Cayman
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11-trans Leukotriene C4 (11-trans LTC4) is a C-11 double bond isomer of LTC4. LTC4 undergoes slow temperature-dependent isomerization to 11-trans LTC4 during storage. 11-trans LTC4 is produced in smaller amounts relative to LTC4 in ionophore-stimulated HMC-1 cells (a human mast cell line) and equine eosinophils{11135}, but not in human neutrophils or RBL-1 cells.{11184} It is nearly equipotent with LTC4 for contraction of guinea pig parenchymal and ileum.{2070,11187} In a radioligand binding assay using guinea pig ileum as a cysteinyl leukotriene receptor preparation, the pKis for LTC4 and 11-trans LTC4 were determined to be 6.42 and 6.58, respectively.{11187}
Brand:CaymanSKU:20230 -Available on backorder
11-trans Leukotriene C4 (11-trans LTC4) is a C-11 double bond isomer of LTC4. LTC4 undergoes slow temperature-dependent isomerization to 11-trans LTC4 during storage. 11-trans LTC4 is produced in smaller amounts relative to LTC4 in ionophore-stimulated HMC-1 cells (a human mast cell line) and equine eosinophils{11135}, but not in human neutrophils or RBL-1 cells.{11184} It is nearly equipotent with LTC4 for contraction of guinea pig parenchymal and ileum.{2070,11187} In a radioligand binding assay using guinea pig ileum as a cysteinyl leukotriene receptor preparation, the pKis for LTC4 and 11-trans LTC4 were determined to be 6.42 and 6.58, respectively.{11187}
Brand:CaymanSKU:20230 -Available on backorder
11-trans Leukotriene C4 (11-trans LTC4) is a C-11 double bond isomer of LTC4. LTC4 undergoes slow temperature-dependent isomerization to 11-trans LTC4 during storage. 11-trans LTC4 is produced in smaller amounts relative to LTC4 in ionophore-stimulated HMC-1 cells (a human mast cell line) and equine eosinophils{11135}, but not in human neutrophils or RBL-1 cells.{11184} It is nearly equipotent with LTC4 for contraction of guinea pig parenchymal and ileum.{2070,11187} In a radioligand binding assay using guinea pig ileum as a cysteinyl leukotriene receptor preparation, the pKis for LTC4 and 11-trans LTC4 were determined to be 6.42 and 6.58, respectively.{11187}
Brand:CaymanSKU:20230 -Available on backorder
11-trans Leukotriene D4 (11-trans LTD4) is a C-11 double bond isomer of LTD4. LTD4 undergoes slow temperature-dependent isomerization to 11-trans LTD4 during storage. 11-trans LTD4 retains about 10-25 % of the potency for contraction of guinea pig ileum, trachea and parenchyma compared to LTD4.{11179,11181} It exhibits an ED50 ranging between 12-60 nM for contraction of guinea pig trachea.{11181,11178}
Brand:CaymanSKU:20330 -Available on backorder
11-trans Leukotriene D4 (11-trans LTD4) is a C-11 double bond isomer of LTD4. LTD4 undergoes slow temperature-dependent isomerization to 11-trans LTD4 during storage. 11-trans LTD4 retains about 10-25 % of the potency for contraction of guinea pig ileum, trachea and parenchyma compared to LTD4.{11179,11181} It exhibits an ED50 ranging between 12-60 nM for contraction of guinea pig trachea.{11181,11178}
Brand:CaymanSKU:20330 -Available on backorder
11-trans Leukotriene D4 (11-trans LTD4) is a C-11 double bond isomer of LTD4. LTD4 undergoes slow temperature-dependent isomerization to 11-trans LTD4 during storage. 11-trans LTD4 retains about 10-25 % of the potency for contraction of guinea pig ileum, trachea and parenchyma compared to LTD4.{11179,11181} It exhibits an ED50 ranging between 12-60 nM for contraction of guinea pig trachea.{11181,11178}
Brand:CaymanSKU:20330 -Available on backorder
Slow isomerization of the C-11 double bond of LTE4 leads to the formation of 11-trans LTE4.{589} 11-trans LTE4 is equipotent to LTE4 in contracting guinea pig ileum.{2236}
Brand:CaymanSKU:20430 -Available on backorder
Slow isomerization of the C-11 double bond of LTE4 leads to the formation of 11-trans LTE4.{589} 11-trans LTE4 is equipotent to LTE4 in contracting guinea pig ileum.{2236}
Brand:CaymanSKU:20430 -Available on backorder
Slow isomerization of the C-11 double bond of LTE4 leads to the formation of 11-trans LTE4.{589} 11-trans LTE4 is equipotent to LTE4 in contracting guinea pig ileum.{2236}
Brand:CaymanSKU:20430 -Available on backorder
11(E)-Eicosenoic acid is a very long-chain ω-9 fatty acid that is a trans monounsaturated isomer of arachidic acid (Item No. 9000339). 11(E)-Eicosenoic acid is one of several monounsaturated 20-carbon fatty acids.{32834} The combined C20:1 isomers constitute 70% of the total fatty acid pool in jojoba seed oil isolated from plants in the Arizona desert. Unlike other eicosenoic fatty acids, 11(E)-eicosenoic acid does not inhibit leukotriene B4 (Ki = 1,150 µM in a radioligand binding assay in pig neutrophil membranes) or affect telomerase activity.{2361,38402}
Brand:CaymanSKU:22578 -Out of stock
11(E)-Eicosenoic acid is a very long-chain ω-9 fatty acid that is a trans monounsaturated isomer of arachidic acid (Item No. 9000339). 11(E)-Eicosenoic acid is one of several monounsaturated 20-carbon fatty acids.{32834} The combined C20:1 isomers constitute 70% of the total fatty acid pool in jojoba seed oil isolated from plants in the Arizona desert. Unlike other eicosenoic fatty acids, 11(E)-eicosenoic acid does not inhibit leukotriene B4 (Ki = 1,150 µM in a radioligand binding assay in pig neutrophil membranes) or affect telomerase activity.{2361,38402}
Brand:CaymanSKU:22578 -Out of stock
11(E)-Eicosenoic acid is a very long-chain ω-9 fatty acid that is a trans monounsaturated isomer of arachidic acid (Item No. 9000339). 11(E)-Eicosenoic acid is one of several monounsaturated 20-carbon fatty acids.{32834} The combined C20:1 isomers constitute 70% of the total fatty acid pool in jojoba seed oil isolated from plants in the Arizona desert. Unlike other eicosenoic fatty acids, 11(E)-eicosenoic acid does not inhibit leukotriene B4 (Ki = 1,150 µM in a radioligand binding assay in pig neutrophil membranes) or affect telomerase activity.{2361,38402}
Brand:CaymanSKU:22578 -Out of stock
11(E)-Eicosenoic acid is a very long-chain ω-9 fatty acid that is a trans monounsaturated isomer of arachidic acid (Item No. 9000339). 11(E)-Eicosenoic acid is one of several monounsaturated 20-carbon fatty acids.{32834} The combined C20:1 isomers constitute 70% of the total fatty acid pool in jojoba seed oil isolated from plants in the Arizona desert. Unlike other eicosenoic fatty acids, 11(E)-eicosenoic acid does not inhibit leukotriene B4 (Ki = 1,150 µM in a radioligand binding assay in pig neutrophil membranes) or affect telomerase activity.{2361,38402}
Brand:CaymanSKU:22578 -Out of stock
11(R)-HEDE is produced from 11Z,14Z-eicosadienoic acid by COX in a lipoxygenase-type reaction.{6937} Spectrophotometric measurement of the conjugated diene absorbance of 11(R)-HEDE is occasionally used to quantify COX activity.{6053}
Brand:CaymanSKU:37505 - 100 µgAvailable on backorder
11(R)-HEDE is produced from 11Z,14Z-eicosadienoic acid by COX in a lipoxygenase-type reaction.{6937} Spectrophotometric measurement of the conjugated diene absorbance of 11(R)-HEDE is occasionally used to quantify COX activity.{6053}
Brand:CaymanSKU:37505 - 25 µgAvailable on backorder
11(R)-HEDE is produced from 11Z,14Z-eicosadienoic acid by COX in a lipoxygenase-type reaction.{6937} Spectrophotometric measurement of the conjugated diene absorbance of 11(R)-HEDE is occasionally used to quantify COX activity.{6053}
Brand:CaymanSKU:37505 - 250 µgAvailable on backorder
11(R)-HEDE is produced from 11Z,14Z-eicosadienoic acid by COX in a lipoxygenase-type reaction.{6937} Spectrophotometric measurement of the conjugated diene absorbance of 11(R)-HEDE is occasionally used to quantify COX activity.{6053}
Brand:CaymanSKU:37505 - 50 µgAvailable on backorder
11(R)-HEPE is produced by the oxidation of EPA by 11(R)-LO. This enzymatic activity and the resulting 11(R)-hydroxy acid have been isolated from the sea urchin S. purpuratus.{584}
Brand:CaymanSKU:32505 - 100 µgAvailable on backorder
11(R)-HEPE is produced by the oxidation of EPA by 11(R)-LO. This enzymatic activity and the resulting 11(R)-hydroxy acid have been isolated from the sea urchin S. purpuratus.{584}
Brand:CaymanSKU:32505 - 25 µgAvailable on backorder
11(R)-HEPE is produced by the oxidation of EPA by 11(R)-LO. This enzymatic activity and the resulting 11(R)-hydroxy acid have been isolated from the sea urchin S. purpuratus.{584}
Brand:CaymanSKU:32505 - 50 µgAvailable on backorder
11(R)-HETE is biosynthesized by 11(R)-LOs of the sea urchin, S. purpuratus, and the fresh water hydra, H. vulgaris.{584,2263} The biological activity of 11(R)-HETE relates to oocyte maturation and tentacle regeneration, respectively, in these two species. 11(R)-HETE is also produced when aspirin-treated recombinant COX-2 is incubated with arachidonic acid.{4378} Stereochemical assignment of the (R) enantiomer is based on comparison of chiral HPLC retention times to published results. {30214}
Brand:CaymanSKU:34505 - 100 µgAvailable on backorder
11(R)-HETE is biosynthesized by 11(R)-LOs of the sea urchin, S. purpuratus, and the fresh water hydra, H. vulgaris.{584,2263} The biological activity of 11(R)-HETE relates to oocyte maturation and tentacle regeneration, respectively, in these two species. 11(R)-HETE is also produced when aspirin-treated recombinant COX-2 is incubated with arachidonic acid.{4378} Stereochemical assignment of the (R) enantiomer is based on comparison of chiral HPLC retention times to published results. {30214}
Brand:CaymanSKU:34505 - 25 µgAvailable on backorder
11(R)-HETE is biosynthesized by 11(R)-LOs of the sea urchin, S. purpuratus, and the fresh water hydra, H. vulgaris.{584,2263} The biological activity of 11(R)-HETE relates to oocyte maturation and tentacle regeneration, respectively, in these two species. 11(R)-HETE is also produced when aspirin-treated recombinant COX-2 is incubated with arachidonic acid.{4378} Stereochemical assignment of the (R) enantiomer is based on comparison of chiral HPLC retention times to published results. {30214}
Brand:CaymanSKU:34505 - 50 µgAvailable on backorder
11(S)-HEDE is isolated by the chromatographic resolution of (±)11-HEDE. There are no reports of biological activity associated with 11(S)-HEDE in the literature.
Brand:CaymanSKU:37510 - 100 µgAvailable on backorder
11(S)-HEDE is isolated by the chromatographic resolution of (±)11-HEDE. There are no reports of biological activity associated with 11(S)-HEDE in the literature.
Brand:CaymanSKU:37510 - 25 µgAvailable on backorder
11(S)-HEDE is isolated by the chromatographic resolution of (±)11-HEDE. There are no reports of biological activity associated with 11(S)-HEDE in the literature.
Brand:CaymanSKU:37510 - 250 µgAvailable on backorder
11(S)-HEDE is isolated by the chromatographic resolution of (±)11-HEDE. There are no reports of biological activity associated with 11(S)-HEDE in the literature.
Brand:CaymanSKU:37510 - 50 µgAvailable on backorder
11(S)-HEPE is a monohydroxy fatty acid derived from EPA, theoretically by the action of COX. Although its arachidonate derived congener 11(S)-HETE has been isolated from cultured neutrophils, it is not known if similar incubations with EPA can produce 11(S)-HEPE.{1088}
Brand:CaymanSKU:32510 - 100 µgAvailable on backorder
11(S)-HEPE is a monohydroxy fatty acid derived from EPA, theoretically by the action of COX. Although its arachidonate derived congener 11(S)-HETE has been isolated from cultured neutrophils, it is not known if similar incubations with EPA can produce 11(S)-HEPE.{1088}
Brand:CaymanSKU:32510 - 25 µgAvailable on backorder
11(S)-HEPE is a monohydroxy fatty acid derived from EPA, theoretically by the action of COX. Although its arachidonate derived congener 11(S)-HETE has been isolated from cultured neutrophils, it is not known if similar incubations with EPA can produce 11(S)-HEPE.{1088}
Brand:CaymanSKU:32510 - 50 µgAvailable on backorder
The synthesis of 11-HETE by rat PMNL has been reported, but the stereochemistry of the 11-HETE produced is not defined.{1088} There are no definitive reports of a mammalian 11(S)-LO. Stereochemical assignment of the (S) enantiomer is based on comparison of chiral HPLC retention times to published results.{30214}
Brand:CaymanSKU:34510 - 100 µgAvailable on backorder
The synthesis of 11-HETE by rat PMNL has been reported, but the stereochemistry of the 11-HETE produced is not defined.{1088} There are no definitive reports of a mammalian 11(S)-LO. Stereochemical assignment of the (S) enantiomer is based on comparison of chiral HPLC retention times to published results.{30214}
Brand:CaymanSKU:34510 - 25 µgAvailable on backorder
The synthesis of 11-HETE by rat PMNL has been reported, but the stereochemistry of the 11-HETE produced is not defined.{1088} There are no definitive reports of a mammalian 11(S)-LO. Stereochemical assignment of the (S) enantiomer is based on comparison of chiral HPLC retention times to published results.{30214}
Brand:CaymanSKU:34510 - 50 µgAvailable on backorder
11(Z)-Eicosenoic acid is one of several monounsaturated 20-carbon fatty acids. The combined C20:1 isomers constitute 70% of the total fatty acid pool in jojoba seed oil isolated from plants in the Arizona desert.{32834}
Brand:CaymanSKU:20606 -Available on backorder
11(Z)-Eicosenoic acid is one of several monounsaturated 20-carbon fatty acids. The combined C20:1 isomers constitute 70% of the total fatty acid pool in jojoba seed oil isolated from plants in the Arizona desert.{32834}
Brand:CaymanSKU:20606 -Available on backorder
11(Z)-Eicosenoic acid is one of several monounsaturated 20-carbon fatty acids. The combined C20:1 isomers constitute 70% of the total fatty acid pool in jojoba seed oil isolated from plants in the Arizona desert.{32834}
Brand:CaymanSKU:20606 -Available on backorder
11(Z)-Eicosenoic acid is one of several monounsaturated 20-carbon fatty acids. The combined C20:1 isomers constitute 70% of the total fatty acid pool in jojoba seed oil isolated from plants in the Arizona desert.{32834}
Brand:CaymanSKU:20606 -Available on backorder
11(Z),14(Z)-Eicosadienoic acid is an uncommon, naturally occurring PUFA. It inhibits the binding of [3H]-LTB4 to pig neutrophil membranes with a Ki of 3 µM.{2361}
Brand:CaymanSKU:90330 - 100 mgAvailable on backorder
11(Z),14(Z)-Eicosadienoic acid is an uncommon, naturally occurring PUFA. It inhibits the binding of [3H]-LTB4 to pig neutrophil membranes with a Ki of 3 µM.{2361}
Brand:CaymanSKU:90330 - 250 mgAvailable on backorder
11(Z),14(Z)-Eicosadienoic acid is an uncommon, naturally occurring PUFA. It inhibits the binding of [3H]-LTB4 to pig neutrophil membranes with a Ki of 3 µM.{2361}
Brand:CaymanSKU:90330 - 50 mgAvailable on backorder
11(Z),14(Z)-Eicosadienoic acid is an uncommon, naturally occurring PUFA. It inhibits the binding of [3H]-LTB4 to pig neutrophil membranes with a Ki of 3 µM.{2361}
Brand:CaymanSKU:90330 - 500 mgAvailable on backorder
11(Z),14(Z)-Eicosadienoic acid ethanolamide is an ethanolamide-conjugated form of 11(Z),14(Z)-eicosadienoic acid (Item No. 90330).
Brand:CaymanSKU:31024 - 1 mgAvailable on backorder
11(Z),14(Z)-Eicosadienoic acid ethanolamide is an ethanolamide-conjugated form of 11(Z),14(Z)-eicosadienoic acid (Item No. 90330).
Brand:CaymanSKU:31024 - 5 mgAvailable on backorder
11(Z),14(Z)-Eicosadienoic acid ethanolamide is an ethanolamide-conjugated form of 11(Z),14(Z)-eicosadienoic acid (Item No. 90330).
Brand:CaymanSKU:31024 - 500 µgAvailable on backorder
11(Z),14(Z)-Eicosadienoic acid methyl ester is a more lipid soluble form of the ω-6 C20-2 fatty acid 11(Z),14(Z)-eicosadienoic acid (Item No. 90330), a naturally occurring PUFA. 11(Z),14(Z)-Eicosadienoic acid competitively inhibits inosine 5’-monophosphate dehydrogenase (Ki = 3.1 µM) and inhibits the binding of LTB4 to its receptor on neutrophils (Ki = 3.0 µM).{16478,2361} Also, serum levels of eicosadienoic acids negatively correlate with degree of sleep disturbance.{16477} Eicosadienoic acids are converted by desaturases, in vivo, to eicosatrienoic acids, which are potent vasodilators.
Brand:CaymanSKU:20750 -Available on backorder
11(Z),14(Z)-Eicosadienoic acid methyl ester is a more lipid soluble form of the ω-6 C20-2 fatty acid 11(Z),14(Z)-eicosadienoic acid (Item No. 90330), a naturally occurring PUFA. 11(Z),14(Z)-Eicosadienoic acid competitively inhibits inosine 5’-monophosphate dehydrogenase (Ki = 3.1 µM) and inhibits the binding of LTB4 to its receptor on neutrophils (Ki = 3.0 µM).{16478,2361} Also, serum levels of eicosadienoic acids negatively correlate with degree of sleep disturbance.{16477} Eicosadienoic acids are converted by desaturases, in vivo, to eicosatrienoic acids, which are potent vasodilators.
Brand:CaymanSKU:20750 -Available on backorder
11(Z),14(Z)-Eicosadienoic acid methyl ester is a more lipid soluble form of the ω-6 C20-2 fatty acid 11(Z),14(Z)-eicosadienoic acid (Item No. 90330), a naturally occurring PUFA. 11(Z),14(Z)-Eicosadienoic acid competitively inhibits inosine 5’-monophosphate dehydrogenase (Ki = 3.1 µM) and inhibits the binding of LTB4 to its receptor on neutrophils (Ki = 3.0 µM).{16478,2361} Also, serum levels of eicosadienoic acids negatively correlate with degree of sleep disturbance.{16477} Eicosadienoic acids are converted by desaturases, in vivo, to eicosatrienoic acids, which are potent vasodilators.
Brand:CaymanSKU:20750 -Available on backorder
11(Z),14(Z)-Eicosadienoic acid methyl ester is a more lipid soluble form of the ω-6 C20-2 fatty acid 11(Z),14(Z)-eicosadienoic acid (Item No. 90330), a naturally occurring PUFA. 11(Z),14(Z)-Eicosadienoic acid competitively inhibits inosine 5’-monophosphate dehydrogenase (Ki = 3.1 µM) and inhibits the binding of LTB4 to its receptor on neutrophils (Ki = 3.0 µM).{16478,2361} Also, serum levels of eicosadienoic acids negatively correlate with degree of sleep disturbance.{16477} Eicosadienoic acids are converted by desaturases, in vivo, to eicosatrienoic acids, which are potent vasodilators.
Brand:CaymanSKU:20750 -Available on backorder
Eicosatrienoic Acid (20:3ω-3) is a rare polyunsaturated fatty acid of the ω-3 series. In normal humans, it represents less than 0.25% of serum phospholipid fatty acids. However, it is one of the most active essential fatty acids when assayed for the inhibition of fatty acid elongation/desaturation reactions which convert dietary C-18 fatty acids to C-20 eicosanoid precursors.{8460}
Brand:CaymanSKU:90192 - 10 mgAvailable on backorder
Eicosatrienoic Acid (20:3ω-3) is a rare polyunsaturated fatty acid of the ω-3 series. In normal humans, it represents less than 0.25% of serum phospholipid fatty acids. However, it is one of the most active essential fatty acids when assayed for the inhibition of fatty acid elongation/desaturation reactions which convert dietary C-18 fatty acids to C-20 eicosanoid precursors.{8460}
Brand:CaymanSKU:90192 - 100 mgAvailable on backorder
Eicosatrienoic Acid (20:3ω-3) is a rare polyunsaturated fatty acid of the ω-3 series. In normal humans, it represents less than 0.25% of serum phospholipid fatty acids. However, it is one of the most active essential fatty acids when assayed for the inhibition of fatty acid elongation/desaturation reactions which convert dietary C-18 fatty acids to C-20 eicosanoid precursors.{8460}
Brand:CaymanSKU:90192 - 5 mgAvailable on backorder
Eicosatrienoic Acid (20:3ω-3) is a rare polyunsaturated fatty acid of the ω-3 series. In normal humans, it represents less than 0.25% of serum phospholipid fatty acids. However, it is one of the most active essential fatty acids when assayed for the inhibition of fatty acid elongation/desaturation reactions which convert dietary C-18 fatty acids to C-20 eicosanoid precursors.{8460}
Brand:CaymanSKU:90192 - 50 mgAvailable on backorder
11(Z),14(Z),17(Z)-Eicosatrienoic acid (Item No. 90192) is a rare ω-3 PUFA in normal humans. However, it is one of the most active essential fatty acids when assayed for the inhibition of fatty acid elongation/desaturation reactions which convert dietary C-18 fatty acids to C-20 eicosanoid precursors.{8460} 11(Z),14(Z),17(Z)-Eicosatrienoic acid methyl ester is an ester version of the free acid that may be more amenable for the formulation of fatty acid-containing diets and dietary supplements.
Brand:CaymanSKU:-Available on backorder
11(Z),14(Z),17(Z)-Eicosatrienoic acid (Item No. 90192) is a rare ω-3 PUFA in normal humans. However, it is one of the most active essential fatty acids when assayed for the inhibition of fatty acid elongation/desaturation reactions which convert dietary C-18 fatty acids to C-20 eicosanoid precursors.{8460} 11(Z),14(Z),17(Z)-Eicosatrienoic acid methyl ester is an ester version of the free acid that may be more amenable for the formulation of fatty acid-containing diets and dietary supplements.
Brand:CaymanSKU:-Available on backorder
11(Z),14(Z),17(Z)-Eicosatrienoic acid (Item No. 90192) is a rare ω-3 PUFA in normal humans. However, it is one of the most active essential fatty acids when assayed for the inhibition of fatty acid elongation/desaturation reactions which convert dietary C-18 fatty acids to C-20 eicosanoid precursors.{8460} 11(Z),14(Z),17(Z)-Eicosatrienoic acid methyl ester is an ester version of the free acid that may be more amenable for the formulation of fatty acid-containing diets and dietary supplements.
Brand:CaymanSKU:-Available on backorder
11(Z),14(Z),17(Z)-Eicosatrienoic acid (Item No. 90192) is a rare ω-3 PUFA in normal humans. However, it is one of the most active essential fatty acids when assayed for the inhibition of fatty acid elongation/desaturation reactions which convert dietary C-18 fatty acids to C-20 eicosanoid precursors.{8460} 11(Z),14(Z),17(Z)-Eicosatrienoic acid methyl ester is an ester version of the free acid that may be more amenable for the formulation of fatty acid-containing diets and dietary supplements.
Brand:CaymanSKU:-Available on backorder
11β-13,14-dihydro-15-keto PGF2α is a metabolite of PGD2 (Item No. 12010) in the 15-hydroxy PGDH pathway.{11174,11176} Infusion or inhalation of tritiated PGD2 in normal males results in the appearance of peak levels of both 11β-PGF2α, as the immediate product, and 11β-13,14-dihydro-15-keto PGF2α in the plasma within 10 minutes.{11174} Homogenates of human lung metabolize PGD2 first to 11β-PGF2α and then to 11β-15-keto-PGF2α in the presence of NAD+, but not 11β-13,14-dihydro-15-keto PGF2α.{11176} Guinea pig liver and kidney homogenates metabolize PGD2 to 11β-13,14-dihydro-15-keto PGF2α, via 11β-PGF2α, in the presence of NAD+ and NADP+.{11176}
Brand:CaymanSKU:-Out of stock
11β-13,14-dihydro-15-keto PGF2α is a metabolite of PGD2 (Item No. 12010) in the 15-hydroxy PGDH pathway.{11174,11176} Infusion or inhalation of tritiated PGD2 in normal males results in the appearance of peak levels of both 11β-PGF2α, as the immediate product, and 11β-13,14-dihydro-15-keto PGF2α in the plasma within 10 minutes.{11174} Homogenates of human lung metabolize PGD2 first to 11β-PGF2α and then to 11β-15-keto-PGF2α in the presence of NAD+, but not 11β-13,14-dihydro-15-keto PGF2α.{11176} Guinea pig liver and kidney homogenates metabolize PGD2 to 11β-13,14-dihydro-15-keto PGF2α, via 11β-PGF2α, in the presence of NAD+ and NADP+.{11176}
Brand:CaymanSKU:-Out of stock
11β-13,14-dihydro-15-keto PGF2α is a metabolite of PGD2 (Item No. 12010) in the 15-hydroxy PGDH pathway.{11174,11176} Infusion or inhalation of tritiated PGD2 in normal males results in the appearance of peak levels of both 11β-PGF2α, as the immediate product, and 11β-13,14-dihydro-15-keto PGF2α in the plasma within 10 minutes.{11174} Homogenates of human lung metabolize PGD2 first to 11β-PGF2α and then to 11β-15-keto-PGF2α in the presence of NAD+, but not 11β-13,14-dihydro-15-keto PGF2α.{11176} Guinea pig liver and kidney homogenates metabolize PGD2 to 11β-13,14-dihydro-15-keto PGF2α, via 11β-PGF2α, in the presence of NAD+ and NADP+.{11176}
Brand:CaymanSKU:-Out of stock
Immunogen: Synthetic peptide from the an internal region of human 11β-HSD1 • Host: Rabbit • Species reactivity: (+) Human, mouse, and rat • Applications: IHC and WB • 11β-HSD1 catalyzes the conversion of inactive cortisone to active cortisol in adipose tissue. Over-expression of 11β-HSD1 results in visceral obesity and metabolic syndrome including insulin-resistant diabetes, hyperlipidemia, and hyperphagia.
Brand:CaymanSKU:10004303- 1 eaAvailable on backorder
Immunogen: Synthetic peptide from the an internal region of human 11β-HSD1 • Host: Rabbit • Species reactivity: (+) Human, mouse, and rat • Applications: IHC and WB • 11β-HSD1 catalyzes the conversion of inactive cortisone to active cortisol in adipose tissue. Over-expression of 11β-HSD1 results in visceral obesity and metabolic syndrome including insulin-resistant diabetes, hyperlipidemia, and hyperphagia.
Brand:CaymanSKU:10004303- 1 ea 11β-Hydroxysteroid dehydrogenase (Type 1) (11β-HSD1) catalyzes the conversion of inactive cortisone to active cortisol in adipose tissue. mRNA and protein for this enzyme have been detected in a wide range of tissues including liver, kidney, testis, lung, heart, and colon.{12000} The enzyme’s expression is developmentally regulated, suggesting its importance in regulation of glucocorticoid action during embryonic development.{11999} Over-expression of 11β-HSD1 results in visceral obesity and metabolic syndrome including insulin-resistant diabetes, hyperlipidemia, and hyperphagia.{9545} Cayman’s 11β-HSD1 Polyclonal Antibody detects a 32 kDa protein in human, mouse, and rat liver samples by western blot analysis. The antibody can be used on paraffin-embedded tissue sections to detect 11β-HSD1 expression.
Brand:CaymanSKU:10004303 - 1 eaAvailable on backorder
Immunogen: Synthetic peptide from the N-terminal region of human 11β-HSD2; Host: Rabbit; Species Reactivity: (+) Human, mouse, and rat; Application(s): IHC and WB
Brand:CaymanSKU:10004549- 1 eaAvailable on backorder
Immunogen: Synthetic peptide from the N-terminal region of human 11β-HSD2; Host: Rabbit; Species Reactivity: (+) Human, mouse, and rat; Application(s): IHC and WB
Brand:CaymanSKU:10004549- 1 ea 11β-HSD2 plays a critical role in normal physiology in the corticosteroid regulation of sodium homeostasis and the pathophysiology of hypertension by converting active cortisol to inactive cortisone. Mutation in the gene encoding 11β-HSD2 results in cortisol induction of hypertension and hypokalemia, a syndrome of apparent mineralocorticoid excess.{11854} 11β-HSD2 mRNA and protein are expressed in placenta and mineralocorticoid target tissues, particularly the kidney.{12000} In mouse, expression of this enzyme is tissue-specific and developmentally regulated, indicating the importance of the enzyme in controlling glucocorticoid-mediated maturation.{11999} Cayman’s 11β-HSD2 Polyclonal Antibody can be used for Western blotting and immunohistochemical analysis of 11β-HSD2 from samples of human, rat, and mouse. The antibody detects a band at 44 kDa in tissues such as kidney and cell lines including Caco-2 cells and HT-29 cells.
Brand:CaymanSKU:10004549 - 1 eaAvailable on backorder
Misoprostol is a widely sold analog of prostaglandin E1 (PGE1) which has potent but relatively non-selective agonist activity with respect to the prostanoid EP receptor subgroup.{8322} Misoprostol has been used therapeutically for many years in humans for the treatment of gastric ulcer disease under the Searle tradename Cytotec.{2958} 11β-Misoprostol is one of several impurities which are possible in the production of commercial lots of bulk misoprostol, and is somewhat difficult to distinguish from other impurities such as 8-iso misoprostol. The pharmacology and EP receptor binding affinity for 11β-misoprostol have not been published.
Brand:CaymanSKU:- Misoprostol is a widely sold analog of prostaglandin E1 (PGE1) which has potent but relatively non-selective agonist activity with respect to the prostanoid EP receptor subgroup.{8322} Misoprostol has been used therapeutically for many years in humans for the treatment of gastric ulcer disease under the Searle tradename Cytotec.{2958} 11β-Misoprostol is one of several impurities which are possible in the production of commercial lots of bulk misoprostol, and is somewhat difficult to distinguish from other impurities such as 8-iso misoprostol. The pharmacology and EP receptor binding affinity for 11β-misoprostol have not been published.
Brand:CaymanSKU:-
11β-Prostaglandin E1 (11β-PGE1) is an epimerized form of PGE1 at the C-11 position. 11β-PGE1 is a less potent isomer of PGE1. It is 13% and 3.6% as potent as PGE1 in contracting the rat uterus and guinea pig ileum, respectively.{4158}
Brand:CaymanSKU:- 11β-Prostaglandin E1 (11β-PGE1) is an epimerized form of PGE1 at the C-11 position. 11β-PGE1 is a less potent isomer of PGE1. It is 13% and 3.6% as potent as PGE1 in contracting the rat uterus and guinea pig ileum, respectively.{4158}
Brand:CaymanSKU:- 11β-Prostaglandin E1 (11β-PGE1) is an epimerized form of PGE1 at the C-11 position. 11β-PGE1 is a less potent isomer of PGE1. It is 13% and 3.6% as potent as PGE1 in contracting the rat uterus and guinea pig ileum, respectively.{4158}
Brand:CaymanSKU:-
11β-PGE2 is the C-11 epimer of PGE2. It is a moderate inhibitor of PGE2 binding to rat hypothalamic membranes with a Ki value of 53 nM.{1924} 11β-PGE2 also stimulates bone resorption in rats at concentrations of 10-8 to 10-6 M which is similar to PGE2.{2052} 11β-PGE2 inhibits PGE2 binding to the prostaglandin transporter protein with a Ki of 56 nM.{3806}
Brand:CaymanSKU:- 11β-PGE2 is the C-11 epimer of PGE2. It is a moderate inhibitor of PGE2 binding to rat hypothalamic membranes with a Ki value of 53 nM.{1924} 11β-PGE2 also stimulates bone resorption in rats at concentrations of 10-8 to 10-6 M which is similar to PGE2.{2052} 11β-PGE2 inhibits PGE2 binding to the prostaglandin transporter protein with a Ki of 56 nM.{3806}
Brand:CaymanSKU:- 11β-PGE2 is the C-11 epimer of PGE2. It is a moderate inhibitor of PGE2 binding to rat hypothalamic membranes with a Ki value of 53 nM.{1924} 11β-PGE2 also stimulates bone resorption in rats at concentrations of 10-8 to 10-6 M which is similar to PGE2.{2052} 11β-PGE2 inhibits PGE2 binding to the prostaglandin transporter protein with a Ki of 56 nM.{3806}
Brand:CaymanSKU:- 11β-PGE2 is the C-11 epimer of PGE2. It is a moderate inhibitor of PGE2 binding to rat hypothalamic membranes with a Ki value of 53 nM.{1924} 11β-PGE2 also stimulates bone resorption in rats at concentrations of 10-8 to 10-6 M which is similar to PGE2.{2052} 11β-PGE2 inhibits PGE2 binding to the prostaglandin transporter protein with a Ki of 56 nM.{3806}
Brand:CaymanSKU:-
11β-PGF1β is the stereoisomer of PGF1α with both C-9 and C-11 hydroxyls inverted. There are no published reports on the biological activity of this compound. 11β-PGF1β is the stereoisomer of PGF1α with both C-9 and C-11 hydroxyls inverted.
Brand:CaymanSKU:- 11β-PGF1β is the stereoisomer of PGF1α with both C-9 and C-11 hydroxyls inverted. There are no published reports on the biological activity of this compound. 11β-PGF1β is the stereoisomer of PGF1α with both C-9 and C-11 hydroxyls inverted.
Brand:CaymanSKU:-
11β-Prostaglandin F2α (11β-PGF2α) is the primary metabolite of PGD2 (Item No. 12010).{57057} It is formed from PGD2 via the NADPH-dependent aldo-keto reductase PGF synthase (PGFS; Item No. 10007940) in the liver or lung.{57058} 11β-PGF2α induces contraction of isolated cat iris sphincter, which endogenously expresses high levels of PGF2α (FP) receptors, with an EC50 value of 0.045 µM.{57057} It also induces contraction of isolated human bronchial smooth muscle when used at concentrations ranging from 0.1 to 30 µM.{1756} 11β-PGF2α (0.1 and 1 µM) induces phosphorylation of ERK and CREB, as well as increases the viability of MCF-7 breast cancer cells stably expressing the FP receptor when used at concentrations of 0.1 and 1 µM.{57059}
Brand:CaymanSKU:-Out of stock
11β-Prostaglandin F2α (11β-PGF2α) is the primary metabolite of PGD2 (Item No. 12010).{57057} It is formed from PGD2 via the NADPH-dependent aldo-keto reductase PGF synthase (PGFS; Item No. 10007940) in the liver or lung.{57058} 11β-PGF2α induces contraction of isolated cat iris sphincter, which endogenously expresses high levels of PGF2α (FP) receptors, with an EC50 value of 0.045 µM.{57057} It also induces contraction of isolated human bronchial smooth muscle when used at concentrations ranging from 0.1 to 30 µM.{1756} 11β-PGF2α (0.1 and 1 µM) induces phosphorylation of ERK and CREB, as well as increases the viability of MCF-7 breast cancer cells stably expressing the FP receptor when used at concentrations of 0.1 and 1 µM.{57059}
Brand:CaymanSKU:-Out of stock
11β-Prostaglandin F2α (11β-PGF2α) is the primary metabolite of PGD2 (Item No. 12010).{57057} It is formed from PGD2 via the NADPH-dependent aldo-keto reductase PGF synthase (PGFS; Item No. 10007940) in the liver or lung.{57058} 11β-PGF2α induces contraction of isolated cat iris sphincter, which endogenously expresses high levels of PGF2α (FP) receptors, with an EC50 value of 0.045 µM.{57057} It also induces contraction of isolated human bronchial smooth muscle when used at concentrations ranging from 0.1 to 30 µM.{1756} 11β-PGF2α (0.1 and 1 µM) induces phosphorylation of ERK and CREB, as well as increases the viability of MCF-7 breast cancer cells stably expressing the FP receptor when used at concentrations of 0.1 and 1 µM.{57059}
Brand:CaymanSKU:-Out of stock
Brand:CaymanSKU:416522 - 100 dtnAvailable on backorder
Brand:CaymanSKU:416522 - 500 dtnAvailable on backorder