Cayman

Showing 3451–3600 of 45550 results

  • 13(S)-HODE cholesteryl ester was originally extracted from atherosclerotic lesions.{2227} It remains uncertain whether the oxidized fatty acid portion of the molecule results from enzymatic lipoxygenation or from random lipid peroxidation.{1126} 13(S)-HODE cholesteryl ester can be used as a standard for analysis of chiral HODE cholesteryl esters.  

     

    Brand:
    Cayman
    SKU:38611 - 25 µg

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  • 13(S)-HODE cholesteryl ester was originally extracted from atherosclerotic lesions.{2227} It remains uncertain whether the oxidized fatty acid portion of the molecule results from enzymatic lipoxygenation or from random lipid peroxidation.{1126} 13(S)-HODE cholesteryl ester can be used as a standard for analysis of chiral HODE cholesteryl esters.  

     

    Brand:
    Cayman
    SKU:38611 - 50 µg

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  • 13(S)-hydroxyoctadecadienoic acid (13(S)-HODE) is a 15-lipoxygenase metabolite of linoleic acid produced in endothelial cells, leukocytes, and tumor cells. The biological effects of 13(S)-HODE include inhibition of tumor cell adhesion to the endothelium at concentrations around 1 µM,{592,880} and down regulation of IRGpIIb/IIIa receptor expression.{591} 13(S)-HODE methyl ester is a neutral, more lipophilic form of the free acid that can been used as an analytical standard for 13(S)-HODE.  

     

    Brand:
    Cayman
    SKU:10008875 - 1 mg

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  • 13(S)-hydroxyoctadecadienoic acid (13(S)-HODE) is a 15-lipoxygenase metabolite of linoleic acid produced in endothelial cells, leukocytes, and tumor cells. The biological effects of 13(S)-HODE include inhibition of tumor cell adhesion to the endothelium at concentrations around 1 µM,{592,880} and down regulation of IRGpIIb/IIIa receptor expression.{591} 13(S)-HODE methyl ester is a neutral, more lipophilic form of the free acid that can been used as an analytical standard for 13(S)-HODE.  

     

    Brand:
    Cayman
    SKU:10008875 - 100 µg

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  • 13(S)-hydroxyoctadecadienoic acid (13(S)-HODE) is a 15-lipoxygenase metabolite of linoleic acid produced in endothelial cells, leukocytes, and tumor cells. The biological effects of 13(S)-HODE include inhibition of tumor cell adhesion to the endothelium at concentrations around 1 µM,{592,880} and down regulation of IRGpIIb/IIIa receptor expression.{591} 13(S)-HODE methyl ester is a neutral, more lipophilic form of the free acid that can been used as an analytical standard for 13(S)-HODE.  

     

    Brand:
    Cayman
    SKU:10008875 - 500 µg

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  • 13(S)-HODE is the lipoxygenase metabolite of linoleic acid. 13(S)-HODE modulates the platelet-activating factor, leukotriene B4, and formyl-Met-Leu-Phe-induced calcium influx in human polymorphonuclear leukocytes.{7566} The mechanism by which 13(S)-HODE elicits its inhibitory effect is still unclear. The use of biotinylated 15(S)-HETE as a probe for detecting binding proteins and/or receptors that specifically bind 15(S)-HETE provides a basis for similar use of 13(S)-HODE-biotin.{6482}  

     

    Brand:
    Cayman
    SKU:38612 - 1 mg

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  • 13(S)-HODE is the lipoxygenase metabolite of linoleic acid. 13(S)-HODE modulates the platelet-activating factor, leukotriene B4, and formyl-Met-Leu-Phe-induced calcium influx in human polymorphonuclear leukocytes.{7566} The mechanism by which 13(S)-HODE elicits its inhibitory effect is still unclear. The use of biotinylated 15(S)-HETE as a probe for detecting binding proteins and/or receptors that specifically bind 15(S)-HETE provides a basis for similar use of 13(S)-HODE-biotin.{6482}  

     

    Brand:
    Cayman
    SKU:38612 - 100 µg

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  • 13(S)-HODE is the lipoxygenase metabolite of linoleic acid. 13(S)-HODE modulates the platelet-activating factor, leukotriene B4, and formyl-Met-Leu-Phe-induced calcium influx in human polymorphonuclear leukocytes.{7566} The mechanism by which 13(S)-HODE elicits its inhibitory effect is still unclear. The use of biotinylated 15(S)-HETE as a probe for detecting binding proteins and/or receptors that specifically bind 15(S)-HETE provides a basis for similar use of 13(S)-HODE-biotin.{6482}  

     

    Brand:
    Cayman
    SKU:38612 - 500 µg

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  • 13(S)-HODE-d4 contains four deuterium atoms at the 9, 10, 12, and 13 positions. It is intended for use as an internal standard for the quantification of 13(S)-HODE by GC- or LC-mass spectrometry. 13(S)-HODE is produced by incubation of linoleic acid with plant and mammalian lipoxygenases. It has been shown to inhibit the adhesion of tumor cells to the endothelium at concentrations around 1 µM,{592,880} and down regulates the expression of the IRGpIIb/IIIa receptor.{591}  

     

    Brand:
    Cayman
    SKU:338610 - 100 µg

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  • 13(S)-HODE-d4 contains four deuterium atoms at the 9, 10, 12, and 13 positions. It is intended for use as an internal standard for the quantification of 13(S)-HODE by GC- or LC-mass spectrometry. 13(S)-HODE is produced by incubation of linoleic acid with plant and mammalian lipoxygenases. It has been shown to inhibit the adhesion of tumor cells to the endothelium at concentrations around 1 µM,{592,880} and down regulates the expression of the IRGpIIb/IIIa receptor.{591}  

     

    Brand:
    Cayman
    SKU:338610 - 25 µg

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  • 13(S)-HODE-d4 contains four deuterium atoms at the 9, 10, 12, and 13 positions. It is intended for use as an internal standard for the quantification of 13(S)-HODE by GC- or LC-mass spectrometry. 13(S)-HODE is produced by incubation of linoleic acid with plant and mammalian lipoxygenases. It has been shown to inhibit the adhesion of tumor cells to the endothelium at concentrations around 1 µM,{592,880} and down regulates the expression of the IRGpIIb/IIIa receptor.{591}  

     

    Brand:
    Cayman
    SKU:338610 - 50 µg

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  • 13(S)-HOTrE is the 15-lipoxygenase (15-LO) product of linolenic acid. It has been detected in cell membranes and as the cholesteryl ester associated with the lesions of atherosclerosis, and in the biomembranes of soybeans exposed to 15-LO.{1126,1525}  

     

    Brand:
    Cayman
    SKU:39620 - 1 mg

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  • 13(S)-HOTrE is the 15-lipoxygenase (15-LO) product of linolenic acid. It has been detected in cell membranes and as the cholesteryl ester associated with the lesions of atherosclerosis, and in the biomembranes of soybeans exposed to 15-LO.{1126,1525}  

     

    Brand:
    Cayman
    SKU:39620 - 100 µg

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  • 13(S)-HOTrE is the 15-lipoxygenase (15-LO) product of linolenic acid. It has been detected in cell membranes and as the cholesteryl ester associated with the lesions of atherosclerosis, and in the biomembranes of soybeans exposed to 15-LO.{1126,1525}  

     

    Brand:
    Cayman
    SKU:39620 - 500 µg

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  • 13(S)-HOTrE(γ) is the 15-LO product of γ-linolenic acid. It is synthesized in human platelets, but its specific function is not known.{2517}  

     

    Brand:
    Cayman
    SKU:39610 - 1 mg

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  • 13(S)-HOTrE(γ) is the 15-LO product of γ-linolenic acid. It is synthesized in human platelets, but its specific function is not known.{2517}  

     

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    Cayman
    SKU:39610 - 100 µg

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  • 13(S)-HOTrE(γ) is the 15-LO product of γ-linolenic acid. It is synthesized in human platelets, but its specific function is not known.{2517}  

     

    Brand:
    Cayman
    SKU:39610 - 25 µg

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  • 13(S)-HOTrE(γ) is the 15-LO product of γ-linolenic acid. It is synthesized in human platelets, but its specific function is not known.{2517}  

     

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    Cayman
    SKU:39610 - 500 µg

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  • 13(S)-HpODE is produced by the oxidation of linoleic acid by lipoxygenase-1 (LO-1) in many plants including soybean, flaxseed, apples, and tea leaves,{123,770} and by 15-LO in mammals.{4193} In plants, 13(S)-HpODE is the preferred substrate for the garlic bulb divinyl ether synthase.{3824} In mammalian tissues, 13(S)-HpODE is generally reduced to 13(S)-HODE (Catalog No. 38610), a compound which exhibits many biological activities.{4193} A direct action for 13(S)-HpODE has been demonstrated in Syrian hamster embryo cells where it stimulates EGF-dependent mitogenesis and up-regulation of EGF-dependent tyrosine phosphorylation.{4902} Membrane-esterified 13(S)-HpODE has been identified in human atherosclerotic plaques.{2406}  

     

    Brand:
    Cayman
    SKU:48610 - 1 mg

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  • 13(S)-HpODE is produced by the oxidation of linoleic acid by lipoxygenase-1 (LO-1) in many plants including soybean, flaxseed, apples, and tea leaves,{123,770} and by 15-LO in mammals.{4193} In plants, 13(S)-HpODE is the preferred substrate for the garlic bulb divinyl ether synthase.{3824} In mammalian tissues, 13(S)-HpODE is generally reduced to 13(S)-HODE (Catalog No. 38610), a compound which exhibits many biological activities.{4193} A direct action for 13(S)-HpODE has been demonstrated in Syrian hamster embryo cells where it stimulates EGF-dependent mitogenesis and up-regulation of EGF-dependent tyrosine phosphorylation.{4902} Membrane-esterified 13(S)-HpODE has been identified in human atherosclerotic plaques.{2406}  

     

    Brand:
    Cayman
    SKU:48610 - 100 µg

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  • 13(S)-HpODE is produced by the oxidation of linoleic acid by lipoxygenase-1 (LO-1) in many plants including soybean, flaxseed, apples, and tea leaves,{123,770} and by 15-LO in mammals.{4193} In plants, 13(S)-HpODE is the preferred substrate for the garlic bulb divinyl ether synthase.{3824} In mammalian tissues, 13(S)-HpODE is generally reduced to 13(S)-HODE (Catalog No. 38610), a compound which exhibits many biological activities.{4193} A direct action for 13(S)-HpODE has been demonstrated in Syrian hamster embryo cells where it stimulates EGF-dependent mitogenesis and up-regulation of EGF-dependent tyrosine phosphorylation.{4902} Membrane-esterified 13(S)-HpODE has been identified in human atherosclerotic plaques.{2406}  

     

    Brand:
    Cayman
    SKU:48610 - 50 µg

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  • 13(S)-HpODE is produced by the oxidation of linoleic acid by lipoxygenase-1 (LO-1) in many plants including soybean, flaxseed, apples, and tea leaves,{123,770} and by 15-LO in mammals.{4193} In plants, 13(S)-HpODE is the preferred substrate for the garlic bulb divinyl ether synthase.{3824} In mammalian tissues, 13(S)-HpODE is generally reduced to 13(S)-HODE (Catalog No. 38610), a compound which exhibits many biological activities.{4193} A direct action for 13(S)-HpODE has been demonstrated in Syrian hamster embryo cells where it stimulates EGF-dependent mitogenesis and up-regulation of EGF-dependent tyrosine phosphorylation.{4902} Membrane-esterified 13(S)-HpODE has been identified in human atherosclerotic plaques.{2406}  

     

    Brand:
    Cayman
    SKU:48610 - 500 µg

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  • 13(S)-HpOTrE is a monohydroperoxy polyunsaturated fatty acid produced in soybeans by the action of soybean LO-2 on esterified α-linolenic acid.{1525} Incubation of soybean seedling biomembranes with soybean LO-2 catalyzes the formation of both 9- and 13-HpOTrE in a molar ratio of 10:1.{1525} In plants, 13(S)-HpOTrE can be metabolized by the hydroperoxide lyase pathway producing aldehyde and oxoacid fragments, or by the hydroperoxide dehydratase pathway producing jasmonic acid.{770,2009,1829} Treatment of tomato leaves with 13-HpOTrE causes induction of proteinase inhibitors, simulating the normal response to wounding.{5107} This data suggests that in plants 13(S)-HpOTrE may participate in a lipid-based signalling system initiated by insect and pathogen attack.  

     

    Brand:
    Cayman
    SKU:45220 - 1 mg

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  • 13(S)-HpOTrE is a monohydroperoxy polyunsaturated fatty acid produced in soybeans by the action of soybean LO-2 on esterified α-linolenic acid.{1525} Incubation of soybean seedling biomembranes with soybean LO-2 catalyzes the formation of both 9- and 13-HpOTrE in a molar ratio of 10:1.{1525} In plants, 13(S)-HpOTrE can be metabolized by the hydroperoxide lyase pathway producing aldehyde and oxoacid fragments, or by the hydroperoxide dehydratase pathway producing jasmonic acid.{770,2009,1829} Treatment of tomato leaves with 13-HpOTrE causes induction of proteinase inhibitors, simulating the normal response to wounding.{5107} This data suggests that in plants 13(S)-HpOTrE may participate in a lipid-based signalling system initiated by insect and pathogen attack.  

     

    Brand:
    Cayman
    SKU:45220 - 100 µg

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  • 13(S)-HpOTrE is a monohydroperoxy polyunsaturated fatty acid produced in soybeans by the action of soybean LO-2 on esterified α-linolenic acid.{1525} Incubation of soybean seedling biomembranes with soybean LO-2 catalyzes the formation of both 9- and 13-HpOTrE in a molar ratio of 10:1.{1525} In plants, 13(S)-HpOTrE can be metabolized by the hydroperoxide lyase pathway producing aldehyde and oxoacid fragments, or by the hydroperoxide dehydratase pathway producing jasmonic acid.{770,2009,1829} Treatment of tomato leaves with 13-HpOTrE causes induction of proteinase inhibitors, simulating the normal response to wounding.{5107} This data suggests that in plants 13(S)-HpOTrE may participate in a lipid-based signalling system initiated by insect and pathogen attack.  

     

    Brand:
    Cayman
    SKU:45220 - 500 µg

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  • 13(S)-HpOTrE(γ) is a monohydroxy PUFA produced by the action of soybean lipoxygenase-1 (LO-1) on γ-linolenic acid.{455} Further action of soybean LO-1 converts 13(S)-HpOTrE(γ) to all four isomers of 6,13-DiHOTrE.{6680} At concentrations greater than 100 µM, 13(S)-HpOTrE(γ) inhibits the activity of soybean LO-1.{119}  

     

    Brand:
    Cayman
    SKU:45210 - 1 mg

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  • 13(S)-HpOTrE(γ) is a monohydroxy PUFA produced by the action of soybean lipoxygenase-1 (LO-1) on γ-linolenic acid.{455} Further action of soybean LO-1 converts 13(S)-HpOTrE(γ) to all four isomers of 6,13-DiHOTrE.{6680} At concentrations greater than 100 µM, 13(S)-HpOTrE(γ) inhibits the activity of soybean LO-1.{119}  

     

    Brand:
    Cayman
    SKU:45210 - 100 µg

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  • 13(S)-HpOTrE(γ) is a monohydroxy PUFA produced by the action of soybean lipoxygenase-1 (LO-1) on γ-linolenic acid.{455} Further action of soybean LO-1 converts 13(S)-HpOTrE(γ) to all four isomers of 6,13-DiHOTrE.{6680} At concentrations greater than 100 µM, 13(S)-HpOTrE(γ) inhibits the activity of soybean LO-1.{119}  

     

    Brand:
    Cayman
    SKU:45210 - 5 mg

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  • 13(S)-HpOTrE(γ) is a monohydroxy PUFA produced by the action of soybean lipoxygenase-1 (LO-1) on γ-linolenic acid.{455} Further action of soybean LO-1 converts 13(S)-HpOTrE(γ) to all four isomers of 6,13-DiHOTrE.{6680} At concentrations greater than 100 µM, 13(S)-HpOTrE(γ) inhibits the activity of soybean LO-1.{119}  

     

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    Cayman
    SKU:45210 - 500 µg

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  • 13(Z)-Docosenoic acid is a 22-carbon monounsaturated fatty acid. It is found predominantly in canola oil.{8144} 13(Z)-Docosenoic acid is metabolized to oleic acid in vivo. Diets rich in 13(Z)-docosenoic acid were shown to cause heart lipidosis in experimental animals.{7786,8145} The C-1 amide of docosenoic acid has been identified as one of the anandamide-related neurotransmitters associated with sleep.{1317}  

     

    Brand:
    Cayman
    SKU:90175 - 100 mg

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  • 13(Z)-Docosenoic acid is a 22-carbon monounsaturated fatty acid. It is found predominantly in canola oil.{8144} 13(Z)-Docosenoic acid is metabolized to oleic acid in vivo. Diets rich in 13(Z)-docosenoic acid were shown to cause heart lipidosis in experimental animals.{7786,8145} The C-1 amide of docosenoic acid has been identified as one of the anandamide-related neurotransmitters associated with sleep.{1317}  

     

    Brand:
    Cayman
    SKU:90175 - 250 mg

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  • 13(Z)-Docosenoic acid is a 22-carbon monounsaturated fatty acid. It is found predominantly in canola oil.{8144} 13(Z)-Docosenoic acid is metabolized to oleic acid in vivo. Diets rich in 13(Z)-docosenoic acid were shown to cause heart lipidosis in experimental animals.{7786,8145} The C-1 amide of docosenoic acid has been identified as one of the anandamide-related neurotransmitters associated with sleep.{1317}  

     

    Brand:
    Cayman
    SKU:90175 - 50 mg

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  • 13(Z)-Docosenoic acid is a 22-carbon monounsaturated fatty acid. It is found predominantly in canola oil.{8144} 13(Z)-Docosenoic acid is metabolized to oleic acid in vivo. Diets rich in 13(Z)-docosenoic acid were shown to cause heart lipidosis in experimental animals.{7786,8145} The C-1 amide of docosenoic acid has been identified as one of the anandamide-related neurotransmitters associated with sleep.{1317}  

     

    Brand:
    Cayman
    SKU:90175 - 500 mg

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  • 13(Z)-Docosenoic acid methyl ester is a fatty acid methyl ester that is a flavor-active, volatile, and aromatic compound found in cooked commercial shrimp waste.{38924} It is a component of biodiesel formed from C. megalocarpus and C. pentandra oils that contain trierucin.{38925} 13(Z)-Docosenoic acid methyl ester has also been used as a standard for the quantification of 13(Z)-docosenoic acid (Item No. 90175) by GC-MS.{38926}  

     

    Brand:
    Cayman
    SKU:20568 -

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  • 13(Z)-Docosenoic acid methyl ester is a fatty acid methyl ester that is a flavor-active, volatile, and aromatic compound found in cooked commercial shrimp waste.{38924} It is a component of biodiesel formed from C. megalocarpus and C. pentandra oils that contain trierucin.{38925} 13(Z)-Docosenoic acid methyl ester has also been used as a standard for the quantification of 13(Z)-docosenoic acid (Item No. 90175) by GC-MS.{38926}  

     

    Brand:
    Cayman
    SKU:20568 -

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  • 13(Z)-Docosenoic acid methyl ester is a fatty acid methyl ester that is a flavor-active, volatile, and aromatic compound found in cooked commercial shrimp waste.{38924} It is a component of biodiesel formed from C. megalocarpus and C. pentandra oils that contain trierucin.{38925} 13(Z)-Docosenoic acid methyl ester has also been used as a standard for the quantification of 13(Z)-docosenoic acid (Item No. 90175) by GC-MS.{38926}  

     

    Brand:
    Cayman
    SKU:20568 -

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  • 13(Z)-Docosenoic acid methyl ester is a fatty acid methyl ester that is a flavor-active, volatile, and aromatic compound found in cooked commercial shrimp waste.{38924} It is a component of biodiesel formed from C. megalocarpus and C. pentandra oils that contain trierucin.{38925} 13(Z)-Docosenoic acid methyl ester has also been used as a standard for the quantification of 13(Z)-docosenoic acid (Item No. 90175) by GC-MS.{38926}  

     

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    Cayman
    SKU:20568 -

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  • 13(Z)-Eicosenoic acid is an ω-7 fatty acid found in a variety of fish from the Indian, Atlantic, and Pacific oceans.{49083} It increases triglyceride accumulation in 3T3-L1 cells when used at a concentration of 50 μM.{49084}  

     

    Brand:
    Cayman
    SKU:26169 - 10 mg

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  • 13(Z)-Eicosenoic acid is an ω-7 fatty acid found in a variety of fish from the Indian, Atlantic, and Pacific oceans.{49083} It increases triglyceride accumulation in 3T3-L1 cells when used at a concentration of 50 μM.{49084}  

     

    Brand:
    Cayman
    SKU:26169 - 25 mg

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  • 13(Z)-Eicosenoic acid is an ω-7 fatty acid found in a variety of fish from the Indian, Atlantic, and Pacific oceans.{49083} It increases triglyceride accumulation in 3T3-L1 cells when used at a concentration of 50 μM.{49084}  

     

    Brand:
    Cayman
    SKU:26169 - 5 mg

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  • 13C15-Nivalenol is intended for use as an internal standard for the quantification of nivalenol (Item No. 11438) by GC- or LC-MS. Nivalenol is a trichothecene mycotoxin that has been found in Fusarium.{32197} It is lethal to mice (LD50 = 6.9 mg/kg).{59482} Nivalenol (5, 10, and 15 mg/kg) also induces thymic, splenic, and Peyer’s patch cell apoptosis in mice.{59483}  

     

    Brand:
    Cayman
    SKU:31259 - 1.2 ml

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  • 13C6 Glucosylsphingosine (d18:1) is an isotopically enriched form of 1-β-D-glucosylsphingosine (d18:1) (Item No. 23211) that is intended for use as an internal standard for the quantification of 1-β-D-glucosylsphingosine by GC- or LC-MS. 1-β-D-Glucosylsphingosine is a lysolipid derivative of glucosylcerebroside that decreases activity of glucocerebrosidase in LA-N-2 cells in a dose-dependent manner.{41130,41131} [Matreya, LLC. Catalog No. 2209]  

     

    Brand:
    Cayman
    SKU:23212 - 1 mg

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  • 13C6-3-Nitrophenylhydrazine is a 13C-labeled derivatizing reagent for carboxylic acids.{32632} It is useful for LC-MS analysis of volatile acids such as short chain fatty acids.  

     

    Brand:
    Cayman
    SKU:20744 -

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  • 13C6-3-Nitrophenylhydrazine is a 13C-labeled derivatizing reagent for carboxylic acids.{32632} It is useful for LC-MS analysis of volatile acids such as short chain fatty acids.  

     

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    Cayman
    SKU:20744 -

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  • 13C6-3-Nitrophenylhydrazine is a 13C-labeled derivatizing reagent for carboxylic acids.{32632} It is useful for LC-MS analysis of volatile acids such as short chain fatty acids.  

     

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    Cayman
    SKU:20744 -

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  • 13Z,16Z-Docosadienoic acid is a natural ω-6 polyunsaturated fatty acid (PUFA). It is an agonist of free fatty acid receptor 4 (FFAR4, also known as GPR120) and strongly inhibits the secretion of ghrelin by isolated mouse gastric cells.{32737} This 20:2 PUFA has been identified in mammals, fish, plants, and anaerobic fungi.{32733,32734,32735,32736,32738}  

     

    Brand:
    Cayman
    SKU:20749 -

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  • 13Z,16Z-Docosadienoic acid is a natural ω-6 polyunsaturated fatty acid (PUFA). It is an agonist of free fatty acid receptor 4 (FFAR4, also known as GPR120) and strongly inhibits the secretion of ghrelin by isolated mouse gastric cells.{32737} This 20:2 PUFA has been identified in mammals, fish, plants, and anaerobic fungi.{32733,32734,32735,32736,32738}  

     

    Brand:
    Cayman
    SKU:20749 -

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  • 13Z,16Z-Docosadienoic acid is a natural ω-6 polyunsaturated fatty acid (PUFA). It is an agonist of free fatty acid receptor 4 (FFAR4, also known as GPR120) and strongly inhibits the secretion of ghrelin by isolated mouse gastric cells.{32737} This 20:2 PUFA has been identified in mammals, fish, plants, and anaerobic fungi.{32733,32734,32735,32736,32738}  

     

    Brand:
    Cayman
    SKU:20749 -

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  • 14-Anhydrodigitoxigenin is a cardenolide and a derivative of digitoxin.{48892} It reduces the activity of guinea pig heart Na+/K+-ATPase by 15% when used at a concentration of 10 µM.{48893}  

     

    Brand:
    Cayman
    SKU:30439 - 10 mg

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  • 14-Anhydrodigitoxigenin is a cardenolide and a derivative of digitoxin.{48892} It reduces the activity of guinea pig heart Na+/K+-ATPase by 15% when used at a concentration of 10 µM.{48893}  

     

    Brand:
    Cayman
    SKU:30439 - 25 mg

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  • 14-Anhydrodigitoxigenin is a cardenolide and a derivative of digitoxin.{48892} It reduces the activity of guinea pig heart Na+/K+-ATPase by 15% when used at a concentration of 10 µM.{48893}  

     

    Brand:
    Cayman
    SKU:30439 - 5 mg

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  • 14-Anhydrodigitoxigenin is a cardenolide and a derivative of digitoxin.{48892} It reduces the activity of guinea pig heart Na+/K+-ATPase by 15% when used at a concentration of 10 µM.{48893}  

     

    Brand:
    Cayman
    SKU:30439 - 50 mg

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  • 14-dehydro Zymostenol is a precursor to cholesterol (Item No. 9003100).{52493} It increases the percentage of myelin basic protein-positive (MBP+) oligodendrocytes formed from oligodendrocyte precursor cells when used at concentrations of 5.8 and 17 µM.{48202}  

     

    Brand:
    Cayman
    SKU:29534 - 1 mg

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  • 14-dehydro Zymostenol is a precursor to cholesterol (Item No. 9003100).{52493} It increases the percentage of myelin basic protein-positive (MBP+) oligodendrocytes formed from oligodendrocyte precursor cells when used at concentrations of 5.8 and 17 µM.{48202}  

     

    Brand:
    Cayman
    SKU:29534 - 5 mg

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  • 14-dehydro Zymostenol is a precursor to cholesterol (Item No. 9003100).{52493} It increases the percentage of myelin basic protein-positive (MBP+) oligodendrocytes formed from oligodendrocyte precursor cells when used at concentrations of 5.8 and 17 µM.{48202}  

     

    Brand:
    Cayman
    SKU:29534 - 500 µg

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  • 14-deoxy-11,12-didehydro Andrographolide is an analog of the natural diterpenoid andrographolide (Item No. 11679) that can be isolated from A. paniculata.{28452} It retains the anti-inflammatory, antiallergenic, immuno-stimulatory, antiviral, antioxidant, hepatoprotective, and cardiovascular activities of andrographolide without producing cytotoxicity in KB cells (ED50 >20 µg/ml) that can occur with andrographolide 6.5 µg/ml.{28452,21112}  

     

    Brand:
    Cayman
    SKU:11670 - 1 mg

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  • 14-deoxy-11,12-didehydro Andrographolide is an analog of the natural diterpenoid andrographolide (Item No. 11679) that can be isolated from A. paniculata.{28452} It retains the anti-inflammatory, antiallergenic, immuno-stimulatory, antiviral, antioxidant, hepatoprotective, and cardiovascular activities of andrographolide without producing cytotoxicity in KB cells (ED50 >20 µg/ml) that can occur with andrographolide 6.5 µg/ml.{28452,21112}  

     

    Brand:
    Cayman
    SKU:11670 - 10 mg

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  • 14-deoxy-11,12-didehydro Andrographolide is an analog of the natural diterpenoid andrographolide (Item No. 11679) that can be isolated from A. paniculata.{28452} It retains the anti-inflammatory, antiallergenic, immuno-stimulatory, antiviral, antioxidant, hepatoprotective, and cardiovascular activities of andrographolide without producing cytotoxicity in KB cells (ED50 >20 µg/ml) that can occur with andrographolide 6.5 µg/ml.{28452,21112}  

     

    Brand:
    Cayman
    SKU:11670 - 5 mg

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  • 14-deoxy-11,12-didehydro Andrographolide is an analog of the natural diterpenoid andrographolide (Item No. 11679) that can be isolated from A. paniculata.{28452} It retains the anti-inflammatory, antiallergenic, immuno-stimulatory, antiviral, antioxidant, hepatoprotective, and cardiovascular activities of andrographolide without producing cytotoxicity in KB cells (ED50 >20 µg/ml) that can occur with andrographolide 6.5 µg/ml.{28452,21112}  

     

    Brand:
    Cayman
    SKU:11670 - 500 µg

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  • 14-Deoxyandrographolide is a diterpene lactone that has been found in A. paniculata and has diverse biological activities, including anticancer, hepatoprotective, antioxidative, and antidiabetic properties.{58034},{58035},{58036},{58037} It inhibits the growth of HL-60 cells with a GI50 value of 25.46 µM and is cytotoxic to T47D cells (EC50 = 2.8 µg/ml) but not HepG2 or NCI H23 cells (EC50s = 28.3 and 26.4 µg/ml, respectively).{58034},{58035} 14-Deoxyandrographolide (10 and 25 µM) increases AMPK phosphorylation and glucose uptake in L6 myotubes and potentiates the effect of insulin to increase cell surface levels of GLUT4 in L6-GLUT4myc cells.{58037} It reduces blood glucose levels in rats in a model of streptozotocin-induced diabetes and in db/db diabetic mice when administered at a dose of 100 mg/kg. 14-Deoxyandrographolide reduces ethanol-induced hepatotoxicity in rats when administered at a dose of 15 mg/kg per day for the last four weeks of an eight-week ethanol exposure period.{58036} It also reduces protein carbonyl and thiobarbituric acid reactive substances (TBARS) levels and increases total glutathione (GSH) levels in isolated rat hepatocytes in the same model.  

     

    Brand:
    Cayman
    SKU:31140 - 1 mg

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  • 14-Deoxyandrographolide is a diterpene lactone that has been found in A. paniculata and has diverse biological activities, including anticancer, hepatoprotective, antioxidative, and antidiabetic properties.{58034},{58035},{58036},{58037} It inhibits the growth of HL-60 cells with a GI50 value of 25.46 µM and is cytotoxic to T47D cells (EC50 = 2.8 µg/ml) but not HepG2 or NCI H23 cells (EC50s = 28.3 and 26.4 µg/ml, respectively).{58034},{58035} 14-Deoxyandrographolide (10 and 25 µM) increases AMPK phosphorylation and glucose uptake in L6 myotubes and potentiates the effect of insulin to increase cell surface levels of GLUT4 in L6-GLUT4myc cells.{58037} It reduces blood glucose levels in rats in a model of streptozotocin-induced diabetes and in db/db diabetic mice when administered at a dose of 100 mg/kg. 14-Deoxyandrographolide reduces ethanol-induced hepatotoxicity in rats when administered at a dose of 15 mg/kg per day for the last four weeks of an eight-week ethanol exposure period.{58036} It also reduces protein carbonyl and thiobarbituric acid reactive substances (TBARS) levels and increases total glutathione (GSH) levels in isolated rat hepatocytes in the same model.  

     

    Brand:
    Cayman
    SKU:31140 - 10 mg

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  • 14-Deoxyandrographolide is a diterpene lactone that has been found in A. paniculata and has diverse biological activities, including anticancer, hepatoprotective, antioxidative, and antidiabetic properties.{58034},{58035},{58036},{58037} It inhibits the growth of HL-60 cells with a GI50 value of 25.46 µM and is cytotoxic to T47D cells (EC50 = 2.8 µg/ml) but not HepG2 or NCI H23 cells (EC50s = 28.3 and 26.4 µg/ml, respectively).{58034},{58035} 14-Deoxyandrographolide (10 and 25 µM) increases AMPK phosphorylation and glucose uptake in L6 myotubes and potentiates the effect of insulin to increase cell surface levels of GLUT4 in L6-GLUT4myc cells.{58037} It reduces blood glucose levels in rats in a model of streptozotocin-induced diabetes and in db/db diabetic mice when administered at a dose of 100 mg/kg. 14-Deoxyandrographolide reduces ethanol-induced hepatotoxicity in rats when administered at a dose of 15 mg/kg per day for the last four weeks of an eight-week ethanol exposure period.{58036} It also reduces protein carbonyl and thiobarbituric acid reactive substances (TBARS) levels and increases total glutathione (GSH) levels in isolated rat hepatocytes in the same model.  

     

    Brand:
    Cayman
    SKU:31140 - 5 mg

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  • 14-Deoxyandrographolide is a diterpene lactone that has been found in A. paniculata and has diverse biological activities, including anticancer, hepatoprotective, antioxidative, and antidiabetic properties.{58034},{58035},{58036},{58037} It inhibits the growth of HL-60 cells with a GI50 value of 25.46 µM and is cytotoxic to T47D cells (EC50 = 2.8 µg/ml) but not HepG2 or NCI H23 cells (EC50s = 28.3 and 26.4 µg/ml, respectively).{58034},{58035} 14-Deoxyandrographolide (10 and 25 µM) increases AMPK phosphorylation and glucose uptake in L6 myotubes and potentiates the effect of insulin to increase cell surface levels of GLUT4 in L6-GLUT4myc cells.{58037} It reduces blood glucose levels in rats in a model of streptozotocin-induced diabetes and in db/db diabetic mice when administered at a dose of 100 mg/kg. 14-Deoxyandrographolide reduces ethanol-induced hepatotoxicity in rats when administered at a dose of 15 mg/kg per day for the last four weeks of an eight-week ethanol exposure period.{58036} It also reduces protein carbonyl and thiobarbituric acid reactive substances (TBARS) levels and increases total glutathione (GSH) levels in isolated rat hepatocytes in the same model.  

     

    Brand:
    Cayman
    SKU:31140 - 500 µg

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  • 14-methyl Palmitic acid is a methylated fatty acid that has been found in bacteria, bovine milk fat, Aegean jellyfish (A. aurita), and one-humped camel (C. dromedarius) meat and fat.{40922,40923,38743,40924} It is also found in human breast milk and levels are decreased in mature breast milk compared to colostrum.{40925} 14-methyl Palmitic acid is produced in Florida manatee (T. manatus latirostris) liver in response to brevetoxin exposure.{40926} [Matreya, LLC. Catalog No. 1616]  

     

    Brand:
    Cayman
    SKU:24820 - 1 mg

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  • 14-methyl Palmitic acid is a methylated fatty acid that has been found in bacteria, bovine milk fat, Aegean jellyfish (A. aurita), and one-humped camel (C. dromedarius) meat and fat.{40922,40923,38743,40924} It is also found in human breast milk and levels are decreased in mature breast milk compared to colostrum.{40925} 14-methyl Palmitic acid is produced in Florida manatee (T. manatus latirostris) liver in response to brevetoxin exposure.{40926} [Matreya, LLC. Catalog No. 1616]  

     

    Brand:
    Cayman
    SKU:24820 - 5 mg

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  • 14-methyl Palmitic acid methyl ester is a methylated fatty acid methyl ester that has been found in A. indica leaf extract, S. alboflavus TD-1, and as a minor component in biodiesel produced from C. sorokiniana microalgae.{40917,40921,40919} It is a volatile compound released by maize that reduces growth of F. verticillioides in a concentration-dependent manner.{40920} 14-methyl Palmitic acid methyl ester has been used as a standard for the quantification of 14-methyl palmitic acid (Item No. 24820) in various foods by GC-MS.{40918} [Matreya, LLC. Catalog No. 1614]  

     

    Brand:
    Cayman
    SKU:24821 - 1 mg

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  • 14-methyl Palmitic acid methyl ester is a methylated fatty acid methyl ester that has been found in A. indica leaf extract, S. alboflavus TD-1, and as a minor component in biodiesel produced from C. sorokiniana microalgae.{40917,40921,40919} It is a volatile compound released by maize that reduces growth of F. verticillioides in a concentration-dependent manner.{40920} 14-methyl Palmitic acid methyl ester has been used as a standard for the quantification of 14-methyl palmitic acid (Item No. 24820) in various foods by GC-MS.{40918} [Matreya, LLC. Catalog No. 1614]  

     

    Brand:
    Cayman
    SKU:24821 - 10 mg

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  • 14-methyl Palmitic acid methyl ester is a methylated fatty acid methyl ester that has been found in A. indica leaf extract, S. alboflavus TD-1, and as a minor component in biodiesel produced from C. sorokiniana microalgae.{40917,40921,40919} It is a volatile compound released by maize that reduces growth of F. verticillioides in a concentration-dependent manner.{40920} 14-methyl Palmitic acid methyl ester has been used as a standard for the quantification of 14-methyl palmitic acid (Item No. 24820) in various foods by GC-MS.{40918} [Matreya, LLC. Catalog No. 1614]  

     

    Brand:
    Cayman
    SKU:24821 - 5 mg

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  • 14-methyl Pentadecanoic acid methyl ester is a methylated fatty acid methyl ester that has been found in S. zeai sea sponges as the fatty acyl component of zeamide, A. indica leaf extract, and C. vulgaris and H. pluvialis microalgae.{40928,40917,40927} It is a major component of the vancomycin-induced biofilm produced by vancomycin-resistant S. aureus (VRSA).{40929} 14-methyl Pentadecanoic acid methyl ester has been used as a standard for the quantification of 14-methyl pentadecanoic acid in various foods by GC-MS.{40918} [Matreya, LLC. Catalog No. 1601]  

     

    Brand:
    Cayman
    SKU:24813 - 1 mg

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  • 14-methyl Pentadecanoic acid methyl ester is a methylated fatty acid methyl ester that has been found in S. zeai sea sponges as the fatty acyl component of zeamide, A. indica leaf extract, and C. vulgaris and H. pluvialis microalgae.{40928,40917,40927} It is a major component of the vancomycin-induced biofilm produced by vancomycin-resistant S. aureus (VRSA).{40929} 14-methyl Pentadecanoic acid methyl ester has been used as a standard for the quantification of 14-methyl pentadecanoic acid in various foods by GC-MS.{40918} [Matreya, LLC. Catalog No. 1601]  

     

    Brand:
    Cayman
    SKU:24813 - 10 mg

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  • 14-methyl Pentadecanoic acid methyl ester is a methylated fatty acid methyl ester that has been found in S. zeai sea sponges as the fatty acyl component of zeamide, A. indica leaf extract, and C. vulgaris and H. pluvialis microalgae.{40928,40917,40927} It is a major component of the vancomycin-induced biofilm produced by vancomycin-resistant S. aureus (VRSA).{40929} 14-methyl Pentadecanoic acid methyl ester has been used as a standard for the quantification of 14-methyl pentadecanoic acid in various foods by GC-MS.{40918} [Matreya, LLC. Catalog No. 1601]  

     

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    Cayman
    SKU:24813 - 5 mg

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  • 14-Pentadecenoic acid is a 15-carbon, long-chain fatty acid that contains an alkene functional group on the terminal carbon of its aliphatic tail. The oxidation pattern of this fatty acid resulting from growth of M. cerificans at the expense of the parent alkene has been reported.{31487} 14-Pentadecenoic acid has been used in the fabrication of fibrous scaffold biomaterials for tissue engineering applications and for the construction of metallomesogenic side-chain polymers that coat capillary columns used in gas chromatography.{31485,31486}  

     

    Brand:
    Cayman
    SKU:19724 -

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  • 14-Pentadecenoic acid is a 15-carbon, long-chain fatty acid that contains an alkene functional group on the terminal carbon of its aliphatic tail. The oxidation pattern of this fatty acid resulting from growth of M. cerificans at the expense of the parent alkene has been reported.{31487} 14-Pentadecenoic acid has been used in the fabrication of fibrous scaffold biomaterials for tissue engineering applications and for the construction of metallomesogenic side-chain polymers that coat capillary columns used in gas chromatography.{31485,31486}  

     

    Brand:
    Cayman
    SKU:19724 -

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  • 14-Pentadecenoic acid is a 15-carbon, long-chain fatty acid that contains an alkene functional group on the terminal carbon of its aliphatic tail. The oxidation pattern of this fatty acid resulting from growth of M. cerificans at the expense of the parent alkene has been reported.{31487} 14-Pentadecenoic acid has been used in the fabrication of fibrous scaffold biomaterials for tissue engineering applications and for the construction of metallomesogenic side-chain polymers that coat capillary columns used in gas chromatography.{31485,31486}  

     

    Brand:
    Cayman
    SKU:19724 -

    Available on backorder

  • 14-Pentadecenoic acid is a 15-carbon, long-chain fatty acid that contains an alkene functional group on the terminal carbon of its aliphatic tail. The oxidation pattern of this fatty acid resulting from growth of M. cerificans at the expense of the parent alkene has been reported.{31487} 14-Pentadecenoic acid has been used in the fabrication of fibrous scaffold biomaterials for tissue engineering applications and for the construction of metallomesogenic side-chain polymers that coat capillary columns used in gas chromatography.{31485,31486}  

     

    Brand:
    Cayman
    SKU:19724 -

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  • Leukotriene B4 (LTB4) is a dihydroxy fatty acid derived from arachidonic acid through the 5-lipoxygenase pathway.{521,948} It promotes a number of leukocyte functions including aggregation, stimulation of ion fluxes, enhancement of lysosomal enzyme release, superoxide anion production, chemotaxis, and chemokinesis.{329,82} At least two LTB4 receptors, termed BLT1 and BLT2, have been identified. 14,15-dehydro LTB4 is a LTB4 receptor antagonist that has a higher binding affinity for BLT1, demonstrating a Ki value of 27 nM, compared to BLT2, which has a Ki value of 473 nM.{8743} 14,15-dehydro LTB4 inhibits LTB4-induced release of lysozymes from rat polymorphonuclear leukoctyes with an IC50 value of 1 µM.{384}  

     

    Brand:
    Cayman
    SKU:20150 -

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  • Leukotriene B4 (LTB4) is a dihydroxy fatty acid derived from arachidonic acid through the 5-lipoxygenase pathway.{521,948} It promotes a number of leukocyte functions including aggregation, stimulation of ion fluxes, enhancement of lysosomal enzyme release, superoxide anion production, chemotaxis, and chemokinesis.{329,82} At least two LTB4 receptors, termed BLT1 and BLT2, have been identified. 14,15-dehydro LTB4 is a LTB4 receptor antagonist that has a higher binding affinity for BLT1, demonstrating a Ki value of 27 nM, compared to BLT2, which has a Ki value of 473 nM.{8743} 14,15-dehydro LTB4 inhibits LTB4-induced release of lysozymes from rat polymorphonuclear leukoctyes with an IC50 value of 1 µM.{384}  

     

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    Cayman
    SKU:20150 -

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  • Leukotriene B4 (LTB4) is a dihydroxy fatty acid derived from arachidonic acid through the 5-lipoxygenase pathway.{521,948} It promotes a number of leukocyte functions including aggregation, stimulation of ion fluxes, enhancement of lysosomal enzyme release, superoxide anion production, chemotaxis, and chemokinesis.{329,82} At least two LTB4 receptors, termed BLT1 and BLT2, have been identified. 14,15-dehydro LTB4 is a LTB4 receptor antagonist that has a higher binding affinity for BLT1, demonstrating a Ki value of 27 nM, compared to BLT2, which has a Ki value of 473 nM.{8743} 14,15-dehydro LTB4 inhibits LTB4-induced release of lysozymes from rat polymorphonuclear leukoctyes with an IC50 value of 1 µM.{384}  

     

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    Cayman
    SKU:20150 -

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  • Epoxyeicosatrienoic acids (EETs), such as 11(12)-EET and 14(15)-EET, are cytochrome P450 metabolites of arachidonic acid that have been identified as endothelium-derived hyperpolarizing factors with vasodilator activity.{12391} 14,15-EE-5(Z)-E is a structural analog of 14,15-epoxyeicosatrienoic acids (14,15-EET) that antagonizes EET-induced relaxation of vascular smooth muscle.{14412} Relaxation of U46619-constricted bovine arteries by 14,15-EET could be inhibited approximately 80% by 14,15-EE-5(Z)-E at a concentration of 10 µM. 14,15-EE-5(Z)-E does not appear to antagonize nitric oxide- or iloprost-mediated vascular relaxation.  

     

    Brand:
    Cayman
    SKU:10004946 - 100 µg

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  • Epoxyeicosatrienoic acids (EETs), such as 11(12)-EET and 14(15)-EET, are cytochrome P450 metabolites of arachidonic acid that have been identified as endothelium-derived hyperpolarizing factors with vasodilator activity.{12391} 14,15-EE-5(Z)-E is a structural analog of 14,15-epoxyeicosatrienoic acids (14,15-EET) that antagonizes EET-induced relaxation of vascular smooth muscle.{14412} Relaxation of U46619-constricted bovine arteries by 14,15-EET could be inhibited approximately 80% by 14,15-EE-5(Z)-E at a concentration of 10 µM. 14,15-EE-5(Z)-E does not appear to antagonize nitric oxide- or iloprost-mediated vascular relaxation.  

     

    Brand:
    Cayman
    SKU:10004946 - 25 µg

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  • Epoxyeicosatrienoic acids (EETs), such as 11(12)-EET and 14(15)-EET, are cytochrome P450 metabolites of arachidonic acid that have been identified as endothelium-derived hyperpolarizing factors with vasodilator activity.{12391} 14,15-EE-5(Z)-E is a structural analog of 14,15-epoxyeicosatrienoic acids (14,15-EET) that antagonizes EET-induced relaxation of vascular smooth muscle.{14412} Relaxation of U46619-constricted bovine arteries by 14,15-EET could be inhibited approximately 80% by 14,15-EE-5(Z)-E at a concentration of 10 µM. 14,15-EE-5(Z)-E does not appear to antagonize nitric oxide- or iloprost-mediated vascular relaxation.  

     

    Brand:
    Cayman
    SKU:10004946 - 50 µg

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  • Epoxyeicosatrienoic acids (EETs), such as 11(12)-EET and 14(15)-EET, are cytochrome P450 metabolites of arachidonic acid that have been identified as endothelium-derived hyperpolarizing factors with vasodilator activity.{12391} 14,15-EE-5(Z)-E is a structural analog of 14,15-epoxyeicosatrienoic acids (14,15-EET) that antagonizes EET-induced relaxation of vascular smooth muscle.{14412} Relaxation of U46619-constricted bovine arteries by 14,15-EET could be inhibited approximately 80% by 14,15-EE-5(Z)-E at a concentration of 10 µM. 14,15-EE-5(Z)-E does not appear to antagonize nitric oxide- or iloprost-mediated vascular relaxation.  

     

    Brand:
    Cayman
    SKU:10004946 - 500 µg

    Available on backorder

  • Epoxyeicosatrienoic acids (EETs), such as 11(12)-EET and 14(15)-EET, are cytochrome P450 metabolites of arachidonic acid that have been identified as endothelium-derived hyperpolarizing factors with vasodilator activity.{15770} 14,15-EE-8(Z)-E is a structural analog of 14(15)-EET that demonstrates potent vasodilator agonist activity in bovine coronary arteries similar to that of 14(15)-EET.{14714,14413}  

     

    Brand:
    Cayman
    SKU:10010486 - 100 µg

    Available on backorder

  • Epoxyeicosatrienoic acids (EETs), such as 11(12)-EET and 14(15)-EET, are cytochrome P450 metabolites of arachidonic acid that have been identified as endothelium-derived hyperpolarizing factors with vasodilator activity.{15770} 14,15-EE-8(Z)-E is a structural analog of 14(15)-EET that demonstrates potent vasodilator agonist activity in bovine coronary arteries similar to that of 14(15)-EET.{14714,14413}  

     

    Brand:
    Cayman
    SKU:10010486 - 25 µg

    Available on backorder

  • Epoxyeicosatrienoic acids (EETs), such as 11(12)-EET and 14(15)-EET, are cytochrome P450 metabolites of arachidonic acid that have been identified as endothelium-derived hyperpolarizing factors with vasodilator activity.{15770} 14,15-EE-8(Z)-E is a structural analog of 14(15)-EET that demonstrates potent vasodilator agonist activity in bovine coronary arteries similar to that of 14(15)-EET.{14714,14413}  

     

    Brand:
    Cayman
    SKU:10010486 - 50 µg

    Available on backorder

  • Epoxyeicosatrienoic acids (EETs), such as 11(12)-EET and 14(15)-EET, are cytochrome P450 metabolites of arachidonic acid that have been identified as endothelium-derived hyperpolarizing factors with vasodilator activity.{15770} 14,15-EE-8(Z)-E is a structural analog of 14(15)-EET that demonstrates potent vasodilator agonist activity in bovine coronary arteries similar to that of 14(15)-EET.{14714,14413}  

     

    Brand:
    Cayman
    SKU:10010486 - 500 µg

    Available on backorder

  • 14,15-Leukotriene A4 (14,15-LTA4) methyl ester is an esterified form of 14,15-LTA4, a leukotriene isomer formed from arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) by 15-lipoxygenase (15-LO) that inhibits LTA4 hydrolase.{391,45244}  

     

    Brand:
    Cayman
    SKU:10011359 - 100 µg

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  • 14,15-Leukotriene A4 (14,15-LTA4) methyl ester is an esterified form of 14,15-LTA4, a leukotriene isomer formed from arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) by 15-lipoxygenase (15-LO) that inhibits LTA4 hydrolase.{391,45244}  

     

    Brand:
    Cayman
    SKU:10011359 - 25 µg

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  • 14,15-Leukotriene A4 (14,15-LTA4) methyl ester is an esterified form of 14,15-LTA4, a leukotriene isomer formed from arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) by 15-lipoxygenase (15-LO) that inhibits LTA4 hydrolase.{391,45244}  

     

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    Cayman
    SKU:10011359 - 50 µg

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  • Leukotrienes (LTs) are a group of acute inflammatory mediators derived from arachidonic acid in leukocytes. The majority of these metabolites are formed through the 5-lipoxygenase (5-LO) pathway.{11267} 14,15-LTC4 is a member of an alternate class of LTs synthesized by a pathway involving the dual actions of 15- and 12-LOs on arachidonic acid via 15-HpETE and 14,15-LTA4 intermediates.{453,391,15256,11160} 14,15-LTC4 is classified as an eoxin, because it is formed mostly by eosinophils.{15256} However, mast cells and nasal polyps can synthesize 14,15-LTC4 as well. Little is known about the physiological actions of 14,15-LTC4. It has weak contractile activity on both guinea pig ileum and pulmonary parenchyma in contrast to the effects of 5-LO-derived LTs.{11158,11187} However, in an in vitro permeability assay, 14,15-LTC4 can increase vascular permeability of human endothelial cell monolayers, with similar potency to that of 5-LO-derived LTs resulting in plasma leakage – a hallmark of inflammation.{15256}  

     

    Brand:
    Cayman
    SKU:10011360 - 100 µg

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  • Leukotrienes (LTs) are a group of acute inflammatory mediators derived from arachidonic acid in leukocytes. The majority of these metabolites are formed through the 5-lipoxygenase (5-LO) pathway.{11267} 14,15-LTC4 is a member of an alternate class of LTs synthesized by a pathway involving the dual actions of 15- and 12-LOs on arachidonic acid via 15-HpETE and 14,15-LTA4 intermediates.{453,391,15256,11160} 14,15-LTC4 is classified as an eoxin, because it is formed mostly by eosinophils.{15256} However, mast cells and nasal polyps can synthesize 14,15-LTC4 as well. Little is known about the physiological actions of 14,15-LTC4. It has weak contractile activity on both guinea pig ileum and pulmonary parenchyma in contrast to the effects of 5-LO-derived LTs.{11158,11187} However, in an in vitro permeability assay, 14,15-LTC4 can increase vascular permeability of human endothelial cell monolayers, with similar potency to that of 5-LO-derived LTs resulting in plasma leakage – a hallmark of inflammation.{15256}  

     

    Brand:
    Cayman
    SKU:10011360 - 25 µg

    Available on backorder

  • Leukotrienes (LTs) are a group of acute inflammatory mediators derived from arachidonic acid in leukocytes. The majority of these metabolites are formed through the 5-lipoxygenase (5-LO) pathway.{11267} 14,15-LTC4 is a member of an alternate class of LTs synthesized by a pathway involving the dual actions of 15- and 12-LOs on arachidonic acid via 15-HpETE and 14,15-LTA4 intermediates.{453,391,15256,11160} 14,15-LTC4 is classified as an eoxin, because it is formed mostly by eosinophils.{15256} However, mast cells and nasal polyps can synthesize 14,15-LTC4 as well. Little is known about the physiological actions of 14,15-LTC4. It has weak contractile activity on both guinea pig ileum and pulmonary parenchyma in contrast to the effects of 5-LO-derived LTs.{11158,11187} However, in an in vitro permeability assay, 14,15-LTC4 can increase vascular permeability of human endothelial cell monolayers, with similar potency to that of 5-LO-derived LTs resulting in plasma leakage – a hallmark of inflammation.{15256}  

     

    Brand:
    Cayman
    SKU:10011360 - 50 µg

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  • 14,15-Leukotriene D4 (14,15-LTD4) is a member of an alternate class of LTs synthesized by a pathway involving the dual actions of 15- and 12-lipoxygenases (15- and 12-LOs) on arachidonic acid via 15-HpETE and 14,15-LTA4 intermediates.{453,391,15256,11160} 14,15-LTD4 is classified as an eoxin (EXD4), because it is formed mostly by eosinophils.{15256} However, mast cells and nasal polyps can synthesize 14,15-LTD4 as well. Little is known about the physiological actions of 14,15-LTD4. It has weak contractile activity on both guinea pig ileum and pulmonary parenchyma in contrast to the effects of 5-LO-derived LTs.{11158,11187} However, in an in vitro permeability assay, 14,15-LTD4 can increase vascular permeability of human endothelial cell monolayers, with similar potency to that of 5-LO-derived LTs, resulting in plasma leakage, a hallmark of inflammation.{15256}  

     

    Brand:
    Cayman
    SKU:10011361 - 100 µg

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  • 14,15-Leukotriene D4 (14,15-LTD4) is a member of an alternate class of LTs synthesized by a pathway involving the dual actions of 15- and 12-lipoxygenases (15- and 12-LOs) on arachidonic acid via 15-HpETE and 14,15-LTA4 intermediates.{453,391,15256,11160} 14,15-LTD4 is classified as an eoxin (EXD4), because it is formed mostly by eosinophils.{15256} However, mast cells and nasal polyps can synthesize 14,15-LTD4 as well. Little is known about the physiological actions of 14,15-LTD4. It has weak contractile activity on both guinea pig ileum and pulmonary parenchyma in contrast to the effects of 5-LO-derived LTs.{11158,11187} However, in an in vitro permeability assay, 14,15-LTD4 can increase vascular permeability of human endothelial cell monolayers, with similar potency to that of 5-LO-derived LTs, resulting in plasma leakage, a hallmark of inflammation.{15256}  

     

    Brand:
    Cayman
    SKU:10011361 - 25 µg

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  • 14,15-Leukotriene D4 (14,15-LTD4) is a member of an alternate class of LTs synthesized by a pathway involving the dual actions of 15- and 12-lipoxygenases (15- and 12-LOs) on arachidonic acid via 15-HpETE and 14,15-LTA4 intermediates.{453,391,15256,11160} 14,15-LTD4 is classified as an eoxin (EXD4), because it is formed mostly by eosinophils.{15256} However, mast cells and nasal polyps can synthesize 14,15-LTD4 as well. Little is known about the physiological actions of 14,15-LTD4. It has weak contractile activity on both guinea pig ileum and pulmonary parenchyma in contrast to the effects of 5-LO-derived LTs.{11158,11187} However, in an in vitro permeability assay, 14,15-LTD4 can increase vascular permeability of human endothelial cell monolayers, with similar potency to that of 5-LO-derived LTs, resulting in plasma leakage, a hallmark of inflammation.{15256}  

     

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    Cayman
    SKU:10011361 - 50 µg

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  • Leukotrienes (LTs) are a group of acute inflammatory mediators derived from arachidonic acid in leukocytes. The majority of these metabolites are formed through the 5-lipoxygenase (5-LO) pathway.{11267} 14,15-LTE4 is a metabolite of 14,15-LTC4 and 14,15-LTD4, an alternate class of LTs synthesized by a pathway involving the dual actions of 15- and 12-LOs on arachidonic acid via 15-HpETE and 14,15-LTA4 intermediates.{453,391,15256,11160} These metabolites are classified as eoxins because they are formed mostly by eosinophils.{15256} Mast cells and nasal polyps can synthesize 14,15-LTC4 as well, however metabolism to 14,15-LTE4 in these cells and tissue has not been documented. 14,15-LTE4 increases vascular permeability of human endothelial cell monolayers with about 10-fold less potency than LTC4, but approximately 100-fold greater potency than histamine.{15256}  

     

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    Cayman
    SKU:10011362 - 100 µg

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  • Leukotrienes (LTs) are a group of acute inflammatory mediators derived from arachidonic acid in leukocytes. The majority of these metabolites are formed through the 5-lipoxygenase (5-LO) pathway.{11267} 14,15-LTE4 is a metabolite of 14,15-LTC4 and 14,15-LTD4, an alternate class of LTs synthesized by a pathway involving the dual actions of 15- and 12-LOs on arachidonic acid via 15-HpETE and 14,15-LTA4 intermediates.{453,391,15256,11160} These metabolites are classified as eoxins because they are formed mostly by eosinophils.{15256} Mast cells and nasal polyps can synthesize 14,15-LTC4 as well, however metabolism to 14,15-LTE4 in these cells and tissue has not been documented. 14,15-LTE4 increases vascular permeability of human endothelial cell monolayers with about 10-fold less potency than LTC4, but approximately 100-fold greater potency than histamine.{15256}  

     

    Brand:
    Cayman
    SKU:10011362 - 25 µg

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  • Leukotrienes (LTs) are a group of acute inflammatory mediators derived from arachidonic acid in leukocytes. The majority of these metabolites are formed through the 5-lipoxygenase (5-LO) pathway.{11267} 14,15-LTE4 is a metabolite of 14,15-LTC4 and 14,15-LTD4, an alternate class of LTs synthesized by a pathway involving the dual actions of 15- and 12-LOs on arachidonic acid via 15-HpETE and 14,15-LTA4 intermediates.{453,391,15256,11160} These metabolites are classified as eoxins because they are formed mostly by eosinophils.{15256} Mast cells and nasal polyps can synthesize 14,15-LTC4 as well, however metabolism to 14,15-LTE4 in these cells and tissue has not been documented. 14,15-LTE4 increases vascular permeability of human endothelial cell monolayers with about 10-fold less potency than LTC4, but approximately 100-fold greater potency than histamine.{15256}  

     

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    Cayman
    SKU:10011362 - 50 µg

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  • 14(S)-HDHA is an oxygenation product formed by 12-lipoxygenase (12-LO) or 15-LO processing of docosahexaenoic acid (DHA; Item No. 90310).{16640} It is a precursor to the pro-resolving mediator maresin 1 (Item No. 10878) and has been found in peritoneal exudates isolated from a mouse model of zymosan-induced peritonitis.  

     

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    SKU:-
  • 14(S)-HDHA is an oxygenation product formed by 12-lipoxygenase (12-LO) or 15-LO processing of docosahexaenoic acid (DHA; Item No. 90310).{16640} It is a precursor to the pro-resolving mediator maresin 1 (Item No. 10878) and has been found in peritoneal exudates isolated from a mouse model of zymosan-induced peritonitis.  

     

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    Cayman
    SKU:-
  • 14(S)-HDHA is an oxygenation product formed by 12-lipoxygenase (12-LO) or 15-LO processing of docosahexaenoic acid (DHA; Item No. 90310).{16640} It is a precursor to the pro-resolving mediator maresin 1 (Item No. 10878) and has been found in peritoneal exudates isolated from a mouse model of zymosan-induced peritonitis.  

     

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    Cayman
    SKU:-
  • 14(S)-HDHA is an oxygenation product formed by 12-lipoxygenase (12-LO) or 15-LO processing of docosahexaenoic acid (DHA; Item No. 90310).{16640} It is a precursor to the pro-resolving mediator maresin 1 (Item No. 10878) and has been found in peritoneal exudates isolated from a mouse model of zymosan-induced peritonitis. 14(S)-HDHA MaxSpec® standard is a quantitative grade standard of 14(S)-HDHA (Item No. 15253) that has been prepared specifically for mass spectrometry and related applications where quantitative reproducibility is required. The solution has been prepared gravimetrically and is supplied in a deactivated glass ampule sealed under argon. The concentration was verified by comparison to an independently prepared calibration standard. This 14(S)-HDHA MaxSpec® standard is guaranteed to meet identity, purity, stability, and concentration specifications and is provided with a batch-specific certificate of analysis. Ongoing stability testing is performed to ensure the concentration remains accurate throughout the shelf life of the product. Note: The amount of solution added to the vial is in excess of the listed amount. Therefore, it is necessary to accurately measure volumes for preparation of calibration standards. Follow recommended storage and handling conditions to maintain product quality.  

     

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    Cayman
    SKU:29142 - 10 µg

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  • 14(Z)-Eicosenoic acid is a monounsaturated fatty acid. It is found in small quantities in marine life including the sponge (Tedania dirhaphis) and goldfish (Carassius auratus).{14592,14593} Potentially it could be the product of fatty acid chain elongation of 12(Z)-oleic acid.  

     

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    Cayman
    SKU:10009375 - 1 mg

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  • 14(Z)-Eicosenoic acid is a monounsaturated fatty acid. It is found in small quantities in marine life including the sponge (Tedania dirhaphis) and goldfish (Carassius auratus).{14592,14593} Potentially it could be the product of fatty acid chain elongation of 12(Z)-oleic acid.  

     

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    Cayman
    SKU:10009375 - 10 mg

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  • 14(Z)-Eicosenoic acid is a monounsaturated fatty acid. It is found in small quantities in marine life including the sponge (Tedania dirhaphis) and goldfish (Carassius auratus).{14592,14593} Potentially it could be the product of fatty acid chain elongation of 12(Z)-oleic acid.  

     

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    Cayman
    SKU:10009375 - 25 mg

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  • 14(Z)-Eicosenoic acid is a monounsaturated fatty acid. It is found in small quantities in marine life including the sponge (Tedania dirhaphis) and goldfish (Carassius auratus).{14592,14593} Potentially it could be the product of fatty acid chain elongation of 12(Z)-oleic acid.  

     

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    Cayman
    SKU:10009375 - 5 mg

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  • 1400W is a potent, selective inhibitor of iNOS.{4277} Using purified human iNOS, nNOS, and eNOS, 1400W exhibits Ki values of 7 nM, 2 µM, and 50 µM, respectively.{4277} In rat aortic rings it is at least 1,000-fold more potent against iNOS compared to eNOS.{4277} In mice bearing a murine mammary carcinoma, continuous infusion of 1400W at a rate of 10 mg/kg for 6 days decreased tumor weight approximately 50% compared to controls.{5066}  

     

    Brand:
    Cayman
    SKU:81520 - 10 mg

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  • 1400W is a potent, selective inhibitor of iNOS.{4277} Using purified human iNOS, nNOS, and eNOS, 1400W exhibits Ki values of 7 nM, 2 µM, and 50 µM, respectively.{4277} In rat aortic rings it is at least 1,000-fold more potent against iNOS compared to eNOS.{4277} In mice bearing a murine mammary carcinoma, continuous infusion of 1400W at a rate of 10 mg/kg for 6 days decreased tumor weight approximately 50% compared to controls.{5066}  

     

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    Cayman
    SKU:81520 - 100 mg

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  • 1400W is a potent, selective inhibitor of iNOS.{4277} Using purified human iNOS, nNOS, and eNOS, 1400W exhibits Ki values of 7 nM, 2 µM, and 50 µM, respectively.{4277} In rat aortic rings it is at least 1,000-fold more potent against iNOS compared to eNOS.{4277} In mice bearing a murine mammary carcinoma, continuous infusion of 1400W at a rate of 10 mg/kg for 6 days decreased tumor weight approximately 50% compared to controls.{5066}  

     

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    Cayman
    SKU:81520 - 5 mg

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  • 1400W is a potent, selective inhibitor of iNOS.{4277} Using purified human iNOS, nNOS, and eNOS, 1400W exhibits Ki values of 7 nM, 2 µM, and 50 µM, respectively.{4277} In rat aortic rings it is at least 1,000-fold more potent against iNOS compared to eNOS.{4277} In mice bearing a murine mammary carcinoma, continuous infusion of 1400W at a rate of 10 mg/kg for 6 days decreased tumor weight approximately 50% compared to controls.{5066}  

     

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    Cayman
    SKU:81520 - 50 mg

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  • 14S(15R)-EET is an oxylipin and a cytochrome P450 metabolite of arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607).{52397} 14S(15R)-EET binds to isolated guinea pig monocytes with a Ki value of 612.5 nM in a competitive binding assay using [3H]14(15)-EET.{52398} It induces dilation of precontracted isolated canine epicardial arterioles (EC50 = 4 pM) and denuded porcine subepicardial arterioles (EC50 = 3 pM).{52399} Unlike 14R(15S)-EET, 14S(15R)-EET does not inhibit COX in enzyme assays or isolated platelets.{642}  

     

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    Cayman
    SKU:28631 - 10 µg

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  • 14S(15R)-EET is an oxylipin and a cytochrome P450 metabolite of arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607).{52397} 14S(15R)-EET binds to isolated guinea pig monocytes with a Ki value of 612.5 nM in a competitive binding assay using [3H]14(15)-EET.{52398} It induces dilation of precontracted isolated canine epicardial arterioles (EC50 = 4 pM) and denuded porcine subepicardial arterioles (EC50 = 3 pM).{52399} Unlike 14R(15S)-EET, 14S(15R)-EET does not inhibit COX in enzyme assays or isolated platelets.{642}  

     

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    Cayman
    SKU:28631 - 100 µg

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  • 14S(15R)-EET is an oxylipin and a cytochrome P450 metabolite of arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607).{52397} 14S(15R)-EET binds to isolated guinea pig monocytes with a Ki value of 612.5 nM in a competitive binding assay using [3H]14(15)-EET.{52398} It induces dilation of precontracted isolated canine epicardial arterioles (EC50 = 4 pM) and denuded porcine subepicardial arterioles (EC50 = 3 pM).{52399} Unlike 14R(15S)-EET, 14S(15R)-EET does not inhibit COX in enzyme assays or isolated platelets.{642}  

     

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    Cayman
    SKU:28631 - 25 µg

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  • 14S(15R)-EET is an oxylipin and a cytochrome P450 metabolite of arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607).{52397} 14S(15R)-EET binds to isolated guinea pig monocytes with a Ki value of 612.5 nM in a competitive binding assay using [3H]14(15)-EET.{52398} It induces dilation of precontracted isolated canine epicardial arterioles (EC50 = 4 pM) and denuded porcine subepicardial arterioles (EC50 = 3 pM).{52399} Unlike 14R(15S)-EET, 14S(15R)-EET does not inhibit COX in enzyme assays or isolated platelets.{642}  

     

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    Cayman
    SKU:28631 - 50 µg

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  • 14α-hydroxy Paspalinine is an indole diterpene fungal metabolite originally isolated from A. nomius.{43042} Dietary administration of 14α-hydroxy paspalinine (100 ppm) reduces weight gain of H. zea first instar larvae by 91%.  

     

    Brand:
    Cayman
    SKU:25081 - 1 mg

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  • 14α-hydroxy Paspalinine is an indole diterpene fungal metabolite originally isolated from A. nomius.{43042} Dietary administration of 14α-hydroxy paspalinine (100 ppm) reduces weight gain of H. zea first instar larvae by 91%.  

     

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    Cayman
    SKU:25081 - 5 mg

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  • 15-acetoxy Scirpenol is a trichothecene mycotoxin that is produced predominantly by members of the Fusarium genus.{31918} It can induce apoptotic cell death in human Jurkat T cells.{31922}  

     

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    Cayman
    SKU:11431 - 1 mg

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  • 15-acetoxy Scirpenol is a trichothecene mycotoxin that is produced predominantly by members of the Fusarium genus.{31918} It can induce apoptotic cell death in human Jurkat T cells.{31922}  

     

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    Cayman
    SKU:11431 - 5 mg

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  • 15-Acetyldeoxy nivalenol is a trichothecene mycotoxin produced by certain species of the fungus Fusarium, particularly those found on cereal crops.{31919} It is an acetylated derivative of 4-deoxy nivalenol (DON; Item No. 11428) that can be converted to DON in the body. 15-Acetyldeoxy nivalenol induces vomiting and anorexia in livestock and experimental animals and its toxicity compared with DON is dependent upon the route of administration.{41122,41121} It also changes brain bioamine neurotransmitter levels in pigs and chickens.{24415}  

     

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    Cayman
    SKU:11430 - 1 mg

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  • 15-deoxy-Δ12,14-Prostaglandin A1 (15-deoxy-Δ12,14-PGA1) is a synthetic PGA1 analog. It shares common structural features with 15-deoxy-Δ12,14-PGJ2, which is a ligand for PPARγ.{1428} Antimitotic and antitumor activity have been reported for a similar analog, but there are no published reports on the biological activity of 15-deoxy-Δ12,14-PGA1 at this time.{334}  

     

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    Cayman
    SKU:10065 - 1 mg

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  • 15-deoxy-Δ12,14-Prostaglandin A1 (15-deoxy-Δ12,14-PGA1) is a synthetic PGA1 analog. It shares common structural features with 15-deoxy-Δ12,14-PGJ2, which is a ligand for PPARγ.{1428} Antimitotic and antitumor activity have been reported for a similar analog, but there are no published reports on the biological activity of 15-deoxy-Δ12,14-PGA1 at this time.{334}  

     

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    Cayman
    SKU:10065 - 5 mg

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  • 15-deoxy-Δ12,14-Prostaglandin A1 (15-deoxy-Δ12,14-PGA1) is a synthetic PGA1 analog. It shares common structural features with 15-deoxy-Δ12,14-PGJ2, which is a ligand for PPARγ.{1428} Antimitotic and antitumor activity have been reported for a similar analog, but there are no published reports on the biological activity of 15-deoxy-Δ12,14-PGA1 at this time.{334}  

     

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    Cayman
    SKU:10065 - 500 µg

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  • 15-deoxy-Δ12,14-PGA2 is a synthetic analog of PGA2. It shares common structural features with 15-deoxy-Δ12,14-PGJ2, which is a ligand for PPARγ.{1428,1424} Antimitotic and antitumor activity have been reported for a similar analog,{334} but there are no published reports on the biological activity of 15-deoxy-Δ12,14-PGA2 at this time.  

     

    Brand:
    Cayman
    SKU:10265 - 1 mg

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  • 15-deoxy-Δ12,14-PGA2 is a synthetic analog of PGA2. It shares common structural features with 15-deoxy-Δ12,14-PGJ2, which is a ligand for PPARγ.{1428,1424} Antimitotic and antitumor activity have been reported for a similar analog,{334} but there are no published reports on the biological activity of 15-deoxy-Δ12,14-PGA2 at this time.  

     

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    Cayman
    SKU:10265 - 5 mg

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  • 15-deoxy-Δ12,14-PGA2 is a synthetic analog of PGA2. It shares common structural features with 15-deoxy-Δ12,14-PGJ2, which is a ligand for PPARγ.{1428,1424} Antimitotic and antitumor activity have been reported for a similar analog,{334} but there are no published reports on the biological activity of 15-deoxy-Δ12,14-PGA2 at this time.  

     

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    Cayman
    SKU:10265 - 500 µg

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  • 15-deoxy-Δ12,14-PGD2 is a metabolite of PGD2 (Item No. 12010).{11797} It is an agonist of PGD2 receptor 2 (DP2) that binds DP2 (Ki = 50 nM for the mouse receptor expressed in HEK293 cell membranes) and induces activation of eosinophils (EC50 = 8 nM).{11399,11055} It also stimulates the recruitment of steroid receptor coactivator-1 (SRC-1) to peroxisome proliferator-activated receptor γ (PPARγ) and induces PPARγ-mediated transcription in a reporter assay when used at a concentration of 5 µM.{11797} 15-deoxy-Δ12,14-PGD2 is cytotoxic to L1210 murine leukemia cells (IC50 = 0.3 µg/ml).{1424} It inhibits ADP-induced platelet aggregation (IC50 = 320 ng/ml) less potently than PGD2.{1139}  

     

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    Cayman
    SKU:12700 - 1 mg

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  • 15-deoxy-Δ12,14-PGD2 is a metabolite of PGD2 (Item No. 12010).{11797} It is an agonist of PGD2 receptor 2 (DP2) that binds DP2 (Ki = 50 nM for the mouse receptor expressed in HEK293 cell membranes) and induces activation of eosinophils (EC50 = 8 nM).{11399,11055} It also stimulates the recruitment of steroid receptor coactivator-1 (SRC-1) to peroxisome proliferator-activated receptor γ (PPARγ) and induces PPARγ-mediated transcription in a reporter assay when used at a concentration of 5 µM.{11797} 15-deoxy-Δ12,14-PGD2 is cytotoxic to L1210 murine leukemia cells (IC50 = 0.3 µg/ml).{1424} It inhibits ADP-induced platelet aggregation (IC50 = 320 ng/ml) less potently than PGD2.{1139}  

     

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    Cayman
    SKU:12700 - 5 mg

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  • 15-deoxy-Δ12,14-PGD2 is a metabolite of PGD2 (Item No. 12010).{11797} It is an agonist of PGD2 receptor 2 (DP2) that binds DP2 (Ki = 50 nM for the mouse receptor expressed in HEK293 cell membranes) and induces activation of eosinophils (EC50 = 8 nM).{11399,11055} It also stimulates the recruitment of steroid receptor coactivator-1 (SRC-1) to peroxisome proliferator-activated receptor γ (PPARγ) and induces PPARγ-mediated transcription in a reporter assay when used at a concentration of 5 µM.{11797} 15-deoxy-Δ12,14-PGD2 is cytotoxic to L1210 murine leukemia cells (IC50 = 0.3 µg/ml).{1424} It inhibits ADP-induced platelet aggregation (IC50 = 320 ng/ml) less potently than PGD2.{1139}  

     

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    Cayman
    SKU:12700 - 500 µg

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  • 15-deoxy-Δ12,14-Prostaglandin J2 (15-deoxy-Δ12,14-PGJ2) is formed from PGD2 by the elimination of two molecules of water. It binds selectively to PPARγ with an EC50 value of 2 µM in a murine chimera system.{1428,1424} 15-deoxy-Δ12,14-PGJ2 is more potent than PGD2, Δ12-PGJ2, and PGJ2 in stimulating lipogenesis in C3H10T1/2 cells. The EC50 for induction of adipocyte differentiation in cultured fibroblasts is 7 µM.{1428}  

     

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  • This formulation of 15-deoxy-Δ12,14-PGJ2 contains 90-95% of the trans,trans-Δ12,14 isomer, and 5-10% of other double bond isomers which have similar PPARγ ligand activity (see Catalog No. 18570).  

     

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  • This formulation of 15-deoxy-Δ12,14-PGJ2 contains 90-95% of the trans,trans-Δ12,14 isomer, and 5-10% of other double bond isomers which have similar PPARγ ligand activity (see Catalog No. 18570).  

     

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    Cayman
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  • 15-deoxy-Δ12,14-Prostaglandin J2 (15-deoxy-Δ12,14-PGJ2) is formed from PGD2 by the elimination of two molecules of water. It binds selectively to PPARγ with an EC50 value of 2 µM in a murine chimera system.{1428,1424} 15-deoxy-Δ12,14-PGJ2 is more potent than PGD2, Δ12-PGJ2, and PGJ2 in stimulating lipogenesis in C3H10T1/2 cells. The EC50 for induction of adipocyte differentiation in cultured fibroblasts is 7 µM.{1428}  

     

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    Cayman
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  • 15-deoxy-Δ12,14-Prostaglandin J2 (15-deoxy-Δ12,14-PGJ2) is formed from PGD2 by the elimination of two molecules of water. It binds selectively to PPARγ with an EC50 value of 2 µM in a murine chimera system.{1428,1424} 15-deoxy-Δ12,14-PGJ2 is more potent than PGD2, Δ12-PGJ2, and PGJ2 in stimulating lipogenesis in C3H10T1/2 cells. The EC50 for induction of adipocyte differentiation in cultured fibroblasts is 7 µM.{1428}  

     

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    Cayman
    SKU:-

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  • This formulation of 15-deoxy-Δ12,14-PGJ2 contains 90-95% of the trans,trans-Δ12,14 isomer, and 5-10% of other double bond isomers which have similar PPARγ ligand activity (see Catalog No. 18570).  

     

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    Cayman
    SKU:-

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  • 15-deoxy-Δ12,14-Prostaglandin J2 (15-deoxy-Δ12,14-PGJ2) is formed from PGD2 by the elimination of two molecules of water. It binds selectively to PPARγ with an EC50 value of 2 µM in a murine chimera system.{1428,1424} 15-deoxy-Δ12,14-PGJ2 is more potent than PGD2, Δ12-PGJ2, and PGJ2 in stimulating lipogenesis in C3H10T1/2 cells. The EC50 for induction of adipocyte differentiation in cultured fibroblasts is 7 µM.{1428}  

     

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    Cayman
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  • 15-deoxy-Δ12,14-Prostaglandin J2 Glutathione (15-deoxy-Δ12,14-PGJ2 Glutathione) is a non-enzymatic adduct formed from 15-deoxy-Δ12,14-PGJ2 and glutathione.{10471,19705,19690} The biological properties of this compound have not been characterized.  

     

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    Cayman
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  • 15-deoxy-Δ12,14-Prostaglandin J2 Glutathione (15-deoxy-Δ12,14-PGJ2 Glutathione) is a non-enzymatic adduct formed from 15-deoxy-Δ12,14-PGJ2 and glutathione.{10471,19705,19690} The biological properties of this compound have not been characterized.  

     

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    Cayman
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  • 15-deoxy-Δ12,14-Prostaglandin J2 Glutathione (15-deoxy-Δ12,14-PGJ2 Glutathione) is a non-enzymatic adduct formed from 15-deoxy-Δ12,14-PGJ2 and glutathione.{10471,19705,19690} The biological properties of this compound have not been characterized.  

     

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    Cayman
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  • 15-deoxy-Δ12,14-Prostaglandin J2 (15-deoxy-Δ12,14-PGJ2) is formed from PGD2 (Item Nos. 12010 | 10007202) by the elimination of two molecules of water. It binds selectively to PPARγ with an EC50 value of 2 µM in a murine chimera system.{1428,1424} 15-deoxy-Δ12,14-PGJ2 is more potent than PGD2, Δ12-PGJ2 (Item Nos. 18550 | 10007234), and PGJ2 (Item Nos. 18500 | 10007233) in stimulating lipogenesis in C3H10T1/2 cells. The EC50 value for induction of adipocyte differentiation in cultured fibroblasts is 7 µM.{1428} 15-deoxy-Δ12,14-PGJ2 MaxSpec® standard is a quantitative grade standard of 15-deoxy-Δ12,14-PGJ2 (Item No. 18570) that has been prepared specifically for mass spectrometry or any application where quantitative reproducibility is required. The solution has been prepared gravimetrically and is supplied in a deactivated glass ampule sealed under argon. The concentration was verified by comparison to an independently prepared calibration standard. This 15-deoxy-Δ12,14-PGJ2 MaxSpec® standard is guaranteed to meet identity, purity, stability, and concentration specifications and is provided with a batch-specific certificate of analysis. Ongoing stability testing is performed to ensure the concentration remains accurate throughout the shelf life of the product. Note: The amount of solution added to the vial is in excess of the listed amount. Therefore, it is necessary to accurately measure volumes for preparation of calibration standards. Follow recommended storage and handling conditions to maintain product quality.  

     

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    SKU:10007235 - 100 µg

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  • 15-deoxy-Δ12,14-PGJ2-d4 contains four deuterium atoms at the 3, 3′, 4, and 4′ positions. It is intended for use as an internal standard for the quantification of 15-deoxy-Δ12,14-PGJ2 by GC- or LC-mass spectrometry. 15-deoxy-Δ12,14-Prostaglandin J2 (15-deoxy-Δ12,14-PGJ2) is a metabolite of PGJ2. 15-deoxy-Δ12,14-PGJ2 is formed from PGD2 by the elimination of two molecules of water. It binds selectively to PPARγ with an EC50 of 2 µM in a murine chimera system.{1424,1428} 15-deoxy-Δ12,14-PGJ2 is more potent than PGD2, Δ12-PGJ2, and PGJ2 in stimulating lipogenesis in C3H10T1/2 cells. The EC50 for induction of adipocyte differentiation in cultured fibroblasts is 7 µM.{1424}  

     

    Brand:
    Cayman
    SKU:318570 - 100 µg

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  • 15-deoxy-Δ12,14-PGJ2-d4 contains four deuterium atoms at the 3, 3′, 4, and 4′ positions. It is intended for use as an internal standard for the quantification of 15-deoxy-Δ12,14-PGJ2 by GC- or LC-mass spectrometry. 15-deoxy-Δ12,14-Prostaglandin J2 (15-deoxy-Δ12,14-PGJ2) is a metabolite of PGJ2. 15-deoxy-Δ12,14-PGJ2 is formed from PGD2 by the elimination of two molecules of water. It binds selectively to PPARγ with an EC50 of 2 µM in a murine chimera system.{1424,1428} 15-deoxy-Δ12,14-PGJ2 is more potent than PGD2, Δ12-PGJ2, and PGJ2 in stimulating lipogenesis in C3H10T1/2 cells. The EC50 for induction of adipocyte differentiation in cultured fibroblasts is 7 µM.{1424}  

     

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    Cayman
    SKU:318570 - 25 µg

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  • 15-deoxy-Δ12,14-PGJ2-d4 contains four deuterium atoms at the 3, 3′, 4, and 4′ positions. It is intended for use as an internal standard for the quantification of 15-deoxy-Δ12,14-PGJ2 by GC- or LC-mass spectrometry. 15-deoxy-Δ12,14-Prostaglandin J2 (15-deoxy-Δ12,14-PGJ2) is a metabolite of PGJ2. 15-deoxy-Δ12,14-PGJ2 is formed from PGD2 by the elimination of two molecules of water. It binds selectively to PPARγ with an EC50 of 2 µM in a murine chimera system.{1424,1428} 15-deoxy-Δ12,14-PGJ2 is more potent than PGD2, Δ12-PGJ2, and PGJ2 in stimulating lipogenesis in C3H10T1/2 cells. The EC50 for induction of adipocyte differentiation in cultured fibroblasts is 7 µM.{1424}  

     

    Brand:
    Cayman
    SKU:318570 - 50 µg

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  • Cayman’s 15-epi Lipoxin A4 (15-epi LXA4) ELISA Kit is a competitive assay that can be used for quantification of 15-epi LXA4 in plasma, serum, and urine. The assay has a range of 3.3-2,000 pg/ml and a sensitivity (80% B/B0) of approximately 16 pg/ml.  

     

    Brand:
    Cayman
    SKU:590415 - 96 solid well

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  • Cayman’s 15-epi Lipoxin A4 (15-epi LXA4) ELISA Kit is a competitive assay that can be used for quantification of 15-epi LXA4 in plasma, serum, and urine. The assay has a range of 3.3-2,000 pg/ml and a sensitivity (80% B/B0) of approximately 16 pg/ml.  

     

    Brand:
    Cayman
    SKU:590415 - 96 strip well

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  • 15-epi PGA1 is the 15(R) stereoisomer of PGA1. Prostaglandins of the A-series, including some with 15(R) stereochemistry, are natural products of gorgonian soft corals. PGA1 causes renal vasodilation, increased urine sodium excretion, and decreased arterial pressure in hypertensive patients.{410} There are no published reports on the biological activity of 15-epi PGA1 at this time.  

     

    Brand:
    Cayman
    SKU:10070 - 1 mg

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  • 15-epi PGA1 is the 15(R) stereoisomer of PGA1. Prostaglandins of the A-series, including some with 15(R) stereochemistry, are natural products of gorgonian soft corals. PGA1 causes renal vasodilation, increased urine sodium excretion, and decreased arterial pressure in hypertensive patients.{410} There are no published reports on the biological activity of 15-epi PGA1 at this time.  

     

    Brand:
    Cayman
    SKU:10070 - 100 µg

    Available on backorder

  • 15-epi PGA1 is the 15(R) stereoisomer of PGA1. Prostaglandins of the A-series, including some with 15(R) stereochemistry, are natural products of gorgonian soft corals. PGA1 causes renal vasodilation, increased urine sodium excretion, and decreased arterial pressure in hypertensive patients.{410} There are no published reports on the biological activity of 15-epi PGA1 at this time.  

     

    Brand:
    Cayman
    SKU:10070 - 500 µg

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  • 15-hydroxy Pentadecanoic acid is a hydroxylated fatty acid that has been used in the synthesis of the macrocyclic lactone musk compounds exaltolide and phoracantholide I.{36619} [Matreya, LLC. Catalog No. 1881]  

     

    Brand:
    Cayman
    SKU:24648 - 10 mg

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  • 15-hydroxy Pentadecanoic acid is a hydroxylated fatty acid that has been used in the synthesis of the macrocyclic lactone musk compounds exaltolide and phoracantholide I.{36619} [Matreya, LLC. Catalog No. 1881]  

     

    Brand:
    Cayman
    SKU:24648 - 25 mg

    Available on backorder

  • 15-hydroxy Pentadecanoic acid is a hydroxylated fatty acid that has been used in the synthesis of the macrocyclic lactone musk compounds exaltolide and phoracantholide I.{36619} [Matreya, LLC. Catalog No. 1881]  

     

    Brand:
    Cayman
    SKU:24648 - 5 mg

    Available on backorder