Cayman
Showing 29101–29250 of 45550 results
-
Methyl 3,4-dihydroxyphenylacetate is a polyphenol that has been found in I. aquifolium seeds and has antioxidant and antiviral activities.{59010,59006} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in a cell-free assay (IC50 = 0.0025 mg/ml).{59010} Methyl 3,4-dihydroxyphenylacetate (0.01 µg/ml) inhibits enterovirus 71 replication in rhabdomyosarcoma cells.{59006}
Brand:CaymanSKU:30637 - 250 mgAvailable on backorder
Methyl 3,4-dihydroxyphenylacetate is a polyphenol that has been found in I. aquifolium seeds and has antioxidant and antiviral activities.{59010,59006} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in a cell-free assay (IC50 = 0.0025 mg/ml).{59010} Methyl 3,4-dihydroxyphenylacetate (0.01 µg/ml) inhibits enterovirus 71 replication in rhabdomyosarcoma cells.{59006}
Brand:CaymanSKU:30637 - 500 mgAvailable on backorder
Brand:CaymanSKU:10007114 - 1 gAvailable on backorder
Brand:CaymanSKU:10007114 - 100 mgAvailable on backorder
Brand:CaymanSKU:10007114 - 500 mgAvailable on backorder
Risperidone (Item No. 13629) is a benzisoxazole derivative used for treating schizophrenia, and also the psychotic, affective, or behavioral symptoms associated with other disorders.{17629,17608} Methyl 5,6,7,8-tetradehydro risperidone is used as an internal standard used in the quantitative analysis of risperidone.{28961,28960}
Brand:CaymanSKU:-Available on backorder
Risperidone (Item No. 13629) is a benzisoxazole derivative used for treating schizophrenia, and also the psychotic, affective, or behavioral symptoms associated with other disorders.{17629,17608} Methyl 5,6,7,8-tetradehydro risperidone is used as an internal standard used in the quantitative analysis of risperidone.{28961,28960}
Brand:CaymanSKU:-Available on backorder
Risperidone (Item No. 13629) is a benzisoxazole derivative used for treating schizophrenia, and also the psychotic, affective, or behavioral symptoms associated with other disorders.{17629,17608} Methyl 5,6,7,8-tetradehydro risperidone is used as an internal standard used in the quantitative analysis of risperidone.{28961,28960}
Brand:CaymanSKU:-Available on backorder
Methyl arachidonyl fluorophosphonate (MAFP) is an inhibitor of monoacylglycerol lipase (MAGL) and fatty acid amide hydrolase (FAAH; IC50s = 26 and 0.33 nM, respectively).{53947} It is also an irreversible inhibitor of cytosolic phospholipase A2 (cPLA2), as well as calcium-independent PLA2 (iPLA2; IC50 = 500 nM).{2494,2989,2302} MAFP inhibits A23187-induced arachidonic acid release from human platelets with an IC50 value of 600 nM.{2494}
Brand:CaymanSKU:70660 - 1 mgAvailable on backorder
Methyl arachidonyl fluorophosphonate (MAFP) is an inhibitor of monoacylglycerol lipase (MAGL) and fatty acid amide hydrolase (FAAH; IC50s = 26 and 0.33 nM, respectively).{53947} It is also an irreversible inhibitor of cytosolic phospholipase A2 (cPLA2), as well as calcium-independent PLA2 (iPLA2; IC50 = 500 nM).{2494,2989,2302} MAFP inhibits A23187-induced arachidonic acid release from human platelets with an IC50 value of 600 nM.{2494}
Brand:CaymanSKU:70660 - 10 mgAvailable on backorder
Methyl arachidonyl fluorophosphonate (MAFP) is an inhibitor of monoacylglycerol lipase (MAGL) and fatty acid amide hydrolase (FAAH; IC50s = 26 and 0.33 nM, respectively).{53947} It is also an irreversible inhibitor of cytosolic phospholipase A2 (cPLA2), as well as calcium-independent PLA2 (iPLA2; IC50 = 500 nM).{2494,2989,2302} MAFP inhibits A23187-induced arachidonic acid release from human platelets with an IC50 value of 600 nM.{2494}
Brand:CaymanSKU:70660 - 25 mgAvailable on backorder
Methyl arachidonyl fluorophosphonate (MAFP) is an inhibitor of monoacylglycerol lipase (MAGL) and fatty acid amide hydrolase (FAAH; IC50s = 26 and 0.33 nM, respectively).{53947} It is also an irreversible inhibitor of cytosolic phospholipase A2 (cPLA2), as well as calcium-independent PLA2 (iPLA2; IC50 = 500 nM).{2494,2989,2302} MAFP inhibits A23187-induced arachidonic acid release from human platelets with an IC50 value of 600 nM.{2494}
Brand:CaymanSKU:70660 - 5 mgAvailable on backorder
Methyl cyclohexanecarboxylate is an aliphatic ester that has been used in a variety of chemical synthesis studies, including the preparation of primary amides and reduction of esters to alcohols.{55103,55104}
Brand:CaymanSKU:30403 - 10 gAvailable on backorder
Methyl cyclohexanecarboxylate is an aliphatic ester that has been used in a variety of chemical synthesis studies, including the preparation of primary amides and reduction of esters to alcohols.{55103,55104}
Brand:CaymanSKU:30403 - 50 gAvailable on backorder
Methyl gallate is a phenol that has been found in Meliaceae and has diverse biological activities.{61066,61081,32922,31596} It reduces adipogenic hormonal stimulation-induced lipid accumulation in 3T3-L1 cells when used at a concentration of 50 µM.{61066} Methyl gallate is active against V. cholerae in vitro (MIC = 32 µg/ml) and reduces V. cholerae-induced intestinal fluid accumulation in suckling mice when administered at doses of 50, 100, and 200 mg/kg.{61081} It reduces tumor growth and decreases the number of intratumor CD25+Foxp3high regulatory T cells (Tregs) in an EL-4 model of murine lymphoma.{32922} Methyl gallate (0.7, 7, and 70 mg/kg) reduces knee joint edema and leukocyte, neutrophil, and mononuclear cell infiltration in a mouse model of zymosan-induced arthritis.{31596}
Brand:CaymanSKU:19951 -Available on backorder
Methyl gallate is a phenol that has been found in Meliaceae and has diverse biological activities.{61066,61081,32922,31596} It reduces adipogenic hormonal stimulation-induced lipid accumulation in 3T3-L1 cells when used at a concentration of 50 µM.{61066} Methyl gallate is active against V. cholerae in vitro (MIC = 32 µg/ml) and reduces V. cholerae-induced intestinal fluid accumulation in suckling mice when administered at doses of 50, 100, and 200 mg/kg.{61081} It reduces tumor growth and decreases the number of intratumor CD25+Foxp3high regulatory T cells (Tregs) in an EL-4 model of murine lymphoma.{32922} Methyl gallate (0.7, 7, and 70 mg/kg) reduces knee joint edema and leukocyte, neutrophil, and mononuclear cell infiltration in a mouse model of zymosan-induced arthritis.{31596}
Brand:CaymanSKU:19951 -Available on backorder
Methyl gallate is a phenol that has been found in Meliaceae and has diverse biological activities.{61066,61081,32922,31596} It reduces adipogenic hormonal stimulation-induced lipid accumulation in 3T3-L1 cells when used at a concentration of 50 µM.{61066} Methyl gallate is active against V. cholerae in vitro (MIC = 32 µg/ml) and reduces V. cholerae-induced intestinal fluid accumulation in suckling mice when administered at doses of 50, 100, and 200 mg/kg.{61081} It reduces tumor growth and decreases the number of intratumor CD25+Foxp3high regulatory T cells (Tregs) in an EL-4 model of murine lymphoma.{32922} Methyl gallate (0.7, 7, and 70 mg/kg) reduces knee joint edema and leukocyte, neutrophil, and mononuclear cell infiltration in a mouse model of zymosan-induced arthritis.{31596}
Brand:CaymanSKU:19951 -Available on backorder
Methyl gallate is a phenol that has been found in Meliaceae and has diverse biological activities.{61066,61081,32922,31596} It reduces adipogenic hormonal stimulation-induced lipid accumulation in 3T3-L1 cells when used at a concentration of 50 µM.{61066} Methyl gallate is active against V. cholerae in vitro (MIC = 32 µg/ml) and reduces V. cholerae-induced intestinal fluid accumulation in suckling mice when administered at doses of 50, 100, and 200 mg/kg.{61081} It reduces tumor growth and decreases the number of intratumor CD25+Foxp3high regulatory T cells (Tregs) in an EL-4 model of murine lymphoma.{32922} Methyl gallate (0.7, 7, and 70 mg/kg) reduces knee joint edema and leukocyte, neutrophil, and mononuclear cell infiltration in a mouse model of zymosan-induced arthritis.{31596}
Brand:CaymanSKU:19951 -Available on backorder
Methyl parathion is an organophosphate insecticide.{41949} It is converted into an oxon-containing metabolite in vivo, similar to other organophosphate pesticides, that inhibits acetylcholinesterase. Methyl parathion is lethal to lab strains and field isolates of tobacco budworm larvae (LD50s = 7 and 81.8-128.3 μg/g, respectively).{45030} It reduces the number of stink bugs (C. sayi) caught per 100 net sweeps when applied to alfalfa fields at a concentration of 0.4 pounds per acre.{45031} Methyl parathion increases sister chromatid exchange (SCE) in a concentration-dependent manner and induces cell cycle arrest at the M1 phase in V79 cells at a concentration of 40 μg/ml.{42227} It is toxic to rats (LD50 = 14 mg/kg).{41949}
Brand:CaymanSKU:25786 - 100 mgAvailable on backorder
Methyl parathion is an organophosphate insecticide.{41949} It is converted into an oxon-containing metabolite in vivo, similar to other organophosphate pesticides, that inhibits acetylcholinesterase. Methyl parathion is lethal to lab strains and field isolates of tobacco budworm larvae (LD50s = 7 and 81.8-128.3 μg/g, respectively).{45030} It reduces the number of stink bugs (C. sayi) caught per 100 net sweeps when applied to alfalfa fields at a concentration of 0.4 pounds per acre.{45031} Methyl parathion increases sister chromatid exchange (SCE) in a concentration-dependent manner and induces cell cycle arrest at the M1 phase in V79 cells at a concentration of 40 μg/ml.{42227} It is toxic to rats (LD50 = 14 mg/kg).{41949}
Brand:CaymanSKU:25786 - 50 mgAvailable on backorder
MγLnFP is an analog of methyl arachidonyl fluozophosphonate (MAFP; Item No. 70660), which has been widely studied as an inhibitor of phospholipases, FAAH, and as a CB receptor ligand.{2494,4314,2989} The pharmacology of the γ-linolenyl analog of MAFP has not been completely investigated.
Brand:CaymanSKU:70664 - 1 mgAvailable on backorder
MγLnFP is an analog of methyl arachidonyl fluozophosphonate (MAFP; Item No. 70660), which has been widely studied as an inhibitor of phospholipases, FAAH, and as a CB receptor ligand.{2494,4314,2989} The pharmacology of the γ-linolenyl analog of MAFP has not been completely investigated.
Brand:CaymanSKU:70664 - 10 mgAvailable on backorder
MγLnFP is an analog of methyl arachidonyl fluozophosphonate (MAFP; Item No. 70660), which has been widely studied as an inhibitor of phospholipases, FAAH, and as a CB receptor ligand.{2494,4314,2989} The pharmacology of the γ-linolenyl analog of MAFP has not been completely investigated.
Brand:CaymanSKU:70664 - 5 mgAvailable on backorder
BB-22 (Item No. 14099) is synthetic cannabinoid which has been identified in herbal mixtures.{23290} It is a quinolinyl cyclohexyl indole with a carboxylate group, abbreviated as QUCHIC.{23290} methyl-1-(cyclohexylmethyl)-1H-indole-3-Carboxylate is an analog of BB-22 that lacks the quinoline group. The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research applications.
Brand:CaymanSKU:- BB-22 (Item No. 14099) is synthetic cannabinoid which has been identified in herbal mixtures.{23290} It is a quinolinyl cyclohexyl indole with a carboxylate group, abbreviated as QUCHIC.{23290} methyl-1-(cyclohexylmethyl)-1H-indole-3-Carboxylate is an analog of BB-22 that lacks the quinoline group. The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research applications.
Brand:CaymanSKU:- BB-22 (Item No. 14099) is synthetic cannabinoid which has been identified in herbal mixtures.{23290} It is a quinolinyl cyclohexyl indole with a carboxylate group, abbreviated as QUCHIC.{23290} methyl-1-(cyclohexylmethyl)-1H-indole-3-Carboxylate is an analog of BB-22 that lacks the quinoline group. The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research applications.
Brand:CaymanSKU:-
PB-22 (Item No. 14096) is synthetic cannabinoid that has been identified in herbal mixtures.{23290} It is a quinolinyl pentyl indole with a carboxylate group, abbreviated as QUPIC.{23290} methy-1-pentyl-1H-indole-3-Carboxylate is an analog of PB-22 that lacks the quinoline group. The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research applications.
Brand:CaymanSKU:- PB-22 (Item No. 14096) is synthetic cannabinoid that has been identified in herbal mixtures.{23290} It is a quinolinyl pentyl indole with a carboxylate group, abbreviated as QUPIC.{23290} methy-1-pentyl-1H-indole-3-Carboxylate is an analog of PB-22 that lacks the quinoline group. The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research applications.
Brand:CaymanSKU:- PB-22 (Item No. 14096) is synthetic cannabinoid that has been identified in herbal mixtures.{23290} It is a quinolinyl pentyl indole with a carboxylate group, abbreviated as QUPIC.{23290} methy-1-pentyl-1H-indole-3-Carboxylate is an analog of PB-22 that lacks the quinoline group. The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research applications.
Brand:CaymanSKU:-
Nitric oxide synthase (NOS) catalyzes the conversion of L-arginine to nitric oxide (NO) and citrulline. Methyl-L-NIO (hydrochloride) is a competitive nitric oxide synthase (NOS) inhibitor that competes with L-arginine for the amino acid binding site. It is a more potent inhibitor of nNOS (Ki = 3.0 µM) than eNOS (Ki = 10.0 µM) or iNOS (Ki = 9.5 µM).{6358}
Brand:CaymanSKU:10010252 - 10 mgAvailable on backorder
Nitric oxide synthase (NOS) catalyzes the conversion of L-arginine to nitric oxide (NO) and citrulline. Methyl-L-NIO (hydrochloride) is a competitive nitric oxide synthase (NOS) inhibitor that competes with L-arginine for the amino acid binding site. It is a more potent inhibitor of nNOS (Ki = 3.0 µM) than eNOS (Ki = 10.0 µM) or iNOS (Ki = 9.5 µM).{6358}
Brand:CaymanSKU:10010252 - 25 mgAvailable on backorder
Nitric oxide synthase (NOS) catalyzes the conversion of L-arginine to nitric oxide (NO) and citrulline. Methyl-L-NIO (hydrochloride) is a competitive nitric oxide synthase (NOS) inhibitor that competes with L-arginine for the amino acid binding site. It is a more potent inhibitor of nNOS (Ki = 3.0 µM) than eNOS (Ki = 10.0 µM) or iNOS (Ki = 9.5 µM).{6358}
Brand:CaymanSKU:10010252 - 5 mgAvailable on backorder
Nitric oxide synthase (NOS) catalyzes the conversion of L-arginine to nitric oxide (NO) and citrulline. Methyl-L-NIO (hydrochloride) is a competitive nitric oxide synthase (NOS) inhibitor that competes with L-arginine for the amino acid binding site. It is a more potent inhibitor of nNOS (Ki = 3.0 µM) than eNOS (Ki = 10.0 µM) or iNOS (Ki = 9.5 µM).{6358}
Brand:CaymanSKU:10010252 - 50 mgAvailable on backorder
Methyl-β-cyclodextrin is a randomly methylated form of the cyclic oligosaccharide β-cyclodextrin (Item No. 23387).{26620} Methyl-β-cyclodextrin contains seven D-(+)-glucopyranose units that contain randomized hydrogen or methyl groups. Methyl-β-cyclodextrin has been used to improve the aqueous solubility of various compounds and to extract cholesterol from lipid membranes.{26620,46005} Methyl-β-cyclodextrin (5 mM) reduces α-synuclein levels in the membrane and detergent-insoluble fractions from B103 neuroblastoma cells transfected with human α-synuclein.{46006} It also reduces α-synuclein levels in mouse brain in a transgenic model of α-synucleinopathy.
Brand:CaymanSKU:21633 -Out of stock
Methyl-β-cyclodextrin is a randomly methylated form of the cyclic oligosaccharide β-cyclodextrin (Item No. 23387).{26620} Methyl-β-cyclodextrin contains seven D-(+)-glucopyranose units that contain randomized hydrogen or methyl groups. Methyl-β-cyclodextrin has been used to improve the aqueous solubility of various compounds and to extract cholesterol from lipid membranes.{26620,46005} Methyl-β-cyclodextrin (5 mM) reduces α-synuclein levels in the membrane and detergent-insoluble fractions from B103 neuroblastoma cells transfected with human α-synuclein.{46006} It also reduces α-synuclein levels in mouse brain in a transgenic model of α-synucleinopathy.
Brand:CaymanSKU:21633 -Out of stock
Methyl-β-cyclodextrin is a randomly methylated form of the cyclic oligosaccharide β-cyclodextrin (Item No. 23387).{26620} Methyl-β-cyclodextrin contains seven D-(+)-glucopyranose units that contain randomized hydrogen or methyl groups. Methyl-β-cyclodextrin has been used to improve the aqueous solubility of various compounds and to extract cholesterol from lipid membranes.{26620,46005} Methyl-β-cyclodextrin (5 mM) reduces α-synuclein levels in the membrane and detergent-insoluble fractions from B103 neuroblastoma cells transfected with human α-synuclein.{46006} It also reduces α-synuclein levels in mouse brain in a transgenic model of α-synucleinopathy.
Brand:CaymanSKU:21633 -Out of stock
Methyl-β-cyclodextrin is a randomly methylated form of the cyclic oligosaccharide β-cyclodextrin (Item No. 23387).{26620} Methyl-β-cyclodextrin contains seven D-(+)-glucopyranose units that contain randomized hydrogen or methyl groups. Methyl-β-cyclodextrin has been used to improve the aqueous solubility of various compounds and to extract cholesterol from lipid membranes.{26620,46005} Methyl-β-cyclodextrin (5 mM) reduces α-synuclein levels in the membrane and detergent-insoluble fractions from B103 neuroblastoma cells transfected with human α-synuclein.{46006} It also reduces α-synuclein levels in mouse brain in a transgenic model of α-synucleinopathy.
Brand:CaymanSKU:21633 -Out of stock
Immunogen: Methylated KLH conjugated • Host: Rabbit • Cross Reactivity: (+) Mono- and di-methylated lysine residues in multiple species (cross-reactivity with tri-methyl lysine has not been tested); (−) Acetylated lysine • Application: ELISA, IHC, IP, and WB • Lysine can be methylated once, twice, or three times by lysine methyltransferases. The transfer of methyl groups from SAM to histones is catalyzed by histone methyltransferases.
Brand:CaymanSKU:31686- 100 µg Post-translational modifications of proteins play critical roles in the regulation and function of many known biological processes. Proteins can be post-translationally modified in many different ways, and a common post-transcriptional modification of lysine involves methylation.{17715} Lysine can be methylated once, twice, or three times by lysine methyltransferases. The transfer of methyl groups from S-adenosyl methionine to histones is catalyzed by enzymes known as histone methyltransferases. Histones which are methylated on certain residues can act epigenetically to repress or activate gene expression.{17715,17725}
Brand:CaymanSKU:31686 - 100 µgAvailable on backorder
Immunogen: Methylated KLH conjugated • Host: Rabbit • Cross Reactivity: (+) Mono- and di-methylated lysine residues in multiple species (cross-reactivity with tri-methyl lysine has not been tested); (−) Acetylated lysine • Application: ELISA, IHC, IP, and WB • Lysine can be methylated once, twice, or three times by lysine methyltransferases. The transfer of methyl groups from SAM to histones is catalyzed by histone methyltransferases.
Brand:CaymanSKU:31686- 100 µgAvailable on backorder
Post-translational modifications of proteins play critical roles in the regulation and function of many known biological processes. Proteins can be post-translationally modified in many different ways, and a common post-transcriptional modification of lysine involves methylation.{17715} Lysine can be methylated once, twice, or three times by lysine methyltransferases. The transfer of methyl groups from S-adenosyl methionine to histones is catalyzed by enzymes known as histone methyltransferases. Histones which are methylated on certain residues can act epigenetically to repress or activate gene expression.{17715,17725}
Brand:CaymanSKU:13728 - 100 µgAvailable on backorder
Immunogen: Methylated KLH Conjugated • Host: Rabbit • Species Reactivity: Species Independent • Application(s): ELISA, ICC/IF, IP, and WB • Lysine can be methylated once, twice, or three times by lysine methyltransferases. The transfer of methyl groups from SAM to histones is catalyzed by histone methyltransferases.
Brand:CaymanSKU:13728- 100 µgAvailable on backorder
Immunogen: Methylated KLH Conjugated • Host: Rabbit • Species Reactivity: Species Independent • Application(s): ELISA, ICC/IF, IP, and WB • Lysine can be methylated once, twice, or three times by lysine methyltransferases. The transfer of methyl groups from SAM to histones is catalyzed by histone methyltransferases.
Brand:CaymanSKU:13728- 100 µg
Methylcarbamyl PAF C-16 is a stable analog of PAF C-16 with a half-life greater than 100 minutes in platelet poor plasma due to its resistance to degradation by PAF-AH.{613,4944} It is nearly equipotent with PAF C-16 in its ability to induce platelet aggregation both in isolated platelets and in platelet-rich plasma.{613} In NRK-49 cells overexpressing the PAF receptor, both PAF C-16 and methylcarbamyl PAF C-16 cause the induction of c-myc and c-fos and the activation of mitogen-activated protein kinase.{4944} Methylcarbamyl PAF C-16 induces G1 phase cell cycle arrest, suggesting a potential role for PAF in the inhibition of oncogenic transformation.{4944}
Brand:CaymanSKU:60908 - 1 mgAvailable on backorder
Methylcarbamyl PAF C-16 is a stable analog of PAF C-16 with a half-life greater than 100 minutes in platelet poor plasma due to its resistance to degradation by PAF-AH.{613,4944} It is nearly equipotent with PAF C-16 in its ability to induce platelet aggregation both in isolated platelets and in platelet-rich plasma.{613} In NRK-49 cells overexpressing the PAF receptor, both PAF C-16 and methylcarbamyl PAF C-16 cause the induction of c-myc and c-fos and the activation of mitogen-activated protein kinase.{4944} Methylcarbamyl PAF C-16 induces G1 phase cell cycle arrest, suggesting a potential role for PAF in the inhibition of oncogenic transformation.{4944}
Brand:CaymanSKU:60908 - 10 mgAvailable on backorder
Methylcarbamyl PAF C-16 is a stable analog of PAF C-16 with a half-life greater than 100 minutes in platelet poor plasma due to its resistance to degradation by PAF-AH.{613,4944} It is nearly equipotent with PAF C-16 in its ability to induce platelet aggregation both in isolated platelets and in platelet-rich plasma.{613} In NRK-49 cells overexpressing the PAF receptor, both PAF C-16 and methylcarbamyl PAF C-16 cause the induction of c-myc and c-fos and the activation of mitogen-activated protein kinase.{4944} Methylcarbamyl PAF C-16 induces G1 phase cell cycle arrest, suggesting a potential role for PAF in the inhibition of oncogenic transformation.{4944}
Brand:CaymanSKU:60908 - 25 mgAvailable on backorder
Methylcarbamyl PAF C-16 is a stable analog of PAF C-16 with a half-life greater than 100 minutes in platelet poor plasma due to its resistance to degradation by PAF-AH.{613,4944} It is nearly equipotent with PAF C-16 in its ability to induce platelet aggregation both in isolated platelets and in platelet-rich plasma.{613} In NRK-49 cells overexpressing the PAF receptor, both PAF C-16 and methylcarbamyl PAF C-16 cause the induction of c-myc and c-fos and the activation of mitogen-activated protein kinase.{4944} Methylcarbamyl PAF C-16 induces G1 phase cell cycle arrest, suggesting a potential role for PAF in the inhibition of oncogenic transformation.{4944}
Brand:CaymanSKU:60908 - 5 mgAvailable on backorder
Methylcardol triene is a phenol found in cashew nut shell liquid that inhibits α-glucosidase (IC50 = 39.6 µM).{36153} It is schistosomicidal, killing 100% of adult S. mansoni worms after 24 hours when used at concentrations of 100 and 200 µM.{361514} It has been used as a starting material for the synthesis of mono- and bis-benzoxazines.{36152}
Brand:CaymanSKU:23404 - 1 mgAvailable on backorder
Methylcardol triene is a phenol found in cashew nut shell liquid that inhibits α-glucosidase (IC50 = 39.6 µM).{36153} It is schistosomicidal, killing 100% of adult S. mansoni worms after 24 hours when used at concentrations of 100 and 200 µM.{361514} It has been used as a starting material for the synthesis of mono- and bis-benzoxazines.{36152}
Brand:CaymanSKU:23404 - 10 mgAvailable on backorder
Methylcardol triene is a phenol found in cashew nut shell liquid that inhibits α-glucosidase (IC50 = 39.6 µM).{36153} It is schistosomicidal, killing 100% of adult S. mansoni worms after 24 hours when used at concentrations of 100 and 200 µM.{361514} It has been used as a starting material for the synthesis of mono- and bis-benzoxazines.{36152}
Brand:CaymanSKU:23404 - 5 mgAvailable on backorder
Methylcardol triene is a phenol found in cashew nut shell liquid that inhibits α-glucosidase (IC50 = 39.6 µM).{36153} It is schistosomicidal, killing 100% of adult S. mansoni worms after 24 hours when used at concentrations of 100 and 200 µM.{361514} It has been used as a starting material for the synthesis of mono- and bis-benzoxazines.{36152}
Brand:CaymanSKU:23404 - 500 µgAvailable on backorder
Methylclonazepam (Item No. 22747) is an analytical reference standard categorized as a benzodiazepine.{46026} This product is intended for research and forensic applications.
Brand:CaymanSKU:22747 -Out of stock
Methylclonazepam (Item No. 22747) is an analytical reference standard categorized as a benzodiazepine.{46026} This product is intended for research and forensic applications.
Brand:CaymanSKU:22747 -Out of stock
Methylcobalamin is an analog of vitamin B12 (Item No. 18425) with diverse neurological activities.{52229,52230,52231,52232} It promotes neurite outgrowth and survival in primary cerebellar granule (CGN) and dorsal root ganglion (DRG) cells and activation of ERK1/2 and Akt when used at concentrations ranging from 0.1 to 100 µM.{52229} Methylcobalamin (1 mg/kg per day) improves sensory function in a pinch test and increases toe spreading in a rat model of sciatic nerve injury. It decreases the number of atypical mitochondria in the sciatic nerve and reduces mechanical allodynia and thermal hyperalgesia induced by vincristine (Item No. 11764) in a rat model of neuropathic pain.{52230} Methylcobalamin (30 mg/kg) reduces muscle weakness and forelimb contracture and increases bicep muscle weight and the number of musculocutaneous nerves in the wobbler mouse model of amyotrophic lateral sclerosis (ALS).{52231} It also enhances the recovery of compound muscle action potentials and motor end plate innervation and decreases the time to sticker removal in the sticker removal grooming test in a rat model of bicep ulnar to musculocutaneous nerve transfer.{52232}
Brand:CaymanSKU:29113 - 1 gAvailable on backorder
Methylcobalamin is an analog of vitamin B12 (Item No. 18425) with diverse neurological activities.{52229,52230,52231,52232} It promotes neurite outgrowth and survival in primary cerebellar granule (CGN) and dorsal root ganglion (DRG) cells and activation of ERK1/2 and Akt when used at concentrations ranging from 0.1 to 100 µM.{52229} Methylcobalamin (1 mg/kg per day) improves sensory function in a pinch test and increases toe spreading in a rat model of sciatic nerve injury. It decreases the number of atypical mitochondria in the sciatic nerve and reduces mechanical allodynia and thermal hyperalgesia induced by vincristine (Item No. 11764) in a rat model of neuropathic pain.{52230} Methylcobalamin (30 mg/kg) reduces muscle weakness and forelimb contracture and increases bicep muscle weight and the number of musculocutaneous nerves in the wobbler mouse model of amyotrophic lateral sclerosis (ALS).{52231} It also enhances the recovery of compound muscle action potentials and motor end plate innervation and decreases the time to sticker removal in the sticker removal grooming test in a rat model of bicep ulnar to musculocutaneous nerve transfer.{52232}
Brand:CaymanSKU:29113 - 100 mgAvailable on backorder
Methylcobalamin is an analog of vitamin B12 (Item No. 18425) with diverse neurological activities.{52229,52230,52231,52232} It promotes neurite outgrowth and survival in primary cerebellar granule (CGN) and dorsal root ganglion (DRG) cells and activation of ERK1/2 and Akt when used at concentrations ranging from 0.1 to 100 µM.{52229} Methylcobalamin (1 mg/kg per day) improves sensory function in a pinch test and increases toe spreading in a rat model of sciatic nerve injury. It decreases the number of atypical mitochondria in the sciatic nerve and reduces mechanical allodynia and thermal hyperalgesia induced by vincristine (Item No. 11764) in a rat model of neuropathic pain.{52230} Methylcobalamin (30 mg/kg) reduces muscle weakness and forelimb contracture and increases bicep muscle weight and the number of musculocutaneous nerves in the wobbler mouse model of amyotrophic lateral sclerosis (ALS).{52231} It also enhances the recovery of compound muscle action potentials and motor end plate innervation and decreases the time to sticker removal in the sticker removal grooming test in a rat model of bicep ulnar to musculocutaneous nerve transfer.{52232}
Brand:CaymanSKU:29113 - 250 mgAvailable on backorder
Methylcobalamin is an analog of vitamin B12 (Item No. 18425) with diverse neurological activities.{52229,52230,52231,52232} It promotes neurite outgrowth and survival in primary cerebellar granule (CGN) and dorsal root ganglion (DRG) cells and activation of ERK1/2 and Akt when used at concentrations ranging from 0.1 to 100 µM.{52229} Methylcobalamin (1 mg/kg per day) improves sensory function in a pinch test and increases toe spreading in a rat model of sciatic nerve injury. It decreases the number of atypical mitochondria in the sciatic nerve and reduces mechanical allodynia and thermal hyperalgesia induced by vincristine (Item No. 11764) in a rat model of neuropathic pain.{52230} Methylcobalamin (30 mg/kg) reduces muscle weakness and forelimb contracture and increases bicep muscle weight and the number of musculocutaneous nerves in the wobbler mouse model of amyotrophic lateral sclerosis (ALS).{52231} It also enhances the recovery of compound muscle action potentials and motor end plate innervation and decreases the time to sticker removal in the sticker removal grooming test in a rat model of bicep ulnar to musculocutaneous nerve transfer.{52232}
Brand:CaymanSKU:29113 - 500 mgAvailable on backorder
Methyldopate is an ethyl ester prodrug form of methyldopa (Item No. 21814), a dopamine decarboxylase inhibitor that has antihypertensive activity in vitro and in vivo.{36001,36002,36000},{37260} Formulations containing methyldopate have been used in the treatment of hypertension.
Brand:CaymanSKU:24002 - 1 mgAvailable on backorder
Methyldopate is an ethyl ester prodrug form of methyldopa (Item No. 21814), a dopamine decarboxylase inhibitor that has antihypertensive activity in vitro and in vivo.{36001,36002,36000},{37260} Formulations containing methyldopate have been used in the treatment of hypertension.
Brand:CaymanSKU:24002 - 10 mgAvailable on backorder
Methyldopate is an ethyl ester prodrug form of methyldopa (Item No. 21814), a dopamine decarboxylase inhibitor that has antihypertensive activity in vitro and in vivo.{36001,36002,36000},{37260} Formulations containing methyldopate have been used in the treatment of hypertension.
Brand:CaymanSKU:24002 - 5 mgAvailable on backorder
Methylene blue is a cationic thiazine dye that has diverse biological activities.{47160,47163,47161} It inhibits the catalytic function of inducible and constitutive nitric oxide synthases via oxidation of enzyme-bound ferrous iron.{47160} Methylene blue also inhibits monoamine oxidase (MAO) and increases the activity of mitochondrial cytochrome C oxidase (complex IV).{47163,47161} In vivo, methylene blue stabilizes systemic circulation without increasing peripheral resistance, decreases lipid peroxidation, and reduces anoxic tissue injury in brain and heart in a porcine model of global ischemia and reperfusion injury.{47160} It inhibits MAO activity in brain and reduces the age-related decline in grip strength and spatial memory in old mice when administered in drinking water at a concentration of 250 μM.{47163} Methylene blue (15, 30, and 60 mg/kg) also reduces immobility time in the forced swim test in mice, indicating antidepressant-like activity.{47161} Methylene blue is commonly used to stain cells and tissues in research.{47162}
Brand:CaymanSKU:26095 - 100 gAvailable on backorder
Methylene blue is a cationic thiazine dye that has diverse biological activities.{47160,47163,47161} It inhibits the catalytic function of inducible and constitutive nitric oxide synthases via oxidation of enzyme-bound ferrous iron.{47160} Methylene blue also inhibits monoamine oxidase (MAO) and increases the activity of mitochondrial cytochrome C oxidase (complex IV).{47163,47161} In vivo, methylene blue stabilizes systemic circulation without increasing peripheral resistance, decreases lipid peroxidation, and reduces anoxic tissue injury in brain and heart in a porcine model of global ischemia and reperfusion injury.{47160} It inhibits MAO activity in brain and reduces the age-related decline in grip strength and spatial memory in old mice when administered in drinking water at a concentration of 250 μM.{47163} Methylene blue (15, 30, and 60 mg/kg) also reduces immobility time in the forced swim test in mice, indicating antidepressant-like activity.{47161} Methylene blue is commonly used to stain cells and tissues in research.{47162}
Brand:CaymanSKU:26095 - 25 gAvailable on backorder
Methylene blue is a cationic thiazine dye that has diverse biological activities.{47160,47163,47161} It inhibits the catalytic function of inducible and constitutive nitric oxide synthases via oxidation of enzyme-bound ferrous iron.{47160} Methylene blue also inhibits monoamine oxidase (MAO) and increases the activity of mitochondrial cytochrome C oxidase (complex IV).{47163,47161} In vivo, methylene blue stabilizes systemic circulation without increasing peripheral resistance, decreases lipid peroxidation, and reduces anoxic tissue injury in brain and heart in a porcine model of global ischemia and reperfusion injury.{47160} It inhibits MAO activity in brain and reduces the age-related decline in grip strength and spatial memory in old mice when administered in drinking water at a concentration of 250 μM.{47163} Methylene blue (15, 30, and 60 mg/kg) also reduces immobility time in the forced swim test in mice, indicating antidepressant-like activity.{47161} Methylene blue is commonly used to stain cells and tissues in research.{47162}
Brand:CaymanSKU:26095 - 250 gAvailable on backorder
Methylene blue is a cationic thiazine dye that has diverse biological activities.{47160,47163,47161} It inhibits the catalytic function of inducible and constitutive nitric oxide synthases via oxidation of enzyme-bound ferrous iron.{47160} Methylene blue also inhibits monoamine oxidase (MAO) and increases the activity of mitochondrial cytochrome C oxidase (complex IV).{47163,47161} In vivo, methylene blue stabilizes systemic circulation without increasing peripheral resistance, decreases lipid peroxidation, and reduces anoxic tissue injury in brain and heart in a porcine model of global ischemia and reperfusion injury.{47160} It inhibits MAO activity in brain and reduces the age-related decline in grip strength and spatial memory in old mice when administered in drinking water at a concentration of 250 μM.{47163} Methylene blue (15, 30, and 60 mg/kg) also reduces immobility time in the forced swim test in mice, indicating antidepressant-like activity.{47161} Methylene blue is commonly used to stain cells and tissues in research.{47162}
Brand:CaymanSKU:26095 - 50 gAvailable on backorder
Methylhexanamine (hydrochloride) is a simple aliphatic amine that was once marketed as a nasal decongestant (Forthane) but is now sold as a bodybuilding supplement (Floradrene, Geranamine). It is also sold as a mild stimulant in the form of party pills and has been reported to cause cerebral hemorrhage in a case report.{19973} While little is known about its mode of action, methylhexanamine interferes in immunoassays for amphetamines, presumably because of the common ethylamine structure.{19974} This compound is intended for forensic or research purposes.
Brand:CaymanSKU:10749 - 10 mgAvailable on backorder
Methylhexanamine (hydrochloride) is a simple aliphatic amine that was once marketed as a nasal decongestant (Forthane) but is now sold as a bodybuilding supplement (Floradrene, Geranamine). It is also sold as a mild stimulant in the form of party pills and has been reported to cause cerebral hemorrhage in a case report.{19973} While little is known about its mode of action, methylhexanamine interferes in immunoassays for amphetamines, presumably because of the common ethylamine structure.{19974} This compound is intended for forensic or research purposes.
Brand:CaymanSKU:10749 - 5 mgAvailable on backorder
Methylhexanamine (hydrochloride) is a simple aliphatic amine that was once marketed as a nasal decongestant (Forthane) but is now sold as a bodybuilding supplement (Floradrene, Geranamine). It is also sold as a mild stimulant in the form of party pills and has been reported to cause cerebral hemorrhage in a case report.{19973} While little is known about its mode of action, methylhexanamine interferes in immunoassays for amphetamines, presumably because of the common ethylamine structure.{19974} This compound is intended for forensic or research purposes.
Brand:CaymanSKU:10749 - 50 mgAvailable on backorder
Methylhomatropine is an anticholinergic agent.{36327} It blocks spasm of rat and rabbit intestines induced by acetylcholine (Item No. 23829) ex vivo (ED50s = 0.052 and 0.011 mg/kg, respectively). Methylhomatropine slows intestinal transit of a charcoal meal in rats (ED50 = 27 mg/kg) and blocks salivary gland secretion in rabbits (ED50 = 0.16 mg/kg). It also induces mydriasis in mice when administered subcutaneously or orally (ED50s = 0.13 and 12 mg/kg, respectively). Formulations containing methylhomatropine have been used in the treatment of nausea, vomiting, and motion sickness.
Brand:CaymanSKU:23832 - 1 gAvailable on backorder
Methylhomatropine is an anticholinergic agent.{36327} It blocks spasm of rat and rabbit intestines induced by acetylcholine (Item No. 23829) ex vivo (ED50s = 0.052 and 0.011 mg/kg, respectively). Methylhomatropine slows intestinal transit of a charcoal meal in rats (ED50 = 27 mg/kg) and blocks salivary gland secretion in rabbits (ED50 = 0.16 mg/kg). It also induces mydriasis in mice when administered subcutaneously or orally (ED50s = 0.13 and 12 mg/kg, respectively). Formulations containing methylhomatropine have been used in the treatment of nausea, vomiting, and motion sickness.
Brand:CaymanSKU:23832 - 5 gAvailable on backorder
Methylisothiazolinone (MI) is an isothiazolinone-derived biocide used for controlling microbial growth in industrial and household products, often in a mixture with 5-chloro-2-methyl-3-isothiazolone (MCI).{37117,30031} MI is active against Gram-positive and Gram-negative bacteria, fungi, and yeast with MIC values of 0.0045, 0.0015, >0.01, and 0.0065% (w/w) for S. aureus, P. aeruginosa, A. niger, and C. albicans, respectively, when used alone.{37117} MIC values are 7 to 200-fold lower when MI is used in combination with MCI. MI decreases neurite outgrowth of rat cortical neurons when used at concentrations of 0.1-3 µM and inhibits Src family kinases in cell-free assays.{37116} MI, alone and as a mixture with MCI, can elicit contact sensitization.{30031}
Brand:CaymanSKU:28136 - 1 mlAvailable on backorder
Methylisothiazolinone (MI) is an isothiazolinone-derived biocide used for controlling microbial growth in industrial and household products, often in a mixture with 5-chloro-2-methyl-3-isothiazolone (MCI).{37117,30031} MI is active against Gram-positive and Gram-negative bacteria, fungi, and yeast with MIC values of 0.0045, 0.0015, >0.01, and 0.0065% (w/w) for S. aureus, P. aeruginosa, A. niger, and C. albicans, respectively, when used alone.{37117} MIC values are 7 to 200-fold lower when MI is used in combination with MCI. MI decreases neurite outgrowth of rat cortical neurons when used at concentrations of 0.1-3 µM and inhibits Src family kinases in cell-free assays.{37116} MI, alone and as a mixture with MCI, can elicit contact sensitization.{30031}
Brand:CaymanSKU:28136 - 10 mlAvailable on backorder
Methylisothiazolinone (MI) is an isothiazolinone-derived biocide used for controlling microbial growth in industrial and household products, often in a mixture with 5-chloro-2-methyl-3-isothiazolone (MCI).{37117,30031} MI is active against Gram-positive and Gram-negative bacteria, fungi, and yeast with MIC values of 0.0045, 0.0015, >0.01, and 0.0065% (w/w) for S. aureus, P. aeruginosa, A. niger, and C. albicans, respectively, when used alone.{37117} MIC values are 7 to 200-fold lower when MI is used in combination with MCI. MI decreases neurite outgrowth of rat cortical neurons when used at concentrations of 0.1-3 µM and inhibits Src family kinases in cell-free assays.{37116} MI, alone and as a mixture with MCI, can elicit contact sensitization.{30031}
Brand:CaymanSKU:28136 - 25 mlAvailable on backorder
Methylisothiazolinone (MI) is an isothiazolinone-derived biocide used for controlling microbial growth in industrial and household products, often in a mixture with 5-chloro-2-methyl-3-isothiazolone (MCI).{37117,30031} MI is active against Gram-positive and Gram-negative bacteria, fungi, and yeast with MIC values of 0.0045, 0.0015, >0.01, and 0.0065% (w/w) for S. aureus, P. aeruginosa, A. niger, and C. albicans, respectively, when used alone.{37117} MIC values are 7 to 200-fold lower when MI is used in combination with MCI. MI decreases neurite outgrowth of rat cortical neurons when used at concentrations of 0.1-3 µM and inhibits Src family kinases in cell-free assays.{37116} MI, alone and as a mixture with MCI, can elicit contact sensitization.{30031}
Brand:CaymanSKU:28136 - 5 mlAvailable on backorder
Methyllycaconitine (MLA) is an antagonist of α7-containing neuronal nicotinic acetylcholine receptors (nAChRs; Ki = 1.4 nM).{29719,33286} It is less effective at other nAChRs.{27173,27178} MLA is used to selectively evaluate the role of α7-containing nAChRs in signaling pathways.{33284,33285}
Brand:CaymanSKU:21398 -Out of stock
Methyllycaconitine (MLA) is an antagonist of α7-containing neuronal nicotinic acetylcholine receptors (nAChRs; Ki = 1.4 nM).{29719,33286} It is less effective at other nAChRs.{27173,27178} MLA is used to selectively evaluate the role of α7-containing nAChRs in signaling pathways.{33284,33285}
Brand:CaymanSKU:21398 -Out of stock
Methyllycaconitine (MLA) is an antagonist of α7-containing neuronal nicotinic acetylcholine receptors (nAChRs; Ki = 1.4 nM).{29719,33286} It is less effective at other nAChRs.{27173,27178} MLA is used to selectively evaluate the role of α7-containing nAChRs in signaling pathways.{33284,33285}
Brand:CaymanSKU:21398 -Out of stock
Methyllycaconitine (MLA) is an antagonist of α7-containing neuronal nicotinic acetylcholine receptors (nAChRs; Ki = 1.4 nM).{29719,33286} It is less effective at other nAChRs.{27173,27178} MLA is used to selectively evaluate the role of α7-containing nAChRs in signaling pathways.{33284,33285}
Brand:CaymanSKU:21398 -Out of stock
Methylmalonate (MMA) is a dicarboxylic acid that can be derived from methylmalonyl-coenzyme A (methylmalonyl-CoA), which is converted to succinyl-CoA in an enzymatic reaction that requires vitamin B12 (Item No. 18425). A deficiency in vitamin B12 prevents the normal conversion of methylmalonyl-CoA to succinyl-CoA, resulting in increased levels of MMA in the plasma and urine.{32689} Inherited metabolic disorders that prevent the metabolism of methylmalonyl-CoA can also result in elevated MMA levels.{32689} Excess MMA produces an acidemia that can interfere with normal neurological development.{32687,32688}
Brand:CaymanSKU:- Methylmalonate (MMA) is a dicarboxylic acid that can be derived from methylmalonyl-coenzyme A (methylmalonyl-CoA), which is converted to succinyl-CoA in an enzymatic reaction that requires vitamin B12 (Item No. 18425). A deficiency in vitamin B12 prevents the normal conversion of methylmalonyl-CoA to succinyl-CoA, resulting in increased levels of MMA in the plasma and urine.{32689} Inherited metabolic disorders that prevent the metabolism of methylmalonyl-CoA can also result in elevated MMA levels.{32689} Excess MMA produces an acidemia that can interfere with normal neurological development.{32687,32688}
Brand:CaymanSKU:- Methylmalonate (MMA) is a dicarboxylic acid that can be derived from methylmalonyl-coenzyme A (methylmalonyl-CoA), which is converted to succinyl-CoA in an enzymatic reaction that requires vitamin B12 (Item No. 18425). A deficiency in vitamin B12 prevents the normal conversion of methylmalonyl-CoA to succinyl-CoA, resulting in increased levels of MMA in the plasma and urine.{32689} Inherited metabolic disorders that prevent the metabolism of methylmalonyl-CoA can also result in elevated MMA levels.{32689} Excess MMA produces an acidemia that can interfere with normal neurological development.{32687,32688}
Brand:CaymanSKU:- Methylmalonate (MMA) is a dicarboxylic acid that can be derived from methylmalonyl-coenzyme A (methylmalonyl-CoA), which is converted to succinyl-CoA in an enzymatic reaction that requires vitamin B12 (Item No. 18425). A deficiency in vitamin B12 prevents the normal conversion of methylmalonyl-CoA to succinyl-CoA, resulting in increased levels of MMA in the plasma and urine.{32689} Inherited metabolic disorders that prevent the metabolism of methylmalonyl-CoA can also result in elevated MMA levels.{32689} Excess MMA produces an acidemia that can interfere with normal neurological development.{32687,32688}
Brand:CaymanSKU:-