Cayman
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Neuropeptide Y (NPY) is a peptide abundantly distributed throughout the central and peripheral nervous systems that plays a major role in controlling appetite, blood pressure, cardiac contractility, and intestinal secretion.{5565} Five subtypes of the NPY receptor have been identified. Subtypes Y1 and Y5 have known roles in the stimulation of feeding while Y2 and Y4 seem to have roles in satiety.{5565} NPY has also been shown to interact with the immune system, promoting gastrointestinal inflammation, as well as exhibiting an antimicrobial effect against several gut bacteria.{24276}
Brand:CaymanSKU:- Neuropeptide Y (NPY) is a peptide abundantly distributed throughout the central and peripheral nervous systems that plays a major role in controlling appetite, blood pressure, cardiac contractility, and intestinal secretion.{5565} Five subtypes of the NPY receptor have been identified. Subtypes Y1 and Y5 have known roles in the stimulation of feeding while Y2 and Y4 seem to have roles in satiety.{5565} NPY has also been shown to interact with the immune system, promoting gastrointestinal inflammation, as well as exhibiting an antimicrobial effect against several gut bacteria.{24276}
Brand:CaymanSKU:- Neuropeptide Y (NPY) is a peptide abundantly distributed throughout the central and peripheral nervous systems that plays a major role in controlling appetite, blood pressure, cardiac contractility, and intestinal secretion.{5565} Five subtypes of the NPY receptor have been identified. Subtypes Y1 and Y5 have known roles in the stimulation of feeding while Y2 and Y4 seem to have roles in satiety.{5565} NPY has also been shown to interact with the immune system, promoting gastrointestinal inflammation, as well as exhibiting an antimicrobial effect against several gut bacteria.{24276}
Brand:CaymanSKU:-
Neutrophil elastase is stored within cytoplasmic azurophilic granules in the neutrophil and released upon stimulation by pathogens where it acts either as free protein or is associated with networks of extracellular traps (NET). Together with other proteases released from activated neutrophils, neutrophil elastase plays a critical role in degrading invading pathogens and thus provides the earliest line of defense in the immune system. It is thought to play a critical role in tumor invasion and metastasis as well as other inflammatory conditions. Cayman’s Neutrophil Elastase Activity Assay kit is designed to be used to study compounds regulating elastase release in neutrophils. The kit employs a specific non-fluorescent elastase substrate, (Z-Ala-Ala-Ala-Ala)2Rh110, which is selectively cleaved by elastase to yield the highly fluorescent compound R110, which can be analyzed with an excitation wavelength of 485 nm and emission wavelength of 525 nm. Reagents needed to isolate neutrophils from whole blood are included in the kit, as is PMA, which is known to stimulate elastase release from neutrophils.
Brand:CaymanSKU:600610 - 2 x 96 wellsAvailable on backorder
Neutrophil elastase is stored within cytoplasmic azurophilic granules in the neutrophil and released upon stimulation by pathogens where it acts either as free protein or is associated with neutrophil extracellular traps (NETs). Together with other proteases released from activated neutrophils, neutrophil elastase plays a critical role in degrading invading pathogens and thus provides the earliest line of defense in the immune system. Neutrophil elastase inhibitor is an N-benzoylindazole derivative that selectively targets the binding domain of neutrophil elastase (IC50 = 7 nM).{23600} It has been shown to inhibit additional serine proteases, thrombin and urokinase, only at higher, micromolar concentrations (IC50s = 1.9 and 6.6 µM, respectively).{23600}
Brand:CaymanSKU:- Neutrophil elastase is stored within cytoplasmic azurophilic granules in the neutrophil and released upon stimulation by pathogens where it acts either as free protein or is associated with neutrophil extracellular traps (NETs). Together with other proteases released from activated neutrophils, neutrophil elastase plays a critical role in degrading invading pathogens and thus provides the earliest line of defense in the immune system. Neutrophil elastase inhibitor is an N-benzoylindazole derivative that selectively targets the binding domain of neutrophil elastase (IC50 = 7 nM).{23600} It has been shown to inhibit additional serine proteases, thrombin and urokinase, only at higher, micromolar concentrations (IC50s = 1.9 and 6.6 µM, respectively).{23600}
Brand:CaymanSKU:- Neutrophil elastase is stored within cytoplasmic azurophilic granules in the neutrophil and released upon stimulation by pathogens where it acts either as free protein or is associated with neutrophil extracellular traps (NETs). Together with other proteases released from activated neutrophils, neutrophil elastase plays a critical role in degrading invading pathogens and thus provides the earliest line of defense in the immune system. Neutrophil elastase inhibitor is an N-benzoylindazole derivative that selectively targets the binding domain of neutrophil elastase (IC50 = 7 nM).{23600} It has been shown to inhibit additional serine proteases, thrombin and urokinase, only at higher, micromolar concentrations (IC50s = 1.9 and 6.6 µM, respectively).{23600}
Brand:CaymanSKU:- Neutrophil elastase is stored within cytoplasmic azurophilic granules in the neutrophil and released upon stimulation by pathogens where it acts either as free protein or is associated with neutrophil extracellular traps (NETs). Together with other proteases released from activated neutrophils, neutrophil elastase plays a critical role in degrading invading pathogens and thus provides the earliest line of defense in the immune system. Neutrophil elastase inhibitor is an N-benzoylindazole derivative that selectively targets the binding domain of neutrophil elastase (IC50 = 7 nM).{23600} It has been shown to inhibit additional serine proteases, thrombin and urokinase, only at higher, micromolar concentrations (IC50s = 1.9 and 6.6 µM, respectively).{23600}
Brand:CaymanSKU:-
Myeloperoxidase (MPO), released from neutrophils to degrade invading pathogens, provides one of the earliest lines of defense in innate immunity. It catalyzes the hydrogen peroxide-mediated oxidation of halide ions to products such as hypochlorous acid (HOCl). These reactive products participate in a variety of secondary reactions which in turn lead to modifications of proteins and destruction of the extracellular matrix. Cayman’s Neutrophil Myeloperoxidase Activity Assay kit utilizes 3,3′,5,5′-tetramethyl-benzidine (TMB) as a chromogenic substrate, which upon reacting with MPO, yields a blue color detectable by its absorbance at 650 nm. The color intensity is proportional to the amount of MPO in the sample. Reagents needed to isolate neutrophils from whole blood are included in the kit, as is PMA, which is known to stimulate MPO release from neutrophils. A specific inhibitor for MPO, 4-aminobenzhydrazide (ABH), is also included in the kit for verifying the specificity of the assay.
Brand:CaymanSKU:600620 - 2 x 96 wellsAvailable on backorder
Respiratory burst, or the rapid generation of reactive oxygen species from immune cells, is crucial for the destruction of invading microorganisms by phagocytes. During this process, professional phagocytes convert molecular oxygen to superoxide anions through the action of NADPH oxidase, which is then converted to reactive oxygen species with potent antimicrobial activity. Cayman’s Neutrophil/Monocyte Respiratory Burst Assay Kit provides PMA, dihydrorhodamine 123, and additional reagents necessary for inducing and quantifying a respiratory burst response in neutrophils and monocytes by flow cytometry. The assay can be performed on whole blood or on cells in various types of cell culture media. Because the assay reagents are not species-specific, this assay can be used in any species or cell type capable of producing a NADPH oxidase-dependent respiratory burst response.
Brand:CaymanSKU:601130 - 1 eaAvailable on backorder
Nevirapine is a non-nucleoside reverse transcriptase inhibitor (NNRTI).{22819} It binds to HIV-1 reverse transcriptase and inhibits RNA plus-strand initiation (IC50 = 0.45 μM). Nevirapine prevents seroconversion and viremia in a chimpanzee model of HIV-1 infection.{49140} Formulations containing nevirapine have been used in combination therapy for the treatment of HIV-1 infection.
Brand:CaymanSKU:- Nevirapine is a non-nucleoside reverse transcriptase inhibitor (NNRTI).{22819} It binds to HIV-1 reverse transcriptase and inhibits RNA plus-strand initiation (IC50 = 0.45 μM). Nevirapine prevents seroconversion and viremia in a chimpanzee model of HIV-1 infection.{49140} Formulations containing nevirapine have been used in combination therapy for the treatment of HIV-1 infection.
Brand:CaymanSKU:- Nevirapine is a non-nucleoside reverse transcriptase inhibitor (NNRTI).{22819} It binds to HIV-1 reverse transcriptase and inhibits RNA plus-strand initiation (IC50 = 0.45 μM). Nevirapine prevents seroconversion and viremia in a chimpanzee model of HIV-1 infection.{49140} Formulations containing nevirapine have been used in combination therapy for the treatment of HIV-1 infection.
Brand:CaymanSKU:- Nevirapine is a non-nucleoside reverse transcriptase inhibitor (NNRTI).{22819} It binds to HIV-1 reverse transcriptase and inhibits RNA plus-strand initiation (IC50 = 0.45 μM). Nevirapine prevents seroconversion and viremia in a chimpanzee model of HIV-1 infection.{49140} Formulations containing nevirapine have been used in combination therapy for the treatment of HIV-1 infection.
Brand:CaymanSKU:-
Nevirapine-d4 is intended for use as an internal standard for the quantification of nevirapine (Item No. 15117) by GC- or LC-MS. Nevirapine is a non-nucleoside reverse transcriptase inhibitor (NNRTI).{22819} It binds to HIV-1 reverse transcriptase and inhibits RNA plus-strand initiation (IC50 = 0.45 μM). Nevirapine prevents seroconversion and viremia in a chimpanzee model of HIV-1 infection.{49140} Formulations containing nevirapine have been used in combination therapy for the treatment of HIV-1 infection.
Brand:CaymanSKU:28093 - 1 mgAvailable on backorder
Nevirapine-d4 is intended for use as an internal standard for the quantification of nevirapine (Item No. 15117) by GC- or LC-MS. Nevirapine is a non-nucleoside reverse transcriptase inhibitor (NNRTI).{22819} It binds to HIV-1 reverse transcriptase and inhibits RNA plus-strand initiation (IC50 = 0.45 μM). Nevirapine prevents seroconversion and viremia in a chimpanzee model of HIV-1 infection.{49140} Formulations containing nevirapine have been used in combination therapy for the treatment of HIV-1 infection.
Brand:CaymanSKU:28093 - 5 mgAvailable on backorder
Nexinhib20 is an inhibitor of the protein-protein interaction between the small GTPase Rab27a and its effector JFC1 (IC50 = 2.6 µM).{46766} It inhibits myeloperoxidase (MPO) secretion induced by granulocyte macrophage colony-stimulating factor (GM-CSF) and fMLP in isolated human neutrophils (IC50 = 0.33 µM). Nexinhib20 (30 mg/kg) reduces LPS-induced increases in plasma MPO levels, as well as LPS-induced hepatic and renal neutrophil infiltration in a mouse model of endotoxin-induced systemic inflammation.
Brand:CaymanSKU:29899 - 1 mgAvailable on backorder
Nexinhib20 is an inhibitor of the protein-protein interaction between the small GTPase Rab27a and its effector JFC1 (IC50 = 2.6 µM).{46766} It inhibits myeloperoxidase (MPO) secretion induced by granulocyte macrophage colony-stimulating factor (GM-CSF) and fMLP in isolated human neutrophils (IC50 = 0.33 µM). Nexinhib20 (30 mg/kg) reduces LPS-induced increases in plasma MPO levels, as well as LPS-induced hepatic and renal neutrophil infiltration in a mouse model of endotoxin-induced systemic inflammation.
Brand:CaymanSKU:29899 - 10 mgAvailable on backorder
Nexinhib20 is an inhibitor of the protein-protein interaction between the small GTPase Rab27a and its effector JFC1 (IC50 = 2.6 µM).{46766} It inhibits myeloperoxidase (MPO) secretion induced by granulocyte macrophage colony-stimulating factor (GM-CSF) and fMLP in isolated human neutrophils (IC50 = 0.33 µM). Nexinhib20 (30 mg/kg) reduces LPS-induced increases in plasma MPO levels, as well as LPS-induced hepatic and renal neutrophil infiltration in a mouse model of endotoxin-induced systemic inflammation.
Brand:CaymanSKU:29899 - 25 mgAvailable on backorder
Nexinhib20 is an inhibitor of the protein-protein interaction between the small GTPase Rab27a and its effector JFC1 (IC50 = 2.6 µM).{46766} It inhibits myeloperoxidase (MPO) secretion induced by granulocyte macrophage colony-stimulating factor (GM-CSF) and fMLP in isolated human neutrophils (IC50 = 0.33 µM). Nexinhib20 (30 mg/kg) reduces LPS-induced increases in plasma MPO levels, as well as LPS-induced hepatic and renal neutrophil infiltration in a mouse model of endotoxin-induced systemic inflammation.
Brand:CaymanSKU:29899 - 5 mgAvailable on backorder
Nexturastat A is a potent inhibitor of HDAC6 (IC50 = 5.02 nM) that displays high selectivity over all other HDACs.{29222} It dose-dependently induces hyperacetylation of α-tubulin in B16 murine melanoma cells without elevating histone H3 acetylation.{29222} Nexturastat A is cell-permeable and inhibits the proliferation of B16 cells (GI50 = 14.3 µM).{29222}
Brand:CaymanSKU:-Out of stock
Nexturastat A is a potent inhibitor of HDAC6 (IC50 = 5.02 nM) that displays high selectivity over all other HDACs.{29222} It dose-dependently induces hyperacetylation of α-tubulin in B16 murine melanoma cells without elevating histone H3 acetylation.{29222} Nexturastat A is cell-permeable and inhibits the proliferation of B16 cells (GI50 = 14.3 µM).{29222}
Brand:CaymanSKU:-Out of stock
Nexturastat A is a potent inhibitor of HDAC6 (IC50 = 5.02 nM) that displays high selectivity over all other HDACs.{29222} It dose-dependently induces hyperacetylation of α-tubulin in B16 murine melanoma cells without elevating histone H3 acetylation.{29222} Nexturastat A is cell-permeable and inhibits the proliferation of B16 cells (GI50 = 14.3 µM).{29222}
Brand:CaymanSKU:-Out of stock
Nexturastat A is a potent inhibitor of HDAC6 (IC50 = 5.02 nM) that displays high selectivity over all other HDACs.{29222} It dose-dependently induces hyperacetylation of α-tubulin in B16 murine melanoma cells without elevating histone H3 acetylation.{29222} Nexturastat A is cell-permeable and inhibits the proliferation of B16 cells (GI50 = 14.3 µM).{29222}
Brand:CaymanSKU:-Out of stock
Cayman’s NF-κB (human p50) Transcription Factor Assay is a non-radioactive, sensitive method for detecting specific transcription factor DNA binding activity in nuclear extracts and whole cell lysates. A 96-well enzyme-linked immunosorbent assay (ELISA) replaces the cumbersome radioactive electrophoretic mobility shift assay (EMSA). A specific double stranded DNA (dsDNA) sequence containing the NF-κB response element is immobilized to the wells of a 96-well plate. NF-κB contained in a nuclear extract, binds specifically to the NF-κB response element. NF-κB (p50) is detected by addition of specific primary antibody directed against NF-κB (p50). A secondary antibody conjugated to HRP is added to provide a sensitive colorimetric readout at 450 nm. The Cayman Chemical NF-κB (human p50) Transcription Factor Assay detects human NF-κB (p50). It will not cross-react with NF-κB (p65).
Brand:CaymanSKU:10006912 - 96 wellsAvailable on backorder
NF-κB is a transcription factor activated by various extra and intracellular stimuli such as cytokines, UV radiation, stress, injury, and by bacterial and viral products. It is involved in regulation of various cellular events including cell growth, differentiation, proliferation, apoptosis, and inflammation. NF-κB1 (p50), a 50 kDa functional sub-unit of NF-κB, is a member of the Rel protein family. It is synthesized as a p105 precursor protein and consists of an N-terminal conserved RHD-region containing a nuclear localization signal, DNA-binding and dimerization domains. NF-κB (p50) forms homodimers or heterodimerizes with p65, forming the functional NF-κB factor. NF-κB (p50) directs the nuclear translocation of NF-κB and is instrumental in its DNA-binding. A pathological role of NF-κB has been suggested in AIDS, hematogenic cancer cell metastasis, and rheumatoid arthritis.
Brand:CaymanSKU:13755 - 1 eaAvailable on backorder
Antigen: a portion of amino acids 150-200 of human NF-κB (p50) • Host: mouse, clone 2J10D7 • Isotype: IgG1κ • Cross-Reactivity: (+) human NF-κB (p50) • Application(s): IHC and WB • NF-κB1 (p50) is a 50 kDa functional sub-unit of NF-κB that forms homodimers or heterodimerizes with p65, forming the functional NF-κB factor. NF-κB (p50) directs the nuclear translocation of NF-κB and is instrumental in its DNA-binding.
Brand:CaymanSKU:13755- 1 eaAvailable on backorder
Antigen: a portion of amino acids 150-200 of human NF-κB (p50) • Host: mouse, clone 2J10D7 • Isotype: IgG1κ • Cross-Reactivity: (+) human NF-κB (p50) • Application(s): IHC and WB • NF-κB1 (p50) is a 50 kDa functional sub-unit of NF-κB that forms homodimers or heterodimerizes with p65, forming the functional NF-κB factor. NF-κB (p50) directs the nuclear translocation of NF-κB and is instrumental in its DNA-binding.
Brand:CaymanSKU:13755- 1 ea
NF-κB p65 is a ubiquitously expressed transcription factor that is a subunit of the NF-κB complex and is encoded by the RELA gene in humans.{53059} It is composed of an N-terminal Rel homology domain, which contains the nuclear localization signal (NLS), and mediates dimerization, nuclear localization, and DNA and protein interactions, and two C-terminal transactivation domains that are subject to a variety of post-translational modifications and regulate the transcriptional activity of p65.{53059,53060} NF-κB p65 regulates the expression of a large number of genes in response to inflammatory and environmental cues that play critical roles in innate and adaptive immunity and cellular differentiation.{53060} Silencing of Rela induces tumor cell apoptosis in a murine Lewis lung carcinoma model, and RELA silencing in THP-1 monocytes decreases secreted levels of IL-1β and TNF-α induced by LPS.{53061,53062} Genome-wide deletion of Rela in mice is embryonic lethal.{5321} NF-κB p65 is overexpressed in the inflamed joints of patients with rheumatoid arthritis, and naïve CD4 T cells isolated from the whole blood of patients with multiple sclerosis have increased phosphorylation of NF-κB p65.{53065,53066} Cayman’s NF-κB (p65) Monoclonal Antibody – Biotinylated (Clone 112A1021) can be used for ELISA applications. The antibody recognizes NF-κB (p65) at 65 kDa from human, mouse, and rat samples.
Brand:CaymanSKU:13756 - 1 eaAvailable on backorder
Immunogen: Synthetic peptide from the C-terminal region of human NF-κB (p65) • Host: Mouse • Species Reactivity: (+) Human, mouse, rat • Applications: ELISA • MW = 65 kDa
Brand:CaymanSKU:13756- 1 eaAvailable on backorder
Immunogen: Synthetic peptide from the C-terminal region of human NF-κB (p65) • Host: Mouse • Species Reactivity: (+) Human, mouse, rat • Applications: ELISA • MW = 65 kDa
Brand:CaymanSKU:13756- 1 ea
NF-κB p65 is a ubiquitously expressed transcription factor that is a subunit of the NF-κB complex and is encoded by the RELA gene in humans.{53059} It is composed of an N-terminal Rel homology domain, which contains the nuclear localization signal (NLS), and mediates dimerization, nuclear localization, and DNA and protein interactions, and two C-terminal transactivation domains that are subject to a variety of post-translational modifications and regulate the transcriptional activity of p65.{53059,53060} NF-κB p65 regulates the expression of a large number of genes in response to inflammatory and environmental cues that play critical roles in innate and adaptive immunity and cellular differentiation.{53060} Silencing of Rela induces tumor cell apoptosis in a murine Lewis lung carcinoma model, and RELA silencing in THP-1 monocytes decreases secreted levels of IL-1β and TNF-α induced by LPS.{53061,53062} Genome-wide deletion of Rela in mice is embryonic lethal.{5321} NF-κB p65 is overexpressed in the inflamed joints of patients with rheumatoid arthritis, and naïve CD4 T cells isolated from the whole blood of patients with multiple sclerosis have increased phosphorylation of NF-κB p65.{53065,53066} Cayman’s NF-κB (p65) Monoclonal Antibody (Clone 112A1021) can be used for flow cytometry (FC), immunohistochemistry (IHC), and Western blot (WB) applications. The antibody recognizes NF-κB (p65) from human, mouse, and rat samples.
Brand:CaymanSKU:13752 - 1 eaAvailable on backorder
Immunogen: Peptide from the C-terminal region of human NF-κB (p65) • Host: Mouse • Species Reactivity: (+) Human, Mouse, Rat • Cross Reactivity: None listed • Applications: FC, IHC, WB
Brand:CaymanSKU:13752- 1 eaAvailable on backorder
Immunogen: Peptide from the C-terminal region of human NF-κB (p65) • Host: Mouse • Species Reactivity: (+) Human, Mouse, Rat • Cross Reactivity: None listed • Applications: FC, IHC, WB
Brand:CaymanSKU:13752- 1 ea
NF-κB p65 is a ubiquitously expressed transcription factor that is a subunit of the NF-κB complex and is encoded by the RELA gene in humans.{53059} It is composed of an N-terminal Rel homology domain, which contains the nuclear localization signal (NLS), and mediates dimerization, nuclear localization, and DNA and protein interactions, and two C-terminal transactivation domains that are subject to a variety of post-translational modifications and regulate the transcriptional activity of p65.{53059,53060} NF-κB p65 regulates the expression of a large number of genes in response to inflammatory and environmental cues that play critical roles in innate and adaptive immunity and cellular differentiation.{53060} Silencing of Rela induces tumor cell apoptosis in a murine Lewis lung carcinoma model, and RELA silencing in THP-1 monocytes decreases secreted levels of IL-1β and TNF-α induced by LPS.{53061,53062} Genome-wide deletion of Rela in mice is embryonic lethal.{5321} NF-κB p65 is overexpressed in the inflamed joints of patients with rheumatoid arthritis, and naïve CD4 T cells isolated from the whole blood of patients with multiple sclerosis have increased phosphorylation of NF-κB p65.{53065,53066} Cayman’s NF-κB (p65) NLS Polyclonal Antibody can be used for immunocytochemistry (ICC), immunofluorescence (IF), immunohistochemistry (IHC), IHC-paraffin (IHC-P), and Western blot (WB) applications. The antibody recognizes the NLS region of NF-κB to detect NF-κB at 65 kDa from human samples. It also recognizes the NLS region of NF-κB from chimpanzee, cow, gorilla, horse, monkey, and mouse samples.
Brand:CaymanSKU:13751 - 1 eaAvailable on backorder
Immunogen: Peptide from the NF-κB (p65) NLS • Host: Rabbit • Species Reactivity: (+) Human, chimpanzee, cow, gorilla, horse, monkey, mouse • Applications: ICC, IF, IHC, IHC-P, WB
Brand:CaymanSKU:13751- 1 eaAvailable on backorder
Immunogen: Peptide from the NF-κB (p65) NLS • Host: Rabbit • Species Reactivity: (+) Human, chimpanzee, cow, gorilla, horse, monkey, mouse • Applications: ICC, IF, IHC, IHC-P, WB
Brand:CaymanSKU:13751- 1 ea
Immunogen: Synthetic peptide from the C-terminal region of human NF-κB (p65) • Host: Rabbit • Species Reactivity: (+) Human • Applications: ELISA and WB • MW = 65 kDa
Brand:CaymanSKU:20671- 100 µgAvailable on backorder
Immunogen: Synthetic peptide from the C-terminal region of human NF-κB (p65) • Host: Rabbit • Species Reactivity: (+) Human • Applications: ELISA and WB • MW = 65 kDa
Brand:CaymanSKU:20671- 100 µg NF-κB p65 is a ubiquitously expressed transcription factor that is a subunit of the NF-κB complex and is encoded by the RELA gene in humans.{53059} It is composed of an N-terminal Rel homology domain, which mediates dimerization, nuclear localization, and DNA and protein interactions, and two C-terminal transactivation domains that are subject to a variety of post-translational modifications and regulate the transcriptional activity of p65.{53059,53060} NF-κB p65 regulates the expression of a large number of genes in response to inflammatory and environmental cues that play critical roles in innate and adaptive immunity and cellular differentiation.{53060} Genome-wide deletion of Rela in mice is embryonic lethal.{5321} Silencing of NF-κB p65 induces tumor cell apoptosis in a murine Lewis lung carcinoma model and decreases secreted levels of IL-1β and TNF-α induced by LPS in THP-1 monocytes.{53061,53062} NF-κB p65 is overexpressed in inflamed joints of patients with rheumatoid arthritis, and naïve CD4 T cells isolated from the whole blood of patients with multiple sclerosis have increased phosphorylation of NF-κB p65.{53065,53066} Cayman’s NF-κB p65 (human, recombinant) protein can be used for Western blot and ELISA applications. Cayman’s NF-κB (p65) Polyclonal Antibody can be used for ELISA and Western blot applications. The antibody recognizes NF-κB at 65 kDa from human samples.
Brand:CaymanSKU:20671 - 100 µgAvailable on backorder
NF-κB p65 is a ubiquitously expressed transcription factor that is a subunit of the NF-κB complex and is encoded by the RELA gene in humans.{53059} It is composed of an N-terminal Rel homology domain, which contains the nuclear localization signal (NLS), and mediates dimerization, nuclear localization, and DNA and protein interactions, and two C-terminal transactivation domains that are subject to a variety of post-translational modifications and regulate the transcriptional activity of p65.{53059,53060} NF-κB p65 regulates the expression of a large number of genes in response to inflammatory and environmental cues that play critical roles in innate and adaptive immunity and cellular differentiation.{53060} Silencing of Rela induces tumor cell apoptosis in a murine Lewis lung carcinoma model, and RELA silencing in THP-1 monocytes decreases secreted levels of IL-1β and TNF-α induced by LPS.{53061,53062} Genome-wide deletion of Rela in mice is embryonic lethal.{5321} NF-κB p65 is overexpressed in the inflamed joints of patients with rheumatoid arthritis, and naïve CD4 T cells isolated from the whole blood of patients with multiple sclerosis have increased phosphorylation of NF-κB p65.{53065,53066} Cayman’s NF-ĸB (p65) Polyclonal Antibody (aa 2-17) can be used for Western blot (WB) applications. The antibody recognizes amino acids 2-17 of NF-κB (p65) at 60 kDa from human, chimpanzee, and monkey samples.
Brand:CaymanSKU:13757 - 1 eaAvailable on backorder
Immunogen: Synthetic peptide from the N-terminal region of human NF-κB (p65) • Host: Rabbit • Species Reactivity: (+) Human, chimpanzee, monkey • Applications: WB • MW = 60 kDa
Brand:CaymanSKU:13757- 1 eaAvailable on backorder
Immunogen: Synthetic peptide from the N-terminal region of human NF-κB (p65) • Host: Rabbit • Species Reactivity: (+) Human, chimpanzee, monkey • Applications: WB • MW = 60 kDa
Brand:CaymanSKU:13757- 1 ea
NF-κB p65 is a ubiquitously expressed transcription factor that is a subunit of the NF-κB complex and is encoded by the RELA gene in humans.{53059} It is composed of an N-terminal Rel homology domain, which contains the nuclear localization signal (NLS), and mediates dimerization, nuclear localization, and DNA and protein interactions, and two C-terminal transactivation domains that are subject to a variety of post-translational modifications and regulate the transcriptional activity of p65.{53059,53060} NF-κB p65 regulates the expression of a large number of genes in response to inflammatory and environmental cues that play critical roles in innate and adaptive immunity and cellular differentiation.{53060} Silencing of Rela induces tumor cell apoptosis in a murine Lewis lung carcinoma model, and RELA silencing in THP-1 monocytes decreases secreted levels of IL-1β and TNF-α induced by LPS.{53061,53062} Genome-wide deletion of Rela in mice is embryonic lethal.{5321} NF-κB p65 is overexpressed in the inflamed joints of patients with rheumatoid arthritis, and naïve CD4 T cells isolated from the whole blood of patients with multiple sclerosis have increased phosphorylation of NF-κB p65.{53065,53066} Cayman’s NF-κB (p65) Rabbit Monoclonal Antibody (Clone RM273) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.
Brand:CaymanSKU:32223 - 100 µlAvailable on backorder
Immunogen: Peptide from the C-terminal region of NF-κB (p65) • Host: Rabbit • Species Reactivity: (+) Human • Cross Reactivity: (+) NF-κB (p65) • Applications: IHC, WB
Brand:CaymanSKU:32223- 100 µlAvailable on backorder
Immunogen: Peptide from the C-terminal region of NF-κB (p65) • Host: Rabbit • Species Reactivity: (+) Human • Cross Reactivity: (+) NF-κB (p65) • Applications: IHC, WB
Brand:CaymanSKU:32223- 100 µl
Cayman’s NF-κB (p65) Transcription Factor Assay is a non-radioactive, sensitive method for detecting specific transcription factor DNA binding activity in nuclear extracts and whole cell lysates. A 96-well enzyme-linked immunosorbent assay (ELISA) replaces the cumbersome radioactive electrophoretic mobility shift assay (EMSA). A specific double stranded DNA (dsDNA) sequence containing the NF-κB response element is immobilized to the wells of a 96-well plate. NF-κB contained in a nuclear extract, binds specifically to the NF-κB response element. NF-κB (p65) is detected by addition of specific primary antibody directed against NF-κB (p65). A secondary antibody conjugated to HRP is added to provide a sensitive colorimetric readout at 450 nm. Cayman’s NF-κB (p65) Transcription Factor Assay detects human NF-κB (p65). It will not cross-react with NF-κB (p50).
Brand:CaymanSKU:10007889 - 96 wellsAvailable on backorder
Matrix metalloproteinase-9 (MMP-9), via activation by TNF-α, plays a key role in tumor invasion and metastasis. NF-κB activation inhibitor III is a compound that inhibits TNF-α-induced MMP-9 protein expression (maximal effect at 10 µM) by blocking NF-κB activity in HT1080 human fibrosarcoma cells.{30517} It has been used to disrupt NF-κB signaling in order to study the role of syndecans in mediating extracellular matrix integrity.{30518}
Brand:CaymanSKU:-Available on backorder
Matrix metalloproteinase-9 (MMP-9), via activation by TNF-α, plays a key role in tumor invasion and metastasis. NF-κB activation inhibitor III is a compound that inhibits TNF-α-induced MMP-9 protein expression (maximal effect at 10 µM) by blocking NF-κB activity in HT1080 human fibrosarcoma cells.{30517} It has been used to disrupt NF-κB signaling in order to study the role of syndecans in mediating extracellular matrix integrity.{30518}
Brand:CaymanSKU:-Available on backorder
NF-κB inhibitor (Item No. 17493) is a synthetic peptide corresponding to the nuclear localization sequence (NLS) of NF-κB p105 subunit (also known as p50) appended to a hydrophobic sequence to facilitate import into living cells.{17866} It blocks the nuclear import of p105 in cells treated with activators of NF-κB signaling, including LPS and TNF-α.{17866} NF-κB control is a peptide that is identical in sequence to NF-κB inhibitor, except two essential, basic residues of the p105 NLS are substituted with non-basic amino acids.{17866} It is ineffective at blocking the activation of NF-κB signaling and is used as a negative control peptide.{17866,28515,28513}
Brand:CaymanSKU:-Available on backorder
NF-κB inhibitor (Item No. 17493) is a synthetic peptide corresponding to the nuclear localization sequence (NLS) of NF-κB p105 subunit (also known as p50) appended to a hydrophobic sequence to facilitate import into living cells.{17866} It blocks the nuclear import of p105 in cells treated with activators of NF-κB signaling, including LPS and TNF-α.{17866} NF-κB control is a peptide that is identical in sequence to NF-κB inhibitor, except two essential, basic residues of the p105 NLS are substituted with non-basic amino acids.{17866} It is ineffective at blocking the activation of NF-κB signaling and is used as a negative control peptide.{17866,28515,28513}
Brand:CaymanSKU:-Available on backorder
NF-κB inhibitor (Item No. 17493) is a synthetic peptide corresponding to the nuclear localization sequence (NLS) of NF-κB p105 subunit (also known as p50) appended to a hydrophobic sequence to facilitate import into living cells.{17866} It blocks the nuclear import of p105 in cells treated with activators of NF-κB signaling, including LPS and TNF-α.{17866} NF-κB control is a peptide that is identical in sequence to NF-κB inhibitor, except two essential, basic residues of the p105 NLS are substituted with non-basic amino acids.{17866} It is ineffective at blocking the activation of NF-κB signaling and is used as a negative control peptide.{17866,28515,28513}
Brand:CaymanSKU:-Available on backorder
NF-κB inhibitor is a synthetic peptide corresponding to the nuclear localization sequence of NF-κB p105 subunit (also known as p50) appended to a hydrophobic sequence to facilitate import into living cells.{17866} It blocks the nuclear import of p105 in cells treated with activators of NF-κB signaling, including LPS and TNF-α.{17866} In this way, NF-κB inhibitor blocks gene expression that is regulated by NF-κB.{28516,28514} This peptide is commonly used to evaluate the role of NF-κB signaling in cellular responses.{28518,28517}
Brand:CaymanSKU:-Available on backorder
NF-κB inhibitor is a synthetic peptide corresponding to the nuclear localization sequence of NF-κB p105 subunit (also known as p50) appended to a hydrophobic sequence to facilitate import into living cells.{17866} It blocks the nuclear import of p105 in cells treated with activators of NF-κB signaling, including LPS and TNF-α.{17866} In this way, NF-κB inhibitor blocks gene expression that is regulated by NF-κB.{28516,28514} This peptide is commonly used to evaluate the role of NF-κB signaling in cellular responses.{28518,28517}
Brand:CaymanSKU:-Available on backorder
NF-κB inhibitor is a synthetic peptide corresponding to the nuclear localization sequence of NF-κB p105 subunit (also known as p50) appended to a hydrophobic sequence to facilitate import into living cells.{17866} It blocks the nuclear import of p105 in cells treated with activators of NF-κB signaling, including LPS and TNF-α.{17866} In this way, NF-κB inhibitor blocks gene expression that is regulated by NF-κB.{28516,28514} This peptide is commonly used to evaluate the role of NF-κB signaling in cellular responses.{28518,28517}
Brand:CaymanSKU:-Available on backorder
NF449 is an analog of suramin that selectively inhibits P2X1 purinergic receptors (pIC50 = 6.3) with a potency 19-fold greater than at P2X3, P2Y1, P2Y2, or P2Y11.{23042,23041} Through selective inhibition of the P2X1 receptor, 10 mg/kg NF449 has been used to decrease intravascular platelet aggregation in a mouse model of systemic thromboembolism.{23040} NF449 has also demonstrated selective antagonism of the Gsα-subunit G protein, which suppresses the association rate of GTPγS binding to Gsα-s, inhibits the stimulation of adenylyl cyclase activity, and blocks G protein coupling to certain GPCRs.{23039}
Brand:CaymanSKU:- NF449 is an analog of suramin that selectively inhibits P2X1 purinergic receptors (pIC50 = 6.3) with a potency 19-fold greater than at P2X3, P2Y1, P2Y2, or P2Y11.{23042,23041} Through selective inhibition of the P2X1 receptor, 10 mg/kg NF449 has been used to decrease intravascular platelet aggregation in a mouse model of systemic thromboembolism.{23040} NF449 has also demonstrated selective antagonism of the Gsα-subunit G protein, which suppresses the association rate of GTPγS binding to Gsα-s, inhibits the stimulation of adenylyl cyclase activity, and blocks G protein coupling to certain GPCRs.{23039}
Brand:CaymanSKU:- NF449 is an analog of suramin that selectively inhibits P2X1 purinergic receptors (pIC50 = 6.3) with a potency 19-fold greater than at P2X3, P2Y1, P2Y2, or P2Y11.{23042,23041} Through selective inhibition of the P2X1 receptor, 10 mg/kg NF449 has been used to decrease intravascular platelet aggregation in a mouse model of systemic thromboembolism.{23040} NF449 has also demonstrated selective antagonism of the Gsα-subunit G protein, which suppresses the association rate of GTPγS binding to Gsα-s, inhibits the stimulation of adenylyl cyclase activity, and blocks G protein coupling to certain GPCRs.{23039}
Brand:CaymanSKU:- NF449 is an analog of suramin that selectively inhibits P2X1 purinergic receptors (pIC50 = 6.3) with a potency 19-fold greater than at P2X3, P2Y1, P2Y2, or P2Y11.{23042,23041} Through selective inhibition of the P2X1 receptor, 10 mg/kg NF449 has been used to decrease intravascular platelet aggregation in a mouse model of systemic thromboembolism.{23040} NF449 has also demonstrated selective antagonism of the Gsα-subunit G protein, which suppresses the association rate of GTPγS binding to Gsα-s, inhibits the stimulation of adenylyl cyclase activity, and blocks G protein coupling to certain GPCRs.{23039}
Brand:CaymanSKU:-
NFAT activation inhibitor III is a cell-permeant inhibitor of signaling through nuclear factor of activated T cells (NFAT).{21639} It binds the substrate recognition site of the phosphatase calcineurin (Kd = 0.8 µM), preventing it from binding and dephosphorylating NFAT.{21639} NFAT activation inhibitor III blocks the nuclear import of NFAT in T cells stimulated with ionomycin (Item No. 10004974). It prevents the induced expression of cytokine mRNAs in T cells stimulated with phorbol ester and ionomycin.{21639}
Brand:CaymanSKU:21812 -Out of stock
NFAT activation inhibitor III is a cell-permeant inhibitor of signaling through nuclear factor of activated T cells (NFAT).{21639} It binds the substrate recognition site of the phosphatase calcineurin (Kd = 0.8 µM), preventing it from binding and dephosphorylating NFAT.{21639} NFAT activation inhibitor III blocks the nuclear import of NFAT in T cells stimulated with ionomycin (Item No. 10004974). It prevents the induced expression of cytokine mRNAs in T cells stimulated with phorbol ester and ionomycin.{21639}
Brand:CaymanSKU:21812 -Out of stock
NFAT activation inhibitor III is a cell-permeant inhibitor of signaling through nuclear factor of activated T cells (NFAT).{21639} It binds the substrate recognition site of the phosphatase calcineurin (Kd = 0.8 µM), preventing it from binding and dephosphorylating NFAT.{21639} NFAT activation inhibitor III blocks the nuclear import of NFAT in T cells stimulated with ionomycin (Item No. 10004974). It prevents the induced expression of cytokine mRNAs in T cells stimulated with phorbol ester and ionomycin.{21639}
Brand:CaymanSKU:21812 -Out of stock
NFAT activation inhibitor III is a cell-permeant inhibitor of signaling through nuclear factor of activated T cells (NFAT).{21639} It binds the substrate recognition site of the phosphatase calcineurin (Kd = 0.8 µM), preventing it from binding and dephosphorylating NFAT.{21639} NFAT activation inhibitor III blocks the nuclear import of NFAT in T cells stimulated with ionomycin (Item No. 10004974). It prevents the induced expression of cytokine mRNAs in T cells stimulated with phorbol ester and ionomycin.{21639}
Brand:CaymanSKU:21812 -Out of stock
The nuclear factor of activated T cells (NFAT) is a member of the REL family of transcription factors that is involved in regulating transcription of proinflammatory genes, including IL-2 and TNF-α. Calcineurin-mediated dephosphorylation promotes translocation of NFAT proteins into the nucleus, where they bind specific elements within target gene promoters, in many cases through association with other transcription factors such as AP-1, NFκB, MEF-2, and PPARγ. Molecules that interfere with this signaling pathway have potential to be effective in regulating immunosuppressive and anti-inflammatory responses. NFAT inhibitor is a cell-permeable compound that selectively inhibits calcineurin-mediated dephosphorylation of NFAT.{21639,21640,7199} At 100 μM, this inhibitor effectively blocks calcineurin binding to NFAT without disrupting other calcineurin-dependent pathways, unlike the immunosuppressants cyclosporin A and FK506 (Item No. 10007965) which indiscriminately block all calcineurin phosphatase activity.{21639,7199} NFAT inhibitor can disrupt NFAT-dependent expression of IL-2 and TNF-α when transfected in Jurak T cells and can prevent the activation and proliferation of T cells both in vitro (~ 43% at 1 µM using mixed lymphocyte cultures) and in vivo (10 mg/kg using C3H/HeN mice).{7199}
Brand:CaymanSKU:- The nuclear factor of activated T cells (NFAT) is a member of the REL family of transcription factors that is involved in regulating transcription of proinflammatory genes, including IL-2 and TNF-α. Calcineurin-mediated dephosphorylation promotes translocation of NFAT proteins into the nucleus, where they bind specific elements within target gene promoters, in many cases through association with other transcription factors such as AP-1, NFκB, MEF-2, and PPARγ. Molecules that interfere with this signaling pathway have potential to be effective in regulating immunosuppressive and anti-inflammatory responses. NFAT inhibitor is a cell-permeable compound that selectively inhibits calcineurin-mediated dephosphorylation of NFAT.{21639,21640,7199} At 100 μM, this inhibitor effectively blocks calcineurin binding to NFAT without disrupting other calcineurin-dependent pathways, unlike the immunosuppressants cyclosporin A and FK506 (Item No. 10007965) which indiscriminately block all calcineurin phosphatase activity.{21639,7199} NFAT inhibitor can disrupt NFAT-dependent expression of IL-2 and TNF-α when transfected in Jurak T cells and can prevent the activation and proliferation of T cells both in vitro (~ 43% at 1 µM using mixed lymphocyte cultures) and in vivo (10 mg/kg using C3H/HeN mice).{7199}
Brand:CaymanSKU:- The nuclear factor of activated T cells (NFAT) is a member of the REL family of transcription factors that is involved in regulating transcription of proinflammatory genes, including IL-2 and TNF-α. Calcineurin-mediated dephosphorylation promotes translocation of NFAT proteins into the nucleus, where they bind specific elements within target gene promoters, in many cases through association with other transcription factors such as AP-1, NFκB, MEF-2, and PPARγ. Molecules that interfere with this signaling pathway have potential to be effective in regulating immunosuppressive and anti-inflammatory responses. NFAT inhibitor is a cell-permeable compound that selectively inhibits calcineurin-mediated dephosphorylation of NFAT.{21639,21640,7199} At 100 μM, this inhibitor effectively blocks calcineurin binding to NFAT without disrupting other calcineurin-dependent pathways, unlike the immunosuppressants cyclosporin A and FK506 (Item No. 10007965) which indiscriminately block all calcineurin phosphatase activity.{21639,7199} NFAT inhibitor can disrupt NFAT-dependent expression of IL-2 and TNF-α when transfected in Jurak T cells and can prevent the activation and proliferation of T cells both in vitro (~ 43% at 1 µM using mixed lymphocyte cultures) and in vivo (10 mg/kg using C3H/HeN mice).{7199}
Brand:CaymanSKU:-
NFF-3 is a fluorogenic substrate of matrix metalloproteinases (MMPs).{37000} NFF-3 is hydrolyzed rapidly by MMP-3 (kcat/Km = 218,000 s-1*M-1) and slowly by MMP-9 (kcat/Km = 10,100 s-1*M-1) with no significant hydrolysis by MMP-1 or MMP-2.{37000} NFF-3 can be used to differentiate MMP-3 activity from that of other MMPs.{37000, 37001}
Brand:CaymanSKU:22188 -Out of stock
NFF-3 is a fluorogenic substrate of matrix metalloproteinases (MMPs).{37000} NFF-3 is hydrolyzed rapidly by MMP-3 (kcat/Km = 218,000 s-1*M-1) and slowly by MMP-9 (kcat/Km = 10,100 s-1*M-1) with no significant hydrolysis by MMP-1 or MMP-2.{37000} NFF-3 can be used to differentiate MMP-3 activity from that of other MMPs.{37000, 37001}
Brand:CaymanSKU:22188 -Out of stock
NG 012 is a fungal metabolite originally isolated from P. verruculosum that has fungicidal and nerve growth factor-potentiating properties.{45185,45186} It inhibits the growth of the plant pathogenic fungi B. cinerea, P. teres, P. lingam, S. sclerotiorum, and M. fructigena in vitro.{45185} NG 012 (50 μM) increases the efficacy of the antifungal miconazole (Item No. 15420) against C. albicans, reducing the IC50 value from 19.2 to 2.5 μM.{45187} It also potentiates neurite outgrowth induced by nerve growth factor (NGF) in PC12 cells in a concentration-dependent manner.{45186}
Brand:CaymanSKU:27509 - 1 mgAvailable on backorder
NG 012 is a fungal metabolite originally isolated from P. verruculosum that has fungicidal and nerve growth factor-potentiating properties.{45185,45186} It inhibits the growth of the plant pathogenic fungi B. cinerea, P. teres, P. lingam, S. sclerotiorum, and M. fructigena in vitro.{45185} NG 012 (50 μM) increases the efficacy of the antifungal miconazole (Item No. 15420) against C. albicans, reducing the IC50 value from 19.2 to 2.5 μM.{45187} It also potentiates neurite outgrowth induced by nerve growth factor (NGF) in PC12 cells in a concentration-dependent manner.{45186}
Brand:CaymanSKU:27509 - 5 mgAvailable on backorder
NG 012 is a fungal metabolite originally isolated from P. verruculosum that has fungicidal and nerve growth factor-potentiating properties.{45185,45186} It inhibits the growth of the plant pathogenic fungi B. cinerea, P. teres, P. lingam, S. sclerotiorum, and M. fructigena in vitro.{45185} NG 012 (50 μM) increases the efficacy of the antifungal miconazole (Item No. 15420) against C. albicans, reducing the IC50 value from 19.2 to 2.5 μM.{45187} It also potentiates neurite outgrowth induced by nerve growth factor (NGF) in PC12 cells in a concentration-dependent manner.{45186}
Brand:CaymanSKU:27509 - 500 µgAvailable on backorder
NG 52 is a tri-substituted purine that binds to the ATP-binding site of yeast cyclin-dependent kinases, inhibiting Cdc28p and Pho85p (IC50s = 7 and 2 µM, respectively).{6960} It is ineffective against the yeast kinases Kin28p, Srb10, and Cak1p. NG 52 is cell permeable and inhibits the growth of S. cerevisiae (GI50 = 30 µM).{6960} It is an analog of purvalanol A (Item No. 14579), a potent inhibitor of mammalian cyclin-dependent kinases.{6960}
Brand:CaymanSKU:-Available on backorder
NG 52 is a tri-substituted purine that binds to the ATP-binding site of yeast cyclin-dependent kinases, inhibiting Cdc28p and Pho85p (IC50s = 7 and 2 µM, respectively).{6960} It is ineffective against the yeast kinases Kin28p, Srb10, and Cak1p. NG 52 is cell permeable and inhibits the growth of S. cerevisiae (GI50 = 30 µM).{6960} It is an analog of purvalanol A (Item No. 14579), a potent inhibitor of mammalian cyclin-dependent kinases.{6960}
Brand:CaymanSKU:-Available on backorder
NG 52 is a tri-substituted purine that binds to the ATP-binding site of yeast cyclin-dependent kinases, inhibiting Cdc28p and Pho85p (IC50s = 7 and 2 µM, respectively).{6960} It is ineffective against the yeast kinases Kin28p, Srb10, and Cak1p. NG 52 is cell permeable and inhibits the growth of S. cerevisiae (GI50 = 30 µM).{6960} It is an analog of purvalanol A (Item No. 14579), a potent inhibitor of mammalian cyclin-dependent kinases.{6960}
Brand:CaymanSKU:-Available on backorder
NG 52 is a tri-substituted purine that binds to the ATP-binding site of yeast cyclin-dependent kinases, inhibiting Cdc28p and Pho85p (IC50s = 7 and 2 µM, respectively).{6960} It is ineffective against the yeast kinases Kin28p, Srb10, and Cak1p. NG 52 is cell permeable and inhibits the growth of S. cerevisiae (GI50 = 30 µM).{6960} It is an analog of purvalanol A (Item No. 14579), a potent inhibitor of mammalian cyclin-dependent kinases.{6960}
Brand:CaymanSKU:-Available on backorder
NG-amino-L-Arginine inhibits nNOS, iNOS, and eNOS with Ki values of 0.3, 3, and 2.5 μM, respectively.{18431,18432} Inhibition is mediated by covalent alteration of the heme prosthetic group leading to inactivation of the enzyme.{18431,18432,18434} NG-amino-L-Arginine can be used both in cell culture and in vivo.{18433,18430}
Brand:CaymanSKU:10554 - 10 mgAvailable on backorder
NG-amino-L-Arginine inhibits nNOS, iNOS, and eNOS with Ki values of 0.3, 3, and 2.5 μM, respectively.{18431,18432} Inhibition is mediated by covalent alteration of the heme prosthetic group leading to inactivation of the enzyme.{18431,18432,18434} NG-amino-L-Arginine can be used both in cell culture and in vivo.{18433,18430}
Brand:CaymanSKU:10554 - 25 mgAvailable on backorder
NG-amino-L-Arginine inhibits nNOS, iNOS, and eNOS with Ki values of 0.3, 3, and 2.5 μM, respectively.{18431,18432} Inhibition is mediated by covalent alteration of the heme prosthetic group leading to inactivation of the enzyme.{18431,18432,18434} NG-amino-L-Arginine can be used both in cell culture and in vivo.{18433,18430}
Brand:CaymanSKU:10554 - 5 mgAvailable on backorder
NG-amino-L-Arginine inhibits nNOS, iNOS, and eNOS with Ki values of 0.3, 3, and 2.5 μM, respectively.{18431,18432} Inhibition is mediated by covalent alteration of the heme prosthetic group leading to inactivation of the enzyme.{18431,18432,18434} NG-amino-L-Arginine can be used both in cell culture and in vivo.{18433,18430}
Brand:CaymanSKU:10554 - 50 mgAvailable on backorder
NG,NG-dimethyl-L-Arginine (ADMA) is an endogenous nitric oxide synthase inhibitor. ADMA concentrations increase in several disease states including renal failure, muscular dystrophy, hypercholesterolemia, and pregnancy with preeclampsia, but its precise role in these diseases has not been elucidated.{822,4517,3249,6637}
Brand:CaymanSKU:80230 - 10 mgAvailable on backorder
NG,NG-dimethyl-L-Arginine (ADMA) is an endogenous nitric oxide synthase inhibitor. ADMA concentrations increase in several disease states including renal failure, muscular dystrophy, hypercholesterolemia, and pregnancy with preeclampsia, but its precise role in these diseases has not been elucidated.{822,4517,3249,6637}
Brand:CaymanSKU:80230 - 25 mgAvailable on backorder