Cayman
Showing 36301–36450 of 45550 results
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Immunogen: Synthetic peptide from the internal region of human mPGES-2 • Host: Rabbit • Species Reactivity: (+) Human, African green monkey, bovine, mouse, ovine, and rat • Cross Reactivity: (+) mPGES-2; (−) mPGEs-1 and cPGES • Applications: IHC and WB
Brand:CaymanSKU:160145- 1 ea Prostaglandin E synthase-2 (microsomal) (mPGES-2) is membrane-associated PGE2-producing enzyme.{10238,9892} Unlike mPGES-1, mPGES-2 does not require glutathione for catalytic activity and is activated in the presence of a broad range of reducing agents. Cayman Chemical’s mPGES-2 Polyclonal Antibody can be used for Western blot applications. The antibody recognizes mPGES-2 at 33 kDa from human, mouse, sheep, cow, and monkey samples.
Brand:CaymanSKU:160145 - 1 eaAvailable on backorder
Immunogen: Synthetic peptide from the internal region of human mPGES-2 • Host: Rabbit • Species Reactivity: (+) Human, African green monkey, bovine, mouse, ovine, and rat • Cross Reactivity: (+) mPGES-2; (−) mPGEs-1 and cPGES • Applications: IHC and WB
Brand:CaymanSKU:160145- 1 eaAvailable on backorder
PGE1 is the theoretical cyclooxygenase metabolite of dihomo-γ-linolenic acid (DGLA), but it is virtually undetectable in the plasma of normal humans or other animals.{5702} Its pharmacology includes vasodilation, hypotension, and anti-platelet activities. The IC50 of PGE1 for the inhibition of ADP-induced human platelet aggregation is 40 nM.{960,1751} The vasorelaxant and anti-hypertensive effects of PGE1 are used to treat male erectile dysfunction and to provide emergency vasodilation of the patent ductus arteriosus in infants whose cardiac anomalies require pulmonary shunting for survival.{3468,5876} In human males, the intracavernosal effective dose range for PGE1 is 2 to 80 µg, and the transurethral range is 125 to 1,000 µg.{3468}
Brand:CaymanSKU:13010 - 1 mgAvailable on backorder
PGE1 is the theoretical cyclooxygenase metabolite of dihomo-γ-linolenic acid (DGLA), but it is virtually undetectable in the plasma of normal humans or other animals.{5702} Its pharmacology includes vasodilation, hypotension, and anti-platelet activities. The IC50 of PGE1 for the inhibition of ADP-induced human platelet aggregation is 40 nM.{960,1751} The vasorelaxant and anti-hypertensive effects of PGE1 are used to treat male erectile dysfunction and to provide emergency vasodilation of the patent ductus arteriosus in infants whose cardiac anomalies require pulmonary shunting for survival.{3468,5876} In human males, the intracavernosal effective dose range for PGE1 is 2 to 80 µg, and the transurethral range is 125 to 1,000 µg.{3468}
Brand:CaymanSKU:13010 - 10 mgAvailable on backorder
PGE1 is the theoretical cyclooxygenase metabolite of dihomo-γ-linolenic acid (DGLA), but it is virtually undetectable in the plasma of normal humans or other animals.{5702} Its pharmacology includes vasodilation, hypotension, and anti-platelet activities. The IC50 of PGE1 for the inhibition of ADP-induced human platelet aggregation is 40 nM.{960,1751} The vasorelaxant and anti-hypertensive effects of PGE1 are used to treat male erectile dysfunction and to provide emergency vasodilation of the patent ductus arteriosus in infants whose cardiac anomalies require pulmonary shunting for survival.{3468,5876} In human males, the intracavernosal effective dose range for PGE1 is 2 to 80 µg, and the transurethral range is 125 to 1,000 µg.{3468}
Brand:CaymanSKU:13010 - 5 mgAvailable on backorder
PGE1 is the theoretical cyclooxygenase metabolite of dihomo-γ-linolenic acid (DGLA), but it is virtually undetectable in the plasma of normal humans or other animals.{5702} Its pharmacology includes vasodilation, hypotension, and anti-platelet activities. The IC50 of PGE1 for the inhibition of ADP-induced human platelet aggregation is 40 nM.{960,1751} The vasorelaxant and anti-hypertensive effects of PGE1 are used to treat male erectile dysfunction and to provide emergency vasodilation of the patent ductus arteriosus in infants whose cardiac anomalies require pulmonary shunting for survival.{3468,5876} In human males, the intracavernosal effective dose range for PGE1 is 2 to 80 µg, and the transurethral range is 125 to 1,000 µg.{3468}
Brand:CaymanSKU:13010 - 50 mgAvailable on backorder
Prostaglandin E1 (PGE1) alcohol is a non-irritant bronchodilator, with relaxant activity on the human bronchial muscle in vitro, comparable to PGE1 at concentrations of 0.01 to 10.0 µg/ml.{2118,2119} Asthmatics receiving single dose inhalation treatments reported significant but short-acting bronchodilation at doses of 10 and 30 µg.{2118} PGE1 alcohol binds to the mouse recombinant EP3 and EP4 receptors with Ki values of 330 and 190 nM, respectively.{6640}
Brand:CaymanSKU:13020 - 1 mgAvailable on backorder
Prostaglandin E1 (PGE1) alcohol is a non-irritant bronchodilator, with relaxant activity on the human bronchial muscle in vitro, comparable to PGE1 at concentrations of 0.01 to 10.0 µg/ml.{2118,2119} Asthmatics receiving single dose inhalation treatments reported significant but short-acting bronchodilation at doses of 10 and 30 µg.{2118} PGE1 alcohol binds to the mouse recombinant EP3 and EP4 receptors with Ki values of 330 and 190 nM, respectively.{6640}
Brand:CaymanSKU:13020 - 10 mgAvailable on backorder
Prostaglandin E1 (PGE1) alcohol is a non-irritant bronchodilator, with relaxant activity on the human bronchial muscle in vitro, comparable to PGE1 at concentrations of 0.01 to 10.0 µg/ml.{2118,2119} Asthmatics receiving single dose inhalation treatments reported significant but short-acting bronchodilation at doses of 10 and 30 µg.{2118} PGE1 alcohol binds to the mouse recombinant EP3 and EP4 receptors with Ki values of 330 and 190 nM, respectively.{6640}
Brand:CaymanSKU:13020 - 5 mgAvailable on backorder
Prostaglandin E1 (PGE1) alcohol is a non-irritant bronchodilator, with relaxant activity on the human bronchial muscle in vitro, comparable to PGE1 at concentrations of 0.01 to 10.0 µg/ml.{2118,2119} Asthmatics receiving single dose inhalation treatments reported significant but short-acting bronchodilation at doses of 10 and 30 µg.{2118} PGE1 alcohol binds to the mouse recombinant EP3 and EP4 receptors with Ki values of 330 and 190 nM, respectively.{6640}
Brand:CaymanSKU:13020 - 500 µgAvailable on backorder
Prostaglandin E1 ethanolamide (PGE1-EA) is the ethanolamine-amide analog of PGE1. Conversion of AEA, the ethanolamide of arachidonic acid, to PGE2-EA has been demonstrated in vitro.{5089,11045} It is not established whether this conversion occurs in whole animals, nor has the pharmacology of the resultant prostaglandin ethanolamides been rigorously studied.
Brand:CaymanSKU:13012 - 1 mgAvailable on backorder
Prostaglandin E1 ethanolamide (PGE1-EA) is the ethanolamine-amide analog of PGE1. Conversion of AEA, the ethanolamide of arachidonic acid, to PGE2-EA has been demonstrated in vitro.{5089,11045} It is not established whether this conversion occurs in whole animals, nor has the pharmacology of the resultant prostaglandin ethanolamides been rigorously studied.
Brand:CaymanSKU:13012 - 10 mgAvailable on backorder
Prostaglandin E1 ethanolamide (PGE1-EA) is the ethanolamine-amide analog of PGE1. Conversion of AEA, the ethanolamide of arachidonic acid, to PGE2-EA has been demonstrated in vitro.{5089,11045} It is not established whether this conversion occurs in whole animals, nor has the pharmacology of the resultant prostaglandin ethanolamides been rigorously studied.
Brand:CaymanSKU:13012 - 5 mgAvailable on backorder
Prostaglandin E1 (PGE1) is the theoretical cyclooxygenase metabolite of dihomo-γ-linolenic acid.{5702} Its pharmacology includes vasodilation, hypotension, and anti-platelet activities. The IC50 value of PGE1 for the inhibition of ADP-induced human platelet aggregation is 40 nM.{960,1751} PGE1 is used to treat male erectile dysfunction and to maintain ductus arteriosus patency in infants.{3468,5876} PGE1 ethyl ester is an esterified form of the free acid which may be more amenable for certain applications.
Brand:CaymanSKU:9001730 - 1 mgAvailable on backorder
Prostaglandin E1 (PGE1) is the theoretical cyclooxygenase metabolite of dihomo-γ-linolenic acid.{5702} Its pharmacology includes vasodilation, hypotension, and anti-platelet activities. The IC50 value of PGE1 for the inhibition of ADP-induced human platelet aggregation is 40 nM.{960,1751} PGE1 is used to treat male erectile dysfunction and to maintain ductus arteriosus patency in infants.{3468,5876} PGE1 ethyl ester is an esterified form of the free acid which may be more amenable for certain applications.
Brand:CaymanSKU:9001730 - 100 µgAvailable on backorder
Prostaglandin E1 (PGE1) is the theoretical cyclooxygenase metabolite of dihomo-γ-linolenic acid.{5702} Its pharmacology includes vasodilation, hypotension, and anti-platelet activities. The IC50 value of PGE1 for the inhibition of ADP-induced human platelet aggregation is 40 nM.{960,1751} PGE1 is used to treat male erectile dysfunction and to maintain ductus arteriosus patency in infants.{3468,5876} PGE1 ethyl ester is an esterified form of the free acid which may be more amenable for certain applications.
Brand:CaymanSKU:9001730 - 5 mgAvailable on backorder
Prostaglandin E1 (PGE1) is the theoretical cyclooxygenase metabolite of dihomo-γ-linolenic acid.{5702} Its pharmacology includes vasodilation, hypotension, and anti-platelet activities. The IC50 value of PGE1 for the inhibition of ADP-induced human platelet aggregation is 40 nM.{960,1751} PGE1 is used to treat male erectile dysfunction and to maintain ductus arteriosus patency in infants.{3468,5876} PGE1 ethyl ester is an esterified form of the free acid which may be more amenable for certain applications.
Brand:CaymanSKU:9001730 - 500 µgAvailable on backorder
Prostaglandin E1 isopropyl ester is an ester prodrug form of prostaglandin E1 (PGE1; Item No. 13010) with enhanced lipid solubility.{49642,49641} The ester functional group on PGE1 isopropyl ester is readily hydrolyzed in cells and in vivo to release active PGE1.{49642} PGE1 isopropyl ester exhibits a faster penetration flux than the free acid form of PGE1 when applied topically to isolated mouse skin. Topical administration of PGE1 isopropyl ester (1 mM) reduces fluid pressure within human dermal fibroblast cell aggregates.{49641}
Brand:CaymanSKU:9001729 - 1 mgAvailable on backorder
Prostaglandin E1 isopropyl ester is an ester prodrug form of prostaglandin E1 (PGE1; Item No. 13010) with enhanced lipid solubility.{49642,49641} The ester functional group on PGE1 isopropyl ester is readily hydrolyzed in cells and in vivo to release active PGE1.{49642} PGE1 isopropyl ester exhibits a faster penetration flux than the free acid form of PGE1 when applied topically to isolated mouse skin. Topical administration of PGE1 isopropyl ester (1 mM) reduces fluid pressure within human dermal fibroblast cell aggregates.{49641}
Brand:CaymanSKU:9001729 - 100 µgAvailable on backorder
Prostaglandin E1 isopropyl ester is an ester prodrug form of prostaglandin E1 (PGE1; Item No. 13010) with enhanced lipid solubility.{49642,49641} The ester functional group on PGE1 isopropyl ester is readily hydrolyzed in cells and in vivo to release active PGE1.{49642} PGE1 isopropyl ester exhibits a faster penetration flux than the free acid form of PGE1 when applied topically to isolated mouse skin. Topical administration of PGE1 isopropyl ester (1 mM) reduces fluid pressure within human dermal fibroblast cell aggregates.{49641}
Brand:CaymanSKU:9001729 - 5 mgAvailable on backorder
Prostaglandin E1 isopropyl ester is an ester prodrug form of prostaglandin E1 (PGE1; Item No. 13010) with enhanced lipid solubility.{49642,49641} The ester functional group on PGE1 isopropyl ester is readily hydrolyzed in cells and in vivo to release active PGE1.{49642} PGE1 isopropyl ester exhibits a faster penetration flux than the free acid form of PGE1 when applied topically to isolated mouse skin. Topical administration of PGE1 isopropyl ester (1 mM) reduces fluid pressure within human dermal fibroblast cell aggregates.{49641}
Brand:CaymanSKU:9001729 - 500 µgAvailable on backorder
Prostaglandin E1-d4 (PGE1-d4) contains four deuterium atoms at the 3, 3′, 4, and 4′ positions. It is intended for use as an internal standard for the quantification of PGE1 by GC- or LC-mass spectrometry. PGE1 is the theoretical cyclooxygenase metabolite of dihomo-γ-linolenic acid (DGLA), but it is virtually undetectable in the plasma of normal humans or other animals.{5702} Its pharmacology includes vasodilation, hypotension, and anti-platelet activities. The IC50 of PGE1 for the inhibition of ADP-induced human platelet aggregation is 40 nM.{960,1751} The vasorelaxant and anti-hypertensive effects of PGE1 are used to treat male erectile dysfunction and to provide emergency vasodilation of the patent ductus arteriosus in infants whose cardiac anomalies require pulmonary shunting for survival.{3468,5876} In human males, the intracavernosal effective dose range for PGE1 is 2 to 80 µg, and the transurethral range is 125 to 1,000 µg.{3468}
Brand:CaymanSKU:313010 - 100 µgAvailable on backorder
Prostaglandin E1-d4 (PGE1-d4) contains four deuterium atoms at the 3, 3′, 4, and 4′ positions. It is intended for use as an internal standard for the quantification of PGE1 by GC- or LC-mass spectrometry. PGE1 is the theoretical cyclooxygenase metabolite of dihomo-γ-linolenic acid (DGLA), but it is virtually undetectable in the plasma of normal humans or other animals.{5702} Its pharmacology includes vasodilation, hypotension, and anti-platelet activities. The IC50 of PGE1 for the inhibition of ADP-induced human platelet aggregation is 40 nM.{960,1751} The vasorelaxant and anti-hypertensive effects of PGE1 are used to treat male erectile dysfunction and to provide emergency vasodilation of the patent ductus arteriosus in infants whose cardiac anomalies require pulmonary shunting for survival.{3468,5876} In human males, the intracavernosal effective dose range for PGE1 is 2 to 80 µg, and the transurethral range is 125 to 1,000 µg.{3468}
Brand:CaymanSKU:313010 - 50 µgAvailable on backorder
Prostaglandin E1-d4 (PGE1-d4) contains four deuterium atoms at the 3, 3′, 4, and 4′ positions. It is intended for use as an internal standard for the quantification of PGE1 by GC- or LC-mass spectrometry. PGE1 is the theoretical cyclooxygenase metabolite of dihomo-γ-linolenic acid (DGLA), but it is virtually undetectable in the plasma of normal humans or other animals.{5702} Its pharmacology includes vasodilation, hypotension, and anti-platelet activities. The IC50 of PGE1 for the inhibition of ADP-induced human platelet aggregation is 40 nM.{960,1751} The vasorelaxant and anti-hypertensive effects of PGE1 are used to treat male erectile dysfunction and to provide emergency vasodilation of the patent ductus arteriosus in infants whose cardiac anomalies require pulmonary shunting for survival.{3468,5876} In human males, the intracavernosal effective dose range for PGE1 is 2 to 80 µg, and the transurethral range is 125 to 1,000 µg.{3468}
Brand:CaymanSKU:313010 - 500 µgAvailable on backorder
PGE2 is one of the primary COX products of arachidonic acid (Item No. 90010) and one of the most widely investigated prostaglandins. Its activity influences inflammation, fertility and parturition, gastric mucosal integrity, and immune modulation.{1585,1558,437,1330} The effects of PGE2 are transduced by at least four distinct receptors designated EP1, EP2, EP3, and EP4.{1422} Affinity constants (Kd) of PGE2 for these receptors range from 1-10 nM depending on the receptor subtype and tissue.
Brand:CaymanSKU:- PGE2 is one of the primary COX products of arachidonic acid (Item No. 90010) and one of the most widely investigated prostaglandins. Its activity influences inflammation, fertility and parturition, gastric mucosal integrity, and immune modulation.{1585,1558,437,1330} The effects of PGE2 are transduced by at least four distinct receptors designated EP1, EP2, EP3, and EP4.{1422} Affinity constants (Kd) of PGE2 for these receptors range from 1-10 nM depending on the receptor subtype and tissue.
Brand:CaymanSKU:- PGE2 is one of the primary COX products of arachidonic acid (Item No. 90010) and one of the most widely investigated prostaglandins. Its activity influences inflammation, fertility and parturition, gastric mucosal integrity, and immune modulation.{1585,1558,437,1330} The effects of PGE2 are transduced by at least four distinct receptors designated EP1, EP2, EP3, and EP4.{1422} Affinity constants (Kd) of PGE2 for these receptors range from 1-10 nM depending on the receptor subtype and tissue.
Brand:CaymanSKU:- PGE2 is one of the primary COX products of arachidonic acid (Item No. 90010) and one of the most widely investigated prostaglandins. Its activity influences inflammation, fertility and parturition, gastric mucosal integrity, and immune modulation.{1585,1558,437,1330} The effects of PGE2 are transduced by at least four distinct receptors designated EP1, EP2, EP3, and EP4.{1422} Affinity constants (Kd) of PGE2 for these receptors range from 1-10 nM depending on the receptor subtype and tissue.
Brand:CaymanSKU:-
Prostaglandin E2 (PGE2) is a primary product of arachidonic acid metabolism in many cells. Like most eicosanoids, it does not exist preformed in any cellular reservoir. When cells are activated or exogenous free arachidonate is supplied, PGE2 is synthesized de novo and released into the extracellular space. In vivo, PGE2 is rapidly converted to an inactive metabolite (13,14-dihydro-15-keto PGE2) by the prostaglandin 15-dehydrogenase pathway.{581,182} The half-life of PGE2 in the circulatory system is approximately 30 seconds and normal plasma levels are 3-12 pg/ml.{366} Our PGE2 ELISA has been validated for use with urine, plasma, and culture media samples. In general, urine and culture media samples can be diluted, if necessary, and added directly to the assay well. Plasma samples should be purified prior to use. Because of the rapid metabolism of PGE2, the determination of in vivo PGE2 biosynthesis is often best accomplished by the measurement of PGE2 metabolites. Our Prostaglandin E Metabolite assay (Item No. 514531) converts all major PGE2 metabolites into a single stable derivative which is easily measurable by ELISA.
Brand:CaymanSKU:514010 - 480 solid wellsAvailable on backorder
Prostaglandin E2 (PGE2) is a primary product of arachidonic acid metabolism in many cells. Like most eicosanoids, it does not exist preformed in any cellular reservoir. When cells are activated or exogenous free arachidonate is supplied, PGE2 is synthesized de novo and released into the extracellular space. In vivo, PGE2 is rapidly converted to an inactive metabolite (13,14-dihydro-15-keto PGE2) by the prostaglandin 15-dehydrogenase pathway.{581,182} The half-life of PGE2 in the circulatory system is approximately 30 seconds and normal plasma levels are 3-12 pg/ml.{366} Our PGE2 ELISA has been validated for use with urine, plasma, and culture media samples. In general, urine and culture media samples can be diluted, if necessary, and added directly to the assay well. Plasma samples should be purified prior to use. Because of the rapid metabolism of PGE2, the determination of in vivo PGE2 biosynthesis is often best accomplished by the measurement of PGE2 metabolites. Our Prostaglandin E Metabolite assay (Item No. 514531) converts all major PGE2 metabolites into a single stable derivative which is easily measurable by ELISA.
Brand:CaymanSKU:514010 - 480 strip wellsAvailable on backorder
Prostaglandin E2 (PGE2) is a primary product of arachidonic acid metabolism in many cells. Like most eicosanoids, it does not exist preformed in any cellular reservoir. When cells are activated or exogenous free arachidonate is supplied, PGE2 is synthesized de novo and released into the extracellular space. In vivo, PGE2 is rapidly converted to an inactive metabolite (13,14-dihydro-15-keto PGE2) by the prostaglandin 15-dehydrogenase pathway.{581,182} The half-life of PGE2 in the circulatory system is approximately 30 seconds and normal plasma levels are 3-12 pg/ml.{366} Our PGE2 ELISA has been validated for use with urine, plasma, and culture media samples. In general, urine and culture media samples can be diluted, if necessary, and added directly to the assay well. Plasma samples should be purified prior to use. Because of the rapid metabolism of PGE2, the determination of in vivo PGE2 biosynthesis is often best accomplished by the measurement of PGE2 metabolites. Our Prostaglandin E Metabolite assay (Item No. 514531) converts all major PGE2 metabolites into a single stable derivative which is easily measurable by ELISA.
Brand:CaymanSKU:514010 - 96 solid wellsAvailable on backorder
Prostaglandin E2 (PGE2) is a primary product of arachidonic acid metabolism in many cells. Like most eicosanoids, it does not exist preformed in any cellular reservoir. When cells are activated or exogenous free arachidonate is supplied, PGE2 is synthesized de novo and released into the extracellular space. In vivo, PGE2 is rapidly converted to an inactive metabolite (13,14-dihydro-15-keto PGE2) by the prostaglandin 15-dehydrogenase pathway.{581,182} The half-life of PGE2 in the circulatory system is approximately 30 seconds and normal plasma levels are 3-12 pg/ml.{366} Our PGE2 ELISA has been validated for use with urine, plasma, and culture media samples. In general, urine and culture media samples can be diluted, if necessary, and added directly to the assay well. Plasma samples should be purified prior to use. Because of the rapid metabolism of PGE2, the determination of in vivo PGE2 biosynthesis is often best accomplished by the measurement of PGE2 metabolites. Our Prostaglandin E Metabolite assay (Item No. 514531) converts all major PGE2 metabolites into a single stable derivative which is easily measurable by ELISA.
Brand:CaymanSKU:514010 - 96 strip wellsAvailable on backorder
Brand:CaymanSKU:414014 - 1 eaAvailable on backorder
Prostaglandin E2 ethanolamide (PGE2-EA) is an analog of PGE2 (Item No. 14010) with improved water solubility and stability. PGE2-EA is formed via COX-2 metabolism of arachidonoyl ethanolamide (AEA; Item No. 90050) and acts as an agonist at E prostanoid (EP) receptors 1-4 (Kis = 2.45, 0.46, 0.2, and 0.51 μM, respectively).{11045,10926} It also inhibits indoleamine 2,3-dioxygenase-1 (IDO-1) in THP-1 cells and human monocytes (IC50s = 5.7 and 4.7 μM, respectively).{40333} PGE2-EA (10 μM) prevents morphological changes and F-actin rearrangement as well as reduces L-homocysteine-induced NLRP3 inflammasome formation and activation in podocytes.{41626} Ex vivo, PGE2-EA reduces luminal damage and lymphocyte infiltration in a human mucosal explant colitis model.{41627}
Brand:CaymanSKU:- Prostaglandin E2 ethanolamide (PGE2-EA) is an analog of PGE2 (Item No. 14010) with improved water solubility and stability. PGE2-EA is formed via COX-2 metabolism of arachidonoyl ethanolamide (AEA; Item No. 90050) and acts as an agonist at E prostanoid (EP) receptors 1-4 (Kis = 2.45, 0.46, 0.2, and 0.51 μM, respectively).{11045,10926} It also inhibits indoleamine 2,3-dioxygenase-1 (IDO-1) in THP-1 cells and human monocytes (IC50s = 5.7 and 4.7 μM, respectively).{40333} PGE2-EA (10 μM) prevents morphological changes and F-actin rearrangement as well as reduces L-homocysteine-induced NLRP3 inflammasome formation and activation in podocytes.{41626} Ex vivo, PGE2-EA reduces luminal damage and lymphocyte infiltration in a human mucosal explant colitis model.{41627}
Brand:CaymanSKU:- Prostaglandin E2 ethanolamide (PGE2-EA) is an analog of PGE2 (Item No. 14010) with improved water solubility and stability. PGE2-EA is formed via COX-2 metabolism of arachidonoyl ethanolamide (AEA; Item No. 90050) and acts as an agonist at E prostanoid (EP) receptors 1-4 (Kis = 2.45, 0.46, 0.2, and 0.51 μM, respectively).{11045,10926} It also inhibits indoleamine 2,3-dioxygenase-1 (IDO-1) in THP-1 cells and human monocytes (IC50s = 5.7 and 4.7 μM, respectively).{40333} PGE2-EA (10 μM) prevents morphological changes and F-actin rearrangement as well as reduces L-homocysteine-induced NLRP3 inflammasome formation and activation in podocytes.{41626} Ex vivo, PGE2-EA reduces luminal damage and lymphocyte infiltration in a human mucosal explant colitis model.{41627}
Brand:CaymanSKU:- Prostaglandin E2 ethanolamide (PGE2-EA) is an analog of PGE2 (Item No. 14010) with improved water solubility and stability. PGE2-EA is formed via COX-2 metabolism of arachidonoyl ethanolamide (AEA; Item No. 90050) and acts as an agonist at E prostanoid (EP) receptors 1-4 (Kis = 2.45, 0.46, 0.2, and 0.51 μM, respectively).{11045,10926} It also inhibits indoleamine 2,3-dioxygenase-1 (IDO-1) in THP-1 cells and human monocytes (IC50s = 5.7 and 4.7 μM, respectively).{40333} PGE2-EA (10 μM) prevents morphological changes and F-actin rearrangement as well as reduces L-homocysteine-induced NLRP3 inflammasome formation and activation in podocytes.{41626} Ex vivo, PGE2-EA reduces luminal damage and lymphocyte infiltration in a human mucosal explant colitis model.{41627}
Brand:CaymanSKU:-
Prostaglandin E2 ethanolamide (PGE2-EA) is an analog of PGE2 (Item No. 14010) with improved water solubility and stability. PGE2-EA is formed via COX-2 metabolism of arachidonoyl ethanolamide (AEA; Item No. 90050) and acts as an agonist at E prostanoid (EP) receptors 1-4 (Kis = 2.45, 0.46, 0.2, and 0.51 μM, respectively).{11045,10926} It also inhibits indoleamine 2,3-dioxygenase-1 (IDO-1) in THP-1 cells and human monocytes (IC50s = 5.7 and 4.7 μM, respectively).{40333} PGE2-EA (10 μM) prevents morphological changes and F-actin rearrangement as well as reduces L-homocysteine-induced NLRP3 inflammasome formation and activation in podocytes.{41626} Ex vivo, PGE2-EA reduces luminal damage and lymphocyte infiltration in a human mucosal explant colitis model.{41627} PGE2-EA MaxSpec® standard is a quantitative grade standard of PGE2-EA (Item No. 14012) that has been prepared specifically for mass spectrometry or any application where quantitative reproducibility is required. The solution has been prepared gravimetrically and is supplied in a deactivated glass ampule sealed under argon. The concentration was verified by comparison to an independently prepared calibration standard. This PGE2-EA MaxSpec® standard is guaranteed to meet identity, purity, stability, and concentration specifications and is provided with a batch-specific certificate of analysis. Ongoing stability testing is performed to ensure the concentration remains accurate throughout the shelf life of the product. Note: The amount of solution added to the vial is in excess of the listed amount. Therefore, it is necessary to accurately measure volumes for preparation of calibration standards. Follow recommended storage and handling conditions to maintain product quality.
Brand:CaymanSKU:10007212 - 100 µgAvailable on backorder
PGE2 is one of the primary COX products of arachidonic acid and one of the most widely investigated prostaglandins. Its activity influences inflammation, fertility and parturition, gastric mucosal integrity, and immune modulation.{1585,1558,437,1330} Because of its involvement in inflammation, PGE2 is the key indicator of non-steroidal anti-inflammatory drugs efficacy via inhibition of COX-1 and COX-2. Cayman Chemical’s PGE2 Express ELISA is a competitive assay that permits the rapid measurement of PGE2 from biological samples, requiring only 1 hour incubation and development times for each step. The foundation of the assay is Cayman’s high-affinity, well-characterized PGE2 monoclonal, the same used in our PGE2 Monoclonal ELISA kit (Item No. 514010). While Item No. 514010 offers superior sensitivity (80% B/B0 ~15 pg/ml), the new PGE2 Express Assay offers the convenience of a fast assay while still achieving an 80% B/B0 of 36 pg/ml and an assay range of 15.6-2,000 pg/ml.
Brand:CaymanSKU:500141 - 480 solid wellsAvailable on backorder
PGE2 is one of the primary COX products of arachidonic acid and one of the most widely investigated prostaglandins. Its activity influences inflammation, fertility and parturition, gastric mucosal integrity, and immune modulation.{1585,1558,437,1330} Because of its involvement in inflammation, PGE2 is the key indicator of non-steroidal anti-inflammatory drugs efficacy via inhibition of COX-1 and COX-2. Cayman Chemical’s PGE2 Express ELISA is a competitive assay that permits the rapid measurement of PGE2 from biological samples, requiring only 1 hour incubation and development times for each step. The foundation of the assay is Cayman’s high-affinity, well-characterized PGE2 monoclonal, the same used in our PGE2 Monoclonal ELISA kit (Item No. 514010). While Item No. 514010 offers superior sensitivity (80% B/B0 ~15 pg/ml), the new PGE2 Express Assay offers the convenience of a fast assay while still achieving an 80% B/B0 of 36 pg/ml and an assay range of 15.6-2,000 pg/ml.
Brand:CaymanSKU:500141 - 480 strip wellsAvailable on backorder
PGE2 is one of the primary COX products of arachidonic acid and one of the most widely investigated prostaglandins. Its activity influences inflammation, fertility and parturition, gastric mucosal integrity, and immune modulation.{1585,1558,437,1330} Because of its involvement in inflammation, PGE2 is the key indicator of non-steroidal anti-inflammatory drugs efficacy via inhibition of COX-1 and COX-2. Cayman Chemical’s PGE2 Express ELISA is a competitive assay that permits the rapid measurement of PGE2 from biological samples, requiring only 1 hour incubation and development times for each step. The foundation of the assay is Cayman’s high-affinity, well-characterized PGE2 monoclonal, the same used in our PGE2 Monoclonal ELISA kit (Item No. 514010). While Item No. 514010 offers superior sensitivity (80% B/B0 ~15 pg/ml), the new PGE2 Express Assay offers the convenience of a fast assay while still achieving an 80% B/B0 of 36 pg/ml and an assay range of 15.6-2,000 pg/ml.
Brand:CaymanSKU:500141 - 96 solid wellsAvailable on backorder
PGE2 is one of the primary COX products of arachidonic acid and one of the most widely investigated prostaglandins. Its activity influences inflammation, fertility and parturition, gastric mucosal integrity, and immune modulation.{1585,1558,437,1330} Because of its involvement in inflammation, PGE2 is the key indicator of non-steroidal anti-inflammatory drugs efficacy via inhibition of COX-1 and COX-2. Cayman Chemical’s PGE2 Express ELISA is a competitive assay that permits the rapid measurement of PGE2 from biological samples, requiring only 1 hour incubation and development times for each step. The foundation of the assay is Cayman’s high-affinity, well-characterized PGE2 monoclonal, the same used in our PGE2 Monoclonal ELISA kit (Item No. 514010). While Item No. 514010 offers superior sensitivity (80% B/B0 ~15 pg/ml), the new PGE2 Express Assay offers the convenience of a fast assay while still achieving an 80% B/B0 of 36 pg/ml and an assay range of 15.6-2,000 pg/ml.
Brand:CaymanSKU:500141 - 96 strip wellsAvailable on backorder
Brand:CaymanSKU:400144 - 1 eaAvailable on backorder
Prostaglandin E2 (PGE2) isopropyl ester is a more lipophilic form of the free acid, PGE2. PG esters have enhanced lipid solubility compared to their parent compounds. They are generally hydrolyzed to the free acid by endogenous esterases upon in vivo administration, making the esters useful prodrugs. In general, the C-1 esters of PGs show greatly diminished receptor activity in vitro compared to the parent free acids.
Brand:CaymanSKU:10384 - 1 mgAvailable on backorder
Prostaglandin E2 (PGE2) isopropyl ester is a more lipophilic form of the free acid, PGE2. PG esters have enhanced lipid solubility compared to their parent compounds. They are generally hydrolyzed to the free acid by endogenous esterases upon in vivo administration, making the esters useful prodrugs. In general, the C-1 esters of PGs show greatly diminished receptor activity in vitro compared to the parent free acids.
Brand:CaymanSKU:10384 - 10 mgAvailable on backorder
Prostaglandin E2 (PGE2) isopropyl ester is a more lipophilic form of the free acid, PGE2. PG esters have enhanced lipid solubility compared to their parent compounds. They are generally hydrolyzed to the free acid by endogenous esterases upon in vivo administration, making the esters useful prodrugs. In general, the C-1 esters of PGs show greatly diminished receptor activity in vitro compared to the parent free acids.
Brand:CaymanSKU:10384 - 5 mgAvailable on backorder
Prostaglandin E2 (PGE2) is one of the primary COX products of arachidonic acid (Item No. 90010) and one of the most widely investigated PGs. Its activity influences inflammation, fertility and parturition, gastric mucosal integrity, and immune modulation.{1585,1558,437,1330} The effects of PGE2 are transduced by at least four distinct receptors designated EP1, EP2, EP3, and EP4.{1422} Affinity constants (Kd) of PGE2 for these receptors range from 1-10 nM depending on the receptor subtype and tissue. PGE2 MaxSpec® standard is a quantitative grade standard of PGE2 (Item No. 14010) that has been prepared specifically for mass spectrometry or any application where quantitative reproducibility is required. The solution has been prepared gravimetrically and is supplied in a deactivated glass ampule sealed under argon. The concentration was verified by comparison to an independently prepared calibration standard. This PGE2 MaxSpec® standard is guaranteed to meet identity, purity, stability, and concentration specifications and is provided with a batch-specific certificate of analysis. Ongoing stability testing is performed to ensure the concentration remains accurate throughout the shelf life of the product. Note: The amount of solution added to the vial is in excess of the listed amount. Therefore, it is necessary to accurately measure volumes for preparation of calibration standards. Follow recommended storage and handling conditions to maintain product quality.
Brand:CaymanSKU:10007211 - 100 µgAvailable on backorder
Prostaglandin E2 methyl ester (PGE2 methyl ester) is an analog of PGE2 (Item No. 14010) with enhanced lipid solubility. PGE2 is one of the primary cyclooxygenase products of arachidonic acid (Item No. 90010) and one of the most widely investigated PGs. Its activity influences inflammation, fertility and parturition, gastric mucosal integrity, and immune modulation.{1585,1558,437,1330} The effects of PGE2 are transduced by at least four distinct receptors designated EP1, EP2, EP3, and EP4.{1422} Affinity constants (Kd) values of PGE2 for these receptors range from 1-10 nM depending on the receptor subtype and tissue.{1422}
Brand:CaymanSKU:- Prostaglandin E2 methyl ester (PGE2 methyl ester) is an analog of PGE2 (Item No. 14010) with enhanced lipid solubility. PGE2 is one of the primary cyclooxygenase products of arachidonic acid (Item No. 90010) and one of the most widely investigated PGs. Its activity influences inflammation, fertility and parturition, gastric mucosal integrity, and immune modulation.{1585,1558,437,1330} The effects of PGE2 are transduced by at least four distinct receptors designated EP1, EP2, EP3, and EP4.{1422} Affinity constants (Kd) values of PGE2 for these receptors range from 1-10 nM depending on the receptor subtype and tissue.{1422}
Brand:CaymanSKU:- Prostaglandin E2 methyl ester (PGE2 methyl ester) is an analog of PGE2 (Item No. 14010) with enhanced lipid solubility. PGE2 is one of the primary cyclooxygenase products of arachidonic acid (Item No. 90010) and one of the most widely investigated PGs. Its activity influences inflammation, fertility and parturition, gastric mucosal integrity, and immune modulation.{1585,1558,437,1330} The effects of PGE2 are transduced by at least four distinct receptors designated EP1, EP2, EP3, and EP4.{1422} Affinity constants (Kd) values of PGE2 for these receptors range from 1-10 nM depending on the receptor subtype and tissue.{1422}
Brand:CaymanSKU:- Prostaglandin E2 methyl ester (PGE2 methyl ester) is an analog of PGE2 (Item No. 14010) with enhanced lipid solubility. PGE2 is one of the primary cyclooxygenase products of arachidonic acid (Item No. 90010) and one of the most widely investigated PGs. Its activity influences inflammation, fertility and parturition, gastric mucosal integrity, and immune modulation.{1585,1558,437,1330} The effects of PGE2 are transduced by at least four distinct receptors designated EP1, EP2, EP3, and EP4.{1422} Affinity constants (Kd) values of PGE2 for these receptors range from 1-10 nM depending on the receptor subtype and tissue.{1422}
Brand:CaymanSKU:-
PGE2 p-acetamidophenyl ester is a crystalline derivative of PGE2. PGE2 is one of the primary COX products of arachidonic acid and one of the most widely investigated prostaglandins. Its activity influences inflammation, fertility and parturition, gastric mucosal integrity, and immune modulation.{1585,1558,437,1330} The effects of PGE2 are transduced by at least four distinct receptors designated EP1, EP2, EP3, and EP4.{1422} Affinity constants (Kd) of PGE2 for these receptors range from 1-10 nM depending on the receptor subtype and tissue.
Brand:CaymanSKU:- PGE2 p-acetamidophenyl ester is a crystalline derivative of PGE2. PGE2 is one of the primary COX products of arachidonic acid and one of the most widely investigated prostaglandins. Its activity influences inflammation, fertility and parturition, gastric mucosal integrity, and immune modulation.{1585,1558,437,1330} The effects of PGE2 are transduced by at least four distinct receptors designated EP1, EP2, EP3, and EP4.{1422} Affinity constants (Kd) of PGE2 for these receptors range from 1-10 nM depending on the receptor subtype and tissue.
Brand:CaymanSKU:- PGE2 p-acetamidophenyl ester is a crystalline derivative of PGE2. PGE2 is one of the primary COX products of arachidonic acid and one of the most widely investigated prostaglandins. Its activity influences inflammation, fertility and parturition, gastric mucosal integrity, and immune modulation.{1585,1558,437,1330} The effects of PGE2 are transduced by at least four distinct receptors designated EP1, EP2, EP3, and EP4.{1422} Affinity constants (Kd) of PGE2 for these receptors range from 1-10 nM depending on the receptor subtype and tissue.
Brand:CaymanSKU:-
PGE2 p-benzamidophenyl ester is a crystalline derivative of PGE2. PGE2 is one of the primary COX products of arachidonic acid and one of the most widely investigated prostaglandins. Its activity influences inflammation, fertility and parturition, gastric mucosal integrity, and immune modulation.{1585,1558,437,1330} The effects of PGE2 are transduced by at least four distinct receptors designated EP1, EP2, EP3, and EP4.{1422} Affinity constants (Kd) of PGE2 for these receptors range from 1-10 nM depending on the receptor subtype and tissue.
Brand:CaymanSKU:- PGE2 p-benzamidophenyl ester is a crystalline derivative of PGE2. PGE2 is one of the primary COX products of arachidonic acid and one of the most widely investigated prostaglandins. Its activity influences inflammation, fertility and parturition, gastric mucosal integrity, and immune modulation.{1585,1558,437,1330} The effects of PGE2 are transduced by at least four distinct receptors designated EP1, EP2, EP3, and EP4.{1422} Affinity constants (Kd) of PGE2 for these receptors range from 1-10 nM depending on the receptor subtype and tissue.
Brand:CaymanSKU:- PGE2 p-benzamidophenyl ester is a crystalline derivative of PGE2. PGE2 is one of the primary COX products of arachidonic acid and one of the most widely investigated prostaglandins. Its activity influences inflammation, fertility and parturition, gastric mucosal integrity, and immune modulation.{1585,1558,437,1330} The effects of PGE2 are transduced by at least four distinct receptors designated EP1, EP2, EP3, and EP4.{1422} Affinity constants (Kd) of PGE2 for these receptors range from 1-10 nM depending on the receptor subtype and tissue.
Brand:CaymanSKU:-
2-Arachidonyl glycerol (2-AG) exhibits cannabinoid agonist activity at the CB1 receptor, is an important endogenous monoglyceride species, and is thus considered to be the natural ligand for the CB1 receptor.{5306,6819} 2-AG can also be metabolized sequentially by COX-2 and specific prostaglandin (PG) synthases to form PG 2-glyceryl esters.{11045} PGE2-SA is a stable analog of PGE2 2-glyceryl ester. The biological activity of PGE2-SA has not yet been determined.
Brand:CaymanSKU:10193 - 1 mgAvailable on backorder
2-Arachidonyl glycerol (2-AG) exhibits cannabinoid agonist activity at the CB1 receptor, is an important endogenous monoglyceride species, and is thus considered to be the natural ligand for the CB1 receptor.{5306,6819} 2-AG can also be metabolized sequentially by COX-2 and specific prostaglandin (PG) synthases to form PG 2-glyceryl esters.{11045} PGE2-SA is a stable analog of PGE2 2-glyceryl ester. The biological activity of PGE2-SA has not yet been determined.
Brand:CaymanSKU:10193 - 10 mgAvailable on backorder
2-Arachidonyl glycerol (2-AG) exhibits cannabinoid agonist activity at the CB1 receptor, is an important endogenous monoglyceride species, and is thus considered to be the natural ligand for the CB1 receptor.{5306,6819} 2-AG can also be metabolized sequentially by COX-2 and specific prostaglandin (PG) synthases to form PG 2-glyceryl esters.{11045} PGE2-SA is a stable analog of PGE2 2-glyceryl ester. The biological activity of PGE2-SA has not yet been determined.
Brand:CaymanSKU:10193 - 5 mgAvailable on backorder
2-Arachidonyl glycerol (2-AG) exhibits cannabinoid agonist activity at the CB1 receptor, is an important endogenous monoglyceride species, and is thus considered to be the natural ligand for the CB1 receptor.{5306,6819} 2-AG can also be metabolized sequentially by COX-2 and specific prostaglandin (PG) synthases to form PG 2-glyceryl esters.{11045} PGE2-SA is a stable analog of PGE2 2-glyceryl ester. The biological activity of PGE2-SA has not yet been determined.
Brand:CaymanSKU:10193 - 500 µgAvailable on backorder
2-Arachidonoyl glycerol (2-AG; Item No. 62160) has been isolated from porcine brain, and has been characterized as the natural endocannabinoid ligand for the CB1 receptor.{4614,5306} Incubation of 2-AG with cyclooxygenase-2 and specific prostaglandin H2 (PGH2) isomerases in cell cultures and isolated enzyme preparations results in prostaglandin glycerol ester formation.{11045} The biosynthesis of PGH, PGD, PGE, PGF, and Thromboxane A-2-glyceryl ester compounds have all been documented. The 2-glyceryl ester moiety equilibrates rapidly (within minutes) with the more stable 1-glyceryl ester, producing a 10:90 2:1-glyceryl ester mixture in typical aqueous media. While the stability and metabolism of these prostaglandin products has been investigated, little is known about their intrinsic biological activity.{10555}
Brand:CaymanSKU:10140 - 1 mgAvailable on backorder
2-Arachidonoyl glycerol (2-AG; Item No. 62160) has been isolated from porcine brain, and has been characterized as the natural endocannabinoid ligand for the CB1 receptor.{4614,5306} Incubation of 2-AG with cyclooxygenase-2 and specific prostaglandin H2 (PGH2) isomerases in cell cultures and isolated enzyme preparations results in prostaglandin glycerol ester formation.{11045} The biosynthesis of PGH, PGD, PGE, PGF, and Thromboxane A-2-glyceryl ester compounds have all been documented. The 2-glyceryl ester moiety equilibrates rapidly (within minutes) with the more stable 1-glyceryl ester, producing a 10:90 2:1-glyceryl ester mixture in typical aqueous media. While the stability and metabolism of these prostaglandin products has been investigated, little is known about their intrinsic biological activity.{10555}
Brand:CaymanSKU:10140 - 10 mgAvailable on backorder
2-Arachidonoyl glycerol (2-AG; Item No. 62160) has been isolated from porcine brain, and has been characterized as the natural endocannabinoid ligand for the CB1 receptor.{4614,5306} Incubation of 2-AG with cyclooxygenase-2 and specific prostaglandin H2 (PGH2) isomerases in cell cultures and isolated enzyme preparations results in prostaglandin glycerol ester formation.{11045} The biosynthesis of PGH, PGD, PGE, PGF, and Thromboxane A-2-glyceryl ester compounds have all been documented. The 2-glyceryl ester moiety equilibrates rapidly (within minutes) with the more stable 1-glyceryl ester, producing a 10:90 2:1-glyceryl ester mixture in typical aqueous media. While the stability and metabolism of these prostaglandin products has been investigated, little is known about their intrinsic biological activity.{10555}
Brand:CaymanSKU:10140 - 5 mgAvailable on backorder
Prostaglandin E2-d4 (PGE2-d4) contains four deuterium atoms at the 3, 3′, 4, and 4′ positions. It is intended for use as an internal standard for the quantification of PGE2 by GC- or LC-mass spectrometry. PGE2 is one of the primary cyclooxygenase products of arachidonic acid and one of the most widely investigated prostaglandins. Its activity influences inflammation, fertility and parturition, gastric mucosal integrity, and immune modulation.{1585,1558,437,1330} The effects of PGE2 are transduced by at least four distinct receptors designated EP1, EP2, EP3, and EP4.{1422} The affinity constants (Kd) of PGE2 for these receptors range from 1-10 nM depending on the receptor subtype and tissue.
Brand:CaymanSKU:314010 - 100 µgAvailable on backorder
Prostaglandin E2-d4 (PGE2-d4) contains four deuterium atoms at the 3, 3′, 4, and 4′ positions. It is intended for use as an internal standard for the quantification of PGE2 by GC- or LC-mass spectrometry. PGE2 is one of the primary cyclooxygenase products of arachidonic acid and one of the most widely investigated prostaglandins. Its activity influences inflammation, fertility and parturition, gastric mucosal integrity, and immune modulation.{1585,1558,437,1330} The effects of PGE2 are transduced by at least four distinct receptors designated EP1, EP2, EP3, and EP4.{1422} The affinity constants (Kd) of PGE2 for these receptors range from 1-10 nM depending on the receptor subtype and tissue.
Brand:CaymanSKU:314010 - 50 µgAvailable on backorder
Prostaglandin E2-d4 (PGE2-d4) contains four deuterium atoms at the 3, 3′, 4, and 4′ positions. It is intended for use as an internal standard for the quantification of PGE2 by GC- or LC-mass spectrometry. PGE2 is one of the primary cyclooxygenase products of arachidonic acid and one of the most widely investigated prostaglandins. Its activity influences inflammation, fertility and parturition, gastric mucosal integrity, and immune modulation.{1585,1558,437,1330} The effects of PGE2 are transduced by at least four distinct receptors designated EP1, EP2, EP3, and EP4.{1422} The affinity constants (Kd) of PGE2 for these receptors range from 1-10 nM depending on the receptor subtype and tissue.
Brand:CaymanSKU:314010 - 500 µgAvailable on backorder
PGE2-d9 contains nine deuterium atoms at the 17, 17’, 18, 18’, 19, 19′, 20, 20, and 20′ positions. It is intended for use as an internal standard for the quantification of PGE2 by GC- or LC-mass spectrometry (MS). PGE2 is one of the primary cyclooxygenase products of arachidonic acid and one of the most widely investigated prostaglandins. Its activity influences inflammation, fertility and parturition, gastric mucosal integrity, and immune modulation.{1585,1558,437,1330} The effects of PGE2 are transduced by at least four distinct receptors designated EP1, EP2, EP3, and EP4.{1422} Affinity constants (Kd) of PGE2 for these receptors range from 1-10 nM depending on the receptor subtype and tissue.
Brand:CaymanSKU:10581 - 100 µgAvailable on backorder
PGE2-d9 contains nine deuterium atoms at the 17, 17’, 18, 18’, 19, 19′, 20, 20, and 20′ positions. It is intended for use as an internal standard for the quantification of PGE2 by GC- or LC-mass spectrometry (MS). PGE2 is one of the primary cyclooxygenase products of arachidonic acid and one of the most widely investigated prostaglandins. Its activity influences inflammation, fertility and parturition, gastric mucosal integrity, and immune modulation.{1585,1558,437,1330} The effects of PGE2 are transduced by at least four distinct receptors designated EP1, EP2, EP3, and EP4.{1422} Affinity constants (Kd) of PGE2 for these receptors range from 1-10 nM depending on the receptor subtype and tissue.
Brand:CaymanSKU:10581 - 250 µgAvailable on backorder
PGE2-d9 contains nine deuterium atoms at the 17, 17’, 18, 18’, 19, 19′, 20, 20, and 20′ positions. It is intended for use as an internal standard for the quantification of PGE2 by GC- or LC-mass spectrometry (MS). PGE2 is one of the primary cyclooxygenase products of arachidonic acid and one of the most widely investigated prostaglandins. Its activity influences inflammation, fertility and parturition, gastric mucosal integrity, and immune modulation.{1585,1558,437,1330} The effects of PGE2 are transduced by at least four distinct receptors designated EP1, EP2, EP3, and EP4.{1422} Affinity constants (Kd) of PGE2 for these receptors range from 1-10 nM depending on the receptor subtype and tissue.
Brand:CaymanSKU:10581 - 50 µgAvailable on backorder
PGE2-d9 contains nine deuterium atoms at the 17, 17’, 18, 18’, 19, 19′, 20, 20, and 20′ positions. It is intended for use as an internal standard for the quantification of PGE2 by GC- or LC-mass spectrometry (MS). PGE2 is one of the primary cyclooxygenase products of arachidonic acid and one of the most widely investigated prostaglandins. Its activity influences inflammation, fertility and parturition, gastric mucosal integrity, and immune modulation.{1585,1558,437,1330} The effects of PGE2 are transduced by at least four distinct receptors designated EP1, EP2, EP3, and EP4.{1422} Affinity constants (Kd) of PGE2 for these receptors range from 1-10 nM depending on the receptor subtype and tissue.
Brand:CaymanSKU:10581 - 500 µgAvailable on backorder
Prostaglandin E3 (PGE3) is formed via the cyclooxygenase (COX) metabolism of eicosapentaenoic acid.{1145} In human ocular tissue, it comprises 2.4% of the COX products formed.{1145} When applied to the eyes of a rabbit, a 1 µg dose of PGE3 decreases intraocular pressure from 21 mmHg to about 17 mmHg.{1225}
Brand:CaymanSKU:- Prostaglandin E3 (PGE3) is formed via the cyclooxygenase (COX) metabolism of eicosapentaenoic acid.{1145} In human ocular tissue, it comprises 2.4% of the COX products formed.{1145} When applied to the eyes of a rabbit, a 1 µg dose of PGE3 decreases intraocular pressure from 21 mmHg to about 17 mmHg.{1225}
Brand:CaymanSKU:- Prostaglandin E3 (PGE3) is formed via the cyclooxygenase (COX) metabolism of eicosapentaenoic acid.{1145} In human ocular tissue, it comprises 2.4% of the COX products formed.{1145} When applied to the eyes of a rabbit, a 1 µg dose of PGE3 decreases intraocular pressure from 21 mmHg to about 17 mmHg.{1225}
Brand:CaymanSKU:- Prostaglandin E3 (PGE3) is formed via the cyclooxygenase (COX) metabolism of eicosapentaenoic acid.{1145} In human ocular tissue, it comprises 2.4% of the COX products formed.{1145} When applied to the eyes of a rabbit, a 1 µg dose of PGE3 decreases intraocular pressure from 21 mmHg to about 17 mmHg.{1225}
Brand:CaymanSKU:-
Prostaglandin F2α (PGF2α) is a biologically important prostanoid that exerts its actions through binding to the PGF2α receptor (FP).{50204} PGF2α is synthesized in many tissues, including the eye and organs of the female reproductive system. Activation of ocular FP receptors via agonists such as bimatoprost and travoprost reduces ocular hypertension.{9311,8839} Antagonism of the FP receptor inhibits uterine contraction and delays parturition in rodent models, while knockout of the receptor inhibits parturition in mice, an effect that can be restored through ovariectomy during pregnancy.{50205,4688} FP receptor antagonism also decreases endometriosis-like lesions and reduces cell proliferation and angiogenesis in a nude mouse endometrial xenograft model.{50206} In addition, FP receptor knockout increases neurological deficits and lesion volume in mice following intracerebral hemorrhagic stroke.{50207} These findings highlight the importance of the FP receptor in reproductive and neurological disorders and emphasize the need for continued research and drug discovery in these areas.
Brand:CaymanSKU:601800 - 1 eaAvailable on backorder
Prostaglandin F1α (PGF1α) is the putative metabolite of dihomo-γ-linolenic acid (DGLA) via the cyclooxygenase (COX) pathway. Both PGF1α and PGF2α (Item Nos. 16010 | 10007221) have been shown to act as priming pheromones for male Atlantic salmon with a threshold concentration of 10−11 M.{3467} PGF1α binds to the ovine corpus luteum FP receptor at only 8% of the relative potency of PGF2α.{2058} It is only half as active as PGF2α in inducing human respiratory smooth muscle contractions in vitro.{2218}
Brand:CaymanSKU:- Prostaglandin F1α (PGF1α) is the putative metabolite of dihomo-γ-linolenic acid (DGLA) via the cyclooxygenase (COX) pathway. Both PGF1α and PGF2α (Item Nos. 16010 | 10007221) have been shown to act as priming pheromones for male Atlantic salmon with a threshold concentration of 10−11 M.{3467} PGF1α binds to the ovine corpus luteum FP receptor at only 8% of the relative potency of PGF2α.{2058} It is only half as active as PGF2α in inducing human respiratory smooth muscle contractions in vitro.{2218}
Brand:CaymanSKU:- Prostaglandin F1α (PGF1α) is the putative metabolite of dihomo-γ-linolenic acid (DGLA) via the cyclooxygenase (COX) pathway. Both PGF1α and PGF2α (Item Nos. 16010 | 10007221) have been shown to act as priming pheromones for male Atlantic salmon with a threshold concentration of 10−11 M.{3467} PGF1α binds to the ovine corpus luteum FP receptor at only 8% of the relative potency of PGF2α.{2058} It is only half as active as PGF2α in inducing human respiratory smooth muscle contractions in vitro.{2218}
Brand:CaymanSKU:-
Prostaglandin F1α (PGF1α) alcohol is an analog of PGF1α with a primary alcohol replacing the C-1 carboxyl group. There are no published reports on the biological activity of this compound; however, the corresponding PGE1 analog (Item No. 13020) is a relatively selective EP3 and EP4 receptor ligand.{6640}
Brand:CaymanSKU:-