Cayman
Showing 28501–28650 of 45550 results
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Malotilate is a hepatoprotective agent.{46922} It inhibits A23187-induced metabolism of arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) to the 5-lipoxygenase (5-LO) metabolites leukotriene B4 (LTB4; Item No. 20110) and 5-HETE in macrophages isolated from the ascitic fluid of patients with alcoholic liver cirrhosis. Malotilate (50 mg/kg) prevents increases in plasma glutamic-pyruvic transaminase (GPT) and glutamic-oxaloacetic transaminase (GOT) activities in a rat model of carbon tetrachloride-induced liver injury.{46923} It reduces hepatic deposition of type III procollagen, type IV collagen, laminin, and fibronectin in a rat model of dimethylnitrosamine-induced hepatic fibrosis when administered at a dose of 100 mg/kg.{46924}
Brand:CaymanSKU:30266 - 1 gAvailable on backorder
Malotilate is a hepatoprotective agent.{46922} It inhibits A23187-induced metabolism of arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) to the 5-lipoxygenase (5-LO) metabolites leukotriene B4 (LTB4; Item No. 20110) and 5-HETE in macrophages isolated from the ascitic fluid of patients with alcoholic liver cirrhosis. Malotilate (50 mg/kg) prevents increases in plasma glutamic-pyruvic transaminase (GPT) and glutamic-oxaloacetic transaminase (GOT) activities in a rat model of carbon tetrachloride-induced liver injury.{46923} It reduces hepatic deposition of type III procollagen, type IV collagen, laminin, and fibronectin in a rat model of dimethylnitrosamine-induced hepatic fibrosis when administered at a dose of 100 mg/kg.{46924}
Brand:CaymanSKU:30266 - 5 gAvailable on backorder
Maltoheptaose is a maltooligosaccharide consisting of seven glucose units. It has been used as a substrate to study α-amylase transglycosylaion activity.{32387}
Brand:CaymanSKU:20758 -Available on backorder
Maltoheptaose is a maltooligosaccharide consisting of seven glucose units. It has been used as a substrate to study α-amylase transglycosylaion activity.{32387}
Brand:CaymanSKU:20758 -Available on backorder
Maltoheptaose is a maltooligosaccharide consisting of seven glucose units. It has been used as a substrate to study α-amylase transglycosylaion activity.{32387}
Brand:CaymanSKU:20758 -Available on backorder
Maltoheptaose is a maltooligosaccharide consisting of seven glucose units. It has been used as a substrate to study α-amylase transglycosylaion activity.{32387}
Brand:CaymanSKU:20758 -Available on backorder
Maltononaose is an oligosaccharide comprised of nine α-1,4-linked glucose molecules.{53542,53543} It has been used as a substrate to study the cleavage distribution and enzyme kinetics of B. licheniformis thermostable α-amylase, as well as the enzyme kinetics of A. niger glucoamylase II.{53542,53544}
Brand:CaymanSKU:29918 - 1 mgAvailable on backorder
Maltononaose is an oligosaccharide comprised of nine α-1,4-linked glucose molecules.{53542,53543} It has been used as a substrate to study the cleavage distribution and enzyme kinetics of B. licheniformis thermostable α-amylase, as well as the enzyme kinetics of A. niger glucoamylase II.{53542,53544}
Brand:CaymanSKU:29918 - 5 mgAvailable on backorder
Maltononaose is an oligosaccharide comprised of nine α-1,4-linked glucose molecules.{53542,53543} It has been used as a substrate to study the cleavage distribution and enzyme kinetics of B. licheniformis thermostable α-amylase, as well as the enzyme kinetics of A. niger glucoamylase II.{53542,53544}
Brand:CaymanSKU:29918 - 500 µgAvailable on backorder
Maltopentaose is an oligosaccharide comprised of five α-1,4-linked glucose molecules.{39838} It increases the α-amylase synthesis rate in B. stearothermophilus when used at a concentration of 1 mM. Maltopentaose has been used as a substrate for porcine pancreatic α-amylase (PPA) to study various inhibitors of PPA.{47627}
Brand:CaymanSKU:28456 - 10 mgAvailable on backorder
Maltopentaose is an oligosaccharide comprised of five α-1,4-linked glucose molecules.{39838} It increases the α-amylase synthesis rate in B. stearothermophilus when used at a concentration of 1 mM. Maltopentaose has been used as a substrate for porcine pancreatic α-amylase (PPA) to study various inhibitors of PPA.{47627}
Brand:CaymanSKU:28456 - 25 mgAvailable on backorder
Maltopentaose is an oligosaccharide comprised of five α-1,4-linked glucose molecules.{39838} It increases the α-amylase synthesis rate in B. stearothermophilus when used at a concentration of 1 mM. Maltopentaose has been used as a substrate for porcine pancreatic α-amylase (PPA) to study various inhibitors of PPA.{47627}
Brand:CaymanSKU:28456 - 5 mgAvailable on backorder
Maltopentaose is an oligosaccharide comprised of five α-1,4-linked glucose molecules.{39838} It increases the α-amylase synthesis rate in B. stearothermophilus when used at a concentration of 1 mM. Maltopentaose has been used as a substrate for porcine pancreatic α-amylase (PPA) to study various inhibitors of PPA.{47627}
Brand:CaymanSKU:28456 - 50 mgAvailable on backorder
Maltotetraose is a tetrasaccharide that is composed of glucose molecules linked by α-1,4 glycosidic bonds and has been found in B. stearothermophilus.{39837,39838,39839,39840} It increases the α-amylase synthesis rate in B. stearothermophilus 3-fold greater than sucrose or glucose (Item No. 23733) when used at a concentration of 0.1 mM.{39838} Maltotetraose (750 μg/ml) inhibits the growth of E. carotovora in a cylinder-agar plate assay but does not affect the growth of several other microorganisms.{39840} It also inhibits TNF-α-induced expression of intercellular adhesion molecule-1 (ICAM-1) in MOVAS-1 mouse smooth muscle cells (VSMCs) transfected with an ICAM-1 luciferase reporter when used at a concentration of 20 μM.{39841}
Brand:CaymanSKU:24975 - 10 mgAvailable on backorder
Maltotetraose is a tetrasaccharide that is composed of glucose molecules linked by α-1,4 glycosidic bonds and has been found in B. stearothermophilus.{39837,39838,39839,39840} It increases the α-amylase synthesis rate in B. stearothermophilus 3-fold greater than sucrose or glucose (Item No. 23733) when used at a concentration of 0.1 mM.{39838} Maltotetraose (750 μg/ml) inhibits the growth of E. carotovora in a cylinder-agar plate assay but does not affect the growth of several other microorganisms.{39840} It also inhibits TNF-α-induced expression of intercellular adhesion molecule-1 (ICAM-1) in MOVAS-1 mouse smooth muscle cells (VSMCs) transfected with an ICAM-1 luciferase reporter when used at a concentration of 20 μM.{39841}
Brand:CaymanSKU:24975 - 100 mgAvailable on backorder
Maltotetraose is a tetrasaccharide that is composed of glucose molecules linked by α-1,4 glycosidic bonds and has been found in B. stearothermophilus.{39837,39838,39839,39840} It increases the α-amylase synthesis rate in B. stearothermophilus 3-fold greater than sucrose or glucose (Item No. 23733) when used at a concentration of 0.1 mM.{39838} Maltotetraose (750 μg/ml) inhibits the growth of E. carotovora in a cylinder-agar plate assay but does not affect the growth of several other microorganisms.{39840} It also inhibits TNF-α-induced expression of intercellular adhesion molecule-1 (ICAM-1) in MOVAS-1 mouse smooth muscle cells (VSMCs) transfected with an ICAM-1 luciferase reporter when used at a concentration of 20 μM.{39841}
Brand:CaymanSKU:24975 - 5 mgAvailable on backorder
Maltotetraose is a tetrasaccharide that is composed of glucose molecules linked by α-1,4 glycosidic bonds and has been found in B. stearothermophilus.{39837,39838,39839,39840} It increases the α-amylase synthesis rate in B. stearothermophilus 3-fold greater than sucrose or glucose (Item No. 23733) when used at a concentration of 0.1 mM.{39838} Maltotetraose (750 μg/ml) inhibits the growth of E. carotovora in a cylinder-agar plate assay but does not affect the growth of several other microorganisms.{39840} It also inhibits TNF-α-induced expression of intercellular adhesion molecule-1 (ICAM-1) in MOVAS-1 mouse smooth muscle cells (VSMCs) transfected with an ICAM-1 luciferase reporter when used at a concentration of 20 μM.{39841}
Brand:CaymanSKU:24975 - 50 mgAvailable on backorder
Maltotriose is a trisaccharide consisting of three glucose molecules linked with α-1,4 glycosidic bonds. It serves as an inducer of the maltose regulon of E. coli.{32248}
Brand:CaymanSKU:20306 -Available on backorder
Maltotriose is a trisaccharide consisting of three glucose molecules linked with α-1,4 glycosidic bonds. It serves as an inducer of the maltose regulon of E. coli.{32248}
Brand:CaymanSKU:20306 -Available on backorder
Maltotriose is a trisaccharide consisting of three glucose molecules linked with α-1,4 glycosidic bonds. It serves as an inducer of the maltose regulon of E. coli.{32248}
Brand:CaymanSKU:20306 -Available on backorder
Malvidin is an O-methylated anthocyanidin responsible for the pigments in grapes and blueberries. It demonstrates antioxidant capacity with free radical scavenging properties in vitro.{31838,26210} It also exhibits antihypertensive activity by inhibiting angiotensin I-converting enzyme, anti-inflammatory effects by blocking the NF-κB pathway, antiproliferative properties by inhibiting various tumor cell lines, and counteracts oxidative stress in neuronal cells.{31838,20649,26207}
Brand:CaymanSKU:19752 -Available on backorder
Malvidin is an O-methylated anthocyanidin responsible for the pigments in grapes and blueberries. It demonstrates antioxidant capacity with free radical scavenging properties in vitro.{31838,26210} It also exhibits antihypertensive activity by inhibiting angiotensin I-converting enzyme, anti-inflammatory effects by blocking the NF-κB pathway, antiproliferative properties by inhibiting various tumor cell lines, and counteracts oxidative stress in neuronal cells.{31838,20649,26207}
Brand:CaymanSKU:19752 -Available on backorder
Malvidin is an O-methylated anthocyanidin responsible for the pigments in grapes and blueberries. It demonstrates antioxidant capacity with free radical scavenging properties in vitro.{31838,26210} It also exhibits antihypertensive activity by inhibiting angiotensin I-converting enzyme, anti-inflammatory effects by blocking the NF-κB pathway, antiproliferative properties by inhibiting various tumor cell lines, and counteracts oxidative stress in neuronal cells.{31838,20649,26207}
Brand:CaymanSKU:19752 -Available on backorder
MAM2201 (Item No. 9001219) is a synthetic cannabinoid (CB) that is closely related, structurally, to AM2201 (Item No. 10707), a compound which displays high affinities for both CB receptors. MAM2201 N-(4-hydroxypentyl) metabolite is a potential phase 1 metabolite of MAM2201, based on the known metabolism of similar compounds. The physiological properties of this compound have not been evaluated. This product is intended for forensic and research applications.
Brand:CaymanSKU:11778 - 1 mgAvailable on backorder
MAM2201 (Item No. 9001219) is a synthetic cannabinoid (CB) that is closely related, structurally, to AM2201 (Item No. 10707), a compound which displays high affinities for both CB receptors. MAM2201 N-(4-hydroxypentyl) metabolite is a potential phase 1 metabolite of MAM2201, based on the known metabolism of similar compounds. The physiological properties of this compound have not been evaluated. This product is intended for forensic and research applications.
Brand:CaymanSKU:11778 - 100 µgAvailable on backorder
MAM2201 (Item No. 9001219) is a synthetic cannabinoid (CB) that is closely related, structurally, to AM2201 (Item No. 10707), a compound which displays high affinities for both CB receptors. MAM2201 N-(4-hydroxypentyl) metabolite is a potential phase 1 metabolite of MAM2201, based on the known metabolism of similar compounds. The physiological properties of this compound have not been evaluated. This product is intended for forensic and research applications.
Brand:CaymanSKU:11778 - 500 µgAvailable on backorder
MAM2201 (Item No. 9001219) is a synthetic cannabinoid (CB) that is closely related, structurally, to AM2201 (Item No. 10707), a compound which displays high affinities for both CB receptors.{18696} MAM2201 N-(5-chloropentyl) analog differs from MAM2201 by having chlorine rather than fluorine on the terminal carbon of the alkyl group. The physiological properties of this compound have not been evaluated. This product is intended for forensic and research applications.
Brand:CaymanSKU:- MAM2201 (Item No. 9001219) is a synthetic cannabinoid (CB) that is closely related, structurally, to AM2201 (Item No. 10707), a compound which displays high affinities for both CB receptors.{18696} MAM2201 N-(5-chloropentyl) analog differs from MAM2201 by having chlorine rather than fluorine on the terminal carbon of the alkyl group. The physiological properties of this compound have not been evaluated. This product is intended for forensic and research applications.
Brand:CaymanSKU:- MAM2201 (Item No. 9001219) is a synthetic cannabinoid (CB) that is closely related, structurally, to AM2201 (Item No. 10707), a compound which displays high affinities for both CB receptors.{18696} MAM2201 N-(5-chloropentyl) analog differs from MAM2201 by having chlorine rather than fluorine on the terminal carbon of the alkyl group. The physiological properties of this compound have not been evaluated. This product is intended for forensic and research applications.
Brand:CaymanSKU:-
MAM2201 (Item No. 9001219) is a synthetic cannabinoid (CB) that is closely related, structurally, to AM2201 (Item No. 10707) and JWH 122 (Item No. 10591), two compounds which display high affinities for both CB receptors. MAM2201 N-pentanoic acid metabolite is a potential phase 1 metabolite of MAM2201 or JWH 122, based on the known metabolism of similar compounds. The physiological and toxicological properties of this compound have not been evaluated. This product is intended for forensic and research applications.
Brand:CaymanSKU:11779 - 1 mgAvailable on backorder
MAM2201 (Item No. 9001219) is a synthetic cannabinoid (CB) that is closely related, structurally, to AM2201 (Item No. 10707) and JWH 122 (Item No. 10591), two compounds which display high affinities for both CB receptors. MAM2201 N-pentanoic acid metabolite is a potential phase 1 metabolite of MAM2201 or JWH 122, based on the known metabolism of similar compounds. The physiological and toxicological properties of this compound have not been evaluated. This product is intended for forensic and research applications.
Brand:CaymanSKU:11779 - 10 mgAvailable on backorder
MAM2201 (Item No. 9001219) is a synthetic cannabinoid (CB) that is closely related, structurally, to AM2201 (Item No. 10707) and JWH 122 (Item No. 10591), two compounds which display high affinities for both CB receptors. MAM2201 N-pentanoic acid metabolite is a potential phase 1 metabolite of MAM2201 or JWH 122, based on the known metabolism of similar compounds. The physiological and toxicological properties of this compound have not been evaluated. This product is intended for forensic and research applications.
Brand:CaymanSKU:11779 - 5 mgAvailable on backorder
Mangiferin is a xanthone glucoside that has been found in M. indica with diverse biological activities.{37665} It increases survival of HIV-1-infected MT-2 human leukemia cells (EC50 = 3.59 μg/ml).{37662} In an ascitic fibrosarcoma (AFS) mouse xenograft model, mangiferin (10 μg/g) inhibits tumor growth by 47% at 15 days post inoculation and increases lifespan by 38% relative to control. Mangiferin (50 mg/kg, p.o.) reduces the production of hydrogen peroxide induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in mouse peritoneal macrophages by 40% ex vivo.{37663} It also decreases TPA-induced DNA fragmentation in mouse liver and brain by 35 and 22%, respectively. Mangiferin (0.25-2 mg/kg, i.p.) dose-dependently increases survival of γ-irradiated mice.{37664} Mangiferin (10 mg/kg, i.p.) reduces fasting plasma glucose, total cholesterol, triglycerides, and LDL cholesterol (LDL-C) levels in a rat model of diabetes induced by streptozotocin (Item No. 13104) by 50, 57, 38.5, and 70%, respectively.{37665}
Brand:CaymanSKU:22360 -Out of stock
Mangiferin is a xanthone glucoside that has been found in M. indica with diverse biological activities.{37665} It increases survival of HIV-1-infected MT-2 human leukemia cells (EC50 = 3.59 μg/ml).{37662} In an ascitic fibrosarcoma (AFS) mouse xenograft model, mangiferin (10 μg/g) inhibits tumor growth by 47% at 15 days post inoculation and increases lifespan by 38% relative to control. Mangiferin (50 mg/kg, p.o.) reduces the production of hydrogen peroxide induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in mouse peritoneal macrophages by 40% ex vivo.{37663} It also decreases TPA-induced DNA fragmentation in mouse liver and brain by 35 and 22%, respectively. Mangiferin (0.25-2 mg/kg, i.p.) dose-dependently increases survival of γ-irradiated mice.{37664} Mangiferin (10 mg/kg, i.p.) reduces fasting plasma glucose, total cholesterol, triglycerides, and LDL cholesterol (LDL-C) levels in a rat model of diabetes induced by streptozotocin (Item No. 13104) by 50, 57, 38.5, and 70%, respectively.{37665}
Brand:CaymanSKU:22360 -Out of stock
Manidipine is a dihydropyridine L- and T-type calcium channel blocker.{39642,39643,39644} It blocks recombinant rabbit L-type (α1Cα2/δβ1a) and human T-type (α1H) calcium channels expressed in Xenopus oocytes and native L-type channels in dissociated guinea pig cardiac ventricular cells (IC50 = 2.6 nM). Manidipine inhibits intracellular calcium increases induced by endothelin-1 (ET-1; Item No. 24127) in A7r5 rat vascular smooth muscle cells (ED50 = 1 nM) and potassium-induced contraction of isolated dog femoral and portal veins (IC50s = 24 and 2.1 nM, respectively).{39645,39646} In vivo, it lowers blood pressure in spontaneously hypertensive rats (SHRs) when administered at a dose of 10 mg/kg and inhibits left ventricular hypertrophy in rats induced by isoproterenol (Item No. 15592) when administered at a dose of 3 mg/kg.{39647,39648} Formulations containing manidipine have been used in the treatment of hypertension.
Brand:CaymanSKU:23614 - 10 mgAvailable on backorder
Manidipine is a dihydropyridine L- and T-type calcium channel blocker.{39642,39643,39644} It blocks recombinant rabbit L-type (α1Cα2/δβ1a) and human T-type (α1H) calcium channels expressed in Xenopus oocytes and native L-type channels in dissociated guinea pig cardiac ventricular cells (IC50 = 2.6 nM). Manidipine inhibits intracellular calcium increases induced by endothelin-1 (ET-1; Item No. 24127) in A7r5 rat vascular smooth muscle cells (ED50 = 1 nM) and potassium-induced contraction of isolated dog femoral and portal veins (IC50s = 24 and 2.1 nM, respectively).{39645,39646} In vivo, it lowers blood pressure in spontaneously hypertensive rats (SHRs) when administered at a dose of 10 mg/kg and inhibits left ventricular hypertrophy in rats induced by isoproterenol (Item No. 15592) when administered at a dose of 3 mg/kg.{39647,39648} Formulations containing manidipine have been used in the treatment of hypertension.
Brand:CaymanSKU:23614 - 25 mgAvailable on backorder
Manidipine is a dihydropyridine L- and T-type calcium channel blocker.{39642,39643,39644} It blocks recombinant rabbit L-type (α1Cα2/δβ1a) and human T-type (α1H) calcium channels expressed in Xenopus oocytes and native L-type channels in dissociated guinea pig cardiac ventricular cells (IC50 = 2.6 nM). Manidipine inhibits intracellular calcium increases induced by endothelin-1 (ET-1; Item No. 24127) in A7r5 rat vascular smooth muscle cells (ED50 = 1 nM) and potassium-induced contraction of isolated dog femoral and portal veins (IC50s = 24 and 2.1 nM, respectively).{39645,39646} In vivo, it lowers blood pressure in spontaneously hypertensive rats (SHRs) when administered at a dose of 10 mg/kg and inhibits left ventricular hypertrophy in rats induced by isoproterenol (Item No. 15592) when administered at a dose of 3 mg/kg.{39647,39648} Formulations containing manidipine have been used in the treatment of hypertension.
Brand:CaymanSKU:23614 - 50 mgAvailable on backorder
Manidipine-d4 is intended for use as an internal standard for the quantification of manidipine (Item No. 23614) by GC- or LC-MS. Manidipine is a dihydropyridine L- and T-type calcium channel blocker.{39642,39643,39644} It inhibits recombinant rabbit L-type (α1Cα2/δβ1a) and human T-type (α1H) calcium channels expressed in Xenopus oocytes and native L-type channels in dissociated guinea pig cardiac ventricular cells (IC50 = 2.6 nM). Manidipine inhibits intracellular calcium increases induced by endothelin-1 (ET-1; Item No. 24127) in A7r5 rat vascular smooth muscle cells (ED50 = 1 nM) and potassium-induced contraction of isolated dog femoral and portal veins (IC50s = 24 and 2.1 nM, respectively).{39645,39646} In vivo, it lowers blood pressure in spontaneously hypertensive rats (SHRs) when administered at a dose of 10 mg/kg and inhibits left ventricular hypertrophy in rats induced by isoproterenol (Item No. 15592) when administered at a dose of 3 mg/kg.{39647,39648} Formulations containing manidipine have been used in the treatment of hypertension.
Brand:CaymanSKU:30768 - 1 mgAvailable on backorder
Manumycin A is an antibiotic that acts as a potent and selective farnesyltransferase (FTase) inhibitor with anti-tumor activity.{15668,15667} It inhibits rat brain FTase with a Ki value of 1.2 µM, thereby preventing Ras activation which requires farnesylation at the C-terminus for membrane attachment.{15668} It exhibits significant antitumor activity against Ki-ras-activated solid tumors in mice at a dose of 6.3 mg/kg.{15668} Manymycin A inhibits IκB kinase (IKK), independent of FTase inhibition, in an number of cells types with effective concentrations of 2-10 µM.{15666} In ApoE-deficient mice, Manumycin A treatment for 22 weeks at 5 mg/kg reduced aortic fatty streak lesion size to 43% of vehicle-treated animals, indicating FTase inhibition as a potential target for prevention or treatment of atherosclerosis.{15035}
Brand:CaymanSKU:10010497 - 1 mgAvailable on backorder
Manumycin A is an antibiotic that acts as a potent and selective farnesyltransferase (FTase) inhibitor with anti-tumor activity.{15668,15667} It inhibits rat brain FTase with a Ki value of 1.2 µM, thereby preventing Ras activation which requires farnesylation at the C-terminus for membrane attachment.{15668} It exhibits significant antitumor activity against Ki-ras-activated solid tumors in mice at a dose of 6.3 mg/kg.{15668} Manymycin A inhibits IκB kinase (IKK), independent of FTase inhibition, in an number of cells types with effective concentrations of 2-10 µM.{15666} In ApoE-deficient mice, Manumycin A treatment for 22 weeks at 5 mg/kg reduced aortic fatty streak lesion size to 43% of vehicle-treated animals, indicating FTase inhibition as a potential target for prevention or treatment of atherosclerosis.{15035}
Brand:CaymanSKU:10010497 - 5 mgAvailable on backorder
Manzamine A is a β-carboline alkaloid with diverse activities that has been found in marine sponges, including X. ashmorica.{42149} It is an inhibitor of glycogen synthase kinase 3β (GSK3β) and cyclin-dependent kinase 5 (CDK5; IC50s = 10.2 and 1.5 μM, respectively).{42150} It inhibits the growth of L5178y mouse lymphoma cells with an ED50 value of 1.8 μg/mL.{42149} In an agar diffusion assay, manzamine A inhibits the growth of B. subtilis and S. aureus, but not E. coli bacteria. It reduces the reverse transcriptase (RT) activity in supernatant from HIV-1-infected peripheral blood mononuclear cells (PBMCs; EC50 = 4.2 μM).{42151} In vivo, manzamine A (100 μmol/kg, i.p.) has antimalarial activity and reduces the amount of P. berghei in infected mice by over 90% relative to the control.{42152} Manzamine A (132 ppm) inhibits the growth of S. littoralis larva by 80% when added to the larval diet.{42149}
Brand:CaymanSKU:21444 -Out of stock
Manzamine A is a β-carboline alkaloid with diverse activities that has been found in marine sponges, including X. ashmorica.{42149} It is an inhibitor of glycogen synthase kinase 3β (GSK3β) and cyclin-dependent kinase 5 (CDK5; IC50s = 10.2 and 1.5 μM, respectively).{42150} It inhibits the growth of L5178y mouse lymphoma cells with an ED50 value of 1.8 μg/mL.{42149} In an agar diffusion assay, manzamine A inhibits the growth of B. subtilis and S. aureus, but not E. coli bacteria. It reduces the reverse transcriptase (RT) activity in supernatant from HIV-1-infected peripheral blood mononuclear cells (PBMCs; EC50 = 4.2 μM).{42151} In vivo, manzamine A (100 μmol/kg, i.p.) has antimalarial activity and reduces the amount of P. berghei in infected mice by over 90% relative to the control.{42152} Manzamine A (132 ppm) inhibits the growth of S. littoralis larva by 80% when added to the larval diet.{42149}
Brand:CaymanSKU:21444 -Out of stock
Immunogen: Purified bovine MAP2 • Host: Mouse • Species Reactivity: (+) Human, Bovine, Mouse, Rat • Applications: ICC, IHC, WB • MW = ~280 kDa
Brand:CaymanSKU:29280- 100 µl Microtubule-associated protein 2 (MAP2) belongs to the microtubule-associated protein (MAP) family of cytoskeletal filament proteins, which includes MAP1-5 and tau.{55112} MAP2 is composed of an N-terminal projection domain that interacts with PKA and a C-terminal domain that contains microtubule binding repeats containing a KXGS motif that is subject to phosphorylation.{55113} Five isoforms of MAP2 are generated through alternative splicing and are found in the cell body and dendrites of neurons, with some isoforms also found in astrocytes and oligodendrocytes of the CNS and in the testis.{55113,55112} MAP2 is expressed in mature neurons, with the MAP2a and MAP2c isoforms expressed in a developmental stage-dependent manner while the MAP2b isoform is expressed throughout development and adulthood.{55114,55112} MAP2 binds to and stabilizes microtubules and increases their rigidity, as well as interacts with F-actin during neurite initiation and with proteins involved in signal transduction.{55113} Phosphorylation of the KXGS motif by MAP/microtubule affinity-regulating kinase 1 (MARK1), MARK2, or PKA decreases the affinity of MAP2 for microtubules, and the detachment of MAP2 leads to microtubule destabilization and disassembly. Decreased levels of MAP2 protein have been found in postmortem brain tissue from patients with a Lewy body variant of Alzheimer’s disease.{55115} MAP2 has been found in cytoplasmic neuronal Lewy bodies colocalized with α-synuclein and ubiquitin in postmortem substantia nigra from patients with Parkinson’s disease.{55116} Cayman’s MAP2 (bovine) Monoclonal Antibody (Clone 4H5) can be used for immunocytochemistry (ICC), immunohistochemistry (IHC), and Western blot (WB) applications. The antibody recognizes MAP2 at approximately 280 kDa from human, bovine, mouse, and rat samples.
Brand:CaymanSKU:29280 - 100 µlAvailable on backorder
Immunogen: Purified bovine MAP2 • Host: Mouse • Species Reactivity: (+) Human, Bovine, Mouse, Rat • Applications: ICC, IHC, WB • MW = ~280 kDa
Brand:CaymanSKU:29280- 100 µlAvailable on backorder
Immunogen: Recombinant bovine MAP2 expressed in E. coli • Host: Chicken • Species Reactivity: (+) Human, Bovine, Mouse, Rat • Cross Reactivity: none provided • Applications: ICC, IHC, WB • MW = ~280 kDa
Brand:CaymanSKU:29281- 100 µl Microtubule-associated protein 2 (MAP2) belongs to the microtubule-associated protein (MAP) family of cytoskeletal filament proteins, which includes MAP1-5 and tau.{55112} MAP2 is composed of an N-terminal projection domain that interacts with PKA and a C-terminal domain that contains microtubule binding repeats containing a KXGS motif that is subject to phosphorylation.{55113} Five isoforms of MAP2 are generated through alternative splicing and are found in the cell body and dendrites of neurons, with some isoforms also found in astrocytes and oligodendrocytes of the CNS and in the testis.{55112,55113} MAP2 is expressed in mature neurons, with the MAP2a and MAP2c isoforms expressed in a developmental stage-dependent manner while the MAP2b isoform is expressed throughout development and adulthood.{55112,55114} MAP2 binds to and stabilizes microtubules and increases their rigidity, as well as interacts with F-actin during neurite initiation and with proteins involved in signal transduction.{55113} Phosphorylation of the KXGS motif by MAP/microtubule affinity-regulating kinase 1 (MARK1), MARK2, or PKA decreases the affinity of MAP2 for microtubules, and the detachment of MAP2 leads to microtubule destabilization and disassembly. Decreased levels of MAP2 protein have been found in postmortem brain tissue from patients with a Lewy body variant of Alzheimer’s disease.{55115} MAP2 has been found in cytoplasmic neuronal Lewy bodies colocalized with α-synuclein and ubiquitin in postmortem substantia nigra from patients with Parkinson’s disease.{55116} Cayman’s MAP2 (bovine) Polyclonal Antibody can be used for immunocytochemistry (ICC), immunohistochemistry (IHC), Western blot (WB) applications. The antibody recognizes MAP2 at approximately 280 kDa from human, bovine, mouse, and rat samples.
Brand:CaymanSKU:29281 - 100 µlAvailable on backorder
Immunogen: Recombinant bovine MAP2 expressed in E. coli • Host: Chicken • Species Reactivity: (+) Human, Bovine, Mouse, Rat • Cross Reactivity: none provided • Applications: ICC, IHC, WB • MW = ~280 kDa
Brand:CaymanSKU:29281- 100 µlAvailable on backorder
Immunogen: Recombinant human MAP2 expressed in E. coli • Host: Goat • Species Reactivity: (+) Human, Mouse, Rat • Applications: ICC, IHC, WB • MW = ~280 kDa
Brand:CaymanSKU:29282- 100 µl Microtubule-associated protein 2 (MAP2) belongs to the microtubule-associated protein (MAP) family of cytoskeletal filament proteins, which includes MAP1-5 and tau.{55112} MAP2 is composed of an N-terminal projection domain that interacts with PKA and a C-terminal domain that contains microtubule binding repeats containing a KXGS motif that is subject to phosphorylation.{55113} Five isoforms of MAP2 are generated through alternative splicing and are found in the cell body and dendrites of neurons, with some isoforms also found in astrocytes and oligodendrocytes of the CNS and in the testis.{55112,55113} MAP2 is expressed in mature neurons, with the MAP2a and MAP2c isoforms expressed in a developmental stage-dependent manner while the MAP2b isoform is expressed throughout development and adulthood.{55112,55114} MAP2 binds to and stabilizes microtubules and increases their rigidity, as well as interacts with F-actin during neurite initiation and with proteins involved in signal transduction.{55113} Phosphorylation of the KXGS motif by MAP/microtubule affinity-regulating kinase 1 (MARK1), MARK2, or PKA decreases the affinity of MAP2 for microtubules, and the detachment of MAP2 leads to microtubule destabilization and disassembly. Decreased levels of MAP2 protein have been found in postmortem brain tissue from patients with a Lewy body variant of Alzheimer’s disease.{55115} MAP2 has been found in cytoplasmic neuronal Lewy bodies colocalized with α-synuclein and ubiquitin in postmortem substantia nigra from patients with Parkinson’s disease.{55116} Cayman’s MAP2 (human) Monoclonal Antibody can be used for immunocytochemistry (ICC), immunohistochemistry (IHC), and Western blot (WB) applications. The antibody recognizes MAP2 at approximately 280 kDa from human, mouse, and rat samples.
Brand:CaymanSKU:29282 - 100 µlAvailable on backorder
Immunogen: Recombinant human MAP2 expressed in E. coli • Host: Goat • Species Reactivity: (+) Human, Mouse, Rat • Applications: ICC, IHC, WB • MW = ~280 kDa
Brand:CaymanSKU:29282- 100 µlAvailable on backorder
Maprotiline is a norepinephrine reuptake inhibitor that binds the norepinephrine transporter with a KD value of 11.1 nM.{22877} Comparatively, it only weakly associates with serotonin and dopamine transporters (KDs = 5.8 and 1 µM, respectively).{22877} However, maprotiline moderately inhibits serotonin 5-HT2A receptors with a Ki value of 51 nM.{25805} Maprotiline has also been reported to bind the histamine H1, muscarinic acetylcholine, α1-adrenergic, and dopamine D2 receptors with KD values of 2, 570, 90, and 350 nM, respectively.{25914} It has been used in the treatment of depression and also has been reported to possess sedative, anxiolytic, and sympathomimetic activities.{26037,25873}
Brand:CaymanSKU:- Maprotiline is a norepinephrine reuptake inhibitor that binds the norepinephrine transporter with a KD value of 11.1 nM.{22877} Comparatively, it only weakly associates with serotonin and dopamine transporters (KDs = 5.8 and 1 µM, respectively).{22877} However, maprotiline moderately inhibits serotonin 5-HT2A receptors with a Ki value of 51 nM.{25805} Maprotiline has also been reported to bind the histamine H1, muscarinic acetylcholine, α1-adrenergic, and dopamine D2 receptors with KD values of 2, 570, 90, and 350 nM, respectively.{25914} It has been used in the treatment of depression and also has been reported to possess sedative, anxiolytic, and sympathomimetic activities.{26037,25873}
Brand:CaymanSKU:- Maprotiline is a norepinephrine reuptake inhibitor that binds the norepinephrine transporter with a KD value of 11.1 nM.{22877} Comparatively, it only weakly associates with serotonin and dopamine transporters (KDs = 5.8 and 1 µM, respectively).{22877} However, maprotiline moderately inhibits serotonin 5-HT2A receptors with a Ki value of 51 nM.{25805} Maprotiline has also been reported to bind the histamine H1, muscarinic acetylcholine, α1-adrenergic, and dopamine D2 receptors with KD values of 2, 570, 90, and 350 nM, respectively.{25914} It has been used in the treatment of depression and also has been reported to possess sedative, anxiolytic, and sympathomimetic activities.{26037,25873}
Brand:CaymanSKU:-
Maraviroc is an antagonist of the chemokine (C-C motif) receptor 5 (CCR5; Ki = 0.24 nM for the rhesus monkey recombinant receptor).{45486} It inhibits binding of MIP-1α, MIP-1β, and RANTES to HEK293 cell membranes expressing CCR5 (IC50s = 3.3, 7.2, and 5.2 nM, respectively) and inhibits HIV-1 binding to CCR5 via glycoprotein 120 (gp120) and gp160 (IC50s = 11 and 0.22 nM, respectively).{45484} Maraviroc is selective for CCR5 over CCR1, -2, -3, -4, -7, and -8, and chemokine (C-X-C motif) receptor 1 (CXCR1) and CXCR2 in a panel of immunological assays for ligand-induced cell chemotaxis and ligand-receptor binding (IC50s = >10 µM for all). It has antiviral activity against laboratory and clinical isolates of CCR5-tropic (IC50s = 0.1-1.1 nM), but not CXCR4-tropic or dual tropic (IC50s = >10 µM), HIV-1 in isolated human peripheral blood mononuclear cells (PBMCs). Maraviroc prevents infection upon exposure to HIV-1 in humanized RAG-hum mice when administered at a dose of 62 mg/kg.{45485}
Brand:CaymanSKU:- Maraviroc is an antagonist of the chemokine (C-C motif) receptor 5 (CCR5; Ki = 0.24 nM for the rhesus monkey recombinant receptor).{45486} It inhibits binding of MIP-1α, MIP-1β, and RANTES to HEK293 cell membranes expressing CCR5 (IC50s = 3.3, 7.2, and 5.2 nM, respectively) and inhibits HIV-1 binding to CCR5 via glycoprotein 120 (gp120) and gp160 (IC50s = 11 and 0.22 nM, respectively).{45484} Maraviroc is selective for CCR5 over CCR1, -2, -3, -4, -7, and -8, and chemokine (C-X-C motif) receptor 1 (CXCR1) and CXCR2 in a panel of immunological assays for ligand-induced cell chemotaxis and ligand-receptor binding (IC50s = >10 µM for all). It has antiviral activity against laboratory and clinical isolates of CCR5-tropic (IC50s = 0.1-1.1 nM), but not CXCR4-tropic or dual tropic (IC50s = >10 µM), HIV-1 in isolated human peripheral blood mononuclear cells (PBMCs). Maraviroc prevents infection upon exposure to HIV-1 in humanized RAG-hum mice when administered at a dose of 62 mg/kg.{45485}
Brand:CaymanSKU:- Maraviroc is an antagonist of the chemokine (C-C motif) receptor 5 (CCR5; Ki = 0.24 nM for the rhesus monkey recombinant receptor).{45486} It inhibits binding of MIP-1α, MIP-1β, and RANTES to HEK293 cell membranes expressing CCR5 (IC50s = 3.3, 7.2, and 5.2 nM, respectively) and inhibits HIV-1 binding to CCR5 via glycoprotein 120 (gp120) and gp160 (IC50s = 11 and 0.22 nM, respectively).{45484} Maraviroc is selective for CCR5 over CCR1, -2, -3, -4, -7, and -8, and chemokine (C-X-C motif) receptor 1 (CXCR1) and CXCR2 in a panel of immunological assays for ligand-induced cell chemotaxis and ligand-receptor binding (IC50s = >10 µM for all). It has antiviral activity against laboratory and clinical isolates of CCR5-tropic (IC50s = 0.1-1.1 nM), but not CXCR4-tropic or dual tropic (IC50s = >10 µM), HIV-1 in isolated human peripheral blood mononuclear cells (PBMCs). Maraviroc prevents infection upon exposure to HIV-1 in humanized RAG-hum mice when administered at a dose of 62 mg/kg.{45485}
Brand:CaymanSKU:- Maraviroc is an antagonist of the chemokine (C-C motif) receptor 5 (CCR5; Ki = 0.24 nM for the rhesus monkey recombinant receptor).{45486} It inhibits binding of MIP-1α, MIP-1β, and RANTES to HEK293 cell membranes expressing CCR5 (IC50s = 3.3, 7.2, and 5.2 nM, respectively) and inhibits HIV-1 binding to CCR5 via glycoprotein 120 (gp120) and gp160 (IC50s = 11 and 0.22 nM, respectively).{45484} Maraviroc is selective for CCR5 over CCR1, -2, -3, -4, -7, and -8, and chemokine (C-X-C motif) receptor 1 (CXCR1) and CXCR2 in a panel of immunological assays for ligand-induced cell chemotaxis and ligand-receptor binding (IC50s = >10 µM for all). It has antiviral activity against laboratory and clinical isolates of CCR5-tropic (IC50s = 0.1-1.1 nM), but not CXCR4-tropic or dual tropic (IC50s = >10 µM), HIV-1 in isolated human peripheral blood mononuclear cells (PBMCs). Maraviroc prevents infection upon exposure to HIV-1 in humanized RAG-hum mice when administered at a dose of 62 mg/kg.{45485}
Brand:CaymanSKU:-
Marbofloxacin is a fluoroquinolone antibiotic that is active against P. multocida in vitro (MIC = 0.016 μg/ml).{39533} It exhibits broad-spectrum antibacterial activity mediated by the inhibition of DNA gyrase, with MIC values ranging from 0.016 to 0.4 and 0.19 to 1.7 µg/ml against various Gram-negative and Gram-positive bacterial isolates, respectively.{39536} In vivo, the administration of marbofloxacin (2 mg/kg, i.m.) after infection prevents the formation of pulmonary lesions in a bovine calf model of M. haemolytica A1 pneumonia.{39534} Oral marbofloxacin (2 mg/kg per day) also exhibits antileishmanial activity in a canine model of leishmaniasis, decreasing parasitic load by 72%.{39535} Formulations containing marbofloxacin have been used in the veterinary treatment of bacterial infections.
Brand:CaymanSKU:24174 - 1 gAvailable on backorder
Marbofloxacin is a fluoroquinolone antibiotic that is active against P. multocida in vitro (MIC = 0.016 μg/ml).{39533} It exhibits broad-spectrum antibacterial activity mediated by the inhibition of DNA gyrase, with MIC values ranging from 0.016 to 0.4 and 0.19 to 1.7 µg/ml against various Gram-negative and Gram-positive bacterial isolates, respectively.{39536} In vivo, the administration of marbofloxacin (2 mg/kg, i.m.) after infection prevents the formation of pulmonary lesions in a bovine calf model of M. haemolytica A1 pneumonia.{39534} Oral marbofloxacin (2 mg/kg per day) also exhibits antileishmanial activity in a canine model of leishmaniasis, decreasing parasitic load by 72%.{39535} Formulations containing marbofloxacin have been used in the veterinary treatment of bacterial infections.
Brand:CaymanSKU:24174 - 5 gAvailable on backorder
Marcfortine A is an indole alkaloid originally isolated from P. roqueforti.{39450} It has nematocidal activity against the parasitic nematode H. contortus (LD99 = 0.06 μg/ml) and inhibits motility of adult worms (EC50 = 2 μM).{39451},{39453} Marcfortine A eliminates H. contortus, T. colubriformis, and O. ostertagi from experimentally infected jirds (ED95s = 0.33, 0.11, and 2.5 mg/animal, respectively).{39453} It dose-dependently inhibits nicotine-induced calcium mobilization in SH-SY5Y and TE-671 cells expressing α3 subunit-containing human nicotinic acetylcholine receptors (nAChRs) and muscle-type nAChRs, respectively.{39452}
Brand:CaymanSKU:23486 - 1 mgAvailable on backorder
Marcfortine A is an indole alkaloid originally isolated from P. roqueforti.{39450} It has nematocidal activity against the parasitic nematode H. contortus (LD99 = 0.06 μg/ml) and inhibits motility of adult worms (EC50 = 2 μM).{39451},{39453} Marcfortine A eliminates H. contortus, T. colubriformis, and O. ostertagi from experimentally infected jirds (ED95s = 0.33, 0.11, and 2.5 mg/animal, respectively).{39453} It dose-dependently inhibits nicotine-induced calcium mobilization in SH-SY5Y and TE-671 cells expressing α3 subunit-containing human nicotinic acetylcholine receptors (nAChRs) and muscle-type nAChRs, respectively.{39452}
Brand:CaymanSKU:23486 - 5 mgAvailable on backorder
Docosahexaenoic acid (DHA; Item No. 90310) is an ω-3 fatty acid that is abundant in the brain and the retina and is known to be important in early development.{18389,18390} Maresin 1 (7(R)-MaR1) is a 7,14-dihydroxy DHA formed from 14(S)-hydroperoxy DHA supplied exogenously to resident peritoneal mouse macrophages activated with zymosan A. It potently reduces infiltration of neutrophils into the mouse peritoneum in zymosan A-induced peritonitis when given intravenously (0.2 ng) and significantly increases phagocytosis of FITC-labeled zymosan A by isolated mouse macrophages (0.1-100 nM).{16640} Analytical and biological comparisons of synthetic 7(R)-MaR1 with endogenously derived 7(R)-MaR1 have confirmed its identity as matching the natural product.{14569}
Brand:CaymanSKU:10878 - 10 µgAvailable on backorder
Docosahexaenoic acid (DHA; Item No. 90310) is an ω-3 fatty acid that is abundant in the brain and the retina and is known to be important in early development.{18389,18390} Maresin 1 (7(R)-MaR1) is a 7,14-dihydroxy DHA formed from 14(S)-hydroperoxy DHA supplied exogenously to resident peritoneal mouse macrophages activated with zymosan A. It potently reduces infiltration of neutrophils into the mouse peritoneum in zymosan A-induced peritonitis when given intravenously (0.2 ng) and significantly increases phagocytosis of FITC-labeled zymosan A by isolated mouse macrophages (0.1-100 nM).{16640} Analytical and biological comparisons of synthetic 7(R)-MaR1 with endogenously derived 7(R)-MaR1 have confirmed its identity as matching the natural product.{14569}
Brand:CaymanSKU:10878 - 100 µgAvailable on backorder
Docosahexaenoic acid (DHA; Item No. 90310) is an ω-3 fatty acid that is abundant in the brain and the retina and is known to be important in early development.{18389,18390} Maresin 1 (7(R)-MaR1) is a 7,14-dihydroxy DHA formed from 14(S)-hydroperoxy DHA supplied exogenously to resident peritoneal mouse macrophages activated with zymosan A. It potently reduces infiltration of neutrophils into the mouse peritoneum in zymosan A-induced peritonitis when given intravenously (0.2 ng) and significantly increases phagocytosis of FITC-labeled zymosan A by isolated mouse macrophages (0.1-100 nM).{16640} Analytical and biological comparisons of synthetic 7(R)-MaR1 with endogenously derived 7(R)-MaR1 have confirmed its identity as matching the natural product.{14569}
Brand:CaymanSKU:10878 - 25 µgAvailable on backorder
Docosahexaenoic acid (DHA; Item No. 90310) is an ω-3 fatty acid that is abundant in the brain and the retina and is known to be important in early development.{18389,18390} Maresin 1 (7(R)-MaR1) is a 7,14-dihydroxy DHA formed from 14(S)-hydroperoxy DHA supplied exogenously to resident peritoneal mouse macrophages activated with zymosan A. It potently reduces infiltration of neutrophils into the mouse peritoneum in zymosan A-induced peritonitis when given intravenously (0.2 ng) and significantly increases phagocytosis of FITC-labeled zymosan A by isolated mouse macrophages (0.1-100 nM).{16640} Analytical and biological comparisons of synthetic 7(R)-MaR1 with endogenously derived 7(R)-MaR1 have confirmed its identity as matching the natural product.{14569}
Brand:CaymanSKU:10878 - 50 µgAvailable on backorder
Maresins (macrophage mediators in resolving inflammation) are members of a class of potent anti-inflammatory and pro-resolving mediators that are synthesized by macrophages in the presence of docosahexaenoic acid (DHA). Maresin 1 (MaR1) is produced via oxidation of endogenous DHA by 12-lipoxygenase. MaR1 has been shown to reduce neutrophil infiltration in murine peritonitis, enhance efferocytosis, inhibit TRPV1 currents in neurons, reduce neuropathic pain in mice, and attenuate disease severity in mouse models of colitis. Although circulating levels of MaR1 may be quite low, MaR1 can be detected in urine.
Brand:CaymanSKU:501150 - 96 solid wellsAvailable on backorder
Maresins (macrophage mediators in resolving inflammation) are members of a class of potent anti-inflammatory and pro-resolving mediators that are synthesized by macrophages in the presence of docosahexaenoic acid (DHA). Maresin 1 (MaR1) is produced via oxidation of endogenous DHA by 12-lipoxygenase. MaR1 has been shown to reduce neutrophil infiltration in murine peritonitis, enhance efferocytosis, inhibit TRPV1 currents in neurons, reduce neuropathic pain in mice, and attenuate disease severity in mouse models of colitis. Although circulating levels of MaR1 may be quite low, MaR1 can be detected in urine.
Brand:CaymanSKU:501150 - 96 strip wellsAvailable on backorder
Docosahexaenoic acid (DHA; Item No. 90310) is an ω-3 fatty acid that is abundant in the brain and the retina and is known to be important in early development.{18389,18390} Maresin 2 (MaR2) is a 13R,14S-dihydroxy DHA formed by recombinant human macrophage 12-lipoxygenase and soluble epoxide hydrolase co-incubated with DHA.{26522} At 1 ng/mouse, MaR2 was shown to reduce neutrophil infiltration by 40% in a mouse model of peritonitis, and at 10 pM, MaR2 can enhance human macrophage phagocytosis of zymosan A by 90%.{26522} Analytical and biological comparisons of synthetic MaR2 with endogenously derived MaR2 have confirmed its identity as matching the natural product.{14569}
Brand:CaymanSKU:-Out of stock
Docosahexaenoic acid (DHA; Item No. 90310) is an ω-3 fatty acid that is abundant in the brain and the retina and is known to be important in early development.{18389,18390} Maresin 2 (MaR2) is a 13R,14S-dihydroxy DHA formed by recombinant human macrophage 12-lipoxygenase and soluble epoxide hydrolase co-incubated with DHA.{26522} At 1 ng/mouse, MaR2 was shown to reduce neutrophil infiltration by 40% in a mouse model of peritonitis, and at 10 pM, MaR2 can enhance human macrophage phagocytosis of zymosan A by 90%.{26522} Analytical and biological comparisons of synthetic MaR2 with endogenously derived MaR2 have confirmed its identity as matching the natural product.{14569}
Brand:CaymanSKU:-Out of stock
Docosahexaenoic acid (DHA; Item No. 90310) is an ω-3 fatty acid that is abundant in the brain and the retina and is known to be important in early development.{18389,18390} Maresin 2 (MaR2) is a 13R,14S-dihydroxy DHA formed by recombinant human macrophage 12-lipoxygenase and soluble epoxide hydrolase co-incubated with DHA.{26522} At 1 ng/mouse, MaR2 was shown to reduce neutrophil infiltration by 40% in a mouse model of peritonitis, and at 10 pM, MaR2 can enhance human macrophage phagocytosis of zymosan A by 90%.{26522} Analytical and biological comparisons of synthetic MaR2 with endogenously derived MaR2 have confirmed its identity as matching the natural product.{14569}
Brand:CaymanSKU:-Out of stock
Docosahexaenoic acid (DHA; Item No. 90310) is an ω-3 fatty acid that is abundant in the brain and the retina and is known to be important in early development.{18389,18390} Maresin 2 (MaR2) is a 13R,14S-dihydroxy DHA formed by recombinant human macrophage 12-lipoxygenase and soluble epoxide hydrolase co-incubated with DHA.{26522} At 1 ng/mouse, MaR2 was shown to reduce neutrophil infiltration by 40% in a mouse model of peritonitis, and at 10 pM, MaR2 can enhance human macrophage phagocytosis of zymosan A by 90%.{26522} Analytical and biological comparisons of synthetic MaR2 with endogenously derived MaR2 have confirmed its identity as matching the natural product.{14569}
Brand:CaymanSKU:-Out of stock
Marimastat is a broad-spectrum matrix metalloproteinase (MMP) inhibitor (IC50s = 5, 6, 230, 16, and 3 nM for MMP-1, MMP-2, MMP-3, MMP-7, and MMP-9, respectively).{38559} It also binds to a recombinantly expressed catalytic domain of human MMP-14 (MMP-14cat; Ki = 2.1 nM) and inhibits gelatinases (IC50s = 3–6 nM), fibroblast collagenase (IC50 = 5 nM), and matrylisin (IC50 = 16 nM).{38564} It inhibits peritoneal dissemination of implanted human gastric carcinoma TMK-1 cells in nude mice (18 mg/kg per day) but does not affect TMK-1 viability in vitro, providing only 2.64% inhibition when used at a concentration of 10 μM.{38560} Marimastat inhibits lymph node metastasis in an oral squamous cell carcinoma (OSCC) OSC-19 mouse xenograft model (30 mg/kg per day).{38561} It also delays tumor growth of human head and neck squamous cell SCC-1 xenografts in nude mice alone and when combined with chemoradiation when administered at a dose of 8.7 mg/kg per day.{38562} Marimastat is an inhibitor of tumor necrosis factor alpha (TNF-α) convertase (TACE), which catalyzes pro-TNF-α conversion into TNF-α (IC50s = 3.8 and 7,000 nM for purified TACE and whole blood, respectively).{38563}
Brand:CaymanSKU:- Marimastat is a broad-spectrum matrix metalloproteinase (MMP) inhibitor (IC50s = 5, 6, 230, 16, and 3 nM for MMP-1, MMP-2, MMP-3, MMP-7, and MMP-9, respectively).{38559} It also binds to a recombinantly expressed catalytic domain of human MMP-14 (MMP-14cat; Ki = 2.1 nM) and inhibits gelatinases (IC50s = 3–6 nM), fibroblast collagenase (IC50 = 5 nM), and matrylisin (IC50 = 16 nM).{38564} It inhibits peritoneal dissemination of implanted human gastric carcinoma TMK-1 cells in nude mice (18 mg/kg per day) but does not affect TMK-1 viability in vitro, providing only 2.64% inhibition when used at a concentration of 10 μM.{38560} Marimastat inhibits lymph node metastasis in an oral squamous cell carcinoma (OSCC) OSC-19 mouse xenograft model (30 mg/kg per day).{38561} It also delays tumor growth of human head and neck squamous cell SCC-1 xenografts in nude mice alone and when combined with chemoradiation when administered at a dose of 8.7 mg/kg per day.{38562} Marimastat is an inhibitor of tumor necrosis factor alpha (TNF-α) convertase (TACE), which catalyzes pro-TNF-α conversion into TNF-α (IC50s = 3.8 and 7,000 nM for purified TACE and whole blood, respectively).{38563}
Brand:CaymanSKU:- Marimastat is a broad-spectrum matrix metalloproteinase (MMP) inhibitor (IC50s = 5, 6, 230, 16, and 3 nM for MMP-1, MMP-2, MMP-3, MMP-7, and MMP-9, respectively).{38559} It also binds to a recombinantly expressed catalytic domain of human MMP-14 (MMP-14cat; Ki = 2.1 nM) and inhibits gelatinases (IC50s = 3–6 nM), fibroblast collagenase (IC50 = 5 nM), and matrylisin (IC50 = 16 nM).{38564} It inhibits peritoneal dissemination of implanted human gastric carcinoma TMK-1 cells in nude mice (18 mg/kg per day) but does not affect TMK-1 viability in vitro, providing only 2.64% inhibition when used at a concentration of 10 μM.{38560} Marimastat inhibits lymph node metastasis in an oral squamous cell carcinoma (OSCC) OSC-19 mouse xenograft model (30 mg/kg per day).{38561} It also delays tumor growth of human head and neck squamous cell SCC-1 xenografts in nude mice alone and when combined with chemoradiation when administered at a dose of 8.7 mg/kg per day.{38562} Marimastat is an inhibitor of tumor necrosis factor alpha (TNF-α) convertase (TACE), which catalyzes pro-TNF-α conversion into TNF-α (IC50s = 3.8 and 7,000 nM for purified TACE and whole blood, respectively).{38563}
Brand:CaymanSKU:- Marimastat is a broad-spectrum matrix metalloproteinase (MMP) inhibitor (IC50s = 5, 6, 230, 16, and 3 nM for MMP-1, MMP-2, MMP-3, MMP-7, and MMP-9, respectively).{38559} It also binds to a recombinantly expressed catalytic domain of human MMP-14 (MMP-14cat; Ki = 2.1 nM) and inhibits gelatinases (IC50s = 3–6 nM), fibroblast collagenase (IC50 = 5 nM), and matrylisin (IC50 = 16 nM).{38564} It inhibits peritoneal dissemination of implanted human gastric carcinoma TMK-1 cells in nude mice (18 mg/kg per day) but does not affect TMK-1 viability in vitro, providing only 2.64% inhibition when used at a concentration of 10 μM.{38560} Marimastat inhibits lymph node metastasis in an oral squamous cell carcinoma (OSCC) OSC-19 mouse xenograft model (30 mg/kg per day).{38561} It also delays tumor growth of human head and neck squamous cell SCC-1 xenografts in nude mice alone and when combined with chemoradiation when administered at a dose of 8.7 mg/kg per day.{38562} Marimastat is an inhibitor of tumor necrosis factor alpha (TNF-α) convertase (TACE), which catalyzes pro-TNF-α conversion into TNF-α (IC50s = 3.8 and 7,000 nM for purified TACE and whole blood, respectively).{38563}
Brand:CaymanSKU:-
Marinobufagenin (MBG) is a bufadienolide steroid first isolated from toads of genus Bufo. It can also be excreted by mammalian cells, particularly kidney cells from hypertensive animals.{32977} MBG inhibits the ouabain-resistant α1 Na+/K+ ATPase subunit (IC50 = 78 nM), impairing a major sodium pump of the kidneys, resulting in natriuresis and arterial hypertension.{32977,32979} Serum and urine levels of MBG are also elevated after cardiac infarction, and a reduced form of MBG, marinobufotoxin, occurs in the plasma of patients with terminal renal failure.{32978,32979} Through its effects on the α1 Na+/K+ ATPase subunit, MBG has profound immediate and prolonged effects on kidney, heart, and vascular functions.{32979}
Brand:CaymanSKU:20798 -Available on backorder
Marinobufagenin (MBG) is a bufadienolide steroid first isolated from toads of genus Bufo. It can also be excreted by mammalian cells, particularly kidney cells from hypertensive animals.{32977} MBG inhibits the ouabain-resistant α1 Na+/K+ ATPase subunit (IC50 = 78 nM), impairing a major sodium pump of the kidneys, resulting in natriuresis and arterial hypertension.{32977,32979} Serum and urine levels of MBG are also elevated after cardiac infarction, and a reduced form of MBG, marinobufotoxin, occurs in the plasma of patients with terminal renal failure.{32978,32979} Through its effects on the α1 Na+/K+ ATPase subunit, MBG has profound immediate and prolonged effects on kidney, heart, and vascular functions.{32979}
Brand:CaymanSKU:20798 -Available on backorder
Marinobufagenin (MBG) is a bufadienolide steroid first isolated from toads of genus Bufo. It can also be excreted by mammalian cells, particularly kidney cells from hypertensive animals.{32977} MBG inhibits the ouabain-resistant α1 Na+/K+ ATPase subunit (IC50 = 78 nM), impairing a major sodium pump of the kidneys, resulting in natriuresis and arterial hypertension.{32977,32979} Serum and urine levels of MBG are also elevated after cardiac infarction, and a reduced form of MBG, marinobufotoxin, occurs in the plasma of patients with terminal renal failure.{32978,32979} Through its effects on the α1 Na+/K+ ATPase subunit, MBG has profound immediate and prolonged effects on kidney, heart, and vascular functions.{32979}
Brand:CaymanSKU:20798 -Available on backorder
Marmesin is a coumarin originally isolated from the mature bark of A. marmelos.{36707} Marmesin decreases proliferation and cell invasion induced by fetal bovine serum (FBS) in H1299 non-small cell lung cancer cells (NSCLCs) when used at a concentration of 10 µM.{36708} It decreases VEGF secretion in A549 and H1299 cells and inhibits capillary-like structure formation by human umbilical vein endothelial cells (HUVECs). Marmesin also decreases proliferation of U937 human leukemia cells (IC50 = 40 µM).{36709} It halts the cell cycle at the G2/M phase, increases the ratio of Bax to Bcl-2 protein, induces apoptosis, and inhibits cell migration. Marmesin reduces tumor growth in a U937 mouse xenograft model when administered at a dose of 30 mg/kg.
Brand:CaymanSKU:25049 - 10 mgAvailable on backorder
Marmesin is a coumarin originally isolated from the mature bark of A. marmelos.{36707} Marmesin decreases proliferation and cell invasion induced by fetal bovine serum (FBS) in H1299 non-small cell lung cancer cells (NSCLCs) when used at a concentration of 10 µM.{36708} It decreases VEGF secretion in A549 and H1299 cells and inhibits capillary-like structure formation by human umbilical vein endothelial cells (HUVECs). Marmesin also decreases proliferation of U937 human leukemia cells (IC50 = 40 µM).{36709} It halts the cell cycle at the G2/M phase, increases the ratio of Bax to Bcl-2 protein, induces apoptosis, and inhibits cell migration. Marmesin reduces tumor growth in a U937 mouse xenograft model when administered at a dose of 30 mg/kg.
Brand:CaymanSKU:25049 - 25 mgAvailable on backorder