Cayman
Showing 36001–36150 of 45550 results
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Probenecid (Item No. 26294) is an analytical reference standard categorized as a masking agent in sports doping.{51147} It has been detected as an adverse analytical finding (AAF) during anti-doping testing.{48164} This product is intended for use in analytical forensic applications. This product is also available as a general research tool (Item No. 14981).
Brand:CaymanSKU:26294 - 5 mgAvailable on backorder
Probenecid-d14 is intended for use as an internal standard for the quantification of probenecid (Item No. 14981) by GC- or LC-MS. Probenecid is a benzoic acid derivative that inhibits organic anion transporters (OATs) but activates the transient receptor potential (TRP) channel TRPV2. It inhibits OAT1, OAT3, and OAT6 with Ki values of 6.3, 9.0, and 8.4 µM, respectively, as well as OAT2 with an IC50 value of 0.67 µM.{23928,23931,23929} It is a poor inhibitor of the organic cation transporters OCT1 and OCT2 (IC50 = 1.6 and 1.7 mM, respectively).{23932} It also acts as an agonist of TRPV2 (EC50 = 31.9 µM), eliciting nociceptive behavior under inflammatory conditions in mice. Formulations containing probenecid have been used in the treatment of gouty arthritis.{23933}
Brand:CaymanSKU:26787 - 1 mgAvailable on backorder
Probenecid-d14 is intended for use as an internal standard for the quantification of probenecid (Item No. 14981) by GC- or LC-MS. Probenecid is a benzoic acid derivative that inhibits organic anion transporters (OATs) but activates the transient receptor potential (TRP) channel TRPV2. It inhibits OAT1, OAT3, and OAT6 with Ki values of 6.3, 9.0, and 8.4 µM, respectively, as well as OAT2 with an IC50 value of 0.67 µM.{23928,23931,23929} It is a poor inhibitor of the organic cation transporters OCT1 and OCT2 (IC50 = 1.6 and 1.7 mM, respectively).{23932} It also acts as an agonist of TRPV2 (EC50 = 31.9 µM), eliciting nociceptive behavior under inflammatory conditions in mice. Formulations containing probenecid have been used in the treatment of gouty arthritis.{23933}
Brand:CaymanSKU:26787 - 5 mgAvailable on backorder
Probucol is a potent antioxidant that inhibits the oxidation of cholesterol in LDL, which prevents the formation of macrophage-derived foam cells that lead to atherosclerotic vascular lesions.{24123} Probucol’s use is limited, however, because it leads to the reduction of HDL cholesterol as well.{24123} Probucol inhibits up to 80% efflux of cholesterol from J774 macrophages by impairing the translocation of ATP-binding cassette transporter A1 from intracellular compartments to the plasma membrane.{24125} In an in vivo mouse model of Huntington’s disease, 3.5 mg/kg/day probucol was shown to be protective against behavioral and striatal oxidative damage by increasing the activity of glutathione peroxidase.{24124}
Brand:CaymanSKU:- Probucol is a potent antioxidant that inhibits the oxidation of cholesterol in LDL, which prevents the formation of macrophage-derived foam cells that lead to atherosclerotic vascular lesions.{24123} Probucol’s use is limited, however, because it leads to the reduction of HDL cholesterol as well.{24123} Probucol inhibits up to 80% efflux of cholesterol from J774 macrophages by impairing the translocation of ATP-binding cassette transporter A1 from intracellular compartments to the plasma membrane.{24125} In an in vivo mouse model of Huntington’s disease, 3.5 mg/kg/day probucol was shown to be protective against behavioral and striatal oxidative damage by increasing the activity of glutathione peroxidase.{24124}
Brand:CaymanSKU:- Probucol is a potent antioxidant that inhibits the oxidation of cholesterol in LDL, which prevents the formation of macrophage-derived foam cells that lead to atherosclerotic vascular lesions.{24123} Probucol’s use is limited, however, because it leads to the reduction of HDL cholesterol as well.{24123} Probucol inhibits up to 80% efflux of cholesterol from J774 macrophages by impairing the translocation of ATP-binding cassette transporter A1 from intracellular compartments to the plasma membrane.{24125} In an in vivo mouse model of Huntington’s disease, 3.5 mg/kg/day probucol was shown to be protective against behavioral and striatal oxidative damage by increasing the activity of glutathione peroxidase.{24124}
Brand:CaymanSKU:- Probucol is a potent antioxidant that inhibits the oxidation of cholesterol in LDL, which prevents the formation of macrophage-derived foam cells that lead to atherosclerotic vascular lesions.{24123} Probucol’s use is limited, however, because it leads to the reduction of HDL cholesterol as well.{24123} Probucol inhibits up to 80% efflux of cholesterol from J774 macrophages by impairing the translocation of ATP-binding cassette transporter A1 from intracellular compartments to the plasma membrane.{24125} In an in vivo mouse model of Huntington’s disease, 3.5 mg/kg/day probucol was shown to be protective against behavioral and striatal oxidative damage by increasing the activity of glutathione peroxidase.{24124}
Brand:CaymanSKU:-
Procainamide (hydrochloride) (Item No. 24359) is an analytical reference standard categorized as a local anesthetic.{39459} This product is intended for research and forensic applications.
Brand:CaymanSKU:24359 - 1 mgAvailable on backorder
Procainamide (hydrochloride) (Item No. 24359) is an analytical reference standard categorized as a local anesthetic.{39459} This product is intended for research and forensic applications.
Brand:CaymanSKU:24359 - 5 mgAvailable on backorder
Procaine (hydrochloride) (Item No. 20093) is an analytical reference standard categorized as a local anesthetic that is used as an adulterant. Procaine blocks sodium channels, and formulations containing procaine are used to prevent or relieve pain for short periods, such as during dental procedures.{34499} It is commonly found as an adulterant in illicit drugs.{31809} This product is intended for research and forensic applications.
Brand:CaymanSKU:20093 -Available on backorder
Procaine (hydrochloride) (Item No. 20093) is an analytical reference standard categorized as a local anesthetic that is used as an adulterant. Procaine blocks sodium channels, and formulations containing procaine are used to prevent or relieve pain for short periods, such as during dental procedures.{34499} It is commonly found as an adulterant in illicit drugs.{31809} This product is intended for research and forensic applications.
Brand:CaymanSKU:20093 -Available on backorder
Procarbazine is a methyl hydrazine derivative that is converted by metabolism into a methylating species which converts DNA to various DNA adducts, including O6-methylguanine.{26359} While this process is mutagenic and carcinogenic, procarbazine is used with the compounds mechlorethamine, vincristine, also known as oncovin (Item No. 11764), and prednisone as part of the MOPP regimen for fighting Hodgkin disease.{26359,26357,26358} Procarbazine also has utility, in combination with other agents, in reducing the frequency of epileptic seizures in patients with pharmacoresistant epilepsy.{26360}
Brand:CaymanSKU:- Procarbazine is a methyl hydrazine derivative that is converted by metabolism into a methylating species which converts DNA to various DNA adducts, including O6-methylguanine.{26359} While this process is mutagenic and carcinogenic, procarbazine is used with the compounds mechlorethamine, vincristine, also known as oncovin (Item No. 11764), and prednisone as part of the MOPP regimen for fighting Hodgkin disease.{26359,26357,26358} Procarbazine also has utility, in combination with other agents, in reducing the frequency of epileptic seizures in patients with pharmacoresistant epilepsy.{26360}
Brand:CaymanSKU:- Procarbazine is a methyl hydrazine derivative that is converted by metabolism into a methylating species which converts DNA to various DNA adducts, including O6-methylguanine.{26359} While this process is mutagenic and carcinogenic, procarbazine is used with the compounds mechlorethamine, vincristine, also known as oncovin (Item No. 11764), and prednisone as part of the MOPP regimen for fighting Hodgkin disease.{26359,26357,26358} Procarbazine also has utility, in combination with other agents, in reducing the frequency of epileptic seizures in patients with pharmacoresistant epilepsy.{26360}
Brand:CaymanSKU:- Procarbazine is a methyl hydrazine derivative that is converted by metabolism into a methylating species which converts DNA to various DNA adducts, including O6-methylguanine.{26359} While this process is mutagenic and carcinogenic, procarbazine is used with the compounds mechlorethamine, vincristine, also known as oncovin (Item No. 11764), and prednisone as part of the MOPP regimen for fighting Hodgkin disease.{26359,26357,26358} Procarbazine also has utility, in combination with other agents, in reducing the frequency of epileptic seizures in patients with pharmacoresistant epilepsy.{26360}
Brand:CaymanSKU:-
Procaterol is an agonist of β2-adrenergic receptors (β2-ARs).{47634} It binds to (Kd = 46 pM), and is selective for, β2-ARs over β1-ARs (Kd = 4,000 pM). Procaterol binds more potently to β2-ARs in isolated guinea pig lung than to β1-ARs in isolated guinea pig cardiac ventricle in the presence (IC50s = 175 and 1,660 nM, respectively) and absence of GTP (Item No. 16060; IC50s = 55.1 and 1,660 nM, respectively).{47635} It inhibits contractions induced by acetylcholine (Item No. 23829) in isolated guinea pig trachea (EC50 = 10.5 nM).{47636} In vivo, procaterol inhibits histamine-induced airflow obstruction in a guinea pig model of ovalbumin-sensitized asthma when administered via inhalation at a dose of 10 µg/ml.{47637}
Brand:CaymanSKU:28479 - 10 mgAvailable on backorder
Procaterol is an agonist of β2-adrenergic receptors (β2-ARs).{47634} It binds to (Kd = 46 pM), and is selective for, β2-ARs over β1-ARs (Kd = 4,000 pM). Procaterol binds more potently to β2-ARs in isolated guinea pig lung than to β1-ARs in isolated guinea pig cardiac ventricle in the presence (IC50s = 175 and 1,660 nM, respectively) and absence of GTP (Item No. 16060; IC50s = 55.1 and 1,660 nM, respectively).{47635} It inhibits contractions induced by acetylcholine (Item No. 23829) in isolated guinea pig trachea (EC50 = 10.5 nM).{47636} In vivo, procaterol inhibits histamine-induced airflow obstruction in a guinea pig model of ovalbumin-sensitized asthma when administered via inhalation at a dose of 10 µg/ml.{47637}
Brand:CaymanSKU:28479 - 25 mgAvailable on backorder
Procaterol is an agonist of β2-adrenergic receptors (β2-ARs).{47634} It binds to (Kd = 46 pM), and is selective for, β2-ARs over β1-ARs (Kd = 4,000 pM). Procaterol binds more potently to β2-ARs in isolated guinea pig lung than to β1-ARs in isolated guinea pig cardiac ventricle in the presence (IC50s = 175 and 1,660 nM, respectively) and absence of GTP (Item No. 16060; IC50s = 55.1 and 1,660 nM, respectively).{47635} It inhibits contractions induced by acetylcholine (Item No. 23829) in isolated guinea pig trachea (EC50 = 10.5 nM).{47636} In vivo, procaterol inhibits histamine-induced airflow obstruction in a guinea pig model of ovalbumin-sensitized asthma when administered via inhalation at a dose of 10 µg/ml.{47637}
Brand:CaymanSKU:28479 - 5 mgAvailable on backorder
Procaterol is an agonist of β2-adrenergic receptors (β2-ARs).{47634} It binds to (Kd = 46 pM), and is selective for, β2-ARs over β1-ARs (Kd = 4,000 pM). Procaterol binds more potently to β2-ARs in isolated guinea pig lung than to β1-ARs in isolated guinea pig cardiac ventricle in the presence (IC50s = 175 and 1,660 nM, respectively) and absence of GTP (Item No. 16060; IC50s = 55.1 and 1,660 nM, respectively).{47635} It inhibits contractions induced by acetylcholine (Item No. 23829) in isolated guinea pig trachea (EC50 = 10.5 nM).{47636} In vivo, procaterol inhibits histamine-induced airflow obstruction in a guinea pig model of ovalbumin-sensitized asthma when administered via inhalation at a dose of 10 µg/ml.{47637}
Brand:CaymanSKU:28479 - 50 mgAvailable on backorder
Prochloraz is an imidazole antifungal that inhibits ergosterol biosynthesis via inhibition of the cytochrome P450-dependent 14α-demethylation of lanosterol, which results in disruption of the fungal cell membrane and cell death.{41691} It inhibits human placenta microsomal aromatase in vitro (IC50 = 40 nM).{30331} Prochloraz also acts as an antagonist of the estrogen receptor (ER) and androgen receptor (AR) (IC50s = 25 and 4 μM, respectively) as well as activates the aryl hydrocarbon receptor (AhR; EC50 = 1 μM).{41692} In vivo, prochloraz (250 mg/kg) reduces the weight of seminal vesicles in intact male rats and of seminal vesicles, ventral prostate, and bulbourethral glands in castrated testosterone-treated male rats.{41693} It also reduces testosterone levels and increases progesterone levels in male rat pups following administration of a 30 mg/kg per day dose to pregnant females during gestation. Formulations containing prochloraz have been used to control fungal growth in mushroom cultivation.
Brand:CaymanSKU:24051 - 100 mgAvailable on backorder
Prochlorperazine is a dopamine D2 receptor antagonist with Ki values of 4.7 and 2.9 nM for rat recombinant D2 receptors in CHO cells and rat striatal membranes, respectively.{30683,39858} It also binds to rat recombinant D3 receptors expressed in CHO cells (Ki = 35 nM) and to the serotonin (5-HT) receptor subtype 5-HT3 in N1E-115 mouse neuroblastoma cell membranes (Ki = 1,200 nM).{30683,39857} Prochlorperazine (2 mg/kg) increases the latency to paw licking in a hot plate test, indicating analgesia, an effect that is blocked by antisense oligonucleotides against the M1 muscarinic receptor.{39859} It also inhibits emesis induced by apomorphine (Item No. 16094) in dogs (ED50 = 0.34 mg/kg).{39860} Formulations containing prochlorperazine have been used in the treatment of psychotic disorders and as antiemetics.
Brand:CaymanSKU:20742 -Available on backorder
Prochlorperazine is a dopamine D2 receptor antagonist with Ki values of 4.7 and 2.9 nM for rat recombinant D2 receptors in CHO cells and rat striatal membranes, respectively.{30683,39858} It also binds to rat recombinant D3 receptors expressed in CHO cells (Ki = 35 nM) and to the serotonin (5-HT) receptor subtype 5-HT3 in N1E-115 mouse neuroblastoma cell membranes (Ki = 1,200 nM).{30683,39857} Prochlorperazine (2 mg/kg) increases the latency to paw licking in a hot plate test, indicating analgesia, an effect that is blocked by antisense oligonucleotides against the M1 muscarinic receptor.{39859} It also inhibits emesis induced by apomorphine (Item No. 16094) in dogs (ED50 = 0.34 mg/kg).{39860} Formulations containing prochlorperazine have been used in the treatment of psychotic disorders and as antiemetics.
Brand:CaymanSKU:20742 -Available on backorder
Prochlorperazine is a dopamine D2 receptor antagonist with Ki values of 4.7 and 2.9 nM for rat recombinant D2 receptors in CHO cells and rat striatal membranes, respectively.{30683,39858} It also binds to rat recombinant D3 receptors expressed in CHO cells (Ki = 35 nM) and to the serotonin (5-HT) receptor subtype 5-HT3 in N1E-115 mouse neuroblastoma cell membranes (Ki = 1,200 nM).{30683,39857} Prochlorperazine (2 mg/kg) increases the latency to paw licking in a hot plate test, indicating analgesia, an effect that is blocked by antisense oligonucleotides against the M1 muscarinic receptor.{39859} It also inhibits emesis induced by apomorphine (Item No. 16094) in dogs (ED50 = 0.34 mg/kg).{39860} Formulations containing prochlorperazine have been used in the treatment of psychotic disorders and as antiemetics.
Brand:CaymanSKU:20742 -Available on backorder
Prochlorperazine is a dopamine D2 receptor antagonist with Ki values of 4.7 and 2.9 nM for rat recombinant D2 receptors in CHO cells and rat striatal membranes, respectively.{30683,39858} It also binds to rat recombinant D3 receptors expressed in CHO cells (Ki = 35 nM) and to the serotonin (5-HT) receptor subtype 5-HT3 in N1E-115 mouse neuroblastoma cell membranes (Ki = 1,200 nM).{30683,39857} Prochlorperazine (2 mg/kg) increases the latency to paw licking in a hot plate test, indicating analgesia, an effect that is blocked by antisense oligonucleotides against the M1 muscarinic receptor.{39859} It also inhibits emesis induced by apomorphine (Item No. 16094) in dogs (ED50 = 0.34 mg/kg).{39860} Formulations containing prochlorperazine have been used in the treatment of psychotic disorders and as antiemetics.
Brand:CaymanSKU:20742 -Available on backorder
Procyanidin is a polyphenol that exhibits antioxidant activity in a macrocyclic nickel complex-catalyzed Briggs-Rauscher oscillation system.{54087}
Brand:CaymanSKU:29763 - 1 gAvailable on backorder
Procyanidin is a polyphenol that exhibits antioxidant activity in a macrocyclic nickel complex-catalyzed Briggs-Rauscher oscillation system.{54087}
Brand:CaymanSKU:29763 - 10 gAvailable on backorder
Procyanidin is a polyphenol that exhibits antioxidant activity in a macrocyclic nickel complex-catalyzed Briggs-Rauscher oscillation system.{54087}
Brand:CaymanSKU:29763 - 5 gAvailable on backorder
Procyanidin A2 is a natural flavanol dimer of (–)–epicatechin (Item No. 11807) that is found in the horse chestnut (A. hippocastanum), mountain cranberry (V. vitis-idaea), and other fruits with antioxidant, anti-inflammatory, antibacterial, antiproliferative, and antidiabetic properties.{39743,39744,39745,39746,39747} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals (IC50 = 5.08 μM) and inhibits STAT3 activation induced by platelet derived growth factor (PDGF) in primary rat vascular smooth muscle cells (VSMCs) when used at a concentration of 30 μg/ml.{39745,39746} Procyanidin A2 inhibits growth of S. aureus and E. coli (MICs = 62.5 and 62.5 μg/ml, respectively) and proliferation of human HepG2 liver hepatocellular carcinoma and HeLa cervical cancer cells (EC50s = 62.19 and 66.07 μg/ml, respectively).{39745} It also increases insulin secretion from primary mouse pancreatic islets when used at a concentration of 10 μM in vitro and inhibits bisphenol A-induced glucose increases in fasted mice when administered at a dose of 10 μmol/kg per day.{39747}
Brand:CaymanSKU:25200 - 1 mgAvailable on backorder
Procyanidin A2 is a natural flavanol dimer of (–)–epicatechin (Item No. 11807) that is found in the horse chestnut (A. hippocastanum), mountain cranberry (V. vitis-idaea), and other fruits with antioxidant, anti-inflammatory, antibacterial, antiproliferative, and antidiabetic properties.{39743,39744,39745,39746,39747} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals (IC50 = 5.08 μM) and inhibits STAT3 activation induced by platelet derived growth factor (PDGF) in primary rat vascular smooth muscle cells (VSMCs) when used at a concentration of 30 μg/ml.{39745,39746} Procyanidin A2 inhibits growth of S. aureus and E. coli (MICs = 62.5 and 62.5 μg/ml, respectively) and proliferation of human HepG2 liver hepatocellular carcinoma and HeLa cervical cancer cells (EC50s = 62.19 and 66.07 μg/ml, respectively).{39745} It also increases insulin secretion from primary mouse pancreatic islets when used at a concentration of 10 μM in vitro and inhibits bisphenol A-induced glucose increases in fasted mice when administered at a dose of 10 μmol/kg per day.{39747}
Brand:CaymanSKU:25200 - 10 mgAvailable on backorder
Procyanidin A2 is a natural flavanol dimer of (–)–epicatechin (Item No. 11807) that is found in the horse chestnut (A. hippocastanum), mountain cranberry (V. vitis-idaea), and other fruits with antioxidant, anti-inflammatory, antibacterial, antiproliferative, and antidiabetic properties.{39743,39744,39745,39746,39747} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals (IC50 = 5.08 μM) and inhibits STAT3 activation induced by platelet derived growth factor (PDGF) in primary rat vascular smooth muscle cells (VSMCs) when used at a concentration of 30 μg/ml.{39745,39746} Procyanidin A2 inhibits growth of S. aureus and E. coli (MICs = 62.5 and 62.5 μg/ml, respectively) and proliferation of human HepG2 liver hepatocellular carcinoma and HeLa cervical cancer cells (EC50s = 62.19 and 66.07 μg/ml, respectively).{39745} It also increases insulin secretion from primary mouse pancreatic islets when used at a concentration of 10 μM in vitro and inhibits bisphenol A-induced glucose increases in fasted mice when administered at a dose of 10 μmol/kg per day.{39747}
Brand:CaymanSKU:25200 - 5 mgAvailable on backorder
Procyanidin B1 is a polyphenol flavonoid existing as a dimer of (+)-catechin (Item No. 70940) and (−)-epicatechin (Item No. 11807). It inhibits hepatitis C virus RNA replication (EC50 = 72 µM), while (+)-catechin and (−)-epicatechin do not, up to concentrations of 200 µM.{34659} Procyanidin C1 (10 µg/ml) prevents phosphorylation of ERK1/2 and the production of reactive oxygen species (ROS) in THP-1 cells.{34660} It decreases TNF-α, phosphorylated p38 MAPK, and NF-κB levels following LPS administration.{34661}
Brand:CaymanSKU:22411 -Out of stock
Procyanidin B1 is a polyphenol flavonoid existing as a dimer of (+)-catechin (Item No. 70940) and (−)-epicatechin (Item No. 11807). It inhibits hepatitis C virus RNA replication (EC50 = 72 µM), while (+)-catechin and (−)-epicatechin do not, up to concentrations of 200 µM.{34659} Procyanidin C1 (10 µg/ml) prevents phosphorylation of ERK1/2 and the production of reactive oxygen species (ROS) in THP-1 cells.{34660} It decreases TNF-α, phosphorylated p38 MAPK, and NF-κB levels following LPS administration.{34661}
Brand:CaymanSKU:22411 -Out of stock
Procyanidin B1 is a polyphenol flavonoid existing as a dimer of (+)-catechin (Item No. 70940) and (−)-epicatechin (Item No. 11807). It inhibits hepatitis C virus RNA replication (EC50 = 72 µM), while (+)-catechin and (−)-epicatechin do not, up to concentrations of 200 µM.{34659} Procyanidin C1 (10 µg/ml) prevents phosphorylation of ERK1/2 and the production of reactive oxygen species (ROS) in THP-1 cells.{34660} It decreases TNF-α, phosphorylated p38 MAPK, and NF-κB levels following LPS administration.{34661}
Brand:CaymanSKU:22411 -Out of stock
Procyanidin B2 is a phenol and a dimer of (–)-epicatechin (Item No. 11807) that has been found in apple pomace and has diverse biological activities.{54438,54439,54440,54441} It inhibits MCF-7 breast cancer cell proliferation (IC50 = 19.2 µM).{54438} Procyanidin B2 scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) and superoxide anion radicals in cell-free assays.{54439} It inhibits LDL oxidation in vitro by 79.5 and 98% when used at concentrations of 5 and 10 µM, respectively.{54440} Procyanidin B2 (100 mg/kg) prevents carbon tetrachloride-induced increases in serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activities and hepatic injury in mice.{54441}
Brand:CaymanSKU:19865 -Available on backorder
Procyanidin B2 is a phenol and a dimer of (–)-epicatechin (Item No. 11807) that has been found in apple pomace and has diverse biological activities.{54438,54439,54440,54441} It inhibits MCF-7 breast cancer cell proliferation (IC50 = 19.2 µM).{54438} Procyanidin B2 scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) and superoxide anion radicals in cell-free assays.{54439} It inhibits LDL oxidation in vitro by 79.5 and 98% when used at concentrations of 5 and 10 µM, respectively.{54440} Procyanidin B2 (100 mg/kg) prevents carbon tetrachloride-induced increases in serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activities and hepatic injury in mice.{54441}
Brand:CaymanSKU:19865 -Available on backorder
Procyanidin B2 is a phenol and a dimer of (–)-epicatechin (Item No. 11807) that has been found in apple pomace and has diverse biological activities.{54438,54439,54440,54441} It inhibits MCF-7 breast cancer cell proliferation (IC50 = 19.2 µM).{54438} Procyanidin B2 scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) and superoxide anion radicals in cell-free assays.{54439} It inhibits LDL oxidation in vitro by 79.5 and 98% when used at concentrations of 5 and 10 µM, respectively.{54440} Procyanidin B2 (100 mg/kg) prevents carbon tetrachloride-induced increases in serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activities and hepatic injury in mice.{54441}
Brand:CaymanSKU:19865 -Available on backorder
Procyanidin B3 is a polyphenol flavonoid dimer of (+)-catechin (Item No. 70940) that has been found in G. biloba and has diverse biological activities.{27617,52199,52200} It inhibits aggregation of amyloid-β (1-42) (Aβ42; Item No. 20574) with an IC50 value of 3.54 μM and destabilizes preformed Aβ42 fibrils (EC50 = 5.12 μM).{27617} Procyanidin B3 (1 mM) reduces oxidation of linoleic acid and scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) free radicals in cell-free assays.{52199} It inhibits hydrogen peroxide-induced production of inducible nitric oxide synthase (iNOS) and apoptosis in primary murine chondrocytes.{52200} Procyanidin B3 (0.01 mg/kg) reduces chondrocyte apoptosis, pseudocapsule thickness, and the frequency of ectopic cartilage formation in a mouse model of surgically induced osteoarthritis.
Brand:CaymanSKU:29065 - 1 mgAvailable on backorder
Procyanidin B3 is a polyphenol flavonoid dimer of (+)-catechin (Item No. 70940) that has been found in G. biloba and has diverse biological activities.{27617,52199,52200} It inhibits aggregation of amyloid-β (1-42) (Aβ42; Item No. 20574) with an IC50 value of 3.54 μM and destabilizes preformed Aβ42 fibrils (EC50 = 5.12 μM).{27617} Procyanidin B3 (1 mM) reduces oxidation of linoleic acid and scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) free radicals in cell-free assays.{52199} It inhibits hydrogen peroxide-induced production of inducible nitric oxide synthase (iNOS) and apoptosis in primary murine chondrocytes.{52200} Procyanidin B3 (0.01 mg/kg) reduces chondrocyte apoptosis, pseudocapsule thickness, and the frequency of ectopic cartilage formation in a mouse model of surgically induced osteoarthritis.
Brand:CaymanSKU:29065 - 10 mgAvailable on backorder
Procyanidin B3 is a polyphenol flavonoid dimer of (+)-catechin (Item No. 70940) that has been found in G. biloba and has diverse biological activities.{27617,52199,52200} It inhibits aggregation of amyloid-β (1-42) (Aβ42; Item No. 20574) with an IC50 value of 3.54 μM and destabilizes preformed Aβ42 fibrils (EC50 = 5.12 μM).{27617} Procyanidin B3 (1 mM) reduces oxidation of linoleic acid and scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) free radicals in cell-free assays.{52199} It inhibits hydrogen peroxide-induced production of inducible nitric oxide synthase (iNOS) and apoptosis in primary murine chondrocytes.{52200} Procyanidin B3 (0.01 mg/kg) reduces chondrocyte apoptosis, pseudocapsule thickness, and the frequency of ectopic cartilage formation in a mouse model of surgically induced osteoarthritis.
Brand:CaymanSKU:29065 - 5 mgAvailable on backorder
Procyanidin C1 is a polyphenol flavonoid trimer of (–)-epicatechin (Item No. 11807) that has HIV-related and antioxidant activities.{41938,41939} It activates latent HIV-1 provirus in JLR2 cells when used at concentrations ranging from 12.5 to 50 µM and increases NF-κB-dependent transcriptional activity in Jurkat T cells.{41938} Procyanidin C1 also scavenges 2,2’-diphenyl-1-picrylhydrazyl (DPPH) radicals (IC50 = 3.2 µg/ml) and inhibits the activity of α-glucosidase (IC50 = 3.8 µg/ml) and 15-lipoxygenase (15-LO; IC50 = 57.6 µg/ml).{41939} Procyanidin C1 (10 µg/ml) prevents phosphorylation of ERK1/2 and the production of reactive oxygen species (ROS) in THP-1 cells.{34660}
Brand:CaymanSKU:25201 - 1 mgAvailable on backorder
Procyanidin C1 is a polyphenol flavonoid trimer of (–)-epicatechin (Item No. 11807) that has HIV-related and antioxidant activities.{41938,41939} It activates latent HIV-1 provirus in JLR2 cells when used at concentrations ranging from 12.5 to 50 µM and increases NF-κB-dependent transcriptional activity in Jurkat T cells.{41938} Procyanidin C1 also scavenges 2,2’-diphenyl-1-picrylhydrazyl (DPPH) radicals (IC50 = 3.2 µg/ml) and inhibits the activity of α-glucosidase (IC50 = 3.8 µg/ml) and 15-lipoxygenase (15-LO; IC50 = 57.6 µg/ml).{41939} Procyanidin C1 (10 µg/ml) prevents phosphorylation of ERK1/2 and the production of reactive oxygen species (ROS) in THP-1 cells.{34660}
Brand:CaymanSKU:25201 - 10 mgAvailable on backorder
Procyanidin C1 is a polyphenol flavonoid trimer of (–)-epicatechin (Item No. 11807) that has HIV-related and antioxidant activities.{41938,41939} It activates latent HIV-1 provirus in JLR2 cells when used at concentrations ranging from 12.5 to 50 µM and increases NF-κB-dependent transcriptional activity in Jurkat T cells.{41938} Procyanidin C1 also scavenges 2,2’-diphenyl-1-picrylhydrazyl (DPPH) radicals (IC50 = 3.2 µg/ml) and inhibits the activity of α-glucosidase (IC50 = 3.8 µg/ml) and 15-lipoxygenase (15-LO; IC50 = 57.6 µg/ml).{41939} Procyanidin C1 (10 µg/ml) prevents phosphorylation of ERK1/2 and the production of reactive oxygen species (ROS) in THP-1 cells.{34660}
Brand:CaymanSKU:25201 - 5 mgAvailable on backorder
Procysteine is a prodrug form of cysteine that is metabolized to cysteine intracellularly and has antioxidant activity.{58119,58120} It reduces TNF-α-induced increases in the expression of IL-6 and chemokine (C-C motif) ligand 2 (CCL2) in ARPE-19 human retinal pigment epithelial cells when used at a concentration of 0.5 mM.{58121} Procysteine (6.5 mmol/kg) also increases liver glutathione (GSH) levels in fasted, but not fed, mice.{58119} It reduces the production of reactive oxygen species (ROS) in bronchoalveolar lavage fluid (BALF) and decreases plasma extravasation in the lungs, as well as reverses decreases in the levels of hypoxia-inducible factor (HIF-1α) in a mouse model of allergic asthma when administered at doses of 80 and 160 mg/kg.{58120}
Brand:CaymanSKU:10006326 - 1 gAvailable on backorder
Procysteine is a prodrug form of cysteine that is metabolized to cysteine intracellularly and has antioxidant activity.{58119,58120} It reduces TNF-α-induced increases in the expression of IL-6 and chemokine (C-C motif) ligand 2 (CCL2) in ARPE-19 human retinal pigment epithelial cells when used at a concentration of 0.5 mM.{58121} Procysteine (6.5 mmol/kg) also increases liver glutathione (GSH) levels in fasted, but not fed, mice.{58119} It reduces the production of reactive oxygen species (ROS) in bronchoalveolar lavage fluid (BALF) and decreases plasma extravasation in the lungs, as well as reverses decreases in the levels of hypoxia-inducible factor (HIF-1α) in a mouse model of allergic asthma when administered at doses of 80 and 160 mg/kg.{58120}
Brand:CaymanSKU:10006326 - 10 gAvailable on backorder
Procysteine is a prodrug form of cysteine that is metabolized to cysteine intracellularly and has antioxidant activity.{58119,58120} It reduces TNF-α-induced increases in the expression of IL-6 and chemokine (C-C motif) ligand 2 (CCL2) in ARPE-19 human retinal pigment epithelial cells when used at a concentration of 0.5 mM.{58121} Procysteine (6.5 mmol/kg) also increases liver glutathione (GSH) levels in fasted, but not fed, mice.{58119} It reduces the production of reactive oxygen species (ROS) in bronchoalveolar lavage fluid (BALF) and decreases plasma extravasation in the lungs, as well as reverses decreases in the levels of hypoxia-inducible factor (HIF-1α) in a mouse model of allergic asthma when administered at doses of 80 and 160 mg/kg.{58120}
Brand:CaymanSKU:10006326 - 25 gAvailable on backorder
Procysteine is a prodrug form of cysteine that is metabolized to cysteine intracellularly and has antioxidant activity.{58119,58120} It reduces TNF-α-induced increases in the expression of IL-6 and chemokine (C-C motif) ligand 2 (CCL2) in ARPE-19 human retinal pigment epithelial cells when used at a concentration of 0.5 mM.{58121} Procysteine (6.5 mmol/kg) also increases liver glutathione (GSH) levels in fasted, but not fed, mice.{58119} It reduces the production of reactive oxygen species (ROS) in bronchoalveolar lavage fluid (BALF) and decreases plasma extravasation in the lungs, as well as reverses decreases in the levels of hypoxia-inducible factor (HIF-1α) in a mouse model of allergic asthma when administered at doses of 80 and 160 mg/kg.{58120}
Brand:CaymanSKU:10006326 - 5 gAvailable on backorder
Prodan is a solvatochromic fluorescent probe.{48680} It exhibits absorbance/emission maxima of 347/416 nm, respectively, in toluene, with both parameters increasing as solvent polarity increases. The emission maximum is also influenced by the phase state of membranes, such as in multilamellar vesicles containing 1,2-dipalmitoyl-sn-glycero-3-PC (DPPC; Item No. 10009473) wherein the emission maximum of prodan shifts from approximately 440 nm in the gel phase to approximately 490 nm in the liquid crystalline phase.{48681} Prodan has been used to probe the microenvironmental conditions of biological and synthetic membranes.{48681,48682}
Brand:CaymanSKU:27663 - 1 gAvailable on backorder
Prodan is a solvatochromic fluorescent probe.{48680} It exhibits absorbance/emission maxima of 347/416 nm, respectively, in toluene, with both parameters increasing as solvent polarity increases. The emission maximum is also influenced by the phase state of membranes, such as in multilamellar vesicles containing 1,2-dipalmitoyl-sn-glycero-3-PC (DPPC; Item No. 10009473) wherein the emission maximum of prodan shifts from approximately 440 nm in the gel phase to approximately 490 nm in the liquid crystalline phase.{48681} Prodan has been used to probe the microenvironmental conditions of biological and synthetic membranes.{48681,48682}
Brand:CaymanSKU:27663 - 100 mgAvailable on backorder
Prodan is a solvatochromic fluorescent probe.{48680} It exhibits absorbance/emission maxima of 347/416 nm, respectively, in toluene, with both parameters increasing as solvent polarity increases. The emission maximum is also influenced by the phase state of membranes, such as in multilamellar vesicles containing 1,2-dipalmitoyl-sn-glycero-3-PC (DPPC; Item No. 10009473) wherein the emission maximum of prodan shifts from approximately 440 nm in the gel phase to approximately 490 nm in the liquid crystalline phase.{48681} Prodan has been used to probe the microenvironmental conditions of biological and synthetic membranes.{48681,48682}
Brand:CaymanSKU:27663 - 250 mgAvailable on backorder
Prodan is a solvatochromic fluorescent probe.{48680} It exhibits absorbance/emission maxima of 347/416 nm, respectively, in toluene, with both parameters increasing as solvent polarity increases. The emission maximum is also influenced by the phase state of membranes, such as in multilamellar vesicles containing 1,2-dipalmitoyl-sn-glycero-3-PC (DPPC; Item No. 10009473) wherein the emission maximum of prodan shifts from approximately 440 nm in the gel phase to approximately 490 nm in the liquid crystalline phase.{48681} Prodan has been used to probe the microenvironmental conditions of biological and synthetic membranes.{48681,48682}
Brand:CaymanSKU:27663 - 500 mgAvailable on backorder
Prodigiosin is a natural red bacterial pigment that has antibiotic, antitumor, and immunosuppressant properties.{31059} It blocks T cell proliferation at a concentration of 30 ng/ml, by interfering with IL-2 receptor expression.{31056} Prodigiosin induces apoptosis in cancer cells by diverse mechanisms and rescues deficient p53 signaling.{31060,31057,31058} Prodigiosin derivatives can uncouple vacuolar H+-ATPase and inhibit osteoclast function.{31061} Prodigiosin is cytolytic against the red tide dinoflagellate Cochlodinium at very low concentrations (1 ppb), suggesting an application in controlling algal blooms.{31059}
Brand:CaymanSKU:-Available on backorder
Prodigiosin is a natural red bacterial pigment that has antibiotic, antitumor, and immunosuppressant properties.{31059} It blocks T cell proliferation at a concentration of 30 ng/ml, by interfering with IL-2 receptor expression.{31056} Prodigiosin induces apoptosis in cancer cells by diverse mechanisms and rescues deficient p53 signaling.{31060,31057,31058} Prodigiosin derivatives can uncouple vacuolar H+-ATPase and inhibit osteoclast function.{31061} Prodigiosin is cytolytic against the red tide dinoflagellate Cochlodinium at very low concentrations (1 ppb), suggesting an application in controlling algal blooms.{31059}
Brand:CaymanSKU:-Available on backorder
Prodigiosin is a natural red bacterial pigment that has antibiotic, antitumor, and immunosuppressant properties.{31059} It blocks T cell proliferation at a concentration of 30 ng/ml, by interfering with IL-2 receptor expression.{31056} Prodigiosin induces apoptosis in cancer cells by diverse mechanisms and rescues deficient p53 signaling.{31060,31057,31058} Prodigiosin derivatives can uncouple vacuolar H+-ATPase and inhibit osteoclast function.{31061} Prodigiosin is cytolytic against the red tide dinoflagellate Cochlodinium at very low concentrations (1 ppb), suggesting an application in controlling algal blooms.{31059}
Brand:CaymanSKU:-Available on backorder
Progesterone, along with pregnenolone, is the biosynthetic precursor of all other steroid hormones. Progesterone is synthesized from cholesterol by the sequential action of desmolase in the mitochondria, which produces pregnenolone, followed by Δ4,5-isomerase in the outer mitochondrial membrane and smooth endoplasmic reticulum of steroid-secreting cells.{8458} Progesterone activates the human progesterone receptor with an EC50 value of 0.5 nM.{25839}
Brand:CaymanSKU:- Progesterone, along with pregnenolone, is the biosynthetic precursor of all other steroid hormones. Progesterone is synthesized from cholesterol by the sequential action of desmolase in the mitochondria, which produces pregnenolone, followed by Δ4,5-isomerase in the outer mitochondrial membrane and smooth endoplasmic reticulum of steroid-secreting cells.{8458} Progesterone activates the human progesterone receptor with an EC50 value of 0.5 nM.{25839}
Brand:CaymanSKU:-
Brand:CaymanSKU:482602 - 100 dtnAvailable on backorder
Brand:CaymanSKU:482602 - 500 dtnAvailable on backorder
Progesterone, along with pregnenolone, is the biosynthetic precursor of all other steroid hormones. Progesterone is synthesized from cholesterol by the sequential action of desmolase in the mitochondria, which produces pregnenolone, followed by Δ4,5-isomerase in the outer mitochondrial membrane and smooth endoplasmic reticulum of steroid-secreting cells.{8458} The main function of progesterone is to prepare the uterine lining for implantation of a fertilized ovum and to maintain pregnancy. Measurement of serum or plasma progesterone levels are used as an index to monitor ovulation and investigate luteal function. Plasma concentrations of progesterone are approximately 0.2-0.8 ng/ml and 4-20 ng/ml during the follicular phase and luteal phase of the menstrual cycle, respectively.{8458} Salivary concentrations of progesterone are approximately 100-fold lower than those found in plasma.{1639}
Brand:CaymanSKU:582601 - 480 solid wellsAvailable on backorder
Progesterone, along with pregnenolone, is the biosynthetic precursor of all other steroid hormones. Progesterone is synthesized from cholesterol by the sequential action of desmolase in the mitochondria, which produces pregnenolone, followed by Δ4,5-isomerase in the outer mitochondrial membrane and smooth endoplasmic reticulum of steroid-secreting cells.{8458} The main function of progesterone is to prepare the uterine lining for implantation of a fertilized ovum and to maintain pregnancy. Measurement of serum or plasma progesterone levels are used as an index to monitor ovulation and investigate luteal function. Plasma concentrations of progesterone are approximately 0.2-0.8 ng/ml and 4-20 ng/ml during the follicular phase and luteal phase of the menstrual cycle, respectively.{8458} Salivary concentrations of progesterone are approximately 100-fold lower than those found in plasma.{1639}
Brand:CaymanSKU:582601 - 480 strip wellsAvailable on backorder
Progesterone, along with pregnenolone, is the biosynthetic precursor of all other steroid hormones. Progesterone is synthesized from cholesterol by the sequential action of desmolase in the mitochondria, which produces pregnenolone, followed by Δ4,5-isomerase in the outer mitochondrial membrane and smooth endoplasmic reticulum of steroid-secreting cells.{8458} The main function of progesterone is to prepare the uterine lining for implantation of a fertilized ovum and to maintain pregnancy. Measurement of serum or plasma progesterone levels are used as an index to monitor ovulation and investigate luteal function. Plasma concentrations of progesterone are approximately 0.2-0.8 ng/ml and 4-20 ng/ml during the follicular phase and luteal phase of the menstrual cycle, respectively.{8458} Salivary concentrations of progesterone are approximately 100-fold lower than those found in plasma.{1639}
Brand:CaymanSKU:582601 - 96 solid wellsAvailable on backorder
Progesterone, along with pregnenolone, is the biosynthetic precursor of all other steroid hormones. Progesterone is synthesized from cholesterol by the sequential action of desmolase in the mitochondria, which produces pregnenolone, followed by Δ4,5-isomerase in the outer mitochondrial membrane and smooth endoplasmic reticulum of steroid-secreting cells.{8458} The main function of progesterone is to prepare the uterine lining for implantation of a fertilized ovum and to maintain pregnancy. Measurement of serum or plasma progesterone levels are used as an index to monitor ovulation and investigate luteal function. Plasma concentrations of progesterone are approximately 0.2-0.8 ng/ml and 4-20 ng/ml during the follicular phase and luteal phase of the menstrual cycle, respectively.{8458} Salivary concentrations of progesterone are approximately 100-fold lower than those found in plasma.{1639}
Brand:CaymanSKU:582601 - 96 strip wellsAvailable on backorder
Brand:CaymanSKU:482604 - 1 eaAvailable on backorder
There is accumulating evidence to suggest that progesterone plays an essential role in the regulation of growth and differentiation of mammary glands and thus may play a key role in breast cancer.{14655} The biological response to progesterone is mediated by two distinct forms of the human progesterone receptor (PR-A and PR-B forms). In most cell contexts, the B form functions as a transcriptional activator, whereas the A form functions as a transcriptional inhibitor of steroid hormones.{14653,14656} Recently it has been demonstrated that there is differential hormone dependent regulation of the phosphorylation of the A and B forms of the receptor.{14654} Treatment of T47D breast cancer cells with progestin agonist increases the phosphorylation of Ser190 and Ser294 with different kinetics. These phosphorylation events may differentially affect the transcriptional activity of the receptor.
Brand:CaymanSKU:10009762 - 1 eaAvailable on backorder
Antigen: phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser294 of human progesterone receptor · Host: mouse · Cross-reactivity: (+) human Phospho-Ser294 progesterone receptor · Applications: WB and IHC (frozen sections)
Brand:CaymanSKU:10009762- 1 eaAvailable on backorder
Antigen: phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser294 of human progesterone receptor · Host: mouse · Cross-reactivity: (+) human Phospho-Ser294 progesterone receptor · Applications: WB and IHC (frozen sections)
Brand:CaymanSKU:10009762- 1 ea There is accumulating evidence to suggest that progesterone plays an essential role in the regulation of growth and differentiation of mammary glands and thus may play a key role in breast cancer.{14655} The biological response to progesterone is mediated by two distinct forms of the human progesterone receptor (PR-A and PR-B forms). In most cell contexts, the B form functions as a transcriptional activator, whereas the A form functions as a transcriptional inhibitor of steroid hormones.{14653,14656} Recently it has been demonstrated that there is differential hormone dependent regulation of the phosphorylation of the A and B forms of the receptor.{14654} Treatment of T47D breast cancer cells with progestin agonist increases the phosphorylation of Ser190 and Ser294 with different kinetics. These phosphorylation events may differentially affect the transcriptional activity of the receptor.
Brand:CaymanSKU:10009763 - 1 eaAvailable on backorder
Antigen: phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser294 of human progesterone receptor · Host: mouse · Cross-reactivity: (+) human progesterone receptor; expected to react with mouse, rat, non-human primates progesterone receptor based on 100% homology with the amino acid sequence used as the antigen · Application: WB and IHC (frozen sections)
Brand:CaymanSKU:10009763- 1 eaAvailable on backorder
Antigen: phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser294 of human progesterone receptor · Host: mouse · Cross-reactivity: (+) human progesterone receptor; expected to react with mouse, rat, non-human primates progesterone receptor based on 100% homology with the amino acid sequence used as the antigen · Application: WB and IHC (frozen sections)
Brand:CaymanSKU:10009763- 1 ea
Brand:CaymanSKU:32807 - 100 µlAvailable on backorder
Brand:CaymanSKU:32807- 100 µlAvailable on backorder
Brand:CaymanSKU:32807- 100 µl
Progesterone-d9 is intended for use as an internal standard for the quantification of progesterone (Item No. 15876) by GC- or LC-MS. Progesterone is the biosynthetic precursor of all other steroid hormones.{8458} Progesterone is synthesized from cholesterol by the sequential action of desmolase in the mitochondria, which produces pregnenolone, followed by Δ4,5-isomerase in the outer mitochondrial membrane and smooth endoplasmic reticulum of steroid-secreting cells. Progesterone activates the human progesterone receptor with an EC50 value of 0.5 nM.{25839}
Brand:CaymanSKU:25047 - 1 mgAvailable on backorder
Antigen: human PDCD4 C-terminal amino acids 458-468 • Host: rabbit • Cross Reactivity: (+) human, mouse, and rat PDCD4 • Application(s): WB • PDCD4 levels are elevated during apoptosis and absent in many cancer samples. Loss of PDCD4 expression is an important event in cancer cell progression whereas the restoration of PDCD4 protein can lower metalloproteinase activity and possible metastasis.
Brand:CaymanSKU:10250- 500 µl Programmed cell death protein 4 (PDCD4) levels are elevated during apoptosis and absent in many cancer samples.{16340,16167} Loss of PDCD4 expression is an important event in cancer cell progression whereas the restoration of PDCD4 protein can lower metalloproteinase activity and possible metastasis.{16167,16166} The known isoforms of PDCD4 differ only at the N-terminial with isoform 1 comprised of 468 amino acids and isoform 2 comprised of 458 amino acids. Each isoform contains two MA-3 domains essential for binding of PDCD4 binding to eIF4A, thereby suppressing cell cycle regulation and growth factor production.{16167,16166,16345} This antibody is capable of detecting both PDCD4 isoforms. Additional protein modifications are possible and can explain the range of masses detected by immunoblotting (52-64 kDa).{16340} The molecular mechanisms of PDCD4 influence on tumor suppression are becoming known but warrant further research.{16167,16166,16168}
Brand:CaymanSKU:10250 - 500 µlAvailable on backorder
Antigen: human PDCD4 C-terminal amino acids 458-468 • Host: rabbit • Cross Reactivity: (+) human, mouse, and rat PDCD4 • Application(s): WB • PDCD4 levels are elevated during apoptosis and absent in many cancer samples. Loss of PDCD4 expression is an important event in cancer cell progression whereas the restoration of PDCD4 protein can lower metalloproteinase activity and possible metastasis.
Brand:CaymanSKU:10250- 500 µlAvailable on backorder
Proguanil is a prodrug form of the antimalarial agent cycloguanil (Item No. 16861).{54317} Proguanil is metabolized by the cytochrome P450 (CYP) isoforms CYP2C19 and CYP3A to form cycloguanil in human liver microsomes. It is active against chloroquine- and quinine-resistant strains of P. falciparum alone or in combination with atovaquone (Item No. 23802) with EC50 values ranging from 0.22 to 2.67 and 0.37 to 1.6 µM, respectively.{52699} It reduces parasitemia in a mouse model of P. berghei infection with a minimum effective dose (MED) of 32 mg/kg.{52700} Formulations containing proguanil have been used in combination with atovaquone for the prevention and treatment of malaria.
Brand:CaymanSKU:30675 - 10 mgAvailable on backorder
Proguanil is a prodrug form of the antimalarial agent cycloguanil (Item No. 16861).{54317} Proguanil is metabolized by the cytochrome P450 (CYP) isoforms CYP2C19 and CYP3A to form cycloguanil in human liver microsomes. It is active against chloroquine- and quinine-resistant strains of P. falciparum alone or in combination with atovaquone (Item No. 23802) with EC50 values ranging from 0.22 to 2.67 and 0.37 to 1.6 µM, respectively.{52699} It reduces parasitemia in a mouse model of P. berghei infection with a minimum effective dose (MED) of 32 mg/kg.{52700} Formulations containing proguanil have been used in combination with atovaquone for the prevention and treatment of malaria.
Brand:CaymanSKU:30675 - 25 mgAvailable on backorder
Proguanil is a prodrug form of the antimalarial agent cycloguanil (Item No. 16861).{54317} Proguanil is metabolized by the cytochrome P450 (CYP) isoforms CYP2C19 and CYP3A to form cycloguanil in human liver microsomes. It is active against chloroquine- and quinine-resistant strains of P. falciparum alone or in combination with atovaquone (Item No. 23802) with EC50 values ranging from 0.22 to 2.67 and 0.37 to 1.6 µM, respectively.{52699} It reduces parasitemia in a mouse model of P. berghei infection with a minimum effective dose (MED) of 32 mg/kg.{52700} Formulations containing proguanil have been used in combination with atovaquone for the prevention and treatment of malaria.
Brand:CaymanSKU:30675 - 5 mgAvailable on backorder
Prolactin is a polypeptide hormone synthesized and secreted by the anterior pituitary gland, placenta, decidua, and by various immune system cells, such as T cells, B cells, and NK cells. It has many functions, including stimulating mammary glands to produce milk (lactation), stimulating surfactant in the fetal lungs at the end of pregnancy, inducing immune tolerance of the fetus during pregnancy, as well as other immuno-regulatory and reproductive functions, and may also have a role in breast cancer development. Cayman’s human Prolactin ELISA Kit is an immunometric (i.e., sandwich) ELISA that can be used to measure prolactin within the range of 0.12-100 ng/ml. This assay offers specific and sensitive analysis of prolactin in human serum and plasma, and has not been validated for other types of samples.
Brand:CaymanSKU:500730 - 1 eaAvailable on backorder
Prolactin (PRL) is a pituitary hormone whose molecular weight is approximately 23000 Daltons. It is a single polypeptide chain composed of about 200 amino acid residues with three disulphide bonds. In mammals prolactin has been claimed to exert a wide range of different physiological effects. These include stimulation of mammary gland development and lactation, hair maturation, synergism with androgen in male sex accessory growth and maintenance and secretion of corpus luteum. PRL is predominantly under inhibitory control by the hypothalamus. Stimulation of prolactin release can be mediated by dopamine and thyrotrophin-releasing hormone(TRH). [Bertin Catalog No. A05101]
Brand:CaymanSKU:589701 - 96 wellsAvailable on backorder
Prolactin releasing peptide (PrRP) is a 31-amino acid neuropeptide involved in regulating food intake.{43061} It is found in the hypothalamus, medulla, and pituitary in rats.{43062} PrRP is an agonist of the G-protein coupled receptors GPR10/hGR3 and neuropeptide FF receptor (hNPFF2; Kis = 1 and 19 nM, respectively).{43062,43063} It stimulates calcium mobilization in HEK293 cells expressing GPR10 (EC50 = 1.5 nM) and radiolabeled GTPγS binding to membrane homogenates from CHO cells transfected with hNPFF2 (EC50 = 240 nM).{43062,43063} PrRP (100 nM) increases the release of gonadotropin-releasing hormone (GnRH; Item No. 24762), vasoactive intestinal peptide (VIP; Item No. 24996), and galanin (Item No. 24456) from rat medial basal hypothalamic explants.{43064} It increases plasma levels of luteinizing hormone, follicle stimulating hormone, and testosterone in male rats when administered at an intracerebroventricular dose of 5 nmol.{43064} PrRP reduces food intake in fasted rats to 58.4, 53.4, and 55.4% of control levels when administered at doses of 1, 5, and 10 nmol, respectively.{43061}
Brand:CaymanSKU:24986 - 500 µgAvailable on backorder