Cayman
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Cyclooxygenase-2 (COX-2) appears to play a significant role in the development and progression of cancer and COX-2 inhibitors such as celecoxib exhibit anti-cancer activity.{11047} OSU03012 is an analog of celecoxib that exhibits anti-cancer activity in a COX-2-independent manner via inhibition of the phosphatidyl inositol-3-kinase/Akt pathway.{13637,13638,13639} It has an IC50 value of 5 µM for inhibition of 3-phosphoinositide-dependent kinase-1, and therefore Akt activation, with no measurable COX-2 inhibition up to 50 µM.{13638} OSU03012 is a potent inhibitor of tumor cell growth with an average inhibitory concentration of 1.1 µM across a panel of 60 cancer cell lines.{13638} It does not inhibit signal transduction through the mitogen-activated protein kinase (MAPK) pathway.{13639} OSU03012 induces apoptosis of chronic lymphocytic leukemia cells independent of bcl-2 overexpression using both caspase-dependent and independent pathways.{13637}
Brand:CaymanSKU:10008005 - 100 mgAvailable on backorder
Cyclooxygenase-2 (COX-2) appears to play a significant role in the development and progression of cancer and COX-2 inhibitors such as celecoxib exhibit anti-cancer activity.{11047} OSU03012 is an analog of celecoxib that exhibits anti-cancer activity in a COX-2-independent manner via inhibition of the phosphatidyl inositol-3-kinase/Akt pathway.{13637,13638,13639} It has an IC50 value of 5 µM for inhibition of 3-phosphoinositide-dependent kinase-1, and therefore Akt activation, with no measurable COX-2 inhibition up to 50 µM.{13638} OSU03012 is a potent inhibitor of tumor cell growth with an average inhibitory concentration of 1.1 µM across a panel of 60 cancer cell lines.{13638} It does not inhibit signal transduction through the mitogen-activated protein kinase (MAPK) pathway.{13639} OSU03012 induces apoptosis of chronic lymphocytic leukemia cells independent of bcl-2 overexpression using both caspase-dependent and independent pathways.{13637}
Brand:CaymanSKU:10008005 - 5 mgAvailable on backorder
Cyclooxygenase-2 (COX-2) appears to play a significant role in the development and progression of cancer and COX-2 inhibitors such as celecoxib exhibit anti-cancer activity.{11047} OSU03012 is an analog of celecoxib that exhibits anti-cancer activity in a COX-2-independent manner via inhibition of the phosphatidyl inositol-3-kinase/Akt pathway.{13637,13638,13639} It has an IC50 value of 5 µM for inhibition of 3-phosphoinositide-dependent kinase-1, and therefore Akt activation, with no measurable COX-2 inhibition up to 50 µM.{13638} OSU03012 is a potent inhibitor of tumor cell growth with an average inhibitory concentration of 1.1 µM across a panel of 60 cancer cell lines.{13638} It does not inhibit signal transduction through the mitogen-activated protein kinase (MAPK) pathway.{13639} OSU03012 induces apoptosis of chronic lymphocytic leukemia cells independent of bcl-2 overexpression using both caspase-dependent and independent pathways.{13637}
Brand:CaymanSKU:10008005 - 50 mgAvailable on backorder
OSW-1 is a saponin that has been found in O. saundersiae and has antiviral and anticancer activities.{53441} It is an inhibitor of oxysterol-binding protein (OSBP) and its paralog OSBP-related protein 4 (ORP4) with Ki values of 16 and 71 nM, respectively, in radioligand binding assays using HEK293T cell lysates.{53442} It induces OSBP translocalization from the cytoplasm to the trans-Golgi network and decreases intracellular levels of OSBP in HEK293 cells.{53442,45822} OSW-1 inhibits replication of a variety of enteroviruses (IC50s = 2.4-9.4 nM), including replication of coxsackievirus B3 (CVB3) in infected HeLa R19 cells in an OSBP-dependent manner when used at a concentration of 3 nM.{53443} It also inhibits replication of hepatitis C virus (HCV) but not mouse hepatitis virus (MHV), a coronavirus.{45895} It protects against CVA9 and echovirus 2 infection in HeLa cells when used at a concentration of 10 nM.{53443} OSW-1 inhibits growth of HeLa and HEK293 cells (GI50s = 0.33 and 0.22 nM, respectively).{53442}
Brand:CaymanSKU:30310 - 1 mgAvailable on backorder
OSW-1 is a saponin that has been found in O. saundersiae and has antiviral and anticancer activities.{53441} It is an inhibitor of oxysterol-binding protein (OSBP) and its paralog OSBP-related protein 4 (ORP4) with Ki values of 16 and 71 nM, respectively, in radioligand binding assays using HEK293T cell lysates.{53442} It induces OSBP translocalization from the cytoplasm to the trans-Golgi network and decreases intracellular levels of OSBP in HEK293 cells.{53442,45822} OSW-1 inhibits replication of a variety of enteroviruses (IC50s = 2.4-9.4 nM), including replication of coxsackievirus B3 (CVB3) in infected HeLa R19 cells in an OSBP-dependent manner when used at a concentration of 3 nM.{53443} It also inhibits replication of hepatitis C virus (HCV) but not mouse hepatitis virus (MHV), a coronavirus.{45895} It protects against CVA9 and echovirus 2 infection in HeLa cells when used at a concentration of 10 nM.{53443} OSW-1 inhibits growth of HeLa and HEK293 cells (GI50s = 0.33 and 0.22 nM, respectively).{53442}
Brand:CaymanSKU:30310 - 5 mgAvailable on backorder
OSW-1 is a saponin that has been found in O. saundersiae and has antiviral and anticancer activities.{53441} It is an inhibitor of oxysterol-binding protein (OSBP) and its paralog OSBP-related protein 4 (ORP4) with Ki values of 16 and 71 nM, respectively, in radioligand binding assays using HEK293T cell lysates.{53442} It induces OSBP translocalization from the cytoplasm to the trans-Golgi network and decreases intracellular levels of OSBP in HEK293 cells.{53442,45822} OSW-1 inhibits replication of a variety of enteroviruses (IC50s = 2.4-9.4 nM), including replication of coxsackievirus B3 (CVB3) in infected HeLa R19 cells in an OSBP-dependent manner when used at a concentration of 3 nM.{53443} It also inhibits replication of hepatitis C virus (HCV) but not mouse hepatitis virus (MHV), a coronavirus.{45895} It protects against CVA9 and echovirus 2 infection in HeLa cells when used at a concentration of 10 nM.{53443} OSW-1 inhibits growth of HeLa and HEK293 cells (GI50s = 0.33 and 0.22 nM, respectively).{53442}
Brand:CaymanSKU:30310 - 500 µgAvailable on backorder
Otilonium is an inhibitor of L-type (IC50 = 2.3 µM) and T-type calcium channels (IC50s = 0.8, 1.1, and 0.4 µM for Cav3.1, Cav3.2, and Cav3.3, respectively).{46774,46775} It is also an antagonist of muscarinic acetylcholine receptors (mAChRs; IC50s = 0.054, 0.4, 0.222, and 0.156 µM for M1, M2, M4, and M5 muscarinic receptors, respectively) and the platelet activating factor (PAF) receptor (IC50 = 0.0552 µM).{46778} Otilonium inhibits the inward calcium current in isolated rat colonic smooth muscle cells (EC50 = 885 nM), an effect that can be blocked by the L-type calcium channel inhibitor nifedipine (Item No. 11106).{46774} It inhibits contractions induced by the muscarinic acetylcholine receptor (mAChR) agonist methacholine in isolated circular muscle of the guinea pig proximal colon (IC50 = 3.7 µM).{46776} Otilonium (4 mg/kg) decreases fecal excretion and wet dog shakes and increases the tail withdrawal latency in the tail-flick test in a rat model of opioid withdrawal syndrome induced by morphine and naloxone.{46777}
Brand:CaymanSKU:29907 - 10 mgAvailable on backorder
Otilonium is an inhibitor of L-type (IC50 = 2.3 µM) and T-type calcium channels (IC50s = 0.8, 1.1, and 0.4 µM for Cav3.1, Cav3.2, and Cav3.3, respectively).{46774,46775} It is also an antagonist of muscarinic acetylcholine receptors (mAChRs; IC50s = 0.054, 0.4, 0.222, and 0.156 µM for M1, M2, M4, and M5 muscarinic receptors, respectively) and the platelet activating factor (PAF) receptor (IC50 = 0.0552 µM).{46778} Otilonium inhibits the inward calcium current in isolated rat colonic smooth muscle cells (EC50 = 885 nM), an effect that can be blocked by the L-type calcium channel inhibitor nifedipine (Item No. 11106).{46774} It inhibits contractions induced by the muscarinic acetylcholine receptor (mAChR) agonist methacholine in isolated circular muscle of the guinea pig proximal colon (IC50 = 3.7 µM).{46776} Otilonium (4 mg/kg) decreases fecal excretion and wet dog shakes and increases the tail withdrawal latency in the tail-flick test in a rat model of opioid withdrawal syndrome induced by morphine and naloxone.{46777}
Brand:CaymanSKU:29907 - 100 mgAvailable on backorder
Otilonium is an inhibitor of L-type (IC50 = 2.3 µM) and T-type calcium channels (IC50s = 0.8, 1.1, and 0.4 µM for Cav3.1, Cav3.2, and Cav3.3, respectively).{46774,46775} It is also an antagonist of muscarinic acetylcholine receptors (mAChRs; IC50s = 0.054, 0.4, 0.222, and 0.156 µM for M1, M2, M4, and M5 muscarinic receptors, respectively) and the platelet activating factor (PAF) receptor (IC50 = 0.0552 µM).{46778} Otilonium inhibits the inward calcium current in isolated rat colonic smooth muscle cells (EC50 = 885 nM), an effect that can be blocked by the L-type calcium channel inhibitor nifedipine (Item No. 11106).{46774} It inhibits contractions induced by the muscarinic acetylcholine receptor (mAChR) agonist methacholine in isolated circular muscle of the guinea pig proximal colon (IC50 = 3.7 µM).{46776} Otilonium (4 mg/kg) decreases fecal excretion and wet dog shakes and increases the tail withdrawal latency in the tail-flick test in a rat model of opioid withdrawal syndrome induced by morphine and naloxone.{46777}
Brand:CaymanSKU:29907 - 250 mgAvailable on backorder
Otilonium is an inhibitor of L-type (IC50 = 2.3 µM) and T-type calcium channels (IC50s = 0.8, 1.1, and 0.4 µM for Cav3.1, Cav3.2, and Cav3.3, respectively).{46774,46775} It is also an antagonist of muscarinic acetylcholine receptors (mAChRs; IC50s = 0.054, 0.4, 0.222, and 0.156 µM for M1, M2, M4, and M5 muscarinic receptors, respectively) and the platelet activating factor (PAF) receptor (IC50 = 0.0552 µM).{46778} Otilonium inhibits the inward calcium current in isolated rat colonic smooth muscle cells (EC50 = 885 nM), an effect that can be blocked by the L-type calcium channel inhibitor nifedipine (Item No. 11106).{46774} It inhibits contractions induced by the muscarinic acetylcholine receptor (mAChR) agonist methacholine in isolated circular muscle of the guinea pig proximal colon (IC50 = 3.7 µM).{46776} Otilonium (4 mg/kg) decreases fecal excretion and wet dog shakes and increases the tail withdrawal latency in the tail-flick test in a rat model of opioid withdrawal syndrome induced by morphine and naloxone.{46777}
Brand:CaymanSKU:29907 - 50 mgAvailable on backorder
OTS514 is an inhibitor of lymphokine-activated killer T cell-originated protein kinase (TOPK; IC50 = 2.6 nM), a serine-threonine kinase often overexpressed and transactivated in several types of cancer.{32494,37578} OTS514 (10 nM) selectively inhibits growth of patient-derived acute myeloid leukemia (AML) cells over normal CD34+ cells. It shows similar growth inhibitory effects in multiple small cell lung, kidney, and ovarian cancer cell lines (IC50s = 0.4-42.6 nM).{37579,37580,32493} In vivo, OTS514 (25 and 50 mg/kg) increases survival in a peritoneal mouse dissemination model of ovarian cancer. It also dose-dependently inhibits tumor growth in an A549 mouse xenograft model when administered at doses of 1, 2.5, and 5 mg/kg.{32494}
Brand:CaymanSKU:-Out of stock
OTS514 is an inhibitor of lymphokine-activated killer T cell-originated protein kinase (TOPK; IC50 = 2.6 nM), a serine-threonine kinase often overexpressed and transactivated in several types of cancer.{32494,37578} OTS514 (10 nM) selectively inhibits growth of patient-derived acute myeloid leukemia (AML) cells over normal CD34+ cells. It shows similar growth inhibitory effects in multiple small cell lung, kidney, and ovarian cancer cell lines (IC50s = 0.4-42.6 nM).{37579,37580,32493} In vivo, OTS514 (25 and 50 mg/kg) increases survival in a peritoneal mouse dissemination model of ovarian cancer. It also dose-dependently inhibits tumor growth in an A549 mouse xenograft model when administered at doses of 1, 2.5, and 5 mg/kg.{32494}
Brand:CaymanSKU:-Out of stock
OTS514 is an inhibitor of lymphokine-activated killer T cell-originated protein kinase (TOPK; IC50 = 2.6 nM), a serine-threonine kinase often overexpressed and transactivated in several types of cancer.{32494,37578} OTS514 (10 nM) selectively inhibits growth of patient-derived acute myeloid leukemia (AML) cells over normal CD34+ cells. It shows similar growth inhibitory effects in multiple small cell lung, kidney, and ovarian cancer cell lines (IC50s = 0.4-42.6 nM).{37579,37580,32493} In vivo, OTS514 (25 and 50 mg/kg) increases survival in a peritoneal mouse dissemination model of ovarian cancer. It also dose-dependently inhibits tumor growth in an A549 mouse xenograft model when administered at doses of 1, 2.5, and 5 mg/kg.{32494}
Brand:CaymanSKU:-Out of stock
OTS964 is an inhibitor of lymphokine-activated killer T cell-originated protein kinase (TOPK; IC50 = 28 nM).{32494} It specifically blocks cytokinesis, leading to apoptosis, in a broad range of cancer cells.{32494,32493} OTS964 induces apoptosis of human lung cancer cells in mouse xenografts.{32494}
Brand:CaymanSKU:-Out of stock
OTS964 is an inhibitor of lymphokine-activated killer T cell-originated protein kinase (TOPK; IC50 = 28 nM).{32494} It specifically blocks cytokinesis, leading to apoptosis, in a broad range of cancer cells.{32494,32493} OTS964 induces apoptosis of human lung cancer cells in mouse xenografts.{32494}
Brand:CaymanSKU:-Out of stock
OTS964 is an inhibitor of lymphokine-activated killer T cell-originated protein kinase (TOPK; IC50 = 28 nM).{32494} It specifically blocks cytokinesis, leading to apoptosis, in a broad range of cancer cells.{32494,32493} OTS964 induces apoptosis of human lung cancer cells in mouse xenografts.{32494}
Brand:CaymanSKU:-Out of stock
Maternal embryonic leucine zipper kinase (MELK) is a serine/threonine kinase that regulates signaling central to cell cycling, stem cell renewal, apoptosis, and other cellular processes.{27684} MELK is overexpressed in some forms of cancer, particularly those with aggressive undifferentiated tumors.{27683,24926,24930} OTSSP167 is a potent inhibitor of MELK (IC50 = 0.41 nM).{27685} It suppresses the growth of diverse cancer cell lines at low nanomolar concentrations.{27685} It also blocks the phosphorylation of MELK-specific substrates and reduces the ability of MCF-7 breast cancer cells to invade and form spheroids in Matrigel.{27685} OTSSP167 is also effective in vivo when delivered either orally or intravenously, suppressing the growth of xenograft tumors in mice.{27685,27686}
Brand:CaymanSKU:-Out of stock
Maternal embryonic leucine zipper kinase (MELK) is a serine/threonine kinase that regulates signaling central to cell cycling, stem cell renewal, apoptosis, and other cellular processes.{27684} MELK is overexpressed in some forms of cancer, particularly those with aggressive undifferentiated tumors.{27683,24926,24930} OTSSP167 is a potent inhibitor of MELK (IC50 = 0.41 nM).{27685} It suppresses the growth of diverse cancer cell lines at low nanomolar concentrations.{27685} It also blocks the phosphorylation of MELK-specific substrates and reduces the ability of MCF-7 breast cancer cells to invade and form spheroids in Matrigel.{27685} OTSSP167 is also effective in vivo when delivered either orally or intravenously, suppressing the growth of xenograft tumors in mice.{27685,27686}
Brand:CaymanSKU:-Out of stock
Maternal embryonic leucine zipper kinase (MELK) is a serine/threonine kinase that regulates signaling central to cell cycling, stem cell renewal, apoptosis, and other cellular processes.{27684} MELK is overexpressed in some forms of cancer, particularly those with aggressive undifferentiated tumors.{27683,24926,24930} OTSSP167 is a potent inhibitor of MELK (IC50 = 0.41 nM).{27685} It suppresses the growth of diverse cancer cell lines at low nanomolar concentrations.{27685} It also blocks the phosphorylation of MELK-specific substrates and reduces the ability of MCF-7 breast cancer cells to invade and form spheroids in Matrigel.{27685} OTSSP167 is also effective in vivo when delivered either orally or intravenously, suppressing the growth of xenograft tumors in mice.{27685,27686}
Brand:CaymanSKU:-Out of stock
OTX008 is a small molecule topomimetic of the antiangiogenic peptide anginex and an inhibitor of galectin-1 (Gal-1).{41594} It decreases lactose binding to Gal-1 with Kd values of 290 and 100 μM in the presence and absence of OTX008, respectively, and is cytotoxic against a cancer cell panel with IC50 values that directly correlate to Gal-1 mRNA expression. OTX008 inhibits proliferation of human umbilical vein endothelial cells (HUVECs; IC50 = 2 μM) and reduces HUVEC migration in a wound healing assay.{41595} OTX008 is angiostatic in a chorioallantoic membrane (CAM) assay, inducing formation of shorter, finer, and less defined vessels than vehicle control in fertilized chicken eggs. In vivo, OTX008 (2.4 and 10 mg/kg) reduces tumor growth in the MA148 ovarian mouse xenograft model and the B16 murine melanoma syngeneic model via decreases in tumor microvessel density and induction of apoptosis.
Brand:CaymanSKU:23130 - 1 mgAvailable on backorder
OTX008 is a small molecule topomimetic of the antiangiogenic peptide anginex and an inhibitor of galectin-1 (Gal-1).{41594} It decreases lactose binding to Gal-1 with Kd values of 290 and 100 μM in the presence and absence of OTX008, respectively, and is cytotoxic against a cancer cell panel with IC50 values that directly correlate to Gal-1 mRNA expression. OTX008 inhibits proliferation of human umbilical vein endothelial cells (HUVECs; IC50 = 2 μM) and reduces HUVEC migration in a wound healing assay.{41595} OTX008 is angiostatic in a chorioallantoic membrane (CAM) assay, inducing formation of shorter, finer, and less defined vessels than vehicle control in fertilized chicken eggs. In vivo, OTX008 (2.4 and 10 mg/kg) reduces tumor growth in the MA148 ovarian mouse xenograft model and the B16 murine melanoma syngeneic model via decreases in tumor microvessel density and induction of apoptosis.
Brand:CaymanSKU:23130 - 10 mgAvailable on backorder
OTX008 is a small molecule topomimetic of the antiangiogenic peptide anginex and an inhibitor of galectin-1 (Gal-1).{41594} It decreases lactose binding to Gal-1 with Kd values of 290 and 100 μM in the presence and absence of OTX008, respectively, and is cytotoxic against a cancer cell panel with IC50 values that directly correlate to Gal-1 mRNA expression. OTX008 inhibits proliferation of human umbilical vein endothelial cells (HUVECs; IC50 = 2 μM) and reduces HUVEC migration in a wound healing assay.{41595} OTX008 is angiostatic in a chorioallantoic membrane (CAM) assay, inducing formation of shorter, finer, and less defined vessels than vehicle control in fertilized chicken eggs. In vivo, OTX008 (2.4 and 10 mg/kg) reduces tumor growth in the MA148 ovarian mouse xenograft model and the B16 murine melanoma syngeneic model via decreases in tumor microvessel density and induction of apoptosis.
Brand:CaymanSKU:23130 - 5 mgAvailable on backorder
OTX008 is a small molecule topomimetic of the antiangiogenic peptide anginex and an inhibitor of galectin-1 (Gal-1).{41594} It decreases lactose binding to Gal-1 with Kd values of 290 and 100 μM in the presence and absence of OTX008, respectively, and is cytotoxic against a cancer cell panel with IC50 values that directly correlate to Gal-1 mRNA expression. OTX008 inhibits proliferation of human umbilical vein endothelial cells (HUVECs; IC50 = 2 μM) and reduces HUVEC migration in a wound healing assay.{41595} OTX008 is angiostatic in a chorioallantoic membrane (CAM) assay, inducing formation of shorter, finer, and less defined vessels than vehicle control in fertilized chicken eggs. In vivo, OTX008 (2.4 and 10 mg/kg) reduces tumor growth in the MA148 ovarian mouse xenograft model and the B16 murine melanoma syngeneic model via decreases in tumor microvessel density and induction of apoptosis.
Brand:CaymanSKU:23130 - 500 µgAvailable on backorder
The bromodomain and extra terminal domain (BET) family of proteins, including BRD2, BRD3, and BRD4, play a key role in many cellular processes, including inflammatory gene expression, mitosis, and viral/host interaction by controlling the assembly of histone acetylation-dependent chromatin complexes. OTX015 is an orally bioavailable, small molecule inhibitor of BRD2, BRD3, and BRD4 (EC50s = 10-19 nM).{25844} It displays antiproliferative effects at a sub-micromolar range in vitro in a wide range of solid tumor types and leukemias, downregulating c-Myc expression and inducing cell cycle arrest and apoptosis.{25844,25845,25843} At 100 mg/kg, OTX015 has been shown to inhibit the growth of Ty82 BRD-NUT midline carcinoma tumors in nude mice by 79%.{25844}
Brand:CaymanSKU:- The bromodomain and extra terminal domain (BET) family of proteins, including BRD2, BRD3, and BRD4, play a key role in many cellular processes, including inflammatory gene expression, mitosis, and viral/host interaction by controlling the assembly of histone acetylation-dependent chromatin complexes. OTX015 is an orally bioavailable, small molecule inhibitor of BRD2, BRD3, and BRD4 (EC50s = 10-19 nM).{25844} It displays antiproliferative effects at a sub-micromolar range in vitro in a wide range of solid tumor types and leukemias, downregulating c-Myc expression and inducing cell cycle arrest and apoptosis.{25844,25845,25843} At 100 mg/kg, OTX015 has been shown to inhibit the growth of Ty82 BRD-NUT midline carcinoma tumors in nude mice by 79%.{25844}
Brand:CaymanSKU:- The bromodomain and extra terminal domain (BET) family of proteins, including BRD2, BRD3, and BRD4, play a key role in many cellular processes, including inflammatory gene expression, mitosis, and viral/host interaction by controlling the assembly of histone acetylation-dependent chromatin complexes. OTX015 is an orally bioavailable, small molecule inhibitor of BRD2, BRD3, and BRD4 (EC50s = 10-19 nM).{25844} It displays antiproliferative effects at a sub-micromolar range in vitro in a wide range of solid tumor types and leukemias, downregulating c-Myc expression and inducing cell cycle arrest and apoptosis.{25844,25845,25843} At 100 mg/kg, OTX015 has been shown to inhibit the growth of Ty82 BRD-NUT midline carcinoma tumors in nude mice by 79%.{25844}
Brand:CaymanSKU:-
γ-Glutamyl transferase (GGT) is involved in the transfer of amino acids across the plasma membrane as well as in glutathione metabolism.{18312} Serum GGT activity is commonly used as a marker of liver dysfunction and alcohol abuse. It is also useful as a biomarker of type 2 diabetes and cardiovascular disease.{18312} OU749 is a non-competitive inhibitor of GGT, exhibiting a Ki value of 17.6 μM.{18311} It is 150-fold less toxic than the GGT inhibitor acivicin toward dividing cells. OU749 inhibits human GGT 7- to 10-fold more potently than rat or murine GGT and does not inhibit porcine GGT.{18311}
Brand:CaymanSKU:- γ-Glutamyl transferase (GGT) is involved in the transfer of amino acids across the plasma membrane as well as in glutathione metabolism.{18312} Serum GGT activity is commonly used as a marker of liver dysfunction and alcohol abuse. It is also useful as a biomarker of type 2 diabetes and cardiovascular disease.{18312} OU749 is a non-competitive inhibitor of GGT, exhibiting a Ki value of 17.6 μM.{18311} It is 150-fold less toxic than the GGT inhibitor acivicin toward dividing cells. OU749 inhibits human GGT 7- to 10-fold more potently than rat or murine GGT and does not inhibit porcine GGT.{18311}
Brand:CaymanSKU:- γ-Glutamyl transferase (GGT) is involved in the transfer of amino acids across the plasma membrane as well as in glutathione metabolism.{18312} Serum GGT activity is commonly used as a marker of liver dysfunction and alcohol abuse. It is also useful as a biomarker of type 2 diabetes and cardiovascular disease.{18312} OU749 is a non-competitive inhibitor of GGT, exhibiting a Ki value of 17.6 μM.{18311} It is 150-fold less toxic than the GGT inhibitor acivicin toward dividing cells. OU749 inhibits human GGT 7- to 10-fold more potently than rat or murine GGT and does not inhibit porcine GGT.{18311}
Brand:CaymanSKU:- γ-Glutamyl transferase (GGT) is involved in the transfer of amino acids across the plasma membrane as well as in glutathione metabolism.{18312} Serum GGT activity is commonly used as a marker of liver dysfunction and alcohol abuse. It is also useful as a biomarker of type 2 diabetes and cardiovascular disease.{18312} OU749 is a non-competitive inhibitor of GGT, exhibiting a Ki value of 17.6 μM.{18311} It is 150-fold less toxic than the GGT inhibitor acivicin toward dividing cells. OU749 inhibits human GGT 7- to 10-fold more potently than rat or murine GGT and does not inhibit porcine GGT.{18311}
Brand:CaymanSKU:-
OUL35 is an inhibitor of poly(ADP-ribose) polymerase 10 (PARP10; IC50 = 329 nM).{45541} It is selective for PARP10 over a panel of 15 PARP enzymes, including PARP4, PARP14, and PARP16 (IC50s = 22.6, 23.4, and 4.17 μM, respectively). OUL35 (10 μM) reverses inhibition of HeLa cell proliferation induced by PARP10 overexpression. It sensitizes HeLa cells to hydroxyurea (Item No. 23725), increasing hydroxyurea-induced inhibition of cell proliferation when used at a concentration of 5 μM.
Brand:CaymanSKU:28845 - 10 mgAvailable on backorder
OUL35 is an inhibitor of poly(ADP-ribose) polymerase 10 (PARP10; IC50 = 329 nM).{45541} It is selective for PARP10 over a panel of 15 PARP enzymes, including PARP4, PARP14, and PARP16 (IC50s = 22.6, 23.4, and 4.17 μM, respectively). OUL35 (10 μM) reverses inhibition of HeLa cell proliferation induced by PARP10 overexpression. It sensitizes HeLa cells to hydroxyurea (Item No. 23725), increasing hydroxyurea-induced inhibition of cell proliferation when used at a concentration of 5 μM.
Brand:CaymanSKU:28845 - 25 mgAvailable on backorder
OUL35 is an inhibitor of poly(ADP-ribose) polymerase 10 (PARP10; IC50 = 329 nM).{45541} It is selective for PARP10 over a panel of 15 PARP enzymes, including PARP4, PARP14, and PARP16 (IC50s = 22.6, 23.4, and 4.17 μM, respectively). OUL35 (10 μM) reverses inhibition of HeLa cell proliferation induced by PARP10 overexpression. It sensitizes HeLa cells to hydroxyurea (Item No. 23725), increasing hydroxyurea-induced inhibition of cell proliferation when used at a concentration of 5 μM.
Brand:CaymanSKU:28845 - 5 mgAvailable on backorder
OXA-01 is an inhibitor of both mTORC1 and mTORC2 (IC50s = 11 and 29 nM, respectively).{29741} It is selective for mTOR over PI3K isoforms and DNA protein kinase.{29741} OXA-01 reduces VEGF production in tumors in association with decreased vessel sprouting.{29741}
Brand:CaymanSKU:20456 -Available on backorder
OXA-01 is an inhibitor of both mTORC1 and mTORC2 (IC50s = 11 and 29 nM, respectively).{29741} It is selective for mTOR over PI3K isoforms and DNA protein kinase.{29741} OXA-01 reduces VEGF production in tumors in association with decreased vessel sprouting.{29741}
Brand:CaymanSKU:20456 -Available on backorder
OXA-01 is an inhibitor of both mTORC1 and mTORC2 (IC50s = 11 and 29 nM, respectively).{29741} It is selective for mTOR over PI3K isoforms and DNA protein kinase.{29741} OXA-01 reduces VEGF production in tumors in association with decreased vessel sprouting.{29741}
Brand:CaymanSKU:20456 -Available on backorder
OXA-01 is an inhibitor of both mTORC1 and mTORC2 (IC50s = 11 and 29 nM, respectively).{29741} It is selective for mTOR over PI3K isoforms and DNA protein kinase.{29741} OXA-01 reduces VEGF production in tumors in association with decreased vessel sprouting.{29741}
Brand:CaymanSKU:20456 -Available on backorder
Oxacillin is a semisynthetic β-lactam antibiotic.{32140,39735} It is active against clinical isolates of methicillin-susceptible S. aureus and penicillin-susceptible S. pneumoniae, as well as group A, group B, and viridans group streptococci with MIC90 values ranging from 0.06 to 2 µg/ml in vitro.{22658} Oxacillin is less effective toward other bacteria with MIC90 values of greater than 16 µg/ml for S. epidermidis, S. haemolyticus, E. faecalis, E. faecium, methicillin-resistant S. aureus (MRSA), and penicillin-intermediate and -resistant S. pneumoniae. It targets the bacterial cell wall, inhibiting S. pneumoniae penicillin-binding proteins 1a, 1b, 2a, 2b, and 3 in vitro with IC50 values ranging from 0.17 to 1.75 µM.{21711,39735} Oxacillin inhibits growth of S. aureus in a thigh model of infection in mice (ED50 = 45.19 mg/kg, s.c.).{39736} Formulations containing oxacillin have been used in the treatment of susceptible bacterial infections.
Brand:CaymanSKU:23954 - 1 gAvailable on backorder
Oxacillin is a semisynthetic β-lactam antibiotic.{32140,39735} It is active against clinical isolates of methicillin-susceptible S. aureus and penicillin-susceptible S. pneumoniae, as well as group A, group B, and viridans group streptococci with MIC90 values ranging from 0.06 to 2 µg/ml in vitro.{22658} Oxacillin is less effective toward other bacteria with MIC90 values of greater than 16 µg/ml for S. epidermidis, S. haemolyticus, E. faecalis, E. faecium, methicillin-resistant S. aureus (MRSA), and penicillin-intermediate and -resistant S. pneumoniae. It targets the bacterial cell wall, inhibiting S. pneumoniae penicillin-binding proteins 1a, 1b, 2a, 2b, and 3 in vitro with IC50 values ranging from 0.17 to 1.75 µM.{21711,39735} Oxacillin inhibits growth of S. aureus in a thigh model of infection in mice (ED50 = 45.19 mg/kg, s.c.).{39736} Formulations containing oxacillin have been used in the treatment of susceptible bacterial infections.
Brand:CaymanSKU:23954 - 10 gAvailable on backorder
Oxacillin is a semisynthetic β-lactam antibiotic.{32140,39735} It is active against clinical isolates of methicillin-susceptible S. aureus and penicillin-susceptible S. pneumoniae, as well as group A, group B, and viridans group streptococci with MIC90 values ranging from 0.06 to 2 µg/ml in vitro.{22658} Oxacillin is less effective toward other bacteria with MIC90 values of greater than 16 µg/ml for S. epidermidis, S. haemolyticus, E. faecalis, E. faecium, methicillin-resistant S. aureus (MRSA), and penicillin-intermediate and -resistant S. pneumoniae. It targets the bacterial cell wall, inhibiting S. pneumoniae penicillin-binding proteins 1a, 1b, 2a, 2b, and 3 in vitro with IC50 values ranging from 0.17 to 1.75 µM.{21711,39735} Oxacillin inhibits growth of S. aureus in a thigh model of infection in mice (ED50 = 45.19 mg/kg, s.c.).{39736} Formulations containing oxacillin have been used in the treatment of susceptible bacterial infections.
Brand:CaymanSKU:23954 - 5 gAvailable on backorder
Brand:CaymanSKU:29574 - 1 mgAvailable on backorder
Oxaliplatin is a platinum-based antineoplastic agent that functions by forming DNA adducts specifically in cancer cells, preventing DNA replication and transcription which leads to cell death.{21805,21804} Oxaliplatin has cytotoxic effects in a broad range of cell lines, including colon, ovarian, and lung cancer, with IC50 values ranging from 0.5-240, 0.12-19.8, and 2.6-6.1 μM, respectively.{21804} Through its general cytotoxic effects, oxaliplatin has anti-tumor activity against advanced colorectal cancer and is typically administered with fluorouracil and leucovorin in a combination known as FOLFOX.{21805,21806}
Brand:CaymanSKU:- Oxaliplatin is a platinum-based antineoplastic agent that functions by forming DNA adducts specifically in cancer cells, preventing DNA replication and transcription which leads to cell death.{21805,21804} Oxaliplatin has cytotoxic effects in a broad range of cell lines, including colon, ovarian, and lung cancer, with IC50 values ranging from 0.5-240, 0.12-19.8, and 2.6-6.1 μM, respectively.{21804} Through its general cytotoxic effects, oxaliplatin has anti-tumor activity against advanced colorectal cancer and is typically administered with fluorouracil and leucovorin in a combination known as FOLFOX.{21805,21806}
Brand:CaymanSKU:- Oxaliplatin is a platinum-based antineoplastic agent that functions by forming DNA adducts specifically in cancer cells, preventing DNA replication and transcription which leads to cell death.{21805,21804} Oxaliplatin has cytotoxic effects in a broad range of cell lines, including colon, ovarian, and lung cancer, with IC50 values ranging from 0.5-240, 0.12-19.8, and 2.6-6.1 μM, respectively.{21804} Through its general cytotoxic effects, oxaliplatin has anti-tumor activity against advanced colorectal cancer and is typically administered with fluorouracil and leucovorin in a combination known as FOLFOX.{21805,21806}
Brand:CaymanSKU:-
Oxaloacetic acid is an α-keto acid and a key component of cellular metabolism in its conjugate base form, oxaloacetate.{57040,57041,57042} Oxaloacetate reacts with acetyl-coenzyme A (acetyl-CoA; Item No. 16160) and water to form citrate in the first step of the citric acid cycle and is regenerated by oxidation of L-malate in the final step.{57041} It is an intermediate in gluconeogenesis that is formed in mitochondria via carboxylation of pyruvate and subsequently decarboxylated and phosphorylated to form phosphoenolpyruvate.{57042} It can be converted to aspartate via addition of an amino group from glutamate.{57040} Oxaloacetate (30 μmol/min per 100 g for 30 minutes, i.v.) reduces blood glutamate levels, severity of neurological dysfunction, and brain edema in a rat model of closed head injury.{57043}
Brand:CaymanSKU:30280 - 1 gAvailable on backorder
Oxaloacetic acid is an α-keto acid and a key component of cellular metabolism in its conjugate base form, oxaloacetate.{57040,57041,57042} Oxaloacetate reacts with acetyl-coenzyme A (acetyl-CoA; Item No. 16160) and water to form citrate in the first step of the citric acid cycle and is regenerated by oxidation of L-malate in the final step.{57041} It is an intermediate in gluconeogenesis that is formed in mitochondria via carboxylation of pyruvate and subsequently decarboxylated and phosphorylated to form phosphoenolpyruvate.{57042} It can be converted to aspartate via addition of an amino group from glutamate.{57040} Oxaloacetate (30 μmol/min per 100 g for 30 minutes, i.v.) reduces blood glutamate levels, severity of neurological dysfunction, and brain edema in a rat model of closed head injury.{57043}
Brand:CaymanSKU:30280 - 25 gAvailable on backorder
Oxaloacetic acid is an α-keto acid and a key component of cellular metabolism in its conjugate base form, oxaloacetate.{57040,57041,57042} Oxaloacetate reacts with acetyl-coenzyme A (acetyl-CoA; Item No. 16160) and water to form citrate in the first step of the citric acid cycle and is regenerated by oxidation of L-malate in the final step.{57041} It is an intermediate in gluconeogenesis that is formed in mitochondria via carboxylation of pyruvate and subsequently decarboxylated and phosphorylated to form phosphoenolpyruvate.{57042} It can be converted to aspartate via addition of an amino group from glutamate.{57040} Oxaloacetate (30 μmol/min per 100 g for 30 minutes, i.v.) reduces blood glutamate levels, severity of neurological dysfunction, and brain edema in a rat model of closed head injury.{57043}
Brand:CaymanSKU:30280 - 5 gAvailable on backorder
Oxaloacetic acid is an α-keto acid and a key component of cellular metabolism in its conjugate base form, oxaloacetate.{57040,57041,57042} Oxaloacetate reacts with acetyl-coenzyme A (acetyl-CoA; Item No. 16160) and water to form citrate in the first step of the citric acid cycle and is regenerated by oxidation of L-malate in the final step.{57041} It is an intermediate in gluconeogenesis that is formed in mitochondria via carboxylation of pyruvate and subsequently decarboxylated and phosphorylated to form phosphoenolpyruvate.{57042} It can be converted to aspartate via addition of an amino group from glutamate.{57040} Oxaloacetate (30 μmol/min per 100 g for 30 minutes, i.v.) reduces blood glutamate levels, severity of neurological dysfunction, and brain edema in a rat model of closed head injury.{57043}
Brand:CaymanSKU:30280 - 50 gAvailable on backorder
Aconitase catalyzes the stereospecific isomerization of citrate to isocitrate in the first step of the citric acid cycle. It acts as an iron regulatory protein (IRP), controlling the translation of proteins involved in iron metabolism when iron is scarce and resumes aconitase activity when iron is abundant. Aconitase is now recognized as a regulator of iron-induced glutamate production.{17857} Oxalomalic acid, formed by the condensation of oxaloacetate with glyoxylate in vivo, inhibits both aconitase and NADP-dependent isocitrate dehydrogenase in the conversion of citrate to isocitrate at concentrations as low as 1 mM.{17849} At 5 mM, oxalomalic acid inhibition of aconitase leads to a decrease in the binding activity of IRP1 and a decrease in glutamate secretion in cultured lens epithelial cells, retinal pigment epithelial cells, and neurons.{17850,17851}
Brand:CaymanSKU:- Aconitase catalyzes the stereospecific isomerization of citrate to isocitrate in the first step of the citric acid cycle. It acts as an iron regulatory protein (IRP), controlling the translation of proteins involved in iron metabolism when iron is scarce and resumes aconitase activity when iron is abundant. Aconitase is now recognized as a regulator of iron-induced glutamate production.{17857} Oxalomalic acid, formed by the condensation of oxaloacetate with glyoxylate in vivo, inhibits both aconitase and NADP-dependent isocitrate dehydrogenase in the conversion of citrate to isocitrate at concentrations as low as 1 mM.{17849} At 5 mM, oxalomalic acid inhibition of aconitase leads to a decrease in the binding activity of IRP1 and a decrease in glutamate secretion in cultured lens epithelial cells, retinal pigment epithelial cells, and neurons.{17850,17851}
Brand:CaymanSKU:- Aconitase catalyzes the stereospecific isomerization of citrate to isocitrate in the first step of the citric acid cycle. It acts as an iron regulatory protein (IRP), controlling the translation of proteins involved in iron metabolism when iron is scarce and resumes aconitase activity when iron is abundant. Aconitase is now recognized as a regulator of iron-induced glutamate production.{17857} Oxalomalic acid, formed by the condensation of oxaloacetate with glyoxylate in vivo, inhibits both aconitase and NADP-dependent isocitrate dehydrogenase in the conversion of citrate to isocitrate at concentrations as low as 1 mM.{17849} At 5 mM, oxalomalic acid inhibition of aconitase leads to a decrease in the binding activity of IRP1 and a decrease in glutamate secretion in cultured lens epithelial cells, retinal pigment epithelial cells, and neurons.{17850,17851}
Brand:CaymanSKU:- Aconitase catalyzes the stereospecific isomerization of citrate to isocitrate in the first step of the citric acid cycle. It acts as an iron regulatory protein (IRP), controlling the translation of proteins involved in iron metabolism when iron is scarce and resumes aconitase activity when iron is abundant. Aconitase is now recognized as a regulator of iron-induced glutamate production.{17857} Oxalomalic acid, formed by the condensation of oxaloacetate with glyoxylate in vivo, inhibits both aconitase and NADP-dependent isocitrate dehydrogenase in the conversion of citrate to isocitrate at concentrations as low as 1 mM.{17849} At 5 mM, oxalomalic acid inhibition of aconitase leads to a decrease in the binding activity of IRP1 and a decrease in glutamate secretion in cultured lens epithelial cells, retinal pigment epithelial cells, and neurons.{17850,17851}
Brand:CaymanSKU:-
Oxamflatin is a potent inhibitor of histone deacetylases (IC50 = 15.7 nM).{18443} It has been shown to alter the expression of several genes whose products are involved in cell morphology, motility, apoptosis, and cell cycle control, reducing the proliferation of cancer cells.{18441,18442,18443}
Brand:CaymanSKU:- Oxamflatin is a potent inhibitor of histone deacetylases (IC50 = 15.7 nM).{18443} It has been shown to alter the expression of several genes whose products are involved in cell morphology, motility, apoptosis, and cell cycle control, reducing the proliferation of cancer cells.{18441,18442,18443}
Brand:CaymanSKU:- Oxamflatin is a potent inhibitor of histone deacetylases (IC50 = 15.7 nM).{18443} It has been shown to alter the expression of several genes whose products are involved in cell morphology, motility, apoptosis, and cell cycle control, reducing the proliferation of cancer cells.{18441,18442,18443}
Brand:CaymanSKU:-
Oxamyl is a carbamate pesticide and an inhibitor of acetylcholinesterase (AChE; IC50 = 1.67 μM for C. gigas enzyme).{43372} It is nematocidal, decreasing the number of P. penetrans and M. hapla per gram of alfalfa (M. sativa) root when applied to seeds at a concentration of 50 mg/ml.{43373} Oxamyl (50 and 100 μg/ml) is also toxic to citrus nematode (T. semipenetrans) larvae.{43374} In vivo, oxamyl (2.1 and 3.5 mg/kg) inhibits plasma and brain AChE, as well as liver glucose-6-phosphatase and succinic acid dehydrogenase, and reduces body weight gain in rats.{43375} Formulations containing oxamyl have been used to control nematode infestation of field crops.
Brand:CaymanSKU:25609 - 100 mgAvailable on backorder
Oxamyl is a carbamate pesticide and an inhibitor of acetylcholinesterase (AChE; IC50 = 1.67 μM for C. gigas enzyme).{43372} It is nematocidal, decreasing the number of P. penetrans and M. hapla per gram of alfalfa (M. sativa) root when applied to seeds at a concentration of 50 mg/ml.{43373} Oxamyl (50 and 100 μg/ml) is also toxic to citrus nematode (T. semipenetrans) larvae.{43374} In vivo, oxamyl (2.1 and 3.5 mg/kg) inhibits plasma and brain AChE, as well as liver glucose-6-phosphatase and succinic acid dehydrogenase, and reduces body weight gain in rats.{43375} Formulations containing oxamyl have been used to control nematode infestation of field crops.
Brand:CaymanSKU:25609 - 50 mgAvailable on backorder
Oxaprozin is a non-steroidal anti-inflammatory drug that inhibits COX-1 and COX-2 in human synovial cells with IC50 values of 2.2 and 36 μM, respectively.{23288} It has been reported to inhibit thromboxane B2 (Item No. 19030) production in human platelets (IC50 = ~2 μM) and to inhibit prostaglandin E2 (Item No. 14010) production by human synovial cells stimulated with IL-1β (IC50 = ~20 μM).{23288} It demonstrates analgesic and anti-inflammatory activity in rodent models at doses of 70-100 mg/kg.{25154}
Brand:CaymanSKU:- Oxaprozin is a non-steroidal anti-inflammatory drug that inhibits COX-1 and COX-2 in human synovial cells with IC50 values of 2.2 and 36 μM, respectively.{23288} It has been reported to inhibit thromboxane B2 (Item No. 19030) production in human platelets (IC50 = ~2 μM) and to inhibit prostaglandin E2 (Item No. 14010) production by human synovial cells stimulated with IL-1β (IC50 = ~20 μM).{23288} It demonstrates analgesic and anti-inflammatory activity in rodent models at doses of 70-100 mg/kg.{25154}
Brand:CaymanSKU:- Oxaprozin is a non-steroidal anti-inflammatory drug that inhibits COX-1 and COX-2 in human synovial cells with IC50 values of 2.2 and 36 μM, respectively.{23288} It has been reported to inhibit thromboxane B2 (Item No. 19030) production in human platelets (IC50 = ~2 μM) and to inhibit prostaglandin E2 (Item No. 14010) production by human synovial cells stimulated with IL-1β (IC50 = ~20 μM).{23288} It demonstrates analgesic and anti-inflammatory activity in rodent models at doses of 70-100 mg/kg.{25154}
Brand:CaymanSKU:-
Oxcarbazepine is a prodrug form of the antiepileptic compound 10,11-dihydro-10-hydroxy carbamazepine (Item No. 18467).{25311,45753} It inhibits high-frequency repetitive firing of rat spinal cord neurons when used at a concentration of 1 µM.{45753} Oxcarbazepine protects against electroshock-induced tonic hindlimb extension (ED50 = 10-20 mg/kg), as well as seizures induced by pentylenetetrazole (PTZ; Item No. 18682) or picrotoxin (Item No. 20771) in rodents (ED50s = 23-30 and 150-250 mg/kg, respectively). Formulations containing oxcarbazepine have been used in the treatment of epileptic seizures.
Brand:CaymanSKU:-Available on backorder
Oxcarbazepine is a prodrug form of the antiepileptic compound 10,11-dihydro-10-hydroxy carbamazepine (Item No. 18467).{25311,45753} It inhibits high-frequency repetitive firing of rat spinal cord neurons when used at a concentration of 1 µM.{45753} Oxcarbazepine protects against electroshock-induced tonic hindlimb extension (ED50 = 10-20 mg/kg), as well as seizures induced by pentylenetetrazole (PTZ; Item No. 18682) or picrotoxin (Item No. 20771) in rodents (ED50s = 23-30 and 150-250 mg/kg, respectively). Formulations containing oxcarbazepine have been used in the treatment of epileptic seizures.
Brand:CaymanSKU:-Available on backorder
Oxcarbazepine is a prodrug form of the antiepileptic compound 10,11-dihydro-10-hydroxy carbamazepine (Item No. 18467).{25311,45753} It inhibits high-frequency repetitive firing of rat spinal cord neurons when used at a concentration of 1 µM.{45753} Oxcarbazepine protects against electroshock-induced tonic hindlimb extension (ED50 = 10-20 mg/kg), as well as seizures induced by pentylenetetrazole (PTZ; Item No. 18682) or picrotoxin (Item No. 20771) in rodents (ED50s = 23-30 and 150-250 mg/kg, respectively). Formulations containing oxcarbazepine have been used in the treatment of epileptic seizures.
Brand:CaymanSKU:-Available on backorder
Oxcarbazepine is a prodrug form of the antiepileptic compound 10,11-dihydro-10-hydroxy carbamazepine (Item No. 18467).{25311,45753} It inhibits high-frequency repetitive firing of rat spinal cord neurons when used at a concentration of 1 µM.{45753} Oxcarbazepine protects against electroshock-induced tonic hindlimb extension (ED50 = 10-20 mg/kg), as well as seizures induced by pentylenetetrazole (PTZ; Item No. 18682) or picrotoxin (Item No. 20771) in rodents (ED50s = 23-30 and 150-250 mg/kg, respectively). Formulations containing oxcarbazepine have been used in the treatment of epileptic seizures.
Brand:CaymanSKU:-Available on backorder
Oxcarbazepine-d4 is intended for use as an internal standard for the quantification of oxcarbazepine (Item No. 17340) by GC- or LC-MS. Oxcarbazepine is a prodrug form of the antiepileptic compound 10,11-dihydro-10-hydroxy carbamazepine (Item No. 18467).{25311,45753} It inhibits high-frequency repetitive firing of rat spinal cord neurons when used at a concentration of 1 µM.{45753} Oxcarbazepine protects against electroshock-induced tonic hindlimb extension (ED50s = 10-20 mg/kg), as well as seizures induced by pentylenetetrazole (PTZ; Item No. 18682) or picrotoxin (Item No. 20771) in rodents (ED50s = 23-30 and 150-250 mg/kg, respectively). Formulations containing oxcarbazepine have been used in the treatment of epileptic seizures.
Brand:CaymanSKU:29995 - 1 mgAvailable on backorder
Oxfendazole is a benzimidazole anthelmintic.{58095,58096} In vivo, oxfendazole is curative in pig models of H. rubidus or A. suum infection when administered at doses of 3 and 6 mg/kg, respectively.{58095} It is lethal to H. contortus and T. circumcincta when administered to infected cattle (LD50s = 4.28 and 3.61 mg/kg of host weight, respectively).{58096} Formulations containing oxfendazole have been used in the treatment and prevention of helminth infections in livestock.
Brand:CaymanSKU:29742 - 10 mgAvailable on backorder
Oxfendazole is a benzimidazole anthelmintic.{58095,58096} In vivo, oxfendazole is curative in pig models of H. rubidus or A. suum infection when administered at doses of 3 and 6 mg/kg, respectively.{58095} It is lethal to H. contortus and T. circumcincta when administered to infected cattle (LD50s = 4.28 and 3.61 mg/kg of host weight, respectively).{58096} Formulations containing oxfendazole have been used in the treatment and prevention of helminth infections in livestock.
Brand:CaymanSKU:29742 - 25 mgAvailable on backorder
Oxfendazole is a benzimidazole anthelmintic.{58095,58096} In vivo, oxfendazole is curative in pig models of H. rubidus or A. suum infection when administered at doses of 3 and 6 mg/kg, respectively.{58095} It is lethal to H. contortus and T. circumcincta when administered to infected cattle (LD50s = 4.28 and 3.61 mg/kg of host weight, respectively).{58096} Formulations containing oxfendazole have been used in the treatment and prevention of helminth infections in livestock.
Brand:CaymanSKU:29742 - 5 mgAvailable on backorder
Oxfendazole is a benzimidazole anthelmintic.{58095,58096} In vivo, oxfendazole is curative in pig models of H. rubidus or A. suum infection when administered at doses of 3 and 6 mg/kg, respectively.{58095} It is lethal to H. contortus and T. circumcincta when administered to infected cattle (LD50s = 4.28 and 3.61 mg/kg of host weight, respectively).{58096} Formulations containing oxfendazole have been used in the treatment and prevention of helminth infections in livestock.
Brand:CaymanSKU:29742 - 50 mgAvailable on backorder
![A benzimidazole anthelmintic; inhibits binding of [3H]mebendazole to H. contortus L3 larval tubulin and inhibits mammalian tubulin polymerization (IC50s = 0.3 and 2.2 µM](https://interpriseusa.com/wp-content/uploads/2021/06/27365.png)
Oxibendazole is a benzimidazole anthelmintic.{41688} It inhibits binding of [3H]mebendazole to H. contortus L3 larval tubulin and inhibits mammalian tubulin polymerization (IC50s = 0.3 and 2.2 µM, respectively).{41688} When used in combination with the anthelmintic niclosamide (Item No. 10649), oxibendazole (15 mg/kg) reduces fecal worm egg counts in dogs and cats by greater than 90% for the nematodes T. canis, T. vulpis, A. caninum, and T. leonine.{45308} It also reduces fecal egg counts of strongyles in horses when administered at a dose of 10 mg/kg per day.{45309} Formulations containing oxibendazole have been used in the prevention and treatment of parasitic worm infections in dogs and the treatment of parasitic worm infections in horses.
Brand:CaymanSKU:27365 - 100 mgAvailable on backorder
Oxibendazole is a benzimidazole anthelmintic.{41688} It inhibits binding of [3H]mebendazole to H. contortus L3 larval tubulin and inhibits mammalian tubulin polymerization (IC50s = 0.3 and 2.2 µM, respectively).{41688} When used in combination with the anthelmintic niclosamide (Item No. 10649), oxibendazole (15 mg/kg) reduces fecal worm egg counts in dogs and cats by greater than 90% for the nematodes T. canis, T. vulpis, A. caninum, and T. leonine.{45308} It also reduces fecal egg counts of strongyles in horses when administered at a dose of 10 mg/kg per day.{45309} Formulations containing oxibendazole have been used in the prevention and treatment of parasitic worm infections in dogs and the treatment of parasitic worm infections in horses.
Brand:CaymanSKU:27365 - 25 mgAvailable on backorder
Oxibendazole is a benzimidazole anthelmintic.{41688} It inhibits binding of [3H]mebendazole to H. contortus L3 larval tubulin and inhibits mammalian tubulin polymerization (IC50s = 0.3 and 2.2 µM, respectively).{41688} When used in combination with the anthelmintic niclosamide (Item No. 10649), oxibendazole (15 mg/kg) reduces fecal worm egg counts in dogs and cats by greater than 90% for the nematodes T. canis, T. vulpis, A. caninum, and T. leonine.{45308} It also reduces fecal egg counts of strongyles in horses when administered at a dose of 10 mg/kg per day.{45309} Formulations containing oxibendazole have been used in the prevention and treatment of parasitic worm infections in dogs and the treatment of parasitic worm infections in horses.
Brand:CaymanSKU:27365 - 250 mgAvailable on backorder
Oxibendazole is a benzimidazole anthelmintic.{41688} It inhibits binding of [3H]mebendazole to H. contortus L3 larval tubulin and inhibits mammalian tubulin polymerization (IC50s = 0.3 and 2.2 µM, respectively).{41688} When used in combination with the anthelmintic niclosamide (Item No. 10649), oxibendazole (15 mg/kg) reduces fecal worm egg counts in dogs and cats by greater than 90% for the nematodes T. canis, T. vulpis, A. caninum, and T. leonine.{45308} It also reduces fecal egg counts of strongyles in horses when administered at a dose of 10 mg/kg per day.{45309} Formulations containing oxibendazole have been used in the prevention and treatment of parasitic worm infections in dogs and the treatment of parasitic worm infections in horses.
Brand:CaymanSKU:27365 - 50 mgAvailable on backorder
Oxiconazole is an antifungal imidazole that inhibits a broad spectrum of pathogenic yeasts and molds, including A. fumigatus, C. neoformans, C. albicans, and T. mentagrophytes.{25584} Its inhibitory action results from its ability to inhibit the synthesis of ergosterol, the major sterol of the fungal cell membrane.{25584}
Brand:CaymanSKU:-Available on backorder
Oxiconazole is an antifungal imidazole that inhibits a broad spectrum of pathogenic yeasts and molds, including A. fumigatus, C. neoformans, C. albicans, and T. mentagrophytes.{25584} Its inhibitory action results from its ability to inhibit the synthesis of ergosterol, the major sterol of the fungal cell membrane.{25584}
Brand:CaymanSKU:-Available on backorder
Oxiconazole is an antifungal imidazole that inhibits a broad spectrum of pathogenic yeasts and molds, including A. fumigatus, C. neoformans, C. albicans, and T. mentagrophytes.{25584} Its inhibitory action results from its ability to inhibit the synthesis of ergosterol, the major sterol of the fungal cell membrane.{25584}
Brand:CaymanSKU:-Available on backorder
The oxidation of low density lipoprotein is thought to be one of the first steps in atherosclerosis. The uptake of oxidized LDL (oxLDL) by macrophages activates pro-inflammatory mediators that promote disease progression. Cayman’s Oxidized LDL Uptake Assay Kit is a convenient tool to study modulators of cellular uptake of oxLDL. The kit employs a fluorescently tagged, human oxLDL along with myricetin, an inhibitor of uptake that reduces CD36 expression.{16736} The reagents provided in this kit are sufficient to run a single plate of cultured cells by either flow cytometry or fluorescence microscopy.
Brand:CaymanSKU:601180 - 1 eaAvailable on backorder
Oxindole is an aromatic heterocycle and starting material in the synthesis of numerous biologically active compounds including, but not limited to, anticancer, antibacterial, and antidiabetic agents, enzyme inhibitors, and channel blockers.{38727,38728}
Brand:CaymanSKU:23851 - 10 gAvailable on backorder
Oxindole is an aromatic heterocycle and starting material in the synthesis of numerous biologically active compounds including, but not limited to, anticancer, antibacterial, and antidiabetic agents, enzyme inhibitors, and channel blockers.{38727,38728}
Brand:CaymanSKU:23851 - 100 gAvailable on backorder
Oxindole is an aromatic heterocycle and starting material in the synthesis of numerous biologically active compounds including, but not limited to, anticancer, antibacterial, and antidiabetic agents, enzyme inhibitors, and channel blockers.{38727,38728}
Brand:CaymanSKU:23851 - 25 gAvailable on backorder
Oxindole is an aromatic heterocycle and starting material in the synthesis of numerous biologically active compounds including, but not limited to, anticancer, antibacterial, and antidiabetic agents, enzyme inhibitors, and channel blockers.{38727,38728}
Brand:CaymanSKU:23851 - 50 gAvailable on backorder