receptor (β2-AR; Kd = 759 nM in a radioligand binding assay using CHO cells expressing the human receptor).{25151} It is selective for β2-ARs over β1- and β3-ARs (Kds = 46.8 and 21.9 μM, respectively). Salbutamol (25-50 μg/kg, i.v.) reduces acetylcholine-induced bronchospasm in anesthetized guinea pigs.{40769} It also reduces response of bronchial muscle to efferent vagal stimulation in anesthetized cats and dogs when administered at doses ranging from 1 to 2.5 and 10 to 20 μg/kg, respectively. Nebulized salbutamol reduces transpulmonary pressure in recurrent airway obstruction-affected horses (EC50 = 39.7 μg).{40770} Formulations containing salbutamol have been used in the treatment of asthma and chronic obstructive pulmonary disease (COPD).
Brand:CaymanSKU:21003 -Out of stock
Salbutamol is an agonist of the β2-adrenergic receptor (β2-AR; Kd = 759 nM in a radioligand binding assay using CHO cells expressing the human receptor).{25151} It is selective for β2-ARs over β1- and β3-ARs (Kds = 46.8 and 21.9 μM, respectively). Salbutamol (25-50 μg/kg, i.v.) reduces acetylcholine-induced bronchospasm in anesthetized guinea pigs.{40769} It also reduces response of bronchial muscle to efferent vagal stimulation in anesthetized cats and dogs when administered at doses ranging from 1 to 2.5 and 10 to 20 μg/kg, respectively. Nebulized salbutamol reduces transpulmonary pressure in recurrent airway obstruction-affected horses (EC50 = 39.7 μg).{40770} Formulations containing salbutamol have been used in the treatment of asthma and chronic obstructive pulmonary disease (COPD).
Brand:CaymanSKU:23991 - 10 mgAvailable on backorder
Salbutamol is an agonist of the β2-adrenergic receptor (β2-AR; Kd = 759 nM in a radioligand binding assay using CHO cells expressing the human receptor).{25151} It is selective for β2-ARs over β1- and β3-ARs (Kds = 46.8 and 21.9 μM, respectively). Salbutamol (25-50 μg/kg, i.v.) reduces acetylcholine-induced bronchospasm in anesthetized guinea pigs.{40769} It also reduces response of bronchial muscle to efferent vagal stimulation in anesthetized cats and dogs when administered at doses ranging from 1 to 2.5 and 10 to 20 μg/kg, respectively. Nebulized salbutamol reduces transpulmonary pressure in recurrent airway obstruction-affected horses (EC50 = 39.7 μg).{40770} Formulations containing salbutamol have been used in the treatment of asthma and chronic obstructive pulmonary disease (COPD).
Brand:CaymanSKU:23991 - 25 mgAvailable on backorder
Salbutamol is an agonist of the β2-adrenergic receptor (β2-AR; Kd = 759 nM in a radioligand binding assay using CHO cells expressing the human receptor).{25151} It is selective for β2-ARs over β1- and β3-ARs (Kds = 46.8 and 21.9 μM, respectively). Salbutamol (25-50 μg/kg, i.v.) reduces acetylcholine-induced bronchospasm in anesthetized guinea pigs.{40769} It also reduces response of bronchial muscle to efferent vagal stimulation in anesthetized cats and dogs when administered at doses ranging from 1 to 2.5 and 10 to 20 μg/kg, respectively. Nebulized salbutamol reduces transpulmonary pressure in recurrent airway obstruction-affected horses (EC50 = 39.7 μg).{40770} Formulations containing salbutamol have been used in the treatment of asthma and chronic obstructive pulmonary disease (COPD).
Brand:CaymanSKU:23991 - 5 mgAvailable on backorder
Salbutamol is an agonist of the β2-adrenergic receptor (β2-AR; Kd = 759 nM in a radioligand binding assay using CHO cells expressing the human receptor).{25151} It is selective for β2-ARs over β1- and β3-ARs (Kds = 46.8 and 21.9 μM, respectively). Salbutamol (25-50 μg/kg, i.v.) reduces acetylcholine-induced bronchospasm in anesthetized guinea pigs.{40769} It also reduces response of bronchial muscle to efferent vagal stimulation in anesthetized cats and dogs when administered at doses ranging from 1 to 2.5 and 10 to 20 μg/kg, respectively. Nebulized salbutamol reduces transpulmonary pressure in recurrent airway obstruction-affected horses (EC50 = 39.7 μg).{40770} Formulations containing salbutamol have been used in the treatment of asthma and chronic obstructive pulmonary disease (COPD).
Brand:CaymanSKU:23991 - 50 mgAvailable on backorder
Salbutamol-d9 is intended for use as an internal standard for the quantification of salbutamol (Item Nos. 21003 | 23991) by GC- or LC-MS. Salbutamol is an agonist of the β2-adrenergic receptor (β2-AR; Kd = 759 nM in a radioligand binding assay using CHO cells expressing the human receptor).{25151} It is selective for β2-ARs over β1- and β3-ARs (Kds = 46.8 and 21.9 µM, respectively). Salbutamol (25-50 μg/kg, i.v.) reduces acetylcholine-induced bronchospasm in anesthetized guinea pigs.{40769} It also reduces response of bronchial muscle to efferent vagal stimulation in anesthetized cats and dogs when administered at doses ranging from 1 to 2.5 and 10 to 20 µg/kg, respectively. Nebulized salbutamol reduces transpulmonary pressure in recurrent airway obstruction-affected horses (EC50 = 39.7 µg).{40770} Formulations containing salbutamol have been used in the treatment of asthma and chronic obstructive pulmonary disease (COPD).
Brand:CaymanSKU:25234 - 1 mgAvailable on backorder
Salbutamol-d9 is intended for use as an internal standard for the quantification of salbutamol (Item Nos. 21003 | 23991) by GC- or LC-MS. Salbutamol is an agonist of the β2-adrenergic receptor (β2-AR; Kd = 759 nM in a radioligand binding assay using CHO cells expressing the human receptor).{25151} It is selective for β2-ARs over β1- and β3-ARs (Kds = 46.8 and 21.9 µM, respectively). Salbutamol (25-50 μg/kg, i.v.) reduces acetylcholine-induced bronchospasm in anesthetized guinea pigs.{40769} It also reduces response of bronchial muscle to efferent vagal stimulation in anesthetized cats and dogs when administered at doses ranging from 1 to 2.5 and 10 to 20 µg/kg, respectively. Nebulized salbutamol reduces transpulmonary pressure in recurrent airway obstruction-affected horses (EC50 = 39.7 µg).{40770} Formulations containing salbutamol have been used in the treatment of asthma and chronic obstructive pulmonary disease (COPD).
Brand:CaymanSKU:25234 - 500 µgAvailable on backorder