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Necroptosis is a regulated caspase-independent cell death mechanism that results in morphological features resembling necrosis. Serine/threonine kinase activity of the death domain receptor-associated molecule RIP1 is thought to be essential for Fas ligand–induced and tumor necrosis factor-α (TNF-α) induced necrosis.{20737} Necrostatin-7 (Nec-7) is a necroptosis inhibitor that is structurally and biologically distinct from necrostatin-1, -3, -4, and -5 as it does not inhibit RIP1 kinase. Nec-7 may target an additional regulatory molecule in this pathway as it inhibits TNF-α-induced necroptosis in a FADD-deficient variant of human Jurkat T cells with an EC50 value of 10.6 μM.{20735}
Brand:CaymanSKU:10528 - 25 mgAvailable on backorder
Necroptosis is a regulated caspase-independent cell death mechanism that results in morphological features resembling necrosis. Serine/threonine kinase activity of the death domain receptor-associated molecule RIP1 is thought to be essential for Fas ligand–induced and tumor necrosis factor-α (TNF-α) induced necrosis.{20737} Necrostatin-7 (Nec-7) is a necroptosis inhibitor that is structurally and biologically distinct from necrostatin-1, -3, -4, and -5 as it does not inhibit RIP1 kinase. Nec-7 may target an additional regulatory molecule in this pathway as it inhibits TNF-α-induced necroptosis in a FADD-deficient variant of human Jurkat T cells with an EC50 value of 10.6 μM.{20735}
Brand:CaymanSKU:10528 - 5 mgAvailable on backorder
Necrosulfonamide is a small molecule that inhibits necroptosis by blocking mixed lineage kinase domain-like protein (MLKL), a key substrate of receptor-interacting serine-threonine kinase 3 (RIP3).{33061} Necrosulfonamide has been shown to prevent the MLKL-RIP1-RIP3 necrosome complex from interacting with downstream necrosis effectors.{33061}
Brand:CaymanSKU:20844 -Out of stock
Necrosulfonamide is a small molecule that inhibits necroptosis by blocking mixed lineage kinase domain-like protein (MLKL), a key substrate of receptor-interacting serine-threonine kinase 3 (RIP3).{33061} Necrosulfonamide has been shown to prevent the MLKL-RIP1-RIP3 necrosome complex from interacting with downstream necrosis effectors.{33061}
Brand:CaymanSKU:20844 -Out of stock
Necrosulfonamide is a small molecule that inhibits necroptosis by blocking mixed lineage kinase domain-like protein (MLKL), a key substrate of receptor-interacting serine-threonine kinase 3 (RIP3).{33061} Necrosulfonamide has been shown to prevent the MLKL-RIP1-RIP3 necrosome complex from interacting with downstream necrosis effectors.{33061}
Brand:CaymanSKU:20844 -Out of stock
Necrosulfonamide is a small molecule that inhibits necroptosis by blocking mixed lineage kinase domain-like protein (MLKL), a key substrate of receptor-interacting serine-threonine kinase 3 (RIP3).{33061} Necrosulfonamide has been shown to prevent the MLKL-RIP1-RIP3 necrosome complex from interacting with downstream necrosis effectors.{33061}
Brand:CaymanSKU:20844 -Out of stock
Necrox-5 is a cell permeable inhibitor of necrosis that also demonstrates strong mitochondrial reactive oxygen species and ONOO- scavenging activity.{29191} It predominantly localizes in mitochondria, selectively blocking oxidative stress-induced necrotic cell death (0.1 μM necrox-5 inhibits ~50% cell death in H9C2 cells exposed to 400 μM t-BHP).{29191} This compound has been shown to protect cells from oxidative stress, hypoxia, and cold shock in vitro, as well as carbon tetrachloride-induced liver injury and chronic liver fibrosis in rodent models.{29191}
Brand:CaymanSKU:-Available on backorder
Necrox-5 is a cell permeable inhibitor of necrosis that also demonstrates strong mitochondrial reactive oxygen species and ONOO- scavenging activity.{29191} It predominantly localizes in mitochondria, selectively blocking oxidative stress-induced necrotic cell death (0.1 μM necrox-5 inhibits ~50% cell death in H9C2 cells exposed to 400 μM t-BHP).{29191} This compound has been shown to protect cells from oxidative stress, hypoxia, and cold shock in vitro, as well as carbon tetrachloride-induced liver injury and chronic liver fibrosis in rodent models.{29191}
Brand:CaymanSKU:-Available on backorder
Necrox-5 is a cell permeable inhibitor of necrosis that also demonstrates strong mitochondrial reactive oxygen species and ONOO- scavenging activity.{29191} It predominantly localizes in mitochondria, selectively blocking oxidative stress-induced necrotic cell death (0.1 μM necrox-5 inhibits ~50% cell death in H9C2 cells exposed to 400 μM t-BHP).{29191} This compound has been shown to protect cells from oxidative stress, hypoxia, and cold shock in vitro, as well as carbon tetrachloride-induced liver injury and chronic liver fibrosis in rodent models.{29191}
Brand:CaymanSKU:-Available on backorder
Necrox-5 is a cell permeable inhibitor of necrosis that also demonstrates strong mitochondrial reactive oxygen species and ONOO- scavenging activity.{29191} It predominantly localizes in mitochondria, selectively blocking oxidative stress-induced necrotic cell death (0.1 μM necrox-5 inhibits ~50% cell death in H9C2 cells exposed to 400 μM t-BHP).{29191} This compound has been shown to protect cells from oxidative stress, hypoxia, and cold shock in vitro, as well as carbon tetrachloride-induced liver injury and chronic liver fibrosis in rodent models.{29191}
Brand:CaymanSKU:-Available on backorder
Nedaplatin is a derivative of cisplatin (Item No. 13119) with anticancer activity.{48686} Nedaplatin undergoes spontaneous hydrolysis to form platinum complexes that cross-link DNA resulting in apoptosis and cell death.{48683,48684} It inhibits the growth of human NUGC-4 gastric and KSE-1 esophageal squamous carcinoma cells (IC50s = 4.6 and 3.4 μM, respectively) and inhibits S to G2 and G2/M to G1 cell cycle progression.{48685} Nedaplatin (44 mg/kg) decreases tumor volume and increases survival in a Lewis lung carcinoma syngeneic mouse model.{48686} Nedaplatin (40 mg/kg) also decreases tumor volume in an HNC-3 head and neck cancer mouse xenograft model.{48687} It exhibits reduced nephrotoxicity in rats compared with cisplatin.{48684}
Brand:CaymanSKU:29001 - 100 mgAvailable on backorder
Nedaplatin is a derivative of cisplatin (Item No. 13119) with anticancer activity.{48686} Nedaplatin undergoes spontaneous hydrolysis to form platinum complexes that cross-link DNA resulting in apoptosis and cell death.{48683,48684} It inhibits the growth of human NUGC-4 gastric and KSE-1 esophageal squamous carcinoma cells (IC50s = 4.6 and 3.4 μM, respectively) and inhibits S to G2 and G2/M to G1 cell cycle progression.{48685} Nedaplatin (44 mg/kg) decreases tumor volume and increases survival in a Lewis lung carcinoma syngeneic mouse model.{48686} Nedaplatin (40 mg/kg) also decreases tumor volume in an HNC-3 head and neck cancer mouse xenograft model.{48687} It exhibits reduced nephrotoxicity in rats compared with cisplatin.{48684}
Brand:CaymanSKU:29001 - 25 mgAvailable on backorder
Nedaplatin is a derivative of cisplatin (Item No. 13119) with anticancer activity.{48686} Nedaplatin undergoes spontaneous hydrolysis to form platinum complexes that cross-link DNA resulting in apoptosis and cell death.{48683,48684} It inhibits the growth of human NUGC-4 gastric and KSE-1 esophageal squamous carcinoma cells (IC50s = 4.6 and 3.4 μM, respectively) and inhibits S to G2 and G2/M to G1 cell cycle progression.{48685} Nedaplatin (44 mg/kg) decreases tumor volume and increases survival in a Lewis lung carcinoma syngeneic mouse model.{48686} Nedaplatin (40 mg/kg) also decreases tumor volume in an HNC-3 head and neck cancer mouse xenograft model.{48687} It exhibits reduced nephrotoxicity in rats compared with cisplatin.{48684}
Brand:CaymanSKU:29001 - 250 mgAvailable on backorder
Nedaplatin is a derivative of cisplatin (Item No. 13119) with anticancer activity.{48686} Nedaplatin undergoes spontaneous hydrolysis to form platinum complexes that cross-link DNA resulting in apoptosis and cell death.{48683,48684} It inhibits the growth of human NUGC-4 gastric and KSE-1 esophageal squamous carcinoma cells (IC50s = 4.6 and 3.4 μM, respectively) and inhibits S to G2 and G2/M to G1 cell cycle progression.{48685} Nedaplatin (44 mg/kg) decreases tumor volume and increases survival in a Lewis lung carcinoma syngeneic mouse model.{48686} Nedaplatin (40 mg/kg) also decreases tumor volume in an HNC-3 head and neck cancer mouse xenograft model.{48687} It exhibits reduced nephrotoxicity in rats compared with cisplatin.{48684}
Brand:CaymanSKU:29001 - 50 mgAvailable on backorder
Nedocromil is a mast cell stabilizer.{42511} It inhibits IgE-induced histamine release from rat peritoneal mast cells cocultured with 3T3 cells (MC/3T3) and preincubated with IL-2 when used at a concentration of 10 µM in acute (1 hour) and chronic (5 days) assays. Nedocromil prevents early- and late-phase bronchoconstriction in a guinea pig model of asthma induced by ovalbumin.{42512} It also prevents conjunctival edema and erythema and reduces mast cell degranulation in a rat model of conjunctivitis when administered intravenously at a dose of 2 mg/kg.{42513} Formulations containing nedocromil have been used in the treatment of allergic conjunctivitis and asthma.
Brand:CaymanSKU:24005 - 10 mgAvailable on backorder
Nedocromil is a mast cell stabilizer.{42511} It inhibits IgE-induced histamine release from rat peritoneal mast cells cocultured with 3T3 cells (MC/3T3) and preincubated with IL-2 when used at a concentration of 10 µM in acute (1 hour) and chronic (5 days) assays. Nedocromil prevents early- and late-phase bronchoconstriction in a guinea pig model of asthma induced by ovalbumin.{42512} It also prevents conjunctival edema and erythema and reduces mast cell degranulation in a rat model of conjunctivitis when administered intravenously at a dose of 2 mg/kg.{42513} Formulations containing nedocromil have been used in the treatment of allergic conjunctivitis and asthma.
Brand:CaymanSKU:24005 - 25 mgAvailable on backorder
Nedocromil is a mast cell stabilizer.{42511} It inhibits IgE-induced histamine release from rat peritoneal mast cells cocultured with 3T3 cells (MC/3T3) and preincubated with IL-2 when used at a concentration of 10 µM in acute (1 hour) and chronic (5 days) assays. Nedocromil prevents early- and late-phase bronchoconstriction in a guinea pig model of asthma induced by ovalbumin.{42512} It also prevents conjunctival edema and erythema and reduces mast cell degranulation in a rat model of conjunctivitis when administered intravenously at a dose of 2 mg/kg.{42513} Formulations containing nedocromil have been used in the treatment of allergic conjunctivitis and asthma.
Brand:CaymanSKU:24005 - 5 mgAvailable on backorder
Nedocromil is a mast cell stabilizer.{42511} It inhibits IgE-induced histamine release from rat peritoneal mast cells cocultured with 3T3 cells (MC/3T3) and preincubated with IL-2 when used at a concentration of 10 µM in acute (1 hour) and chronic (5 days) assays. Nedocromil prevents early- and late-phase bronchoconstriction in a guinea pig model of asthma induced by ovalbumin.{42512} It also prevents conjunctival edema and erythema and reduces mast cell degranulation in a rat model of conjunctivitis when administered intravenously at a dose of 2 mg/kg.{42513} Formulations containing nedocromil have been used in the treatment of allergic conjunctivitis and asthma.
Brand:CaymanSKU:24005 - 50 mgAvailable on backorder
Nefazodone is an antagonist of monoamine transporters and receptors in the CNS (Kds = 26, 48, and 80 nM for 5-HT2A, α2-adrenergic, and D2 receptors, respectively).{22877,25803,32156} It has shown efficacy as an antidepressant, reducing anxiety and agitation symptoms, in clinical trials.{31639,32156}
Brand:CaymanSKU:10012642 - 1 gAvailable on backorder
Nefazodone is an antagonist of monoamine transporters and receptors in the CNS (Kds = 26, 48, and 80 nM for 5-HT2A, α2-adrenergic, and D2 receptors, respectively).{22877,25803,32156} It has shown efficacy as an antidepressant, reducing anxiety and agitation symptoms, in clinical trials.{31639,32156}
Brand:CaymanSKU:10012642 - 250 mgAvailable on backorder
Nefazodone is an antagonist of monoamine transporters and receptors in the CNS (Kds = 26, 48, and 80 nM for 5-HT2A, α2-adrenergic, and D2 receptors, respectively).{22877,25803,32156} It has shown efficacy as an antidepressant, reducing anxiety and agitation symptoms, in clinical trials.{31639,32156}
Brand:CaymanSKU:10012642 - 500 mgAvailable on backorder
Nefiracetam (Item No. 31339) is an analytical reference standard categorized as a nootropic.{59017,59018} This product is intended for research and forensic applications.
Brand:CaymanSKU:31339 - 1 mgAvailable on backorder
Nefiracetam (Item No. 31339) is an analytical reference standard categorized as a nootropic.{59017,59018} This product is intended for research and forensic applications.
Brand:CaymanSKU:31339 - 5 mgAvailable on backorder
Nelarabine is a purine nucleoside analog that is used as a cytotoxic agent in hematological malignancies.{23725} Nelarabine is converted into arabinosyl-guanine (ara-G) in the blood, and ara-G is selectively accumulated in T cells and malignant T-lymphoid cells, where it is phosphorylated to produce ara-GTP and incorporated into DNA.{32257,32256} This leads to DNA breaks, increased expression of Fas ligand, and apoptosis.{23725,32256} Ara-G is accumulated most effectively by acute lymphoid leukemia and chronic myeloid leukemia blasts.{23725}
Brand:CaymanSKU:20248 -Available on backorder
Nelarabine is a purine nucleoside analog that is used as a cytotoxic agent in hematological malignancies.{23725} Nelarabine is converted into arabinosyl-guanine (ara-G) in the blood, and ara-G is selectively accumulated in T cells and malignant T-lymphoid cells, where it is phosphorylated to produce ara-GTP and incorporated into DNA.{32257,32256} This leads to DNA breaks, increased expression of Fas ligand, and apoptosis.{23725,32256} Ara-G is accumulated most effectively by acute lymphoid leukemia and chronic myeloid leukemia blasts.{23725}
Brand:CaymanSKU:20248 -Available on backorder
Nelarabine is a purine nucleoside analog that is used as a cytotoxic agent in hematological malignancies.{23725} Nelarabine is converted into arabinosyl-guanine (ara-G) in the blood, and ara-G is selectively accumulated in T cells and malignant T-lymphoid cells, where it is phosphorylated to produce ara-GTP and incorporated into DNA.{32257,32256} This leads to DNA breaks, increased expression of Fas ligand, and apoptosis.{23725,32256} Ara-G is accumulated most effectively by acute lymphoid leukemia and chronic myeloid leukemia blasts.{23725}
Brand:CaymanSKU:20248 -Available on backorder
Nelarabine is a purine nucleoside analog that is used as a cytotoxic agent in hematological malignancies.{23725} Nelarabine is converted into arabinosyl-guanine (ara-G) in the blood, and ara-G is selectively accumulated in T cells and malignant T-lymphoid cells, where it is phosphorylated to produce ara-GTP and incorporated into DNA.{32257,32256} This leads to DNA breaks, increased expression of Fas ligand, and apoptosis.{23725,32256} Ara-G is accumulated most effectively by acute lymphoid leukemia and chronic myeloid leukemia blasts.{23725}
Brand:CaymanSKU:20248 -Available on backorder
Nelfinavir is an orally bioavailable inhibitor of the HIV-1 protease (Ki =2 nM).{24362} It demonstrates anti-cancer activity, selectively preventing the growth of HER2-positive breast cancer cells in vitro by inhibiting Hsp90 (IC50 = 3.1 μM).{24361} Formulations containing nelfinavir have been used in combination with HIV reverse transcriptase inhibitors for the treatment of HIV infection.
Brand:CaymanSKU:- Nelfinavir is an orally bioavailable inhibitor of the HIV-1 protease (Ki =2 nM).{24362} It demonstrates anti-cancer activity, selectively preventing the growth of HER2-positive breast cancer cells in vitro by inhibiting Hsp90 (IC50 = 3.1 μM).{24361} Formulations containing nelfinavir have been used in combination with HIV reverse transcriptase inhibitors for the treatment of HIV infection.
Brand:CaymanSKU:- Nelfinavir is an orally bioavailable inhibitor of the HIV-1 protease (Ki =2 nM).{24362} It demonstrates anti-cancer activity, selectively preventing the growth of HER2-positive breast cancer cells in vitro by inhibiting Hsp90 (IC50 = 3.1 μM).{24361} Formulations containing nelfinavir have been used in combination with HIV reverse transcriptase inhibitors for the treatment of HIV infection.
Brand:CaymanSKU:- Nelfinavir is an orally bioavailable inhibitor of the HIV-1 protease (Ki =2 nM).{24362} It demonstrates anti-cancer activity, selectively preventing the growth of HER2-positive breast cancer cells in vitro by inhibiting Hsp90 (IC50 = 3.1 μM).{24361} Formulations containing nelfinavir have been used in combination with HIV reverse transcriptase inhibitors for the treatment of HIV infection.
Brand:CaymanSKU:-
Nelfinavir-d3 is intended for use as an internal standard for the quantification of nelfinavir (Item No. 15144) by GC- or LC-MS. Nelfinavir is an orally bioavailable inhibitor of the HIV-1 protease (Ki =2 nM).{24362} It demonstrates anticancer activity, selectively preventing the growth of HER2-positive breast cancer cells in vitro by inhibiting Hsp90 (IC50 = 3.1 μM).{24361} Formulations containing nelfinavir have been used in combination with HIV reverse transcriptase inhibitors for the treatment of HIV infection.
Brand:CaymanSKU:29416 - 1 mgAvailable on backorder
Nemadectin is a macrocyclic lactone antibiotic that demonstrates endectocidal and nematocidal activity.{28378} Differing only by the unsaturated side-chain extending from the 6,6-spiroketal core, this antibiotic is structurally similar to milbemycins and avermectins.{28377} Nemadectin has been used as starting material for the production of the veterinary anthelmintic, moxidectin, and its derivatives have been explored for their potential antiparasitic use.{28379,28380}
Brand:CaymanSKU:-Available on backorder
Nemadectin is a macrocyclic lactone antibiotic that demonstrates endectocidal and nematocidal activity.{28378} Differing only by the unsaturated side-chain extending from the 6,6-spiroketal core, this antibiotic is structurally similar to milbemycins and avermectins.{28377} Nemadectin has been used as starting material for the production of the veterinary anthelmintic, moxidectin, and its derivatives have been explored for their potential antiparasitic use.{28379,28380}
Brand:CaymanSKU:-Available on backorder
Nemadipine A is an L-type calcium channel blocker that induces morphological and growth defects in wild-type C. elegans and those with hypoexpression of egl-19, which encodes the only L-type calcium channel α1-subunit in the C. elegans genome.{38802} It also inhibits L-type calcium channels in chick ciliary neurons. Nemadipine A increases TRAIL-induced cytotoxicity and synergistically enhances caspase-8 and caspase-3 activation in a concentration-dependent manner in H1299 lung adenocarcinoma cells.{38803} It also decreases Survivin expression when used alone or in combination with TRAIL in A549 cells.
Brand:CaymanSKU:21689 -Out of stock
Nemadipine A is an L-type calcium channel blocker that induces morphological and growth defects in wild-type C. elegans and those with hypoexpression of egl-19, which encodes the only L-type calcium channel α1-subunit in the C. elegans genome.{38802} It also inhibits L-type calcium channels in chick ciliary neurons. Nemadipine A increases TRAIL-induced cytotoxicity and synergistically enhances caspase-8 and caspase-3 activation in a concentration-dependent manner in H1299 lung adenocarcinoma cells.{38803} It also decreases Survivin expression when used alone or in combination with TRAIL in A549 cells.
Brand:CaymanSKU:21689 -Out of stock
Nemadipine A is an L-type calcium channel blocker that induces morphological and growth defects in wild-type C. elegans and those with hypoexpression of egl-19, which encodes the only L-type calcium channel α1-subunit in the C. elegans genome.{38802} It also inhibits L-type calcium channels in chick ciliary neurons. Nemadipine A increases TRAIL-induced cytotoxicity and synergistically enhances caspase-8 and caspase-3 activation in a concentration-dependent manner in H1299 lung adenocarcinoma cells.{38803} It also decreases Survivin expression when used alone or in combination with TRAIL in A549 cells.
Brand:CaymanSKU:21689 -Out of stock
Nemadipine A is an L-type calcium channel blocker that induces morphological and growth defects in wild-type C. elegans and those with hypoexpression of egl-19, which encodes the only L-type calcium channel α1-subunit in the C. elegans genome.{38802} It also inhibits L-type calcium channels in chick ciliary neurons. Nemadipine A increases TRAIL-induced cytotoxicity and synergistically enhances caspase-8 and caspase-3 activation in a concentration-dependent manner in H1299 lung adenocarcinoma cells.{38803} It also decreases Survivin expression when used alone or in combination with TRAIL in A549 cells.
Brand:CaymanSKU:21689 -Out of stock
Nemonapride is an antipsychotic that readily passes through the blood brain barrier and exhibits potent neuroleptic effects in animals.{34046} It binds dopamine 2 (D2)-like receptors preferentially over D1-like receptors (Kis = 0.06, 0.3, and 0.15 nM for D2, D3, and D4, respectively).{34046,32473} Nemonapride also binds sigma 1 (σ1) and σ2 receptors (Kis = 8.4 and 9.6 nM, respectively) and activates the serotonin 1A receptor (5-HT1A; IC50 = 34 nM).{34047,34045}
Brand:CaymanSKU:21376 -Out of stock
Nemonapride is an antipsychotic that readily passes through the blood brain barrier and exhibits potent neuroleptic effects in animals.{34046} It binds dopamine 2 (D2)-like receptors preferentially over D1-like receptors (Kis = 0.06, 0.3, and 0.15 nM for D2, D3, and D4, respectively).{34046,32473} Nemonapride also binds sigma 1 (σ1) and σ2 receptors (Kis = 8.4 and 9.6 nM, respectively) and activates the serotonin 1A receptor (5-HT1A; IC50 = 34 nM).{34047,34045}
Brand:CaymanSKU:21376 -Out of stock
Nemonapride is an antipsychotic that readily passes through the blood brain barrier and exhibits potent neuroleptic effects in animals.{34046} It binds dopamine 2 (D2)-like receptors preferentially over D1-like receptors (Kis = 0.06, 0.3, and 0.15 nM for D2, D3, and D4, respectively).{34046,32473} Nemonapride also binds sigma 1 (σ1) and σ2 receptors (Kis = 8.4 and 9.6 nM, respectively) and activates the serotonin 1A receptor (5-HT1A; IC50 = 34 nM).{34047,34045}
Brand:CaymanSKU:21376 -Out of stock
Nemonapride is an antipsychotic that readily passes through the blood brain barrier and exhibits potent neuroleptic effects in animals.{34046} It binds dopamine 2 (D2)-like receptors preferentially over D1-like receptors (Kis = 0.06, 0.3, and 0.15 nM for D2, D3, and D4, respectively).{34046,32473} Nemonapride also binds sigma 1 (σ1) and σ2 receptors (Kis = 8.4 and 9.6 nM, respectively) and activates the serotonin 1A receptor (5-HT1A; IC50 = 34 nM).{34047,34045}
Brand:CaymanSKU:21376 -Out of stock
Nemorosone is a polycyclic polyprenylated acylphloroglucinol (PPAP) originally isolated from C. rosea that has antiproliferative properties.{43052} Nemorosone inhibits growth of NB69, Kelly, SK-N-AS, and LAN-1 neuroblastoma cells (IC50s = 3.1-6.3 µM), including several drug-resistant clones, but not MRC-5 human embryonic fibroblasts (IC50 = >40 µM).{43053} It increases DNA fragmentation in LAN-1 cells in a dose-dependent manner, and decreases N-Myc protein levels and phosphorylation of ERK1/2 by MEK1/2. Nemorosone also inhibits growth of Capan-1, AsPC-1, and MIA-PaCa-2 pancreatic cancer cells (IC50s = 4.5-5.0 µM following a 72-hour treatment) but not human dermal and foreskin fibroblasts (IC50s = >35 µM).{43052} It induces apoptosis, abolishes the mitochondrial membrane potential, and increases cytosolic calcium concentration in pancreatic cancer cells in a dose-dependent manner. Nemorosone activates the caspase cascade in a dose-dependent manner and inhibits cell cycle progression, increasing the proportion of cells in the G0/G1 phase, in both neuroblastoma and pancreatic cancer cells.{43052,43053} Nemorosone (50 mg/kg, i.p., per day) also reduces tumor growth in an MIA-PaCa-2 mouse xenograft model.{43054}
Brand:CaymanSKU:24256 - 1 mgAvailable on backorder
Nemorosone is a polycyclic polyprenylated acylphloroglucinol (PPAP) originally isolated from C. rosea that has antiproliferative properties.{43052} Nemorosone inhibits growth of NB69, Kelly, SK-N-AS, and LAN-1 neuroblastoma cells (IC50s = 3.1-6.3 µM), including several drug-resistant clones, but not MRC-5 human embryonic fibroblasts (IC50 = >40 µM).{43053} It increases DNA fragmentation in LAN-1 cells in a dose-dependent manner, and decreases N-Myc protein levels and phosphorylation of ERK1/2 by MEK1/2. Nemorosone also inhibits growth of Capan-1, AsPC-1, and MIA-PaCa-2 pancreatic cancer cells (IC50s = 4.5-5.0 µM following a 72-hour treatment) but not human dermal and foreskin fibroblasts (IC50s = >35 µM).{43052} It induces apoptosis, abolishes the mitochondrial membrane potential, and increases cytosolic calcium concentration in pancreatic cancer cells in a dose-dependent manner. Nemorosone activates the caspase cascade in a dose-dependent manner and inhibits cell cycle progression, increasing the proportion of cells in the G0/G1 phase, in both neuroblastoma and pancreatic cancer cells.{43052,43053} Nemorosone (50 mg/kg, i.p., per day) also reduces tumor growth in an MIA-PaCa-2 mouse xenograft model.{43054}
Brand:CaymanSKU:24256 - 10 mgAvailable on backorder
Nemorosone is a polycyclic polyprenylated acylphloroglucinol (PPAP) originally isolated from C. rosea that has antiproliferative properties.{43052} Nemorosone inhibits growth of NB69, Kelly, SK-N-AS, and LAN-1 neuroblastoma cells (IC50s = 3.1-6.3 µM), including several drug-resistant clones, but not MRC-5 human embryonic fibroblasts (IC50 = >40 µM).{43053} It increases DNA fragmentation in LAN-1 cells in a dose-dependent manner, and decreases N-Myc protein levels and phosphorylation of ERK1/2 by MEK1/2. Nemorosone also inhibits growth of Capan-1, AsPC-1, and MIA-PaCa-2 pancreatic cancer cells (IC50s = 4.5-5.0 µM following a 72-hour treatment) but not human dermal and foreskin fibroblasts (IC50s = >35 µM).{43052} It induces apoptosis, abolishes the mitochondrial membrane potential, and increases cytosolic calcium concentration in pancreatic cancer cells in a dose-dependent manner. Nemorosone activates the caspase cascade in a dose-dependent manner and inhibits cell cycle progression, increasing the proportion of cells in the G0/G1 phase, in both neuroblastoma and pancreatic cancer cells.{43052,43053} Nemorosone (50 mg/kg, i.p., per day) also reduces tumor growth in an MIA-PaCa-2 mouse xenograft model.{43054}
Brand:CaymanSKU:24256 - 5 mgAvailable on backorder
Neoandrographolide is one of the principle diterpenoids isolated from A. paniculata, a well-recognized medicinal plant in Asia. Extracts from A. paniculata have been reported to exert a wide range of therapeutic actions, including immunosuppressant, antithrombotic, anti-inflammatory, antineoplastic, anti-viral, anti-bacterial, anti-diabetic, anti-oxidative stress, antipyretic, anti-edematogenic, and anti-nociceptive activities.{21112} Neoandrographolide has been shown to inhibit LPS-induced nitric oxide production in inflammatory macrophages after oral administration to mice (25 mg/kg) or by direct addition to cultured macrophages (IC50 = 35.5 µM).{28493} At 25 µM, it can reduce VEGF-induced proliferation of human umbilical vein endothelial cells.{28494} Neoandrographolide also inhibits the pro-protein convertase furin with an IC50 value of 53.5 µM.{28495}
Brand:CaymanSKU:11742 - 1 mgAvailable on backorder
Neoandrographolide is one of the principle diterpenoids isolated from A. paniculata, a well-recognized medicinal plant in Asia. Extracts from A. paniculata have been reported to exert a wide range of therapeutic actions, including immunosuppressant, antithrombotic, anti-inflammatory, antineoplastic, anti-viral, anti-bacterial, anti-diabetic, anti-oxidative stress, antipyretic, anti-edematogenic, and anti-nociceptive activities.{21112} Neoandrographolide has been shown to inhibit LPS-induced nitric oxide production in inflammatory macrophages after oral administration to mice (25 mg/kg) or by direct addition to cultured macrophages (IC50 = 35.5 µM).{28493} At 25 µM, it can reduce VEGF-induced proliferation of human umbilical vein endothelial cells.{28494} Neoandrographolide also inhibits the pro-protein convertase furin with an IC50 value of 53.5 µM.{28495}
Brand:CaymanSKU:11742 - 10 mgAvailable on backorder
Neoandrographolide is one of the principle diterpenoids isolated from A. paniculata, a well-recognized medicinal plant in Asia. Extracts from A. paniculata have been reported to exert a wide range of therapeutic actions, including immunosuppressant, antithrombotic, anti-inflammatory, antineoplastic, anti-viral, anti-bacterial, anti-diabetic, anti-oxidative stress, antipyretic, anti-edematogenic, and anti-nociceptive activities.{21112} Neoandrographolide has been shown to inhibit LPS-induced nitric oxide production in inflammatory macrophages after oral administration to mice (25 mg/kg) or by direct addition to cultured macrophages (IC50 = 35.5 µM).{28493} At 25 µM, it can reduce VEGF-induced proliferation of human umbilical vein endothelial cells.{28494} Neoandrographolide also inhibits the pro-protein convertase furin with an IC50 value of 53.5 µM.{28495}
Brand:CaymanSKU:11742 - 5 mgAvailable on backorder
Neoantimycin is an antibiotic originally isolated from S. orinoci that has slight antifungal activity.{41260} It is structurally similar to antimycin (Item No. 19433) despite being produced by an unrelated species of Streptomyces. The biosynthetic pathway of neoantimycin has been determined and active analogs discovered.{41261,41262}
Brand:CaymanSKU:23645 - 1 mgAvailable on backorder
Neoantimycin is an antibiotic originally isolated from S. orinoci that has slight antifungal activity.{41260} It is structurally similar to antimycin (Item No. 19433) despite being produced by an unrelated species of Streptomyces. The biosynthetic pathway of neoantimycin has been determined and active analogs discovered.{41261,41262}
Brand:CaymanSKU:23645 - 500 µgAvailable on backorder
Neoaureothin is a bacterial metabolite that has been found in Streptomyces.{49162} It is an androgen receptor (AR) antagonist that inhibits binding of dihydrotestosterone (DHT) to ARs (IC50 = 13 μM) and inhibits DHT-induced expression of prostate-specific antigen in LNCaP cells (IC50 = 1.75 nM). Neoaureothin is cytotoxic to A549, HCT116, and HepG2 cells (IC50s = 34.3, 47, and 37.2 μg/ml, respectively).{49163} It also has nematocidal activity against the pine wood nematode B. xylophilus (LC50 = 0.84 μg/ml) and increases survival of P. densiflora trees inoculated with B. xylophilus.{49164}
Brand:CaymanSKU:28091 - 2.5 mgAvailable on backorder
Neoaureothin is a bacterial metabolite that has been found in Streptomyces.{49162} It is an androgen receptor (AR) antagonist that inhibits binding of dihydrotestosterone (DHT) to ARs (IC50 = 13 μM) and inhibits DHT-induced expression of prostate-specific antigen in LNCaP cells (IC50 = 1.75 nM). Neoaureothin is cytotoxic to A549, HCT116, and HepG2 cells (IC50s = 34.3, 47, and 37.2 μg/ml, respectively).{49163} It also has nematocidal activity against the pine wood nematode B. xylophilus (LC50 = 0.84 μg/ml) and increases survival of P. densiflora trees inoculated with B. xylophilus.{49164}
Brand:CaymanSKU:28091 - 500 µgAvailable on backorder
Neobavaisoflavone is a natural isoflavone that was first isolated from seeds of P. corylifolia, which are used in traditional herbal medicine to treat various skin diseases. Neobavaisoflavone has been found to have diverse effects in isolated mammalian cells, including inhibiting DNA polymerase and carboxylesterase 1 (Ki = 5.3 µM).{21166,32243} It also displays antibiotic activity against Gram-negative multidrug resistant bacteria.{32242}
Brand:CaymanSKU:19852 -Available on backorder
Neobavaisoflavone is a natural isoflavone that was first isolated from seeds of P. corylifolia, which are used in traditional herbal medicine to treat various skin diseases. Neobavaisoflavone has been found to have diverse effects in isolated mammalian cells, including inhibiting DNA polymerase and carboxylesterase 1 (Ki = 5.3 µM).{21166,32243} It also displays antibiotic activity against Gram-negative multidrug resistant bacteria.{32242}
Brand:CaymanSKU:19852 -Available on backorder
Neobavaisoflavone is a natural isoflavone that was first isolated from seeds of P. corylifolia, which are used in traditional herbal medicine to treat various skin diseases. Neobavaisoflavone has been found to have diverse effects in isolated mammalian cells, including inhibiting DNA polymerase and carboxylesterase 1 (Ki = 5.3 µM).{21166,32243} It also displays antibiotic activity against Gram-negative multidrug resistant bacteria.{32242}
Brand:CaymanSKU:19852 -Available on backorder
Neobavaisoflavone is a natural isoflavone that was first isolated from seeds of P. corylifolia, which are used in traditional herbal medicine to treat various skin diseases. Neobavaisoflavone has been found to have diverse effects in isolated mammalian cells, including inhibiting DNA polymerase and carboxylesterase 1 (Ki = 5.3 µM).{21166,32243} It also displays antibiotic activity against Gram-negative multidrug resistant bacteria.{32242}
Brand:CaymanSKU:19852 -Available on backorder
Neocuproine is a phenanthroline compound that is used as a chelating agent in a wide array of transition metal-catalyzed reactions.{32864} It can also be used in the synthesis of aryl ketones.
Brand:CaymanSKU:20874 -Out of stock
Neocuproine is a phenanthroline compound that is used as a chelating agent in a wide array of transition metal-catalyzed reactions.{32864} It can also be used in the synthesis of aryl ketones.
Brand:CaymanSKU:20874 -Out of stock
Neocuproine is a phenanthroline compound that is used as a chelating agent in a wide array of transition metal-catalyzed reactions.{32864} It can also be used in the synthesis of aryl ketones.
Brand:CaymanSKU:20874 -Out of stock
Neocuproine is a phenanthroline compound that is used as a chelating agent in a wide array of transition metal-catalyzed reactions.{32864} It can also be used in the synthesis of aryl ketones.
Brand:CaymanSKU:20874 -Out of stock
Neoeriocitrin is a flavonoid that has been found in C. paradisi and has antioxidative and osteogenic activities.{48344,48345} It inhibits the production of 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals by 17.2% and the formation of superoxide radicals by 48.3% in cell-free assays, as well as decreases the rate of LDL oxidation ex vivo in isolated hamster plasma. Neoeriocitrin (2 µg/ml) increases proliferation of MC3T3-E1 osteoblast percursor cells and reverses the antiproliferative effect of the MEK1 inhibitor PD 98059 (Item No. 10006726).{48345} It also increases the expression of the osteogenic differentiation markers Runx2, Type 1 collagen, and osteocalcin.
Brand:CaymanSKU:25839 - 1 mgAvailable on backorder
Neoeriocitrin is a flavonoid that has been found in C. paradisi and has antioxidative and osteogenic activities.{48344,48345} It inhibits the production of 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals by 17.2% and the formation of superoxide radicals by 48.3% in cell-free assays, as well as decreases the rate of LDL oxidation ex vivo in isolated hamster plasma. Neoeriocitrin (2 µg/ml) increases proliferation of MC3T3-E1 osteoblast percursor cells and reverses the antiproliferative effect of the MEK1 inhibitor PD 98059 (Item No. 10006726).{48345} It also increases the expression of the osteogenic differentiation markers Runx2, Type 1 collagen, and osteocalcin.
Brand:CaymanSKU:25839 - 10 mgAvailable on backorder
Neoeriocitrin is a flavonoid that has been found in C. paradisi and has antioxidative and osteogenic activities.{48344,48345} It inhibits the production of 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals by 17.2% and the formation of superoxide radicals by 48.3% in cell-free assays, as well as decreases the rate of LDL oxidation ex vivo in isolated hamster plasma. Neoeriocitrin (2 µg/ml) increases proliferation of MC3T3-E1 osteoblast percursor cells and reverses the antiproliferative effect of the MEK1 inhibitor PD 98059 (Item No. 10006726).{48345} It also increases the expression of the osteogenic differentiation markers Runx2, Type 1 collagen, and osteocalcin.
Brand:CaymanSKU:25839 - 25 mgAvailable on backorder
Neoeriocitrin is a flavonoid that has been found in C. paradisi and has antioxidative and osteogenic activities.{48344,48345} It inhibits the production of 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals by 17.2% and the formation of superoxide radicals by 48.3% in cell-free assays, as well as decreases the rate of LDL oxidation ex vivo in isolated hamster plasma. Neoeriocitrin (2 µg/ml) increases proliferation of MC3T3-E1 osteoblast percursor cells and reverses the antiproliferative effect of the MEK1 inhibitor PD 98059 (Item No. 10006726).{48345} It also increases the expression of the osteogenic differentiation markers Runx2, Type 1 collagen, and osteocalcin.
Brand:CaymanSKU:25839 - 5 mgAvailable on backorder
Neohesperidin is a flavonoid found in citrus fruit peel that has diverse biological activities.{39203,39204,39205} In vitro, it inhibits osteoclast differentiation, bone resorption, calcium oscillations, and activation of NF-κB and nuclear factor of activated T cells (NFAT) by receptor activator of NF-κB ligand (RANKL).{39203} In vivo, neohesperidin administration protects ovariectomized mice from bone loss. Neohesperidin acts as a hypolipidemic agent, reducing lipid accumulation in HepG2 cells and reversing hyperlipidemia in a mouse model of diet-induced obesity.{39204} In a mouse model of diabetes, neohesperidin increases glucose tolerance and decreases insulin resistance while simultaneously decreasing serum triglycerides and total cholesterol and inhibiting lipid accumulation in livers in vivo.{39205}
Brand:CaymanSKU:23028 - 100 mgAvailable on backorder
Neohesperidin is a flavonoid found in citrus fruit peel that has diverse biological activities.{39203,39204,39205} In vitro, it inhibits osteoclast differentiation, bone resorption, calcium oscillations, and activation of NF-κB and nuclear factor of activated T cells (NFAT) by receptor activator of NF-κB ligand (RANKL).{39203} In vivo, neohesperidin administration protects ovariectomized mice from bone loss. Neohesperidin acts as a hypolipidemic agent, reducing lipid accumulation in HepG2 cells and reversing hyperlipidemia in a mouse model of diet-induced obesity.{39204} In a mouse model of diabetes, neohesperidin increases glucose tolerance and decreases insulin resistance while simultaneously decreasing serum triglycerides and total cholesterol and inhibiting lipid accumulation in livers in vivo.{39205}
Brand:CaymanSKU:23028 - 250 mgAvailable on backorder
Neohesperidin is a flavonoid found in citrus fruit peel that has diverse biological activities.{39203,39204,39205} In vitro, it inhibits osteoclast differentiation, bone resorption, calcium oscillations, and activation of NF-κB and nuclear factor of activated T cells (NFAT) by receptor activator of NF-κB ligand (RANKL).{39203} In vivo, neohesperidin administration protects ovariectomized mice from bone loss. Neohesperidin acts as a hypolipidemic agent, reducing lipid accumulation in HepG2 cells and reversing hyperlipidemia in a mouse model of diet-induced obesity.{39204} In a mouse model of diabetes, neohesperidin increases glucose tolerance and decreases insulin resistance while simultaneously decreasing serum triglycerides and total cholesterol and inhibiting lipid accumulation in livers in vivo.{39205}
Brand:CaymanSKU:23028 - 500 mgAvailable on backorder
Neohesperidin dihydrochalcone (NHDC) is a semisynthetic glycoside chalcone, an artificial sweetener, and a derivative of neohesperidin (Item No. 23028).{46476,46477} It scavenges 59.9, 66.7, 6.3, and 20% of 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805), ABTS (Item No. 27317), superoxide, and hydroxyl radicals, respectively, in cell-free assays when used at a concentration of 50 μM.{46478} NHDC (200 mg/kg per day) inhibits decreases in hepatic GSH levels and increases in serum aspartate aminotransferase (AST) and alanine transaminase (ALT) activity and hepatic levels of reactive oxygen species (ROS), thiobarbituric acid reactive substances (TBARS), NF-κB, IL-6, IL-1β, and TNF-α in a mouse model of acute liver injury induced by paraquat.{46477}
Brand:CaymanSKU:28510 - 1 gAvailable on backorder
Neohesperidin dihydrochalcone (NHDC) is a semisynthetic glycoside chalcone, an artificial sweetener, and a derivative of neohesperidin (Item No. 23028).{46476,46477} It scavenges 59.9, 66.7, 6.3, and 20% of 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805), ABTS (Item No. 27317), superoxide, and hydroxyl radicals, respectively, in cell-free assays when used at a concentration of 50 μM.{46478} NHDC (200 mg/kg per day) inhibits decreases in hepatic GSH levels and increases in serum aspartate aminotransferase (AST) and alanine transaminase (ALT) activity and hepatic levels of reactive oxygen species (ROS), thiobarbituric acid reactive substances (TBARS), NF-κB, IL-6, IL-1β, and TNF-α in a mouse model of acute liver injury induced by paraquat.{46477}
Brand:CaymanSKU:28510 - 10 gAvailable on backorder
Neohesperidin dihydrochalcone (NHDC) is a semisynthetic glycoside chalcone, an artificial sweetener, and a derivative of neohesperidin (Item No. 23028).{46476,46477} It scavenges 59.9, 66.7, 6.3, and 20% of 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805), ABTS (Item No. 27317), superoxide, and hydroxyl radicals, respectively, in cell-free assays when used at a concentration of 50 μM.{46478} NHDC (200 mg/kg per day) inhibits decreases in hepatic GSH levels and increases in serum aspartate aminotransferase (AST) and alanine transaminase (ALT) activity and hepatic levels of reactive oxygen species (ROS), thiobarbituric acid reactive substances (TBARS), NF-κB, IL-6, IL-1β, and TNF-α in a mouse model of acute liver injury induced by paraquat.{46477}
Brand:CaymanSKU:28510 - 25 gAvailable on backorder
Neohesperidin dihydrochalcone (NHDC) is a semisynthetic glycoside chalcone, an artificial sweetener, and a derivative of neohesperidin (Item No. 23028).{46476,46477} It scavenges 59.9, 66.7, 6.3, and 20% of 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805), ABTS (Item No. 27317), superoxide, and hydroxyl radicals, respectively, in cell-free assays when used at a concentration of 50 μM.{46478} NHDC (200 mg/kg per day) inhibits decreases in hepatic GSH levels and increases in serum aspartate aminotransferase (AST) and alanine transaminase (ALT) activity and hepatic levels of reactive oxygen species (ROS), thiobarbituric acid reactive substances (TBARS), NF-κB, IL-6, IL-1β, and TNF-α in a mouse model of acute liver injury induced by paraquat.{46477}
Brand:CaymanSKU:28510 - 5 gAvailable on backorder
Neohydroxyaspergillic acid is a fungal metabolite produced by A. sclerotiorum that has antibiotic and antifungal activities.{41711} It inhibits the growth of P. aeruginosa, M. smegmatis, S. aureus, E. coli, K. pneumoniae, B. mycoides, and B. subtilis bacteria (MICs = 125-500 μg/ml). Neohydroxyaspergillic acid also inhibits the growth of G. convolute, S. consortiale, P. blakesleeanus, C. globosum, and T. mentagrophytes (MICs = 175-700 μg/ml) but not A. niger, P. notatum, M. verrucaria, or S. cerevisiae fungi.
Brand:CaymanSKU:24918 - 1 mgAvailable on backorder
Neohydroxyaspergillic acid is a fungal metabolite produced by A. sclerotiorum that has antibiotic and antifungal activities.{41711} It inhibits the growth of P. aeruginosa, M. smegmatis, S. aureus, E. coli, K. pneumoniae, B. mycoides, and B. subtilis bacteria (MICs = 125-500 μg/ml). Neohydroxyaspergillic acid also inhibits the growth of G. convolute, S. consortiale, P. blakesleeanus, C. globosum, and T. mentagrophytes (MICs = 175-700 μg/ml) but not A. niger, P. notatum, M. verrucaria, or S. cerevisiae fungi.
Brand:CaymanSKU:24918 - 5 mgAvailable on backorder
Neomycin is an aminoglycoside antibiotic produced by S. fradiae that inhibits protein translation by binding to the small subunit of prokaryotic ribosomes.{22680} It blocks voltage-sensitive Ca2+ channels and is a potent inhibitor of skeletal muscle sarcoplasmic reticulum Ca2+ release.{22682} Neomycin has been shown to inhibit inositol phospholipid turnover, phospholipase C, and phosphatidylcholine-phospholipase D activity (IC50 = 65 µM).{22681} It is highly effective against Gram-positive and Gram-negative bacteria and is commonly used for the prevention of bacterial contamination of cell cultures.
Brand:CaymanSKU:- Neomycin is an aminoglycoside antibiotic produced by S. fradiae that inhibits protein translation by binding to the small subunit of prokaryotic ribosomes.{22680} It blocks voltage-sensitive Ca2+ channels and is a potent inhibitor of skeletal muscle sarcoplasmic reticulum Ca2+ release.{22682} Neomycin has been shown to inhibit inositol phospholipid turnover, phospholipase C, and phosphatidylcholine-phospholipase D activity (IC50 = 65 µM).{22681} It is highly effective against Gram-positive and Gram-negative bacteria and is commonly used for the prevention of bacterial contamination of cell cultures.
Brand:CaymanSKU:-
Neoruscogenin is a natural sapogenin isolated from Butcher’s broom (R. rhizoma), which is traditionally used against chronic venous disorders.{26498} It is a bioavailable, potent, and high-affinity agonist of the nuclear receptor RORα (EC50 = 110 nM).{26497} In mice, neoruscogenin up-regulates the expression of several RORα-inducible genes in the liver, when given at 3 mg/kg/d orally for seven days.{26497}
Brand:CaymanSKU:- Neoruscogenin is a natural sapogenin isolated from Butcher’s broom (R. rhizoma), which is traditionally used against chronic venous disorders.{26498} It is a bioavailable, potent, and high-affinity agonist of the nuclear receptor RORα (EC50 = 110 nM).{26497} In mice, neoruscogenin up-regulates the expression of several RORα-inducible genes in the liver, when given at 3 mg/kg/d orally for seven days.{26497}
Brand:CaymanSKU:- Neoruscogenin is a natural sapogenin isolated from Butcher’s broom (R. rhizoma), which is traditionally used against chronic venous disorders.{26498} It is a bioavailable, potent, and high-affinity agonist of the nuclear receptor RORα (EC50 = 110 nM).{26497} In mice, neoruscogenin up-regulates the expression of several RORα-inducible genes in the liver, when given at 3 mg/kg/d orally for seven days.{26497}
Brand:CaymanSKU:-
Neosolaniol is a type A trichothecene mycotoxin.{31927} It is relatively less toxic than other type A trichothecenes, including T-2 toxin (Item No. 11444).{31925,31926}
Brand:CaymanSKU:11436 - 1 mgAvailable on backorder
Neosolaniol is a type A trichothecene mycotoxin.{31927} It is relatively less toxic than other type A trichothecenes, including T-2 toxin (Item No. 11444).{31925,31926}
Brand:CaymanSKU:11436 - 5 mgAvailable on backorder
Neostigmine is a reversible inhibitor of acetylcholinesterase (AChE; Kd = 260 μM).{40760} In a rat model of knee joint inflammation, intrathecal administration of neostigmine (2-30 μg) increases endogenous acetylcholine levels and dose-dependently increases the latency of paw withdrawal in response to thermal and mechanical stimuli (ED50s = 6.6 and 3.5 μg, respectively).{40761} Neostigmine (5 μg, i.p.) restores muscle action potentials in mice with a thymopoietin-induced neuromuscular block.{40762} Formulations containing neostigmine have been used in the treatment of myasthenia gravis and Ogilvie syndrome.
Brand:CaymanSKU:23501 - 1 gAvailable on backorder