Cayman
Showing 28801–28950 of 45550 results
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Meconin, a noscapine metabolite, is a urinary detection marker for illicit opiate misuse. This product is intended for use as a forensic standard.{20439}
Brand:CaymanSKU:9001140 - 50 mgAvailable on backorder
Meconin-d3 contains three deuterium atoms. It is intended for use as an internal standard for the quantification of meconin by GC- or LC-mass spectrometry. Meconin, a noscapine metabolite, is a urinary detection marker for illicit opiate misuse. This product is intended for use as a forensic standard.{20439}
Brand:CaymanSKU:9001141 - 1 mgAvailable on backorder
Meconin-d3 contains three deuterium atoms. It is intended for use as an internal standard for the quantification of meconin by GC- or LC-mass spectrometry. Meconin, a noscapine metabolite, is a urinary detection marker for illicit opiate misuse. This product is intended for use as a forensic standard.{20439}
Brand:CaymanSKU:9001141 - 10 mgAvailable on backorder
Meconin-d3 contains three deuterium atoms. It is intended for use as an internal standard for the quantification of meconin by GC- or LC-mass spectrometry. Meconin, a noscapine metabolite, is a urinary detection marker for illicit opiate misuse. This product is intended for use as a forensic standard.{20439}
Brand:CaymanSKU:9001141 - 5 mgAvailable on backorder
DNA methylation, or the addition of methyl groups to cytosine bases in the dinucleotide CpG, is imperative to proper development and regulates gene expression. The methylation pattern involves the enzymatic processes of methylation and demethylation. A demethylase enzyme has been identified which exhibits demethylase activity associated to a methyl-CpG-binding domain (MBD).{17997} The enzyme is able to revert methylated cytosine bases to cytosines within the particular dinucleotide sequence mdCpdG by catalyzing the cleaving of the methyl group as methanol. MeCP2 and MBD1 (PCM1) repress transcription by binding specifically to methylated DNA.{17999} MBD2 and MBD4 (also known as MED1) colocalize with foci of heavily methylated satellite DNA and mediate the biological functions of the methylation signal. Surprisingly, MBD3 does not bind methylated DNA either in vivo or in vitro. MeCP2, MBD1, MBD2, MBD3, and MBD4 are expressed in somatic tissues, but the expression of MBD1 and MBD2 is reduced or absent in embryonic stem cells, which are known to be deficient in MeCP1 activity. MBD4 has homology to bacterial base excision repair DNA N-glycosylases/lyases.{17996} In some microsatellite unstable tumors MBD4 is mutated at an exonic polynucleotide tract.{17995}
Brand:CaymanSKU:13775 - 1 eaAvailable on backorder
Antigen: a mixture of synthetic peptides corresponding two amino acids 268-282 and 337-352 of human MBD4 • Host: rabbit • Cross Reactivity: (+) human MBD4 • Application(s): ICC, IHC, and WB • MeCP2 may function as a mediator of the biological consequences of the methylation signal. It is also reported that this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing.
Brand:CaymanSKU:13775- 1 eaAvailable on backorder
Antigen: a mixture of synthetic peptides corresponding two amino acids 268-282 and 337-352 of human MBD4 • Host: rabbit • Cross Reactivity: (+) human MBD4 • Application(s): ICC, IHC, and WB • MeCP2 may function as a mediator of the biological consequences of the methylation signal. It is also reported that this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing.
Brand:CaymanSKU:13775- 1 ea
Medetomidine is an imidazole derivative that acts as a selective agonist of α2-adrenoceptors (Ki = 1.08 nM vs. 1750 nM for α1-adrenoceptors).{26978,25422} Medetomidine is a mixture of D and L isomers, with the D form, known as dexmedetomidine (Item No. 15581), described as the active form. Through its effect on α2-adrenoceptors, medetomidine has sedative, antinociceptive, analgesic, and hypothermic actions.{26974,26980} Its effects on pain are additive or synergistic with fentanyl-type opioids.{26977,26976} The effects of medetomidine are effectively countered by α2-adrenoceptor antagonists, like atipamezole.{26979} Selective α2-adrenoceptor agonists, including medetomidine, have anesthetic sparing properties, greatly reducing the dose of anesthetic required following premedication with the α2-adrenoceptor agonist.{26980}
Brand:CaymanSKU:-Out of stock
Medetomidine is an imidazole derivative that acts as a selective agonist of α2-adrenoceptors (Ki = 1.08 nM vs. 1750 nM for α1-adrenoceptors).{26978,25422} Medetomidine is a mixture of D and L isomers, with the D form, known as dexmedetomidine (Item No. 15581), described as the active form. Through its effect on α2-adrenoceptors, medetomidine has sedative, antinociceptive, analgesic, and hypothermic actions.{26974,26980} Its effects on pain are additive or synergistic with fentanyl-type opioids.{26977,26976} The effects of medetomidine are effectively countered by α2-adrenoceptor antagonists, like atipamezole.{26979} Selective α2-adrenoceptor agonists, including medetomidine, have anesthetic sparing properties, greatly reducing the dose of anesthetic required following premedication with the α2-adrenoceptor agonist.{26980}
Brand:CaymanSKU:-Out of stock
Medetomidine is an imidazole derivative that acts as a selective agonist of α2-adrenoceptors (Ki = 1.08 nM vs. 1750 nM for α1-adrenoceptors).{26978,25422} Medetomidine is a mixture of D and L isomers, with the D form, known as dexmedetomidine (Item No. 15581), described as the active form. Through its effect on α2-adrenoceptors, medetomidine has sedative, antinociceptive, analgesic, and hypothermic actions.{26974,26980} Its effects on pain are additive or synergistic with fentanyl-type opioids.{26977,26976} The effects of medetomidine are effectively countered by α2-adrenoceptor antagonists, like atipamezole.{26979} Selective α2-adrenoceptor agonists, including medetomidine, have anesthetic sparing properties, greatly reducing the dose of anesthetic required following premedication with the α2-adrenoceptor agonist.{26980}
Brand:CaymanSKU:-Out of stock
Medetomidine-13C-d3 is intended for use as an internal standard for the quantification of medetomidine by GC- or LC-MS. Medetomidine is an imidazole compound that selectively binds to α2-adrenergic receptors (α2-ARs) over α1-ARs (Kis = 1.08 and 1,800 nM, respectively).{25422}
Brand:CaymanSKU:25041 - 1 mgAvailable on backorder
MEDICA 16 is a β,β’-dimethyl hexadecanedioic acid which exhibits hypolipidemic and antidiabetogenic effects in the rat. In animals that were fed a diet which was 0.25% MEDICA 16 by weight, the hypolipidemic effect consisted of a 70-80% decrease in plasma chylomicrons and VLDL-triacylglycerols as well as a 40-60% decrease in plasma VLDL-cholestrol.{3039}
Brand:CaymanSKU:90290 - 1 mgAvailable on backorder
MEDICA 16 is a β,β’-dimethyl hexadecanedioic acid which exhibits hypolipidemic and antidiabetogenic effects in the rat. In animals that were fed a diet which was 0.25% MEDICA 16 by weight, the hypolipidemic effect consisted of a 70-80% decrease in plasma chylomicrons and VLDL-triacylglycerols as well as a 40-60% decrease in plasma VLDL-cholestrol.{3039}
Brand:CaymanSKU:90290 - 10 mgAvailable on backorder
MEDICA 16 is a β,β’-dimethyl hexadecanedioic acid which exhibits hypolipidemic and antidiabetogenic effects in the rat. In animals that were fed a diet which was 0.25% MEDICA 16 by weight, the hypolipidemic effect consisted of a 70-80% decrease in plasma chylomicrons and VLDL-triacylglycerols as well as a 40-60% decrease in plasma VLDL-cholestrol.{3039}
Brand:CaymanSKU:90290 - 5 mgAvailable on backorder
MEDICA 16 is a β,β’-dimethyl hexadecanedioic acid which exhibits hypolipidemic and antidiabetogenic effects in the rat. In animals that were fed a diet which was 0.25% MEDICA 16 by weight, the hypolipidemic effect consisted of a 70-80% decrease in plasma chylomicrons and VLDL-triacylglycerols as well as a 40-60% decrease in plasma VLDL-cholestrol.{3039}
Brand:CaymanSKU:90290 - 50 mgAvailable on backorder
Medroxyprogesterone is a progesterone receptor agonist (Ki = 241 nM) and a metabolite of medroxyprogesterone 17-acetate (Item No. 23664).{42538,42539,42540} It induces a conformational change in the C-terminal domain of the progesterone receptor (EC50 = 47.3 nM) and increases alkaline phosphatase activity in T47D breast cancer cells (EC50 = 23 nM).{42538}
Brand:CaymanSKU:24908 - 1 gAvailable on backorder
Medroxyprogesterone is a progesterone receptor agonist (Ki = 241 nM) and a metabolite of medroxyprogesterone 17-acetate (Item No. 23664).{42538,42539,42540} It induces a conformational change in the C-terminal domain of the progesterone receptor (EC50 = 47.3 nM) and increases alkaline phosphatase activity in T47D breast cancer cells (EC50 = 23 nM).{42538}
Brand:CaymanSKU:24908 - 100 mgAvailable on backorder
Medroxyprogesterone is a progesterone receptor agonist (Ki = 241 nM) and a metabolite of medroxyprogesterone 17-acetate (Item No. 23664).{42538,42539,42540} It induces a conformational change in the C-terminal domain of the progesterone receptor (EC50 = 47.3 nM) and increases alkaline phosphatase activity in T47D breast cancer cells (EC50 = 23 nM).{42538}
Brand:CaymanSKU:24908 - 500 mgAvailable on backorder
Medroxyprogesterone 17-acetate is a synthetic progestogen.{37205},{37206},{37207} It prevents fertilization and increases the rate of transport of eggs from the fallopian tubes to the uterus in female ferrets when administered prior to ovulation.{37205} Medroxyprogesterone 17-acetate reversibly blocks ovulation in rats when injected on the last day of diestrus.{37206} It also has anti-androgenic activity in rats, decreasing plasma testosterone (Item Nos. 15645 | ISO60154) levels via induction of hepatic testosterone reductase activity.{37207} Medroxyprogesterone 17-acetate exhibits immunosuppressive effects in vitro and in vivo, inhibiting the production of IFN-γ by CD2/CD3/CD28-stimulated peripheral blood mononuclear cells (PBMCs) at concentrations ≥10 nM and extending the survival of rabbit skin allografts.{37208},{37209} Injectable formulations containing medroxyprogesterone 17-acetate have been used as contraceptives.{37210}
Brand:CaymanSKU:23664 - 1 gAvailable on backorder
Medroxyprogesterone 17-acetate is a synthetic progestogen.{37205},{37206},{37207} It prevents fertilization and increases the rate of transport of eggs from the fallopian tubes to the uterus in female ferrets when administered prior to ovulation.{37205} Medroxyprogesterone 17-acetate reversibly blocks ovulation in rats when injected on the last day of diestrus.{37206} It also has anti-androgenic activity in rats, decreasing plasma testosterone (Item Nos. 15645 | ISO60154) levels via induction of hepatic testosterone reductase activity.{37207} Medroxyprogesterone 17-acetate exhibits immunosuppressive effects in vitro and in vivo, inhibiting the production of IFN-γ by CD2/CD3/CD28-stimulated peripheral blood mononuclear cells (PBMCs) at concentrations ≥10 nM and extending the survival of rabbit skin allografts.{37208},{37209} Injectable formulations containing medroxyprogesterone 17-acetate have been used as contraceptives.{37210}
Brand:CaymanSKU:23664 - 500 mgAvailable on backorder
Mefenamic acid is a non-steroidal anti-inflammatory drug (NSAID) and a COX-2 inhibitor.{41197} It binds to COX-2 (Kd = 4 nM) and inhibits COX-2-dependent oxygenation of arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) in vitro (Ki = 10 µM). Mefenamic acid (30 mg/kg) reduces acetic acid-induced writhing in rats.{41198} It inhibits increases in skin thickness in a mouse model of delayed-type hypersensitivity induced by dinitrochlorobenzene (DNBC).{41198} Mefenamic acid also reduces the antibody response to sheep red blood cells in mice.
Brand:CaymanSKU:23650 - 100 mgAvailable on backorder
Mefenamic acid is a non-steroidal anti-inflammatory drug (NSAID) and a COX-2 inhibitor.{41197} It binds to COX-2 (Kd = 4 nM) and inhibits COX-2-dependent oxygenation of arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) in vitro (Ki = 10 µM). Mefenamic acid (30 mg/kg) reduces acetic acid-induced writhing in rats.{41198} It inhibits increases in skin thickness in a mouse model of delayed-type hypersensitivity induced by dinitrochlorobenzene (DNBC).{41198} Mefenamic acid also reduces the antibody response to sheep red blood cells in mice.
Brand:CaymanSKU:23650 - 25 mgAvailable on backorder
Mefenamic acid is a non-steroidal anti-inflammatory drug (NSAID) and a COX-2 inhibitor.{41197} It binds to COX-2 (Kd = 4 nM) and inhibits COX-2-dependent oxygenation of arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) in vitro (Ki = 10 µM). Mefenamic acid (30 mg/kg) reduces acetic acid-induced writhing in rats.{41198} It inhibits increases in skin thickness in a mouse model of delayed-type hypersensitivity induced by dinitrochlorobenzene (DNBC).{41198} Mefenamic acid also reduces the antibody response to sheep red blood cells in mice.
Brand:CaymanSKU:23650 - 50 mgAvailable on backorder
Mefenamic acid is a non-steroidal anti-inflammatory drug (NSAID) and a COX-2 inhibitor.{41197} It binds to COX-2 (Kd = 4 nM) and inhibits COX-2-dependent oxygenation of arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) in vitro (Ki = 10 µM). Mefenamic acid (30 mg/kg) reduces acetic acid-induced writhing in rats.{41198} It inhibits increases in skin thickness in a mouse model of delayed-type hypersensitivity induced by dinitrochlorobenzene (DNBC).{41198} Mefenamic acid also reduces the antibody response to sheep red blood cells in mice.
Brand:CaymanSKU:23650 - 500 mgAvailable on backorder
Mefenamic acid-d4 is intended for use as an internal standard for the quantification of mefenamic acid (Item No. 23650) by GC- or LC-MS. Mefenamic acid is a non-steroidal anti-inflammatory drug (NSAID) and a COX-2 inhibitor.{41197} It binds to COX-2 (Kd = 4 nM) and inhibits COX-2-dependent oxygenation of arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) in vitro (Ki = 10 µM). Mefenamic acid (30 mg/kg) reduces acetic acid-induced writhing in rats.{41198} It inhibits increases in skin thickness in a mouse model of delayed-type hypersensitivity induced by dinitrochlorobenzene (DNBC).{41198} Mefenamic acid also reduces the antibody response to sheep red blood cells in mice.
Brand:CaymanSKU:31788 - 1 mgAvailable on backorder
Mefloquine is an orally bioavailable quinolinemethanol derivative with antimalarial properties.{38380} It increases mean survival time and abolishes malarial infection in mice at doses of 10 and 40 mg/kg, respectively. It inhibits hemozoin formation, leading to an increase in free heme in purified trophozoites.{38381} It acts as an antagonist at the adenosine A2A receptor, an agonist at serotonin 5-HT2A and 5-HT2C receptors, and has various effects on calcium homeostasis.{38382,38383} Mefloquine increases the time mice spend in the light side of the light-dark box test and reduces immobility time in the tail suspension test, parameters typically associated with anxiolytic and antidepressant-like behavior.{38383} Formulations containing mefloquine have been used to prevent and treat malaria but have been associated with neuropsychiatric disturbances.
Brand:CaymanSKU:23665 - 100 mgAvailable on backorder
Mefloquine is an orally bioavailable quinolinemethanol derivative with antimalarial properties.{38380} It increases mean survival time and abolishes malarial infection in mice at doses of 10 and 40 mg/kg, respectively. It inhibits hemozoin formation, leading to an increase in free heme in purified trophozoites.{38381} It acts as an antagonist at the adenosine A2A receptor, an agonist at serotonin 5-HT2A and 5-HT2C receptors, and has various effects on calcium homeostasis.{38382,38383} Mefloquine increases the time mice spend in the light side of the light-dark box test and reduces immobility time in the tail suspension test, parameters typically associated with anxiolytic and antidepressant-like behavior.{38383} Formulations containing mefloquine have been used to prevent and treat malaria but have been associated with neuropsychiatric disturbances.
Brand:CaymanSKU:23665 - 250 mgAvailable on backorder
Mefloquine is an orally bioavailable quinolinemethanol derivative with antimalarial properties.{38380} It increases mean survival time and abolishes malarial infection in mice at doses of 10 and 40 mg/kg, respectively. It inhibits hemozoin formation, leading to an increase in free heme in purified trophozoites.{38381} It acts as an antagonist at the adenosine A2A receptor, an agonist at serotonin 5-HT2A and 5-HT2C receptors, and has various effects on calcium homeostasis.{38382,38383} Mefloquine increases the time mice spend in the light side of the light-dark box test and reduces immobility time in the tail suspension test, parameters typically associated with anxiolytic and antidepressant-like behavior.{38383} Formulations containing mefloquine have been used to prevent and treat malaria but have been associated with neuropsychiatric disturbances.
Brand:CaymanSKU:23665 - 50 mgAvailable on backorder
Mefloquine is an orally bioavailable quinolinemethanol derivative with antimalarial properties.{38380} It increases mean survival time and abolishes malarial infection in mice at doses of 10 and 40 mg/kg, respectively. It inhibits hemozoin formation, leading to an increase in free heme in purified trophozoites.{38381} It acts as an antagonist at the adenosine A2A receptor, an agonist at serotonin 5-HT2A and 5-HT2C receptors, and has various effects on calcium homeostasis.{38382,38383} Mefloquine increases the time mice spend in the light side of the light-dark box test and reduces immobility time in the tail suspension test, parameters typically associated with anxiolytic and antidepressant-like behavior.{38383} Formulations containing mefloquine have been used to prevent and treat malaria but have been associated with neuropsychiatric disturbances.
Brand:CaymanSKU:23665 - 500 mgAvailable on backorder
MEG is a selective iNOS inhibitor and scavenger of peroxynitrite. The EC50 values for inhibition of iNOS (LPS-treated rat lung), eNOS (bovine endothelial), and nNOS (rat brain) are 11.5, 110, and 60 µM, respectively.{7417} MEG reacts with peroxynitrite with a second order rate constant of 1,900 M−1s−1 at 37°C.{4278} MEG has potent anti-inflammatory activity, which may be due to the combined effect of MEG acting as an inhibitor of iNOS and as a scavenger of peroxynitrite.{5922}
Brand:CaymanSKU:81020 - 10 mgAvailable on backorder
MEG is a selective iNOS inhibitor and scavenger of peroxynitrite. The EC50 values for inhibition of iNOS (LPS-treated rat lung), eNOS (bovine endothelial), and nNOS (rat brain) are 11.5, 110, and 60 µM, respectively.{7417} MEG reacts with peroxynitrite with a second order rate constant of 1,900 M−1s−1 at 37°C.{4278} MEG has potent anti-inflammatory activity, which may be due to the combined effect of MEG acting as an inhibitor of iNOS and as a scavenger of peroxynitrite.{5922}
Brand:CaymanSKU:81020 - 100 mgAvailable on backorder
MEG is a selective iNOS inhibitor and scavenger of peroxynitrite. The EC50 values for inhibition of iNOS (LPS-treated rat lung), eNOS (bovine endothelial), and nNOS (rat brain) are 11.5, 110, and 60 µM, respectively.{7417} MEG reacts with peroxynitrite with a second order rate constant of 1,900 M−1s−1 at 37°C.{4278} MEG has potent anti-inflammatory activity, which may be due to the combined effect of MEG acting as an inhibitor of iNOS and as a scavenger of peroxynitrite.{5922}
Brand:CaymanSKU:81020 - 5 mgAvailable on backorder
MEG is a selective iNOS inhibitor and scavenger of peroxynitrite. The EC50 values for inhibition of iNOS (LPS-treated rat lung), eNOS (bovine endothelial), and nNOS (rat brain) are 11.5, 110, and 60 µM, respectively.{7417} MEG reacts with peroxynitrite with a second order rate constant of 1,900 M−1s−1 at 37°C.{4278} MEG has potent anti-inflammatory activity, which may be due to the combined effect of MEG acting as an inhibitor of iNOS and as a scavenger of peroxynitrite.{5922}
Brand:CaymanSKU:81020 - 50 mgAvailable on backorder
MEGA-10 is a nonionic detergent that can be used to solubilize membrane proteins.{48034} It has a critical micelle concentration (CMC) of 4.88 mM under no salt conditions, which decreases in the presence of sodium chloride.{48035} MEGA-10 has been used to reconstitute amino acid transporters from rat liver plasma membrane vesicles into artificial phospholipid membranes.{48036} It has also been used to solubilize the melibiose transport carrier from E. coli membranes and reconstitute it into liposomes.{48037}
Brand:CaymanSKU:25703 - 1 gAvailable on backorder
MEGA-10 is a nonionic detergent that can be used to solubilize membrane proteins.{48034} It has a critical micelle concentration (CMC) of 4.88 mM under no salt conditions, which decreases in the presence of sodium chloride.{48035} MEGA-10 has been used to reconstitute amino acid transporters from rat liver plasma membrane vesicles into artificial phospholipid membranes.{48036} It has also been used to solubilize the melibiose transport carrier from E. coli membranes and reconstitute it into liposomes.{48037}
Brand:CaymanSKU:25703 - 5 gAvailable on backorder
MEGA-10 is a nonionic detergent that can be used to solubilize membrane proteins.{48034} It has a critical micelle concentration (CMC) of 4.88 mM under no salt conditions, which decreases in the presence of sodium chloride.{48035} MEGA-10 has been used to reconstitute amino acid transporters from rat liver plasma membrane vesicles into artificial phospholipid membranes.{48036} It has also been used to solubilize the melibiose transport carrier from E. coli membranes and reconstitute it into liposomes.{48037}
Brand:CaymanSKU:25703 - 500 mgAvailable on backorder
MEGA-8 is a nonionic detergent that can be used to solubilize membrane proteins.{48031} It has a critical micelle concentration (CMC) of 70 mM under no-salt conditions and CMCs ranging from 5 to 64 mM under high and low salt conditions for a variety of salts.{48032}
Brand:CaymanSKU:25701 - 1 gAvailable on backorder
MEGA-8 is a nonionic detergent that can be used to solubilize membrane proteins.{48031} It has a critical micelle concentration (CMC) of 70 mM under no-salt conditions and CMCs ranging from 5 to 64 mM under high and low salt conditions for a variety of salts.{48032}
Brand:CaymanSKU:25701 - 10 gAvailable on backorder
MEGA-8 is a nonionic detergent that can be used to solubilize membrane proteins.{48031} It has a critical micelle concentration (CMC) of 70 mM under no-salt conditions and CMCs ranging from 5 to 64 mM under high and low salt conditions for a variety of salts.{48032}
Brand:CaymanSKU:25701 - 25 gAvailable on backorder
MEGA-8 is a nonionic detergent that can be used to solubilize membrane proteins.{48031} It has a critical micelle concentration (CMC) of 70 mM under no-salt conditions and CMCs ranging from 5 to 64 mM under high and low salt conditions for a variety of salts.{48032}
Brand:CaymanSKU:25701 - 5 gAvailable on backorder
MEGA-9 is a nonionic detergent that can be used to solubilize membrane proteins.{48034} It has a critical micelle concentration (CMC) of 20 mM under no-salt conditions and CMCs ranging from 2 to 17.1 mM under high and low salt conditions for a variety of salts.{48032} It has been used to solubilize the melibiose transport carrier from E. coli membranes and reconstitute it into liposomes.{48037}
Brand:CaymanSKU:25702 - 1 gAvailable on backorder
MEGA-9 is a nonionic detergent that can be used to solubilize membrane proteins.{48034} It has a critical micelle concentration (CMC) of 20 mM under no-salt conditions and CMCs ranging from 2 to 17.1 mM under high and low salt conditions for a variety of salts.{48032} It has been used to solubilize the melibiose transport carrier from E. coli membranes and reconstitute it into liposomes.{48037}
Brand:CaymanSKU:25702 - 10 gAvailable on backorder
MEGA-9 is a nonionic detergent that can be used to solubilize membrane proteins.{48034} It has a critical micelle concentration (CMC) of 20 mM under no-salt conditions and CMCs ranging from 2 to 17.1 mM under high and low salt conditions for a variety of salts.{48032} It has been used to solubilize the melibiose transport carrier from E. coli membranes and reconstitute it into liposomes.{48037}
Brand:CaymanSKU:25702 - 5 gAvailable on backorder
MEGA-9 is a nonionic detergent that can be used to solubilize membrane proteins.{48034} It has a critical micelle concentration (CMC) of 20 mM under no-salt conditions and CMCs ranging from 2 to 17.1 mM under high and low salt conditions for a variety of salts.{48032} It has been used to solubilize the melibiose transport carrier from E. coli membranes and reconstitute it into liposomes.{48037}
Brand:CaymanSKU:25702 - 500 mgAvailable on backorder
Megestryl acetate is a synthetic progestogen and derivative of progesterone originally developed as a contraceptive.{38302} It binds with high relative affinity to the progesterone (Item No. 15876), androgen, and glucocorticoid receptors in mammary cancer cells.{38303} It increases neuropeptide Y (Item No. 15071) by 90-140% and inhibits calcium channel currents in the rat hypothalamus.{38301,38299} Megestryl acetate decreases cytokine and serotonin production in patient-derived peripheral blood mononuclear cells (PBMCs).{38300} In rats, it increases food and water intake when administered at a dose of 50 mg/kg per day.{38301} Formulations containing megestryl acetate have been used in the treatment of endometriosis, hormone-related cancers, and as an appetite stimulant for cancer patients with anorexia and cachexia.{38304}
Brand:CaymanSKU:21749 -Out of stock
Megestryl acetate is a synthetic progestogen and derivative of progesterone originally developed as a contraceptive.{38302} It binds with high relative affinity to the progesterone (Item No. 15876), androgen, and glucocorticoid receptors in mammary cancer cells.{38303} It increases neuropeptide Y (Item No. 15071) by 90-140% and inhibits calcium channel currents in the rat hypothalamus.{38301,38299} Megestryl acetate decreases cytokine and serotonin production in patient-derived peripheral blood mononuclear cells (PBMCs).{38300} In rats, it increases food and water intake when administered at a dose of 50 mg/kg per day.{38301} Formulations containing megestryl acetate have been used in the treatment of endometriosis, hormone-related cancers, and as an appetite stimulant for cancer patients with anorexia and cachexia.{38304}
Brand:CaymanSKU:21749 -Out of stock
MEGX is an active metabolite of lidocaine.{42862} It is formed via N-deethylation of lidocaine by the hepatic cytochrome P450 (CYP) isoform CYP3A4. Topical administration of MEGX (2% v/v) reduces thrombus formation in a hamster model of laser-induced microvascular injury.{42863} Plasma levels of MEGX following lidocaine administration have been used to monitor declining liver function in patients with cirrhosis.{42862}
Brand:CaymanSKU:28019 - 1 mgAvailable on backorder
MEGX is an active metabolite of lidocaine.{42862} It is formed via N-deethylation of lidocaine by the hepatic cytochrome P450 (CYP) isoform CYP3A4. Topical administration of MEGX (2% v/v) reduces thrombus formation in a hamster model of laser-induced microvascular injury.{42863} Plasma levels of MEGX following lidocaine administration have been used to monitor declining liver function in patients with cirrhosis.{42862}
Brand:CaymanSKU:28019 - 10 mgAvailable on backorder
MEGX is an active metabolite of lidocaine.{42862} It is formed via N-deethylation of lidocaine by the hepatic cytochrome P450 (CYP) isoform CYP3A4. Topical administration of MEGX (2% v/v) reduces thrombus formation in a hamster model of laser-induced microvascular injury.{42863} Plasma levels of MEGX following lidocaine administration have been used to monitor declining liver function in patients with cirrhosis.{42862}
Brand:CaymanSKU:28019 - 25 mgAvailable on backorder
MEGX is an active metabolite of lidocaine.{42862} It is formed via N-deethylation of lidocaine by the hepatic cytochrome P450 (CYP) isoform CYP3A4. Topical administration of MEGX (2% v/v) reduces thrombus formation in a hamster model of laser-induced microvascular injury.{42863} Plasma levels of MEGX following lidocaine administration have been used to monitor declining liver function in patients with cirrhosis.{42862}
Brand:CaymanSKU:28019 - 5 mgAvailable on backorder
Meisoindigo is a derivative of indirubin (Item No. 14155) that has anticancer activity.{41774} It inhibits the growth of NB4, HL-60, and U937 leukemia and primary acute myeloid leukemia (AML) cells when used at concentrations of 5 and 10 µM. It also halts the cell cycle at the G0/G1 phase and induces apoptosis in leukemia cell lines and primary AML cells, induces myeloid differentiation, and potentiates the effects of cytarabine (Item No. 16069) and idarubicin (Item No. 14176). Meisoindigo (10 µM) also induces apoptosis, decreases adherence, and decreases the expression of vascular cell adhesion molecule-1 (VCAM-1) in ECV304 human vein endothelial cells.{41775} Meisoindigo (50-150 mg/kg per day) decreases spleen size in an HL-60 mouse xenograft model of AML in a dose-dependent manner.
Brand:CaymanSKU:-Available on backorder
Meisoindigo is a derivative of indirubin (Item No. 14155) that has anticancer activity.{41774} It inhibits the growth of NB4, HL-60, and U937 leukemia and primary acute myeloid leukemia (AML) cells when used at concentrations of 5 and 10 µM. It also halts the cell cycle at the G0/G1 phase and induces apoptosis in leukemia cell lines and primary AML cells, induces myeloid differentiation, and potentiates the effects of cytarabine (Item No. 16069) and idarubicin (Item No. 14176). Meisoindigo (10 µM) also induces apoptosis, decreases adherence, and decreases the expression of vascular cell adhesion molecule-1 (VCAM-1) in ECV304 human vein endothelial cells.{41775} Meisoindigo (50-150 mg/kg per day) decreases spleen size in an HL-60 mouse xenograft model of AML in a dose-dependent manner.
Brand:CaymanSKU:-Available on backorder
Meisoindigo is a derivative of indirubin (Item No. 14155) that has anticancer activity.{41774} It inhibits the growth of NB4, HL-60, and U937 leukemia and primary acute myeloid leukemia (AML) cells when used at concentrations of 5 and 10 µM. It also halts the cell cycle at the G0/G1 phase and induces apoptosis in leukemia cell lines and primary AML cells, induces myeloid differentiation, and potentiates the effects of cytarabine (Item No. 16069) and idarubicin (Item No. 14176). Meisoindigo (10 µM) also induces apoptosis, decreases adherence, and decreases the expression of vascular cell adhesion molecule-1 (VCAM-1) in ECV304 human vein endothelial cells.{41775} Meisoindigo (50-150 mg/kg per day) decreases spleen size in an HL-60 mouse xenograft model of AML in a dose-dependent manner.
Brand:CaymanSKU:-Available on backorder
Meisoindigo is a derivative of indirubin (Item No. 14155) that has anticancer activity.{41774} It inhibits the growth of NB4, HL-60, and U937 leukemia and primary acute myeloid leukemia (AML) cells when used at concentrations of 5 and 10 µM. It also halts the cell cycle at the G0/G1 phase and induces apoptosis in leukemia cell lines and primary AML cells, induces myeloid differentiation, and potentiates the effects of cytarabine (Item No. 16069) and idarubicin (Item No. 14176). Meisoindigo (10 µM) also induces apoptosis, decreases adherence, and decreases the expression of vascular cell adhesion molecule-1 (VCAM-1) in ECV304 human vein endothelial cells.{41775} Meisoindigo (50-150 mg/kg per day) decreases spleen size in an HL-60 mouse xenograft model of AML in a dose-dependent manner.
Brand:CaymanSKU:-Available on backorder
MAP kinase kinase 1 (MAPKK1) is an integral component of the MAP kinase cascade that regulates cell growth and differentiation {14328,14329}. This pathway also plays a key role in synaptic plasticity in the brain {14327}. Activated MEK1 acts as a dual specificity kinase phosphorylating both a threonine and a tyrosine residue on MAP kinase {14331,14332,14543}. Conversely, there also appears to be a feedback phosphorylation of MEK1 by MAP kinase. The sites on MEK1 that are phosphorylated by MAP kinase on Thr292 and Thr386 {14330}.
Brand:CaymanSKU:10009518 - 1 eaAvailable on backorder
Antigen: phosphopeptide corresponding to amino acid residues surrounding phospho-Thr292 of human MEK1 • Host: rabbit • Cross Reactivity: (+) human and rat MEK1; expected to react with bovine, canine, chicken, mouse, non-human primates, and Xenopus MEK1 • Application(s): WB • MEK1 is an integral component of the MAPK cascade that regulates cell growth and differentiation. MEK1 is phosphorylated by MAPK on Thr292 and Thr386.
Brand:CaymanSKU:10009518- 1 eaAvailable on backorder
Antigen: phosphopeptide corresponding to amino acid residues surrounding phospho-Thr292 of human MEK1 • Host: rabbit • Cross Reactivity: (+) human and rat MEK1; expected to react with bovine, canine, chicken, mouse, non-human primates, and Xenopus MEK1 • Application(s): WB • MEK1 is an integral component of the MAPK cascade that regulates cell growth and differentiation. MEK1 is phosphorylated by MAPK on Thr292 and Thr386.
Brand:CaymanSKU:10009518- 1 ea MAP kinase kinase 1 (MEK1) is an integral component of the MAP kinase cascade that regulates cell growth and differentiation {14328,14329}. This pathway also plays a key role in synaptic plasticity in the brain {14327}. Activated MEK1 acts as a dual specificity kinase phosphorylating both a threonine and a tyrosine residue on MAP kinase {14331,14332,14543}. Conversely, there also appears to be a feedback phosphorylation of MEK1 by MAP kinase. The sites on MEK1 that are phosphorylated by MAP kinase are Thr292 and Thr386 {14330}.
Brand:CaymanSKU:10009517 - 1 eaAvailable on backorder
Antigen: phosphopeptide corresponding to amino acid residues surrounding phospho-Thr386 of human MEK 1; expected to react with bovine, canine, chicken, mouse, non-human primates, and Xenopus MEK1 • Host: rabbit • Cross Reactivity: (+) rat MEK1 • Application(s): WB • MEK1 is an integral component of the MAPK cascade that regulates cell growth and differentiation. MEK1 is phosphorylated by MAPK on Thr292 and Thr386.
Brand:CaymanSKU:10009517- 1 eaAvailable on backorder
Antigen: phosphopeptide corresponding to amino acid residues surrounding phospho-Thr386 of human MEK 1; expected to react with bovine, canine, chicken, mouse, non-human primates, and Xenopus MEK1 • Host: rabbit • Cross Reactivity: (+) rat MEK1 • Application(s): WB • MEK1 is an integral component of the MAPK cascade that regulates cell growth and differentiation. MEK1 is phosphorylated by MAPK on Thr292 and Thr386.
Brand:CaymanSKU:10009517- 1 ea MAP kinase kinase 1 (MEK1) is an integral component of the MAP kinase cascade that regulates cell growth and differentiation.{14328,14329} This pathway also plays a key role in synaptic plasticity in the brain.{14327} Activated MEK1 acts as a dual specificity kinase phosphorylating both a threonine and a tyrosine residue on MAP kinase.{14330,14331,14332}
Brand:CaymanSKU:10009178 - 1 eaAvailable on backorder
Antigen: phosphopeptide corresponding to amino acid residues surrounding phospho-Ser218,222 of human MEK1/2 • Host: rabbit • Cross Reactivity: (+) NIH 3T3 cells • Application(s): WB • MEK1 is an integral component of the MAPK cascade that regulates cell growth and differentiation.
Brand:CaymanSKU:10009178- 1 eaAvailable on backorder
Antigen: phosphopeptide corresponding to amino acid residues surrounding phospho-Ser218,222 of human MEK1/2 • Host: rabbit • Cross Reactivity: (+) NIH 3T3 cells • Application(s): WB • MEK1 is an integral component of the MAPK cascade that regulates cell growth and differentiation.
Brand:CaymanSKU:10009178- 1 ea Brand:CaymanSKU:600182 - 10 µlAvailable on backorder
The Melanocortin-3 receptor (MC3R) helps regulate energy homeostasis and mice lacking MC3R have increased fat mass and reduced lean mass. Therefore, agonists that selectively activate MC3R might have beneficial effects related to weight gain and glucose metabolism. This assay consists of a 96-well plate coated with a transfection complex containing DNA constructs for MC3R and a cAMP response element regulated Secreted Alkaline Phosphatase (SEAP) reporter (MC3R Reverse Transfection Strip Plate). Cells grown on the transfection complex will express MC3R at the cell surface. Binding of agonists to MC3R initiates a signal transduction resulting in expression of SEAP. SEAP activity is measured following addition of luminescence-based alkaline phosphatase substrate provided in the kit.
Brand:CaymanSKU:600180 - 100 testsAvailable on backorder
Immunogen: Synthetic peptide from the N-terminal region of mouse protein MC4R • Host: Rabbit • Species Reactivity: (+) Human, mouse, and rat • Applications: IHC (formalin-fixed paraffin-embedded sections) and WB
Brand:CaymanSKU:10006355- 1 eaAvailable on backorder
Immunogen: Synthetic peptide from the N-terminal region of mouse protein MC4R • Host: Rabbit • Species Reactivity: (+) Human, mouse, and rat • Applications: IHC (formalin-fixed paraffin-embedded sections) and WB
Brand:CaymanSKU:10006355- 1 ea Melanocortins are known to exert a broad array of physiological actions including ‘melanogenesis, steroidogenesis, sexual function and inflammation, as well as appetite regulation and energy homeostasis’.{12351} These actions are mediated (differentially or concurrently) in part by a family of G protein-coupled receptors, the melanocortin receptors 1-5 (MC1R-MC5R). Melanocortin-4 receptor (MC4R) was first cloned in 1993 with transcripts expressed primarily in the brain.{13229} Genetic studies of mice and humans have established a critical role of MC4R in appetite regulation.{3777} Heterozygous mutations in MC4R account for 1-6% of severe cases of human obesity. Thus, MC4R has been a prime target for therapeutic intervention in obesity.{10617} All known mammalian MC4Rs are 332 amino acids in length with an estimated molecular weight of 37 kDa. The protein is heavily glycosylated and appears at multiple positions on SDS-PAGE.{13230} Cayman’s MC4R Polyclonal Antibody mainly detects an unglycosylated protein at 37 kDa and a glycosylated protein at 55 kDa.
Brand:CaymanSKU:10006355 - 1 eaAvailable on backorder
The melanocortin-4 receptor (MC4R) has important roles in weight regulation, sexual function, and inflammation. Mice deficient in MC4R have increased lipid deposition associated with elevated adiposity, while mutations in MC4R in humans are associated with early onset or severe obesity. This assay consists of a 96-well plate coated with a transfection complex containing DNA constructs for MC4R and a cAMP response element regulated Secreted Alkaline Phosphatase (SEAP) reporter (MC4R Reverse Transfection Strip Plate). Cells grown on the transfection complex will express MC4R at the cell surface. Binding of agonists to MC4R initiates a signal transduction cascade resulting in expression of SEAP which is secreted into the cell culture media. SEAP activity is measured following addition of a luminescence-based alkaline phosphatase substrate provided in the kit.
Brand:CaymanSKU:600190 - 100 testsAvailable on backorder
Melatonin is an indoleamine neurohormone whose levels vary in a daily cycle, thereby allowing the entrainment of the circadian rhythms of several biological functions in animals, plants, and microbes.{22956} Many biological effects of melatonin are transduced through melatonin receptors, including the MT1, MT2, and MT3 subtypes.{22956} Melatonin also acts as a powerful antioxidant that protects lipids, proteins, and DNA against oxidative damage.{12743,4781} Glutathione peroxidase, superoxide dismutases, and catalase are upregulated by melatonin, and melatonin scavenges free radicals as a terminal antioxidant.{12743,4781}
Brand:CaymanSKU:- Melatonin is an indoleamine neurohormone whose levels vary in a daily cycle, thereby allowing the entrainment of the circadian rhythms of several biological functions in animals, plants, and microbes.{22956} Many biological effects of melatonin are transduced through melatonin receptors, including the MT1, MT2, and MT3 subtypes.{22956} Melatonin also acts as a powerful antioxidant that protects lipids, proteins, and DNA against oxidative damage.{12743,4781} Glutathione peroxidase, superoxide dismutases, and catalase are upregulated by melatonin, and melatonin scavenges free radicals as a terminal antioxidant.{12743,4781}
Brand:CaymanSKU:- Melatonin is an indoleamine neurohormone whose levels vary in a daily cycle, thereby allowing the entrainment of the circadian rhythms of several biological functions in animals, plants, and microbes.{22956} Many biological effects of melatonin are transduced through melatonin receptors, including the MT1, MT2, and MT3 subtypes.{22956} Melatonin also acts as a powerful antioxidant that protects lipids, proteins, and DNA against oxidative damage.{12743,4781} Glutathione peroxidase, superoxide dismutases, and catalase are upregulated by melatonin, and melatonin scavenges free radicals as a terminal antioxidant.{12743,4781}
Brand:CaymanSKU:- Melatonin is an indoleamine neurohormone whose levels vary in a daily cycle, thereby allowing the entrainment of the circadian rhythms of several biological functions in animals, plants, and microbes.{22956} Many biological effects of melatonin are transduced through melatonin receptors, including the MT1, MT2, and MT3 subtypes.{22956} Melatonin also acts as a powerful antioxidant that protects lipids, proteins, and DNA against oxidative damage.{12743,4781} Glutathione peroxidase, superoxide dismutases, and catalase are upregulated by melatonin, and melatonin scavenges free radicals as a terminal antioxidant.{12743,4781}
Brand:CaymanSKU:-
Melatonin-d4 is intended for use as an internal standard for the quantification of melatonin (Item No. 14427) by GC- or LC-MS. Melatonin is an indoleamine neurohormone whose levels vary in a daily cycle, thereby allowing the entrainment of the circadian rhythms of several biological functions in animals, plants, and microbes.{22956} Many biological effects of melatonin are transduced through melatonin receptors, including the MT1, MT2, and MT3 subtypes.{22956} Melatonin also acts as a powerful antioxidant that protects lipids, proteins, and DNA against oxidative damage.{12743,4781} Glutathione peroxidase, superoxide dismutases, and catalase are upregulated by melatonin, and melatonin scavenges free radicals as a terminal antioxidant.{12743,4781}
Brand:CaymanSKU:22291 -Out of stock
Melatonin-d4 is intended for use as an internal standard for the quantification of melatonin (Item No. 14427) by GC- or LC-MS. Melatonin is an indoleamine neurohormone whose levels vary in a daily cycle, thereby allowing the entrainment of the circadian rhythms of several biological functions in animals, plants, and microbes.{22956} Many biological effects of melatonin are transduced through melatonin receptors, including the MT1, MT2, and MT3 subtypes.{22956} Melatonin also acts as a powerful antioxidant that protects lipids, proteins, and DNA against oxidative damage.{12743,4781} Glutathione peroxidase, superoxide dismutases, and catalase are upregulated by melatonin, and melatonin scavenges free radicals as a terminal antioxidant.{12743,4781}
Brand:CaymanSKU:22291 -Out of stock
Melatonin-d4 is intended for use as an internal standard for the quantification of melatonin (Item No. 14427) by GC- or LC-MS. Melatonin is an indoleamine neurohormone whose levels vary in a daily cycle, thereby allowing the entrainment of the circadian rhythms of several biological functions in animals, plants, and microbes.{22956} Many biological effects of melatonin are transduced through melatonin receptors, including the MT1, MT2, and MT3 subtypes.{22956} Melatonin also acts as a powerful antioxidant that protects lipids, proteins, and DNA against oxidative damage.{12743,4781} Glutathione peroxidase, superoxide dismutases, and catalase are upregulated by melatonin, and melatonin scavenges free radicals as a terminal antioxidant.{12743,4781}
Brand:CaymanSKU:22291 -Out of stock
Meleagrin is an antibiotic derived from a deep ocean, penicillin-producing P. chrysogenum.{28881} It is produced as an end product in the roquefortine branched biosynthetic pathway.{28882,28883} Meleagrin has been identified as an inhibitor of the bacterial enoyl-acyl carrier protein reductase (FabI) with IC50 values of 40.1 and 33.2 µM for S. aureus and E. coli FabI, respectively.{28881} It inhibits the growth of S. aureus, E. coli, and S. pneumoniae with MICs ranging from 32-64 µg/ml.{28881}
Brand:CaymanSKU:-Available on backorder
Meleagrin is an antibiotic derived from a deep ocean, penicillin-producing P. chrysogenum.{28881} It is produced as an end product in the roquefortine branched biosynthetic pathway.{28882,28883} Meleagrin has been identified as an inhibitor of the bacterial enoyl-acyl carrier protein reductase (FabI) with IC50 values of 40.1 and 33.2 µM for S. aureus and E. coli FabI, respectively.{28881} It inhibits the growth of S. aureus, E. coli, and S. pneumoniae with MICs ranging from 32-64 µg/ml.{28881}
Brand:CaymanSKU:-Available on backorder
Melittin is a small protein that is the principal cytotoxic component of venom of the honey bee, A. mellifera.{29574} Structurally, melittin consists of two α-helical segments forming a bent rod, with hydrophilic residues on the convex side and hydrophobic sites on the concave side.{29574,29572} This allows melittin molecules to assemble as tetramers on membrane surfaces and form pores, resulting in cell death. Bee venom is also known to stimulate phospholipase A2 (PLA2) activity, and this may be linked to melittin-mediated pore production as well as the presence of low molecular weight PLA2 enzymes in the venom.{29572,29573} Melittin also has antimicrobial properties, which, combined with its cytolytic properties, extends its potential for therapeutic applications.{29573}
Brand:CaymanSKU:-Available on backorder
Melittin is a small protein that is the principal cytotoxic component of venom of the honey bee, A. mellifera.{29574} Structurally, melittin consists of two α-helical segments forming a bent rod, with hydrophilic residues on the convex side and hydrophobic sites on the concave side.{29574,29572} This allows melittin molecules to assemble as tetramers on membrane surfaces and form pores, resulting in cell death. Bee venom is also known to stimulate phospholipase A2 (PLA2) activity, and this may be linked to melittin-mediated pore production as well as the presence of low molecular weight PLA2 enzymes in the venom.{29572,29573} Melittin also has antimicrobial properties, which, combined with its cytolytic properties, extends its potential for therapeutic applications.{29573}
Brand:CaymanSKU:-Available on backorder
Melittin is a small protein that is the principal cytotoxic component of venom of the honey bee, A. mellifera.{29574} Structurally, melittin consists of two α-helical segments forming a bent rod, with hydrophilic residues on the convex side and hydrophobic sites on the concave side.{29574,29572} This allows melittin molecules to assemble as tetramers on membrane surfaces and form pores, resulting in cell death. Bee venom is also known to stimulate phospholipase A2 (PLA2) activity, and this may be linked to melittin-mediated pore production as well as the presence of low molecular weight PLA2 enzymes in the venom.{29572,29573} Melittin also has antimicrobial properties, which, combined with its cytolytic properties, extends its potential for therapeutic applications.{29573}
Brand:CaymanSKU:-Available on backorder