Cayman

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Mouse Anti-c-myc IgG:DyLight® 488 – 100 μg

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Cayman

SKU:11247- 100 μg

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Mouse Anti-c-myc IgG:DyLight® 488 – 100 μg

Mouse anti-c-myc IgG clone 9E10 (EQKLISEEDL) to DyLight® 488 Antibody: Mouse monoclonal anti-c-myc (clone 9E10), IgG1 Dye: DyLight® 488 Excitation max. λ: 493 nm Emission max. λ: 518 nm Uses: Flow cytometry, cell-based assays, microarrays, and microplate applications

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SKU:11247 - 100 μg

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Mouse Anti-c-myc IgG:DyLight® 488 – 100 μg

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SKU:11247- 100 μg

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Mouse Anti-c-myc IgG:DyLight® 650 – 100 µg

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SKU:11264- 100 µg

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Mouse Anti-c-myc IgG:DyLight® 650 – 100 µg

Mouse anti-c-myc IgG clone 9E10 (EQKLISEEDL) conjugated to DyLight® 650 Antibody: Mouse monoclonal anti-c-myc (clone 9E10) IgG1 Dye: DyLight® 650 Excitation max. λ: 652 nm Emission max. λ: 672 nm Specificity: Recognizes the 9E10 epitope (EQKLISEEDL sequence) derived from the human c-myc protein. Uses: Flow cytometry, cell-based assays, microarrays, and microplate applications

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SKU:11264 - 100 µg

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Mouse Anti-c-myc IgG:DyLight® 650 – 100 µg

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SKU:11264- 100 µg

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Mouse Anti-c-myc IgG:Eu-W1024 – 1 mg

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SKU:16577- 1 mg

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Mouse Anti-c-myc IgG:Eu-W1024 – 1 mg

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Cayman

SKU:16577- 1 mg

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Mouse Anti-c-myc IgG:Eu-W1024 – 1 mg

Antibody: Mouse mononcolonal anti-c-myc IgG (clone 9E10) Dye: Europium Chelate W-1024 Excitation max. λ: 340 nm Emission max. λ: 615 nm Uses: TR-FRET high throughput screening (HTS) applications (LANCE®, HTRF®) Specificity: Recognizes the 9E10 epitope (EQKLISEEDL sequence) derived from the human c-myc protein.

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SKU:16577 - 1 mg

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Mouse Anti-c-myc IgG:Eu-W1024 – 20 µg

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SKU:16577- 20 µg

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Mouse Anti-c-myc IgG:Eu-W1024 – 20 µg

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SKU:16577- 20 µg

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Mouse Anti-c-myc IgG:Eu-W1024 – 20 µg

Antibody: Mouse mononcolonal anti-c-myc IgG (clone 9E10) Dye: Europium Chelate W-1024 Excitation max. λ: 340 nm Emission max. λ: 615 nm Uses: TR-FRET high throughput screening (HTS) applications (LANCE®, HTRF®) Specificity: Recognizes the 9E10 epitope (EQKLISEEDL sequence) derived from the human c-myc protein.

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SKU:16577 - 20 µg

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Mouse Anti-c-myc IgG:Eu-W1024 – 50 µg

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SKU:16577- 50 µg

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Mouse Anti-c-myc IgG:Eu-W1024 – 50 µg

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SKU:16577- 50 µg

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Mouse Anti-c-myc IgG:Eu-W1024 – 50 µg

Antibody: Mouse mononcolonal anti-c-myc IgG (clone 9E10) Dye: Europium Chelate W-1024 Excitation max. λ: 340 nm Emission max. λ: 615 nm Uses: TR-FRET high throughput screening (HTS) applications (LANCE®, HTRF®) Specificity: Recognizes the 9E10 epitope (EQKLISEEDL sequence) derived from the human c-myc protein.

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SKU:16577 - 50 µg

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Mouse Anti-c-myc IgG:SureLight® APC – 1 mg

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SKU:16602- 1 mg

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Mouse Anti-c-myc IgG:SureLight® APC – 1 mg

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SKU:16602- 1 mg

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Mouse Anti-c-myc IgG:SureLight® APC – 1 mg

Mouse anti-c-myc IgG clone 9E10 (EQKLISEEDL) conjugated to SureLight® APC Antibody: Mouse monoclonal anti-c-Myc IgG, clone 9E10 (EQKLISEEDL) Dye: SureLight® Allophycocyanin (APC) Excitation max. λ: 652 nm Emission max. λ: 657.5 nm Uses: Optimized for High throughput screening (HTS) and fluorescence resonance energy transfer (FRET) assays, flow cytometry

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SKU:16602 - 1 mg

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Mouse Anti-c-myc IgG:SureLight® APC – 100 µg

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SKU:16602- 100 µg

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Mouse Anti-c-myc IgG:SureLight® APC – 100 µg

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SKU:16602- 100 µg

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Mouse Anti-c-myc IgG:SureLight® APC – 100 µg

Mouse anti-c-myc IgG clone 9E10 (EQKLISEEDL) conjugated to SureLight® APC Antibody: Mouse monoclonal anti-c-Myc IgG, clone 9E10 (EQKLISEEDL) Dye: SureLight® Allophycocyanin (APC) Excitation max. λ: 652 nm Emission max. λ: 657.5 nm Uses: Optimized for High throughput screening (HTS) and fluorescence resonance energy transfer (FRET) assays, flow cytometry

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SKU:16602 - 100 µg

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Mouse anti-c-myc IgG:SureLight® P3 – 100 μg

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Cayman

SKU:13455- 100 μg

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Mouse anti-c-myc IgG:SureLight® P3 – 100 μg

Mouse anti-c-myc IgG clone 9E10 (EQKLISEEDL) conjugated to SureLight® P3 Antibody: Mouse monoclonal anti-c-Myc IgG1, clone 9E10 Dye: SureLight® P3 Excitation max. λ: 614 nm Emission max. λ: 662 nm Uses: Flow cytometry, cell-based assays, microarrays, and microplate applications

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SKU:13455 - 100 μg

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Mouse anti-c-myc IgG:SureLight® P3 – 100 μg

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SKU:13455- 100 μg

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Mouse Anti-c-myc IgG:SureLight® PerCP – 100 μg

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Cayman

SKU:11274- 100 μg

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Mouse Anti-c-myc IgG:SureLight® PerCP – 100 μg

Mouse anti-c-myc IgG clone 9E10 (EQKLISEEDL) conjugated to SureLight® PerCP Antibody: Mouse monoclonal anti-c-myc (clone 9E10) IgG1 Dye: SureLight® Peridinin-Chlorophyll (PerCP) Excitation max. λ: 483 nm Emission max. λ: 673 nm Specificity Recognizes the 9E10 epitope (EQKLISEEDL sequence) derived from the human c-myc protein. Uses: Flow cytometry, cell-based assays, microarrays, and microplate applications

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SKU:11274 - 100 μg

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Mouse Anti-c-myc IgG:SureLight® PerCP – 100 μg

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SKU:11274- 100 μg

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Mouse Anti-c-myc IgG:SureLight® R-PE – 100 μg

Brand:
Cayman

SKU:13426- 100 μg

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Mouse Anti-c-myc IgG:SureLight® R-PE – 100 μg

Mouse anti-c-myc IgG clone 9E10 (EQKLISEEDL) to SureLight® R-PE Antibody: Mouse monoclonal anti-c-myc (clone 9E10) IgG1 Dye: SureLight® R-phycoerythrin Excitation max. λ: 565>498 nm Emission max. λ: 578 nm Uses: Flow cytometry, cell-based assays, microarrays, and microplate applications

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SKU:13426 - 100 μg

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Mouse Anti-c-myc IgG:SureLight® R-PE – 100 μg

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SKU:13426- 100 μg

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Mouse Anti-DYKDDDDK (Clone M2) IgG:HRP – 100 µg

Horseradish Peroxidase conjugated to Mouse Anti-DYKDDDDK Antibody: Mouse monoclonal anti-DYKDDDDK (Clone M2) Enzyme: Horseradish Peroxidase Uses: Western blot detection. Recommended dilution of 1:500-1:10,000. Starting dilution: 1:2,000.

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SKU:27096 - 100 µg

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Mouse Anti-DYKDDDDK (Clone M2) IgG:HRP – 100 µg

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SKU:27096- 100 µg

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Mouse Anti-DYKDDDDK (Clone M2) IgG:HRP – 100 µg

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SKU:27096- 100 µg

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Mouse Anti-DYKDDDDK IgG:Alkaline Phosphatase – 100 μg

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Cayman

SKU:13464- 100 μg

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Mouse Anti-DYKDDDDK IgG:Alkaline Phosphatase – 100 μg

Mouse anti-DYKDDDDK IgG (Clone M2) conjugated to Alkaline Phosphatase Antibody: Mouse monoclonal anti-DYKDDDDK IgG, clone M2 Enzyme: Alkaline Phosphatase Uses: Western blot detection. Recommended dilution of 1:500-1:10,000. Starting dilution: 1:2,000.

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SKU:13464 - 100 μg

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Mouse Anti-DYKDDDDK IgG:Alkaline Phosphatase – 100 μg

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SKU:13464- 100 μg

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Mouse Anti-DYKDDDDK IgG:DyLight® 488 – 100 μg

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Cayman

SKU:11248- 100 μg

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Mouse Anti-DYKDDDDK IgG:DyLight® 488 – 100 μg

Mouse anti-DYKDDDDK IgG (Clone M2) conjugated to DyLight® 488 Antibody: Mouse monoclonal anti-DYDDDDK IgG, clone M2 Dye: DyLight® 488 Excitation max. λ: 493 nm Emission max. λ: 518 nm Uses: Flow cytometry, cell-based assays, microarrays, and microplate applications

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SKU:11248 - 100 μg

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Mouse Anti-DYKDDDDK IgG:DyLight® 488 – 100 μg

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SKU:11248- 100 μg

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Mouse Anti-DYKDDDDK IgG:DyLight® 550 – 100 μg

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Cayman

SKU:11256- 100 μg

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Mouse Anti-DYKDDDDK IgG:DyLight® 550 – 100 μg

Mouse anti-DYKDDDDK IgG (Clone M2) conjugated to DyLight® 550 Antibody: Mouse monoclonal anti-DYDDDDK IgG, clone M2 Dye: DyLight® 550 Excitation max. λ: 562 nm Emission max. λ: 576 nm Uses: Flow cytometry, cell-based assays, microarrays, and microplate applications

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SKU:11256 - 100 μg

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Mouse Anti-DYKDDDDK IgG:DyLight® 550 – 100 μg

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SKU:11256- 100 μg

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Mouse Anti-DYKDDDDK IgG:DyLight® 650 – 100 µg

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SKU:11265- 100 µg

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Mouse Anti-DYKDDDDK IgG:DyLight® 650 – 100 µg

Mouse anti-DYKDDDDK IgG (Clone M2) conjugated to DyLight® 650 Antibody: Mouse monoclonal anti-DYDDDDK IgG, clone M2 Dye: DyLight® 650 Excitation max. λ: 652 nm Emission max. λ: 672 nm Uses: Flow cytometry, cell-based assays, microarrays, and microplate applications

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SKU:11265 - 100 µg

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Mouse Anti-DYKDDDDK IgG:DyLight® 650 – 100 µg

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SKU:11265- 100 µg

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Mouse Anti-DYKDDDDK IgG:Eu-W1024 – 1 mg

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SKU:16578- 1 mg

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Mouse Anti-DYKDDDDK IgG:Eu-W1024 – 1 mg

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SKU:16578- 1 mg

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Mouse Anti-DYKDDDDK IgG:Eu-W1024 – 1 mg

Antibody: Mouse mononcolonal anti-DYDDDK IgG (clone M2) Dye: Europium Chelate W-1024 Excitation max. λ: 340 nm Emission max. λ: 615 nm Uses: TR-FRET high throughput screening (HTS) applications (LANCE®, HTRF®)

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SKU:16578 - 1 mg

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Mouse Anti-DYKDDDDK IgG:Eu-W1024 – 20 µg

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SKU:16578- 20 µg

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Mouse Anti-DYKDDDDK IgG:Eu-W1024 – 20 µg

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SKU:16578- 20 µg

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Mouse Anti-DYKDDDDK IgG:Eu-W1024 – 20 µg

Antibody: Mouse mononcolonal anti-DYDDDK IgG (clone M2) Dye: Europium Chelate W-1024 Excitation max. λ: 340 nm Emission max. λ: 615 nm Uses: TR-FRET high throughput screening (HTS) applications (LANCE®, HTRF®)

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SKU:16578 - 20 µg

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Mouse Anti-DYKDDDDK IgG:Eu-W1024 – 50 µg

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SKU:16578- 50 µg

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Mouse Anti-DYKDDDDK IgG:Eu-W1024 – 50 µg

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SKU:16578- 50 µg

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Mouse Anti-DYKDDDDK IgG:Eu-W1024 – 50 µg

Antibody: Mouse mononcolonal anti-DYDDDK IgG (clone M2) Dye: Europium Chelate W-1024 Excitation max. λ: 340 nm Emission max. λ: 615 nm Uses: TR-FRET high throughput screening (HTS) applications (LANCE®, HTRF®)

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SKU:16578 - 50 µg

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Mouse Anti-DYKDDDDK IgG:SureLight® APC – 1 mg

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SKU:13404- 1 mg

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Mouse Anti-DYKDDDDK IgG:SureLight® APC – 1 mg

Mouse anti-DYKDDDDK IgG (Clone M2) conjugated to SureLight® APC Antibody: Mouse monoclonal anti-DYKDDDDK IgG, clone M2 Dye: SureLight® Allophycocyanin (APC) Excitation max. λ: 652 nm Emission max. λ: 657.5 nm Uses: Optimized for High throughput screening (HTS) and fluorescence resonance energy transfer (FRET) assays, flow cytometry

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SKU:13404 - 1 mg

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Mouse Anti-DYKDDDDK IgG:SureLight® APC – 1 mg

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SKU:13404- 1 mg

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Mouse Anti-DYKDDDDK IgG:SureLight® APC – 100 µg

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SKU:13404- 100 µg

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Mouse Anti-DYKDDDDK IgG:SureLight® APC – 100 µg

Mouse anti-DYKDDDDK IgG (Clone M2) conjugated to SureLight® APC Antibody: Mouse monoclonal anti-DYKDDDDK IgG, clone M2 Dye: SureLight® Allophycocyanin (APC) Excitation max. λ: 652 nm Emission max. λ: 657.5 nm Uses: Optimized for High throughput screening (HTS) and fluorescence resonance energy transfer (FRET) assays, flow cytometry

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SKU:13404 - 100 µg

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Mouse Anti-DYKDDDDK IgG:SureLight® APC – 100 µg

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SKU:13404- 100 µg

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Mouse Anti-DYKDDDDK IgG:SureLight® PerCP – 100 μg

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SKU:11275- 100 μg

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Mouse Anti-DYKDDDDK IgG:SureLight® PerCP – 100 μg

Mouse anti-DYKDDDDK IgG (Clone M2) conjugated to SureLight® PerCP Antibody: Mouse monoclonal anti-DYDDDDK IgG, clone M2 Dye: SureLight® Peridinin-Chlorophyll (PerCP) Excitation max. λ: 483 nm Emission max. λ: 673 nm Uses: Flow cytometry, cell-based assays, microarrays, and microplate applications

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SKU:11275 - 100 μg

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Mouse Anti-DYKDDDDK IgG:SureLight® PerCP – 100 μg

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SKU:11275- 100 μg

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Mouse Anti-DYKDDDDK IgG:SureLight® R-PE – 100 μg

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SKU:13427- 100 μg

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Mouse Anti-DYKDDDDK IgG:SureLight® R-PE – 100 μg

Mouse anti-DYKDDDDK IgG (Clone M2) conjugated to SureLight® R-PE Antibody: Mouse monoclonal anti-DYDDDDK IgG, clone M2 Dye: SureLight® R-phycoerythrin Excitation max. λ: 565>498 nm Emission max. λ: 578 nm Uses: Flow cytometry, cell-based assays, microarrays, and microplate applications

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SKU:13427 - 100 μg

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Mouse Anti-DYKDDDDK IgG:SureLight® R-PE – 100 μg

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SKU:13427- 100 μg

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Mouse Anti-DYKDDDDK IgG:SureLight™ 488 – 100 µg

Mouse IgG monoclonal against popular epitope tag, 6-histidine peptide conjugated to SureLight™ 488. Antibody: Anti-DYKDDDDK Concentration: 100 µg/ml

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SKU:27095 - 100 µg

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Mouse Anti-DYKDDDDK IgG:SureLight™ 488 – 100 µg

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SKU:27095- 100 µg

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Mouse Anti-DYKDDDDK IgG:SureLight™ 488 – 100 µg

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SKU:27095- 100 µg

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Mouse Anti-Fluorescein IgG:SureLight® R-PE – 100 µg

Mouse anti-Fluorescein IgG2a (clone 027-11741) conjugated to SureLight® R-PE Antibody: Mouse anti-Fluorescein (FITC) IgG2a (clone 027-11741) Dye: SureLight® R-phycoerythrin Excitation max. λ: 565>498 nm Emission max. λ: 578 nm Uses: Flow cytometry, cell-based assays, microarrays, and microplate applications

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SKU:16691 - 100 µg

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Mouse Anti-Fluorescein IgG:SureLight® R-PE – 100 µg

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SKU:16691- 100 µg

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Mouse Anti-Fluorescein IgG:SureLight® R-PE – 100 µg

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SKU:16691- 100 µg

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Mouse Anti-HA IgG:Alkaline Phosphatase – 100 μg

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Cayman

SKU:13465- 100 μg

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Mouse Anti-HA IgG:Alkaline Phosphatase – 100 μg

This mouse anti-HA tag IgG is conjugated to Alkaline Phosphatase for direct immunofluorescent detection of HA tag fusion proteins. Antibody: Mouse monoclonal anti-HA.11 (haemagglutinin) IgG, clone 16B12 Specificity: Monoclonal antibody HA.11 was raised against the twelve amino acid peptide CYPYDVPDYASL. The HA.11 antibody recognizes the influenza hemagglutinin epitope (YPYDVPDYA) which has been used extensively as a general epitope tag in expression vectors. The HA.11 antibody recognizes HA epitopes located in the middle of protein sequences as well as at the N- or C-terminus. Enzyme: Alkaline Phosphatase Uses: Western blot detection. Recommended dilution of 1:500-1:10,000. Starting dilution: 1:2,000.

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SKU:13465 - 100 μg

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Mouse Anti-HA IgG:Alkaline Phosphatase – 100 μg

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SKU:13465- 100 μg

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Mouse Anti-HA IgG:Biotin – 100 μg

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Cayman

SKU:13470- 100 μg

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Mouse Anti-HA IgG:Biotin – 100 μg

Mouse anti-HA (Hemagglutinin) IgG1 (Clone 16B12) conjugated to Biotin Antibody: Mouse monoclonal anti-HA (haemagglutinin) IgG, clone 16B12 Binding Moiety: Biotin Uses: Western blot detection. Recommended dilution of 1:500-1:10,000. Starting dilution: 1:2,000.

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SKU:13470 - 100 μg

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Mouse Anti-HA IgG:Biotin – 100 μg

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SKU:13470- 100 μg

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Mouse Anti-HA IgG:DyLight® 488 – 100 μg

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Cayman

SKU:11249- 100 μg

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Mouse Anti-HA IgG:DyLight® 488 – 100 μg

Mouse anti-HA (Hemagglutinin) IgG1 (Clone 16B12) conjugated to DyLight® 488 Antibody: Mouse anti-Hemagglutinin IgG (clone 16B12) Dye: DyLight® 488 Excitation max. λ: 493 nm Emission max. λ: 518 nm Uses: Flow cytometry and cell-based assays

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SKU:11249 - 100 μg

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Mouse Anti-HA IgG:DyLight® 488 – 100 μg

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SKU:11249- 100 μg

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Mouse Anti-HA IgG:DyLight® 550 – 100 μg

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Cayman

SKU:11257- 100 μg

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Mouse Anti-HA IgG:DyLight® 550 – 100 μg

Mouse anti-HA (Hemagglutinin) IgG1 (Clone 16B12) conjugated to DyLight® 550 Antibody: Mouse anti-Hemagglutinin IgG (clone 16B12) Dye: DyLight® 550 Excitation max. λ: 562 nm Emission max. λ: 576 nm Uses: Flow cytometry and cell-based assays

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SKU:11257 - 100 μg

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Mouse Anti-HA IgG:DyLight® 550 – 100 μg

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SKU:11257- 100 μg

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Mouse Anti-HA IgG:DyLight® 650 – 100 µg

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Cayman

SKU:11266- 100 µg

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Mouse Anti-HA IgG:DyLight® 650 – 100 µg

Mouse anti-HA (Hemagglutinin) IgG1 (Clone 16B12) conjugated to DyLight® 650 Antibody: Mouse anti-Hemagglutinin IgG (clone 16B12) Dye: DyLight® 650 Excitation max. λ: 652 nm Emission max. λ: 672 nm Uses: Flow cytometry and cell-based assays

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SKU:11266 - 100 µg

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Mouse Anti-HA IgG:DyLight® 650 – 100 µg

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SKU:11266- 100 µg

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Mouse Anti-HA IgG:Eu-W1024 – 1 mg

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Cayman

SKU:16579- 1 mg

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Mouse Anti-HA IgG:Eu-W1024 – 1 mg

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Cayman

SKU:16579- 1 mg

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Mouse Anti-HA IgG:Eu-W1024 – 1 mg

Antibody: Mouse mononcolonal anti-Hemagglutinin IgG (clone 16B12) Dye: Europium Chelate W-1024 Excitation max. λ: 340 nm Emission max. λ: 615 nm Uses: TR-FRET high throughput screening (HTS) applications (LANCE®, HTRF®)

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SKU:16579 - 1 mg

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Mouse Anti-HA IgG:Eu-W1024 – 20 µg

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SKU:16579- 20 µg

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Mouse Anti-HA IgG:Eu-W1024 – 20 µg

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Cayman

SKU:16579- 20 µg

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Mouse Anti-HA IgG:Eu-W1024 – 20 µg

Antibody: Mouse mononcolonal anti-Hemagglutinin IgG (clone 16B12) Dye: Europium Chelate W-1024 Excitation max. λ: 340 nm Emission max. λ: 615 nm Uses: TR-FRET high throughput screening (HTS) applications (LANCE®, HTRF®)

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SKU:16579 - 20 µg

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Mouse Anti-HA IgG:Eu-W1024 – 50 µg

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SKU:16579- 50 µg

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Mouse Anti-HA IgG:Eu-W1024 – 50 µg

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SKU:16579- 50 µg

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Mouse Anti-HA IgG:Eu-W1024 – 50 µg

Antibody: Mouse mononcolonal anti-Hemagglutinin IgG (clone 16B12) Dye: Europium Chelate W-1024 Excitation max. λ: 340 nm Emission max. λ: 615 nm Uses: TR-FRET high throughput screening (HTS) applications (LANCE®, HTRF®)

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SKU:16579 - 50 µg

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Mouse Anti-HA IgG:HRP – 100 µg

Mouse anti-HA (Hemagglutinin) IgG1 (Clone 16B12) HRP Antibody: Mouse monoclonal anti-HA.11 (haemagglutinin) IgG, clone 16B12 Specificity: Monoclonal antibody HA.11 was raised against the twelve amino acid peptide CYPYDVPDYASL. The HA.11 antibody recognizes the influenza hemagglutinin epitope (YPYDVPDYA) which has been used extensively as a general epitope tag in expression vectors. The HA.11 antibody recognizes HA epitopes located in the middle of protein sequences as well as at the N- or C-terminus. Enzyme: Horseradish Peroxidase Uses: Western blot detection. Recommended dilution of 1:500-1:10,000. Starting dilution: 1:2,000.

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SKU:16746 - 100 µg

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Mouse Anti-HA IgG:HRP – 100 µg

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SKU:16746- 100 µg

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Mouse Anti-HA IgG:HRP – 100 µg

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Cayman

SKU:16746- 100 µg

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Mouse Anti-HA IgG:SureLight® PerCP – 100 μg

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Cayman

SKU:11276- 100 μg

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Mouse Anti-HA IgG:SureLight® PerCP – 100 μg

Mouse anti-HA (Hemagglutinin) IgG1 (Clone 16B12) conjugated to SureLight® PerCP Antibody: Mouse monoclonal anti-HA (Hemagglutinin) IgG1, clone 16B12 Specificity: Monoclonal antibody HA.11 was raised against the twelve amino acid peptide CYPYDVPDYASL. The HA.11 antibody recognizes the influenza hemagglutinin epitope (YPYDVPDYA) which has been used extensively as a general epitope tag in expression vectors. The HA.11 antibody recognizes HA epitopes located in the middle of protein sequences as well as at the N- or C-terminus. Dye: SureLight® Peridinin-Chlorophyll (PerCP) Excitation max. λ: 483 nm Emission max. λ: 673 nm Uses: Flow cytometry, cell-based assays, microarrays, and microplate applications

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SKU:11276 - 100 μg

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Mouse Anti-HA IgG:SureLight® PerCP – 100 μg

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SKU:11276- 100 μg

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Mouse Anti-HA IgG:SureLight® R-PE – 100 μg

Brand:
Cayman

SKU:13429- 100 μg

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Mouse Anti-HA IgG:SureLight® R-PE – 100 μg

Mouse anti-HA (Hemagglutinin) IgG1 (Clone 16B12) conjugated to SureLight® R-PE Antibody: Mouse monoclonal anti-HA (Hemagglutinin) IgG1, clone 16B12 Specificity: Monoclonal antibody HA.11 was raised against the twelve amino acid peptide CYPYDVPDYASL. The HA.11 antibody recognizes the influenza hemagglutinin epitope (YPYDVPDYA) which has been used extensively as a general epitope tag in expression vectors. The HA.11 antibody recognizes HA epitopes located in the middle of protein sequences as well as at the N- or C-terminus. Dye: SureLight® R-phycoerythrin Excitation max. λ: 565>498 nm Emission max. λ: 578 nm Uses: Flow cytometry, cell-based assays, microarrays, and microplate applications

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SKU:13429 - 100 μg

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Mouse Anti-HA IgG:SureLight® R-PE – 100 μg

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SKU:13429- 100 μg

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Mouse Anti-HRP IgG:SureLight® R-PE – 100 µg

Mouse anti-HRP IgG2b (clone 3P/2H11) conjugated to SureLight® R-PE Antibody: Mouse anti-Horseradish Peroxidase (HRP) IgG2b (clone 3P/2H11) Dye: SureLight® R-phycoerythrin Excitation max. λ: 565>498 nm Emission max. λ: 578 nm Uses: Flow cytometry, cell-based assays, microarrays, and microplate applications

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Cayman

SKU:16692 - 100 µg

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Mouse Anti-HRP IgG:SureLight® R-PE – 100 µg

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SKU:16692- 100 µg

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Mouse Anti-HRP IgG:SureLight® R-PE – 100 µg

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SKU:16692- 100 µg

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Mouse Anti-Type II Collagen IgG Assay Kit (bovine) – 96 wells

Collagen-induced arthritis (CIA) is an experimental autoimmune disease that is widely used as a model of human rheumatoid arthritis (RA) in the study of the pathogenic mechanisms of this disease and for testing potential therapeutics. Circulating levels of anti-type II collagen antibody are strongly associated with the development of arthritis and can be used as a biomarker of CIA. Cayman’s Mouse Anti-Type II Collagen IgG Assay is an immunometric (i.e., sandwich) assay which can be used to measure anti-type II collagen antibody in plasma or serum without prior sample purification. This kit uses a bovine collagen-coated plate and an affinity-purified polyclonal antibody isolated from mice with CIA as a standard. This standard provides the most accurate measurement of anti-CII concentration in experimental plasma samples. One unit of standard in this assay is approximately equal to 1 ng of IgG protein. The standard curve spans the range of 15.6-1,000 U/ml, with an LLOQ of 15.6 U/ml.

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SKU:500410 - 96 wells

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Mouse Anti-Type II Collagen Polyclonal IgG Standard – 1 ea

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SKU:400407 - 1 ea

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Mouse Anti-Type II Collagen Polyclonal IgG Standard – 1 ea

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SKU:400407- 1 ea

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Mouse Anti-Type II Collagen Polyclonal IgG Standard – 1 ea

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Cayman

SKU:400407- 1 ea

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Mouse IgG ELISA Kit – 96 wells

Immunoglobulin IgG provides the majority of antibody-based immunity against invading pathogens and plays a significant role in the pathology of auto-immune diseases. Most mouse monoclonal antibodies are of the IgG isotype. Because mice are widely used as a research model for studies of the immune system, various diseases, and drug development, mouse monoclonal antibodies have become an important tool in biochemistry, molecular biology, and medicine. There are multiple applications for a sensitive assay to accurately quantify the concentration of mouse IgG in complex sample matrices. Cayman’s Mouse IgG ELISA Kit is a sandwich assay that can be used to measure IgG in mouse plasma, mouse serum, cell culture supernatants, and ascites without prior sample purification. The standard curve spans the range of 1.6-100 ng/ml with an LLOQ of 1.6 ng/ml. The reported measured levels of IgG in mouse serum range between 2 and 22 mg/ml.

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Cayman

SKU:501240 - 96 wells

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Moxalactam (sodium salt) – 1 g

Moxalactam is a β-lactam antibiotic in the cephalosporin class. It is classified as an oxacephem, as oxygen replaces sulfur in position one of the dihydrothiazolidine ring.{25856} While moxalactam inhibits most commonly occurring gram positive, gram negative, and anaerobic bacteria, it is ineffective against methicillin-resistant S. aureus and Enterococci.{25856} In certain situations, this antibiotic impairs normal hemostasis, most commonly manifested as a prolonged bleeding time.{25855}

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Moxalactam (sodium salt) – 250 mg

Moxalactam is a β-lactam antibiotic in the cephalosporin class. It is classified as an oxacephem, as oxygen replaces sulfur in position one of the dihydrothiazolidine ring.{25856} While moxalactam inhibits most commonly occurring gram positive, gram negative, and anaerobic bacteria, it is ineffective against methicillin-resistant S. aureus and Enterococci.{25856} In certain situations, this antibiotic impairs normal hemostasis, most commonly manifested as a prolonged bleeding time.{25855}

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Moxalactam (sodium salt) – 500 mg

Moxalactam is a β-lactam antibiotic in the cephalosporin class. It is classified as an oxacephem, as oxygen replaces sulfur in position one of the dihydrothiazolidine ring.{25856} While moxalactam inhibits most commonly occurring gram positive, gram negative, and anaerobic bacteria, it is ineffective against methicillin-resistant S. aureus and Enterococci.{25856} In certain situations, this antibiotic impairs normal hemostasis, most commonly manifested as a prolonged bleeding time.{25855}

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Moxidectin – 10 mg

Moxidectin is a macrocyclic lactone endectocide and a derivative of nemadectin (Item No. 17454).{28538,45405} It reduces fecal nematode egg counts by 98.4 and 99.8% in naturally infected calves when administered subcutaneously at doses of 0.2 and 0.3 mg/kg, respectively.{45405} Moxidectin (0.2 and 0.3 mg/kg) reduces the worm burden of O. ostertagi and T. axei in the abomasum, and Cooperia species and N. helvetianus in the small intestine, of naturally infected calves. It potentiates GABA-gated currents in Xenopus oocytes expressing rat α1β2γ2 subunit-containing GABAA receptors with an EC50 value of 11.8 nM.{45406} Formulations containing moxidectin have been used in the treatment of onchocerciasis, as well as in the prevention and treatment of parasitic infections in veterinary medicine.

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Moxidectin – 25 mg

Moxidectin is a macrocyclic lactone endectocide and a derivative of nemadectin (Item No. 17454).{28538,45405} It reduces fecal nematode egg counts by 98.4 and 99.8% in naturally infected calves when administered subcutaneously at doses of 0.2 and 0.3 mg/kg, respectively.{45405} Moxidectin (0.2 and 0.3 mg/kg) reduces the worm burden of O. ostertagi and T. axei in the abomasum, and Cooperia species and N. helvetianus in the small intestine, of naturally infected calves. It potentiates GABA-gated currents in Xenopus oocytes expressing rat α1β2γ2 subunit-containing GABAA receptors with an EC50 value of 11.8 nM.{45406} Formulations containing moxidectin have been used in the treatment of onchocerciasis, as well as in the prevention and treatment of parasitic infections in veterinary medicine.

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Moxidectin – 5 mg

Moxidectin is a macrocyclic lactone endectocide and a derivative of nemadectin (Item No. 17454).{28538,45405} It reduces fecal nematode egg counts by 98.4 and 99.8% in naturally infected calves when administered subcutaneously at doses of 0.2 and 0.3 mg/kg, respectively.{45405} Moxidectin (0.2 and 0.3 mg/kg) reduces the worm burden of O. ostertagi and T. axei in the abomasum, and Cooperia species and N. helvetianus in the small intestine, of naturally infected calves. It potentiates GABA-gated currents in Xenopus oocytes expressing rat α1β2γ2 subunit-containing GABAA receptors with an EC50 value of 11.8 nM.{45406} Formulations containing moxidectin have been used in the treatment of onchocerciasis, as well as in the prevention and treatment of parasitic infections in veterinary medicine.

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Moxidectin – 50 mg

Moxidectin is a macrocyclic lactone endectocide and a derivative of nemadectin (Item No. 17454).{28538,45405} It reduces fecal nematode egg counts by 98.4 and 99.8% in naturally infected calves when administered subcutaneously at doses of 0.2 and 0.3 mg/kg, respectively.{45405} Moxidectin (0.2 and 0.3 mg/kg) reduces the worm burden of O. ostertagi and T. axei in the abomasum, and Cooperia species and N. helvetianus in the small intestine, of naturally infected calves. It potentiates GABA-gated currents in Xenopus oocytes expressing rat α1β2γ2 subunit-containing GABAA receptors with an EC50 value of 11.8 nM.{45406} Formulations containing moxidectin have been used in the treatment of onchocerciasis, as well as in the prevention and treatment of parasitic infections in veterinary medicine.

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Moxifloxacin (hydrochloride) – 1 g

Moxifloxacin is a fluoroquinolone antibiotic.{53219} It is active against 390 clinical isolates of aerobic and anaerobic Gram-positive and Gram-negative bacteria (MIC90s = ≤0.25 µg/ml), as well as clinical isolates of methicillin-susceptible and -resistant S. aureus (MIC90s = 0.12 and 2 µg/ml, respectively).{53219,53220} Moxifloxacin is an inhibitor of E. coli DNA gyrase that is selective for DNA gyrase over E. coli topoisomerase IV (IC50s = 0.51 and 38.8 mg/L, respectively, in cell-free assays).{53221} It prevents S. aureus- or P. aeruginosa-induced increases in bronchoalveolar lavage fluid (BALF) neutrophil infiltration and reduces S. aureus- or P. aeruginosa-induced increases in lung chemokine (C-X-C motif) ligand 1 (CXCL1) and IL-1β levels in mouse models of bacterial pneumonia when administered at a dose of 100 mg/kg twice per day for two days.{53222} Moxifloxacin (100 mg/kg) decreases the number of lung and spleen colony forming units (CFUs) in a mouse model of systemic M. tuberculosis infection.{53223} Formulations containing moxifloxacin have been used in the treatment of various bacterial infections.

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Moxifloxacin (hydrochloride) – 100 mg

Moxifloxacin is a fluoroquinolone antibiotic.{53219} It is active against 390 clinical isolates of aerobic and anaerobic Gram-positive and Gram-negative bacteria (MIC90s = ≤0.25 µg/ml), as well as clinical isolates of methicillin-susceptible and -resistant S. aureus (MIC90s = 0.12 and 2 µg/ml, respectively).{53219,53220} Moxifloxacin is an inhibitor of E. coli DNA gyrase that is selective for DNA gyrase over E. coli topoisomerase IV (IC50s = 0.51 and 38.8 mg/L, respectively, in cell-free assays).{53221} It prevents S. aureus- or P. aeruginosa-induced increases in bronchoalveolar lavage fluid (BALF) neutrophil infiltration and reduces S. aureus- or P. aeruginosa-induced increases in lung chemokine (C-X-C motif) ligand 1 (CXCL1) and IL-1β levels in mouse models of bacterial pneumonia when administered at a dose of 100 mg/kg twice per day for two days.{53222} Moxifloxacin (100 mg/kg) decreases the number of lung and spleen colony forming units (CFUs) in a mouse model of systemic M. tuberculosis infection.{53223} Formulations containing moxifloxacin have been used in the treatment of various bacterial infections.

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Moxifloxacin (hydrochloride) – 50 mg

Moxifloxacin is a fluoroquinolone antibiotic.{53219} It is active against 390 clinical isolates of aerobic and anaerobic Gram-positive and Gram-negative bacteria (MIC90s = ≤0.25 µg/ml), as well as clinical isolates of methicillin-susceptible and -resistant S. aureus (MIC90s = 0.12 and 2 µg/ml, respectively).{53219,53220} Moxifloxacin is an inhibitor of E. coli DNA gyrase that is selective for DNA gyrase over E. coli topoisomerase IV (IC50s = 0.51 and 38.8 mg/L, respectively, in cell-free assays).{53221} It prevents S. aureus- or P. aeruginosa-induced increases in bronchoalveolar lavage fluid (BALF) neutrophil infiltration and reduces S. aureus- or P. aeruginosa-induced increases in lung chemokine (C-X-C motif) ligand 1 (CXCL1) and IL-1β levels in mouse models of bacterial pneumonia when administered at a dose of 100 mg/kg twice per day for two days.{53222} Moxifloxacin (100 mg/kg) decreases the number of lung and spleen colony forming units (CFUs) in a mouse model of systemic M. tuberculosis infection.{53223} Formulations containing moxifloxacin have been used in the treatment of various bacterial infections.

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Moxifloxacin (hydrochloride) – 500 mg

Moxifloxacin is a fluoroquinolone antibiotic.{53219} It is active against 390 clinical isolates of aerobic and anaerobic Gram-positive and Gram-negative bacteria (MIC90s = ≤0.25 µg/ml), as well as clinical isolates of methicillin-susceptible and -resistant S. aureus (MIC90s = 0.12 and 2 µg/ml, respectively).{53219,53220} Moxifloxacin is an inhibitor of E. coli DNA gyrase that is selective for DNA gyrase over E. coli topoisomerase IV (IC50s = 0.51 and 38.8 mg/L, respectively, in cell-free assays).{53221} It prevents S. aureus- or P. aeruginosa-induced increases in bronchoalveolar lavage fluid (BALF) neutrophil infiltration and reduces S. aureus- or P. aeruginosa-induced increases in lung chemokine (C-X-C motif) ligand 1 (CXCL1) and IL-1β levels in mouse models of bacterial pneumonia when administered at a dose of 100 mg/kg twice per day for two days.{53222} Moxifloxacin (100 mg/kg) decreases the number of lung and spleen colony forming units (CFUs) in a mouse model of systemic M. tuberculosis infection.{53223} Formulations containing moxifloxacin have been used in the treatment of various bacterial infections.

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Moxonidine – 10 mg

Moxonidine is an imidazoline 1 (I1) receptor agonist (Ki = 56 nM in a radioligand binding assay).{47043} It is also an agonist of the α2A-adrenergic receptor (α2A-AR; Ki = 150 nM in a radioligand binding assay). It is selective for I1 and α2A-AR receptors over α1-, α2B, and α2C-ARs (Kis = >30,000, 1,000, and 2,000 nM, respectively). Moxonidine decreases mean arterial pressure in spontaneously hypertensive rats when administered at a dose of 0.2 nmol injected into the rostral ventrolateral medulla oblongata (RVLM).{47044} It also reduces blood pressure in cynomolgus monkeys when administered at a dose of 167 µg/kg.{47043}

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SKU:25639 - 10 mg

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Moxonidine – 100 mg

Moxonidine is an imidazoline 1 (I1) receptor agonist (Ki = 56 nM in a radioligand binding assay).{47043} It is also an agonist of the α2A-adrenergic receptor (α2A-AR; Ki = 150 nM in a radioligand binding assay). It is selective for I1 and α2A-AR receptors over α1-, α2B, and α2C-ARs (Kis = >30,000, 1,000, and 2,000 nM, respectively). Moxonidine decreases mean arterial pressure in spontaneously hypertensive rats when administered at a dose of 0.2 nmol injected into the rostral ventrolateral medulla oblongata (RVLM).{47044} It also reduces blood pressure in cynomolgus monkeys when administered at a dose of 167 µg/kg.{47043}

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SKU:25639 - 100 mg

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Moxonidine – 250 mg

Moxonidine is an imidazoline 1 (I1) receptor agonist (Ki = 56 nM in a radioligand binding assay).{47043} It is also an agonist of the α2A-adrenergic receptor (α2A-AR; Ki = 150 nM in a radioligand binding assay). It is selective for I1 and α2A-AR receptors over α1-, α2B, and α2C-ARs (Kis = >30,000, 1,000, and 2,000 nM, respectively). Moxonidine decreases mean arterial pressure in spontaneously hypertensive rats when administered at a dose of 0.2 nmol injected into the rostral ventrolateral medulla oblongata (RVLM).{47044} It also reduces blood pressure in cynomolgus monkeys when administered at a dose of 167 µg/kg.{47043}

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SKU:25639 - 250 mg

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Moxonidine – 50 mg

Moxonidine is an imidazoline 1 (I1) receptor agonist (Ki = 56 nM in a radioligand binding assay).{47043} It is also an agonist of the α2A-adrenergic receptor (α2A-AR; Ki = 150 nM in a radioligand binding assay). It is selective for I1 and α2A-AR receptors over α1-, α2B, and α2C-ARs (Kis = >30,000, 1,000, and 2,000 nM, respectively). Moxonidine decreases mean arterial pressure in spontaneously hypertensive rats when administered at a dose of 0.2 nmol injected into the rostral ventrolateral medulla oblongata (RVLM).{47044} It also reduces blood pressure in cynomolgus monkeys when administered at a dose of 167 µg/kg.{47043}

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SKU:25639 - 50 mg

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MOZ-IN-2 – 1 mg

MOZ-IN-2 is an inhibitor of lysine acetyltransferase 6A (KAT6A/MOZ; IC50 = 125 µM).{54159}

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SKU:27686 - 1 mg

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MOZ-IN-2 – 10 mg

MOZ-IN-2 is an inhibitor of lysine acetyltransferase 6A (KAT6A/MOZ; IC50 = 125 µM).{54159}

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SKU:27686 - 10 mg

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MOZ-IN-2 – 25 mg

MOZ-IN-2 is an inhibitor of lysine acetyltransferase 6A (KAT6A/MOZ; IC50 = 125 µM).{54159}

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SKU:27686 - 25 mg

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MOZ-IN-2 – 5 mg

MOZ-IN-2 is an inhibitor of lysine acetyltransferase 6A (KAT6A/MOZ; IC50 = 125 µM).{54159}

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SKU:27686 - 5 mg

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MOZ-IN-3 – 1 mg

MOZ-IN-3 is an inhibitor of lysine acetyltransferase 6A (KAT6A/MOZ) and KAT6B/MORF (IC50s = 8 and 28 nM, respectively).{51034} It is selective for KAT6A and KAT6B over KAT5 and KAT7 (IC50s = 224 and 342 nM, respectively). MOZ-IN-3 induces cell cycle arrest in and inhibits proliferation of mouse embryonic fibroblasts (IC50 = 2.4 µM) and inhibits proliferation of EMRK1184 lymphoma cells (IC50 = 2.3 µM). It induces genetic and morphological changes associated with cellular senescence without inducing DNA damage, apoptosis, or necrosis. MOZ-IN-3 (10 µM) decreases global levels of acetylated histone H3 lysine 14 (H3K14Ac) by 49% and reduces H3K9Ac levels at the transcription start sites of Ezh2, Melk, and E2f2.

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SKU:27402 - 1 mg

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MOZ-IN-3 – 5 mg

MOZ-IN-3 is an inhibitor of lysine acetyltransferase 6A (KAT6A/MOZ) and KAT6B/MORF (IC50s = 8 and 28 nM, respectively).{51034} It is selective for KAT6A and KAT6B over KAT5 and KAT7 (IC50s = 224 and 342 nM, respectively). MOZ-IN-3 induces cell cycle arrest in and inhibits proliferation of mouse embryonic fibroblasts (IC50 = 2.4 µM) and inhibits proliferation of EMRK1184 lymphoma cells (IC50 = 2.3 µM). It induces genetic and morphological changes associated with cellular senescence without inducing DNA damage, apoptosis, or necrosis. MOZ-IN-3 (10 µM) decreases global levels of acetylated histone H3 lysine 14 (H3K14Ac) by 49% and reduces H3K9Ac levels at the transcription start sites of Ezh2, Melk, and E2f2.

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SKU:27402 - 5 mg

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MOZ-IN-3 – 500 µg

MOZ-IN-3 is an inhibitor of lysine acetyltransferase 6A (KAT6A/MOZ) and KAT6B/MORF (IC50s = 8 and 28 nM, respectively).{51034} It is selective for KAT6A and KAT6B over KAT5 and KAT7 (IC50s = 224 and 342 nM, respectively). MOZ-IN-3 induces cell cycle arrest in and inhibits proliferation of mouse embryonic fibroblasts (IC50 = 2.4 µM) and inhibits proliferation of EMRK1184 lymphoma cells (IC50 = 2.3 µM). It induces genetic and morphological changes associated with cellular senescence without inducing DNA damage, apoptosis, or necrosis. MOZ-IN-3 (10 µM) decreases global levels of acetylated histone H3 lysine 14 (H3K14Ac) by 49% and reduces H3K9Ac levels at the transcription start sites of Ezh2, Melk, and E2f2.

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SKU:27402 - 500 µg

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Mozavaptan (hydrochloride) – 10 mg

Mozavaptan is an orally bioavailable antagonist of vasopressin V2 receptors (Ki = 9.42 nM in HeLa cells expressing the human receptor).{27292,59329} It is selective for vasopressin V2 over V1 receptors (IC50s = 14 and 1,200 nM, respectively) in radioligand binding assays using rat kidney and rat liver membranes that endogenously express high levels of vasopressin V2 and V1 receptors, respectively.{27292} Mozavaptan (10-30 mg/kg, p.o.) increases urine volume and decreases urine osmolality, indicating aquaresis, in conscious rats. It reduces decreases in urine flow and increases in urine osmolality induced by arginine vasopressin (AVP; Item No. 24154) in anesthetized rats when administered intravenously at doses ranging from 10 to 100 µg/kg.

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Mozavaptan (hydrochloride) – 100 mg

Mozavaptan is an orally bioavailable antagonist of vasopressin V2 receptors (Ki = 9.42 nM in HeLa cells expressing the human receptor).{27292,59329} It is selective for vasopressin V2 over V1 receptors (IC50s = 14 and 1,200 nM, respectively) in radioligand binding assays using rat kidney and rat liver membranes that endogenously express high levels of vasopressin V2 and V1 receptors, respectively.{27292} Mozavaptan (10-30 mg/kg, p.o.) increases urine volume and decreases urine osmolality, indicating aquaresis, in conscious rats. It reduces decreases in urine flow and increases in urine osmolality induced by arginine vasopressin (AVP; Item No. 24154) in anesthetized rats when administered intravenously at doses ranging from 10 to 100 µg/kg.

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Mozavaptan (hydrochloride) – 5 mg

Mozavaptan is an orally bioavailable antagonist of vasopressin V2 receptors (Ki = 9.42 nM in HeLa cells expressing the human receptor).{27292,59329} It is selective for vasopressin V2 over V1 receptors (IC50s = 14 and 1,200 nM, respectively) in radioligand binding assays using rat kidney and rat liver membranes that endogenously express high levels of vasopressin V2 and V1 receptors, respectively.{27292} Mozavaptan (10-30 mg/kg, p.o.) increases urine volume and decreases urine osmolality, indicating aquaresis, in conscious rats. It reduces decreases in urine flow and increases in urine osmolality induced by arginine vasopressin (AVP; Item No. 24154) in anesthetized rats when administered intravenously at doses ranging from 10 to 100 µg/kg.

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Mozavaptan (hydrochloride) – 50 mg

Mozavaptan is an orally bioavailable antagonist of vasopressin V2 receptors (Ki = 9.42 nM in HeLa cells expressing the human receptor).{27292,59329} It is selective for vasopressin V2 over V1 receptors (IC50s = 14 and 1,200 nM, respectively) in radioligand binding assays using rat kidney and rat liver membranes that endogenously express high levels of vasopressin V2 and V1 receptors, respectively.{27292} Mozavaptan (10-30 mg/kg, p.o.) increases urine volume and decreases urine osmolality, indicating aquaresis, in conscious rats. It reduces decreases in urine flow and increases in urine osmolality induced by arginine vasopressin (AVP; Item No. 24154) in anesthetized rats when administered intravenously at doses ranging from 10 to 100 µg/kg.

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MP-A08 – 1 mg

MP-A08 is an ATP-competitive inhibitor of sphingosine kinases (SKs) 1 and 2 (Kis = 27 and 6.9 μM, respectively).{38144} It is selective for SK1/2 over a panel of 140 human protein kinases at concentrations up to 25 μM. MP-A08 (15 μM) reduces generation of cellular sphingosine-1-phosphate (S1P; Item No. 62570) without inducing degradation of SK1 in Jurkat cells. It induces a 3.7-, 3.5-, and 5.8-fold increase in C-18 ceramide (Item No. 19556), C-20 ceramide (Item No. 10724), and C20:1-ceramide levels, respectively, and dose-dependently activates the apoptosis-associated p38 and JNK pathways in vitro. MP-A08 reduces proliferation of a variety of human cancer cell lines (EC50s = 8-44.9 μM). MP-A08 also reduces tumor vasculature, as determined by CD31 staining, and volume as well as S1P protein levels in A549 human lung adenocarcinoma xenografts in mice.

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SKU:21903 -

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MP-A08 – 10 mg

MP-A08 is an ATP-competitive inhibitor of sphingosine kinases (SKs) 1 and 2 (Kis = 27 and 6.9 μM, respectively).{38144} It is selective for SK1/2 over a panel of 140 human protein kinases at concentrations up to 25 μM. MP-A08 (15 μM) reduces generation of cellular sphingosine-1-phosphate (S1P; Item No. 62570) without inducing degradation of SK1 in Jurkat cells. It induces a 3.7-, 3.5-, and 5.8-fold increase in C-18 ceramide (Item No. 19556), C-20 ceramide (Item No. 10724), and C20:1-ceramide levels, respectively, and dose-dependently activates the apoptosis-associated p38 and JNK pathways in vitro. MP-A08 reduces proliferation of a variety of human cancer cell lines (EC50s = 8-44.9 μM). MP-A08 also reduces tumor vasculature, as determined by CD31 staining, and volume as well as S1P protein levels in A549 human lung adenocarcinoma xenografts in mice.

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SKU:21903 -

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MP-A08 – 25 mg

MP-A08 is an ATP-competitive inhibitor of sphingosine kinases (SKs) 1 and 2 (Kis = 27 and 6.9 μM, respectively).{38144} It is selective for SK1/2 over a panel of 140 human protein kinases at concentrations up to 25 μM. MP-A08 (15 μM) reduces generation of cellular sphingosine-1-phosphate (S1P; Item No. 62570) without inducing degradation of SK1 in Jurkat cells. It induces a 3.7-, 3.5-, and 5.8-fold increase in C-18 ceramide (Item No. 19556), C-20 ceramide (Item No. 10724), and C20:1-ceramide levels, respectively, and dose-dependently activates the apoptosis-associated p38 and JNK pathways in vitro. MP-A08 reduces proliferation of a variety of human cancer cell lines (EC50s = 8-44.9 μM). MP-A08 also reduces tumor vasculature, as determined by CD31 staining, and volume as well as S1P protein levels in A549 human lung adenocarcinoma xenografts in mice.

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SKU:21903 -

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MP-A08 – 5 mg

MP-A08 is an ATP-competitive inhibitor of sphingosine kinases (SKs) 1 and 2 (Kis = 27 and 6.9 μM, respectively).{38144} It is selective for SK1/2 over a panel of 140 human protein kinases at concentrations up to 25 μM. MP-A08 (15 μM) reduces generation of cellular sphingosine-1-phosphate (S1P; Item No. 62570) without inducing degradation of SK1 in Jurkat cells. It induces a 3.7-, 3.5-, and 5.8-fold increase in C-18 ceramide (Item No. 19556), C-20 ceramide (Item No. 10724), and C20:1-ceramide levels, respectively, and dose-dependently activates the apoptosis-associated p38 and JNK pathways in vitro. MP-A08 reduces proliferation of a variety of human cancer cell lines (EC50s = 8-44.9 μM). MP-A08 also reduces tumor vasculature, as determined by CD31 staining, and volume as well as S1P protein levels in A549 human lung adenocarcinoma xenografts in mice.

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SKU:21903 -

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MPA Assay Reagent – 2 g

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Cayman

SKU:700518 - 2 g

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MPC-3100 – 1 mg

MPC-3100 is an inhibitor of heat shock protein 90 (Hsp90; IC50 = 0.14 µM in a fluorescence polarization assay).{53052} It inhibits proliferation of a variety of cancer cell lines, including colon, prostate, ovarian, gastric, and breast cancer cells (IC50s = 0.2-0.55 µM), as well as MV4-11 leukemia, A549 non-small cell lung cancer (NSCLC), NCI H69 SCLC, and multidrug-resistant NCI/ADR-RES cells (IC50s = 0.25, 0.77, 0.15, and 4.3 µM, respectively). MPC-3100 induces degradation of the Hsp90 client proteins Akt and HER2 (IC50s = 0.1-0.5 µM) and a compensatory Hsp70 response in NCI N87, HCT116, and DU145 cell lysates. It also induces Hsp70 expression in the liver and tumor tissue and reduces tumor growth in an NCI N87 mouse xenograft model when administered at doses of 50 and 75 mg/kg. It induces tumor regression in the same model when administered at doses of 125 and 200 mg/kg.

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SKU:22496 -

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MPC-3100 – 10 mg

MPC-3100 is an inhibitor of heat shock protein 90 (Hsp90; IC50 = 0.14 µM in a fluorescence polarization assay).{53052} It inhibits proliferation of a variety of cancer cell lines, including colon, prostate, ovarian, gastric, and breast cancer cells (IC50s = 0.2-0.55 µM), as well as MV4-11 leukemia, A549 non-small cell lung cancer (NSCLC), NCI H69 SCLC, and multidrug-resistant NCI/ADR-RES cells (IC50s = 0.25, 0.77, 0.15, and 4.3 µM, respectively). MPC-3100 induces degradation of the Hsp90 client proteins Akt and HER2 (IC50s = 0.1-0.5 µM) and a compensatory Hsp70 response in NCI N87, HCT116, and DU145 cell lysates. It also induces Hsp70 expression in the liver and tumor tissue and reduces tumor growth in an NCI N87 mouse xenograft model when administered at doses of 50 and 75 mg/kg. It induces tumor regression in the same model when administered at doses of 125 and 200 mg/kg.

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SKU:22496 -

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MPC-3100 – 25 mg

MPC-3100 is an inhibitor of heat shock protein 90 (Hsp90; IC50 = 0.14 µM in a fluorescence polarization assay).{53052} It inhibits proliferation of a variety of cancer cell lines, including colon, prostate, ovarian, gastric, and breast cancer cells (IC50s = 0.2-0.55 µM), as well as MV4-11 leukemia, A549 non-small cell lung cancer (NSCLC), NCI H69 SCLC, and multidrug-resistant NCI/ADR-RES cells (IC50s = 0.25, 0.77, 0.15, and 4.3 µM, respectively). MPC-3100 induces degradation of the Hsp90 client proteins Akt and HER2 (IC50s = 0.1-0.5 µM) and a compensatory Hsp70 response in NCI N87, HCT116, and DU145 cell lysates. It also induces Hsp70 expression in the liver and tumor tissue and reduces tumor growth in an NCI N87 mouse xenograft model when administered at doses of 50 and 75 mg/kg. It induces tumor regression in the same model when administered at doses of 125 and 200 mg/kg.

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SKU:22496 -

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MPC-3100 – 5 mg

MPC-3100 is an inhibitor of heat shock protein 90 (Hsp90; IC50 = 0.14 µM in a fluorescence polarization assay).{53052} It inhibits proliferation of a variety of cancer cell lines, including colon, prostate, ovarian, gastric, and breast cancer cells (IC50s = 0.2-0.55 µM), as well as MV4-11 leukemia, A549 non-small cell lung cancer (NSCLC), NCI H69 SCLC, and multidrug-resistant NCI/ADR-RES cells (IC50s = 0.25, 0.77, 0.15, and 4.3 µM, respectively). MPC-3100 induces degradation of the Hsp90 client proteins Akt and HER2 (IC50s = 0.1-0.5 µM) and a compensatory Hsp70 response in NCI N87, HCT116, and DU145 cell lysates. It also induces Hsp70 expression in the liver and tumor tissue and reduces tumor growth in an NCI N87 mouse xenograft model when administered at doses of 50 and 75 mg/kg. It induces tumor regression in the same model when administered at doses of 125 and 200 mg/kg.

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SKU:22496 -

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MPEP (hydrochloride) – 10 mg

Glutamate, the major excitatory neurotransmitter in the brain, acts on both ionotropic and metabotropic glutamate receptors. Excessive metabotropic glutamate receptor (mGluR) transmission has been linked to epilepsy, ischemia, pain, anxiety, and depression. Eight subtypes (1-8) and multiple splice variants of the mGluR have been identified and grouped based on their pharmacological properties. Group I mGluRs (subtypes 1 and 5) activate the phosphatidyl inositol pathway, while Group II (2 and 3) and Group III (4, 6, 7 and 8) inhibit adenylyl cyclase. MPEP is a potent, highly selective non-competitive antagonist at the mGlu5a receptor subtype (IC50 = 36 nM) while having no agonist or antagonist activities at the mGlu1b receptor at concentrations up to 30 μM.{22822} MPEP is centrally active following systemic administration in vivo, inducing anxiolytic-like effects in rodent models of anxiety and depression when administered at 1-30 mg/kg.{22822} MPEP has also been reported as a positive allosteric modulator of mGluR4 at μM concentrations.{22823}

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MPEP (hydrochloride) – 25 mg

Glutamate, the major excitatory neurotransmitter in the brain, acts on both ionotropic and metabotropic glutamate receptors. Excessive metabotropic glutamate receptor (mGluR) transmission has been linked to epilepsy, ischemia, pain, anxiety, and depression. Eight subtypes (1-8) and multiple splice variants of the mGluR have been identified and grouped based on their pharmacological properties. Group I mGluRs (subtypes 1 and 5) activate the phosphatidyl inositol pathway, while Group II (2 and 3) and Group III (4, 6, 7 and 8) inhibit adenylyl cyclase. MPEP is a potent, highly selective non-competitive antagonist at the mGlu5a receptor subtype (IC50 = 36 nM) while having no agonist or antagonist activities at the mGlu1b receptor at concentrations up to 30 μM.{22822} MPEP is centrally active following systemic administration in vivo, inducing anxiolytic-like effects in rodent models of anxiety and depression when administered at 1-30 mg/kg.{22822} MPEP has also been reported as a positive allosteric modulator of mGluR4 at μM concentrations.{22823}

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