Cayman
Showing 37051–37200 of 45550 results
-
Quinacrine (Item No. 15041) is a compound with multiple actions that is commonly used as an anti-protozoal agent. It has also been shown to be a highly potent autophagy inhibitor, although the dose required to achieve this effect is considerably cytotoxic (LD50 = 2.5 µM).{30438} Quinacrine analog 34 is a derivative of quinacrine that was designed with an improved cell viability profile (LD50 = 27 µM) to inhibit autophagy.{30438} At a minimum concentration of 0.5 µM, this compound has been shown to increase the protein levels of the autophagy biomarker LC3-II and to induce lysosome deacidification.{30438}
Brand:CaymanSKU:-Available on backorder
Quinacrine (Item No. 15041) is a compound with multiple actions that is commonly used as an anti-protozoal agent. It has also been shown to be a highly potent autophagy inhibitor, although the dose required to achieve this effect is considerably cytotoxic (LD50 = 2.5 µM).{30438} Quinacrine analog 34 is a derivative of quinacrine that was designed with an improved cell viability profile (LD50 = 27 µM) to inhibit autophagy.{30438} At a minimum concentration of 0.5 µM, this compound has been shown to increase the protein levels of the autophagy biomarker LC3-II and to induce lysosome deacidification.{30438}
Brand:CaymanSKU:-Available on backorder
Quinacrine (Item No. 15041) is a compound with multiple actions that is commonly used as an anti-protozoal agent. It has also been shown to be a highly potent autophagy inhibitor, although the dose required to achieve this effect is considerably cytotoxic (LD50 = 2.5 µM).{30438} Quinacrine analog 34 is a derivative of quinacrine that was designed with an improved cell viability profile (LD50 = 27 µM) to inhibit autophagy.{30438} At a minimum concentration of 0.5 µM, this compound has been shown to increase the protein levels of the autophagy biomarker LC3-II and to induce lysosome deacidification.{30438}
Brand:CaymanSKU:-Available on backorder
Quinacrine mustard is a fluorescent DNA-intercalating agent.{53187} It selectively binds to adenine-thymine (AT) base pairs over guanine-cytosine (GC) base pairs.{53186,53188} Quinacrine mustard has been used to label metaphase chromosomes for karyotyping by autoradiography.{53187} It displays excitation/emission maxima of 425/480 nm, respectively.{53189}
Brand:CaymanSKU:29653 - 10 mgAvailable on backorder
Quinacrine mustard is a fluorescent DNA-intercalating agent.{53187} It selectively binds to adenine-thymine (AT) base pairs over guanine-cytosine (GC) base pairs.{53186,53188} Quinacrine mustard has been used to label metaphase chromosomes for karyotyping by autoradiography.{53187} It displays excitation/emission maxima of 425/480 nm, respectively.{53189}
Brand:CaymanSKU:29653 - 25 mgAvailable on backorder
Quinacrine mustard is a fluorescent DNA-intercalating agent.{53187} It selectively binds to adenine-thymine (AT) base pairs over guanine-cytosine (GC) base pairs.{53186,53188} Quinacrine mustard has been used to label metaphase chromosomes for karyotyping by autoradiography.{53187} It displays excitation/emission maxima of 425/480 nm, respectively.{53189}
Brand:CaymanSKU:29653 - 5 mgAvailable on backorder
Quinacrine mustard is a fluorescent DNA-intercalating agent.{53187} It selectively binds to adenine-thymine (AT) base pairs over guanine-cytosine (GC) base pairs.{53186,53188} Quinacrine mustard has been used to label metaphase chromosomes for karyotyping by autoradiography.{53187} It displays excitation/emission maxima of 425/480 nm, respectively.{53189}
Brand:CaymanSKU:29653 - 50 mgAvailable on backorder
Quinaldopeptin is a quinomycin antibiotic.{45259} It is active against a variety of bacteria, including S. pyogenes, S. aureus, C. perfringens, S. faecalis, E. coli, and K. pneumoniae (MICs = 0.2, 0.4, 0.8, 1.6, 3.1, and 6.3 µg/ml, respectively). It is cytotoxic to B16/F10 and Moser cells (IC50s = 0.0008 and 0.04 µg/ml, respectively) and increases survival in a P388 leukemia mouse model. Quinaldopeptin is a bis-intercalator depsipeptide (NPBID) that binds to and intercalates into DNA (Kd = 32 nM).{45260}
Brand:CaymanSKU:28167 - 2.5 mgAvailable on backorder
Quinaldopeptin is a quinomycin antibiotic.{45259} It is active against a variety of bacteria, including S. pyogenes, S. aureus, C. perfringens, S. faecalis, E. coli, and K. pneumoniae (MICs = 0.2, 0.4, 0.8, 1.6, 3.1, and 6.3 µg/ml, respectively). It is cytotoxic to B16/F10 and Moser cells (IC50s = 0.0008 and 0.04 µg/ml, respectively) and increases survival in a P388 leukemia mouse model. Quinaldopeptin is a bis-intercalator depsipeptide (NPBID) that binds to and intercalates into DNA (Kd = 32 nM).{45260}
Brand:CaymanSKU:28167 - 500 µgAvailable on backorder
Quinapril is a prodrug to the angiotensin converting enzyme inhibitor quinaprilat (pKis = 9.25 and 9.92 in human heart and lung plasma membrane preparations, respectively).{30687} It has been shown to inhibit the contractile and pressor effects of angiotensin I in rabbit aorta and in rats, respectively, and to lower blood pressure in rodent and dog models of hypertension.{33593}
Brand:CaymanSKU:21439 -Out of stock
Quinapril is a prodrug to the angiotensin converting enzyme inhibitor quinaprilat (pKis = 9.25 and 9.92 in human heart and lung plasma membrane preparations, respectively).{30687} It has been shown to inhibit the contractile and pressor effects of angiotensin I in rabbit aorta and in rats, respectively, and to lower blood pressure in rodent and dog models of hypertension.{33593}
Brand:CaymanSKU:21439 -Out of stock
Quinapril is a prodrug to the angiotensin converting enzyme inhibitor quinaprilat (pKis = 9.25 and 9.92 in human heart and lung plasma membrane preparations, respectively).{30687} It has been shown to inhibit the contractile and pressor effects of angiotensin I in rabbit aorta and in rats, respectively, and to lower blood pressure in rodent and dog models of hypertension.{33593}
Brand:CaymanSKU:21439 -Out of stock
Quinapril is a prodrug to the angiotensin converting enzyme inhibitor quinaprilat (pKis = 9.25 and 9.92 in human heart and lung plasma membrane preparations, respectively).{30687} It has been shown to inhibit the contractile and pressor effects of angiotensin I in rabbit aorta and in rats, respectively, and to lower blood pressure in rodent and dog models of hypertension.{33593}
Brand:CaymanSKU:21439 -Out of stock
Quinestrol is a synthetic estrogen that is effective in hormone replacement therapy.{14114,14115} It is a 3-cyclopentyl ether of ethynyl estradiol. After gastrointestinal absorption, it is stored in adipose tissue, where it is slowly released and metabolized in the liver to its active form, ethinyl estradiol. Quinestrol has found limited use in suppressing lactation in postpartum women and, in combination with synthetic progestogens, as contraceptive therapy, although additional studies are needed for both applications.
Brand:CaymanSKU:10006320 - 1 gAvailable on backorder
Quinestrol is a synthetic estrogen that is effective in hormone replacement therapy.{14114,14115} It is a 3-cyclopentyl ether of ethynyl estradiol. After gastrointestinal absorption, it is stored in adipose tissue, where it is slowly released and metabolized in the liver to its active form, ethinyl estradiol. Quinestrol has found limited use in suppressing lactation in postpartum women and, in combination with synthetic progestogens, as contraceptive therapy, although additional studies are needed for both applications.
Brand:CaymanSKU:10006320 - 100 mgAvailable on backorder
Quinestrol is a synthetic estrogen that is effective in hormone replacement therapy.{14114,14115} It is a 3-cyclopentyl ether of ethynyl estradiol. After gastrointestinal absorption, it is stored in adipose tissue, where it is slowly released and metabolized in the liver to its active form, ethinyl estradiol. Quinestrol has found limited use in suppressing lactation in postpartum women and, in combination with synthetic progestogens, as contraceptive therapy, although additional studies are needed for both applications.
Brand:CaymanSKU:10006320 - 250 mgAvailable on backorder
Quinestrol is a synthetic estrogen that is effective in hormone replacement therapy.{14114,14115} It is a 3-cyclopentyl ether of ethynyl estradiol. After gastrointestinal absorption, it is stored in adipose tissue, where it is slowly released and metabolized in the liver to its active form, ethinyl estradiol. Quinestrol has found limited use in suppressing lactation in postpartum women and, in combination with synthetic progestogens, as contraceptive therapy, although additional studies are needed for both applications.
Brand:CaymanSKU:10006320 - 500 mgAvailable on backorder
Quinidine is a stereoisomer of the antimalarial agent quinine (Item No. 23958) and a class Ia antiarrhythmic agent.{37790,37791} Quinidine blocks the voltage-gated sodium (Nav) channel Nav1.5 in a use-dependent manner.{37790} It decreases the amplitude and duration of action potentials in isolated canine ventricular myocytes.{37792} It inhibits KKr, peak INa, and late INa (IC50s = 4.5, 11, and 12 µM, respectively) and can induce torsade de pointes in isolated rabbit hearts when used at a concentration of 1 µM.{37791} Quinidine induces QT prolongation in dogs.{37793} It also binds to M2 muscarinic acetylcholine receptors (Ki = 7.5 µM for human recombinant receptors expressed in HM2-B10 cells).{37794} Formulations containing quinidine have been used in the treatment of atrial fibrillation and ventricular arrhythmias.
Brand:CaymanSKU:20356 -Available on backorder
Quinidine is a stereoisomer of the antimalarial agent quinine (Item No. 23958) and a class Ia antiarrhythmic agent.{37790,37791} Quinidine blocks the voltage-gated sodium (Nav) channel Nav1.5 in a use-dependent manner.{37790} It decreases the amplitude and duration of action potentials in isolated canine ventricular myocytes.{37792} It inhibits KKr, peak INa, and late INa (IC50s = 4.5, 11, and 12 µM, respectively) and can induce torsade de pointes in isolated rabbit hearts when used at a concentration of 1 µM.{37791} Quinidine induces QT prolongation in dogs.{37793} It also binds to M2 muscarinic acetylcholine receptors (Ki = 7.5 µM for human recombinant receptors expressed in HM2-B10 cells).{37794} Formulations containing quinidine have been used in the treatment of atrial fibrillation and ventricular arrhythmias.
Brand:CaymanSKU:20356 -Available on backorder
Quinidine is a stereoisomer of the antimalarial agent quinine (Item No. 23958) and a class Ia antiarrhythmic agent.{37790,37791} Quinidine blocks the voltage-gated sodium (Nav) channel Nav1.5 in a use-dependent manner.{37790} It decreases the amplitude and duration of action potentials in isolated canine ventricular myocytes.{37792} It inhibits KKr, peak INa, and late INa (IC50s = 4.5, 11, and 12 µM, respectively) and can induce torsade de pointes in isolated rabbit hearts when used at a concentration of 1 µM.{37791} Quinidine induces QT prolongation in dogs.{37793} It also binds to M2 muscarinic acetylcholine receptors (Ki = 7.5 µM for human recombinant receptors expressed in HM2-B10 cells).{37794} Formulations containing quinidine have been used in the treatment of atrial fibrillation and ventricular arrhythmias.
Brand:CaymanSKU:20356 -Available on backorder
Quinidine is a stereoisomer of the antimalarial agent quinine (Item No. 23958) and a class Ia antiarrhythmic agent.{37790,37791} Quinidine blocks the voltage-gated sodium (Nav) channel Nav1.5 in a use-dependent manner.{37790} It decreases the amplitude and duration of action potentials in isolated canine ventricular myocytes.{37792} It inhibits KKr, peak INa, and late INa (IC50s = 4.5, 11, and 12 µM, respectively) and can induce torsade de pointes in isolated rabbit hearts when used at a concentration of 1 µM.{37791} Quinidine induces QT prolongation in dogs.{37793} It also binds to M2 muscarinic acetylcholine receptors (Ki = 7.5 µM for human recombinant receptors expressed in HM2-B10 cells).{37794} Formulations containing quinidine have been used in the treatment of atrial fibrillation and ventricular arrhythmias.
Brand:CaymanSKU:20356 -Available on backorder
Quinidine N-oxide is a pharmacologically inactive quinidine metabolite.{38061} Quinidine, an antiarrhythmic agent, undergoes rapid first-pass metabolism by the cytochrome P450 isoforms CYP3A4, CYP2C9, and CYP2E1, with CYP3A4 being the most active enzyme in quinidine N-oxide formation.{38062}
Brand:CaymanSKU:22381 -Out of stock
Quinidine N-oxide is a pharmacologically inactive quinidine metabolite.{38061} Quinidine, an antiarrhythmic agent, undergoes rapid first-pass metabolism by the cytochrome P450 isoforms CYP3A4, CYP2C9, and CYP2E1, with CYP3A4 being the most active enzyme in quinidine N-oxide formation.{38062}
Brand:CaymanSKU:22381 -Out of stock
Quinidine N-oxide is a pharmacologically inactive quinidine metabolite.{38061} Quinidine, an antiarrhythmic agent, undergoes rapid first-pass metabolism by the cytochrome P450 isoforms CYP3A4, CYP2C9, and CYP2E1, with CYP3A4 being the most active enzyme in quinidine N-oxide formation.{38062}
Brand:CaymanSKU:22381 -Out of stock
Quinidine-d3 is intended for use as an internal standard for the quantification of quinidine (Item No. 20356) by GC- or LC-MS. Quinidine is a stereoisomer of the antimalarial agent quinine (Item No. 23958) and a class Ia antiarrhythmic agent.{37790,37791} Quinidine blocks the voltage-gated sodium (Nav) channel Nav1.5 in a use-dependent manner.{37790} It decreases the amplitude and duration of action potentials in isolated canine ventricular myocytes.{37792} Quinidine inhibits KKr, peak INa, and late INa (IC50s = 4.5, 11, and 12 µM, respectively) and can induce torsade de pointes in isolated rabbit hearts when used at a concentration of 1 µM.{37791} It induces QT prolongation in dogs.{37793} Quinidine also binds to M2 muscarinic acetylcholine receptors (Ki = 7.5 µM for human recombinant receptors expressed in HM2-B10 cells).{37794} Formulations containing quinidine have been used in the treatment of atrial fibrillation and ventricular arrhythmias.
Brand:CaymanSKU:28884 - 2.5 mgAvailable on backorder
Quinine is an alkaloid antimalarial agent that has MIC values ranging from 10 to 500 nM for 60 Thai isolates of P. falciparum.{39572} It inhibits hemozoin formation in purified trophozoites, leading to an increase in free heme, similar to the mechanism of action of chloroquine (Item No. 14194).{38381} In mice, quinine reduces P. berghei parasite load in the blood with a minimum effective dose (MED) of 150 mg/kg.{39573} Formulations containing quinine have been used in the treatment of uncomplicated malaria.
Brand:CaymanSKU:23958 - 1 gAvailable on backorder
Quinine is an alkaloid antimalarial agent that has MIC values ranging from 10 to 500 nM for 60 Thai isolates of P. falciparum.{39572} It inhibits hemozoin formation in purified trophozoites, leading to an increase in free heme, similar to the mechanism of action of chloroquine (Item No. 14194).{38381} In mice, quinine reduces P. berghei parasite load in the blood with a minimum effective dose (MED) of 150 mg/kg.{39573} Formulations containing quinine have been used in the treatment of uncomplicated malaria.
Brand:CaymanSKU:23958 - 10 gAvailable on backorder
Quinine is an alkaloid antimalarial agent that has MIC values ranging from 10 to 500 nM for 60 Thai isolates of P. falciparum.{39572} It inhibits hemozoin formation in purified trophozoites, leading to an increase in free heme, similar to the mechanism of action of chloroquine (Item No. 14194).{38381} In mice, quinine reduces P. berghei parasite load in the blood with a minimum effective dose (MED) of 150 mg/kg.{39573} Formulations containing quinine have been used in the treatment of uncomplicated malaria.
Brand:CaymanSKU:23958 - 25 gAvailable on backorder
Quinine is an alkaloid antimalarial agent that has MIC values ranging from 10 to 500 nM for 60 Thai isolates of P. falciparum.{39572} It inhibits hemozoin formation in purified trophozoites, leading to an increase in free heme, similar to the mechanism of action of chloroquine (Item No. 14194).{38381} In mice, quinine reduces P. berghei parasite load in the blood with a minimum effective dose (MED) of 150 mg/kg.{39573} Formulations containing quinine have been used in the treatment of uncomplicated malaria.
Brand:CaymanSKU:23958 - 5 gAvailable on backorder
Quininib is an antagonist of the cysteinyl leukotriene 1 (CysLT1) and CysLT2 receptors (IC50s = 1.4 and 52 µM, respectively).{49221} It inhibits tubule formation in HMEC-1 cells when used at concentrations of 3.16 and 10 µM and inhibits sprout formation in isolated mouse aortic rings in an ex vivo model of angiogenesis when used at 10 µM. Quininib (3 µM) decreases angiogenesis in an oxygen-induced retinopathy mouse model of ocular angiogenesis, preventing revascularization when used at concentrations of 0.5 and 3 µM, as well as increasing neovascularization and vascular density when used at 3 µM. It reduces tumor growth and inhibits angiogenesis in an HT-29 colorectal cancer mouse xenograft model when administered at a dose of 50 mg/kg every three days.{49222}
Brand:CaymanSKU:19838 -Available on backorder
Quininib is an antagonist of the cysteinyl leukotriene 1 (CysLT1) and CysLT2 receptors (IC50s = 1.4 and 52 µM, respectively).{49221} It inhibits tubule formation in HMEC-1 cells when used at concentrations of 3.16 and 10 µM and inhibits sprout formation in isolated mouse aortic rings in an ex vivo model of angiogenesis when used at 10 µM. Quininib (3 µM) decreases angiogenesis in an oxygen-induced retinopathy mouse model of ocular angiogenesis, preventing revascularization when used at concentrations of 0.5 and 3 µM, as well as increasing neovascularization and vascular density when used at 3 µM. It reduces tumor growth and inhibits angiogenesis in an HT-29 colorectal cancer mouse xenograft model when administered at a dose of 50 mg/kg every three days.{49222}
Brand:CaymanSKU:19838 -Available on backorder
Quininib is an antagonist of the cysteinyl leukotriene 1 (CysLT1) and CysLT2 receptors (IC50s = 1.4 and 52 µM, respectively).{49221} It inhibits tubule formation in HMEC-1 cells when used at concentrations of 3.16 and 10 µM and inhibits sprout formation in isolated mouse aortic rings in an ex vivo model of angiogenesis when used at 10 µM. Quininib (3 µM) decreases angiogenesis in an oxygen-induced retinopathy mouse model of ocular angiogenesis, preventing revascularization when used at concentrations of 0.5 and 3 µM, as well as increasing neovascularization and vascular density when used at 3 µM. It reduces tumor growth and inhibits angiogenesis in an HT-29 colorectal cancer mouse xenograft model when administered at a dose of 50 mg/kg every three days.{49222}
Brand:CaymanSKU:19838 -Available on backorder
Quininib is an antagonist of the cysteinyl leukotriene 1 (CysLT1) and CysLT2 receptors (IC50s = 1.4 and 52 µM, respectively).{49221} It inhibits tubule formation in HMEC-1 cells when used at concentrations of 3.16 and 10 µM and inhibits sprout formation in isolated mouse aortic rings in an ex vivo model of angiogenesis when used at 10 µM. Quininib (3 µM) decreases angiogenesis in an oxygen-induced retinopathy mouse model of ocular angiogenesis, preventing revascularization when used at concentrations of 0.5 and 3 µM, as well as increasing neovascularization and vascular density when used at 3 µM. It reduces tumor growth and inhibits angiogenesis in an HT-29 colorectal cancer mouse xenograft model when administered at a dose of 50 mg/kg every three days.{49222}
Brand:CaymanSKU:19838 -Available on backorder
Quinolactactin A is a quinolone fungal metabolite originally isolated from Penicillium.{45191} It inhibits TNF production induced by LPS in murine peritoneal macrophages (IC50 = 12.2 µg/ml). It is not active against a variety of bacteria, fungi, and yeasts. Quinolactacin A is a mixture of quinolactacin A1 and A2.
Brand:CaymanSKU:27701 - 1 mgAvailable on backorder
Quinolactactin A is a quinolone fungal metabolite originally isolated from Penicillium.{45191} It inhibits TNF production induced by LPS in murine peritoneal macrophages (IC50 = 12.2 µg/ml). It is not active against a variety of bacteria, fungi, and yeasts. Quinolactacin A is a mixture of quinolactacin A1 and A2.
Brand:CaymanSKU:27701 - 5 mgAvailable on backorder
Quinolactactin A is a quinolone fungal metabolite originally isolated from Penicillium.{45191} It inhibits TNF production induced by LPS in murine peritoneal macrophages (IC50 = 12.2 µg/ml). It is not active against a variety of bacteria, fungi, and yeasts. Quinolactacin A is a mixture of quinolactacin A1 and A2.
Brand:CaymanSKU:27701 - 500 µgAvailable on backorder
Quinolinic acid is an endogenous agonist at NMDA receptors that is generated through the metabolism of tryptophan in the kynurenine pathway.{23856} By overactivating NMDA receptors, quinolinic acid produces neurotoxicity, which has been implicated in certain neurodegenerative disorders.{20572} Quinolinic acid can also generate reactive oxygen species, has immunomodulatory actions, and promotes the formation of hyperphosphorylated tau proteins.{6411,5945,23005}
Brand:CaymanSKU:- Quinolinic acid is an endogenous agonist at NMDA receptors that is generated through the metabolism of tryptophan in the kynurenine pathway.{23856} By overactivating NMDA receptors, quinolinic acid produces neurotoxicity, which has been implicated in certain neurodegenerative disorders.{20572} Quinolinic acid can also generate reactive oxygen species, has immunomodulatory actions, and promotes the formation of hyperphosphorylated tau proteins.{6411,5945,23005}
Brand:CaymanSKU:- Quinolinic acid is an endogenous agonist at NMDA receptors that is generated through the metabolism of tryptophan in the kynurenine pathway.{23856} By overactivating NMDA receptors, quinolinic acid produces neurotoxicity, which has been implicated in certain neurodegenerative disorders.{20572} Quinolinic acid can also generate reactive oxygen species, has immunomodulatory actions, and promotes the formation of hyperphosphorylated tau proteins.{6411,5945,23005}
Brand:CaymanSKU:-
Quinupristin is a streptogramin antibiotic that blocks peptide bond formation and peptide extension in bacteria.{27025,22680} Quinupristin is usually combined with another streptogramin antibiotic, dalfopristin (Item No. 19762), to produce quinupristin-dalfopristin complex (Item No. 19763), known commercially as Synercid. While both quinupristin and dalfopristin have bacteriostatic effects, they act synergistically to kill Gram-positive bacteria, as well as some Gram-negative and anaerobic bacteria.{31495,22680}
Brand:CaymanSKU:19764 -Available on backorder
Quinupristin is a streptogramin antibiotic that blocks peptide bond formation and peptide extension in bacteria.{27025,22680} Quinupristin is usually combined with another streptogramin antibiotic, dalfopristin (Item No. 19762), to produce quinupristin-dalfopristin complex (Item No. 19763), known commercially as Synercid. While both quinupristin and dalfopristin have bacteriostatic effects, they act synergistically to kill Gram-positive bacteria, as well as some Gram-negative and anaerobic bacteria.{31495,22680}
Brand:CaymanSKU:19764 -Available on backorder
Quizartinib is an inhibitor of FMS-related tyrosine kinase 3 (FLT3; Kd = 1.6 nM) and demonstrates high selectivity for FLT3 when tested against a panel of 227 additional kinases.{30966,30967} It inhibits the proliferation of the human leukemia cell line MV4-11, which harbors a homozygous FLT3-ITD mutation, with an IC50 value of 0.56 nM.{30966} At 1 mg/kg/day, quizartinib has been shown to extend survival in a mouse model of FLT3-ITD acute myeloid leukemia and to eradicate tumors in an FLT3-dependent mouse xenograft model at 10 mg/kg.{30967}
Brand:CaymanSKU:-Available on backorder
Quizartinib is an inhibitor of FMS-related tyrosine kinase 3 (FLT3; Kd = 1.6 nM) and demonstrates high selectivity for FLT3 when tested against a panel of 227 additional kinases.{30966,30967} It inhibits the proliferation of the human leukemia cell line MV4-11, which harbors a homozygous FLT3-ITD mutation, with an IC50 value of 0.56 nM.{30966} At 1 mg/kg/day, quizartinib has been shown to extend survival in a mouse model of FLT3-ITD acute myeloid leukemia and to eradicate tumors in an FLT3-dependent mouse xenograft model at 10 mg/kg.{30967}
Brand:CaymanSKU:-Available on backorder
Quizartinib is an inhibitor of FMS-related tyrosine kinase 3 (FLT3; Kd = 1.6 nM) and demonstrates high selectivity for FLT3 when tested against a panel of 227 additional kinases.{30966,30967} It inhibits the proliferation of the human leukemia cell line MV4-11, which harbors a homozygous FLT3-ITD mutation, with an IC50 value of 0.56 nM.{30966} At 1 mg/kg/day, quizartinib has been shown to extend survival in a mouse model of FLT3-ITD acute myeloid leukemia and to eradicate tumors in an FLT3-dependent mouse xenograft model at 10 mg/kg.{30967}
Brand:CaymanSKU:-Available on backorder
Quizartinib is an inhibitor of FMS-related tyrosine kinase 3 (FLT3; Kd = 1.6 nM) and demonstrates high selectivity for FLT3 when tested against a panel of 227 additional kinases.{30966,30967} It inhibits the proliferation of the human leukemia cell line MV4-11, which harbors a homozygous FLT3-ITD mutation, with an IC50 value of 0.56 nM.{30966} At 1 mg/kg/day, quizartinib has been shown to extend survival in a mouse model of FLT3-ITD acute myeloid leukemia and to eradicate tumors in an FLT3-dependent mouse xenograft model at 10 mg/kg.{30967}
Brand:CaymanSKU:-Available on backorder
QX-314 is a membrane-impermeant lidocaine derivative that selectively blocks sodium channels on nociceptive neurons when delivered intracellularly via the TRPV1 channel, but is reportedly ineffective with extracellular application.{15625} When supplied in combination with 1 µM capsaicin, a TRPV1 receptor agonist, 5 mM QX-314 blocks 98% of sodium current in voltage-clamped nociceptive DRG neurons.{15625} QX-314 elicits a long-lasting decrease in the response to painful mechanical and thermal stimuli without imparting the motor deficits (e.g., numbness, paralysis) associated with many conventional local anesthetics.{15625} At concentrations ranging from 10-70 mM, peripheral application of QX-314 dose-dependently produces robust local anesthesia with slow onset in the guinea pig intradermal wheal assay, the murine tail-flick test, and the murine sciatic nerve blockade model.{16613} However, injection of 0.5-30 mM QX-314 in the lumbar intrathecal space produces neurotoxicity and death in mice.{16615}
Brand:CaymanSKU:10011032 - 100 mgAvailable on backorder
QX-314 is a membrane-impermeant lidocaine derivative that selectively blocks sodium channels on nociceptive neurons when delivered intracellularly via the TRPV1 channel, but is reportedly ineffective with extracellular application.{15625} When supplied in combination with 1 µM capsaicin, a TRPV1 receptor agonist, 5 mM QX-314 blocks 98% of sodium current in voltage-clamped nociceptive DRG neurons.{15625} QX-314 elicits a long-lasting decrease in the response to painful mechanical and thermal stimuli without imparting the motor deficits (e.g., numbness, paralysis) associated with many conventional local anesthetics.{15625} At concentrations ranging from 10-70 mM, peripheral application of QX-314 dose-dependently produces robust local anesthesia with slow onset in the guinea pig intradermal wheal assay, the murine tail-flick test, and the murine sciatic nerve blockade model.{16613} However, injection of 0.5-30 mM QX-314 in the lumbar intrathecal space produces neurotoxicity and death in mice.{16615}
Brand:CaymanSKU:10011032 - 25 mgAvailable on backorder
QX-314 is a membrane-impermeant lidocaine derivative that selectively blocks sodium channels on nociceptive neurons when delivered intracellularly via the TRPV1 channel, but is reportedly ineffective with extracellular application.{15625} When supplied in combination with 1 µM capsaicin, a TRPV1 receptor agonist, 5 mM QX-314 blocks 98% of sodium current in voltage-clamped nociceptive DRG neurons.{15625} QX-314 elicits a long-lasting decrease in the response to painful mechanical and thermal stimuli without imparting the motor deficits (e.g., numbness, paralysis) associated with many conventional local anesthetics.{15625} At concentrations ranging from 10-70 mM, peripheral application of QX-314 dose-dependently produces robust local anesthesia with slow onset in the guinea pig intradermal wheal assay, the murine tail-flick test, and the murine sciatic nerve blockade model.{16613} However, injection of 0.5-30 mM QX-314 in the lumbar intrathecal space produces neurotoxicity and death in mice.{16615}
Brand:CaymanSKU:10011032 - 50 mgAvailable on backorder
QX-77 is an activator of chaperone-mediated autophagy (CMA).{48935} It decreases mouse embryonic fibroblast (MEF) and Neuro2a cell death induced by paraquat or oleic acid (Item Nos. 90260 | 24659). QX-77 (20 µM) rescues defective trafficking and lysosomal localization of the CMA receptor LAMP2A in Ctns-/- MEFs and CTNS knockout human proximal tubule cells, models of the lysosomal storage disorder cystinosis.{48936}
Brand:CaymanSKU:29903 - 10 mgAvailable on backorder
QX-77 is an activator of chaperone-mediated autophagy (CMA).{48935} It decreases mouse embryonic fibroblast (MEF) and Neuro2a cell death induced by paraquat or oleic acid (Item Nos. 90260 | 24659). QX-77 (20 µM) rescues defective trafficking and lysosomal localization of the CMA receptor LAMP2A in Ctns-/- MEFs and CTNS knockout human proximal tubule cells, models of the lysosomal storage disorder cystinosis.{48936}
Brand:CaymanSKU:29903 - 25 mgAvailable on backorder
QX-77 is an activator of chaperone-mediated autophagy (CMA).{48935} It decreases mouse embryonic fibroblast (MEF) and Neuro2a cell death induced by paraquat or oleic acid (Item Nos. 90260 | 24659). QX-77 (20 µM) rescues defective trafficking and lysosomal localization of the CMA receptor LAMP2A in Ctns-/- MEFs and CTNS knockout human proximal tubule cells, models of the lysosomal storage disorder cystinosis.{48936}
Brand:CaymanSKU:29903 - 5 mgAvailable on backorder
QX-77 is an activator of chaperone-mediated autophagy (CMA).{48935} It decreases mouse embryonic fibroblast (MEF) and Neuro2a cell death induced by paraquat or oleic acid (Item Nos. 90260 | 24659). QX-77 (20 µM) rescues defective trafficking and lysosomal localization of the CMA receptor LAMP2A in Ctns-/- MEFs and CTNS knockout human proximal tubule cells, models of the lysosomal storage disorder cystinosis.{48936}
Brand:CaymanSKU:29903 - 50 mgAvailable on backorder
R 1530 is a multi-kinase inhibitor that targets over 20 kinases, including angiogenesis-related receptor tyrosine kinases (Kds = 61, 88, and 15 nM for FGFR1, PDGFRβ, and VEGFR2, respectively).{33271} It also inhibits FLT1, KIT, PLK4, and RET with Kd values of 9, 26, 11, and 22 nM, respectively.{33271} In cells, R 1530 delays mitosis, induces polyploidy, and blocks angiogenesis, ultimately promoting apoptosis or senescence.{33271,33272} R 1530 strongly inhibits human tumor cell proliferation and reduces the growth of tumors in cancer xenograft models.{33270}
Brand:CaymanSKU:- R 1530 is a multi-kinase inhibitor that targets over 20 kinases, including angiogenesis-related receptor tyrosine kinases (Kds = 61, 88, and 15 nM for FGFR1, PDGFRβ, and VEGFR2, respectively).{33271} It also inhibits FLT1, KIT, PLK4, and RET with Kd values of 9, 26, 11, and 22 nM, respectively.{33271} In cells, R 1530 delays mitosis, induces polyploidy, and blocks angiogenesis, ultimately promoting apoptosis or senescence.{33271,33272} R 1530 strongly inhibits human tumor cell proliferation and reduces the growth of tumors in cancer xenograft models.{33270}
Brand:CaymanSKU:- R 1530 is a multi-kinase inhibitor that targets over 20 kinases, including angiogenesis-related receptor tyrosine kinases (Kds = 61, 88, and 15 nM for FGFR1, PDGFRβ, and VEGFR2, respectively).{33271} It also inhibits FLT1, KIT, PLK4, and RET with Kd values of 9, 26, 11, and 22 nM, respectively.{33271} In cells, R 1530 delays mitosis, induces polyploidy, and blocks angiogenesis, ultimately promoting apoptosis or senescence.{33271,33272} R 1530 strongly inhibits human tumor cell proliferation and reduces the growth of tumors in cancer xenograft models.{33270}
Brand:CaymanSKU:- R 1530 is a multi-kinase inhibitor that targets over 20 kinases, including angiogenesis-related receptor tyrosine kinases (Kds = 61, 88, and 15 nM for FGFR1, PDGFRβ, and VEGFR2, respectively).{33271} It also inhibits FLT1, KIT, PLK4, and RET with Kd values of 9, 26, 11, and 22 nM, respectively.{33271} In cells, R 1530 delays mitosis, induces polyploidy, and blocks angiogenesis, ultimately promoting apoptosis or senescence.{33271,33272} R 1530 strongly inhibits human tumor cell proliferation and reduces the growth of tumors in cancer xenograft models.{33270}
Brand:CaymanSKU:-
Brand:CaymanSKU:10007128 - 100 gAvailable on backorder
Brand:CaymanSKU:10007128 - 25 gAvailable on backorder
Brand:CaymanSKU:10007128 - 250 gAvailable on backorder
Brand:CaymanSKU:- Brand:CaymanSKU:10007128 - 50 gAvailable on backorder
R-(-)-Phenylephrine is an adrenergic α1A receptor agonist (Ki = 1.4 µM) that demonstrates selectivity against the α1B and α1C receptor subtypes (Kis = 23.9 and 47.8 µM, respectively).{28120} By stimulating adrenergic α1 receptors, L-phenylephrine can induce aortic smooth muscle contractions, although reported relative affinity and potency values in rabbit are 5-fold weaker compared to that of L-norepinephrine (Item No. 16673).{28119} This compound is frequently used to precontract smooth muscle in preparations designed to study the properties of various vasodilator agents.{28121,28122}
Brand:CaymanSKU:-Available on backorder
R-(-)-Phenylephrine is an adrenergic α1A receptor agonist (Ki = 1.4 µM) that demonstrates selectivity against the α1B and α1C receptor subtypes (Kis = 23.9 and 47.8 µM, respectively).{28120} By stimulating adrenergic α1 receptors, L-phenylephrine can induce aortic smooth muscle contractions, although reported relative affinity and potency values in rabbit are 5-fold weaker compared to that of L-norepinephrine (Item No. 16673).{28119} This compound is frequently used to precontract smooth muscle in preparations designed to study the properties of various vasodilator agents.{28121,28122}
Brand:CaymanSKU:-Available on backorder
R-(-)-Phenylephrine is an adrenergic α1A receptor agonist (Ki = 1.4 µM) that demonstrates selectivity against the α1B and α1C receptor subtypes (Kis = 23.9 and 47.8 µM, respectively).{28120} By stimulating adrenergic α1 receptors, L-phenylephrine can induce aortic smooth muscle contractions, although reported relative affinity and potency values in rabbit are 5-fold weaker compared to that of L-norepinephrine (Item No. 16673).{28119} This compound is frequently used to precontract smooth muscle in preparations designed to study the properties of various vasodilator agents.{28121,28122}
Brand:CaymanSKU:-Available on backorder
R-(-)-Phenylephrine is an adrenergic α1A receptor agonist (Ki = 1.4 µM) that demonstrates selectivity against the α1B and α1C receptor subtypes (Kis = 23.9 and 47.8 µM, respectively).{28120} By stimulating adrenergic α1 receptors, L-phenylephrine can induce aortic smooth muscle contractions, although reported relative affinity and potency values in rabbit are 5-fold weaker compared to that of L-norepinephrine (Item No. 16673).{28119} This compound is frequently used to precontract smooth muscle in preparations designed to study the properties of various vasodilator agents.{28121,28122}
Brand:CaymanSKU:-Available on backorder
R-(–)-Flecainide is the (R) enantiomer of the antiarrhythmic agent flecainide (Item No. 20388).{48069} R-(–)-Flecainide prevents chloroform-induced ventricular fibrillation in mice (ED50 = 14.5 mg/kg). It also prevents ouabain-induced ectopic ventricular tachycardia in anesthetized dogs.
Brand:CaymanSKU:20682 -Available on backorder
R-(–)-Flecainide is the (R) enantiomer of the antiarrhythmic agent flecainide (Item No. 20388).{48069} R-(–)-Flecainide prevents chloroform-induced ventricular fibrillation in mice (ED50 = 14.5 mg/kg). It also prevents ouabain-induced ectopic ventricular tachycardia in anesthetized dogs.
Brand:CaymanSKU:20682 -Available on backorder
Monoamine oxidase (MAO) inhibitors have utility in ameliorating a variety of neurological conditions, including depression.{23885} R-(−)-Deprenyl is a selective, reversible inhibitor of MAO-B (Ki = 0.091 μM) over MAO-A (Ki = 9.06 μM).{23886,23884} In addition to finding use against depression, R-(−)-deprenyl provides neuroprotection which may be relevant to Parkinson’s disease, Alzheimer’s disease, Huntington’s disease, and stroke.{15160,23885} The ability of this compound to slow the progression of disability in early Parkinson’s disease may be independent of its effects on MAO activity.{15160}
Brand:CaymanSKU:- Monoamine oxidase (MAO) inhibitors have utility in ameliorating a variety of neurological conditions, including depression.{23885} R-(−)-Deprenyl is a selective, reversible inhibitor of MAO-B (Ki = 0.091 μM) over MAO-A (Ki = 9.06 μM).{23886,23884} In addition to finding use against depression, R-(−)-deprenyl provides neuroprotection which may be relevant to Parkinson’s disease, Alzheimer’s disease, Huntington’s disease, and stroke.{15160,23885} The ability of this compound to slow the progression of disability in early Parkinson’s disease may be independent of its effects on MAO activity.{15160}
Brand:CaymanSKU:- Monoamine oxidase (MAO) inhibitors have utility in ameliorating a variety of neurological conditions, including depression.{23885} R-(−)-Deprenyl is a selective, reversible inhibitor of MAO-B (Ki = 0.091 μM) over MAO-A (Ki = 9.06 μM).{23886,23884} In addition to finding use against depression, R-(−)-deprenyl provides neuroprotection which may be relevant to Parkinson’s disease, Alzheimer’s disease, Huntington’s disease, and stroke.{15160,23885} The ability of this compound to slow the progression of disability in early Parkinson’s disease may be independent of its effects on MAO activity.{15160}
Brand:CaymanSKU:- Monoamine oxidase (MAO) inhibitors have utility in ameliorating a variety of neurological conditions, including depression.{23885} R-(−)-Deprenyl is a selective, reversible inhibitor of MAO-B (Ki = 0.091 μM) over MAO-A (Ki = 9.06 μM).{23886,23884} In addition to finding use against depression, R-(−)-deprenyl provides neuroprotection which may be relevant to Parkinson’s disease, Alzheimer’s disease, Huntington’s disease, and stroke.{15160,23885} The ability of this compound to slow the progression of disability in early Parkinson’s disease may be independent of its effects on MAO activity.{15160}
Brand:CaymanSKU:-
R-(−)-α-Methylhistamine is a histamine H3 receptor agonist with diverse biological activities.{43474} It inhibits the release of histamine induced by antidromic electrical stimulation of the sciatic nerve in rats when administered at doses ranging from 0.25 to 2 mg/kg, an effect that can be reversed by the selective histamine H3 receptor antagonist thioperamide (Item No. 10011127). R-(−)-α-Methylhistamine (0.5-50 nmol) inhibits gastric acid secretion in rats when administered intracerebroventricularly but not intravenously.{43475} It reduces isolation-induced vocalizations and aggressive behavior in a resident-intruder test in guinea pig pups and mice, respectively.{43476} R-(−)-α-Methylhistamine (30 mg/kg) decreases freezing time in a conditioned fear stress test in rats. It also acts synergistically with fentanyl to reduce nociception and plasma extravasation in a mouse model of chronic inflammation induced by complete Freund’s adjuvant.{43477}
Brand:CaymanSKU:25601 - 1 mgAvailable on backorder
R-(−)-α-Methylhistamine is a histamine H3 receptor agonist with diverse biological activities.{43474} It inhibits the release of histamine induced by antidromic electrical stimulation of the sciatic nerve in rats when administered at doses ranging from 0.25 to 2 mg/kg, an effect that can be reversed by the selective histamine H3 receptor antagonist thioperamide (Item No. 10011127). R-(−)-α-Methylhistamine (0.5-50 nmol) inhibits gastric acid secretion in rats when administered intracerebroventricularly but not intravenously.{43475} It reduces isolation-induced vocalizations and aggressive behavior in a resident-intruder test in guinea pig pups and mice, respectively.{43476} R-(−)-α-Methylhistamine (30 mg/kg) decreases freezing time in a conditioned fear stress test in rats. It also acts synergistically with fentanyl to reduce nociception and plasma extravasation in a mouse model of chronic inflammation induced by complete Freund’s adjuvant.{43477}
Brand:CaymanSKU:25601 - 10 mgAvailable on backorder
R-(−)-α-Methylhistamine is a histamine H3 receptor agonist with diverse biological activities.{43474} It inhibits the release of histamine induced by antidromic electrical stimulation of the sciatic nerve in rats when administered at doses ranging from 0.25 to 2 mg/kg, an effect that can be reversed by the selective histamine H3 receptor antagonist thioperamide (Item No. 10011127). R-(−)-α-Methylhistamine (0.5-50 nmol) inhibits gastric acid secretion in rats when administered intracerebroventricularly but not intravenously.{43475} It reduces isolation-induced vocalizations and aggressive behavior in a resident-intruder test in guinea pig pups and mice, respectively.{43476} R-(−)-α-Methylhistamine (30 mg/kg) decreases freezing time in a conditioned fear stress test in rats. It also acts synergistically with fentanyl to reduce nociception and plasma extravasation in a mouse model of chronic inflammation induced by complete Freund’s adjuvant.{43477}
Brand:CaymanSKU:25601 - 25 mgAvailable on backorder
R-(−)-α-Methylhistamine is a histamine H3 receptor agonist with diverse biological activities.{43474} It inhibits the release of histamine induced by antidromic electrical stimulation of the sciatic nerve in rats when administered at doses ranging from 0.25 to 2 mg/kg, an effect that can be reversed by the selective histamine H3 receptor antagonist thioperamide (Item No. 10011127). R-(−)-α-Methylhistamine (0.5-50 nmol) inhibits gastric acid secretion in rats when administered intracerebroventricularly but not intravenously.{43475} It reduces isolation-induced vocalizations and aggressive behavior in a resident-intruder test in guinea pig pups and mice, respectively.{43476} R-(−)-α-Methylhistamine (30 mg/kg) decreases freezing time in a conditioned fear stress test in rats. It also acts synergistically with fentanyl to reduce nociception and plasma extravasation in a mouse model of chronic inflammation induced by complete Freund’s adjuvant.{43477}
Brand:CaymanSKU:25601 - 5 mgAvailable on backorder
R-1 methanandamide is a potent cannabinoid (CB) receptor 1 agonist in the methanandamide series. It is selective for CB1 over CB2 receptors with Ki values ranging from 17.9 to 28.3 and 815 to 868 nM, respectively.{7912, 10685} R-1 methanandamide is more potent than arachidonoyl ethanolamide (AEA; Item No. 90050). In addition, R-1 methanandamide is more resistant than AEA to hydrolytic inactivation by fatty acid amide hydrolase (FAAH).{1092}
Brand:CaymanSKU:90070 - 10 mgAvailable on backorder
R-1 methanandamide is a potent cannabinoid (CB) receptor 1 agonist in the methanandamide series. It is selective for CB1 over CB2 receptors with Ki values ranging from 17.9 to 28.3 and 815 to 868 nM, respectively.{7912, 10685} R-1 methanandamide is more potent than arachidonoyl ethanolamide (AEA; Item No. 90050). In addition, R-1 methanandamide is more resistant than AEA to hydrolytic inactivation by fatty acid amide hydrolase (FAAH).{1092}
Brand:CaymanSKU:90070 - 25 mgAvailable on backorder
R-1 methanandamide is a potent cannabinoid (CB) receptor 1 agonist in the methanandamide series. It is selective for CB1 over CB2 receptors with Ki values ranging from 17.9 to 28.3 and 815 to 868 nM, respectively.{7912, 10685} R-1 methanandamide is more potent than arachidonoyl ethanolamide (AEA; Item No. 90050). In addition, R-1 methanandamide is more resistant than AEA to hydrolytic inactivation by fatty acid amide hydrolase (FAAH).{1092}
Brand:CaymanSKU:90070 - 5 mgAvailable on backorder
R-1 methanandamide is a potent cannabinoid (CB) receptor 1 agonist in the methanandamide series. It is selective for CB1 over CB2 receptors with Ki values ranging from 17.9 to 28.3 and 815 to 868 nM, respectively.{7912, 10685} R-1 methanandamide is more potent than arachidonoyl ethanolamide (AEA; Item No. 90050). In addition, R-1 methanandamide is more resistant than AEA to hydrolytic inactivation by fatty acid amide hydrolase (FAAH).{1092}
Brand:CaymanSKU:90070 - 50 mgAvailable on backorder
Arachidonoyl ethanolamide (AEA) was the first endogenous cannabinoid (CB) to be isolated and characterized as an agonist acting on the same receptors (CB1 and CB2) as Δ9-THC.{1134,2713} Since that time, a number of related endocannabinoids have been isolated, most notably 2-arachidonoyl glycerol (2-AG).{2713} The phosphate ester of R-1 methanandamide, R-1MAP, has been tested as a water soluble prodrug analog of AEA.{11520} The activity of R-1MAP was essentially equivalent to that of AEA in the growth inhibition of C6 glioma cells. However, when tested for inhibition of AEA binding to isolated rat brain CB1 receptors, arachidonoyl ethanolamide phosphate (AEA-P) is about 5-fold less potent as an agonist with a Ki of about 200 nM.{9580} The phosphate esters of AEA and its analogs are also structural variants of lysophosphatidic acid (LPA). However, the effects of R-1MAP on the various LPA receptors have not been tested.
Brand:CaymanSKU:10004281 - 1 mgAvailable on backorder
Arachidonoyl ethanolamide (AEA) was the first endogenous cannabinoid (CB) to be isolated and characterized as an agonist acting on the same receptors (CB1 and CB2) as Δ9-THC.{1134,2713} Since that time, a number of related endocannabinoids have been isolated, most notably 2-arachidonoyl glycerol (2-AG).{2713} The phosphate ester of R-1 methanandamide, R-1MAP, has been tested as a water soluble prodrug analog of AEA.{11520} The activity of R-1MAP was essentially equivalent to that of AEA in the growth inhibition of C6 glioma cells. However, when tested for inhibition of AEA binding to isolated rat brain CB1 receptors, arachidonoyl ethanolamide phosphate (AEA-P) is about 5-fold less potent as an agonist with a Ki of about 200 nM.{9580} The phosphate esters of AEA and its analogs are also structural variants of lysophosphatidic acid (LPA). However, the effects of R-1MAP on the various LPA receptors have not been tested.
Brand:CaymanSKU:10004281 - 10 mgAvailable on backorder