Cayman
Showing 31201–31350 of 45550 results
-
N-isopropyl Hexylone (hydrochloride) (Item No. 27076) is an analytical reference standard categorized as a cathinone. This product is intended for research and forensic applications.
Brand:CaymanSKU:27076 - 1 mgAvailable on backorder
N-isopropyl Hexylone (hydrochloride) (Item No. 27076) is an analytical reference standard categorized as a cathinone. This product is intended for research and forensic applications.
Brand:CaymanSKU:27076 - 5 mgAvailable on backorder
N-Isopropylnoraptropine is used in the synthesis of ipratropium, a bronchodilator compound with nonselective muscarinic antagonist activity.{30061} It has been used to examine the stability of ipratropium.{30061}
Brand:CaymanSKU:-Available on backorder
N-Isopropylnoraptropine is used in the synthesis of ipratropium, a bronchodilator compound with nonselective muscarinic antagonist activity.{30061} It has been used to examine the stability of ipratropium.{30061}
Brand:CaymanSKU:-Available on backorder
N-Isopropylnoraptropine is used in the synthesis of ipratropium, a bronchodilator compound with nonselective muscarinic antagonist activity.{30061} It has been used to examine the stability of ipratropium.{30061}
Brand:CaymanSKU:-Available on backorder
Several different arachidonoyl amino acid conjugates, including N-arachidonoyl dopamine and N-arachidonoyl-L-serine, have been isolated and characterized from bovine brain.{9589} N-lignoceroyl taurine is one of several novel taurine-conjugated fatty acids discovered during mass spectrometry lipidomic analysis of brain and spinal cord from wild-type and fatty acid amide hydrolase (FAAH) knockout mice.{13153} The levels of N-lignoceroyl taurine were elevated 23-26 fold in FAAH-/- mice compared to wild-type mice, indicating that FAAH utilizes N-lignoceroyl taurine as a substrate. However, in vitro experiments with purified FAAH indicate N-lignoceroyl taurine is hydrolyzed 2,000 times more slowly by FAAH compared to oleoyl ethanolamide.{13153} N-acyl taurines bearing polyunsaturated acyl chains can activate members of the transient receptor potential (TRP) family of calcium channels, including TRPV1 and TRPV4.{16245}
Brand:CaymanSKU:10007286 - 1 mgAvailable on backorder
Several different arachidonoyl amino acid conjugates, including N-arachidonoyl dopamine and N-arachidonoyl-L-serine, have been isolated and characterized from bovine brain.{9589} N-lignoceroyl taurine is one of several novel taurine-conjugated fatty acids discovered during mass spectrometry lipidomic analysis of brain and spinal cord from wild-type and fatty acid amide hydrolase (FAAH) knockout mice.{13153} The levels of N-lignoceroyl taurine were elevated 23-26 fold in FAAH-/- mice compared to wild-type mice, indicating that FAAH utilizes N-lignoceroyl taurine as a substrate. However, in vitro experiments with purified FAAH indicate N-lignoceroyl taurine is hydrolyzed 2,000 times more slowly by FAAH compared to oleoyl ethanolamide.{13153} N-acyl taurines bearing polyunsaturated acyl chains can activate members of the transient receptor potential (TRP) family of calcium channels, including TRPV1 and TRPV4.{16245}
Brand:CaymanSKU:10007286 - 10 mgAvailable on backorder
Several different arachidonoyl amino acid conjugates, including N-arachidonoyl dopamine and N-arachidonoyl-L-serine, have been isolated and characterized from bovine brain.{9589} N-lignoceroyl taurine is one of several novel taurine-conjugated fatty acids discovered during mass spectrometry lipidomic analysis of brain and spinal cord from wild-type and fatty acid amide hydrolase (FAAH) knockout mice.{13153} The levels of N-lignoceroyl taurine were elevated 23-26 fold in FAAH-/- mice compared to wild-type mice, indicating that FAAH utilizes N-lignoceroyl taurine as a substrate. However, in vitro experiments with purified FAAH indicate N-lignoceroyl taurine is hydrolyzed 2,000 times more slowly by FAAH compared to oleoyl ethanolamide.{13153} N-acyl taurines bearing polyunsaturated acyl chains can activate members of the transient receptor potential (TRP) family of calcium channels, including TRPV1 and TRPV4.{16245}
Brand:CaymanSKU:10007286 - 5 mgAvailable on backorder
N-methyl Homarylamine (hydrochloride) (Item No. 22239) is an analytical reference standard categorized as a phenethylamine.{35032} This product is intended for research and forensic applications.
Brand:CaymanSKU:22239 -Out of stock
N-methyl Homarylamine (hydrochloride) (Item No. 22239) is an analytical reference standard categorized as a phenethylamine.{35032} This product is intended for research and forensic applications.
Brand:CaymanSKU:22239 -Out of stock
Produced by neutrophils, macrophages, mast cells, and by transcellular metabolism in platelets, leukotriene C4 (LTC4) is the parent cysteinyl leukotriene formed by the LTC4 synthase-catalyzed conjugation of glutathione to LTA4.{781} It is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) and exhibits potent smooth muscle contracting activity.{538} LTC4, however, is rapidly metabolized to LTD4 and LTE4, which makes the characterization of LTC4 pharmacology difficult.{1251} N-methyl Leukotriene C4 (N-methyl LTC4) is a synthetic analog of LTC4 that is not readily metabolized to LTD4 and LTE4.{16001}It acts as a potent and selective CysLT2 receptor agonist exhibiting EC50 values of 122 and > 2,000 nM at the human CysLT2 and CysLT1 receptors, respectively.{18790} It has essentially the same potency as LTC4 at both the human and murine receptors CysLT2 receptors. N-methyl LTC4 is potent and active in vivo, causing vascular leak in mice overexpressing the human CysLT2 receptor but not in CysLT2 receptor knockout mice.{18790}
Brand:CaymanSKU:- Produced by neutrophils, macrophages, mast cells, and by transcellular metabolism in platelets, leukotriene C4 (LTC4) is the parent cysteinyl leukotriene formed by the LTC4 synthase-catalyzed conjugation of glutathione to LTA4.{781} It is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) and exhibits potent smooth muscle contracting activity.{538} LTC4, however, is rapidly metabolized to LTD4 and LTE4, which makes the characterization of LTC4 pharmacology difficult.{1251} N-methyl Leukotriene C4 (N-methyl LTC4) is a synthetic analog of LTC4 that is not readily metabolized to LTD4 and LTE4.{16001}It acts as a potent and selective CysLT2 receptor agonist exhibiting EC50 values of 122 and > 2,000 nM at the human CysLT2 and CysLT1 receptors, respectively.{18790} It has essentially the same potency as LTC4 at both the human and murine receptors CysLT2 receptors. N-methyl LTC4 is potent and active in vivo, causing vascular leak in mice overexpressing the human CysLT2 receptor but not in CysLT2 receptor knockout mice.{18790}
Brand:CaymanSKU:- Produced by neutrophils, macrophages, mast cells, and by transcellular metabolism in platelets, leukotriene C4 (LTC4) is the parent cysteinyl leukotriene formed by the LTC4 synthase-catalyzed conjugation of glutathione to LTA4.{781} It is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) and exhibits potent smooth muscle contracting activity.{538} LTC4, however, is rapidly metabolized to LTD4 and LTE4, which makes the characterization of LTC4 pharmacology difficult.{1251} N-methyl Leukotriene C4 (N-methyl LTC4) is a synthetic analog of LTC4 that is not readily metabolized to LTD4 and LTE4.{16001}It acts as a potent and selective CysLT2 receptor agonist exhibiting EC50 values of 122 and > 2,000 nM at the human CysLT2 and CysLT1 receptors, respectively.{18790} It has essentially the same potency as LTC4 at both the human and murine receptors CysLT2 receptors. N-methyl LTC4 is potent and active in vivo, causing vascular leak in mice overexpressing the human CysLT2 receptor but not in CysLT2 receptor knockout mice.{18790}
Brand:CaymanSKU:-
N-methyl Mesoporphyrin IX is a transition state analog of porphyrin and an inhibitor of ferrochelatase.{48312} It inhibits ferrochelatase in mouse liver mitochondria in vitro and in vivo, leading to an accumulation of porphyrin in isolated liver mitochondria following administration of an intravenous dose of 80 nmol. N-methyl Mesoporphyrin IX has been used as a turn-on biosensor for target DNA sequences when used in complex with a G-quadruplex-forming sequence fused to a DNA sequence complementary to the target sequence.{48313} It has also been used to detect amyloid-β (1-40) (Aβ40) fibrils in vitro and in live PC12 cells overexpressing Aβ.{48314} N-methyl Mesoporphyrin displays excitation/emission maxima of 399/610 nm, respectively.{48315}
Brand:CaymanSKU:27210 - 1 mgAvailable on backorder
N-methyl Mesoporphyrin IX is a transition state analog of porphyrin and an inhibitor of ferrochelatase.{48312} It inhibits ferrochelatase in mouse liver mitochondria in vitro and in vivo, leading to an accumulation of porphyrin in isolated liver mitochondria following administration of an intravenous dose of 80 nmol. N-methyl Mesoporphyrin IX has been used as a turn-on biosensor for target DNA sequences when used in complex with a G-quadruplex-forming sequence fused to a DNA sequence complementary to the target sequence.{48313} It has also been used to detect amyloid-β (1-40) (Aβ40) fibrils in vitro and in live PC12 cells overexpressing Aβ.{48314} N-methyl Mesoporphyrin displays excitation/emission maxima of 399/610 nm, respectively.{48315}
Brand:CaymanSKU:27210 - 5 mgAvailable on backorder
N-methyl meta-methyl Phenyl fentanyl (Item No. 28076) is an analytical reference standard that is structurally similar to known opioids. This product is intended for research and forensic applications.
Brand:CaymanSKU:28076 - 1 mgAvailable on backorder
N-methyl meta-methyl Phenyl fentanyl (Item No. 28076) is an analytical reference standard that is structurally similar to known opioids. This product is intended for research and forensic applications.
Brand:CaymanSKU:28076 - 5 mgAvailable on backorder
![A derivative of paroxetine; inhibits [3H]paroxetine binding to rat cortical membranes (Ki = 4.3 nM); inhibits 5-HT uptake in rat brain synaptosomes (IC50 = 22 nM); has been used as a precursor in the synthesis of paroxetine; a potential impurity in commercial preparations of paroxetine](https://interpriseusa.com/wp-content/uploads/2021/06/26160.png)
N-methyl Paroxetine is a derivative of the selective serotonin reuptake inhibitor (SSRI) antidepressant paroxetine (Item No. 14998) that inhibits [3H]paroxetine binding to rat cortical membranes (Ki = 4.3 nM).{48143} It inhibits serotonin (5-HT; Item No. 14332) uptake in rat brain synaptosomes with an IC50 value of 22 nM.{48144} N-methyl Paroxetine has been used as a precursor in the synthesis of paroxetine and is a potential impurity in commercial preparations of paroxetine.{48145}
Brand:CaymanSKU:26160 - 1 gAvailable on backorder
N-methyl Paroxetine is a derivative of the selective serotonin reuptake inhibitor (SSRI) antidepressant paroxetine (Item No. 14998) that inhibits [3H]paroxetine binding to rat cortical membranes (Ki = 4.3 nM).{48143} It inhibits serotonin (5-HT; Item No. 14332) uptake in rat brain synaptosomes with an IC50 value of 22 nM.{48144} N-methyl Paroxetine has been used as a precursor in the synthesis of paroxetine and is a potential impurity in commercial preparations of paroxetine.{48145}
Brand:CaymanSKU:26160 - 250 mgAvailable on backorder
N-methyl Paroxetine is a derivative of the selective serotonin reuptake inhibitor (SSRI) antidepressant paroxetine (Item No. 14998) that inhibits [3H]paroxetine binding to rat cortical membranes (Ki = 4.3 nM).{48143} It inhibits serotonin (5-HT; Item No. 14332) uptake in rat brain synaptosomes with an IC50 value of 22 nM.{48144} N-methyl Paroxetine has been used as a precursor in the synthesis of paroxetine and is a potential impurity in commercial preparations of paroxetine.{48145}
Brand:CaymanSKU:26160 - 5 gAvailable on backorder
N-methyl Paroxetine is a derivative of the selective serotonin reuptake inhibitor (SSRI) antidepressant paroxetine (Item No. 14998) that inhibits [3H]paroxetine binding to rat cortical membranes (Ki = 4.3 nM).{48143} It inhibits serotonin (5-HT; Item No. 14332) uptake in rat brain synaptosomes with an IC50 value of 22 nM.{48144} N-methyl Paroxetine has been used as a precursor in the synthesis of paroxetine and is a potential impurity in commercial preparations of paroxetine.{48145}
Brand:CaymanSKU:26160 - 500 mgAvailable on backorder
N-methyl Protoporphyrin IX is a transition state analog that potently inhibits protoporphyrin IX ferrochelatase (Ki = 10 nM), blocking the terminal step of the heme biosynthetic pathway.{32587,32588} It is used to study the effect of heme synthesis blockade in cell systems.{32585,32586}
Brand:CaymanSKU:20846 -Out of stock
N-methyl Protoporphyrin IX is a transition state analog that potently inhibits protoporphyrin IX ferrochelatase (Ki = 10 nM), blocking the terminal step of the heme biosynthetic pathway.{32587,32588} It is used to study the effect of heme synthesis blockade in cell systems.{32585,32586}
Brand:CaymanSKU:20846 -Out of stock
N-methyl Protoporphyrin IX is a transition state analog that potently inhibits protoporphyrin IX ferrochelatase (Ki = 10 nM), blocking the terminal step of the heme biosynthetic pathway.{32587,32588} It is used to study the effect of heme synthesis blockade in cell systems.{32585,32586}
Brand:CaymanSKU:20846 -Out of stock
N-methyl U-47931E (Item No. 24286) is an analytical reference standard that is structurally similar to known opioids. It is an amide-methylated form of U-47931E (Item No. 20530). This product is intended for research and forensic applications.
Brand:CaymanSKU:24286 - 1 mgAvailable on backorder
N-methyl U-47931E (Item No. 24286) is an analytical reference standard that is structurally similar to known opioids. It is an amide-methylated form of U-47931E (Item No. 20530). This product is intended for research and forensic applications.
Brand:CaymanSKU:24286 - 5 mgAvailable on backorder
N-methyl-1-Phenylpropan-1-amine (hydrochloride) (Item No. 21630) is an analytical reference standard that is structurally categorized as a benzylamine. The physiological and toxicological properties of this compound are not known. This product is intended for research and forensic applications.
Brand:CaymanSKU:21630 -Out of stock
N-methyl-1-Phenylpropan-1-amine (hydrochloride) (Item No. 21630) is an analytical reference standard that is structurally categorized as a benzylamine. The physiological and toxicological properties of this compound are not known. This product is intended for research and forensic applications.
Brand:CaymanSKU:21630 -Out of stock
Aminoindanes (AIs) were originally studied as semi-rigid congeners of phenylethylamines, which are psychoactive alkaloids.{20192,20175} N-methyl-2-AI is an AI that reduces nociception and inhibits exploratory activity in mice.{20192} Its physiological and toxicological properties in humans have not been elucidated. This product is intended for forensic and research purposes.
Brand:CaymanSKU:- Aminoindanes (AIs) were originally studied as semi-rigid congeners of phenylethylamines, which are psychoactive alkaloids.{20192,20175} N-methyl-2-AI is an AI that reduces nociception and inhibits exploratory activity in mice.{20192} Its physiological and toxicological properties in humans have not been elucidated. This product is intended for forensic and research purposes.
Brand:CaymanSKU:- Aminoindanes (AIs) were originally studied as semi-rigid congeners of phenylethylamines, which are psychoactive alkaloids.{20192,20175} N-methyl-2-AI is an AI that reduces nociception and inhibits exploratory activity in mice.{20192} Its physiological and toxicological properties in humans have not been elucidated. This product is intended for forensic and research purposes.
Brand:CaymanSKU:-
N-methyl-2-HOBA is a methylated form of the isoketal scavenger 2-HOBA (Item No. 25357).{40882} It has low reactivity with isoketals and has no effect on hypertension induced by angiotensin II (Item No. 17150). N-methyl-2-HOBA has been used as a negative control for the activity of 2-HOBA in a mouse model of hypertension.
Brand:CaymanSKU:25399 - 1 gAvailable on backorder
N-methyl-2-Phenylpropan-1-amine (hydrochloride) (Item No. 18563) is an analytical reference standard that is classified as a phenethylamine.{30515} It is a positional isomer of methamphetamine that has been sold as a dietary supplement and subsequently banned by the World Anti-Doping Agency.{30513,30514} This product is intended for research and forensic applications.
Brand:CaymanSKU:-Available on backorder
N-methyl-2-Phenylpropan-1-amine (hydrochloride) (Item No. 18563) is an analytical reference standard that is classified as a phenethylamine.{30515} It is a positional isomer of methamphetamine that has been sold as a dietary supplement and subsequently banned by the World Anti-Doping Agency.{30513,30514} This product is intended for research and forensic applications.
Brand:CaymanSKU:-Available on backorder
N-methyl-2-Phenylpropan-1-amine (hydrochloride) (Item No. 18563) is an analytical reference standard that is classified as a phenethylamine.{30515} It is a positional isomer of methamphetamine that has been sold as a dietary supplement and subsequently banned by the World Anti-Doping Agency.{30513,30514} This product is intended for research and forensic applications.
Brand:CaymanSKU:-Available on backorder
N-methyl-N-Ethyltryptamine (oxalate) (Item No. 25268) is an analytical reference standard categorized as a tryptamine. This product is intended for research and forensic applications.
Brand:CaymanSKU:25268 - 1 mgAvailable on backorder
N-methyl-N-Ethyltryptamine (oxalate) (Item No. 25268) is an analytical reference standard categorized as a tryptamine. This product is intended for research and forensic applications.
Brand:CaymanSKU:25268 - 5 mgAvailable on backorder
N-Methylnicotinamide is an isomer of nicotinamide. N-methylnicotinamide (20 mg/animal) increases urinary excretion of nicotinamide, 1-methylnicotinamide (Item No. 16604), 1-methyl-2-pyridone-5-carboxamide, and 1-methyl-4-pyridone-3-carboxamide in mice in similar ratios as those excreted following nicotinamide administration.{36563} It is also found in human urine.{36564}
Brand:CaymanSKU:21850 -Out of stock
N-Methylnicotinamide is an isomer of nicotinamide. N-methylnicotinamide (20 mg/animal) increases urinary excretion of nicotinamide, 1-methylnicotinamide (Item No. 16604), 1-methyl-2-pyridone-5-carboxamide, and 1-methyl-4-pyridone-3-carboxamide in mice in similar ratios as those excreted following nicotinamide administration.{36563} It is also found in human urine.{36564}
Brand:CaymanSKU:21850 -Out of stock
N-Methylnicotinamide is an isomer of nicotinamide. N-methylnicotinamide (20 mg/animal) increases urinary excretion of nicotinamide, 1-methylnicotinamide (Item No. 16604), 1-methyl-2-pyridone-5-carboxamide, and 1-methyl-4-pyridone-3-carboxamide in mice in similar ratios as those excreted following nicotinamide administration.{36563} It is also found in human urine.{36564}
Brand:CaymanSKU:21850 -Out of stock
N-Nitroso-N-ethylaniline is a member of the N-nitrosamine class of compounds, which are classified as carcinogens by the Environmental Protection Agency.{48547} However, N-nitroso-N-ethylaniline is non-carcinogenic in a survival assay using 2FR450 Rauscher leukemia virus-infected rat embryo cultures.{48548} It is a synthetic intermediate in the synthesis of 3-amino-4-hydrazine-cyclobut-3-ene-1,2-diones as antagonists of chemokine (C-X-C motif) receptor 2 (CXCR2).{48549}
Brand:CaymanSKU:21063 -Out of stock
N-Nitroso-N-ethylaniline is a member of the N-nitrosamine class of compounds, which are classified as carcinogens by the Environmental Protection Agency.{48547} However, N-nitroso-N-ethylaniline is non-carcinogenic in a survival assay using 2FR450 Rauscher leukemia virus-infected rat embryo cultures.{48548} It is a synthetic intermediate in the synthesis of 3-amino-4-hydrazine-cyclobut-3-ene-1,2-diones as antagonists of chemokine (C-X-C motif) receptor 2 (CXCR2).{48549}
Brand:CaymanSKU:21063 -Out of stock
N-Nitroso-N-ethylaniline is a member of the N-nitrosamine class of compounds, which are classified as carcinogens by the Environmental Protection Agency.{48547} However, N-nitroso-N-ethylaniline is non-carcinogenic in a survival assay using 2FR450 Rauscher leukemia virus-infected rat embryo cultures.{48548} It is a synthetic intermediate in the synthesis of 3-amino-4-hydrazine-cyclobut-3-ene-1,2-diones as antagonists of chemokine (C-X-C motif) receptor 2 (CXCR2).{48549}
Brand:CaymanSKU:21063 -Out of stock
N-Nitroso-N-ethylaniline is a member of the N-nitrosamine class of compounds, which are classified as carcinogens by the Environmental Protection Agency.{48547} However, N-nitroso-N-ethylaniline is non-carcinogenic in a survival assay using 2FR450 Rauscher leukemia virus-infected rat embryo cultures.{48548} It is a synthetic intermediate in the synthesis of 3-amino-4-hydrazine-cyclobut-3-ene-1,2-diones as antagonists of chemokine (C-X-C motif) receptor 2 (CXCR2).{48549}
Brand:CaymanSKU:21063 -Out of stock
N-Nitroso-N-methyl-4-aminobutyric acid (NMBA) is a tobacco-specific nitrosamine carcinogen.{56171} It is oxidized to the reactive metabolite methyl-2-oxopropylnitrosamine (MOPN) in isolated rat liver mitochondria.{56172} NMBA induces bladder transitional cell carcinomas in rats when administered in the drinking water at a concentration of 300 mg/L per day.{56173}
Brand:CaymanSKU:30911 - 10 mgAvailable on backorder
N-Nitroso-N-methyl-4-aminobutyric acid (NMBA) is a tobacco-specific nitrosamine carcinogen.{56171} It is oxidized to the reactive metabolite methyl-2-oxopropylnitrosamine (MOPN) in isolated rat liver mitochondria.{56172} NMBA induces bladder transitional cell carcinomas in rats when administered in the drinking water at a concentration of 300 mg/L per day.{56173}
Brand:CaymanSKU:30911 - 100 mgAvailable on backorder
N-Nitroso-N-methyl-4-aminobutyric acid (NMBA) is a tobacco-specific nitrosamine carcinogen.{56171} It is oxidized to the reactive metabolite methyl-2-oxopropylnitrosamine (MOPN) in isolated rat liver mitochondria.{56172} NMBA induces bladder transitional cell carcinomas in rats when administered in the drinking water at a concentration of 300 mg/L per day.{56173}
Brand:CaymanSKU:30911 - 25 mgAvailable on backorder
N-Nitroso-N-methyl-4-aminobutyric acid (NMBA) is a tobacco-specific nitrosamine carcinogen.{56171} It is oxidized to the reactive metabolite methyl-2-oxopropylnitrosamine (MOPN) in isolated rat liver mitochondria.{56172} NMBA induces bladder transitional cell carcinomas in rats when administered in the drinking water at a concentration of 300 mg/L per day.{56173}
Brand:CaymanSKU:30911 - 50 mgAvailable on backorder
Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density.{15370} This regulatory process manifests itself with a variety of phenotypes including biofilm formation and virulence factor production.{13434} Coordinated gene expression is achieved by the production, release, and detection of small diffusible signal molecules called autoinducers. The N-acylated homoserine lactones (AHLs) comprise one such class of autoinducers, each of which generally consists of a fatty acid coupled with homoserine lactone (HSL). Regulation of bacterial quorum sensing signaling systems to inhibit pathogenesis represents a new approach to antimicrobial therapy in the treatment of infectious diseases.{15369} AHLs vary in acyl group length (C4-C18), in the substitution of C3 (hydrogen, hydroxyl, or oxo group), and in the presence or absence of one or more carbon-carbon double bonds in the fatty acid chain. These differences confer signal specificity through the affinity of transcriptional regulators of the LuxR family.{15398} C9-HSL is a rare odd-numbered acyl carbon chain produced by wild-type Erwinia carotovora strain SCC 3193 grown in the nutrient-rich Luria-Bertani Broth (LB) medium.{16766}
Brand:CaymanSKU:-Out of stock
Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density.{15370} This regulatory process manifests itself with a variety of phenotypes including biofilm formation and virulence factor production.{13434} Coordinated gene expression is achieved by the production, release, and detection of small diffusible signal molecules called autoinducers. The N-acylated homoserine lactones (AHLs) comprise one such class of autoinducers, each of which generally consists of a fatty acid coupled with homoserine lactone (HSL). Regulation of bacterial quorum sensing signaling systems to inhibit pathogenesis represents a new approach to antimicrobial therapy in the treatment of infectious diseases.{15369} AHLs vary in acyl group length (C4-C18), in the substitution of C3 (hydrogen, hydroxyl, or oxo group), and in the presence or absence of one or more carbon-carbon double bonds in the fatty acid chain. These differences confer signal specificity through the affinity of transcriptional regulators of the LuxR family.{15398} C9-HSL is a rare odd-numbered acyl carbon chain produced by wild-type Erwinia carotovora strain SCC 3193 grown in the nutrient-rich Luria-Bertani Broth (LB) medium.{16766}
Brand:CaymanSKU:-Out of stock
Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density.{15370} This regulatory process manifests itself with a variety of phenotypes including biofilm formation and virulence factor production.{13434} Coordinated gene expression is achieved by the production, release, and detection of small diffusible signal molecules called autoinducers. The N-acylated homoserine lactones (AHLs) comprise one such class of autoinducers, each of which generally consists of a fatty acid coupled with homoserine lactone (HSL). Regulation of bacterial quorum sensing signaling systems to inhibit pathogenesis represents a new approach to antimicrobial therapy in the treatment of infectious diseases.{15369} AHLs vary in acyl group length (C4-C18), in the substitution of C3 (hydrogen, hydroxyl, or oxo group), and in the presence or absence of one or more carbon-carbon double bonds in the fatty acid chain. These differences confer signal specificity through the affinity of transcriptional regulators of the LuxR family.{15398} C9-HSL is a rare odd-numbered acyl carbon chain produced by wild-type Erwinia carotovora strain SCC 3193 grown in the nutrient-rich Luria-Bertani Broth (LB) medium.{16766}
Brand:CaymanSKU:-Out of stock
Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density.{15370} This regulatory process manifests itself with a variety of phenotypes including biofilm formation and virulence factor production.{13434} Coordinated gene expression is achieved by the production, release, and detection of small diffusible signal molecules called autoinducers. The N-acylated homoserine lactones (AHLs) comprise one such class of autoinducers, each of which generally consists of a fatty acid coupled with homoserine lactone (HSL). Regulation of bacterial quorum sensing signaling systems to inhibit pathogenesis represents a new approach to antimicrobial therapy in the treatment of infectious diseases.{15369} AHLs vary in acyl group length (C4-C18), in the substitution of C3 (hydrogen, hydroxyl, or oxo group), and in the presence or absence of one or more carbon-carbon double bonds in the fatty acid chain. These differences confer signal specificity through the affinity of transcriptional regulators of the LuxR family.{15398} C9-HSL is a rare odd-numbered acyl carbon chain produced by wild-type Erwinia carotovora strain SCC 3193 grown in the nutrient-rich Luria-Bertani Broth (LB) medium.{16766}
Brand:CaymanSKU:-Out of stock
n-Nonyl-β-D-glucopyranoside is an anionic alkylglucoside chiral surfactant that is commonly used for the solubilization and crystallization of biological membrane proteins.{47022} It has also been used in the separation of drug enantiomers by micellar electrokinetic chromatography.{47023}
Brand:CaymanSKU:25705 - 1 gAvailable on backorder
n-Nonyl-β-D-glucopyranoside is an anionic alkylglucoside chiral surfactant that is commonly used for the solubilization and crystallization of biological membrane proteins.{47022} It has also been used in the separation of drug enantiomers by micellar electrokinetic chromatography.{47023}
Brand:CaymanSKU:25705 - 100 mgAvailable on backorder
n-Nonyl-β-D-glucopyranoside is an anionic alkylglucoside chiral surfactant that is commonly used for the solubilization and crystallization of biological membrane proteins.{47022} It has also been used in the separation of drug enantiomers by micellar electrokinetic chromatography.{47023}
Brand:CaymanSKU:25705 - 250 mgAvailable on backorder
n-Nonyl-β-D-glucopyranoside is an anionic alkylglucoside chiral surfactant that is commonly used for the solubilization and crystallization of biological membrane proteins.{47022} It has also been used in the separation of drug enantiomers by micellar electrokinetic chromatography.{47023}
Brand:CaymanSKU:25705 - 500 mgAvailable on backorder
N-Nonyldeoxynojirimycin (NN-DNJ) is an inhibitor of acid α-glucosidase and α-1,6-glucosidase (IC50s = 0.42 and 8.4 μM, respectively).{52246} NN-DNJ (250 mg/kg per day) increases hepatic glycogen levels in fasted mice and gastrocnemius muscle glycogen levels in both fasted and fed mice. It is a chemical chaperone of β-glucosidase that increases activity by 1.65-fold in patient-derived fibroblasts homozygous for the N370S Gaucher disease mutation when added to the culture medium at a concentration of 5 μM, but inhibits β-glucosidase activity at concentrations greater than 60 μM.{52247} NN-DNJ inhibits viral replication in BHK-21 cells infected with Japanese encephalitis virus (JEV) or dengue virus serotype 2 (DEN-2) and has protective effects in a mouse model of lethal JEV challenge when administered at a dose of 200 mg/kg per day.{52248}
Brand:CaymanSKU:29698 - 1 mgAvailable on backorder
N-Nonyldeoxynojirimycin (NN-DNJ) is an inhibitor of acid α-glucosidase and α-1,6-glucosidase (IC50s = 0.42 and 8.4 μM, respectively).{52246} NN-DNJ (250 mg/kg per day) increases hepatic glycogen levels in fasted mice and gastrocnemius muscle glycogen levels in both fasted and fed mice. It is a chemical chaperone of β-glucosidase that increases activity by 1.65-fold in patient-derived fibroblasts homozygous for the N370S Gaucher disease mutation when added to the culture medium at a concentration of 5 μM, but inhibits β-glucosidase activity at concentrations greater than 60 μM.{52247} NN-DNJ inhibits viral replication in BHK-21 cells infected with Japanese encephalitis virus (JEV) or dengue virus serotype 2 (DEN-2) and has protective effects in a mouse model of lethal JEV challenge when administered at a dose of 200 mg/kg per day.{52248}
Brand:CaymanSKU:29698 - 10 mgAvailable on backorder
N-Nonyldeoxynojirimycin (NN-DNJ) is an inhibitor of acid α-glucosidase and α-1,6-glucosidase (IC50s = 0.42 and 8.4 μM, respectively).{52246} NN-DNJ (250 mg/kg per day) increases hepatic glycogen levels in fasted mice and gastrocnemius muscle glycogen levels in both fasted and fed mice. It is a chemical chaperone of β-glucosidase that increases activity by 1.65-fold in patient-derived fibroblasts homozygous for the N370S Gaucher disease mutation when added to the culture medium at a concentration of 5 μM, but inhibits β-glucosidase activity at concentrations greater than 60 μM.{52247} NN-DNJ inhibits viral replication in BHK-21 cells infected with Japanese encephalitis virus (JEV) or dengue virus serotype 2 (DEN-2) and has protective effects in a mouse model of lethal JEV challenge when administered at a dose of 200 mg/kg per day.{52248}
Brand:CaymanSKU:29698 - 25 mgAvailable on backorder
N-Nonyldeoxynojirimycin (NN-DNJ) is an inhibitor of acid α-glucosidase and α-1,6-glucosidase (IC50s = 0.42 and 8.4 μM, respectively).{52246} NN-DNJ (250 mg/kg per day) increases hepatic glycogen levels in fasted mice and gastrocnemius muscle glycogen levels in both fasted and fed mice. It is a chemical chaperone of β-glucosidase that increases activity by 1.65-fold in patient-derived fibroblasts homozygous for the N370S Gaucher disease mutation when added to the culture medium at a concentration of 5 μM, but inhibits β-glucosidase activity at concentrations greater than 60 μM.{52247} NN-DNJ inhibits viral replication in BHK-21 cells infected with Japanese encephalitis virus (JEV) or dengue virus serotype 2 (DEN-2) and has protective effects in a mouse model of lethal JEV challenge when administered at a dose of 200 mg/kg per day.{52248}
Brand:CaymanSKU:29698 - 5 mgAvailable on backorder
Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density.{15370} This regulatory process manifests itself with a variety of phenotypes including biofilm formation and virulence factor production.{13434} Coordinated gene expression is achieved by the production, release, and detection of small diffusible signal molecules called autoinducers. The N-acylated homoserine lactones (AHLs) comprise one such class of autoinducers, each of which generally consists of a fatty acid coupled with homoserine lactone (HSL). Regulation of bacterial quorum sensing signaling systems to inhibit pathogenesis represents a new approach to antimicrobial therapy in the treatment of infectious diseases.{15369} AHLs vary in acyl group length (C4-C18), in the substitution of C3 (hydrogen, hydroxyl, or oxo group), and in the presence or absence of one or more carbon-carbon double bonds in the fatty acid chain. These differences confer signal specificity through the affinity of transcriptional regulators of the LuxR family.{15398} C18-HSL is one of four lipophilic, long acyl side-chain bearing AHLs produced by the LuxI AHL synthase homolog SinI involved in quorum sensing signaling in strains of S. meliloti, a nitrogen-fixing bacterial symbiont of the legume M. sativa.{15828} C18-HSL and other hydrophobic AHLs tend to localize in relatively lipophilic cellular environments of bacteria and cannot diffuse freely through the cell membrane. The long-chain N-acylhomoserine lactones may be exported from cells by efflux pumps or may be transported between communicating cells by way of extracellular outer membrane vesicles.{16892,16832}
Brand:CaymanSKU:- Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density.{15370} This regulatory process manifests itself with a variety of phenotypes including biofilm formation and virulence factor production.{13434} Coordinated gene expression is achieved by the production, release, and detection of small diffusible signal molecules called autoinducers. The N-acylated homoserine lactones (AHLs) comprise one such class of autoinducers, each of which generally consists of a fatty acid coupled with homoserine lactone (HSL). Regulation of bacterial quorum sensing signaling systems to inhibit pathogenesis represents a new approach to antimicrobial therapy in the treatment of infectious diseases.{15369} AHLs vary in acyl group length (C4-C18), in the substitution of C3 (hydrogen, hydroxyl, or oxo group), and in the presence or absence of one or more carbon-carbon double bonds in the fatty acid chain. These differences confer signal specificity through the affinity of transcriptional regulators of the LuxR family.{15398} C18-HSL is one of four lipophilic, long acyl side-chain bearing AHLs produced by the LuxI AHL synthase homolog SinI involved in quorum sensing signaling in strains of S. meliloti, a nitrogen-fixing bacterial symbiont of the legume M. sativa.{15828} C18-HSL and other hydrophobic AHLs tend to localize in relatively lipophilic cellular environments of bacteria and cannot diffuse freely through the cell membrane. The long-chain N-acylhomoserine lactones may be exported from cells by efflux pumps or may be transported between communicating cells by way of extracellular outer membrane vesicles.{16892,16832}
Brand:CaymanSKU:- Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density.{15370} This regulatory process manifests itself with a variety of phenotypes including biofilm formation and virulence factor production.{13434} Coordinated gene expression is achieved by the production, release, and detection of small diffusible signal molecules called autoinducers. The N-acylated homoserine lactones (AHLs) comprise one such class of autoinducers, each of which generally consists of a fatty acid coupled with homoserine lactone (HSL). Regulation of bacterial quorum sensing signaling systems to inhibit pathogenesis represents a new approach to antimicrobial therapy in the treatment of infectious diseases.{15369} AHLs vary in acyl group length (C4-C18), in the substitution of C3 (hydrogen, hydroxyl, or oxo group), and in the presence or absence of one or more carbon-carbon double bonds in the fatty acid chain. These differences confer signal specificity through the affinity of transcriptional regulators of the LuxR family.{15398} C18-HSL is one of four lipophilic, long acyl side-chain bearing AHLs produced by the LuxI AHL synthase homolog SinI involved in quorum sensing signaling in strains of S. meliloti, a nitrogen-fixing bacterial symbiont of the legume M. sativa.{15828} C18-HSL and other hydrophobic AHLs tend to localize in relatively lipophilic cellular environments of bacteria and cannot diffuse freely through the cell membrane. The long-chain N-acylhomoserine lactones may be exported from cells by efflux pumps or may be transported between communicating cells by way of extracellular outer membrane vesicles.{16892,16832}
Brand:CaymanSKU:- Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density.{15370} This regulatory process manifests itself with a variety of phenotypes including biofilm formation and virulence factor production.{13434} Coordinated gene expression is achieved by the production, release, and detection of small diffusible signal molecules called autoinducers. The N-acylated homoserine lactones (AHLs) comprise one such class of autoinducers, each of which generally consists of a fatty acid coupled with homoserine lactone (HSL). Regulation of bacterial quorum sensing signaling systems to inhibit pathogenesis represents a new approach to antimicrobial therapy in the treatment of infectious diseases.{15369} AHLs vary in acyl group length (C4-C18), in the substitution of C3 (hydrogen, hydroxyl, or oxo group), and in the presence or absence of one or more carbon-carbon double bonds in the fatty acid chain. These differences confer signal specificity through the affinity of transcriptional regulators of the LuxR family.{15398} C18-HSL is one of four lipophilic, long acyl side-chain bearing AHLs produced by the LuxI AHL synthase homolog SinI involved in quorum sensing signaling in strains of S. meliloti, a nitrogen-fixing bacterial symbiont of the legume M. sativa.{15828} C18-HSL and other hydrophobic AHLs tend to localize in relatively lipophilic cellular environments of bacteria and cannot diffuse freely through the cell membrane. The long-chain N-acylhomoserine lactones may be exported from cells by efflux pumps or may be transported between communicating cells by way of extracellular outer membrane vesicles.{16892,16832}
Brand:CaymanSKU:-
Peroxisome proliferator-activated receptors (PPARs) play an essential role in regulating lipid and glucose metabolism. Oleoyl ethanolamide (OEA), a natural ligand for PPARα, has been shown to suppress food intake and reduce weight gain in rats when administered systemically at 10 mg/kg intraperitoneally.{9302,11423} N-Octadecyl-N’-propyl-sulfamide is an analog of OEA with selective binding affinity for PPARα. It is a more potent activator of PPARα, exhibiting an EC50 value of 100 nM, compared to OEA, which exhibits an EC50 value of 120 nM.{14617,11423} At a dose of 1 mg/kg for 8-11 days, N-octadecyl-N’-propyl-sulfamide induces satiety, thereby decreasing food-intake, body weight, and plasma triglyceride concentration in free-feeding Wistar and obese Zucker (fa/fa) rats.{14617}
Brand:CaymanSKU:10009661 - 10 mgAvailable on backorder
Peroxisome proliferator-activated receptors (PPARs) play an essential role in regulating lipid and glucose metabolism. Oleoyl ethanolamide (OEA), a natural ligand for PPARα, has been shown to suppress food intake and reduce weight gain in rats when administered systemically at 10 mg/kg intraperitoneally.{9302,11423} N-Octadecyl-N’-propyl-sulfamide is an analog of OEA with selective binding affinity for PPARα. It is a more potent activator of PPARα, exhibiting an EC50 value of 100 nM, compared to OEA, which exhibits an EC50 value of 120 nM.{14617,11423} At a dose of 1 mg/kg for 8-11 days, N-octadecyl-N’-propyl-sulfamide induces satiety, thereby decreasing food-intake, body weight, and plasma triglyceride concentration in free-feeding Wistar and obese Zucker (fa/fa) rats.{14617}
Brand:CaymanSKU:10009661 - 25 mgAvailable on backorder
Peroxisome proliferator-activated receptors (PPARs) play an essential role in regulating lipid and glucose metabolism. Oleoyl ethanolamide (OEA), a natural ligand for PPARα, has been shown to suppress food intake and reduce weight gain in rats when administered systemically at 10 mg/kg intraperitoneally.{9302,11423} N-Octadecyl-N’-propyl-sulfamide is an analog of OEA with selective binding affinity for PPARα. It is a more potent activator of PPARα, exhibiting an EC50 value of 100 nM, compared to OEA, which exhibits an EC50 value of 120 nM.{14617,11423} At a dose of 1 mg/kg for 8-11 days, N-octadecyl-N’-propyl-sulfamide induces satiety, thereby decreasing food-intake, body weight, and plasma triglyceride concentration in free-feeding Wistar and obese Zucker (fa/fa) rats.{14617}
Brand:CaymanSKU:10009661 - 5 mgAvailable on backorder
Peroxisome proliferator-activated receptors (PPARs) play an essential role in regulating lipid and glucose metabolism. Oleoyl ethanolamide (OEA), a natural ligand for PPARα, has been shown to suppress food intake and reduce weight gain in rats when administered systemically at 10 mg/kg intraperitoneally.{9302,11423} N-Octadecyl-N’-propyl-sulfamide is an analog of OEA with selective binding affinity for PPARα. It is a more potent activator of PPARα, exhibiting an EC50 value of 100 nM, compared to OEA, which exhibits an EC50 value of 120 nM.{14617,11423} At a dose of 1 mg/kg for 8-11 days, N-octadecyl-N’-propyl-sulfamide induces satiety, thereby decreasing food-intake, body weight, and plasma triglyceride concentration in free-feeding Wistar and obese Zucker (fa/fa) rats.{14617}
Brand:CaymanSKU:10009661 - 50 mgAvailable on backorder
Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density. Controlling bacterial infections by quenching their quorum sensing systems is a promising field of study. The expression of specific target genes, such as transcriptional regulators belonging to the LuxIR family of proteins, is coordinated by synthesis of diffusible acylhomoserine lactone (AHL) molecules. N-octanoyl-L-Homoserine lactone (C8-HSL) is a small diffusible signaling molecule involved in quorum sensing, thereby controlling gene expression and affecting cellular metabolism.{16305,16307,16308} The applications of this molecule include infection prevention and regulation of virulence in general and in cystic fibrosis.{16306,15377}
Brand:CaymanSKU:10011199 - 10 mgAvailable on backorder
Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density. Controlling bacterial infections by quenching their quorum sensing systems is a promising field of study. The expression of specific target genes, such as transcriptional regulators belonging to the LuxIR family of proteins, is coordinated by synthesis of diffusible acylhomoserine lactone (AHL) molecules. N-octanoyl-L-Homoserine lactone (C8-HSL) is a small diffusible signaling molecule involved in quorum sensing, thereby controlling gene expression and affecting cellular metabolism.{16305,16307,16308} The applications of this molecule include infection prevention and regulation of virulence in general and in cystic fibrosis.{16306,15377}
Brand:CaymanSKU:10011199 - 25 mgAvailable on backorder
Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density. Controlling bacterial infections by quenching their quorum sensing systems is a promising field of study. The expression of specific target genes, such as transcriptional regulators belonging to the LuxIR family of proteins, is coordinated by synthesis of diffusible acylhomoserine lactone (AHL) molecules. N-octanoyl-L-Homoserine lactone (C8-HSL) is a small diffusible signaling molecule involved in quorum sensing, thereby controlling gene expression and affecting cellular metabolism.{16305,16307,16308} The applications of this molecule include infection prevention and regulation of virulence in general and in cystic fibrosis.{16306,15377}
Brand:CaymanSKU:10011199 - 5 mgAvailable on backorder
Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density. Controlling bacterial infections by quenching their quorum sensing systems is a promising field of study. The expression of specific target genes, such as transcriptional regulators belonging to the LuxIR family of proteins, is coordinated by synthesis of diffusible acylhomoserine lactone (AHL) molecules. N-octanoyl-L-Homoserine lactone (C8-HSL) is a small diffusible signaling molecule involved in quorum sensing, thereby controlling gene expression and affecting cellular metabolism.{16305,16307,16308} The applications of this molecule include infection prevention and regulation of virulence in general and in cystic fibrosis.{16306,15377}
Brand:CaymanSKU:10011199 - 50 mgAvailable on backorder
n-Octyl-β-D-thioglucopyranoside (OTG) is a low molecular weight nonionic detergent that is commonly used for cell lysis and non-denaturing protein solubilization.{28286,28287} It has a critical micelle concentration of 7.9-9.0 mM.{28286,28285} OTG is stable in aqueous solutions, resistant to degradation by β-glucosidases, and easily removed by dialysis.{28286,28287}
Brand:CaymanSKU:-Out of stock
n-Octyl-β-D-thioglucopyranoside (OTG) is a low molecular weight nonionic detergent that is commonly used for cell lysis and non-denaturing protein solubilization.{28286,28287} It has a critical micelle concentration of 7.9-9.0 mM.{28286,28285} OTG is stable in aqueous solutions, resistant to degradation by β-glucosidases, and easily removed by dialysis.{28286,28287}
Brand:CaymanSKU:-Out of stock
n-Octyl-β-D-thioglucopyranoside (OTG) is a low molecular weight nonionic detergent that is commonly used for cell lysis and non-denaturing protein solubilization.{28286,28287} It has a critical micelle concentration of 7.9-9.0 mM.{28286,28285} OTG is stable in aqueous solutions, resistant to degradation by β-glucosidases, and easily removed by dialysis.{28286,28287}
Brand:CaymanSKU:-Out of stock
n-Octyl-β-D-thioglucopyranoside (OTG) is a low molecular weight nonionic detergent that is commonly used for cell lysis and non-denaturing protein solubilization.{28286,28287} It has a critical micelle concentration of 7.9-9.0 mM.{28286,28285} OTG is stable in aqueous solutions, resistant to degradation by β-glucosidases, and easily removed by dialysis.{28286,28287}
Brand:CaymanSKU:-Out of stock
n-Octylglucoside is a mild, non-denaturing detergent that is used for the solubilization and reconstitution of membrane-bound proteins. The high critical micelle concentration (0.7%) of n-octylglucoside facilitates ready removal from final protein extracts by dialysis or gel filtration.{23410,23409} n-Octylglucoside can be used in 2D electrophoresis and to improve selectivity of immunoprecipitation of phosphotyrosine modified proteins.{23408,23410}
Brand:CaymanSKU:- n-Octylglucoside is a mild, non-denaturing detergent that is used for the solubilization and reconstitution of membrane-bound proteins. The high critical micelle concentration (0.7%) of n-octylglucoside facilitates ready removal from final protein extracts by dialysis or gel filtration.{23410,23409} n-Octylglucoside can be used in 2D electrophoresis and to improve selectivity of immunoprecipitation of phosphotyrosine modified proteins.{23408,23410}
Brand:CaymanSKU:- n-Octylglucoside is a mild, non-denaturing detergent that is used for the solubilization and reconstitution of membrane-bound proteins. The high critical micelle concentration (0.7%) of n-octylglucoside facilitates ready removal from final protein extracts by dialysis or gel filtration.{23410,23409} n-Octylglucoside can be used in 2D electrophoresis and to improve selectivity of immunoprecipitation of phosphotyrosine modified proteins.{23408,23410}
Brand:CaymanSKU:-
N-Oleoyl alanine is a natural N-acyl amide that has been detected in insect and animal tissues.{33754,33755} Several N-acyl amides are bioactive mediators that modulate G protein-coupled receptors or transient receptor potential channels, although the activity of N-oleoyl alanine has not been delineated.{33754,33755}
Brand:CaymanSKU:20368 -Available on backorder
N-Oleoyl alanine is a natural N-acyl amide that has been detected in insect and animal tissues.{33754,33755} Several N-acyl amides are bioactive mediators that modulate G protein-coupled receptors or transient receptor potential channels, although the activity of N-oleoyl alanine has not been delineated.{33754,33755}
Brand:CaymanSKU:20368 -Available on backorder