Cayman
Showing 30001–30150 of 45550 results
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MLS-1547 is a G protein-biased agonist of dopamine D2 receptors (EC50 = 0.37 μM in a calcium mobilization assay).{42964} It inhibits forskolin-induced cAMP accumulation in CHO cells expressing human D2 receptors (EC50 = 0.26 μM) but is inactive in β-arrestin recruitment assays. MLS-1547 antagonizes dopamine-induced β-arrestin recruitment in cell-based assays with IC50 values ranging from 3.8 to 9.9 μM.{42964} It is also an inhibitor of type II secretion in Gram-negative bacteria.{42965} MLS-1547 inhibits secretion of phospholipase C (PlcH/N) and the virulence factor elastase (LasB) from P. aeruginosa (IC50s = 15 and 13 μM, respectively) and inhibits B. pseudomallei protease secretion by 90.8% when used at a concentration of 25 μM.
Brand:CaymanSKU:27648 - 1 mgAvailable on backorder
MLS-1547 is a G protein-biased agonist of dopamine D2 receptors (EC50 = 0.37 μM in a calcium mobilization assay).{42964} It inhibits forskolin-induced cAMP accumulation in CHO cells expressing human D2 receptors (EC50 = 0.26 μM) but is inactive in β-arrestin recruitment assays. MLS-1547 antagonizes dopamine-induced β-arrestin recruitment in cell-based assays with IC50 values ranging from 3.8 to 9.9 μM.{42964} It is also an inhibitor of type II secretion in Gram-negative bacteria.{42965} MLS-1547 inhibits secretion of phospholipase C (PlcH/N) and the virulence factor elastase (LasB) from P. aeruginosa (IC50s = 15 and 13 μM, respectively) and inhibits B. pseudomallei protease secretion by 90.8% when used at a concentration of 25 μM.
Brand:CaymanSKU:27648 - 10 mgAvailable on backorder
MLS-1547 is a G protein-biased agonist of dopamine D2 receptors (EC50 = 0.37 μM in a calcium mobilization assay).{42964} It inhibits forskolin-induced cAMP accumulation in CHO cells expressing human D2 receptors (EC50 = 0.26 μM) but is inactive in β-arrestin recruitment assays. MLS-1547 antagonizes dopamine-induced β-arrestin recruitment in cell-based assays with IC50 values ranging from 3.8 to 9.9 μM.{42964} It is also an inhibitor of type II secretion in Gram-negative bacteria.{42965} MLS-1547 inhibits secretion of phospholipase C (PlcH/N) and the virulence factor elastase (LasB) from P. aeruginosa (IC50s = 15 and 13 μM, respectively) and inhibits B. pseudomallei protease secretion by 90.8% when used at a concentration of 25 μM.
Brand:CaymanSKU:27648 - 25 mgAvailable on backorder
MLS-1547 is a G protein-biased agonist of dopamine D2 receptors (EC50 = 0.37 μM in a calcium mobilization assay).{42964} It inhibits forskolin-induced cAMP accumulation in CHO cells expressing human D2 receptors (EC50 = 0.26 μM) but is inactive in β-arrestin recruitment assays. MLS-1547 antagonizes dopamine-induced β-arrestin recruitment in cell-based assays with IC50 values ranging from 3.8 to 9.9 μM.{42964} It is also an inhibitor of type II secretion in Gram-negative bacteria.{42965} MLS-1547 inhibits secretion of phospholipase C (PlcH/N) and the virulence factor elastase (LasB) from P. aeruginosa (IC50s = 15 and 13 μM, respectively) and inhibits B. pseudomallei protease secretion by 90.8% when used at a concentration of 25 μM.
Brand:CaymanSKU:27648 - 5 mgAvailable on backorder
The Rho family of GTPases regulates diverse signal transduction pathways. One member, the cell division control protein 42 homolog (Cdc42), is involved in filopodia function, cell polarity, cell cycling, and other processes.{24682} MLS-573151 is a specific, cell permeable inhibitor of Cdc42 (IC50 = 2 μM).{24681} It has no effect on other GTPases, including the related Rho family members RhoA, Rac1, and Rac2.{24681} It acts by blocking the binding of GTP to Cdc42.{24681}
Brand:CaymanSKU:- The Rho family of GTPases regulates diverse signal transduction pathways. One member, the cell division control protein 42 homolog (Cdc42), is involved in filopodia function, cell polarity, cell cycling, and other processes.{24682} MLS-573151 is a specific, cell permeable inhibitor of Cdc42 (IC50 = 2 μM).{24681} It has no effect on other GTPases, including the related Rho family members RhoA, Rac1, and Rac2.{24681} It acts by blocking the binding of GTP to Cdc42.{24681}
Brand:CaymanSKU:- The Rho family of GTPases regulates diverse signal transduction pathways. One member, the cell division control protein 42 homolog (Cdc42), is involved in filopodia function, cell polarity, cell cycling, and other processes.{24682} MLS-573151 is a specific, cell permeable inhibitor of Cdc42 (IC50 = 2 μM).{24681} It has no effect on other GTPases, including the related Rho family members RhoA, Rac1, and Rac2.{24681} It acts by blocking the binding of GTP to Cdc42.{24681}
Brand:CaymanSKU:- The Rho family of GTPases regulates diverse signal transduction pathways. One member, the cell division control protein 42 homolog (Cdc42), is involved in filopodia function, cell polarity, cell cycling, and other processes.{24682} MLS-573151 is a specific, cell permeable inhibitor of Cdc42 (IC50 = 2 μM).{24681} It has no effect on other GTPases, including the related Rho family members RhoA, Rac1, and Rac2.{24681} It acts by blocking the binding of GTP to Cdc42.{24681}
Brand:CaymanSKU:-
WD-repeat protein 5 (WDR5) is a scaffold protein commonly involved in the formation of nucleosome-modifying protein complexes with histones.{22296} It serves as a component of a mixed-lineage leukemia (MLL) methyltransferase complex that targets histone 3 at lysine 4 to upregulate transcription.{20287} MM-102 is a potent WDR5/MLL interaction inhibitor (IC50 = 2.4 nM).{28950} It has been shown to block MLL1 methyltransferase activity, reducing the expression of HoxA9 and Meis-1 genes, which are both critical MLL1 target genes in MLL1 fusion protein-mediated leukemogenesis.{28950} MM-102 can also inhibit cell growth and induce apoptosis in leukemia cells harboring MLL1 fusion proteins.{28950}
Brand:CaymanSKU:-Available on backorder
WD-repeat protein 5 (WDR5) is a scaffold protein commonly involved in the formation of nucleosome-modifying protein complexes with histones.{22296} It serves as a component of a mixed-lineage leukemia (MLL) methyltransferase complex that targets histone 3 at lysine 4 to upregulate transcription.{20287} MM-102 is a potent WDR5/MLL interaction inhibitor (IC50 = 2.4 nM).{28950} It has been shown to block MLL1 methyltransferase activity, reducing the expression of HoxA9 and Meis-1 genes, which are both critical MLL1 target genes in MLL1 fusion protein-mediated leukemogenesis.{28950} MM-102 can also inhibit cell growth and induce apoptosis in leukemia cells harboring MLL1 fusion proteins.{28950}
Brand:CaymanSKU:-Available on backorder
WD-repeat protein 5 (WDR5) is a scaffold protein commonly involved in the formation of nucleosome-modifying protein complexes with histones.{22296} It serves as a component of a mixed-lineage leukemia (MLL) methyltransferase complex that targets histone 3 at lysine 4 to upregulate transcription.{20287} MM-102 is a potent WDR5/MLL interaction inhibitor (IC50 = 2.4 nM).{28950} It has been shown to block MLL1 methyltransferase activity, reducing the expression of HoxA9 and Meis-1 genes, which are both critical MLL1 target genes in MLL1 fusion protein-mediated leukemogenesis.{28950} MM-102 can also inhibit cell growth and induce apoptosis in leukemia cells harboring MLL1 fusion proteins.{28950}
Brand:CaymanSKU:-Available on backorder
WD-repeat protein 5 (WDR5) is a scaffold protein commonly involved in the formation of nucleosome-modifying protein complexes with histones.{22296} It serves as a component of a mixed-lineage leukemia (MLL) methyltransferase complex that targets histone 3 at lysine 4 to upregulate transcription.{20287} MM-102 is a potent WDR5/MLL interaction inhibitor (IC50 = 2.4 nM).{28950} It has been shown to block MLL1 methyltransferase activity, reducing the expression of HoxA9 and Meis-1 genes, which are both critical MLL1 target genes in MLL1 fusion protein-mediated leukemogenesis.{28950} MM-102 can also inhibit cell growth and induce apoptosis in leukemia cells harboring MLL1 fusion proteins.{28950}
Brand:CaymanSKU:-Available on backorder
MM-11253 is a synthetic, conformationally restricted retinoid that acts as a selective antagonist of retinoic acid receptor γ (RARγ).{34220} It dose-dependently blocks the ability of RARγ-selective agonists, but not retinoic acid (all-trans retinoic acid; Item No. 11017), to inhibit the growth of oral squamous cell carcinoma cells in vitro.{34220}
Brand:CaymanSKU:21800 -Out of stock
MM-11253 is a synthetic, conformationally restricted retinoid that acts as a selective antagonist of retinoic acid receptor γ (RARγ).{34220} It dose-dependently blocks the ability of RARγ-selective agonists, but not retinoic acid (all-trans retinoic acid; Item No. 11017), to inhibit the growth of oral squamous cell carcinoma cells in vitro.{34220}
Brand:CaymanSKU:21800 -Out of stock
MM-11253 is a synthetic, conformationally restricted retinoid that acts as a selective antagonist of retinoic acid receptor γ (RARγ).{34220} It dose-dependently blocks the ability of RARγ-selective agonists, but not retinoic acid (all-trans retinoic acid; Item No. 11017), to inhibit the growth of oral squamous cell carcinoma cells in vitro.{34220}
Brand:CaymanSKU:21800 -Out of stock
MM-11253 is a synthetic, conformationally restricted retinoid that acts as a selective antagonist of retinoic acid receptor γ (RARγ).{34220} It dose-dependently blocks the ability of RARγ-selective agonists, but not retinoic acid (all-trans retinoic acid; Item No. 11017), to inhibit the growth of oral squamous cell carcinoma cells in vitro.{34220}
Brand:CaymanSKU:21800 -Out of stock
MM-206 is an inhibitor of STAT3 (IC50 = 1.16 µM in an SPR-based competitive assay).{38611} It inhibits STAT3 phosphorylation induced by granulocyte colony-stimulating factor (G-CSF) in HL-60, Kasumi-1, and MOLM-13 acute myeloid leukemia (AML) cells (IC50s = 0.8, 1.9, and 1.1 µM, respectively). MM-206 induces apoptosis more potently in AML cell lines and patient-derived primary AML tumor cells than in acute lymphoblastic leukemia cells, which do not have upregulated STAT3 activity. It also slows disease progression and improves survival in an AML mouse xenograft model when administered at a dose of 30 mg/kg per day.
Brand:CaymanSKU:22032 -Out of stock
MM-206 is an inhibitor of STAT3 (IC50 = 1.16 µM in an SPR-based competitive assay).{38611} It inhibits STAT3 phosphorylation induced by granulocyte colony-stimulating factor (G-CSF) in HL-60, Kasumi-1, and MOLM-13 acute myeloid leukemia (AML) cells (IC50s = 0.8, 1.9, and 1.1 µM, respectively). MM-206 induces apoptosis more potently in AML cell lines and patient-derived primary AML tumor cells than in acute lymphoblastic leukemia cells, which do not have upregulated STAT3 activity. It also slows disease progression and improves survival in an AML mouse xenograft model when administered at a dose of 30 mg/kg per day.
Brand:CaymanSKU:22032 -Out of stock
MM-206 is an inhibitor of STAT3 (IC50 = 1.16 µM in an SPR-based competitive assay).{38611} It inhibits STAT3 phosphorylation induced by granulocyte colony-stimulating factor (G-CSF) in HL-60, Kasumi-1, and MOLM-13 acute myeloid leukemia (AML) cells (IC50s = 0.8, 1.9, and 1.1 µM, respectively). MM-206 induces apoptosis more potently in AML cell lines and patient-derived primary AML tumor cells than in acute lymphoblastic leukemia cells, which do not have upregulated STAT3 activity. It also slows disease progression and improves survival in an AML mouse xenograft model when administered at a dose of 30 mg/kg per day.
Brand:CaymanSKU:22032 -Out of stock
MMAF is an auristatin with anticancer activity.{37315} It is cytotoxic to Karpas 299 anaplastic large cell lymphoma, H3396 breast carcinoma, and 786-O and Caki-1 renal carcinoma cells in vitro (IC50s = 119, 105, 257, and 200 nM, respectively), as well as in a panel of 11 lymphoma cell lines (IC50s = 34.8-164 nM).
Brand:CaymanSKU:30197 - 10 mgAvailable on backorder
MMAF is an auristatin with anticancer activity.{37315} It is cytotoxic to Karpas 299 anaplastic large cell lymphoma, H3396 breast carcinoma, and 786-O and Caki-1 renal carcinoma cells in vitro (IC50s = 119, 105, 257, and 200 nM, respectively), as well as in a panel of 11 lymphoma cell lines (IC50s = 34.8-164 nM).
Brand:CaymanSKU:30197 - 25 mgAvailable on backorder
MMAF is an auristatin with anticancer activity.{37315} It is cytotoxic to Karpas 299 anaplastic large cell lymphoma, H3396 breast carcinoma, and 786-O and Caki-1 renal carcinoma cells in vitro (IC50s = 119, 105, 257, and 200 nM, respectively), as well as in a panel of 11 lymphoma cell lines (IC50s = 34.8-164 nM).
Brand:CaymanSKU:30197 - 5 mgAvailable on backorder
MMAF is an auristatin with anticancer activity.{37315} It is cytotoxic to Karpas 299 anaplastic large cell lymphoma, H3396 breast carcinoma, and 786-O and Caki-1 renal carcinoma cells in vitro (IC50s = 119, 105, 257, and 200 nM, respectively), as well as in a panel of 11 lymphoma cell lines (IC50s = 34.8-164 nM).
Brand:CaymanSKU:30197 - 50 mgAvailable on backorder
MMAI is a psychoactive aminoindan which can be found in recreational drug mixtures.{22283} It potently inhibits serotonin uptake (IC50 = 212 nM) and stimulates its release without inducing the neurotoxicity induced by 3,4-methylenedioxy methamphetamine and similar compounds.{22282,21930} This product is intended for forensic and research applications.
Brand:CaymanSKU:- MMAI is a psychoactive aminoindan which can be found in recreational drug mixtures.{22283} It potently inhibits serotonin uptake (IC50 = 212 nM) and stimulates its release without inducing the neurotoxicity induced by 3,4-methylenedioxy methamphetamine and similar compounds.{22282,21930} This product is intended for forensic and research applications.
Brand:CaymanSKU:- MMAI is a psychoactive aminoindan which can be found in recreational drug mixtures.{22283} It potently inhibits serotonin uptake (IC50 = 212 nM) and stimulates its release without inducing the neurotoxicity induced by 3,4-methylenedioxy methamphetamine and similar compounds.{22282,21930} This product is intended for forensic and research applications.
Brand:CaymanSKU:-
MMB-FUBICA (Item No. 20182) is an analytical reference standard that is structurally classified as a synthetic cannabinoid. The physiological and toxicological properties of this compound are not known. This product is intended for research and forensic applications.
Brand:CaymanSKU:20182 -Available on backorder
MMB-FUBICA (Item No. 20182) is an analytical reference standard that is structurally classified as a synthetic cannabinoid. The physiological and toxicological properties of this compound are not known. This product is intended for research and forensic applications.
Brand:CaymanSKU:20182 -Available on backorder
MMB018 is a synthetic cannabinoid (CB) that contains the key 1-pentyl-indole structure found in potent agonists of the central cannabinoid (CB1) receptor, like JWH 018 (Item No. 10900). The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research applications.
Brand:CaymanSKU:- MMB018 is a synthetic cannabinoid (CB) that contains the key 1-pentyl-indole structure found in potent agonists of the central cannabinoid (CB1) receptor, like JWH 018 (Item No. 10900). The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research applications.
Brand:CaymanSKU:- MMB018 is a synthetic cannabinoid (CB) that contains the key 1-pentyl-indole structure found in potent agonists of the central cannabinoid (CB1) receptor, like JWH 018 (Item No. 10900). The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research applications.
Brand:CaymanSKU:-
MMB2201 is a synthetic cannabinoid that combines methyl valinate with the 1-(5-fluoropentyl)-indole-3-keto subgroup of AM2201 (Item No. 10707). The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research applications.
Brand:CaymanSKU:- MMB2201 is a synthetic cannabinoid that combines methyl valinate with the 1-(5-fluoropentyl)-indole-3-keto subgroup of AM2201 (Item No. 10707). The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research applications.
Brand:CaymanSKU:- MMB2201 is a synthetic cannabinoid that combines methyl valinate with the 1-(5-fluoropentyl)-indole-3-keto subgroup of AM2201 (Item No. 10707). The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research applications.
Brand:CaymanSKU:-
MMDA-2 (hydrochloride) (Item No. 17659) is an analytical reference standard that is classified as an amphetamine. It only weakly induces the release of serotonin or dopamine from rat brain synaptosomes and does not produce amphetamine-like responses in drug discrimination studies in rats.{25970,30481} Instead, MMDA-2 is thought to act as a 5-HT2A agonist, which may account for hallucinogenic effects.{30480} This product is intended for forensic and research applications.
Brand:CaymanSKU:-Available on backorder
MMDA-2 (hydrochloride) (Item No. 17659) is an analytical reference standard that is classified as an amphetamine. It only weakly induces the release of serotonin or dopamine from rat brain synaptosomes and does not produce amphetamine-like responses in drug discrimination studies in rats.{25970,30481} Instead, MMDA-2 is thought to act as a 5-HT2A agonist, which may account for hallucinogenic effects.{30480} This product is intended for forensic and research applications.
Brand:CaymanSKU:-Available on backorder
MMDA-2 (hydrochloride) (Item No. 17659) is an analytical reference standard that is classified as an amphetamine. It only weakly induces the release of serotonin or dopamine from rat brain synaptosomes and does not produce amphetamine-like responses in drug discrimination studies in rats.{25970,30481} Instead, MMDA-2 is thought to act as a 5-HT2A agonist, which may account for hallucinogenic effects.{30480} This product is intended for forensic and research applications.
Brand:CaymanSKU:-Available on backorder
MMDPPA (Item No. 31580) is an analytical reference standard categorized as an amphetamine. MMDPPA is a precursor in the synthesis of MDA.{28110} This product is intended for research and forensic applications.
Brand:CaymanSKU:31580 - 1 mgAvailable on backorder
MMDPPA (Item No. 31580) is an analytical reference standard categorized as an amphetamine. MMDPPA is a precursor in the synthesis of MDA.{28110} This product is intended for research and forensic applications.
Brand:CaymanSKU:31580 - 5 mgAvailable on backorder
MMDPPO (Item No. 31579) is an analytical reference standard categorized as an amphetamine. MMDPPO is an intermediate in the synthesis of (±)-MDA (Item Nos. ISO60189 | 11554).{28809} This product is intended for research and forensic applications.
Brand:CaymanSKU:31579 - 1 mgAvailable on backorder
MMDPPO (Item No. 31579) is an analytical reference standard categorized as an amphetamine. MMDPPO is an intermediate in the synthesis of (±)-MDA (Item Nos. ISO60189 | 11554).{28809} This product is intended for research and forensic applications.
Brand:CaymanSKU:31579 - 5 mgAvailable on backorder
MMG-0358 is an inhibitor of indolamine 2,3-dioxygenase 1 (IDO1; IC50s = 2 and 80 nM for the mouse and human enzyme, respectively).{54011,50812} It is selective for IDO1 over tryptophan 2,3-dioxygenase (TDO; IC50s = >100 µM for mouse and human TDO).{54011}
Brand:CaymanSKU:29828 - 1 mgAvailable on backorder
MMG-0358 is an inhibitor of indolamine 2,3-dioxygenase 1 (IDO1; IC50s = 2 and 80 nM for the mouse and human enzyme, respectively).{54011,50812} It is selective for IDO1 over tryptophan 2,3-dioxygenase (TDO; IC50s = >100 µM for mouse and human TDO).{54011}
Brand:CaymanSKU:29828 - 10 mgAvailable on backorder
MMG-0358 is an inhibitor of indolamine 2,3-dioxygenase 1 (IDO1; IC50s = 2 and 80 nM for the mouse and human enzyme, respectively).{54011,50812} It is selective for IDO1 over tryptophan 2,3-dioxygenase (TDO; IC50s = >100 µM for mouse and human TDO).{54011}
Brand:CaymanSKU:29828 - 5 mgAvailable on backorder
Matrix metalloproteinases (MMPs) belong to a family of proteases that play a crucial role in tissue remodeling and repair by degrading extracellular matrix proteins to enable cell migration.{16569} MMP Inhibitor II is a reversible, broad-range inhibitor of MMPs. It has been reported to inhibit MMP-1 (IC50 = 24 nM), MMP-3 (IC50 = 18.4 nM), MMP-7 (IC50 = 30 nM), and MMP-9 (IC50 = 2.7 nM).{25901}
Brand:CaymanSKU:- Matrix metalloproteinases (MMPs) belong to a family of proteases that play a crucial role in tissue remodeling and repair by degrading extracellular matrix proteins to enable cell migration.{16569} MMP Inhibitor II is a reversible, broad-range inhibitor of MMPs. It has been reported to inhibit MMP-1 (IC50 = 24 nM), MMP-3 (IC50 = 18.4 nM), MMP-7 (IC50 = 30 nM), and MMP-9 (IC50 = 2.7 nM).{25901}
Brand:CaymanSKU:- Matrix metalloproteinases (MMPs) belong to a family of proteases that play a crucial role in tissue remodeling and repair by degrading extracellular matrix proteins to enable cell migration.{16569} MMP Inhibitor II is a reversible, broad-range inhibitor of MMPs. It has been reported to inhibit MMP-1 (IC50 = 24 nM), MMP-3 (IC50 = 18.4 nM), MMP-7 (IC50 = 30 nM), and MMP-9 (IC50 = 2.7 nM).{25901}
Brand:CaymanSKU:-
MMP-13 Inhibitor is a pyrimidine dicarboxamide that inhibits matrix metalloproteinase-13 (MMP-13, also known as collagenase-3) with an IC50 value of 8 nM.{32009,32010} MMP-13 Inhibitor binds to pockets that are unique to MMP-13, rather than the catalytic zinc, and thus is specific for MMP-13 over other MMPs.{32009,32010} MMP-13 Inhibitor blocks osterix-dependent calcification of matrices in limb bud cells during endochondral ossification.{32011}
Brand:CaymanSKU:-Available on backorder
MMP-13 Inhibitor is a pyrimidine dicarboxamide that inhibits matrix metalloproteinase-13 (MMP-13, also known as collagenase-3) with an IC50 value of 8 nM.{32009,32010} MMP-13 Inhibitor binds to pockets that are unique to MMP-13, rather than the catalytic zinc, and thus is specific for MMP-13 over other MMPs.{32009,32010} MMP-13 Inhibitor blocks osterix-dependent calcification of matrices in limb bud cells during endochondral ossification.{32011}
Brand:CaymanSKU:-Available on backorder
MMP-13 Inhibitor is a pyrimidine dicarboxamide that inhibits matrix metalloproteinase-13 (MMP-13, also known as collagenase-3) with an IC50 value of 8 nM.{32009,32010} MMP-13 Inhibitor binds to pockets that are unique to MMP-13, rather than the catalytic zinc, and thus is specific for MMP-13 over other MMPs.{32009,32010} MMP-13 Inhibitor blocks osterix-dependent calcification of matrices in limb bud cells during endochondral ossification.{32011}
Brand:CaymanSKU:-Available on backorder
MMP-2 Inhibitor I is a hydroxamate-based, long-chain fatty acid that acts as a reversible inhibitor of matrix metalloproteinase (MMP)-2 (Ki = 1.6 µM), a protein implicated in the pathological breakdown of extracellular matrix proteins.{31343} Increased levels of MMP-2 are associated with tumor invasion and metastasis. This compound has been shown to attenuate cancer cell migration.{31344} It has also been used to preserve blood-brain barrier function in a rat model of pneumococcal meningitis.{31342}
Brand:CaymanSKU:19644 -Available on backorder
MMP-2 Inhibitor I is a hydroxamate-based, long-chain fatty acid that acts as a reversible inhibitor of matrix metalloproteinase (MMP)-2 (Ki = 1.6 µM), a protein implicated in the pathological breakdown of extracellular matrix proteins.{31343} Increased levels of MMP-2 are associated with tumor invasion and metastasis. This compound has been shown to attenuate cancer cell migration.{31344} It has also been used to preserve blood-brain barrier function in a rat model of pneumococcal meningitis.{31342}
Brand:CaymanSKU:19644 -Available on backorder
MMP-2 Inhibitor II is an oxirane p-sulfonamido analog of SB-3CT (Item No. 16337) that irreversibly inhibits matrix metalloproteinase-2 (MMP-2; Ki = 2.4 µM).{30467} It less potently inhibits MMP-1 and -7 (Kis = 45 and 379 µM, respectively) and does not inhibit MMP-3, -7, or -9.{30467} MMP-2 Inhibitor II, at 5 µM, attenuates glucose-induced MMP-2 activity and expression, as well as subsequent apoptosis, in retinal endothelial cells.{30468} It has also been used to examine the role of MMP-2 in rheumatoid synovial fibroblast survival, inflammation, and cartilage degradation.{30469}
Brand:CaymanSKU:-Out of stock
MMP-2 Inhibitor II is an oxirane p-sulfonamido analog of SB-3CT (Item No. 16337) that irreversibly inhibits matrix metalloproteinase-2 (MMP-2; Ki = 2.4 µM).{30467} It less potently inhibits MMP-1 and -7 (Kis = 45 and 379 µM, respectively) and does not inhibit MMP-3, -7, or -9.{30467} MMP-2 Inhibitor II, at 5 µM, attenuates glucose-induced MMP-2 activity and expression, as well as subsequent apoptosis, in retinal endothelial cells.{30468} It has also been used to examine the role of MMP-2 in rheumatoid synovial fibroblast survival, inflammation, and cartilage degradation.{30469}
Brand:CaymanSKU:-Out of stock
MMP-2 Inhibitor II is an oxirane p-sulfonamido analog of SB-3CT (Item No. 16337) that irreversibly inhibits matrix metalloproteinase-2 (MMP-2; Ki = 2.4 µM).{30467} It less potently inhibits MMP-1 and -7 (Kis = 45 and 379 µM, respectively) and does not inhibit MMP-3, -7, or -9.{30467} MMP-2 Inhibitor II, at 5 µM, attenuates glucose-induced MMP-2 activity and expression, as well as subsequent apoptosis, in retinal endothelial cells.{30468} It has also been used to examine the role of MMP-2 in rheumatoid synovial fibroblast survival, inflammation, and cartilage degradation.{30469}
Brand:CaymanSKU:-Out of stock
MMP-2/MMP-9 inhibitor I is a potent inhibitor of matrix metalloproteinase-2 (MMP-2) and MMP-9 (IC50s = 310 and 240 nM, respectively).{32343} It acts by binding zinc at the active site of these MMPs. MMP-2/MMP-9 inhibitor I is active in vivo as well as in vitro and blocks MMP-2/MMP-9-dependent invasion, tumor growth, and metastasis in both cell culture and mouse tumor models.{32343} This compound has been used to elucidate the roles of MMP-2 and MMP-9 in diverse systems, including mammary epithelial cell transformation, neuronal dysfunction, lymphocyte recruitment, and progressive hereditary kidney disease.{32340,32341,32342,32344}
Brand:CaymanSKU:20315 -Available on backorder
MMP-2/MMP-9 inhibitor II is a dual inhibitor of matrix metalloproteinase-2 (MMP-2) and MMP-9 (IC50s = 17 and 30 nM, respectively).{32343} In mice, it suppresses lung colonization of Lewis lung carcinoma cells and inhibits tumor-induced angiogenesis, tumor growth, and liver metastasis.{32343},{37366}
Brand:CaymanSKU:24314 - 1 mgAvailable on backorder
MMP-2/MMP-9 inhibitor II is a dual inhibitor of matrix metalloproteinase-2 (MMP-2) and MMP-9 (IC50s = 17 and 30 nM, respectively).{32343} In mice, it suppresses lung colonization of Lewis lung carcinoma cells and inhibits tumor-induced angiogenesis, tumor growth, and liver metastasis.{32343},{37366}
Brand:CaymanSKU:24314 - 500 µgAvailable on backorder
MMP-3 inhibitor is a peptide inhibitor of matrix metalloproteinase-3 (MMP-3) with a Ki value of 95 nM.{41487}
Brand:CaymanSKU:24315 - 1 mgAvailable on backorder
MMP-3 inhibitor is a peptide inhibitor of matrix metalloproteinase-3 (MMP-3) with a Ki value of 95 nM.{41487}
Brand:CaymanSKU:24315 - 5 mgAvailable on backorder
Matrix metalloproteinases (MMPs) belong to a family of proteases that play a crucial role in tissue remodeling and repair by degrading extracellular matrix proteins to enable cell migration.{16569} MMP-3 (also known as stromelysin-1) is thought to play a role in the vascular remodeling that occurs during aneurysm formation and may also be involved in wound repair, progression of atherosclerosis, and tumor initiation.{28397} MMP-3 inhibitor VIII is a cell permeable sulfonamide-based hydroxamic acid that binds to the active site of MMP-3 (Ki = 23 nM) and prevents its activity.{28399} This compound has also been shown to inhibit mouse macrophage metalloelastase MME/MMP-12 with an IC50 value of 13 nM.{28398}
Brand:CaymanSKU:-Out of stock
Matrix metalloproteinases (MMPs) belong to a family of proteases that play a crucial role in tissue remodeling and repair by degrading extracellular matrix proteins to enable cell migration.{16569} MMP-3 (also known as stromelysin-1) is thought to play a role in the vascular remodeling that occurs during aneurysm formation and may also be involved in wound repair, progression of atherosclerosis, and tumor initiation.{28397} MMP-3 inhibitor VIII is a cell permeable sulfonamide-based hydroxamic acid that binds to the active site of MMP-3 (Ki = 23 nM) and prevents its activity.{28399} This compound has also been shown to inhibit mouse macrophage metalloelastase MME/MMP-12 with an IC50 value of 13 nM.{28398}
Brand:CaymanSKU:-Out of stock
Matrix metalloproteinases (MMPs) belong to a family of proteases that play a crucial role in tissue remodeling and repair by degrading extracellular matrix proteins to enable cell migration.{16569} MMP-3 (also known as stromelysin-1) is thought to play a role in the vascular remodeling that occurs during aneurysm formation and may also be involved in wound repair, progression of atherosclerosis, and tumor initiation.{28397} MMP-3 inhibitor VIII is a cell permeable sulfonamide-based hydroxamic acid that binds to the active site of MMP-3 (Ki = 23 nM) and prevents its activity.{28399} This compound has also been shown to inhibit mouse macrophage metalloelastase MME/MMP-12 with an IC50 value of 13 nM.{28398}
Brand:CaymanSKU:-Out of stock
MMP-8 Inhibitor I is a selective inhibitor of the neutrophil collagenase matrix metalloproteinase-8 (MMP-8) with an IC50 value of 4 nM.{34599} This inhibitor does not target the activities of other MMPs in vitro.{34587,34589} MMP-8 cleaves interstitial collagens and has exhibited activity in atherosclerotic plaques, angiogenesis, and stem cell mobilization.{34585} Additionally, MMP-8 expression is observed in normal mammary epithelial cells, whereas a loss of expression is observed in human ductal carcinoma in situ and the deletion of MMP-8 accelerates tumor onset in a mouse model of aggressive breast cancer.{34586,34590}
Brand:CaymanSKU:21852 -Out of stock
MMP-9 inhibitor I is an inhibitor of matrix metalloproteinase-9 (MMP-9) that is selective over MMP-1 and MMP-13 (IC50s = 5, 1,050, and 113 nM, respectively).{25729} It also decreases the activity of TNF-α converting enzyme (TACE) in a dose-dependent manner (IC50 = 0.54 µM).{36445} MMP-9 inhibitor I decreases TNF-α secretion stimulated by LPS in BV-2 microglial cells when used at concentrations of 50 and 100 µM.
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MMP-9/MMP-13 inhibitor I is a cell-permeable inhibitor of matrix metalloproteinases (MMPs) that most potently inhibits MMP-9 and MMP-13 (IC50s = 0.9 nM for both).{33201} It less effectively inhibits MMP-1, MMP-3, and MMP-7 (IC50s = 43, 23, and 920 nM, respectively).{33201} MMP-9/MMP-13 inhibitor I has been used to elucidate the roles of MMPs in biological systems, including tumor cell invasion and pathogenesis of P. falciparum.{33202,33203,33204}
Brand:CaymanSKU:21265 -Out of stock
MMP-9/MMP-13 inhibitor I is a cell-permeable inhibitor of matrix metalloproteinases (MMPs) that most potently inhibits MMP-9 and MMP-13 (IC50s = 0.9 nM for both).{33201} It less effectively inhibits MMP-1, MMP-3, and MMP-7 (IC50s = 43, 23, and 920 nM, respectively).{33201} MMP-9/MMP-13 inhibitor I has been used to elucidate the roles of MMPs in biological systems, including tumor cell invasion and pathogenesis of P. falciparum.{33202,33203,33204}
Brand:CaymanSKU:21265 -Out of stock
MMPIP is a reversible allosteric antagonist of the metabotropic glutamate receptor 7 (mGluR7) that blocks agonist-induced calcium mobilization (IC50 = 26 nM).{30427,30425} It does not affect other mGlu receptors. The modulation of mGluR7 by MMPIP is context dependent, in that it is not observed in all known mGluR7 signaling pathways.{30425} MMPIP has been used to investigate the role of mGluR7 in cocaine-mediated reward signaling, attention and impulse control, and cognitive behavior in mice and rats.{30424,30422,30426} MMPIP also reversibly inhibits constitutive activity of mGluR7 in sympathetic neurons from the rat superior cervical ganglion.{30423}
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MMPIP is a reversible allosteric antagonist of the metabotropic glutamate receptor 7 (mGluR7) that blocks agonist-induced calcium mobilization (IC50 = 26 nM).{30427,30425} It does not affect other mGlu receptors. The modulation of mGluR7 by MMPIP is context dependent, in that it is not observed in all known mGluR7 signaling pathways.{30425} MMPIP has been used to investigate the role of mGluR7 in cocaine-mediated reward signaling, attention and impulse control, and cognitive behavior in mice and rats.{30424,30422,30426} MMPIP also reversibly inhibits constitutive activity of mGluR7 in sympathetic neurons from the rat superior cervical ganglion.{30423}
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MMPIP is a reversible allosteric antagonist of the metabotropic glutamate receptor 7 (mGluR7) that blocks agonist-induced calcium mobilization (IC50 = 26 nM).{30427,30425} It does not affect other mGlu receptors. The modulation of mGluR7 by MMPIP is context dependent, in that it is not observed in all known mGluR7 signaling pathways.{30425} MMPIP has been used to investigate the role of mGluR7 in cocaine-mediated reward signaling, attention and impulse control, and cognitive behavior in mice and rats.{30424,30422,30426} MMPIP also reversibly inhibits constitutive activity of mGluR7 in sympathetic neurons from the rat superior cervical ganglion.{30423}
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Antigen: human Mn SOD • Host: rabbit • Cross Reactivity: (+) human, rat, mouse, bovine, canine, chicken, gerbil, guinea pig, porcine, hamster, monkey, rabbit, ovine, and Xenopus Mn SOD • Application(s): IHC, IP, and WB • SOD2 is a manganese-containing enzyme in the mitochondrial matrix that catalyzes the dismutation of the superoxide radical O2- to O2 and H2O2.
Brand:CaymanSKU:10011390- 100 µl Superoxide dismutase (SOD) is an endogenously produced intracellular enzyme present in almost every cell in the body.{15491} It catalyzes the dismutation of the superoxide radical O2- to O2 and H2O2.{15490,15493} There are two main types of SOD in mammalian cells. One form, SOD1, contains Cu and Zn ions as a homodimer and exists in the cytoplasm. The two subunits of 16 kDa each are linked by two cystines forming an intra-subunit disulphide bridge.{15491} The second form, SOD2, is a manganese-containing enzyme and resides in the mitochondrial matrix. It is a homotetramer of 80 kDa. The third form, SOD3 or EC-SOD, is like SOD1 in that it contains Cu and Zn ions, however it is distinct in that it is a homotetramer, with a mass of 30 kDa and it exists only in the extra-cellular space.{15494} SOD3 can also be distinguished by its heparin-binding capacity.{15489}
Brand:CaymanSKU:10011390 - 100 µlAvailable on backorder
Antigen: human Mn SOD • Host: rabbit • Cross Reactivity: (+) human, rat, mouse, bovine, canine, chicken, gerbil, guinea pig, porcine, hamster, monkey, rabbit, ovine, and Xenopus Mn SOD • Application(s): IHC, IP, and WB • SOD2 is a manganese-containing enzyme in the mitochondrial matrix that catalyzes the dismutation of the superoxide radical O2- to O2 and H2O2.
Brand:CaymanSKU:10011390- 100 µlAvailable on backorder
Antigen: human Mn SOD • Host: rabbit • Cross Reactivity: (+) human, rat, mouse, bovine, canine, chicken, gerbil, guinea pig, porcine, hamster, monkey, rabbit, ovine, and Xenopus Mn SOD • Application(s): IHC, IP, and WB • SOD2 is a manganese-containing enzyme in the mitochondrial matrix that catalyzes the dismutation of the superoxide radical O2- to O2 and H2O2.
Brand:CaymanSKU:10011390- 25 µl Superoxide dismutase (SOD) is an endogenously produced intracellular enzyme present in almost every cell in the body.{15491} It catalyzes the dismutation of the superoxide radical O2- to O2 and H2O2.{15490,15493} There are two main types of SOD in mammalian cells. One form, SOD1, contains Cu and Zn ions as a homodimer and exists in the cytoplasm. The two subunits of 16 kDa each are linked by two cystines forming an intra-subunit disulphide bridge.{15491} The second form, SOD2, is a manganese-containing enzyme and resides in the mitochondrial matrix. It is a homotetramer of 80 kDa. The third form, SOD3 or EC-SOD, is like SOD1 in that it contains Cu and Zn ions, however it is distinct in that it is a homotetramer, with a mass of 30 kDa and it exists only in the extra-cellular space.{15494} SOD3 can also be distinguished by its heparin-binding capacity.{15489}
Brand:CaymanSKU:10011390 - 25 µlAvailable on backorder
Antigen: human Mn SOD • Host: rabbit • Cross Reactivity: (+) human, rat, mouse, bovine, canine, chicken, gerbil, guinea pig, porcine, hamster, monkey, rabbit, ovine, and Xenopus Mn SOD • Application(s): IHC, IP, and WB • SOD2 is a manganese-containing enzyme in the mitochondrial matrix that catalyzes the dismutation of the superoxide radical O2- to O2 and H2O2.
Brand:CaymanSKU:10011390- 25 µlAvailable on backorder
Antigen: rat Mn SOD • Host: rabbit • Cross-reactivity: (+) human, rat, mouse, bovine, canine, chicken, Drosophila, guinea pig, porcine, hamster, monkey, rabbit, sheep, and Xenopus Mn SOD • Applications: WB, IP, IHC, and EIA • SOD2 is a manganese-containing enzyme in the mitochondrial matrix that catalyzes the dismutation of the superoxide radical O2- to O2 and H2O2.
Brand:CaymanSKU:10011389- 100 µl Superoxide dismutase (SOD) is an endogenously-produced intracellular enzyme present in almost every cell in the body.{15491} It catalyzes the dismutation of the superoxide radical O2- to O2 and H2O2.{15490,15493} There are two main types of SOD in mammalian cells. One form, SOD1, contains Cu and Zn ions as a homodimer and exists in the cytoplasm. The two subunits of 16 kDa each are linked by two cystines forming an intra-subunit disulphide bridge.{15491} The second form, SOD2, is a manganese-containing enzyme and resides in the mitochondrial matrix. It is a homotetramer of 80 kDa. The third form, SOD3 or EC-SOD, is like SOD1 in that it contains Cu and Zn ions, however it is distinct in that it is a homotetramer, with a mass of 30 kDa and it exists only in the extra-cellular space.{15494} SOD3 can also be distinguished by its heparin-binding capacity.{15489}
Brand:CaymanSKU:10011389 - 100 µlAvailable on backorder
Antigen: rat Mn SOD • Host: rabbit • Cross-reactivity: (+) human, rat, mouse, bovine, canine, chicken, Drosophila, guinea pig, porcine, hamster, monkey, rabbit, sheep, and Xenopus Mn SOD • Applications: WB, IP, IHC, and EIA • SOD2 is a manganese-containing enzyme in the mitochondrial matrix that catalyzes the dismutation of the superoxide radical O2- to O2 and H2O2.
Brand:CaymanSKU:10011389- 100 µlAvailable on backorder
Antigen: rat Mn SOD • Host: rabbit • Cross-reactivity: (+) human, rat, mouse, bovine, canine, chicken, Drosophila, guinea pig, porcine, hamster, monkey, rabbit, sheep, and Xenopus Mn SOD • Applications: WB, IP, IHC, and EIA • SOD2 is a manganese-containing enzyme in the mitochondrial matrix that catalyzes the dismutation of the superoxide radical O2- to O2 and H2O2.
Brand:CaymanSKU:10011389- 25 µl Superoxide dismutase (SOD) is an endogenously-produced intracellular enzyme present in almost every cell in the body.{15491} It catalyzes the dismutation of the superoxide radical O2- to O2 and H2O2.{15490,15493} There are two main types of SOD in mammalian cells. One form, SOD1, contains Cu and Zn ions as a homodimer and exists in the cytoplasm. The two subunits of 16 kDa each are linked by two cystines forming an intra-subunit disulphide bridge.{15491} The second form, SOD2, is a manganese-containing enzyme and resides in the mitochondrial matrix. It is a homotetramer of 80 kDa. The third form, SOD3 or EC-SOD, is like SOD1 in that it contains Cu and Zn ions, however it is distinct in that it is a homotetramer, with a mass of 30 kDa and it exists only in the extra-cellular space.{15494} SOD3 can also be distinguished by its heparin-binding capacity.{15489}
Brand:CaymanSKU:10011389 - 25 µlAvailable on backorder