Cayman
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Nodakenin is a coumarin glucoside originally isolated from P. decursivum that has anti-inflammatory, neuroprotective, and neurogenic activities.{43146,43147,43148,43149,43150} It dose-dependently reduces LPS-induced increases in TNF-α, IL-6, and IL-1β mRNA expression and protein levels and NK-κB activity and translocation in RAW 264.7 macrophages when used at concentrations ranging from 25 to 100 µM.{43147} Nodakenin (5, 10, and 20 mg/kg) prevents airway inflammation, hyper-responsiveness, and remodeling in a mouse model of chronic asthma induced by ovalbumin.{43148} It also decreases the levels of IL-4, IL-5, IL-13, as well as matrix metalloproteinase-2 (MMP-2) and MMP-9 in bronchoalveolar lavage fluid (BALF). Nodakenin increases proliferation of neural progenitor cells in the adult mouse hippocampal dentate gyrus, increases hippocampal protein levels of AKT and glycogen synthase kinase-3β (GSK-3β), and improves learning and memory in the passive avoidance test.{43150}
Brand:CaymanSKU:25213 - 5 mgAvailable on backorder
NOD1 is a member of the NACHT and leucine-rich repeat domain-containing proteins (NLR) family of innate immunity proteins. It recognizes distinct molecular patterns from bacterial ligands and activates NF-κB, stress kinases, and interferon response factors important for host defense and inflammation. Hereditary polymorphisms in the NOD1 gene are associated with asthma, inflammatory bowel disease, multiple sclerosis, and other disorders. Noditinib-1 selectively inhibits NOD1-dependent activation of NF-κB and MAPK signaling (IC50 = 0.6 μM) and also inhibits NOD1-induced IL-8 production in MCF-7 cells without affecting viability.{19893} In ex vivo dendritic cell culture, 15 μM noditinib-1 reduced cell-surface expression of CD83, CD86, and HLA-DR and inhibited expression of IL-1β, IL-6, and TNF-α. The mechanism of this inhibitor’s activity is thought to involve alteration of the subcellular targeting of NOD1.
Brand:CaymanSKU:11040 - 10 mgAvailable on backorder
NOD1 is a member of the NACHT and leucine-rich repeat domain-containing proteins (NLR) family of innate immunity proteins. It recognizes distinct molecular patterns from bacterial ligands and activates NF-κB, stress kinases, and interferon response factors important for host defense and inflammation. Hereditary polymorphisms in the NOD1 gene are associated with asthma, inflammatory bowel disease, multiple sclerosis, and other disorders. Noditinib-1 selectively inhibits NOD1-dependent activation of NF-κB and MAPK signaling (IC50 = 0.6 μM) and also inhibits NOD1-induced IL-8 production in MCF-7 cells without affecting viability.{19893} In ex vivo dendritic cell culture, 15 μM noditinib-1 reduced cell-surface expression of CD83, CD86, and HLA-DR and inhibited expression of IL-1β, IL-6, and TNF-α. The mechanism of this inhibitor’s activity is thought to involve alteration of the subcellular targeting of NOD1.
Brand:CaymanSKU:11040 - 25 mgAvailable on backorder
NOD1 is a member of the NACHT and leucine-rich repeat domain-containing proteins (NLR) family of innate immunity proteins. It recognizes distinct molecular patterns from bacterial ligands and activates NF-κB, stress kinases, and interferon response factors important for host defense and inflammation. Hereditary polymorphisms in the NOD1 gene are associated with asthma, inflammatory bowel disease, multiple sclerosis, and other disorders. Noditinib-1 selectively inhibits NOD1-dependent activation of NF-κB and MAPK signaling (IC50 = 0.6 μM) and also inhibits NOD1-induced IL-8 production in MCF-7 cells without affecting viability.{19893} In ex vivo dendritic cell culture, 15 μM noditinib-1 reduced cell-surface expression of CD83, CD86, and HLA-DR and inhibited expression of IL-1β, IL-6, and TNF-α. The mechanism of this inhibitor’s activity is thought to involve alteration of the subcellular targeting of NOD1.
Brand:CaymanSKU:11040 - 5 mgAvailable on backorder
NOD1 is a member of the NACHT and leucine-rich repeat domain-containing proteins (NLR) family of innate immunity proteins. It recognizes distinct molecular patterns from bacterial ligands and activates NF-κB, stress kinases, and interferon response factors important for host defense and inflammation. Hereditary polymorphisms in the NOD1 gene are associated with asthma, inflammatory bowel disease, multiple sclerosis, and other disorders. Noditinib-1 selectively inhibits NOD1-dependent activation of NF-κB and MAPK signaling (IC50 = 0.6 μM) and also inhibits NOD1-induced IL-8 production in MCF-7 cells without affecting viability.{19893} In ex vivo dendritic cell culture, 15 μM noditinib-1 reduced cell-surface expression of CD83, CD86, and HLA-DR and inhibited expression of IL-1β, IL-6, and TNF-α. The mechanism of this inhibitor’s activity is thought to involve alteration of the subcellular targeting of NOD1.
Brand:CaymanSKU:11040 - 50 mgAvailable on backorder
The cyanobacterium Nodularia spumigena often contaminates the drinking water of rural communities in developing countries and accumulates in mussels, flounder, and cod from the northern Baltic Sea.{14058,14059} Nodularin is a hepatotoxic monocylic pentapeptide produced by the N. spumigena.{13247} It is a potent inhibitor of protein phosphatase types 1 (PP1) and 2A (PP2A), exhibiting IC50 values of 1.8 and 0.026 nM, respectively. PP2B is inhibited to a lesser extent with an IC50 of 1.8 µM. No apparent inhibitory effect is observed with PP2C, alkaline phosphatase, acid phosphatase, insulin receptor tyrosine kinase, protein kinase A, phosphorylase kinase, or protein kinase C.{14060}
Brand:CaymanSKU:10007190 - 100 µgAvailable on backorder
Nodusmicin is a macrolide antibiotic.{35129} It has activity against antibiotic-susceptible and -resistant S. aureus with MIC values of 125, 250, and 250 μg/ml for UC-76, UC-6685, and UC-6690 strains, respectively.
Brand:CaymanSKU:23147 - 1 mgAvailable on backorder
Nodusmicin is a macrolide antibiotic.{35129} It has activity against antibiotic-susceptible and -resistant S. aureus with MIC values of 125, 250, and 250 μg/ml for UC-76, UC-6685, and UC-6690 strains, respectively.
Brand:CaymanSKU:23147 - 5 mgAvailable on backorder
Nogalamycin is an anthracycline originally isolated from S. nogalater and a DNA-intercalating agent.{47360,47361} It inhibits the DNA-unwinding and ATPase activities of P. falciparum DNA helicase 60 (IC50s = 2 and 0.5 μM, respectively) and the DNA cleavage activity of vaccinia virus topoisomerase (IC50 = 0.7 μM).{47362,47363} Nogalamycin also inhibits the growth of MCF-7 and MDA-MB-231 human breast cancer cells (IC50s = 0.242 and 0.37 μM, respectively).{47364}
Brand:CaymanSKU:27995 - 25 mgAvailable on backorder
Nogalamycin is an anthracycline originally isolated from S. nogalater and a DNA-intercalating agent.{47360,47361} It inhibits the DNA-unwinding and ATPase activities of P. falciparum DNA helicase 60 (IC50s = 2 and 0.5 μM, respectively) and the DNA cleavage activity of vaccinia virus topoisomerase (IC50 = 0.7 μM).{47362,47363} Nogalamycin also inhibits the growth of MCF-7 and MDA-MB-231 human breast cancer cells (IC50s = 0.242 and 0.37 μM, respectively).{47364}
Brand:CaymanSKU:27995 - 5 mgAvailable on backorder
Nolatrexed is a thymidylate synthase inhibitor (Ki = 11 nM).{46592} It inhibits cell growth in a panel of human and murine cancer cell lines (IC50s = 0.39-6.6 μM). Nolatrexed inhibits the growth of L1210 cells, an effect that is decreased by greater than 50-fold by the addition of exogenous thymidine. Nolatrexed (0.7 and 3.5 μM) induces cell cycle arrest at the S phase in L1210 cells. It increases life span in a thymidine kinase-deficient L5178Y/TK- murine lymphoma model when administered at doses ranging from 25 to 200 mg/kg.
Brand:CaymanSKU:29247 - 10 mgAvailable on backorder
Nolatrexed is a thymidylate synthase inhibitor (Ki = 11 nM).{46592} It inhibits cell growth in a panel of human and murine cancer cell lines (IC50s = 0.39-6.6 μM). Nolatrexed inhibits the growth of L1210 cells, an effect that is decreased by greater than 50-fold by the addition of exogenous thymidine. Nolatrexed (0.7 and 3.5 μM) induces cell cycle arrest at the S phase in L1210 cells. It increases life span in a thymidine kinase-deficient L5178Y/TK- murine lymphoma model when administered at doses ranging from 25 to 200 mg/kg.
Brand:CaymanSKU:29247 - 100 mgAvailable on backorder
Nolatrexed is a thymidylate synthase inhibitor (Ki = 11 nM).{46592} It inhibits cell growth in a panel of human and murine cancer cell lines (IC50s = 0.39-6.6 μM). Nolatrexed inhibits the growth of L1210 cells, an effect that is decreased by greater than 50-fold by the addition of exogenous thymidine. Nolatrexed (0.7 and 3.5 μM) induces cell cycle arrest at the S phase in L1210 cells. It increases life span in a thymidine kinase-deficient L5178Y/TK- murine lymphoma model when administered at doses ranging from 25 to 200 mg/kg.
Brand:CaymanSKU:29247 - 5 mgAvailable on backorder
Nolatrexed is a thymidylate synthase inhibitor (Ki = 11 nM).{46592} It inhibits cell growth in a panel of human and murine cancer cell lines (IC50s = 0.39-6.6 μM). Nolatrexed inhibits the growth of L1210 cells, an effect that is decreased by greater than 50-fold by the addition of exogenous thymidine. Nolatrexed (0.7 and 3.5 μM) induces cell cycle arrest at the S phase in L1210 cells. It increases life span in a thymidine kinase-deficient L5178Y/TK- murine lymphoma model when administered at doses ranging from 25 to 200 mg/kg.
Brand:CaymanSKU:29247 - 50 mgAvailable on backorder
Nomegestrol is a derivative of 19-norprogesterone.{57045} It increases nuclear levels of the progesterone receptor in rat uterus when administered at a dose of 1 mg/animal.
Brand:CaymanSKU:30893 - 1 mgAvailable on backorder
Nomegestrol is a derivative of 19-norprogesterone.{57045} It increases nuclear levels of the progesterone receptor in rat uterus when administered at a dose of 1 mg/animal.
Brand:CaymanSKU:30893 - 5 mgAvailable on backorder
Nomifensine is an inhibitor of norepinephrine (NE) and dopamine (DA) reuptake.{25265} It inhibits uptake of NE, DA, and serotonin (5-HT) in rat brain synaptosomes with IC50 values of 6.6, 48, and 830 nM, respectively. It is selective for DA, NE, and 5-HT uptake inhibition over binding to dopamine D2, α1- adrenergic-, 5-HT2, and muscarinic receptors (IC50s = 43,000, 1,200, 3,800, and >13,000 nM, respectively, in rat brain membranes). Nomifensine is selective for inhibition of NE over DA uptake in vivo with minimal inhibitory doses of 28 and less than 57 µmol/kg, respectively. It decreases the time Wistar Kyoto, but not Sprague-Dawley, rats spend immobile in the forced swim test but also increases locomotor activity in the open field test in Wistar Kyoto and Sprague-Dawley rats when administered at a chronic dose of 10 mg/kg.{48733}
Brand:CaymanSKU:29330 - 100 mgAvailable on backorder
Nomifensine is an inhibitor of norepinephrine (NE) and dopamine (DA) reuptake.{25265} It inhibits uptake of NE, DA, and serotonin (5-HT) in rat brain synaptosomes with IC50 values of 6.6, 48, and 830 nM, respectively. It is selective for DA, NE, and 5-HT uptake inhibition over binding to dopamine D2, α1- adrenergic-, 5-HT2, and muscarinic receptors (IC50s = 43,000, 1,200, 3,800, and >13,000 nM, respectively, in rat brain membranes). Nomifensine is selective for inhibition of NE over DA uptake in vivo with minimal inhibitory doses of 28 and less than 57 µmol/kg, respectively. It decreases the time Wistar Kyoto, but not Sprague-Dawley, rats spend immobile in the forced swim test but also increases locomotor activity in the open field test in Wistar Kyoto and Sprague-Dawley rats when administered at a chronic dose of 10 mg/kg.{48733}
Brand:CaymanSKU:29330 - 25 mgAvailable on backorder
Nomifensine is an inhibitor of norepinephrine (NE) and dopamine (DA) reuptake.{25265} It inhibits uptake of NE, DA, and serotonin (5-HT) in rat brain synaptosomes with IC50 values of 6.6, 48, and 830 nM, respectively. It is selective for DA, NE, and 5-HT uptake inhibition over binding to dopamine D2, α1- adrenergic-, 5-HT2, and muscarinic receptors (IC50s = 43,000, 1,200, 3,800, and >13,000 nM, respectively, in rat brain membranes). Nomifensine is selective for inhibition of NE over DA uptake in vivo with minimal inhibitory doses of 28 and less than 57 µmol/kg, respectively. It decreases the time Wistar Kyoto, but not Sprague-Dawley, rats spend immobile in the forced swim test but also increases locomotor activity in the open field test in Wistar Kyoto and Sprague-Dawley rats when administered at a chronic dose of 10 mg/kg.{48733}
Brand:CaymanSKU:29330 - 50 mgAvailable on backorder
Nomilin is a limonoid triterpenoid that has been found in grapefruit seeds and has diverse biological activities, including antiviral, antiproliferative, and anti-obesity properties.{42298} It dose-dependently reduces HIV-1 replication in infected human peripheral blood mononuclear cells (PBMCs; EC50 = 52.2 μM) and reduces human umbilical vein endothelial cell (HUVEC) proliferation, invasion, tube formation, and matrix metalloproteinase-2 (MMP-2) and MMP-9 activity without reducing cell viability when used at concentrations ranging from 5 to 25 µg/ml.{42299,42300} Nomilin (100 μM) increases luciferase activity 5.5-fold when the G protein-coupled receptor TGR5 is expressed in HEK293 cells with a TGR5-dependent reporter gene.{42301} It increases GST activity in the small intestinal mucosa, liver, and forestomach of mice by 4.17-, 3.44-, and 1.16-fold, respectively, when administered at a dose of 10 mg/kg.{42298} Nomilin (0.2% w/w, p.o.) completely prevents weight gain and reduces serum glucose and insulin levels by 30 and 89.8%, respectively, in mice fed a high-fat diet.{42301} It also increases the white blood cell count and the specific antibody titer in blood by approximately 10-fold in mice in response to sheep red blood cells when administered at a dose of 10 μmol/kg.{42302}
Brand:CaymanSKU:20836 -Out of stock
Nomilin is a limonoid triterpenoid that has been found in grapefruit seeds and has diverse biological activities, including antiviral, antiproliferative, and anti-obesity properties.{42298} It dose-dependently reduces HIV-1 replication in infected human peripheral blood mononuclear cells (PBMCs; EC50 = 52.2 μM) and reduces human umbilical vein endothelial cell (HUVEC) proliferation, invasion, tube formation, and matrix metalloproteinase-2 (MMP-2) and MMP-9 activity without reducing cell viability when used at concentrations ranging from 5 to 25 µg/ml.{42299,42300} Nomilin (100 μM) increases luciferase activity 5.5-fold when the G protein-coupled receptor TGR5 is expressed in HEK293 cells with a TGR5-dependent reporter gene.{42301} It increases GST activity in the small intestinal mucosa, liver, and forestomach of mice by 4.17-, 3.44-, and 1.16-fold, respectively, when administered at a dose of 10 mg/kg.{42298} Nomilin (0.2% w/w, p.o.) completely prevents weight gain and reduces serum glucose and insulin levels by 30 and 89.8%, respectively, in mice fed a high-fat diet.{42301} It also increases the white blood cell count and the specific antibody titer in blood by approximately 10-fold in mice in response to sheep red blood cells when administered at a dose of 10 μmol/kg.{42302}
Brand:CaymanSKU:20836 -Out of stock
Nomilin is a limonoid triterpenoid that has been found in grapefruit seeds and has diverse biological activities, including antiviral, antiproliferative, and anti-obesity properties.{42298} It dose-dependently reduces HIV-1 replication in infected human peripheral blood mononuclear cells (PBMCs; EC50 = 52.2 μM) and reduces human umbilical vein endothelial cell (HUVEC) proliferation, invasion, tube formation, and matrix metalloproteinase-2 (MMP-2) and MMP-9 activity without reducing cell viability when used at concentrations ranging from 5 to 25 µg/ml.{42299,42300} Nomilin (100 μM) increases luciferase activity 5.5-fold when the G protein-coupled receptor TGR5 is expressed in HEK293 cells with a TGR5-dependent reporter gene.{42301} It increases GST activity in the small intestinal mucosa, liver, and forestomach of mice by 4.17-, 3.44-, and 1.16-fold, respectively, when administered at a dose of 10 mg/kg.{42298} Nomilin (0.2% w/w, p.o.) completely prevents weight gain and reduces serum glucose and insulin levels by 30 and 89.8%, respectively, in mice fed a high-fat diet.{42301} It also increases the white blood cell count and the specific antibody titer in blood by approximately 10-fold in mice in response to sheep red blood cells when administered at a dose of 10 μmol/kg.{42302}
Brand:CaymanSKU:20836 -Out of stock
Nomilin is a limonoid triterpenoid that has been found in grapefruit seeds and has diverse biological activities, including antiviral, antiproliferative, and anti-obesity properties.{42298} It dose-dependently reduces HIV-1 replication in infected human peripheral blood mononuclear cells (PBMCs; EC50 = 52.2 μM) and reduces human umbilical vein endothelial cell (HUVEC) proliferation, invasion, tube formation, and matrix metalloproteinase-2 (MMP-2) and MMP-9 activity without reducing cell viability when used at concentrations ranging from 5 to 25 µg/ml.{42299,42300} Nomilin (100 μM) increases luciferase activity 5.5-fold when the G protein-coupled receptor TGR5 is expressed in HEK293 cells with a TGR5-dependent reporter gene.{42301} It increases GST activity in the small intestinal mucosa, liver, and forestomach of mice by 4.17-, 3.44-, and 1.16-fold, respectively, when administered at a dose of 10 mg/kg.{42298} Nomilin (0.2% w/w, p.o.) completely prevents weight gain and reduces serum glucose and insulin levels by 30 and 89.8%, respectively, in mice fed a high-fat diet.{42301} It also increases the white blood cell count and the specific antibody titer in blood by approximately 10-fold in mice in response to sheep red blood cells when administered at a dose of 10 μmol/kg.{42302}
Brand:CaymanSKU:20836 -Out of stock
Nonactin, monactin, and dinactin mixture is a macrotetralide antibiotic.{46582} This product is a mixture of the macrotetralide antibiotic homologs nonactin, monactin (Item No. 25742), and dinactin (Item No. 20752) that all act as ionophores for monovalent cations.{32001,32000,32002,43436,43437,32289} Nonactin is a mitochondrial membrane uncoupler and an inhibitor of adenine nucleotide translocase (ANT; IC50s = 4.4, 3.3, 4.7, and 3.3 µM for recombinant human ANT1-4, respectively).{46583,46584} It selectively induces apoptosis in cancer cells and induces tumor regression in mouse xenograft models expressing mutant β-catenin over cancer cells and xenografts expressing wild-type β-catenin.{46583} Monactin induces swelling of rat liver mitochondria in medium containing either potassium or sodium, stimulates respiration, and uncouples oxidative phosphorylation.{43440} It also inhibits Wnt signaling via inhibition of TCF-β-catenin transcriptional activity.{43441} Dinactin inhibits T cell proliferation and cytokine production in vitro and reduces pulmonary eosinophilia in antigen-challenged mice.{32291}
Brand:CaymanSKU:-Available on backorder
Nonactin, monactin, and dinactin mixture is a macrotetralide antibiotic.{46582} This product is a mixture of the macrotetralide antibiotic homologs nonactin, monactin (Item No. 25742), and dinactin (Item No. 20752) that all act as ionophores for monovalent cations.{32001,32000,32002,43436,43437,32289} Nonactin is a mitochondrial membrane uncoupler and an inhibitor of adenine nucleotide translocase (ANT; IC50s = 4.4, 3.3, 4.7, and 3.3 µM for recombinant human ANT1-4, respectively).{46583,46584} It selectively induces apoptosis in cancer cells and induces tumor regression in mouse xenograft models expressing mutant β-catenin over cancer cells and xenografts expressing wild-type β-catenin.{46583} Monactin induces swelling of rat liver mitochondria in medium containing either potassium or sodium, stimulates respiration, and uncouples oxidative phosphorylation.{43440} It also inhibits Wnt signaling via inhibition of TCF-β-catenin transcriptional activity.{43441} Dinactin inhibits T cell proliferation and cytokine production in vitro and reduces pulmonary eosinophilia in antigen-challenged mice.{32291}
Brand:CaymanSKU:-Available on backorder
Nonactin, monactin, and dinactin mixture is a macrotetralide antibiotic.{46582} This product is a mixture of the macrotetralide antibiotic homologs nonactin, monactin (Item No. 25742), and dinactin (Item No. 20752) that all act as ionophores for monovalent cations.{32001,32000,32002,43436,43437,32289} Nonactin is a mitochondrial membrane uncoupler and an inhibitor of adenine nucleotide translocase (ANT; IC50s = 4.4, 3.3, 4.7, and 3.3 µM for recombinant human ANT1-4, respectively).{46583,46584} It selectively induces apoptosis in cancer cells and induces tumor regression in mouse xenograft models expressing mutant β-catenin over cancer cells and xenografts expressing wild-type β-catenin.{46583} Monactin induces swelling of rat liver mitochondria in medium containing either potassium or sodium, stimulates respiration, and uncouples oxidative phosphorylation.{43440} It also inhibits Wnt signaling via inhibition of TCF-β-catenin transcriptional activity.{43441} Dinactin inhibits T cell proliferation and cytokine production in vitro and reduces pulmonary eosinophilia in antigen-challenged mice.{32291}
Brand:CaymanSKU:-Available on backorder
Nonadecanoic acid is a 19-carbon saturated fatty acid that is found in fats and vegetable oils. It has been shown to inhibit HL-60 cancer cell proliferation with an IC50 value of 68 μM.{31488}
Brand:CaymanSKU:19723 -Available on backorder
Nonadecanoic acid is a 19-carbon saturated fatty acid that is found in fats and vegetable oils. It has been shown to inhibit HL-60 cancer cell proliferation with an IC50 value of 68 μM.{31488}
Brand:CaymanSKU:19723 -Available on backorder
Nonadecanoic acid is a 19-carbon saturated fatty acid that is found in fats and vegetable oils. It has been shown to inhibit HL-60 cancer cell proliferation with an IC50 value of 68 μM.{31488}
Brand:CaymanSKU:19723 -Available on backorder
Nonadecanoic acid methyl ester is an esterified version of the free acid which is less water soluble but more amenable for the formulation of nonadecanoate-containing diets and dietary supplements. Nonadecanoic acid (Item No. 19723) is a 19-carbon saturated fatty acid that is found in fats and vegetable oils. It has been shown to inhibit HL-60 cancer cell proliferation with an IC50 value of 68 μM.{31488}
Brand:CaymanSKU:20607 -Available on backorder
Nonadecanoic acid methyl ester is an esterified version of the free acid which is less water soluble but more amenable for the formulation of nonadecanoate-containing diets and dietary supplements. Nonadecanoic acid (Item No. 19723) is a 19-carbon saturated fatty acid that is found in fats and vegetable oils. It has been shown to inhibit HL-60 cancer cell proliferation with an IC50 value of 68 μM.{31488}
Brand:CaymanSKU:20607 -Available on backorder
Nonadecanoic acid methyl ester is an esterified version of the free acid which is less water soluble but more amenable for the formulation of nonadecanoate-containing diets and dietary supplements. Nonadecanoic acid (Item No. 19723) is a 19-carbon saturated fatty acid that is found in fats and vegetable oils. It has been shown to inhibit HL-60 cancer cell proliferation with an IC50 value of 68 μM.{31488}
Brand:CaymanSKU:20607 -Available on backorder
Nonanoic acid is a medium-chain saturated fatty acid. It is a volatile compound that has been found in raw and roasted pecans.{49127} Nonanoic acid inhibits mycelial growth and spore germination in the plant pathogenic fungi M. roreri and C. perniciosa in a concentration-dependent manner.{49128} It has herbicidal activity against a variety of species, including crabgrass.{49129,49130} Nonanoic acid has been used as an internal standard for the quantification of free fatty acids in olive mill waste waters.{49131} Formulations containing nonanoic acid have been used in indoor and outdoor weed control and as cleansing and emulsifying agents in cosmetics.
Brand:CaymanSKU:26718 - 100 mgAvailable on backorder
Nonanoic acid methyl ester is an esterified form of nonanoic acid. It is found as a volatile component following thermal oxidation of conjugated linoleic acid methyl ester but not linoleic acid methyl ester.{47401} It is cytotoxic to A549 lung carcinoma cells with an LC50 value of 104.09 µg/ml.{47402} Nonanoic acid methyl ester enhances the penetration of minoxidil into isolated hamster ventral ear skin when applied at a 10% concentration ex vivo.{47403} It is a substrate for the E. coli alkane hydroxylase system (AlkBGT), which oxidizes nonanoic acid methyl ester to produce 9-hydroxy methyl nonanoate, an ω-hydroxy fatty acid ester that can be used in the production of sustainable polymers.{47404}
Brand:CaymanSKU:26719 - 1 gAvailable on backorder
Nonanoic acid methyl ester is an esterified form of nonanoic acid. It is found as a volatile component following thermal oxidation of conjugated linoleic acid methyl ester but not linoleic acid methyl ester.{47401} It is cytotoxic to A549 lung carcinoma cells with an LC50 value of 104.09 µg/ml.{47402} Nonanoic acid methyl ester enhances the penetration of minoxidil into isolated hamster ventral ear skin when applied at a 10% concentration ex vivo.{47403} It is a substrate for the E. coli alkane hydroxylase system (AlkBGT), which oxidizes nonanoic acid methyl ester to produce 9-hydroxy methyl nonanoate, an ω-hydroxy fatty acid ester that can be used in the production of sustainable polymers.{47404}
Brand:CaymanSKU:26719 - 250 mgAvailable on backorder
Nonanoic acid methyl ester is an esterified form of nonanoic acid. It is found as a volatile component following thermal oxidation of conjugated linoleic acid methyl ester but not linoleic acid methyl ester.{47401} It is cytotoxic to A549 lung carcinoma cells with an LC50 value of 104.09 µg/ml.{47402} Nonanoic acid methyl ester enhances the penetration of minoxidil into isolated hamster ventral ear skin when applied at a 10% concentration ex vivo.{47403} It is a substrate for the E. coli alkane hydroxylase system (AlkBGT), which oxidizes nonanoic acid methyl ester to produce 9-hydroxy methyl nonanoate, an ω-hydroxy fatty acid ester that can be used in the production of sustainable polymers.{47404}
Brand:CaymanSKU:26719 - 500 mgAvailable on backorder
Brand:CaymanSKU:600009 - 500 µlAvailable on backorder
Brand:CaymanSKU:600009 - 6 mlAvailable on backorder
Nonivamide is a transient receptor potential vanilloid type 1 (TRPV1) agonist and an analog of capsaicin (Item Nos. 92350 | 10010743) that has been isolated from Capsicum species.{41887,41890} It is toxic to NHBE, BEAS-2B, and BEAS-2B cells overexpressing TRPV1 (TRPV1-OE; LC50s = 160, 115, and 1 µM, respectively), increases calcium flux in TRPV1-OE cells (EC50 = 1.4 µM), and increases GADD153 mRNA expression by 7- and 6-fold when used at concentrations of 2 and 20 µM, respectively.{41890} Nonivamide (1 µM) also increases the release of dopamine and serotonin from SH-SY5Y cells in a calcium-dependent and TRPV1-independent manner.{41888} In mice, it reduces respiration when inhaled and is toxic with LD50 values of 200 and 413 mg/kg for oral and inhaled administration, respectively.{41889} Formulations containing nonivamide have been used in pepper spray weaponry for riot control.
Brand:CaymanSKU:25328 - 1 gAvailable on backorder
Nonivamide is a transient receptor potential vanilloid type 1 (TRPV1) agonist and an analog of capsaicin (Item Nos. 92350 | 10010743) that has been isolated from Capsicum species.{41887,41890} It is toxic to NHBE, BEAS-2B, and BEAS-2B cells overexpressing TRPV1 (TRPV1-OE; LC50s = 160, 115, and 1 µM, respectively), increases calcium flux in TRPV1-OE cells (EC50 = 1.4 µM), and increases GADD153 mRNA expression by 7- and 6-fold when used at concentrations of 2 and 20 µM, respectively.{41890} Nonivamide (1 µM) also increases the release of dopamine and serotonin from SH-SY5Y cells in a calcium-dependent and TRPV1-independent manner.{41888} In mice, it reduces respiration when inhaled and is toxic with LD50 values of 200 and 413 mg/kg for oral and inhaled administration, respectively.{41889} Formulations containing nonivamide have been used in pepper spray weaponry for riot control.
Brand:CaymanSKU:25328 - 10 gAvailable on backorder
Nonivamide is a transient receptor potential vanilloid type 1 (TRPV1) agonist and an analog of capsaicin (Item Nos. 92350 | 10010743) that has been isolated from Capsicum species.{41887,41890} It is toxic to NHBE, BEAS-2B, and BEAS-2B cells overexpressing TRPV1 (TRPV1-OE; LC50s = 160, 115, and 1 µM, respectively), increases calcium flux in TRPV1-OE cells (EC50 = 1.4 µM), and increases GADD153 mRNA expression by 7- and 6-fold when used at concentrations of 2 and 20 µM, respectively.{41890} Nonivamide (1 µM) also increases the release of dopamine and serotonin from SH-SY5Y cells in a calcium-dependent and TRPV1-independent manner.{41888} In mice, it reduces respiration when inhaled and is toxic with LD50 values of 200 and 413 mg/kg for oral and inhaled administration, respectively.{41889} Formulations containing nonivamide have been used in pepper spray weaponry for riot control.
Brand:CaymanSKU:25328 - 5 gAvailable on backorder
Present in nature in the form of iodide and iodate, iodine is a solid halogen at normal temperature. It is used in medicine, in the pharmaceutical and food industry. Food is the principal daily supply of iodide in human body.{35362} Iodide is important in basal metabolism and permits temperature regulation, intellectual development for children, muscular development, normal heart function and growth of skeleton. Iodide transport is the basis for an emerging approach of selective cancer cell destruction.{35363,35364} Iodide uptake from blood into thyroid follicular cells is the first step in the biosynthesis of thyroid hormones T4 and T3, known to regulate many essential biological processes.{35365,35366}Thyroid hormones are indispensable for body development. This transport is mediated by NIS (sodium iodide symporter), an intrinsic membrane glycoprotein located in the basolateral membrane of thyrocytes. Since the discovery of NIS, thorough biochemical analysis has elucidated the mechanism of basolateral iodide transport and revealed the key role of NIS in thyroid diseases such as thyroid cancer, autoimmune disease, and congenital hypothyroidism.{35367} If rate is not in the normal proportion, some diseases can be developed as underactive thyroid if the rate is too down or overactive thyroid if the rate is too up. Other diseases exist as chronic thyroiditis of Hashimoto or cancer of the thyroid gland.{35368} Iodide deficiency is at origins of many thyroid metabolism disorders, this is why it is important to control rate of iodide to prevent all of these diseases. This Iodide Assay is based on the oxido-reduction reaction: cerium(IV) is reduced by arsenic(III). The reduction of yellow (420 nm) cerium(IV) to colorless cerium(III) by arsenic(III) proceeds very slowly but traces of iodide strongly accelerate this reaction with the rate being directly proportional to iodide concentration. For a given time, decay is inversely proportional to iodide concentration in well. This method is simple and nonradioactive, and as such it can be used widely.[Bertin Catalog No. D05076.96]
Brand:CaymanSKU:25659 - 96 wellsAvailable on backorder
Nonyloxytryptamine is a potent agonist of the serotonin (5-HT) receptor 5-HT1Dβ with an EC50 value of 68 nM for adenylate cyclase activity in CHOKM6 cells transfected with the human 5-HT1Dβ receptor.{38242} It is selective for 5-HT1Dβ over 5-HT1A for its adenylate cyclase activity, with an EC50 greater than 1 μM for 5-HT1A. It binds to 5-HT1Dβ, 5-HT1A, 5-HT1B, 5-HT2A, and 5-HT2C receptors in vitro (Kis = 1.2-315 nM). Nonyloxytryptamine also inhibits reovirus-mediated cell death in a dose-dependent manner but has no effect on reovirus attachment or internalization.{38243}
Brand:CaymanSKU:21517 -Out of stock
Nonyloxytryptamine is a potent agonist of the serotonin (5-HT) receptor 5-HT1Dβ with an EC50 value of 68 nM for adenylate cyclase activity in CHOKM6 cells transfected with the human 5-HT1Dβ receptor.{38242} It is selective for 5-HT1Dβ over 5-HT1A for its adenylate cyclase activity, with an EC50 greater than 1 μM for 5-HT1A. It binds to 5-HT1Dβ, 5-HT1A, 5-HT1B, 5-HT2A, and 5-HT2C receptors in vitro (Kis = 1.2-315 nM). Nonyloxytryptamine also inhibits reovirus-mediated cell death in a dose-dependent manner but has no effect on reovirus attachment or internalization.{38243}
Brand:CaymanSKU:21517 -Out of stock
Nonyloxytryptamine is a potent agonist of the serotonin (5-HT) receptor 5-HT1Dβ with an EC50 value of 68 nM for adenylate cyclase activity in CHOKM6 cells transfected with the human 5-HT1Dβ receptor.{38242} It is selective for 5-HT1Dβ over 5-HT1A for its adenylate cyclase activity, with an EC50 greater than 1 μM for 5-HT1A. It binds to 5-HT1Dβ, 5-HT1A, 5-HT1B, 5-HT2A, and 5-HT2C receptors in vitro (Kis = 1.2-315 nM). Nonyloxytryptamine also inhibits reovirus-mediated cell death in a dose-dependent manner but has no effect on reovirus attachment or internalization.{38243}
Brand:CaymanSKU:21517 -Out of stock
nor-Mephedrone (hydrochloride) (Item No. 9000940) is an analytical reference standard categorized as a cathinone metabolite.{19963,19964} It is a metabolite of mephedrone (Item Nos. 10801 | 26277). This product is intended for research and forensic applications.
Brand:CaymanSKU:9000940 - 10 mgAvailable on backorder
nor-Mephedrone (hydrochloride) (Item No. 9000940) is an analytical reference standard categorized as a cathinone metabolite.{19963,19964} It is a metabolite of mephedrone (Item Nos. 10801 | 26277). This product is intended for research and forensic applications.
Brand:CaymanSKU:9000940 - 5 mgAvailable on backorder
nor-Mephedrone (hydrochloride) (Item No. 9000940) is an analytical reference standard categorized as a cathinone metabolite.{19963,19964} It is a metabolite of mephedrone (Item Nos. 10801 | 26277). This product is intended for research and forensic applications.
Brand:CaymanSKU:9000940 - 50 mgAvailable on backorder
L-Arginine serves as a common substrate for both nitric oxide synthase (NOS) and arginase in the cell. NOS catalyzes the oxidation of arginine to citrulline and NO with Nω-hydroxy-L-arginine (NOHA) formed as an intermediate. Arginase, on the other hand, catalyzes the hydrolysis of arginine into urea and L-ornithine. nor-NOHA (acetate) is a potent, reversible inhibitor of rat liver arginase with a Ki value of 0.5 µM, which is 20-fold lower than the Ki of 10 µM observed for NOHA.{13098} It is about 40-fold more potent than NOHA as an inhibitor of arginase from mouse macrophages, exhibiting an IC50 of 10-12 µM.{13096} nor-NOHA (acetate) is not a substrate for any of the 3 NOS isoforms and does not inhibit nNOS or iNOS.{13095, 13100}
Brand:CaymanSKU:10006861 - 1 mgAvailable on backorder
L-Arginine serves as a common substrate for both nitric oxide synthase (NOS) and arginase in the cell. NOS catalyzes the oxidation of arginine to citrulline and NO with Nω-hydroxy-L-arginine (NOHA) formed as an intermediate. Arginase, on the other hand, catalyzes the hydrolysis of arginine into urea and L-ornithine. nor-NOHA (acetate) is a potent, reversible inhibitor of rat liver arginase with a Ki value of 0.5 µM, which is 20-fold lower than the Ki of 10 µM observed for NOHA.{13098} It is about 40-fold more potent than NOHA as an inhibitor of arginase from mouse macrophages, exhibiting an IC50 of 10-12 µM.{13096} nor-NOHA (acetate) is not a substrate for any of the 3 NOS isoforms and does not inhibit nNOS or iNOS.{13095, 13100}
Brand:CaymanSKU:10006861 - 10 mgAvailable on backorder
L-Arginine serves as a common substrate for both nitric oxide synthase (NOS) and arginase in the cell. NOS catalyzes the oxidation of arginine to citrulline and NO with Nω-hydroxy-L-arginine (NOHA) formed as an intermediate. Arginase, on the other hand, catalyzes the hydrolysis of arginine into urea and L-ornithine. nor-NOHA (acetate) is a potent, reversible inhibitor of rat liver arginase with a Ki value of 0.5 µM, which is 20-fold lower than the Ki of 10 µM observed for NOHA.{13098} It is about 40-fold more potent than NOHA as an inhibitor of arginase from mouse macrophages, exhibiting an IC50 of 10-12 µM.{13096} nor-NOHA (acetate) is not a substrate for any of the 3 NOS isoforms and does not inhibit nNOS or iNOS.{13095, 13100}
Brand:CaymanSKU:10006861 - 5 mgAvailable on backorder
L-Arginine serves as a common substrate for both nitric oxide synthase (NOS) and arginase in the cell. NOS catalyzes the oxidation of arginine to citrulline and NO with Nω-hydroxy-L-arginine (NOHA) formed as an intermediate. Arginase, on the other hand, catalyzes the hydrolysis of arginine into urea and L-ornithine. nor-NOHA (acetate) is a potent, reversible inhibitor of rat liver arginase with a Ki value of 0.5 µM, which is 20-fold lower than the Ki of 10 µM observed for NOHA.{13098} It is about 40-fold more potent than NOHA as an inhibitor of arginase from mouse macrophages, exhibiting an IC50 of 10-12 µM.{13096} nor-NOHA (acetate) is not a substrate for any of the 3 NOS isoforms and does not inhibit nNOS or iNOS.{13095, 13100}
Brand:CaymanSKU:10006861 - 50 mgAvailable on backorder
Noracronycine is an alkaloid originally isolated from G. pentaphylla that has antimalarial activity.{54354,54355} It is active against P. yoelii when used at a concentration of 10 µg/ml.
Brand:CaymanSKU:31336 - 1 mgAvailable on backorder
Noracronycine is an alkaloid originally isolated from G. pentaphylla that has antimalarial activity.{54354,54355} It is active against P. yoelii when used at a concentration of 10 µg/ml.
Brand:CaymanSKU:31336 - 5 mgAvailable on backorder
Norcantharidin is a demethylated form of the protein phosphatase 1 (PP1) and PP2A inhibitor cantharidin (Item No. 14589) and a PP1 and PP2A inhibitor (IC50s = 9 and 3 µM, respectively).{46995,46996} It induces cell cycle arrest at the G2/M phase and apoptosis in HepG2, Hep3B, and Huh7 human hepatoma cell lines when used at a concentration of 5 µg/ml.{46996} Norcantharidin (500-5,000 µg/ml) reduces angiogenesis in a chick chorioallantoic membrane assay.{46997} It inhibits growth in a panel of nine human cancer cell lines, including breast, lung, skin, and glioblastoma cancer cells, with GI50 values ranging from 30 to 64 µM.{46995} Norcantharidin (28 mg/kg, i.p.) reduces tumor growth in a GBC-SD mouse xenograft model.
Brand:CaymanSKU:28457 - 1 gAvailable on backorder
Norcantharidin is a demethylated form of the protein phosphatase 1 (PP1) and PP2A inhibitor cantharidin (Item No. 14589) and a PP1 and PP2A inhibitor (IC50s = 9 and 3 µM, respectively).{46995,46996} It induces cell cycle arrest at the G2/M phase and apoptosis in HepG2, Hep3B, and Huh7 human hepatoma cell lines when used at a concentration of 5 µg/ml.{46996} Norcantharidin (500-5,000 µg/ml) reduces angiogenesis in a chick chorioallantoic membrane assay.{46997} It inhibits growth in a panel of nine human cancer cell lines, including breast, lung, skin, and glioblastoma cancer cells, with GI50 values ranging from 30 to 64 µM.{46995} Norcantharidin (28 mg/kg, i.p.) reduces tumor growth in a GBC-SD mouse xenograft model.
Brand:CaymanSKU:28457 - 5 gAvailable on backorder
Norcocaine (hydrochloride) (Item No. 28492) is an analytical reference standard categorized as a metabolite of cocaine (Item Nos. ISO60176 | 16186 | 22165).{32199,46710,46711} This product is intended for research and forensic applications.
Brand:CaymanSKU:28492 - 1 mgAvailable on backorder
Norcocaine (hydrochloride) (Item No. 28492) is an analytical reference standard categorized as a metabolite of cocaine (Item Nos. ISO60176 | 16186 | 22165).{32199,46710,46711} This product is intended for research and forensic applications.
Brand:CaymanSKU:28492 - 5 mgAvailable on backorder
Norcodeine (Item No. 23816) is an analytical reference standard that is structurally similar to known opioids. It is a major metabolite of codeine (Item No. ISO60140).{34253} This product is intended for research and forensic applications.
Brand:CaymanSKU:23816 - 10 mgAvailable on backorder
Norcodeine (Item No. 23816) is an analytical reference standard that is structurally similar to known opioids. It is a major metabolite of codeine (Item No. ISO60140).{34253} This product is intended for research and forensic applications.
Brand:CaymanSKU:23816 - 5 mgAvailable on backorder
Nordeoxycholic acid is a metabolite of the bile acid norcholic acid and a 23-carbon derivative of deoxycholic acid (Item Nos. 20756 | 18231).{57109} Levels of nordeoxycholic acid are decreased in the liver of rats in a high-fat diet model of non-alcoholic fatty liver disease (NAFLD) and serum levels are lower in men compared with women.{46416,57110} Nordeoxycholic acid has commonly been used as an internal standard for the quantification of bile acids in various sample types by GC- and LC-MS.{57111,57112}
Brand:CaymanSKU:30837 - 10 mgAvailable on backorder
Nordeoxycholic acid is a metabolite of the bile acid norcholic acid and a 23-carbon derivative of deoxycholic acid (Item Nos. 20756 | 18231).{57109} Levels of nordeoxycholic acid are decreased in the liver of rats in a high-fat diet model of non-alcoholic fatty liver disease (NAFLD) and serum levels are lower in men compared with women.{46416,57110} Nordeoxycholic acid has commonly been used as an internal standard for the quantification of bile acids in various sample types by GC- and LC-MS.{57111,57112}
Brand:CaymanSKU:30837 - 100 mgAvailable on backorder
Nordeoxycholic acid is a metabolite of the bile acid norcholic acid and a 23-carbon derivative of deoxycholic acid (Item Nos. 20756 | 18231).{57109} Levels of nordeoxycholic acid are decreased in the liver of rats in a high-fat diet model of non-alcoholic fatty liver disease (NAFLD) and serum levels are lower in men compared with women.{46416,57110} Nordeoxycholic acid has commonly been used as an internal standard for the quantification of bile acids in various sample types by GC- and LC-MS.{57111,57112}
Brand:CaymanSKU:30837 - 250 mgAvailable on backorder
Nordeoxycholic acid is a metabolite of the bile acid norcholic acid and a 23-carbon derivative of deoxycholic acid (Item Nos. 20756 | 18231).{57109} Levels of nordeoxycholic acid are decreased in the liver of rats in a high-fat diet model of non-alcoholic fatty liver disease (NAFLD) and serum levels are lower in men compared with women.{46416,57110} Nordeoxycholic acid has commonly been used as an internal standard for the quantification of bile acids in various sample types by GC- and LC-MS.{57111,57112}
Brand:CaymanSKU:30837 - 50 mgAvailable on backorder
NDGA is a non-selective lipoxygenase (LO) inhibitor which blocks cysteinyl leukotriene (CysLT) synthesis. NDGA inhibits A-23187-induced CysLT biosynthesis in rat peritoneal cells with an IC50 value of 5-7 µM.{346} The IC50 values are 3.0-5.0 µM for human platelet 12-LO and 0.91 µM for rabbit reticulocyte 15-LO.{346,1710}
Brand:CaymanSKU:70300 - 1 gAvailable on backorder
NDGA is a non-selective lipoxygenase (LO) inhibitor which blocks cysteinyl leukotriene (CysLT) synthesis. NDGA inhibits A-23187-induced CysLT biosynthesis in rat peritoneal cells with an IC50 value of 5-7 µM.{346} The IC50 values are 3.0-5.0 µM for human platelet 12-LO and 0.91 µM for rabbit reticulocyte 15-LO.{346,1710}
Brand:CaymanSKU:70300 - 5 gAvailable on backorder
NDGA is a non-selective lipoxygenase (LO) inhibitor which blocks cysteinyl leukotriene (CysLT) synthesis. NDGA inhibits A-23187-induced CysLT biosynthesis in rat peritoneal cells with an IC50 value of 5-7 µM.{346} The IC50 values are 3.0-5.0 µM for human platelet 12-LO and 0.91 µM for rabbit reticulocyte 15-LO.{346,1710}
Brand:CaymanSKU:70300 - 500 mgAvailable on backorder
Norethindrone is a synthetic progesterone (Item No. 15876) of the 19-nortestosterone class with similar effects to those of natural progesterone via activation of the progesterone receptor. It is reported to stimulate the growth of estrogen receptor (ER)-positive but not ER-negative breast cancer cells in culture.{32954}
Brand:CaymanSKU:20941 -Out of stock
Norethindrone is a synthetic progesterone (Item No. 15876) of the 19-nortestosterone class with similar effects to those of natural progesterone via activation of the progesterone receptor. It is reported to stimulate the growth of estrogen receptor (ER)-positive but not ER-negative breast cancer cells in culture.{32954}
Brand:CaymanSKU:20941 -Out of stock
Norethindrone is a synthetic progesterone (Item No. 15876) of the 19-nortestosterone class with similar effects to those of natural progesterone via activation of the progesterone receptor. It is reported to stimulate the growth of estrogen receptor (ER)-positive but not ER-negative breast cancer cells in culture.{32954}
Brand:CaymanSKU:20941 -Out of stock
Norethindrone is a synthetic progesterone (Item No. 15876) of the 19-nortestosterone class with similar effects to those of natural progesterone via activation of the progesterone receptor. It is reported to stimulate the growth of estrogen receptor (ER)-positive but not ER-negative breast cancer cells in culture.{32954}
Brand:CaymanSKU:20941 -Out of stock
Norfloxacin is a fluoroquinolone antibiotic that inhibits the growth of Gram-positive and Gram-negative bacteria (MICs = 4 and 1 μg/ml for S. aureus and P. aeruginosa, respectively).{45096} It also inhibits the growth S. pseudintermedius, S. aureus, E. coli, Pasturella, and S. canis isolates from dogs (mean MIC50s = 0.25, 1, 0.03, 1, and 1 μg/ml, respectively).{39898} Topical administration of norfloxacin (0.1% v/v) reduces corneal ulcer size in a rabbit model of P. aeruginosa corneal infection. It also prevents encrusted cystitis in bladder and increases survival in a rat model of Corynebacterium group D2 infection when administered at a dose of 80 mg/kg per day.{45097} Formulations containing norfloxacin have been used to treat urinary tract and gynecological infections.
Brand:CaymanSKU:25975 - 10 gAvailable on backorder
Norfloxacin is a fluoroquinolone antibiotic that inhibits the growth of Gram-positive and Gram-negative bacteria (MICs = 4 and 1 μg/ml for S. aureus and P. aeruginosa, respectively).{45096} It also inhibits the growth S. pseudintermedius, S. aureus, E. coli, Pasturella, and S. canis isolates from dogs (mean MIC50s = 0.25, 1, 0.03, 1, and 1 μg/ml, respectively).{39898} Topical administration of norfloxacin (0.1% v/v) reduces corneal ulcer size in a rabbit model of P. aeruginosa corneal infection. It also prevents encrusted cystitis in bladder and increases survival in a rat model of Corynebacterium group D2 infection when administered at a dose of 80 mg/kg per day.{45097} Formulations containing norfloxacin have been used to treat urinary tract and gynecological infections.
Brand:CaymanSKU:25975 - 25 gAvailable on backorder
Norfloxacin is a fluoroquinolone antibiotic that inhibits the growth of Gram-positive and Gram-negative bacteria (MICs = 4 and 1 μg/ml for S. aureus and P. aeruginosa, respectively).{45096} It also inhibits the growth S. pseudintermedius, S. aureus, E. coli, Pasturella, and S. canis isolates from dogs (mean MIC50s = 0.25, 1, 0.03, 1, and 1 μg/ml, respectively).{39898} Topical administration of norfloxacin (0.1% v/v) reduces corneal ulcer size in a rabbit model of P. aeruginosa corneal infection. It also prevents encrusted cystitis in bladder and increases survival in a rat model of Corynebacterium group D2 infection when administered at a dose of 80 mg/kg per day.{45097} Formulations containing norfloxacin have been used to treat urinary tract and gynecological infections.
Brand:CaymanSKU:25975 - 5 gAvailable on backorder
Norfloxacin is a fluoroquinolone antibiotic that inhibits the growth of Gram-positive and Gram-negative bacteria (MICs = 4 and 1 μg/ml for S. aureus and P. aeruginosa, respectively).{45096} It also inhibits the growth S. pseudintermedius, S. aureus, E. coli, Pasturella, and S. canis isolates from dogs (mean MIC50s = 0.25, 1, 0.03, 1, and 1 μg/ml, respectively).{39898} Topical administration of norfloxacin (0.1% v/v) reduces corneal ulcer size in a rabbit model of P. aeruginosa corneal infection. It also prevents encrusted cystitis in bladder and increases survival in a rat model of Corynebacterium group D2 infection when administered at a dose of 80 mg/kg per day.{45097} Formulations containing norfloxacin have been used to treat urinary tract and gynecological infections.
Brand:CaymanSKU:25975 - 50 gAvailable on backorder
Norfloxacin-d5 is intended for use as an internal standard for the quantification of norfloxacin (Item No. 25975) by GC- or LC-MS. Norfloxacin is a fluoroquinolone antibiotic that inhibits the growth of Gram-positive and Gram-negative bacteria (MICs = 4 and 1 μg/ml for S. aureus and P. aeruginosa, respectively).{45096} It also inhibits the growth S. pseudintermedius, S. aureus, E. coli, Pasturella, and S. canis isolates from dogs (mean MIC50s = 0.25, 1, 0.03, 1, and 1 μg/ml, respectively).{39898} Topical administration of norfloxacin (0.1% v/v) reduces corneal ulcer size in a rabbit model of P. aeruginosa corneal infection. It also prevents encrusted cystitis in bladder and increases survival in a rat model of Corynebacterium group D2 infection when administered at a dose of 80 mg/kg per day.{45097} Formulations containing norfloxacin have been used to treat urinary tract and gynecological infections.
Brand:CaymanSKU:28521 - 1 mgAvailable on backorder
Norfloxacin-d5 is intended for use as an internal standard for the quantification of norfloxacin (Item No. 25975) by GC- or LC-MS. Norfloxacin is a fluoroquinolone antibiotic that inhibits the growth of Gram-positive and Gram-negative bacteria (MICs = 4 and 1 μg/ml for S. aureus and P. aeruginosa, respectively).{45096} It also inhibits the growth S. pseudintermedius, S. aureus, E. coli, Pasturella, and S. canis isolates from dogs (mean MIC50s = 0.25, 1, 0.03, 1, and 1 μg/ml, respectively).{39898} Topical administration of norfloxacin (0.1% v/v) reduces corneal ulcer size in a rabbit model of P. aeruginosa corneal infection. It also prevents encrusted cystitis in bladder and increases survival in a rat model of Corynebacterium group D2 infection when administered at a dose of 80 mg/kg per day.{45097} Formulations containing norfloxacin have been used to treat urinary tract and gynecological infections.
Brand:CaymanSKU:28521 - 10 mgAvailable on backorder
Norfloxacin-d5 is intended for use as an internal standard for the quantification of norfloxacin (Item No. 25975) by GC- or LC-MS. Norfloxacin is a fluoroquinolone antibiotic that inhibits the growth of Gram-positive and Gram-negative bacteria (MICs = 4 and 1 μg/ml for S. aureus and P. aeruginosa, respectively).{45096} It also inhibits the growth S. pseudintermedius, S. aureus, E. coli, Pasturella, and S. canis isolates from dogs (mean MIC50s = 0.25, 1, 0.03, 1, and 1 μg/ml, respectively).{39898} Topical administration of norfloxacin (0.1% v/v) reduces corneal ulcer size in a rabbit model of P. aeruginosa corneal infection. It also prevents encrusted cystitis in bladder and increases survival in a rat model of Corynebacterium group D2 infection when administered at a dose of 80 mg/kg per day.{45097} Formulations containing norfloxacin have been used to treat urinary tract and gynecological infections.
Brand:CaymanSKU:28521 - 5 mgAvailable on backorder
Norfluoxetine is an active metabolite of the antidepressant fluoxetine that inhibits serotonin uptake with a pKi value of 7.35.{25776} The S-enantiomer of norfluoxetine has 20-times higher serotonin reuptake blocking potency than the R-enantiomer (pKis = 7.86 versus 6.51, respectively).{25777,25776}
Brand:CaymanSKU:- Norfluoxetine is an active metabolite of the antidepressant fluoxetine that inhibits serotonin uptake with a pKi value of 7.35.{25776} The S-enantiomer of norfluoxetine has 20-times higher serotonin reuptake blocking potency than the R-enantiomer (pKis = 7.86 versus 6.51, respectively).{25777,25776}
Brand:CaymanSKU:- Norfluoxetine is an active metabolite of the antidepressant fluoxetine that inhibits serotonin uptake with a pKi value of 7.35.{25776} The S-enantiomer of norfluoxetine has 20-times higher serotonin reuptake blocking potency than the R-enantiomer (pKis = 7.86 versus 6.51, respectively).{25777,25776}
Brand:CaymanSKU:-