Cayman
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Hypoxic cells are low oxygen cells that when present in tumors are radioresistant and chemoresistant. Pimonidazole is a small molecule radiosensitizer that has proven to be an effective and nontoxic hypoxia marker for human squamous cell carcinomas of the cervix, head, and neck.{15586} This immunochemical hypoxia marker has been widely used in experimental and clinical studies due to its chemical stability, water solubility, and wide tissue distribution. It is generally administered in aqueous solution by injection.
Brand:CaymanSKU:89130 - 10 mgAvailable on backorder
Hypoxic cells are low oxygen cells that when present in tumors are radioresistant and chemoresistant. Pimonidazole is a small molecule radiosensitizer that has proven to be an effective and nontoxic hypoxia marker for human squamous cell carcinomas of the cervix, head, and neck.{15586} This immunochemical hypoxia marker has been widely used in experimental and clinical studies due to its chemical stability, water solubility, and wide tissue distribution. It is generally administered in aqueous solution by injection.
Brand:CaymanSKU:89130 - 100 mgAvailable on backorder
Hypoxic cells are low oxygen cells that when present in tumors are radioresistant and chemoresistant. Pimonidazole is a small molecule radiosensitizer that has proven to be an effective and nontoxic hypoxia marker for human squamous cell carcinomas of the cervix, head, and neck.{15586} This immunochemical hypoxia marker has been widely used in experimental and clinical studies due to its chemical stability, water solubility, and wide tissue distribution. It is generally administered in aqueous solution by injection.
Brand:CaymanSKU:89130 - 5 mgAvailable on backorder
Hypoxic cells are low oxygen cells that when present in tumors are radioresistant and chemoresistant. Pimonidazole is a small molecule radiosensitizer that has proven to be an effective and nontoxic hypoxia marker for human squamous cell carcinomas of the cervix, head, and neck.{15586} This immunochemical hypoxia marker has been widely used in experimental and clinical studies due to its chemical stability, water solubility, and wide tissue distribution. It is generally administered in aqueous solution by injection.
Brand:CaymanSKU:89130 - 50 mgAvailable on backorder
Pimozide is a dopamine receptor antagonist (Kis = 2.4, 0.3, and 1.8 nM for D2, D3, and D4 receptors, respectively).{25512} It also binds to eight additional receptors (Kds = 25-3,100 nM for the human receptors) and inhibits the voltage-gated sodium channel Nav1.2 and the voltage-gated potassium channel Kv11.1 (IC50s = 42 and 340 nM, respectively).{25511,26443,26441} Pimozide (0.5, 1, and 2 mg/kg) decreases the number of licks and reduces fluid intake of a sweetened solution in rats.{45613} It decreases the number of threats and attacks and increases immobility time in the neutral arena aggression test, indicating increased passiveness, in male mice when administered at a dose of 0.75 mg/kg for 10 days.{45614} Formulations containing pimozide have been used in the treatment of Tourette syndrome.
Brand:CaymanSKU:- Pimozide is a dopamine receptor antagonist (Kis = 2.4, 0.3, and 1.8 nM for D2, D3, and D4 receptors, respectively).{25512} It also binds to eight additional receptors (Kds = 25-3,100 nM for the human receptors) and inhibits the voltage-gated sodium channel Nav1.2 and the voltage-gated potassium channel Kv11.1 (IC50s = 42 and 340 nM, respectively).{25511,26443,26441} Pimozide (0.5, 1, and 2 mg/kg) decreases the number of licks and reduces fluid intake of a sweetened solution in rats.{45613} It decreases the number of threats and attacks and increases immobility time in the neutral arena aggression test, indicating increased passiveness, in male mice when administered at a dose of 0.75 mg/kg for 10 days.{45614} Formulations containing pimozide have been used in the treatment of Tourette syndrome.
Brand:CaymanSKU:- Pimozide is a dopamine receptor antagonist (Kis = 2.4, 0.3, and 1.8 nM for D2, D3, and D4 receptors, respectively).{25512} It also binds to eight additional receptors (Kds = 25-3,100 nM for the human receptors) and inhibits the voltage-gated sodium channel Nav1.2 and the voltage-gated potassium channel Kv11.1 (IC50s = 42 and 340 nM, respectively).{25511,26443,26441} Pimozide (0.5, 1, and 2 mg/kg) decreases the number of licks and reduces fluid intake of a sweetened solution in rats.{45613} It decreases the number of threats and attacks and increases immobility time in the neutral arena aggression test, indicating increased passiveness, in male mice when administered at a dose of 0.75 mg/kg for 10 days.{45614} Formulations containing pimozide have been used in the treatment of Tourette syndrome.
Brand:CaymanSKU:-
Pimozide-d4 is an internal standard for the quantification of pimozide (Item No. 16222) by GC- or LC-MS. Pimozide is a dopamine receptor antagonist (Kis = 2.4, 0.3, and 1.8 nM for D2, D3, and D4 receptors, respectively).{25512} It also binds to eight additional receptors (Kds = 25-3,100 nM for the human receptors) and inhibits the voltage-gated sodium channel Nav1.2 and the voltage-gated potassium channel Kv11.1 (IC50s = 42 and 340 nM, respectively).{25511,26443,26441} Pimozide (0.5, 1, and 2 mg/kg) decreases the number of licks and reduces fluid intake of a sweetened solution in rats.{45613} It decreases the number of threats and attacks and increases immobility time in the neutral arena aggression test, indicating increased passiveness, in male mice when administered at a dose of 0.75 mg/kg for 10 days.{45614} Formulations containing pimozide have been used in the treatment of Tourette syndrome.
Brand:CaymanSKU:28617 - 1 mgAvailable on backorder
Pimprinine is an alkaloid originally isolated from Streptomyces that has diverse biological activities, including anticonvulsant, antiplatelet, and antimicrobial properties.{36886,36887,36889,36888} It inhibits deamination of serotonin (5-HT; Item No. 14332) by monoamine oxidase (MAO; IC50 = 48 μM).{36886} Pimprinine (80 mg/kg) increases the minimum and maximum electroshock seizure thresholds in mice.{36887} In a mouse model of tremorine-induced tremors, it increases the latency to tremor onset, as well as reduces the intensity and duration of tremors and the analgesic activity of tremorine when administered at a dose of 80 mg/kg. Pimprinine inhibits aggregation of rabbit platelets induced by arachidonic acid (Item Nos. 90010 | 10006607) or collagen (IC50s = 3 and 25 μg/ml, respectively) and arachidonic acid-induced thromboxane A2 (TXA2) synthesis in rabbit platelets in vitro (IC50 = 6 μg/ml).{36889} It also inhibits the growth of M. tuberculosis, P. varioti, C. albicans, and S. lutea in vitro (MICs = 25, 1, 1.5, and 2.5 μg/ml, respectively).{36888,36887}
Brand:CaymanSKU:25507 - 1 mgAvailable on backorder
Pimprinine is an alkaloid originally isolated from Streptomyces that has diverse biological activities, including anticonvulsant, antiplatelet, and antimicrobial properties.{36886,36887,36889,36888} It inhibits deamination of serotonin (5-HT; Item No. 14332) by monoamine oxidase (MAO; IC50 = 48 μM).{36886} Pimprinine (80 mg/kg) increases the minimum and maximum electroshock seizure thresholds in mice.{36887} In a mouse model of tremorine-induced tremors, it increases the latency to tremor onset, as well as reduces the intensity and duration of tremors and the analgesic activity of tremorine when administered at a dose of 80 mg/kg. Pimprinine inhibits aggregation of rabbit platelets induced by arachidonic acid (Item Nos. 90010 | 10006607) or collagen (IC50s = 3 and 25 μg/ml, respectively) and arachidonic acid-induced thromboxane A2 (TXA2) synthesis in rabbit platelets in vitro (IC50 = 6 μg/ml).{36889} It also inhibits the growth of M. tuberculosis, P. varioti, C. albicans, and S. lutea in vitro (MICs = 25, 1, 1.5, and 2.5 μg/ml, respectively).{36888,36887}
Brand:CaymanSKU:25507 - 5 mgAvailable on backorder
Pinacidil is a cyanoguanidine compound that acts as a potassium channel opener, activating the ATP-modulated potassium channels of guinea pig bladder and heart with Ki values of 104 and 251 nM, respectively.{25813,25181,22674} It completely relaxes coronary artery rings preconstricted with serotonin (Item No. 14332; IC50 = 1.26 µM).{25180} Through this mechanism, pinacidil causes vascular relaxation, decreases peripheral vascular resistance, and reduces hypertension in animals and humans.{25812,25814}
Brand:CaymanSKU:- Pinacidil is a cyanoguanidine compound that acts as a potassium channel opener, activating the ATP-modulated potassium channels of guinea pig bladder and heart with Ki values of 104 and 251 nM, respectively.{25813,25181,22674} It completely relaxes coronary artery rings preconstricted with serotonin (Item No. 14332; IC50 = 1.26 µM).{25180} Through this mechanism, pinacidil causes vascular relaxation, decreases peripheral vascular resistance, and reduces hypertension in animals and humans.{25812,25814}
Brand:CaymanSKU:- Pinacidil is a cyanoguanidine compound that acts as a potassium channel opener, activating the ATP-modulated potassium channels of guinea pig bladder and heart with Ki values of 104 and 251 nM, respectively.{25813,25181,22674} It completely relaxes coronary artery rings preconstricted with serotonin (Item No. 14332; IC50 = 1.26 µM).{25180} Through this mechanism, pinacidil causes vascular relaxation, decreases peripheral vascular resistance, and reduces hypertension in animals and humans.{25812,25814}
Brand:CaymanSKU:- Pinacidil is a cyanoguanidine compound that acts as a potassium channel opener, activating the ATP-modulated potassium channels of guinea pig bladder and heart with Ki values of 104 and 251 nM, respectively.{25813,25181,22674} It completely relaxes coronary artery rings preconstricted with serotonin (Item No. 14332; IC50 = 1.26 µM).{25180} Through this mechanism, pinacidil causes vascular relaxation, decreases peripheral vascular resistance, and reduces hypertension in animals and humans.{25812,25814}
Brand:CaymanSKU:-
Pinane thromboxane A2 (PTA2) is a stable analog of TXA2. It is a TP receptor antagonist and an inhibitor of thromboxane synthase.{516,794} PTA2 inhibits U-46619-induced cat coronary artery constriction (ID50 = 0.1 µM), U-46619-induced aggregation of human platelets (IC50 = 2 µM), and rabbit platelet thromboxane synthase (ID50 = 50 µM). PTA2 does not affect PGI synthase up to a concentration of 100 µM.{516}
Brand:CaymanSKU:-Available on backorder
Pinane thromboxane A2 (PTA2) is a stable analog of TXA2. It is a TP receptor antagonist and an inhibitor of thromboxane synthase.{516,794} PTA2 inhibits U-46619-induced cat coronary artery constriction (ID50 = 0.1 µM), U-46619-induced aggregation of human platelets (IC50 = 2 µM), and rabbit platelet thromboxane synthase (ID50 = 50 µM). PTA2 does not affect PGI synthase up to a concentration of 100 µM.{516}
Brand:CaymanSKU:-Available on backorder
Pinane thromboxane A2 (PTA2) is a stable analog of TXA2. It is a TP receptor antagonist and an inhibitor of thromboxane synthase.{516,794} PTA2 inhibits U-46619-induced cat coronary artery constriction (ID50 = 0.1 µM), U-46619-induced aggregation of human platelets (IC50 = 2 µM), and rabbit platelet thromboxane synthase (ID50 = 50 µM). PTA2 does not affect PGI synthase up to a concentration of 100 µM.{516}
Brand:CaymanSKU:-Available on backorder
Pinane thromboxane A2 (PTA2) is a stable analog of TXA2. It is a TP receptor antagonist and an inhibitor of thromboxane synthase.{516,794} PTA2 inhibits U-46619-induced cat coronary artery constriction (ID50 = 0.1 µM), U-46619-induced aggregation of human platelets (IC50 = 2 µM), and rabbit platelet thromboxane synthase (ID50 = 50 µM). PTA2 does not affect PGI synthase up to a concentration of 100 µM.{516}
Brand:CaymanSKU:-Available on backorder
Pindolol is an antagonist of β1- and β2-adrenergic receptors (β1- and β2-ARs; Kis = 2.6 and 4.8 nM, respectively) and a partial agonist of the β3-AR, stimulating adenylyl cyclase in membranes of cells expressing the human receptor.{37170,25395} It is also an antagonist of the serotonin 5-HT1A receptor (Ki = 81.1 nM for inhibition of 5-HT-stimulated GTPγS binding).{39331} Pindolol inhibits isoproterenol-induced tachycardia in anesthetized cats (ED50 = 1.8 µg/kg).{37171} It also decreases mean blood pressure in conscious spontaneously hypertensive rats when administered at a dose of 30 mg/kg per day, but concomitantly increases heart rate.{41850} Formulations containing pindolol have been used in the treatment of hypertension.
Brand:CaymanSKU:21445 -Out of stock
Pindolol is an antagonist of β1- and β2-adrenergic receptors (β1- and β2-ARs; Kis = 2.6 and 4.8 nM, respectively) and a partial agonist of the β3-AR, stimulating adenylyl cyclase in membranes of cells expressing the human receptor.{37170,25395} It is also an antagonist of the serotonin 5-HT1A receptor (Ki = 81.1 nM for inhibition of 5-HT-stimulated GTPγS binding).{39331} Pindolol inhibits isoproterenol-induced tachycardia in anesthetized cats (ED50 = 1.8 µg/kg).{37171} It also decreases mean blood pressure in conscious spontaneously hypertensive rats when administered at a dose of 30 mg/kg per day, but concomitantly increases heart rate.{41850} Formulations containing pindolol have been used in the treatment of hypertension.
Brand:CaymanSKU:21445 -Out of stock
Pindolol is an antagonist of β1- and β2-adrenergic receptors (β1- and β2-ARs; Kis = 2.6 and 4.8 nM, respectively) and a partial agonist of the β3-AR, stimulating adenylyl cyclase in membranes of cells expressing the human receptor.{37170,25395} It is also an antagonist of the serotonin 5-HT1A receptor (Ki = 81.1 nM for inhibition of 5-HT-stimulated GTPγS binding).{39331} Pindolol inhibits isoproterenol-induced tachycardia in anesthetized cats (ED50 = 1.8 µg/kg).{37171} It also decreases mean blood pressure in conscious spontaneously hypertensive rats when administered at a dose of 30 mg/kg per day, but concomitantly increases heart rate.{41850} Formulations containing pindolol have been used in the treatment of hypertension.
Brand:CaymanSKU:21445 -Out of stock
Pindolol is an antagonist of β1- and β2-adrenergic receptors (β1- and β2-ARs; Kis = 2.6 and 4.8 nM, respectively) and a partial agonist of the β3-AR, stimulating adenylyl cyclase in membranes of cells expressing the human receptor.{37170,25395} It is also an antagonist of the serotonin 5-HT1A receptor (Ki = 81.1 nM for inhibition of 5-HT-stimulated GTPγS binding).{39331} Pindolol inhibits isoproterenol-induced tachycardia in anesthetized cats (ED50 = 1.8 µg/kg).{37171} It also decreases mean blood pressure in conscious spontaneously hypertensive rats when administered at a dose of 30 mg/kg per day, but concomitantly increases heart rate.{41850} Formulations containing pindolol have been used in the treatment of hypertension.
Brand:CaymanSKU:21445 -Out of stock
PTEN-induced putative kinase 1 (PINK1) is a serine/threonine protein kinase that has a role in mitochondrial function.{54198,54199} It is comprised of an N-terminal mitochondrial targeting sequence, a transmembrane domain, a serine/threonine kinase domain, and a C-terminal region.{54199} PINK1 is ubiquitously expressed primarily in the brain, skeletal muscle, and heart.{54200} It localizes to the mitochondria where it is either rapidly degraded or, under conditions of low mitochondrial membrane potential, accumulates on the outer mitochondrial membrane, where it recruits and activates the cytosolic E3 ubiquitin ligase Parkin, which targets the mitochondria for mitophagy.{54198,54200} Pink1 knockout in rats leads to an age-dependent loss of dopaminergic neurons in the substantia nigra, as well as deficits in motor function and mitochondrial respiration.{54201} In mice, Pink1 knockout does not induce a loss of dopaminergic neurons without concomitant overexpression of α-synuclein in the substantia nigra.{54202} Loss-of-function mutations in PINK1 are causally associated with autosomal recessive early-onset Parkinson’s disease.{54200,12321} Cayman’s PINK1 Monoclonal Antibody recognizes primarily the full length protein at about 66 kDa in human tissues. This antibody can be used for ELISA and Western blot applications.
Brand:CaymanSKU:29129 - 200 µgAvailable on backorder
Immunogen: Recombinant human PINK1 amino acids 156-511 • Host: Mouse • Species Reactivity: (+) Human, others not tested • Cross Reactivity: (+) PINK1 • Applications: ELISA, WB
Brand:CaymanSKU:29129- 200 µgAvailable on backorder
Immunogen: Recombinant human PINK1 amino acids 156-511 • Host: Mouse • Species Reactivity: (+) Human, others not tested • Cross Reactivity: (+) PINK1 • Applications: ELISA, WB
Brand:CaymanSKU:29129- 200 µg
Immunogen: Synthetic peptide from the C-terminal region of human PINK1 • Host: Rabbit • Species Reactivity: (+) Human, mouse, rat; other species not tested • Applications: IHC, WB • MW: 66 and 33 kDa for the full-length and truncated form, respectively
Brand:CaymanSKU:10006283- 1 eaAvailable on backorder
Immunogen: Synthetic peptide from the C-terminal region of human PINK1 • Host: Rabbit • Species Reactivity: (+) Human, mouse, rat; other species not tested • Applications: IHC, WB • MW: 66 and 33 kDa for the full-length and truncated form, respectively
Brand:CaymanSKU:10006283- 1 ea PTEN-induced putative kinase 1 (PINK1) is a serine/threonine protein kinase that has a role in mitochondrial function.{54198,54199} It is comprised of an N-terminal mitochondrial targeting sequence, a transmembrane domain, a serine/threonine kinase domain, and a C-terminal region.{54199} PINK1 is ubiquitously expressed primarily in the brain, skeletal muscle, and heart.{54200} It localizes to the mitochondria where it is either rapidly degraded or, under conditions of low mitochondrial membrane potential, accumulates on the outer mitochondrial membrane, where it recruits and activates the cytosolic E3 ubiquitin ligase Parkin, which targets the mitochondria for mitophagy.{54200,54198} Pink1 knockout in rats leads to an age-dependent loss of dopaminergic neurons in the substantia nigra, as well as deficits in motor function and mitochondrial respiration.{54201} In mice, Pink1 knockout does not induce a loss of dopaminergic neurons without concomitant overexpression of α-synuclein in the substantia nigra.{54202} Loss-of-function mutations in PINK1 are causally associated with autosomal recessive early-onset Parkinson’s disease.{54200,12321} Cayman’s PINK1 Polyclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications. The antibody primarily recognizes full-length PINK1 at approximately 66 kDa from human, mouse, and rat samples but also detects a truncated form of the protein at approximately 33 kDa.
Brand:CaymanSKU:10006283 - 1 eaAvailable on backorder
Pinocembrin is a flavonoid that has been found in Eucalyptus, and has diverse biological activities.{52452,52453,52454,52455,52456} It induces apoptosis in, and inhibits the migration of, SKOV3 ovarian cancer cells when used at a concentration of 200 µM.{52453} Pinocembrin (5 mg/kg) reduces lesion volume, as well as brain microglial activation and production of IL-1β, IL-6, and TNF-α in a mouse model of collagenase-induced intracerebral hemorrhage (ICH).{52454} It prevents increases in plasma and kidney malondialdehyde (MDA) levels, glomeruli lobulation, mesangial expansion, and tubule vacuolization and occlusion, and it decreases hepatic cholesterol, triglyceride, and LDL levels in a rat model of diabetic nephropathy.{52455} Pinocembrin (20 and 50 mg/kg) reduces pulmonary edema, as well as neutrophil, lymphocyte, and macrophage infiltration in a mouse model of LPS-induced lung injury.{52456}
Brand:CaymanSKU:29852 - 10 mgAvailable on backorder
Pinocembrin is a flavonoid that has been found in Eucalyptus, and has diverse biological activities.{52452,52453,52454,52455,52456} It induces apoptosis in, and inhibits the migration of, SKOV3 ovarian cancer cells when used at a concentration of 200 µM.{52453} Pinocembrin (5 mg/kg) reduces lesion volume, as well as brain microglial activation and production of IL-1β, IL-6, and TNF-α in a mouse model of collagenase-induced intracerebral hemorrhage (ICH).{52454} It prevents increases in plasma and kidney malondialdehyde (MDA) levels, glomeruli lobulation, mesangial expansion, and tubule vacuolization and occlusion, and it decreases hepatic cholesterol, triglyceride, and LDL levels in a rat model of diabetic nephropathy.{52455} Pinocembrin (20 and 50 mg/kg) reduces pulmonary edema, as well as neutrophil, lymphocyte, and macrophage infiltration in a mouse model of LPS-induced lung injury.{52456}
Brand:CaymanSKU:29852 - 100 mgAvailable on backorder
Pinocembrin is a flavonoid that has been found in Eucalyptus, and has diverse biological activities.{52452,52453,52454,52455,52456} It induces apoptosis in, and inhibits the migration of, SKOV3 ovarian cancer cells when used at a concentration of 200 µM.{52453} Pinocembrin (5 mg/kg) reduces lesion volume, as well as brain microglial activation and production of IL-1β, IL-6, and TNF-α in a mouse model of collagenase-induced intracerebral hemorrhage (ICH).{52454} It prevents increases in plasma and kidney malondialdehyde (MDA) levels, glomeruli lobulation, mesangial expansion, and tubule vacuolization and occlusion, and it decreases hepatic cholesterol, triglyceride, and LDL levels in a rat model of diabetic nephropathy.{52455} Pinocembrin (20 and 50 mg/kg) reduces pulmonary edema, as well as neutrophil, lymphocyte, and macrophage infiltration in a mouse model of LPS-induced lung injury.{52456}
Brand:CaymanSKU:29852 - 250 mgAvailable on backorder
Pinocembrin is a flavonoid that has been found in Eucalyptus, and has diverse biological activities.{52452,52453,52454,52455,52456} It induces apoptosis in, and inhibits the migration of, SKOV3 ovarian cancer cells when used at a concentration of 200 µM.{52453} Pinocembrin (5 mg/kg) reduces lesion volume, as well as brain microglial activation and production of IL-1β, IL-6, and TNF-α in a mouse model of collagenase-induced intracerebral hemorrhage (ICH).{52454} It prevents increases in plasma and kidney malondialdehyde (MDA) levels, glomeruli lobulation, mesangial expansion, and tubule vacuolization and occlusion, and it decreases hepatic cholesterol, triglyceride, and LDL levels in a rat model of diabetic nephropathy.{52455} Pinocembrin (20 and 50 mg/kg) reduces pulmonary edema, as well as neutrophil, lymphocyte, and macrophage infiltration in a mouse model of LPS-induced lung injury.{52456}
Brand:CaymanSKU:29852 - 50 mgAvailable on backorder
Pinolenic acid is a polyunsaturated fatty acid found in Korean pine (Pinus orientalis) and maritime pine (Pinus pinaster) seed oils. Both oils have been found to have lipid-lowering properties. A diet containing maritime pine seed oil (MPSO) lowered HDL and ApoA1 levels in transgenic mice expressing human ApoA1. MPSO was found to diminish cholesterol efflux in vitro.{14273} Korean pine seed oil supplements may help in obesity by reduction of appetite. People taking this oil had an increase in the satiety hormones CCK and GLP-1 and a reduced desire to eat.{14280} The activity of the oil is attributed to pinolenic acid. Pinolenic acid is not converted to arachidonic acid metabolically and can reduce arachidonic acid levels in the phosphatidylinositol fraction of HepG2 cells from 15.9% to 7.0%.{8724}
Brand:CaymanSKU:10008654 - 10 mgAvailable on backorder
Pinolenic acid is a polyunsaturated fatty acid found in Korean pine (Pinus orientalis) and maritime pine (Pinus pinaster) seed oils. Both oils have been found to have lipid-lowering properties. A diet containing maritime pine seed oil (MPSO) lowered HDL and ApoA1 levels in transgenic mice expressing human ApoA1. MPSO was found to diminish cholesterol efflux in vitro.{14273} Korean pine seed oil supplements may help in obesity by reduction of appetite. People taking this oil had an increase in the satiety hormones CCK and GLP-1 and a reduced desire to eat.{14280} The activity of the oil is attributed to pinolenic acid. Pinolenic acid is not converted to arachidonic acid metabolically and can reduce arachidonic acid levels in the phosphatidylinositol fraction of HepG2 cells from 15.9% to 7.0%.{8724}
Brand:CaymanSKU:10008654 - 100 mgAvailable on backorder
Pinolenic acid is a polyunsaturated fatty acid found in Korean pine (Pinus orientalis) and maritime pine (Pinus pinaster) seed oils. Both oils have been found to have lipid-lowering properties. A diet containing maritime pine seed oil (MPSO) lowered HDL and ApoA1 levels in transgenic mice expressing human ApoA1. MPSO was found to diminish cholesterol efflux in vitro.{14273} Korean pine seed oil supplements may help in obesity by reduction of appetite. People taking this oil had an increase in the satiety hormones CCK and GLP-1 and a reduced desire to eat.{14280} The activity of the oil is attributed to pinolenic acid. Pinolenic acid is not converted to arachidonic acid metabolically and can reduce arachidonic acid levels in the phosphatidylinositol fraction of HepG2 cells from 15.9% to 7.0%.{8724}
Brand:CaymanSKU:10008654 - 25 mgAvailable on backorder
Pinolenic acid is a polyunsaturated fatty acid found in Korean pine (Pinus orientalis) and maritime pine (Pinus pinaster) seed oils. Both oils have been found to have lipid-lowering properties. A diet containing maritime pine seed oil (MPSO) lowered HDL and ApoA1 levels in transgenic mice expressing human ApoA1. MPSO was found to diminish cholesterol efflux in vitro.{14273} Korean pine seed oil supplements may help in obesity by reduction of appetite. People taking this oil had an increase in the satiety hormones CCK and GLP-1 and a reduced desire to eat.{14280} The activity of the oil is attributed to pinolenic acid. Pinolenic acid is not converted to arachidonic acid metabolically and can reduce arachidonic acid levels in the phosphatidylinositol fraction of HepG2 cells from 15.9% to 7.0%.{8724}
Brand:CaymanSKU:10008654 - 50 mgAvailable on backorder
Pinolenic acid is a polyunsaturated fatty acid found in Korean pine (Pinus orientalis) and maritime pine (Pinus pinaster) seed oils. Both oils have been found to have lipid-lowering properties. A diet containing maritime pine seed oil (MPSO) lowered high-density lipoprotein and ApoA1 levels in transgenic mice expressing human ApoA1. MPSO was found to diminish cholesterol efflux in vitro.{14273} Korean pine seed oil supplements may help in obesity by reduction of appetite. People taking this oil had an increase in the satiety hormones CCK and GLP-1 and a reduced desire to eat.{14280} The activity of the oil is attributed to pinolenic acid. Pinolenic acid is not converted to arachidonic acid metabolically and can reduce arachidonic acid levels in the phosphatidylinositol fraction of HepG2 cells from 15.9% to 7.0%.{8724} Pinolenic acid ethyl ester is a neutral, more lipophilic form of the free acid.
Brand:CaymanSKU:10008658 - 10 mgAvailable on backorder
Pinolenic acid is a polyunsaturated fatty acid found in Korean pine (Pinus orientalis) and maritime pine (Pinus pinaster) seed oils. Both oils have been found to have lipid-lowering properties. A diet containing maritime pine seed oil (MPSO) lowered high-density lipoprotein and ApoA1 levels in transgenic mice expressing human ApoA1. MPSO was found to diminish cholesterol efflux in vitro.{14273} Korean pine seed oil supplements may help in obesity by reduction of appetite. People taking this oil had an increase in the satiety hormones CCK and GLP-1 and a reduced desire to eat.{14280} The activity of the oil is attributed to pinolenic acid. Pinolenic acid is not converted to arachidonic acid metabolically and can reduce arachidonic acid levels in the phosphatidylinositol fraction of HepG2 cells from 15.9% to 7.0%.{8724} Pinolenic acid ethyl ester is a neutral, more lipophilic form of the free acid.
Brand:CaymanSKU:10008658 - 5 mgAvailable on backorder
Pinolenic acid is a polyunsaturated fatty acid found in Korean pine (Pinus orientalis) and maritime pine (Pinus pinaster) seed oils. Both oils have been found to have lipid-lowering properties. A diet containing maritime pine seed oil (MPSO) lowered high-density lipoprotein and ApoA1 levels in transgenic mice expressing human ApoA1. MPSO was found to diminish cholesterol efflux in vitro.{14273} Korean pine seed oil supplements may help in obesity by reduction of appetite. People taking this oil had an increase in the satiety hormones CCK and GLP-1 and a reduced desire to eat.{14280} The activity of the oil is attributed to pinolenic acid. Pinolenic acid is not converted to arachidonic acid metabolically and can reduce arachidonic acid levels in the phosphatidylinositol fraction of HepG2 cells from 15.9% to 7.0%.{8724} Pinolenic acid ethyl ester is a neutral, more lipophilic form of the free acid.
Brand:CaymanSKU:10008658 - 50 mgAvailable on backorder
Pinolenic acid is a polyunsaturated fatty acid found in Korean pine (Pinus orientalis) and maritime pine (Pinus pinaster) seed oils. Both oils have been found to have lipid-lowering properties. A diet containing maritime pine seed oil (MPSO) lowered HDL and ApoA-I levels in transgenic mice expressing human ApoA-I. MPSO was found to diminish cholesterol efflux in vitro.{14273} Korean pine seed oil supplements may help in obesity by reduction of appetite. People taking this oil had an increase in the satiety hormones CCK and GLP-1 and a reduced desire to eat.{14280} The activity of the oil is attributed to pinolenic acid. Due to the non-methylene-interrupted double bond at the Δ5 position, pinolenic acid is not converted to arachidonic acid metabolically. Pinoleic acid can reduce arachidonic acid levels in the phosphatidylinositol fraction of Hep-G2 cells from 15.9% to 7.0%.{8724} Pinolenic acid methyl ester is a neutral, more lipophilic form of the free acid.
Brand:CaymanSKU:10008656 - 1 mgAvailable on backorder
Pinolenic acid is a polyunsaturated fatty acid found in Korean pine (Pinus orientalis) and maritime pine (Pinus pinaster) seed oils. Both oils have been found to have lipid-lowering properties. A diet containing maritime pine seed oil (MPSO) lowered HDL and ApoA-I levels in transgenic mice expressing human ApoA-I. MPSO was found to diminish cholesterol efflux in vitro.{14273} Korean pine seed oil supplements may help in obesity by reduction of appetite. People taking this oil had an increase in the satiety hormones CCK and GLP-1 and a reduced desire to eat.{14280} The activity of the oil is attributed to pinolenic acid. Due to the non-methylene-interrupted double bond at the Δ5 position, pinolenic acid is not converted to arachidonic acid metabolically. Pinoleic acid can reduce arachidonic acid levels in the phosphatidylinositol fraction of Hep-G2 cells from 15.9% to 7.0%.{8724} Pinolenic acid methyl ester is a neutral, more lipophilic form of the free acid.
Brand:CaymanSKU:10008656 - 10 mgAvailable on backorder
Pinolenic acid is a polyunsaturated fatty acid found in Korean pine (Pinus orientalis) and maritime pine (Pinus pinaster) seed oils. Both oils have been found to have lipid-lowering properties. A diet containing maritime pine seed oil (MPSO) lowered HDL and ApoA-I levels in transgenic mice expressing human ApoA-I. MPSO was found to diminish cholesterol efflux in vitro.{14273} Korean pine seed oil supplements may help in obesity by reduction of appetite. People taking this oil had an increase in the satiety hormones CCK and GLP-1 and a reduced desire to eat.{14280} The activity of the oil is attributed to pinolenic acid. Due to the non-methylene-interrupted double bond at the Δ5 position, pinolenic acid is not converted to arachidonic acid metabolically. Pinoleic acid can reduce arachidonic acid levels in the phosphatidylinositol fraction of Hep-G2 cells from 15.9% to 7.0%.{8724} Pinolenic acid methyl ester is a neutral, more lipophilic form of the free acid.
Brand:CaymanSKU:10008656 - 5 mgAvailable on backorder
Pinolenic acid is a polyunsaturated fatty acid found in Korean pine (Pinus orientalis) and maritime pine (Pinus pinaster) seed oils. Both oils have been found to have lipid-lowering properties. A diet containing maritime pine seed oil (MPSO) lowered HDL and ApoA-I levels in transgenic mice expressing human ApoA-I. MPSO was found to diminish cholesterol efflux in vitro.{14273} Korean pine seed oil supplements may help in obesity by reduction of appetite. People taking this oil had an increase in the satiety hormones CCK and GLP-1 and a reduced desire to eat.{14280} The activity of the oil is attributed to pinolenic acid. Due to the non-methylene-interrupted double bond at the Δ5 position, pinolenic acid is not converted to arachidonic acid metabolically. Pinoleic acid can reduce arachidonic acid levels in the phosphatidylinositol fraction of Hep-G2 cells from 15.9% to 7.0%.{8724} Pinolenic acid methyl ester is a neutral, more lipophilic form of the free acid.
Brand:CaymanSKU:10008656 - 50 mgAvailable on backorder
Pinoresinol diglucoside is a lignan that has been found in E. ulmoides and has diverse biological activities.{51136,51137,51138} It inhibits peroxidation of a linoleic acid emulsion by 64.2% when used at a concentration of 20 μg/ml, scavenges hydrogen peroxide and 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805), ABTS (Item No. 27317), and superoxide anion free radicals, and has ferrous ion metal chelating activity in cell-free assays.{51136} In vivo, pinoresinol diglucoside (10, 20, and 40 mg/kg) inhibits increases in serum levels of inorganic phosphate, IL-6, and TNF-α and decreases in serum calcium levels and transverse diameter, weight, bone mineral content, and bone mineral density of the right femur in a rat model of osteoporosis induced by dexamethasone (Item No. 11015).{51138}
Brand:CaymanSKU:27708 - 10 mgAvailable on backorder
Pinoresinol diglucoside is a lignan that has been found in E. ulmoides and has diverse biological activities.{51136,51137,51138} It inhibits peroxidation of a linoleic acid emulsion by 64.2% when used at a concentration of 20 μg/ml, scavenges hydrogen peroxide and 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805), ABTS (Item No. 27317), and superoxide anion free radicals, and has ferrous ion metal chelating activity in cell-free assays.{51136} In vivo, pinoresinol diglucoside (10, 20, and 40 mg/kg) inhibits increases in serum levels of inorganic phosphate, IL-6, and TNF-α and decreases in serum calcium levels and transverse diameter, weight, bone mineral content, and bone mineral density of the right femur in a rat model of osteoporosis induced by dexamethasone (Item No. 11015).{51138}
Brand:CaymanSKU:27708 - 25 mgAvailable on backorder
Pinoresinol diglucoside is a lignan that has been found in E. ulmoides and has diverse biological activities.{51136,51137,51138} It inhibits peroxidation of a linoleic acid emulsion by 64.2% when used at a concentration of 20 μg/ml, scavenges hydrogen peroxide and 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805), ABTS (Item No. 27317), and superoxide anion free radicals, and has ferrous ion metal chelating activity in cell-free assays.{51136} In vivo, pinoresinol diglucoside (10, 20, and 40 mg/kg) inhibits increases in serum levels of inorganic phosphate, IL-6, and TNF-α and decreases in serum calcium levels and transverse diameter, weight, bone mineral content, and bone mineral density of the right femur in a rat model of osteoporosis induced by dexamethasone (Item No. 11015).{51138}
Brand:CaymanSKU:27708 - 5 mgAvailable on backorder
Pinoresinol diglucoside is a lignan that has been found in E. ulmoides and has diverse biological activities.{51136,51137,51138} It inhibits peroxidation of a linoleic acid emulsion by 64.2% when used at a concentration of 20 μg/ml, scavenges hydrogen peroxide and 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805), ABTS (Item No. 27317), and superoxide anion free radicals, and has ferrous ion metal chelating activity in cell-free assays.{51136} In vivo, pinoresinol diglucoside (10, 20, and 40 mg/kg) inhibits increases in serum levels of inorganic phosphate, IL-6, and TNF-α and decreases in serum calcium levels and transverse diameter, weight, bone mineral content, and bone mineral density of the right femur in a rat model of osteoporosis induced by dexamethasone (Item No. 11015).{51138}
Brand:CaymanSKU:27708 - 50 mgAvailable on backorder
Pinostilbene is a stable, monomethoxylated resveratrol derivative with enhanced bioavailability compared to resveratrol.{22054} At 0.1-10 μM pinostilbene reduces neurotoxicity in SH-SY5Y cells induced by the parkinsonian mimetic 6-hydroxydopamine and scavenges 2,2-diphenyl-1-picrylhydrazyl radicals with an IC50 value of 47.1 μM.{22055}
Brand:CaymanSKU:- Pinostilbene is a stable, monomethoxylated resveratrol derivative with enhanced bioavailability compared to resveratrol.{22054} At 0.1-10 μM pinostilbene reduces neurotoxicity in SH-SY5Y cells induced by the parkinsonian mimetic 6-hydroxydopamine and scavenges 2,2-diphenyl-1-picrylhydrazyl radicals with an IC50 value of 47.1 μM.{22055}
Brand:CaymanSKU:- Pinostilbene is a stable, monomethoxylated resveratrol derivative with enhanced bioavailability compared to resveratrol.{22054} At 0.1-10 μM pinostilbene reduces neurotoxicity in SH-SY5Y cells induced by the parkinsonian mimetic 6-hydroxydopamine and scavenges 2,2-diphenyl-1-picrylhydrazyl radicals with an IC50 value of 47.1 μM.{22055}
Brand:CaymanSKU:- Pinostilbene is a stable, monomethoxylated resveratrol derivative with enhanced bioavailability compared to resveratrol.{22054} At 0.1-10 μM pinostilbene reduces neurotoxicity in SH-SY5Y cells induced by the parkinsonian mimetic 6-hydroxydopamine and scavenges 2,2-diphenyl-1-picrylhydrazyl radicals with an IC50 value of 47.1 μM.{22055}
Brand:CaymanSKU:-
Pinostrobin is a flavonoid with diverse biological activities, including antioxidant, anti-inflammatory, and anticancer properties.{37107} It induces quinone reductase (QR) in murine hepatoma cells with a QR doubling concentration of 500 nM.{37108} Pinostrobin inhibits TNF-α and IL-1β production in RAW 264.7 macrophages (IC50s = 17.28 and 23.5 μM, respectively) and in LPS-stimulated rats (48.6 and 55% reduction, respectively).{37109} Pinostrobin also shows selective cytotoxicity for CCRF-CEM leukemia cells (IC50 = 10.2 μM) in a panel of eight cancer cell lines (IC50s = >30 μM).{37110}
Brand:CaymanSKU:22436 -Out of stock
Pinostrobin is a flavonoid with diverse biological activities, including antioxidant, anti-inflammatory, and anticancer properties.{37107} It induces quinone reductase (QR) in murine hepatoma cells with a QR doubling concentration of 500 nM.{37108} Pinostrobin inhibits TNF-α and IL-1β production in RAW 264.7 macrophages (IC50s = 17.28 and 23.5 μM, respectively) and in LPS-stimulated rats (48.6 and 55% reduction, respectively).{37109} Pinostrobin also shows selective cytotoxicity for CCRF-CEM leukemia cells (IC50 = 10.2 μM) in a panel of eight cancer cell lines (IC50s = >30 μM).{37110}
Brand:CaymanSKU:22436 -Out of stock
Pinostrobin is a flavonoid with diverse biological activities, including antioxidant, anti-inflammatory, and anticancer properties.{37107} It induces quinone reductase (QR) in murine hepatoma cells with a QR doubling concentration of 500 nM.{37108} Pinostrobin inhibits TNF-α and IL-1β production in RAW 264.7 macrophages (IC50s = 17.28 and 23.5 μM, respectively) and in LPS-stimulated rats (48.6 and 55% reduction, respectively).{37109} Pinostrobin also shows selective cytotoxicity for CCRF-CEM leukemia cells (IC50 = 10.2 μM) in a panel of eight cancer cell lines (IC50s = >30 μM).{37110}
Brand:CaymanSKU:22436 -Out of stock
Pinosylvin is a stilbene originally isolated from pine heartwood that has diverse biological activities.{51006,51007,51008,51009,51010,51011} It activates sirtuin 1 (SIRT1) and induces glucose uptake in isolated rat L6 skeletal muscle myotubes.{51007} Pinosylvin reduces radial growth in a panel of 28 plant pathogenic fungi when used at a concentration of 100 μg/ml.{51008} It reduces expression of matrix metalloproteinase-2 (MMP-2), MMP-9, and membrane type 1-MMP in and inhibits migration of HT-1080 cells.{51009} Pinosylvin (10 mg/kg, i.p.) reduces the number of tumor nodules and lung tumor weight in a CT26 mouse xenograft model of metastatic colon cancer. It decreases hind paw volume and myeloperoxidase (MPO) activity in a rat model of adjuvant-induced arthritis.{51010} Pinosylvin also exhibits plant antifeedant activity against L. americanus (snowshoe hares).{51011}
Brand:CaymanSKU:27612 - 1 mgAvailable on backorder
Pinosylvin is a stilbene originally isolated from pine heartwood that has diverse biological activities.{51006,51007,51008,51009,51010,51011} It activates sirtuin 1 (SIRT1) and induces glucose uptake in isolated rat L6 skeletal muscle myotubes.{51007} Pinosylvin reduces radial growth in a panel of 28 plant pathogenic fungi when used at a concentration of 100 μg/ml.{51008} It reduces expression of matrix metalloproteinase-2 (MMP-2), MMP-9, and membrane type 1-MMP in and inhibits migration of HT-1080 cells.{51009} Pinosylvin (10 mg/kg, i.p.) reduces the number of tumor nodules and lung tumor weight in a CT26 mouse xenograft model of metastatic colon cancer. It decreases hind paw volume and myeloperoxidase (MPO) activity in a rat model of adjuvant-induced arthritis.{51010} Pinosylvin also exhibits plant antifeedant activity against L. americanus (snowshoe hares).{51011}
Brand:CaymanSKU:27612 - 10 mgAvailable on backorder
Pinosylvin is a stilbene originally isolated from pine heartwood that has diverse biological activities.{51006,51007,51008,51009,51010,51011} It activates sirtuin 1 (SIRT1) and induces glucose uptake in isolated rat L6 skeletal muscle myotubes.{51007} Pinosylvin reduces radial growth in a panel of 28 plant pathogenic fungi when used at a concentration of 100 μg/ml.{51008} It reduces expression of matrix metalloproteinase-2 (MMP-2), MMP-9, and membrane type 1-MMP in and inhibits migration of HT-1080 cells.{51009} Pinosylvin (10 mg/kg, i.p.) reduces the number of tumor nodules and lung tumor weight in a CT26 mouse xenograft model of metastatic colon cancer. It decreases hind paw volume and myeloperoxidase (MPO) activity in a rat model of adjuvant-induced arthritis.{51010} Pinosylvin also exhibits plant antifeedant activity against L. americanus (snowshoe hares).{51011}
Brand:CaymanSKU:27612 - 25 mgAvailable on backorder
Pinosylvin is a stilbene originally isolated from pine heartwood that has diverse biological activities.{51006,51007,51008,51009,51010,51011} It activates sirtuin 1 (SIRT1) and induces glucose uptake in isolated rat L6 skeletal muscle myotubes.{51007} Pinosylvin reduces radial growth in a panel of 28 plant pathogenic fungi when used at a concentration of 100 μg/ml.{51008} It reduces expression of matrix metalloproteinase-2 (MMP-2), MMP-9, and membrane type 1-MMP in and inhibits migration of HT-1080 cells.{51009} Pinosylvin (10 mg/kg, i.p.) reduces the number of tumor nodules and lung tumor weight in a CT26 mouse xenograft model of metastatic colon cancer. It decreases hind paw volume and myeloperoxidase (MPO) activity in a rat model of adjuvant-induced arthritis.{51010} Pinosylvin also exhibits plant antifeedant activity against L. americanus (snowshoe hares).{51011}
Brand:CaymanSKU:27612 - 5 mgAvailable on backorder
Pioglitazone is an agonist of the peroxisome proliferator-activated receptor γ (PPARγ; EC50 = ~500-600 nM for both human and murine PPARγ).{10857,10670} It is selective for PPARγ over PPARα, exhibiting low level activation of PPARα at 1 µM and 5.4-fold activation at a concentration of 10 µM.{10857} Pioglitazone inhibits pyruvate oxidation and glucose production in hepatocytes when used at a concentration of 10 μM.{37440} In vivo, pioglitazone (0.3-3 mg/kg per day) reduces hyperglycemia, hyperlipidemia, and hyperinsulinemia in a dose-dependent manner in male Wistar fatty rats.{37441} It reduces the number of lesions in a transgenic rat adenocarcinoma of prostate (TRAP) model.{37442} Pioglitazone (2.5 mg/kg) also decreases production of neuroinflammatory cytokines and reduces immobility in the forced swim and tail suspension tests in a mouse model of chronic mild stress, indicating antidepressant-like activity that can be reversed by the PPARγ antagonist GW9662 (Item No. 70785).{37443}
Brand:CaymanSKU:71745 - 1 mgAvailable on backorder
Pioglitazone is an agonist of the peroxisome proliferator-activated receptor γ (PPARγ; EC50 = ~500-600 nM for both human and murine PPARγ).{10857,10670} It is selective for PPARγ over PPARα, exhibiting low level activation of PPARα at 1 µM and 5.4-fold activation at a concentration of 10 µM.{10857} Pioglitazone inhibits pyruvate oxidation and glucose production in hepatocytes when used at a concentration of 10 μM.{37440} In vivo, pioglitazone (0.3-3 mg/kg per day) reduces hyperglycemia, hyperlipidemia, and hyperinsulinemia in a dose-dependent manner in male Wistar fatty rats.{37441} It reduces the number of lesions in a transgenic rat adenocarcinoma of prostate (TRAP) model.{37442} Pioglitazone (2.5 mg/kg) also decreases production of neuroinflammatory cytokines and reduces immobility in the forced swim and tail suspension tests in a mouse model of chronic mild stress, indicating antidepressant-like activity that can be reversed by the PPARγ antagonist GW9662 (Item No. 70785).{37443}
Brand:CaymanSKU:71745 - 25 mgAvailable on backorder
Pioglitazone is an agonist of the peroxisome proliferator-activated receptor γ (PPARγ; EC50 = ~500-600 nM for both human and murine PPARγ).{10857,10670} It is selective for PPARγ over PPARα, exhibiting low level activation of PPARα at 1 µM and 5.4-fold activation at a concentration of 10 µM.{10857} Pioglitazone inhibits pyruvate oxidation and glucose production in hepatocytes when used at a concentration of 10 μM.{37440} In vivo, pioglitazone (0.3-3 mg/kg per day) reduces hyperglycemia, hyperlipidemia, and hyperinsulinemia in a dose-dependent manner in male Wistar fatty rats.{37441} It reduces the number of lesions in a transgenic rat adenocarcinoma of prostate (TRAP) model.{37442} Pioglitazone (2.5 mg/kg) also decreases production of neuroinflammatory cytokines and reduces immobility in the forced swim and tail suspension tests in a mouse model of chronic mild stress, indicating antidepressant-like activity that can be reversed by the PPARγ antagonist GW9662 (Item No. 70785).{37443}
Brand:CaymanSKU:71745 - 5 mgAvailable on backorder
Pioglitazone is an agonist of the peroxisome proliferator-activated receptor γ (PPARγ; EC50 = ~500-600 nM for both human and murine PPARγ).{10857,10670} It is selective for PPARγ over PPARα, exhibiting low level activation of PPARα at 1 µM and 5.4-fold activation at a concentration of 10 µM.{10857} Pioglitazone inhibits pyruvate oxidation and glucose production in hepatocytes when used at a concentration of 10 μM.{37440} In vivo, pioglitazone (0.3-3 mg/kg per day) reduces hyperglycemia, hyperlipidemia, and hyperinsulinemia in a dose-dependent manner in male Wistar fatty rats.{37441} It reduces the number of lesions in a transgenic rat adenocarcinoma of prostate (TRAP) model.{37442} Pioglitazone (2.5 mg/kg) also decreases production of neuroinflammatory cytokines and reduces immobility in the forced swim and tail suspension tests in a mouse model of chronic mild stress, indicating antidepressant-like activity that can be reversed by the PPARγ antagonist GW9662 (Item No. 70785).{37443}
Brand:CaymanSKU:71745 - 50 mgAvailable on backorder
Pioglitazone is an agonist of the peroxisome proliferator-activated receptor γ (PPARγ; EC50 = ~500-600 nM for both human and murine PPARγ).{10857,10670} It is selective for PPARγ over PPARα, exhibiting low level activation of PPARα at 1 µM and 5.4-fold activation at a concentration of 10 µM.{10857} Pioglitazone inhibits pyruvate oxidation and glucose production in hepatocytes when used at a concentration of 10 μM.{37440} In vivo, pioglitazone (0.3-3 mg/kg per day) reduces hyperglycemia, hyperlipidemia, and hyperinsulinemia in a dose-dependent manner in male Wistar fatty rats.{37441} It reduces the number of lesions in a transgenic rat adenocarcinoma of prostate (TRAP) model.{37442} Pioglitazone (2.5 mg/kg) also decreases production of neuroinflammatory cytokines and reduces immobility in the forced swim and tail suspension tests in a mouse model of chronic mild stress, indicating antidepressant-like activity that can be reversed by the PPARγ antagonist GW 9662 (Item No. 70785).{37443}
Brand:CaymanSKU:22263 -Out of stock
Pioglitazone is an agonist of the peroxisome proliferator-activated receptor γ (PPARγ; EC50 = ~500-600 nM for both human and murine PPARγ).{10857,10670} It is selective for PPARγ over PPARα, exhibiting low level activation of PPARα at 1 µM and 5.4-fold activation at a concentration of 10 µM.{10857} Pioglitazone inhibits pyruvate oxidation and glucose production in hepatocytes when used at a concentration of 10 μM.{37440} In vivo, pioglitazone (0.3-3 mg/kg per day) reduces hyperglycemia, hyperlipidemia, and hyperinsulinemia in a dose-dependent manner in male Wistar fatty rats.{37441} It reduces the number of lesions in a transgenic rat adenocarcinoma of prostate (TRAP) model.{37442} Pioglitazone (2.5 mg/kg) also decreases production of neuroinflammatory cytokines and reduces immobility in the forced swim and tail suspension tests in a mouse model of chronic mild stress, indicating antidepressant-like activity that can be reversed by the PPARγ antagonist GW 9662 (Item No. 70785).{37443}
Brand:CaymanSKU:22263 -Out of stock
Pioglitazone is an agonist of the peroxisome proliferator-activated receptor γ (PPARγ; EC50 = ~500-600 nM for both human and murine PPARγ).{10857,10670} It is selective for PPARγ over PPARα, exhibiting low level activation of PPARα at 1 µM and 5.4-fold activation at a concentration of 10 µM.{10857} Pioglitazone inhibits pyruvate oxidation and glucose production in hepatocytes when used at a concentration of 10 μM.{37440} In vivo, pioglitazone (0.3-3 mg/kg per day) reduces hyperglycemia, hyperlipidemia, and hyperinsulinemia in a dose-dependent manner in male Wistar fatty rats.{37441} It reduces the number of lesions in a transgenic rat adenocarcinoma of prostate (TRAP) model.{37442} Pioglitazone (2.5 mg/kg) also decreases production of neuroinflammatory cytokines and reduces immobility in the forced swim and tail suspension tests in a mouse model of chronic mild stress, indicating antidepressant-like activity that can be reversed by the PPARγ antagonist GW 9662 (Item No. 70785).{37443}
Brand:CaymanSKU:22263 -Out of stock
Pioglitazone is an agonist of the peroxisome proliferator-activated receptor γ (PPARγ; EC50 = ~500-600 nM for both human and murine PPARγ).{10857,10670} It is selective for PPARγ over PPARα, exhibiting low level activation of PPARα at 1 µM and 5.4-fold activation at a concentration of 10 µM.{10857} Pioglitazone inhibits pyruvate oxidation and glucose production in hepatocytes when used at a concentration of 10 μM.{37440} In vivo, pioglitazone (0.3-3 mg/kg per day) reduces hyperglycemia, hyperlipidemia, and hyperinsulinemia in a dose-dependent manner in male Wistar fatty rats.{37441} It reduces the number of lesions in a transgenic rat adenocarcinoma of prostate (TRAP) model.{37442} Pioglitazone (2.5 mg/kg) also decreases production of neuroinflammatory cytokines and reduces immobility in the forced swim and tail suspension tests in a mouse model of chronic mild stress, indicating antidepressant-like activity that can be reversed by the PPARγ antagonist GW9662 (Item No. 70785).{37443}
Brand:CaymanSKU:10028 - 1 mgAvailable on backorder
Pioglitazone is an agonist of the peroxisome proliferator-activated receptor γ (PPARγ; EC50 = ~500-600 nM for both human and murine PPARγ).{10857,10670} It is selective for PPARγ over PPARα, exhibiting low level activation of PPARα at 1 µM and 5.4-fold activation at a concentration of 10 µM.{10857} Pioglitazone inhibits pyruvate oxidation and glucose production in hepatocytes when used at a concentration of 10 μM.{37440} In vivo, pioglitazone (0.3-3 mg/kg per day) reduces hyperglycemia, hyperlipidemia, and hyperinsulinemia in a dose-dependent manner in male Wistar fatty rats.{37441} It reduces the number of lesions in a transgenic rat adenocarcinoma of prostate (TRAP) model.{37442} Pioglitazone (2.5 mg/kg) also decreases production of neuroinflammatory cytokines and reduces immobility in the forced swim and tail suspension tests in a mouse model of chronic mild stress, indicating antidepressant-like activity that can be reversed by the PPARγ antagonist GW9662 (Item No. 70785).{37443}
Brand:CaymanSKU:10028 - 10 mgAvailable on backorder
Pioglitazone is an agonist of the peroxisome proliferator-activated receptor γ (PPARγ; EC50 = ~500-600 nM for both human and murine PPARγ).{10857,10670} It is selective for PPARγ over PPARα, exhibiting low level activation of PPARα at 1 µM and 5.4-fold activation at a concentration of 10 µM.{10857} Pioglitazone inhibits pyruvate oxidation and glucose production in hepatocytes when used at a concentration of 10 μM.{37440} In vivo, pioglitazone (0.3-3 mg/kg per day) reduces hyperglycemia, hyperlipidemia, and hyperinsulinemia in a dose-dependent manner in male Wistar fatty rats.{37441} It reduces the number of lesions in a transgenic rat adenocarcinoma of prostate (TRAP) model.{37442} Pioglitazone (2.5 mg/kg) also decreases production of neuroinflammatory cytokines and reduces immobility in the forced swim and tail suspension tests in a mouse model of chronic mild stress, indicating antidepressant-like activity that can be reversed by the PPARγ antagonist GW9662 (Item No. 70785).{37443}
Brand:CaymanSKU:10028 - 5 mgAvailable on backorder
Pioglitazone is an agonist of the peroxisome proliferator-activated receptor γ (PPARγ; EC50 = ~500-600 nM for both human and murine PPARγ).{10857,10670} It is selective for PPARγ over PPARα, exhibiting low level activation of PPARα at 1 µM and 5.4-fold activation at a concentration of 10 µM.{10857} Pioglitazone inhibits pyruvate oxidation and glucose production in hepatocytes when used at a concentration of 10 μM.{37440} In vivo, pioglitazone (0.3-3 mg/kg per day) reduces hyperglycemia, hyperlipidemia, and hyperinsulinemia in a dose-dependent manner in male Wistar fatty rats.{37441} It reduces the number of lesions in a transgenic rat adenocarcinoma of prostate (TRAP) model.{37442} Pioglitazone (2.5 mg/kg) also decreases production of neuroinflammatory cytokines and reduces immobility in the forced swim and tail suspension tests in a mouse model of chronic mild stress, indicating antidepressant-like activity that can be reversed by the PPARγ antagonist GW9662 (Item No. 70785).{37443}
Brand:CaymanSKU:10028 - 50 mgAvailable on backorder
Pioglitazone ketone is an active metabolite of the PPARγ agonist pioglitazone (Item Nos. 71745 | 10028 | 22263).{49141,49142,9838} Formation of pioglitazone ketone occurs primarly through cytochrome P450 (CYP) isoform CYP2C8-mediated metabolism of pioglitazone.{49141,49142} Pioglitazone ketone (100 mg/kg in the diet) reduces blood glucose levels in a KKAy mouse model of type 2 diabetes.{9838}
Brand:CaymanSKU:28044 - 5 mgAvailable on backorder
Pioglitazone-d4 is intended for use as an internal standard for the quantification of pioglitazone (Item Nos. 71745 | 10028 | 22263) by GC- or LC-MS. Pioglitazone is an agonist of the peroxisome proliferator-activated receptor γ (PPARγ; EC50 = ~500-600 nM for both human and murine PPARγ).{10857,10670} It is selective for PPARγ over PPARα, exhibiting low level activation of PPARα at 1 µM and 5.4-fold activation at a concentration of 10 µM.{10857} Pioglitazone inhibits pyruvate oxidation and glucose production in hepatocytes when used at a concentration of 10 μM.{37440} In vivo, pioglitazone (0.3-3 mg/kg per day) reduces hyperglycemia, hyperlipidemia, and hyperinsulinemia in a dose-dependent manner in male Wistar fatty rats.{37441} It reduces the number of lesions in a transgenic rat adenocarcinoma of prostate (TRAP) model.{37442} Pioglitazone (2.5 mg/kg) also decreases production of neuroinflammatory cytokines and reduces immobility in the forced swim and tail suspension tests in a mouse model of chronic mild stress, indicating antidepressant-like activity that can be reversed by the PPARγ antagonist GW 9662 (Item No. 70785).{37443}
Brand:CaymanSKU:-Available on backorder
Pioglitazone-d4 is intended for use as an internal standard for the quantification of pioglitazone (Item Nos. 71745 | 10028 | 22263) by GC- or LC-MS. Pioglitazone is an agonist of the peroxisome proliferator-activated receptor γ (PPARγ; EC50 = ~500-600 nM for both human and murine PPARγ).{10857,10670} It is selective for PPARγ over PPARα, exhibiting low level activation of PPARα at 1 µM and 5.4-fold activation at a concentration of 10 µM.{10857} Pioglitazone inhibits pyruvate oxidation and glucose production in hepatocytes when used at a concentration of 10 μM.{37440} In vivo, pioglitazone (0.3-3 mg/kg per day) reduces hyperglycemia, hyperlipidemia, and hyperinsulinemia in a dose-dependent manner in male Wistar fatty rats.{37441} It reduces the number of lesions in a transgenic rat adenocarcinoma of prostate (TRAP) model.{37442} Pioglitazone (2.5 mg/kg) also decreases production of neuroinflammatory cytokines and reduces immobility in the forced swim and tail suspension tests in a mouse model of chronic mild stress, indicating antidepressant-like activity that can be reversed by the PPARγ antagonist GW 9662 (Item No. 70785).{37443}
Brand:CaymanSKU:-Available on backorder
Pipacycline is a tetracycline antibiotic derivative.{47371} It inhibits the formation of penicillinase, the enzyme that inactivates penicillin in bacteria. It decreases oxygen uptake and inhibits growth of penicillin-resistant penicillinase-producing S. aureus.
Brand:CaymanSKU:27990 - 25 mgAvailable on backorder
Pipacycline is a tetracycline antibiotic derivative.{47371} It inhibits the formation of penicillinase, the enzyme that inactivates penicillin in bacteria. It decreases oxygen uptake and inhibits growth of penicillin-resistant penicillinase-producing S. aureus.
Brand:CaymanSKU:27990 - 5 mgAvailable on backorder
Pipequaline is a partial agonist of central benzodiazepine receptors (Ki = 78 nM in a radioligand binding assay).{35203} In mice, pipequaline enhances the effects of diazepam (Item No. ISO60177), further reducing foot shock-induced fighting behavior and the number of maximal electroshock-induced seizures and potentiating the muscle relaxant and hypnotic effects.{39426} Pipequaline also increases drinking in the Vogel punished drinking task indicating anxiolytic-like activity that can be reversed by the benzodiazepine receptor antagonist flumazenil (Item No. 14252).
Brand:CaymanSKU:23888 - 10 mgAvailable on backorder
Pipequaline is a partial agonist of central benzodiazepine receptors (Ki = 78 nM in a radioligand binding assay).{35203} In mice, pipequaline enhances the effects of diazepam (Item No. ISO60177), further reducing foot shock-induced fighting behavior and the number of maximal electroshock-induced seizures and potentiating the muscle relaxant and hypnotic effects.{39426} Pipequaline also increases drinking in the Vogel punished drinking task indicating anxiolytic-like activity that can be reversed by the benzodiazepine receptor antagonist flumazenil (Item No. 14252).
Brand:CaymanSKU:23888 - 100 mgAvailable on backorder
Pipequaline is a partial agonist of central benzodiazepine receptors (Ki = 78 nM in a radioligand binding assay).{35203} In mice, pipequaline enhances the effects of diazepam (Item No. ISO60177), further reducing foot shock-induced fighting behavior and the number of maximal electroshock-induced seizures and potentiating the muscle relaxant and hypnotic effects.{39426} Pipequaline also increases drinking in the Vogel punished drinking task indicating anxiolytic-like activity that can be reversed by the benzodiazepine receptor antagonist flumazenil (Item No. 14252).
Brand:CaymanSKU:23888 - 50 mgAvailable on backorder
Piperacillin is a broad-spectrum β-lactam antibiotic of the penicillin class.{27901,29941} It is active against Gram-negative and Gram-positive bacteria, including Enterococcus species, E. coli, and P. mirabilis (MIC50s = 0.5-2 µg/ml) as well as gentamicin-susceptible and -resistant strains of P. aeruginosa (MIC50s = 8 and 125 µg/ml, respectively).{29941} In a mouse model of systemic infection, piperacillin is active against P. aeruginosa 46220 when used alone or in combination with tazobactam (Item No. 25679; ED50s = 1.58 and 1.34 mg/animal, respectively).{37701} In the same model, it is less active against P. aeruginosa 46220 DR-2, which contains constitutively active β-lactamase, when used alone than when used in combination with tazobactam (ED50s = >20 and 4.39 mg/animal, respectively). Formulations containing piperacillin in combination with tazobactam have been used in the treatment of moderate-to-severe bacterial infections.
Brand:CaymanSKU:20766 -Available on backorder
Piperacillin is a broad-spectrum β-lactam antibiotic of the penicillin class.{27901,29941} It is active against Gram-negative and Gram-positive bacteria, including Enterococcus species, E. coli, and P. mirabilis (MIC50s = 0.5-2 µg/ml) as well as gentamicin-susceptible and -resistant strains of P. aeruginosa (MIC50s = 8 and 125 µg/ml, respectively).{29941} In a mouse model of systemic infection, piperacillin is active against P. aeruginosa 46220 when used alone or in combination with tazobactam (Item No. 25679; ED50s = 1.58 and 1.34 mg/animal, respectively).{37701} In the same model, it is less active against P. aeruginosa 46220 DR-2, which contains constitutively active β-lactamase, when used alone than when used in combination with tazobactam (ED50s = >20 and 4.39 mg/animal, respectively). Formulations containing piperacillin in combination with tazobactam have been used in the treatment of moderate-to-severe bacterial infections.
Brand:CaymanSKU:20766 -Available on backorder
Piperacillin is a broad-spectrum β-lactam antibiotic of the penicillin class.{27901,29941} It is active against Gram-negative and Gram-positive bacteria, including Enterococcus species, E. coli, and P. mirabilis (MIC50s = 0.5-2 µg/ml) as well as gentamicin-susceptible and -resistant strains of P. aeruginosa (MIC50s = 8 and 125 µg/ml, respectively).{29941} In a mouse model of systemic infection, piperacillin is active against P. aeruginosa 46220 when used alone or in combination with tazobactam (Item No. 25679; ED50s = 1.58 and 1.34 mg/animal, respectively).{37701} In the same model, it is less active against P. aeruginosa 46220 DR-2, which contains constitutively active β-lactamase, when used alone than when used in combination with tazobactam (ED50s = >20 and 4.39 mg/animal, respectively). Formulations containing piperacillin in combination with tazobactam have been used in the treatment of moderate-to-severe bacterial infections.
Brand:CaymanSKU:20766 -Available on backorder
Piperacillin is a broad-spectrum β-lactam antibiotic of the penicillin class.{27901,29941} It is active against Gram-negative and Gram-positive bacteria, including Enterococcus species, E. coli, and P. mirabilis (MIC50s = 0.5-2 µg/ml) as well as gentamicin-susceptible and -resistant strains of P. aeruginosa (MIC50s = 8 and 125 µg/ml, respectively).{29941} In a mouse model of systemic infection, piperacillin is active against P. aeruginosa 46220 when used alone or in combination with tazobactam (Item No. 25679; ED50s = 1.58 and 1.34 mg/animal, respectively).{37701} In the same model, it is less active against P. aeruginosa 46220 DR-2, which contains constitutively active β-lactamase, when used alone than when used in combination with tazobactam (ED50s = >20 and 4.39 mg/animal, respectively). Formulations containing piperacillin in combination with tazobactam have been used in the treatment of moderate-to-severe bacterial infections.
Brand:CaymanSKU:20766 -Available on backorder