Cayman
Showing 36751–36900 of 45550 results
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PTP Inhibitor I is a cell-permeable, protein tyrosine phosphatase (PTP) inhibitor that covalently blocks the catalytic domain of the Src homology region 2 domain-containing phosphatase (SHP-1(ΔSH2)) with a Ki value of 43 µM and PTP1B with a Ki value of 42 µM.{31401} SHP-1 and PTP1B both have known roles in regulating insulin signaling as well as myeloid and lymphoid cell differentiation, making inhibitors of these phosphatases of interest in diabetes, cancer, allergy, and inflammation research.{31658}
Brand:CaymanSKU:19766 -Available on backorder
PTP inhibitor II is a cell-permeable protein tyrosine phosphatase (PTP) inhibitor that covalently binds the catalytic domain of the Src homology region 2 domain-containing phosphatase (SHP-1(ΔSH2)).{31401} PTP inhibitor II binds with lower affinity than PTP Inhibitor I (Item No. 19766) with Ki values of 128 and 43 μM, respectively.{31401} SHP-1 has known roles in regulating insulin signaling as well as myeloid and lymphoid cell differentiation, making inhibitors of these phosphatases of interest in diabetes, cancer, allergy, and inflammation research.{31658}
Brand:CaymanSKU:20629 -Available on backorder
PTP inhibitor II is a cell-permeable protein tyrosine phosphatase (PTP) inhibitor that covalently binds the catalytic domain of the Src homology region 2 domain-containing phosphatase (SHP-1(ΔSH2)).{31401} PTP inhibitor II binds with lower affinity than PTP Inhibitor I (Item No. 19766) with Ki values of 128 and 43 μM, respectively.{31401} SHP-1 has known roles in regulating insulin signaling as well as myeloid and lymphoid cell differentiation, making inhibitors of these phosphatases of interest in diabetes, cancer, allergy, and inflammation research.{31658}
Brand:CaymanSKU:20629 -Available on backorder
PTP inhibitor II is a cell-permeable protein tyrosine phosphatase (PTP) inhibitor that covalently binds the catalytic domain of the Src homology region 2 domain-containing phosphatase (SHP-1(ΔSH2)).{31401} PTP inhibitor II binds with lower affinity than PTP Inhibitor I (Item No. 19766) with Ki values of 128 and 43 μM, respectively.{31401} SHP-1 has known roles in regulating insulin signaling as well as myeloid and lymphoid cell differentiation, making inhibitors of these phosphatases of interest in diabetes, cancer, allergy, and inflammation research.{31658}
Brand:CaymanSKU:20629 -Available on backorder
PTP inhibitor II is a cell-permeable protein tyrosine phosphatase (PTP) inhibitor that covalently binds the catalytic domain of the Src homology region 2 domain-containing phosphatase (SHP-1(ΔSH2)).{31401} PTP inhibitor II binds with lower affinity than PTP Inhibitor I (Item No. 19766) with Ki values of 128 and 43 μM, respectively.{31401} SHP-1 has known roles in regulating insulin signaling as well as myeloid and lymphoid cell differentiation, making inhibitors of these phosphatases of interest in diabetes, cancer, allergy, and inflammation research.{31658}
Brand:CaymanSKU:20629 -Available on backorder
PTP Inhibitor III is an α-haloacetophenone derivative that acts as a photoreversible covalent inhibitor of protein tyrosine phosphatases (PTPs).{31401} It binds the catalytic domain of SHP-1 (Ki = 184 µM) and covalently reacts with free thiols, a reaction that is reversible with irradiation (350 nm). PTP Inhibitor III is cell permeable and inhibits a broad range of PTPs.{31402}
Brand:CaymanSKU:-Available on backorder
PTP Inhibitor III is an α-haloacetophenone derivative that acts as a photoreversible covalent inhibitor of protein tyrosine phosphatases (PTPs).{31401} It binds the catalytic domain of SHP-1 (Ki = 184 µM) and covalently reacts with free thiols, a reaction that is reversible with irradiation (350 nm). PTP Inhibitor III is cell permeable and inhibits a broad range of PTPs.{31402}
Brand:CaymanSKU:-Available on backorder
PTP Inhibitor III is an α-haloacetophenone derivative that acts as a photoreversible covalent inhibitor of protein tyrosine phosphatases (PTPs).{31401} It binds the catalytic domain of SHP-1 (Ki = 184 µM) and covalently reacts with free thiols, a reaction that is reversible with irradiation (350 nm). PTP Inhibitor III is cell permeable and inhibits a broad range of PTPs.{31402}
Brand:CaymanSKU:-Available on backorder
Protein tyrosine phosphatases (PTPs) remove phosphate from tyrosine residues of cellular proteins. Reversible phosphorylation catalyzed by the coordinated actions of protein tyrosine kinases and phosphatases is key to the regulation of the signaling events that control cell growth and proliferation, differentiation, and survival or apoptosis, as well as adhesion and motility. PTP inhibitor IV is an uncharged, 1,4-di-substituted, phenyl-linked bis-trifluoromethylsulfonamido phosphate mimetic that acts as a reversible, competitive, and active-site directed inhibitor of SHP-2, PTP1B, PTP-ε, PTP-Meg-2, PTP-σ, PTP-β, and PTP-µ (IC50s = 1.8, 2.5, 8.4, 13, 20, 6.4, and 6.7 µM, respectively).{29689}
Brand:CaymanSKU:-Available on backorder
Protein tyrosine phosphatases (PTPs) remove phosphate from tyrosine residues of cellular proteins. Reversible phosphorylation catalyzed by the coordinated actions of protein tyrosine kinases and phosphatases is key to the regulation of the signaling events that control cell growth and proliferation, differentiation, and survival or apoptosis, as well as adhesion and motility. PTP inhibitor IV is an uncharged, 1,4-di-substituted, phenyl-linked bis-trifluoromethylsulfonamido phosphate mimetic that acts as a reversible, competitive, and active-site directed inhibitor of SHP-2, PTP1B, PTP-ε, PTP-Meg-2, PTP-σ, PTP-β, and PTP-µ (IC50s = 1.8, 2.5, 8.4, 13, 20, 6.4, and 6.7 µM, respectively).{29689}
Brand:CaymanSKU:-Available on backorder
Protein tyrosine phosphatases (PTPs) remove phosphate from tyrosine residues of cellular proteins. Reversible phosphorylation catalyzed by the coordinated actions of protein tyrosine kinases and phosphatases is key to the regulation of the signaling events that control cell growth and proliferation, differentiation, and survival or apoptosis, as well as adhesion and motility. PTP inhibitor IV is an uncharged, 1,4-di-substituted, phenyl-linked bis-trifluoromethylsulfonamido phosphate mimetic that acts as a reversible, competitive, and active-site directed inhibitor of SHP-2, PTP1B, PTP-ε, PTP-Meg-2, PTP-σ, PTP-β, and PTP-µ (IC50s = 1.8, 2.5, 8.4, 13, 20, 6.4, and 6.7 µM, respectively).{29689}
Brand:CaymanSKU:-Available on backorder
Protein tyrosine phosphatases (PTPs) remove phosphate from tyrosine residues of cellular proteins. Reversible phosphorylation catalyzed by the coordinated actions of protein tyrosine kinases and phosphatases is key to the regulation of the signaling events that control cell growth and proliferation, differentiation, and survival or apoptosis, as well as adhesion and motility. PTP inhibitor IV is an uncharged, 1,4-di-substituted, phenyl-linked bis-trifluoromethylsulfonamido phosphate mimetic that acts as a reversible, competitive, and active-site directed inhibitor of SHP-2, PTP1B, PTP-ε, PTP-Meg-2, PTP-σ, PTP-β, and PTP-µ (IC50s = 1.8, 2.5, 8.4, 13, 20, 6.4, and 6.7 µM, respectively).{29689}
Brand:CaymanSKU:-Available on backorder
Protein tyrosine phosphatase 1B (PTP1B) has critical roles in cell signaling relevant to diabetes, obesity, and cancer.{15396,26227} PTP1B inhibitor is a cell-permeable allosteric inhibitor of PTP1B (IC50s = 4 and 8 µM for 403 and 298 residue PTP1B forms, respectively).{26228} It binds reversibly and non-competitively, altering the conformation of the catalytic pocket.{26228,26226} PTP1B inhibitor selectively increases the phosphorylation of the insulin receptor, insulin receptor substrate 1, and Akt, mimicking the action of insulin.{26228}
Brand:CaymanSKU:- Protein tyrosine phosphatase 1B (PTP1B) has critical roles in cell signaling relevant to diabetes, obesity, and cancer.{15396,26227} PTP1B inhibitor is a cell-permeable allosteric inhibitor of PTP1B (IC50s = 4 and 8 µM for 403 and 298 residue PTP1B forms, respectively).{26228} It binds reversibly and non-competitively, altering the conformation of the catalytic pocket.{26228,26226} PTP1B inhibitor selectively increases the phosphorylation of the insulin receptor, insulin receptor substrate 1, and Akt, mimicking the action of insulin.{26228}
Brand:CaymanSKU:- Protein tyrosine phosphatase 1B (PTP1B) has critical roles in cell signaling relevant to diabetes, obesity, and cancer.{15396,26227} PTP1B inhibitor is a cell-permeable allosteric inhibitor of PTP1B (IC50s = 4 and 8 µM for 403 and 298 residue PTP1B forms, respectively).{26228} It binds reversibly and non-competitively, altering the conformation of the catalytic pocket.{26228,26226} PTP1B inhibitor selectively increases the phosphorylation of the insulin receptor, insulin receptor substrate 1, and Akt, mimicking the action of insulin.{26228}
Brand:CaymanSKU:- Protein tyrosine phosphatase 1B (PTP1B) has critical roles in cell signaling relevant to diabetes, obesity, and cancer.{15396,26227} PTP1B inhibitor is a cell-permeable allosteric inhibitor of PTP1B (IC50s = 4 and 8 µM for 403 and 298 residue PTP1B forms, respectively).{26228} It binds reversibly and non-competitively, altering the conformation of the catalytic pocket.{26228,26226} PTP1B inhibitor selectively increases the phosphorylation of the insulin receptor, insulin receptor substrate 1, and Akt, mimicking the action of insulin.{26228}
Brand:CaymanSKU:-
PTZ-343 is a water-soluble enhancer of luminol (Item No. 16803) chemiluminescent peroxidation catalyzed by horseradish peroxidase (HRP).{40227} It acts as an electron transfer mediator, reacting with HRP-II to release HRP and a PTZ-343 radical, which oxidizes luminol anions to induce light emission. HRP-induced chemiluminescent light emission increases by >800% in the presence of PTZ-343. It also enhances soybean peroxidase-induced chemiluminescence, increasing sensitivity and lowering the detection limit from 1.1 to 0.18 pM.{40228}
Brand:CaymanSKU:22908 - 100 mgAvailable on backorder
PTZ-343 is a water-soluble enhancer of luminol (Item No. 16803) chemiluminescent peroxidation catalyzed by horseradish peroxidase (HRP).{40227} It acts as an electron transfer mediator, reacting with HRP-II to release HRP and a PTZ-343 radical, which oxidizes luminol anions to induce light emission. HRP-induced chemiluminescent light emission increases by >800% in the presence of PTZ-343. It also enhances soybean peroxidase-induced chemiluminescence, increasing sensitivity and lowering the detection limit from 1.1 to 0.18 pM.{40228}
Brand:CaymanSKU:22908 - 250 mgAvailable on backorder
PTZ-343 is a water-soluble enhancer of luminol (Item No. 16803) chemiluminescent peroxidation catalyzed by horseradish peroxidase (HRP).{40227} It acts as an electron transfer mediator, reacting with HRP-II to release HRP and a PTZ-343 radical, which oxidizes luminol anions to induce light emission. HRP-induced chemiluminescent light emission increases by >800% in the presence of PTZ-343. It also enhances soybean peroxidase-induced chemiluminescence, increasing sensitivity and lowering the detection limit from 1.1 to 0.18 pM.{40228}
Brand:CaymanSKU:22908 - 50 mgAvailable on backorder
PTZ-343 is a water-soluble enhancer of luminol (Item No. 16803) chemiluminescent peroxidation catalyzed by horseradish peroxidase (HRP).{40227} It acts as an electron transfer mediator, reacting with HRP-II to release HRP and a PTZ-343 radical, which oxidizes luminol anions to induce light emission. HRP-induced chemiluminescent light emission increases by >800% in the presence of PTZ-343. It also enhances soybean peroxidase-induced chemiluminescence, increasing sensitivity and lowering the detection limit from 1.1 to 0.18 pM.{40228}
Brand:CaymanSKU:22908 - 500 mgAvailable on backorder
PU 02 is an antagonist of the serotonin (5-HT) receptor subtype 5-HT3 with IC50 values ranging from 0.36 to 1.3 μM for human 5-HT3A, 5-HT3AB, 5-HT3AC, and 5-HT3AE in a FLIPR membrane potential assay using HEK293 cells expressing human recombinant receptors.{38330} It is selective for 5-HT3 over other Cys-loop containing receptors with IC50 values >100 μM for mouse, rat, and human nicotinic (nACh), human GABAA, and human glycine (Gly) receptors. PU 02 inhibits currents induced by 5-HT (Item No. 14332) in COS-7 cells expressing human 5-HT3A (IC50 = 0.49 μM). PU 02 also reduces growth of HepG2 cells in a dose-dependent manner via induction of cell cycle arrest at the G2/M phase and apoptosis.{38329}
Brand:CaymanSKU:- PU 02 is an antagonist of the serotonin (5-HT) receptor subtype 5-HT3 with IC50 values ranging from 0.36 to 1.3 μM for human 5-HT3A, 5-HT3AB, 5-HT3AC, and 5-HT3AE in a FLIPR membrane potential assay using HEK293 cells expressing human recombinant receptors.{38330} It is selective for 5-HT3 over other Cys-loop containing receptors with IC50 values >100 μM for mouse, rat, and human nicotinic (nACh), human GABAA, and human glycine (Gly) receptors. PU 02 inhibits currents induced by 5-HT (Item No. 14332) in COS-7 cells expressing human 5-HT3A (IC50 = 0.49 μM). PU 02 also reduces growth of HepG2 cells in a dose-dependent manner via induction of cell cycle arrest at the G2/M phase and apoptosis.{38329}
Brand:CaymanSKU:- PU 02 is an antagonist of the serotonin (5-HT) receptor subtype 5-HT3 with IC50 values ranging from 0.36 to 1.3 μM for human 5-HT3A, 5-HT3AB, 5-HT3AC, and 5-HT3AE in a FLIPR membrane potential assay using HEK293 cells expressing human recombinant receptors.{38330} It is selective for 5-HT3 over other Cys-loop containing receptors with IC50 values >100 μM for mouse, rat, and human nicotinic (nACh), human GABAA, and human glycine (Gly) receptors. PU 02 inhibits currents induced by 5-HT (Item No. 14332) in COS-7 cells expressing human 5-HT3A (IC50 = 0.49 μM). PU 02 also reduces growth of HepG2 cells in a dose-dependent manner via induction of cell cycle arrest at the G2/M phase and apoptosis.{38329}
Brand:CaymanSKU:- PU 02 is an antagonist of the serotonin (5-HT) receptor subtype 5-HT3 with IC50 values ranging from 0.36 to 1.3 μM for human 5-HT3A, 5-HT3AB, 5-HT3AC, and 5-HT3AE in a FLIPR membrane potential assay using HEK293 cells expressing human recombinant receptors.{38330} It is selective for 5-HT3 over other Cys-loop containing receptors with IC50 values >100 μM for mouse, rat, and human nicotinic (nACh), human GABAA, and human glycine (Gly) receptors. PU 02 inhibits currents induced by 5-HT (Item No. 14332) in COS-7 cells expressing human 5-HT3A (IC50 = 0.49 μM). PU 02 also reduces growth of HepG2 cells in a dose-dependent manner via induction of cell cycle arrest at the G2/M phase and apoptosis.{38329}
Brand:CaymanSKU:-
PU-WS13 is an inhibitor of the heat shock protein family member and chaperone protein glucose-regulated protein 94 (GRP94; IC50 = 0.22 µM).{54397} It is selective for GRP94 over the chaperones Hsp90α, Hsp90β, and TRAP1 (IC50s = 27.3, 41.8, and 7.3 µM, respectively). PU-WS13 (0.5, 2.5, and 12.5 µM) induces apoptosis without increasing Hsp70 protein levels in HER2-overexpressing SK-BR-3, BT474, and MDA-MB-361 breast cancer cells.{30011} It also induces apoptosis and necrosis in multiple myeloma cells but does not induces cell death in pre-B leukemic cells.{30009}
Brand:CaymanSKU:-Available on backorder
PU-WS13 is an inhibitor of the heat shock protein family member and chaperone protein glucose-regulated protein 94 (GRP94; IC50 = 0.22 µM).{54397} It is selective for GRP94 over the chaperones Hsp90α, Hsp90β, and TRAP1 (IC50s = 27.3, 41.8, and 7.3 µM, respectively). PU-WS13 (0.5, 2.5, and 12.5 µM) induces apoptosis without increasing Hsp70 protein levels in HER2-overexpressing SK-BR-3, BT474, and MDA-MB-361 breast cancer cells.{30011} It also induces apoptosis and necrosis in multiple myeloma cells but does not induces cell death in pre-B leukemic cells.{30009}
Brand:CaymanSKU:-Available on backorder
PU-WS13 is an inhibitor of the heat shock protein family member and chaperone protein glucose-regulated protein 94 (GRP94; IC50 = 0.22 µM).{54397} It is selective for GRP94 over the chaperones Hsp90α, Hsp90β, and TRAP1 (IC50s = 27.3, 41.8, and 7.3 µM, respectively). PU-WS13 (0.5, 2.5, and 12.5 µM) induces apoptosis without increasing Hsp70 protein levels in HER2-overexpressing SK-BR-3, BT474, and MDA-MB-361 breast cancer cells.{30011} It also induces apoptosis and necrosis in multiple myeloma cells but does not induces cell death in pre-B leukemic cells.{30009}
Brand:CaymanSKU:-Available on backorder
PU-WS13 is an inhibitor of the heat shock protein family member and chaperone protein glucose-regulated protein 94 (GRP94; IC50 = 0.22 µM).{54397} It is selective for GRP94 over the chaperones Hsp90α, Hsp90β, and TRAP1 (IC50s = 27.3, 41.8, and 7.3 µM, respectively). PU-WS13 (0.5, 2.5, and 12.5 µM) induces apoptosis without increasing Hsp70 protein levels in HER2-overexpressing SK-BR-3, BT474, and MDA-MB-361 breast cancer cells.{30011} It also induces apoptosis and necrosis in multiple myeloma cells but does not induces cell death in pre-B leukemic cells.{30009}
Brand:CaymanSKU:-Available on backorder
Puerarin is a natural isoflavone isolated from plants of the genus Pueraria used in traditional Chinese herbal medicine. It is biotransformed by intestinal bacteria to give the phytoestrogens daidzein (Item No. 10005166) and equol (Item No. 13184), resulting in antithrombotic, antiallergic, and other salutary effects.{22404,22407,22408} When given intraperitoneally, puerarin evokes diverse responses by modulating serotonin receptors.{22409,22405} This compound also suppresses lipopolysaccharide-mediated activation of NF-κB in RAW 264.6 macrophages when given at 20-40 μM.{22406}
Brand:CaymanSKU:- Puerarin is a natural isoflavone isolated from plants of the genus Pueraria used in traditional Chinese herbal medicine. It is biotransformed by intestinal bacteria to give the phytoestrogens daidzein (Item No. 10005166) and equol (Item No. 13184), resulting in antithrombotic, antiallergic, and other salutary effects.{22404,22407,22408} When given intraperitoneally, puerarin evokes diverse responses by modulating serotonin receptors.{22409,22405} This compound also suppresses lipopolysaccharide-mediated activation of NF-κB in RAW 264.6 macrophages when given at 20-40 μM.{22406}
Brand:CaymanSKU:- Puerarin is a natural isoflavone isolated from plants of the genus Pueraria used in traditional Chinese herbal medicine. It is biotransformed by intestinal bacteria to give the phytoestrogens daidzein (Item No. 10005166) and equol (Item No. 13184), resulting in antithrombotic, antiallergic, and other salutary effects.{22404,22407,22408} When given intraperitoneally, puerarin evokes diverse responses by modulating serotonin receptors.{22409,22405} This compound also suppresses lipopolysaccharide-mediated activation of NF-κB in RAW 264.6 macrophages when given at 20-40 μM.{22406}
Brand:CaymanSKU:- Puerarin is a natural isoflavone isolated from plants of the genus Pueraria used in traditional Chinese herbal medicine. It is biotransformed by intestinal bacteria to give the phytoestrogens daidzein (Item No. 10005166) and equol (Item No. 13184), resulting in antithrombotic, antiallergic, and other salutary effects.{22404,22407,22408} When given intraperitoneally, puerarin evokes diverse responses by modulating serotonin receptors.{22409,22405} This compound also suppresses lipopolysaccharide-mediated activation of NF-κB in RAW 264.6 macrophages when given at 20-40 μM.{22406}
Brand:CaymanSKU:-
Pulchinenoside A is a triterpenoid saponin that has been found in Pulsatilla chinensis and has diverse biological activities.{48595,48596} It inhibits NMDA-evoked currents in hippocampal neurons (IC50s = 18.48 and 20.19 μM at -50 and +50 mV, respectively) and inhibits NMDA-induced neuronal cell death when used at a concentration of 30 μM.{48596} Pulchinenoside A (30 and 100 mg/kg) increases the levels of serotonin (5-HT; Item No. 14332), 5-hydroxyindolacetic acid (5-HIAA; Item No. 22889), and norepinephrine (Item No. 16673) in the hippocampus and 5-HIAA and norepinephrine in the prefrontal cortex in mice. It reduces the time spent immobile in the forced swim test in mice when administered at doses of 30 and 100 mg/kg and increases the time spent in the target quadrant of the Morris water maze in mice at 100 mg/kg. Pulchinenoside A (12.6 and 25.2 mg/kg) reduces infarct volume in a middle cerebral artery occlusion (MCAO) rat model of ischemia. It also induces relaxation of precontracted isolated rat thoracic aorta and renal, mesenteric, and left coronary arteries in a concentration-dependent manner.{48595}
Brand:CaymanSKU:28545 - 10 mgAvailable on backorder
Pulchinenoside A is a triterpenoid saponin that has been found in Pulsatilla chinensis and has diverse biological activities.{48595,48596} It inhibits NMDA-evoked currents in hippocampal neurons (IC50s = 18.48 and 20.19 μM at -50 and +50 mV, respectively) and inhibits NMDA-induced neuronal cell death when used at a concentration of 30 μM.{48596} Pulchinenoside A (30 and 100 mg/kg) increases the levels of serotonin (5-HT; Item No. 14332), 5-hydroxyindolacetic acid (5-HIAA; Item No. 22889), and norepinephrine (Item No. 16673) in the hippocampus and 5-HIAA and norepinephrine in the prefrontal cortex in mice. It reduces the time spent immobile in the forced swim test in mice when administered at doses of 30 and 100 mg/kg and increases the time spent in the target quadrant of the Morris water maze in mice at 100 mg/kg. Pulchinenoside A (12.6 and 25.2 mg/kg) reduces infarct volume in a middle cerebral artery occlusion (MCAO) rat model of ischemia. It also induces relaxation of precontracted isolated rat thoracic aorta and renal, mesenteric, and left coronary arteries in a concentration-dependent manner.{48595}
Brand:CaymanSKU:28545 - 25 mgAvailable on backorder
Pulchinenoside A is a triterpenoid saponin that has been found in Pulsatilla chinensis and has diverse biological activities.{48595,48596} It inhibits NMDA-evoked currents in hippocampal neurons (IC50s = 18.48 and 20.19 μM at -50 and +50 mV, respectively) and inhibits NMDA-induced neuronal cell death when used at a concentration of 30 μM.{48596} Pulchinenoside A (30 and 100 mg/kg) increases the levels of serotonin (5-HT; Item No. 14332), 5-hydroxyindolacetic acid (5-HIAA; Item No. 22889), and norepinephrine (Item No. 16673) in the hippocampus and 5-HIAA and norepinephrine in the prefrontal cortex in mice. It reduces the time spent immobile in the forced swim test in mice when administered at doses of 30 and 100 mg/kg and increases the time spent in the target quadrant of the Morris water maze in mice at 100 mg/kg. Pulchinenoside A (12.6 and 25.2 mg/kg) reduces infarct volume in a middle cerebral artery occlusion (MCAO) rat model of ischemia. It also induces relaxation of precontracted isolated rat thoracic aorta and renal, mesenteric, and left coronary arteries in a concentration-dependent manner.{48595}
Brand:CaymanSKU:28545 - 5 mgAvailable on backorder
Pulchinenoside A is a triterpenoid saponin that has been found in Pulsatilla chinensis and has diverse biological activities.{48595,48596} It inhibits NMDA-evoked currents in hippocampal neurons (IC50s = 18.48 and 20.19 μM at -50 and +50 mV, respectively) and inhibits NMDA-induced neuronal cell death when used at a concentration of 30 μM.{48596} Pulchinenoside A (30 and 100 mg/kg) increases the levels of serotonin (5-HT; Item No. 14332), 5-hydroxyindolacetic acid (5-HIAA; Item No. 22889), and norepinephrine (Item No. 16673) in the hippocampus and 5-HIAA and norepinephrine in the prefrontal cortex in mice. It reduces the time spent immobile in the forced swim test in mice when administered at doses of 30 and 100 mg/kg and increases the time spent in the target quadrant of the Morris water maze in mice at 100 mg/kg. Pulchinenoside A (12.6 and 25.2 mg/kg) reduces infarct volume in a middle cerebral artery occlusion (MCAO) rat model of ischemia. It also induces relaxation of precontracted isolated rat thoracic aorta and renal, mesenteric, and left coronary arteries in a concentration-dependent manner.{48595}
Brand:CaymanSKU:28545 - 50 mgAvailable on backorder
Pulchinenoside B4 is a triterpenoid glycoside that has been found in P. chinensis and has diverse biological activities.{48998,48999} It inhibits cisplatin-induced apoptosis, increases in reactive oxygen species (ROS) production, and decreases in superoxide dismutase (SOD) and catalase activities in HEK293 cells when used at concentrations of 6 and 12 μM.{48998} Pulchinenoside B4 (50 and 100 mg/kg twice per day) prevents increases in plasma blood urea nitrogen (BUN) and creatinine levels, markers of kidney injury, in a mouse model of cisplatin-induced nephrotoxicity. It prevents xylene-induced ear edema in mice in a dose-dependent manner.{48999} Pulchinenoside B4 (50 mg/kg) inhibits LPS-induced increases in serum TNF-α, IL-6, and IL-1β levels a mouse model of LPS-induced systemic inflammation.
Brand:CaymanSKU:30271 - 10 mgAvailable on backorder
Pulchinenoside B4 is a triterpenoid glycoside that has been found in P. chinensis and has diverse biological activities.{48998,48999} It inhibits cisplatin-induced apoptosis, increases in reactive oxygen species (ROS) production, and decreases in superoxide dismutase (SOD) and catalase activities in HEK293 cells when used at concentrations of 6 and 12 μM.{48998} Pulchinenoside B4 (50 and 100 mg/kg twice per day) prevents increases in plasma blood urea nitrogen (BUN) and creatinine levels, markers of kidney injury, in a mouse model of cisplatin-induced nephrotoxicity. It prevents xylene-induced ear edema in mice in a dose-dependent manner.{48999} Pulchinenoside B4 (50 mg/kg) inhibits LPS-induced increases in serum TNF-α, IL-6, and IL-1β levels a mouse model of LPS-induced systemic inflammation.
Brand:CaymanSKU:30271 - 25 mgAvailable on backorder
Pulchinenoside B4 is a triterpenoid glycoside that has been found in P. chinensis and has diverse biological activities.{48998,48999} It inhibits cisplatin-induced apoptosis, increases in reactive oxygen species (ROS) production, and decreases in superoxide dismutase (SOD) and catalase activities in HEK293 cells when used at concentrations of 6 and 12 μM.{48998} Pulchinenoside B4 (50 and 100 mg/kg twice per day) prevents increases in plasma blood urea nitrogen (BUN) and creatinine levels, markers of kidney injury, in a mouse model of cisplatin-induced nephrotoxicity. It prevents xylene-induced ear edema in mice in a dose-dependent manner.{48999} Pulchinenoside B4 (50 mg/kg) inhibits LPS-induced increases in serum TNF-α, IL-6, and IL-1β levels a mouse model of LPS-induced systemic inflammation.
Brand:CaymanSKU:30271 - 5 mgAvailable on backorder
Pulchinenoside B4 is a triterpenoid glycoside that has been found in P. chinensis and has diverse biological activities.{48998,48999} It inhibits cisplatin-induced apoptosis, increases in reactive oxygen species (ROS) production, and decreases in superoxide dismutase (SOD) and catalase activities in HEK293 cells when used at concentrations of 6 and 12 μM.{48998} Pulchinenoside B4 (50 and 100 mg/kg twice per day) prevents increases in plasma blood urea nitrogen (BUN) and creatinine levels, markers of kidney injury, in a mouse model of cisplatin-induced nephrotoxicity. It prevents xylene-induced ear edema in mice in a dose-dependent manner.{48999} Pulchinenoside B4 (50 mg/kg) inhibits LPS-induced increases in serum TNF-α, IL-6, and IL-1β levels a mouse model of LPS-induced systemic inflammation.
Brand:CaymanSKU:30271 - 50 mgAvailable on backorder
Pulsatilla saponin D is an oleanane-type saponin that has been found in P. koreana and has anticancer activity.{52250} It is cytotoxic to A549, SKOV3, SK-MEL-2, and HCT15 cells (EC50s = 11.25, 13.17, 3.04, and 11.86 μM, respectively). Pulsatilla saponin D (6 mg/kg per day) reduces tumor volume in a murine Lewis lung carcinoma model.
Brand:CaymanSKU:29455 - 1 mgAvailable on backorder
Pulsatilla saponin D is an oleanane-type saponin that has been found in P. koreana and has anticancer activity.{52250} It is cytotoxic to A549, SKOV3, SK-MEL-2, and HCT15 cells (EC50s = 11.25, 13.17, 3.04, and 11.86 μM, respectively). Pulsatilla saponin D (6 mg/kg per day) reduces tumor volume in a murine Lewis lung carcinoma model.
Brand:CaymanSKU:29455 - 5 mgAvailable on backorder
Punicalagin is a major ellagitannin found in pomegranates that is reported to produce antioxidant, anti-inflammatory, and anticancer effects.{32662} It has been shown to prevent high-fat diet-induced obesity-associated accumulation of cardiac triglyceride and cholesterol, as well as myocardial damage, via AMPK-mediated modulation of mitochondria and phase II enzymes.{32661}
Brand:CaymanSKU:- Punicalagin is a major ellagitannin found in pomegranates that is reported to produce antioxidant, anti-inflammatory, and anticancer effects.{32662} It has been shown to prevent high-fat diet-induced obesity-associated accumulation of cardiac triglyceride and cholesterol, as well as myocardial damage, via AMPK-mediated modulation of mitochondria and phase II enzymes.{32661}
Brand:CaymanSKU:- Punicalagin is a major ellagitannin found in pomegranates that is reported to produce antioxidant, anti-inflammatory, and anticancer effects.{32662} It has been shown to prevent high-fat diet-induced obesity-associated accumulation of cardiac triglyceride and cholesterol, as well as myocardial damage, via AMPK-mediated modulation of mitochondria and phase II enzymes.{32661}
Brand:CaymanSKU:- Punicalagin is a major ellagitannin found in pomegranates that is reported to produce antioxidant, anti-inflammatory, and anticancer effects.{32662} It has been shown to prevent high-fat diet-induced obesity-associated accumulation of cardiac triglyceride and cholesterol, as well as myocardial damage, via AMPK-mediated modulation of mitochondria and phase II enzymes.{32661}
Brand:CaymanSKU:-
Purine is an aromatic heterocyclic organic compound. It is biosynthesized from amino acids and bicarbonate.{54328} Purine is the core structure of the nucleobases adenine (Item No. 18148) and guanine, the nucleosides adenosine (Item No. 21232) and guanosine (Item No. 27702), and the nucleotides, adenosine mono- (AMP; Item No. 21094), di- (ADP; Item No. 16778 | 21121), and triphosphate (ATP; Item No. 14498), and guanosine mono- (GMP; Item No. 16957), di-, and triphosphate (GTP; Item No. 16060).
Brand:CaymanSKU:30853 - 1 gAvailable on backorder
Purine is an aromatic heterocyclic organic compound. It is biosynthesized from amino acids and bicarbonate.{54328} Purine is the core structure of the nucleobases adenine (Item No. 18148) and guanine, the nucleosides adenosine (Item No. 21232) and guanosine (Item No. 27702), and the nucleotides, adenosine mono- (AMP; Item No. 21094), di- (ADP; Item No. 16778 | 21121), and triphosphate (ATP; Item No. 14498), and guanosine mono- (GMP; Item No. 16957), di-, and triphosphate (GTP; Item No. 16060).
Brand:CaymanSKU:30853 - 100 mgAvailable on backorder
Purine is an aromatic heterocyclic organic compound. It is biosynthesized from amino acids and bicarbonate.{54328} Purine is the core structure of the nucleobases adenine (Item No. 18148) and guanine, the nucleosides adenosine (Item No. 21232) and guanosine (Item No. 27702), and the nucleotides, adenosine mono- (AMP; Item No. 21094), di- (ADP; Item No. 16778 | 21121), and triphosphate (ATP; Item No. 14498), and guanosine mono- (GMP; Item No. 16957), di-, and triphosphate (GTP; Item No. 16060).
Brand:CaymanSKU:30853 - 250 mgAvailable on backorder
Purine is an aromatic heterocyclic organic compound. It is biosynthesized from amino acids and bicarbonate.{54328} Purine is the core structure of the nucleobases adenine (Item No. 18148) and guanine, the nucleosides adenosine (Item No. 21232) and guanosine (Item No. 27702), and the nucleotides, adenosine mono- (AMP; Item No. 21094), di- (ADP; Item No. 16778 | 21121), and triphosphate (ATP; Item No. 14498), and guanosine mono- (GMP; Item No. 16957), di-, and triphosphate (GTP; Item No. 16060).
Brand:CaymanSKU:30853 - 500 mgAvailable on backorder
Small molecules that promote osteoblast differentiation might be useful as therapeutic agents for bone diseases such as osteoporosis. Purmorphamine is a 2,6,9-trisubstituted purine that promotes the differentiation of both human and mouse mesenchymal progenitor cells into osteoblasts.{14871,14873} The EC50 value for differentiation of C3H10T1/2 cells based on alkaline phosphatase expression is 1 µM.{14871} Investigation into purmorphamine’s mechanism of action indicates that it directly binds to and activates the 7-transmembrane Smo receptor of the Hedgehog signaling pathway.{14874,14872}
Brand:CaymanSKU:10009634 - 1 mgAvailable on backorder
Small molecules that promote osteoblast differentiation might be useful as therapeutic agents for bone diseases such as osteoporosis. Purmorphamine is a 2,6,9-trisubstituted purine that promotes the differentiation of both human and mouse mesenchymal progenitor cells into osteoblasts.{14871,14873} The EC50 value for differentiation of C3H10T1/2 cells based on alkaline phosphatase expression is 1 µM.{14871} Investigation into purmorphamine’s mechanism of action indicates that it directly binds to and activates the 7-transmembrane Smo receptor of the Hedgehog signaling pathway.{14874,14872}
Brand:CaymanSKU:10009634 - 10 mgAvailable on backorder
Small molecules that promote osteoblast differentiation might be useful as therapeutic agents for bone diseases such as osteoporosis. Purmorphamine is a 2,6,9-trisubstituted purine that promotes the differentiation of both human and mouse mesenchymal progenitor cells into osteoblasts.{14871,14873} The EC50 value for differentiation of C3H10T1/2 cells based on alkaline phosphatase expression is 1 µM.{14871} Investigation into purmorphamine’s mechanism of action indicates that it directly binds to and activates the 7-transmembrane Smo receptor of the Hedgehog signaling pathway.{14874,14872}
Brand:CaymanSKU:10009634 - 25 mgAvailable on backorder
Small molecules that promote osteoblast differentiation might be useful as therapeutic agents for bone diseases such as osteoporosis. Purmorphamine is a 2,6,9-trisubstituted purine that promotes the differentiation of both human and mouse mesenchymal progenitor cells into osteoblasts.{14871,14873} The EC50 value for differentiation of C3H10T1/2 cells based on alkaline phosphatase expression is 1 µM.{14871} Investigation into purmorphamine’s mechanism of action indicates that it directly binds to and activates the 7-transmembrane Smo receptor of the Hedgehog signaling pathway.{14874,14872}
Brand:CaymanSKU:10009634 - 5 mgAvailable on backorder
Puromycin is an aminonucleoside antibiotic, derived from S. alboniger, that blocks protein synthesis in both prokaryotes and eukaryotes by causing premature termination of nascent polypeptide chains.{21743} A portion of the puromycin molecule resembles the 3′ end of aminoacylated tRNA.{21742} It enters the A site of the ribosome and attaches to the growing polypeptide chain at the peptidyl-transferase center, causing the formation of a puromycylated nascent chain and premature chain release.{21744} The 3′ position contains an amide linkage instead of the normal ester linkage of tRNA, making it much more resistant to hydrolysis and halting the activity of the ribosome.{21744} These properties of puromycin have been exploited in assays for peptide-bond formation and elongation and also the antibiotic is often used as selective agent in cell culture systems.
Brand:CaymanSKU:- Puromycin is an aminonucleoside antibiotic, derived from S. alboniger, that blocks protein synthesis in both prokaryotes and eukaryotes by causing premature termination of nascent polypeptide chains.{21743} A portion of the puromycin molecule resembles the 3′ end of aminoacylated tRNA.{21742} It enters the A site of the ribosome and attaches to the growing polypeptide chain at the peptidyl-transferase center, causing the formation of a puromycylated nascent chain and premature chain release.{21744} The 3′ position contains an amide linkage instead of the normal ester linkage of tRNA, making it much more resistant to hydrolysis and halting the activity of the ribosome.{21744} These properties of puromycin have been exploited in assays for peptide-bond formation and elongation and also the antibiotic is often used as selective agent in cell culture systems.
Brand:CaymanSKU:- Puromycin is an aminonucleoside antibiotic, derived from S. alboniger, that blocks protein synthesis in both prokaryotes and eukaryotes by causing premature termination of nascent polypeptide chains.{21743} A portion of the puromycin molecule resembles the 3′ end of aminoacylated tRNA.{21742} It enters the A site of the ribosome and attaches to the growing polypeptide chain at the peptidyl-transferase center, causing the formation of a puromycylated nascent chain and premature chain release.{21744} The 3′ position contains an amide linkage instead of the normal ester linkage of tRNA, making it much more resistant to hydrolysis and halting the activity of the ribosome.{21744} These properties of puromycin have been exploited in assays for peptide-bond formation and elongation and also the antibiotic is often used as selective agent in cell culture systems.
Brand:CaymanSKU:- Puromycin is an aminonucleoside antibiotic, derived from S. alboniger, that blocks protein synthesis in both prokaryotes and eukaryotes by causing premature termination of nascent polypeptide chains.{21743} A portion of the puromycin molecule resembles the 3′ end of aminoacylated tRNA.{21742} It enters the A site of the ribosome and attaches to the growing polypeptide chain at the peptidyl-transferase center, causing the formation of a puromycylated nascent chain and premature chain release.{21744} The 3′ position contains an amide linkage instead of the normal ester linkage of tRNA, making it much more resistant to hydrolysis and halting the activity of the ribosome.{21744} These properties of puromycin have been exploited in assays for peptide-bond formation and elongation and also the antibiotic is often used as selective agent in cell culture systems.
Brand:CaymanSKU:-
Puromycin (Item No. 13884) is an aminonucleoside antibiotic that blocks protein synthesis in both prokaryotes and eukaryotes by causing premature termination of nascent polypeptide chains.{21743} Puromycin aminonucleoside (PANS) is the aminonucleoside portion of puromycin. This analog cannot inhibit protein synthesis or induce apoptosis. Instead it is used to induce nephropathy in laboratory animal models to study focal and segmental glomerulosclerosis, the induction of nephrosis, and the events leading to proteinuria.{25326} When administered to rats at 0.5-5 μM, PANS affects glomerular epithelial cell adhesion, reducing α3β1 integrin expression.{25327} PANS also has been shown to decrease nephrin and podocin expression.{25325}
Brand:CaymanSKU:- Puromycin (Item No. 13884) is an aminonucleoside antibiotic that blocks protein synthesis in both prokaryotes and eukaryotes by causing premature termination of nascent polypeptide chains.{21743} Puromycin aminonucleoside (PANS) is the aminonucleoside portion of puromycin. This analog cannot inhibit protein synthesis or induce apoptosis. Instead it is used to induce nephropathy in laboratory animal models to study focal and segmental glomerulosclerosis, the induction of nephrosis, and the events leading to proteinuria.{25326} When administered to rats at 0.5-5 μM, PANS affects glomerular epithelial cell adhesion, reducing α3β1 integrin expression.{25327} PANS also has been shown to decrease nephrin and podocin expression.{25325}
Brand:CaymanSKU:- Puromycin (Item No. 13884) is an aminonucleoside antibiotic that blocks protein synthesis in both prokaryotes and eukaryotes by causing premature termination of nascent polypeptide chains.{21743} Puromycin aminonucleoside (PANS) is the aminonucleoside portion of puromycin. This analog cannot inhibit protein synthesis or induce apoptosis. Instead it is used to induce nephropathy in laboratory animal models to study focal and segmental glomerulosclerosis, the induction of nephrosis, and the events leading to proteinuria.{25326} When administered to rats at 0.5-5 μM, PANS affects glomerular epithelial cell adhesion, reducing α3β1 integrin expression.{25327} PANS also has been shown to decrease nephrin and podocin expression.{25325}
Brand:CaymanSKU:- Puromycin (Item No. 13884) is an aminonucleoside antibiotic that blocks protein synthesis in both prokaryotes and eukaryotes by causing premature termination of nascent polypeptide chains.{21743} Puromycin aminonucleoside (PANS) is the aminonucleoside portion of puromycin. This analog cannot inhibit protein synthesis or induce apoptosis. Instead it is used to induce nephropathy in laboratory animal models to study focal and segmental glomerulosclerosis, the induction of nephrosis, and the events leading to proteinuria.{25326} When administered to rats at 0.5-5 μM, PANS affects glomerular epithelial cell adhesion, reducing α3β1 integrin expression.{25327} PANS also has been shown to decrease nephrin and podocin expression.{25325}
Brand:CaymanSKU:-
Purpurin is a naturally occurring reddish-yellow pigment found in madder root (R. tinctorum) that has been used both in herbal remedies and as food coloring. It can also be synthetically derived from 9,10-anthraquinone. Purpurin is protective against a number of food-derived heterocyclic amines in bacterial mutagenicity assays through its inhibition of CYP450-dependent N-hydroxylation and reduction of N-hydroxylamines.{21124} Purpurine can also inhibit (IC50 = 6.6 μM) spermidine-induced autoactivation of plasma hyaluronan-binding protein, a serine protease that can activate coagulation factor VII and prourokinase.{21123}
Brand:CaymanSKU:11752 - 10 gAvailable on backorder
Purpurin is a naturally occurring reddish-yellow pigment found in madder root (R. tinctorum) that has been used both in herbal remedies and as food coloring. It can also be synthetically derived from 9,10-anthraquinone. Purpurin is protective against a number of food-derived heterocyclic amines in bacterial mutagenicity assays through its inhibition of CYP450-dependent N-hydroxylation and reduction of N-hydroxylamines.{21124} Purpurine can also inhibit (IC50 = 6.6 μM) spermidine-induced autoactivation of plasma hyaluronan-binding protein, a serine protease that can activate coagulation factor VII and prourokinase.{21123}
Brand:CaymanSKU:11752 - 25 gAvailable on backorder
Purpurin is a naturally occurring reddish-yellow pigment found in madder root (R. tinctorum) that has been used both in herbal remedies and as food coloring. It can also be synthetically derived from 9,10-anthraquinone. Purpurin is protective against a number of food-derived heterocyclic amines in bacterial mutagenicity assays through its inhibition of CYP450-dependent N-hydroxylation and reduction of N-hydroxylamines.{21124} Purpurine can also inhibit (IC50 = 6.6 μM) spermidine-induced autoactivation of plasma hyaluronan-binding protein, a serine protease that can activate coagulation factor VII and prourokinase.{21123}
Brand:CaymanSKU:11752 - 5 gAvailable on backorder
Purpurogallin is a phenol that has been found in D. divisa and a derivative of pyrogallol (Item No. 20347) that has diverse biological activities, including antimicrobial, antioxidant, and enzyme inhibitory properties.{53372,53373,53374,53375,53376,53377} It is active against the Gram-positive bacteria S. aureus, methicillin-resistant S. aureus (MRSA), S. epidermidis, and B. subtilis (MICs = 11-110 µg/ml), the Gram-negative bacteria S. marcescens, P. vulgaris, K. pneumoniae, E. coli, S. typhi, and E. cloacae (MIC = 110 µg/ml for all), as well as P. falciparum strain FCB1 clone NC-1 (IC50 = 55 µM).{53372,53374} Purpurogallin (2, 5, and 10 µM) scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in a cell-free assay and reduces hydrogen peroxide- and radiation-induced production of reactive oxygen species (ROS) in HaCaT keratinocytes.{53373} It inhibits the activity of EGFR, glutathione-S-transferase (GST), prolyl endopeptidase, and glyoxalase I (IC50s = 27.5, 8, 16, and 50 µM, respectively), as well as catechol O-methyltransferase (COMT; Ki = 0.074 µM), in cell-free assays.{53372,53374,53375,53376,53377}
Brand:CaymanSKU:29689 - 1 gAvailable on backorder
Purpurogallin is a phenol that has been found in D. divisa and a derivative of pyrogallol (Item No. 20347) that has diverse biological activities, including antimicrobial, antioxidant, and enzyme inhibitory properties.{53372,53373,53374,53375,53376,53377} It is active against the Gram-positive bacteria S. aureus, methicillin-resistant S. aureus (MRSA), S. epidermidis, and B. subtilis (MICs = 11-110 µg/ml), the Gram-negative bacteria S. marcescens, P. vulgaris, K. pneumoniae, E. coli, S. typhi, and E. cloacae (MIC = 110 µg/ml for all), as well as P. falciparum strain FCB1 clone NC-1 (IC50 = 55 µM).{53372,53374} Purpurogallin (2, 5, and 10 µM) scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in a cell-free assay and reduces hydrogen peroxide- and radiation-induced production of reactive oxygen species (ROS) in HaCaT keratinocytes.{53373} It inhibits the activity of EGFR, glutathione-S-transferase (GST), prolyl endopeptidase, and glyoxalase I (IC50s = 27.5, 8, 16, and 50 µM, respectively), as well as catechol O-methyltransferase (COMT; Ki = 0.074 µM), in cell-free assays.{53372,53374,53375,53376,53377}
Brand:CaymanSKU:29689 - 100 mgAvailable on backorder
Purpurogallin is a phenol that has been found in D. divisa and a derivative of pyrogallol (Item No. 20347) that has diverse biological activities, including antimicrobial, antioxidant, and enzyme inhibitory properties.{53372,53373,53374,53375,53376,53377} It is active against the Gram-positive bacteria S. aureus, methicillin-resistant S. aureus (MRSA), S. epidermidis, and B. subtilis (MICs = 11-110 µg/ml), the Gram-negative bacteria S. marcescens, P. vulgaris, K. pneumoniae, E. coli, S. typhi, and E. cloacae (MIC = 110 µg/ml for all), as well as P. falciparum strain FCB1 clone NC-1 (IC50 = 55 µM).{53372,53374} Purpurogallin (2, 5, and 10 µM) scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in a cell-free assay and reduces hydrogen peroxide- and radiation-induced production of reactive oxygen species (ROS) in HaCaT keratinocytes.{53373} It inhibits the activity of EGFR, glutathione-S-transferase (GST), prolyl endopeptidase, and glyoxalase I (IC50s = 27.5, 8, 16, and 50 µM, respectively), as well as catechol O-methyltransferase (COMT; Ki = 0.074 µM), in cell-free assays.{53372,53374,53375,53376,53377}
Brand:CaymanSKU:29689 - 50 mgAvailable on backorder
Purpurogallin is a phenol that has been found in D. divisa and a derivative of pyrogallol (Item No. 20347) that has diverse biological activities, including antimicrobial, antioxidant, and enzyme inhibitory properties.{53372,53373,53374,53375,53376,53377} It is active against the Gram-positive bacteria S. aureus, methicillin-resistant S. aureus (MRSA), S. epidermidis, and B. subtilis (MICs = 11-110 µg/ml), the Gram-negative bacteria S. marcescens, P. vulgaris, K. pneumoniae, E. coli, S. typhi, and E. cloacae (MIC = 110 µg/ml for all), as well as P. falciparum strain FCB1 clone NC-1 (IC50 = 55 µM).{53372,53374} Purpurogallin (2, 5, and 10 µM) scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in a cell-free assay and reduces hydrogen peroxide- and radiation-induced production of reactive oxygen species (ROS) in HaCaT keratinocytes.{53373} It inhibits the activity of EGFR, glutathione-S-transferase (GST), prolyl endopeptidase, and glyoxalase I (IC50s = 27.5, 8, 16, and 50 µM, respectively), as well as catechol O-methyltransferase (COMT; Ki = 0.074 µM), in cell-free assays.{53372,53374,53375,53376,53377}
Brand:CaymanSKU:29689 - 500 mgAvailable on backorder
Purvalanol A is a potent, cell-permeable, and selective inhibitor of cyclin-dependent kinases (CDKs) with IC50 values of 4, 70, 35, 850, and 75 nM for cdc2/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, Cdk4/cyclin D1 and Cdk5-p35, respectively.{6960,14995} Purvalanol A reversibly arrests synchronized cells in the G1 and G2 phase of the cell cycle, inhibiting both cell proliferation and cell death.{22865} At 10 μM, purvalanol A potently suppresses the anchorage-independent growth of c-Src-transformed cells as well as HT-29 and SW48 human colon cancer cells.{22866}
Brand:CaymanSKU:- Purvalanol A is a potent, cell-permeable, and selective inhibitor of cyclin-dependent kinases (CDKs) with IC50 values of 4, 70, 35, 850, and 75 nM for cdc2/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, Cdk4/cyclin D1 and Cdk5-p35, respectively.{6960,14995} Purvalanol A reversibly arrests synchronized cells in the G1 and G2 phase of the cell cycle, inhibiting both cell proliferation and cell death.{22865} At 10 μM, purvalanol A potently suppresses the anchorage-independent growth of c-Src-transformed cells as well as HT-29 and SW48 human colon cancer cells.{22866}
Brand:CaymanSKU:- Purvalanol A is a potent, cell-permeable, and selective inhibitor of cyclin-dependent kinases (CDKs) with IC50 values of 4, 70, 35, 850, and 75 nM for cdc2/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, Cdk4/cyclin D1 and Cdk5-p35, respectively.{6960,14995} Purvalanol A reversibly arrests synchronized cells in the G1 and G2 phase of the cell cycle, inhibiting both cell proliferation and cell death.{22865} At 10 μM, purvalanol A potently suppresses the anchorage-independent growth of c-Src-transformed cells as well as HT-29 and SW48 human colon cancer cells.{22866}
Brand:CaymanSKU:- Purvalanol A is a potent, cell-permeable, and selective inhibitor of cyclin-dependent kinases (CDKs) with IC50 values of 4, 70, 35, 850, and 75 nM for cdc2/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, Cdk4/cyclin D1 and Cdk5-p35, respectively.{6960,14995} Purvalanol A reversibly arrests synchronized cells in the G1 and G2 phase of the cell cycle, inhibiting both cell proliferation and cell death.{22865} At 10 μM, purvalanol A potently suppresses the anchorage-independent growth of c-Src-transformed cells as well as HT-29 and SW48 human colon cancer cells.{22866}
Brand:CaymanSKU:-
Cyclin-dependent kinases (CDKs) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy.{21810} Purvalanol B is a CDK inhibitor that most potently inhibits Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p35, and Cdk2/cyclin B (IC50s = 6, 9, 6, and 6 nM, respectively).{6960} It is inactive against Cdk4/cyclin D1 as well as several other protein kinases. Purvalanol B is a 2,6,9-trisubstituted purine that, at micromolar doses, inhibits the growth of parasites, including Plasmodium.{30689,30688}
Brand:CaymanSKU:-Available on backorder
Cyclin-dependent kinases (CDKs) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy.{21810} Purvalanol B is a CDK inhibitor that most potently inhibits Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p35, and Cdk2/cyclin B (IC50s = 6, 9, 6, and 6 nM, respectively).{6960} It is inactive against Cdk4/cyclin D1 as well as several other protein kinases. Purvalanol B is a 2,6,9-trisubstituted purine that, at micromolar doses, inhibits the growth of parasites, including Plasmodium.{30689,30688}
Brand:CaymanSKU:-Available on backorder
Cyclin-dependent kinases (CDKs) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy.{21810} Purvalanol B is a CDK inhibitor that most potently inhibits Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p35, and Cdk2/cyclin B (IC50s = 6, 9, 6, and 6 nM, respectively).{6960} It is inactive against Cdk4/cyclin D1 as well as several other protein kinases. Purvalanol B is a 2,6,9-trisubstituted purine that, at micromolar doses, inhibits the growth of parasites, including Plasmodium.{30689,30688}
Brand:CaymanSKU:-Available on backorder
Cyclin-dependent kinases (CDKs) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy.{21810} Purvalanol B is a CDK inhibitor that most potently inhibits Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p35, and Cdk2/cyclin B (IC50s = 6, 9, 6, and 6 nM, respectively).{6960} It is inactive against Cdk4/cyclin D1 as well as several other protein kinases. Purvalanol B is a 2,6,9-trisubstituted purine that, at micromolar doses, inhibits the growth of parasites, including Plasmodium.{30689,30688}
Brand:CaymanSKU:-Available on backorder
PX 12 is a competitive, irreversible inhibitor of thioredoxin 1 (Trx1), acting by binding to Cys73 of this enzyme.{22315} As Trx1 is overexpressed in certain cancers, PX 12 is effective in suppressing the growth of cancer cells, with growth inhibition in a panel of 60 human tumors significantly correlated with expression of Trx1 mRNA.{22325,22314} Through its effects on Trx1, PX 12 reduces hypoxia-induced HIF-1α protein levels (IC50 = 7.2 μM), as well as expression of VEGF (IC50 = 10.4 μM) and iNOS (IC50 = 18.1 μM), culminating in attenuation of the proliferation of MCF-7 cells (IC50 = 1.9 μM) and HT-29 cells (IC50 = 2.9 μM) as well as reduced microvessel density in MCF-7 tumor xenografts.{22317} PX 12 also blocks Trx-mediated activation of extracellular transglutaminase 2 (IC50 = ~3 μM) and Trx-1-increased expression and translation of CYP1B1.{22313,22312}
Brand:CaymanSKU:- PX 12 is a competitive, irreversible inhibitor of thioredoxin 1 (Trx1), acting by binding to Cys73 of this enzyme.{22315} As Trx1 is overexpressed in certain cancers, PX 12 is effective in suppressing the growth of cancer cells, with growth inhibition in a panel of 60 human tumors significantly correlated with expression of Trx1 mRNA.{22325,22314} Through its effects on Trx1, PX 12 reduces hypoxia-induced HIF-1α protein levels (IC50 = 7.2 μM), as well as expression of VEGF (IC50 = 10.4 μM) and iNOS (IC50 = 18.1 μM), culminating in attenuation of the proliferation of MCF-7 cells (IC50 = 1.9 μM) and HT-29 cells (IC50 = 2.9 μM) as well as reduced microvessel density in MCF-7 tumor xenografts.{22317} PX 12 also blocks Trx-mediated activation of extracellular transglutaminase 2 (IC50 = ~3 μM) and Trx-1-increased expression and translation of CYP1B1.{22313,22312}
Brand:CaymanSKU:- PX 12 is a competitive, irreversible inhibitor of thioredoxin 1 (Trx1), acting by binding to Cys73 of this enzyme.{22315} As Trx1 is overexpressed in certain cancers, PX 12 is effective in suppressing the growth of cancer cells, with growth inhibition in a panel of 60 human tumors significantly correlated with expression of Trx1 mRNA.{22325,22314} Through its effects on Trx1, PX 12 reduces hypoxia-induced HIF-1α protein levels (IC50 = 7.2 μM), as well as expression of VEGF (IC50 = 10.4 μM) and iNOS (IC50 = 18.1 μM), culminating in attenuation of the proliferation of MCF-7 cells (IC50 = 1.9 μM) and HT-29 cells (IC50 = 2.9 μM) as well as reduced microvessel density in MCF-7 tumor xenografts.{22317} PX 12 also blocks Trx-mediated activation of extracellular transglutaminase 2 (IC50 = ~3 μM) and Trx-1-increased expression and translation of CYP1B1.{22313,22312}
Brand:CaymanSKU:-
PX 866 is a ring-opened analog of wortmannin (Item No. 10010591) that potently and irreversibly inhibits PI3K (IC50 = 0.1-88 nM).{24458,18123} It less potently blocks the activity of mammalian target of rapamycin (mTOR, IC50 = 3.1 µM).{18123} PX 866 exhibits single agent in vivo anti-tumor activity and increases the anti-tumor effects of cisplatin and radiation treatment.{24458,24459} In cancer cells grown in three-dimensional cultures, PX 866 reduces cell growth and motility without causing cytotoxicity.{24457} Consistent with having cytostatic effects, PX 866 dosing is associated with prolonged stable disease in cancer patients.{24460}
Brand:CaymanSKU:-