Cayman
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![A partial agonist of GPR109A/HCA2 receptors (Ki = 0.55 μM in a radioligand binding assay); stimulates [35S]-GTPγS binding and increases phosphorylation of ERK in HEK293T cells expressing GPR109A/HCA2 receptors (EC50s = 3.1 and 0.32 μM](https://interpriseusa.com/wp-content/uploads/2021/06/15423.png)
LUF6283 is a partial agonist of GPR109A/HCA2 G protein-coupled receptors (Ki = 0.55 μM in a radioligand binding assay).{42585} It stimulates [35S]-GTPγS binding and increases phosphorylation of ERK in HEK293T cells expressing GPR109A/HCA2 receptors (EC50s = 3.1 and 0.32 μM, respectively). In vivo, LUF6283 (400 mg/kg per day) reduces plasma levels of VLDL and hepatic expression of apolipoprotein B in mice.
Brand:CaymanSKU:- LUF6283 is a partial agonist of GPR109A/HCA2 G protein-coupled receptors (Ki = 0.55 μM in a radioligand binding assay).{42585} It stimulates [35S]-GTPγS binding and increases phosphorylation of ERK in HEK293T cells expressing GPR109A/HCA2 receptors (EC50s = 3.1 and 0.32 μM, respectively). In vivo, LUF6283 (400 mg/kg per day) reduces plasma levels of VLDL and hepatic expression of apolipoprotein B in mice.
Brand:CaymanSKU:- LUF6283 is a partial agonist of GPR109A/HCA2 G protein-coupled receptors (Ki = 0.55 μM in a radioligand binding assay).{42585} It stimulates [35S]-GTPγS binding and increases phosphorylation of ERK in HEK293T cells expressing GPR109A/HCA2 receptors (EC50s = 3.1 and 0.32 μM, respectively). In vivo, LUF6283 (400 mg/kg per day) reduces plasma levels of VLDL and hepatic expression of apolipoprotein B in mice.
Brand:CaymanSKU:- LUF6283 is a partial agonist of GPR109A/HCA2 G protein-coupled receptors (Ki = 0.55 μM in a radioligand binding assay).{42585} It stimulates [35S]-GTPγS binding and increases phosphorylation of ERK in HEK293T cells expressing GPR109A/HCA2 receptors (EC50s = 3.1 and 0.32 μM, respectively). In vivo, LUF6283 (400 mg/kg per day) reduces plasma levels of VLDL and hepatic expression of apolipoprotein B in mice.
Brand:CaymanSKU:-
Luffariellolide is a natural sesterterpenoid which reversibly inhibits secretory phospholipase A2 isoforms from bee venom (IC50 = 230 nM) and snake venom, reducing inflammation.{23775} It blocks the production of platelet-activating factor in stimulated neutrophils (IC50 = 5 μM).{23770} Luffariellolide is also a structural mimic of all-trans retinoic acid (RA) and, at 1 μM, acts as an agonist for the RA receptors RAR α, β, and γ but not for other nuclear receptors.{23773} In RA-sensitive cancer cell lines, luffariellolide induces the expression of RAR target genes and inhibits cell growth.{23773} It also inhibits the activation of hypoxia-inducible factor by hypoxia (IC50 = 3.6 μM).{23774}
Brand:CaymanSKU:-
Luliconazole is a broad spectrum imidazole that is active against various fungi, including Tinea, Candida, Trichophyton, Aspergillus, and Epidermophyton.{40272,40274} It has MIC values of 2.5-20, 0.63-2.5, 31-250, and ≤0.31-0.63 ng/ml for T. mentagrophytes, T. rubrum, C. albicans, and A. fumigatus, respectively, in broth dilution assays. In vitro, luliconazole has a geometric mean MIC value of 2.35 ng/ml against A. terreus, a fungal species responsible for life-threatening invasive aspergillosis in immunocompromised and high-risk patients.{40273} It prevents mortality in rats with systemic A. fumigatus infections and in mice with systemic C. albicans infections.{40274} It is effective in eliminating tinea pedis in a guinea pig model when used topically at a concentration of 1% once per day for seven days.{40272} Topical formulations containing luliconazole have been used in the treatment of fungal infections.
Brand:CaymanSKU:23120 - 1 gAvailable on backorder
Luliconazole is a broad spectrum imidazole that is active against various fungi, including Tinea, Candida, Trichophyton, Aspergillus, and Epidermophyton.{40272,40274} It has MIC values of 2.5-20, 0.63-2.5, 31-250, and ≤0.31-0.63 ng/ml for T. mentagrophytes, T. rubrum, C. albicans, and A. fumigatus, respectively, in broth dilution assays. In vitro, luliconazole has a geometric mean MIC value of 2.35 ng/ml against A. terreus, a fungal species responsible for life-threatening invasive aspergillosis in immunocompromised and high-risk patients.{40273} It prevents mortality in rats with systemic A. fumigatus infections and in mice with systemic C. albicans infections.{40274} It is effective in eliminating tinea pedis in a guinea pig model when used topically at a concentration of 1% once per day for seven days.{40272} Topical formulations containing luliconazole have been used in the treatment of fungal infections.
Brand:CaymanSKU:23120 - 250 mgAvailable on backorder
Luliconazole is a broad spectrum imidazole that is active against various fungi, including Tinea, Candida, Trichophyton, Aspergillus, and Epidermophyton.{40272,40274} It has MIC values of 2.5-20, 0.63-2.5, 31-250, and ≤0.31-0.63 ng/ml for T. mentagrophytes, T. rubrum, C. albicans, and A. fumigatus, respectively, in broth dilution assays. In vitro, luliconazole has a geometric mean MIC value of 2.35 ng/ml against A. terreus, a fungal species responsible for life-threatening invasive aspergillosis in immunocompromised and high-risk patients.{40273} It prevents mortality in rats with systemic A. fumigatus infections and in mice with systemic C. albicans infections.{40274} It is effective in eliminating tinea pedis in a guinea pig model when used topically at a concentration of 1% once per day for seven days.{40272} Topical formulations containing luliconazole have been used in the treatment of fungal infections.
Brand:CaymanSKU:23120 - 5 gAvailable on backorder
Luliconazole is a broad spectrum imidazole that is active against various fungi, including Tinea, Candida, Trichophyton, Aspergillus, and Epidermophyton.{40272,40274} It has MIC values of 2.5-20, 0.63-2.5, 31-250, and ≤0.31-0.63 ng/ml for T. mentagrophytes, T. rubrum, C. albicans, and A. fumigatus, respectively, in broth dilution assays. In vitro, luliconazole has a geometric mean MIC value of 2.35 ng/ml against A. terreus, a fungal species responsible for life-threatening invasive aspergillosis in immunocompromised and high-risk patients.{40273} It prevents mortality in rats with systemic A. fumigatus infections and in mice with systemic C. albicans infections.{40274} It is effective in eliminating tinea pedis in a guinea pig model when used topically at a concentration of 1% once per day for seven days.{40272} Topical formulations containing luliconazole have been used in the treatment of fungal infections.
Brand:CaymanSKU:23120 - 500 mgAvailable on backorder
Lumefantrine is an antimalarial drug that is used in combination with artemether (Item No. 11815).{26532} The pairing of lumefantrine and artemether is a major form of oral artemisinin combination therapy used against uncomplicated P. falciparum malaria.{28281,21234} Lumefantrine also blocks the rapidly activating delayed-rectifier potassium channel (IKr; IC50 = 8.1 µM).{24505}
Brand:CaymanSKU:20678 -Available on backorder
Lumefantrine is an antimalarial drug that is used in combination with artemether (Item No. 11815).{26532} The pairing of lumefantrine and artemether is a major form of oral artemisinin combination therapy used against uncomplicated P. falciparum malaria.{28281,21234} Lumefantrine also blocks the rapidly activating delayed-rectifier potassium channel (IKr; IC50 = 8.1 µM).{24505}
Brand:CaymanSKU:20678 -Available on backorder
Lumefantrine is an antimalarial drug that is used in combination with artemether (Item No. 11815).{26532} The pairing of lumefantrine and artemether is a major form of oral artemisinin combination therapy used against uncomplicated P. falciparum malaria.{28281,21234} Lumefantrine also blocks the rapidly activating delayed-rectifier potassium channel (IKr; IC50 = 8.1 µM).{24505}
Brand:CaymanSKU:20678 -Available on backorder
Lumefantrine is an antimalarial drug that is used in combination with artemether (Item No. 11815).{26532} The pairing of lumefantrine and artemether is a major form of oral artemisinin combination therapy used against uncomplicated P. falciparum malaria.{28281,21234} Lumefantrine also blocks the rapidly activating delayed-rectifier potassium channel (IKr; IC50 = 8.1 µM).{24505}
Brand:CaymanSKU:20678 -Available on backorder
Lumichrome is a natural metabolite of riboflavin. It can be made by photolysis of riboflavin or it can be produced enzymatically in certain microbes and plants.{34351,34353,34358} Lumichrome produced by Rhizobium and other bacterial species induces major developmental changes in plants at nanomolar concentrations.{34353,34355} Lumichrome can stimulate larval metamorphosis in ascidians and activate the LasR quorum sensing receptor of bacteria.{34356,34357} Lumichrome competitively inhibits the uptake of riboflavin by riboflavin transporters from prokaryotes and eukaryotes.{34352,32833}
Brand:CaymanSKU:20730 -Available on backorder
Lumichrome is a natural metabolite of riboflavin. It can be made by photolysis of riboflavin or it can be produced enzymatically in certain microbes and plants.{34351,34353,34358} Lumichrome produced by Rhizobium and other bacterial species induces major developmental changes in plants at nanomolar concentrations.{34353,34355} Lumichrome can stimulate larval metamorphosis in ascidians and activate the LasR quorum sensing receptor of bacteria.{34356,34357} Lumichrome competitively inhibits the uptake of riboflavin by riboflavin transporters from prokaryotes and eukaryotes.{34352,32833}
Brand:CaymanSKU:20730 -Available on backorder
Lumichrome is a natural metabolite of riboflavin. It can be made by photolysis of riboflavin or it can be produced enzymatically in certain microbes and plants.{34351,34353,34358} Lumichrome produced by Rhizobium and other bacterial species induces major developmental changes in plants at nanomolar concentrations.{34353,34355} Lumichrome can stimulate larval metamorphosis in ascidians and activate the LasR quorum sensing receptor of bacteria.{34356,34357} Lumichrome competitively inhibits the uptake of riboflavin by riboflavin transporters from prokaryotes and eukaryotes.{34352,32833}
Brand:CaymanSKU:20730 -Available on backorder
Lumichrome is a natural metabolite of riboflavin. It can be made by photolysis of riboflavin or it can be produced enzymatically in certain microbes and plants.{34351,34353,34358} Lumichrome produced by Rhizobium and other bacterial species induces major developmental changes in plants at nanomolar concentrations.{34353,34355} Lumichrome can stimulate larval metamorphosis in ascidians and activate the LasR quorum sensing receptor of bacteria.{34356,34357} Lumichrome competitively inhibits the uptake of riboflavin by riboflavin transporters from prokaryotes and eukaryotes.{34352,32833}
Brand:CaymanSKU:20730 -Available on backorder
Lumiflavine is a structural analog of the water-soluble vitamin riboflavin that has been used to study the mechanism of uptake of riboflavin into intestinal epithelial (Caco-2) and human retinal pigment epithelial (hRPE) cells.{32832,32833} It inhibits the uptake of radiolabeled riboflavin approximately 3-fold (at 25 µM) and 30-fold (at 10 µM) in Caco-2 cells and hRPE cells, respectively.{32832,32833}
Brand:CaymanSKU:20645 -Available on backorder
Lumiflavine is a structural analog of the water-soluble vitamin riboflavin that has been used to study the mechanism of uptake of riboflavin into intestinal epithelial (Caco-2) and human retinal pigment epithelial (hRPE) cells.{32832,32833} It inhibits the uptake of radiolabeled riboflavin approximately 3-fold (at 25 µM) and 30-fold (at 10 µM) in Caco-2 cells and hRPE cells, respectively.{32832,32833}
Brand:CaymanSKU:20645 -Available on backorder
Lumiflavine is a structural analog of the water-soluble vitamin riboflavin that has been used to study the mechanism of uptake of riboflavin into intestinal epithelial (Caco-2) and human retinal pigment epithelial (hRPE) cells.{32832,32833} It inhibits the uptake of radiolabeled riboflavin approximately 3-fold (at 25 µM) and 30-fold (at 10 µM) in Caco-2 cells and hRPE cells, respectively.{32832,32833}
Brand:CaymanSKU:20645 -Available on backorder
Lumiflavine is a structural analog of the water-soluble vitamin riboflavin that has been used to study the mechanism of uptake of riboflavin into intestinal epithelial (Caco-2) and human retinal pigment epithelial (hRPE) cells.{32832,32833} It inhibits the uptake of radiolabeled riboflavin approximately 3-fold (at 25 µM) and 30-fold (at 10 µM) in Caco-2 cells and hRPE cells, respectively.{32832,32833}
Brand:CaymanSKU:20645 -Available on backorder
Luminol is a cyclic diacyl hydrazide that exhibits chemiluminescence upon oxidation. For example, HRP, combined with hydrogen peroxide as an activator, causes luminescent peroxidation of luminol.{27587} This reaction can be enhanced by certain phenol derivatives, such as p-substituted phenols.{27586} Luminol can also be oxidized, and chemiluminesce, by compounds containing iron, copper, gold, and cyanide.{27585,24232} The excitation/emission maxima for luminol are 355/411 nm.
Brand:CaymanSKU:-Out of stock
Luminol is a cyclic diacyl hydrazide that exhibits chemiluminescence upon oxidation. For example, HRP, combined with hydrogen peroxide as an activator, causes luminescent peroxidation of luminol.{27587} This reaction can be enhanced by certain phenol derivatives, such as p-substituted phenols.{27586} Luminol can also be oxidized, and chemiluminesce, by compounds containing iron, copper, gold, and cyanide.{27585,24232} The excitation/emission maxima for luminol are 355/411 nm.
Brand:CaymanSKU:-Out of stock
Luminol is a cyclic diacyl hydrazide that exhibits chemiluminescence upon oxidation. For example, HRP, combined with hydrogen peroxide as an activator, causes luminescent peroxidation of luminol.{27587} This reaction can be enhanced by certain phenol derivatives, such as p-substituted phenols.{27586} Luminol can also be oxidized, and chemiluminesce, by compounds containing iron, copper, gold, and cyanide.{27585,24232} The excitation/emission maxima for luminol are 355/411 nm.
Brand:CaymanSKU:-Out of stock
Luminol is a cyclic diacyl hydrazide that exhibits chemiluminescence upon oxidation. For example, HRP, combined with hydrogen peroxide as an activator, causes luminescent peroxidation of luminol.{27587} This reaction can be enhanced by certain phenol derivatives, such as p-substituted phenols.{27586} Luminol can also be oxidized, and chemiluminesce, by compounds containing iron, copper, gold, and cyanide.{27585,24232} The excitation/emission maxima for luminol are 355/411 nm.
Brand:CaymanSKU:-Out of stock
Lumiracoxib is a selective inhibitor of COX-2 with IC50 values of 0.13 and 67 µM for COX-2 and COX-1, respectively, in isolated human whole blood.{45516} It reduces increases in the levels of prostaglandin E2 (PGE2; Item No. 14010) induced by IL-1β in human dermal fibroblasts (IC50 = 0.14 µM), as well as in LPS-stimulated RAW 264.7 cells when used at concentrations ranging from 1 to 100 µM.{45516},{45517} Lumiracoxib (3 and 10 mg/kg) also decreases LPS-induced increases in the levels of PGE2 in a rat model of air pouch inflammation.{45518} It reduces M. tuberculosis-induced increases in hind paw volume and the radiological and histopathological severity of arthritic lesions in a rat model of chronic arthritis when administered at a dose of 2 mg/kg.{45516}
Brand:CaymanSKU:27645 - 10 mgAvailable on backorder
Lumiracoxib is a selective inhibitor of COX-2 with IC50 values of 0.13 and 67 µM for COX-2 and COX-1, respectively, in isolated human whole blood.{45516} It reduces increases in the levels of prostaglandin E2 (PGE2; Item No. 14010) induced by IL-1β in human dermal fibroblasts (IC50 = 0.14 µM), as well as in LPS-stimulated RAW 264.7 cells when used at concentrations ranging from 1 to 100 µM.{45516},{45517} Lumiracoxib (3 and 10 mg/kg) also decreases LPS-induced increases in the levels of PGE2 in a rat model of air pouch inflammation.{45518} It reduces M. tuberculosis-induced increases in hind paw volume and the radiological and histopathological severity of arthritic lesions in a rat model of chronic arthritis when administered at a dose of 2 mg/kg.{45516}
Brand:CaymanSKU:27645 - 100 mgAvailable on backorder
Lumiracoxib is a selective inhibitor of COX-2 with IC50 values of 0.13 and 67 µM for COX-2 and COX-1, respectively, in isolated human whole blood.{45516} It reduces increases in the levels of prostaglandin E2 (PGE2; Item No. 14010) induced by IL-1β in human dermal fibroblasts (IC50 = 0.14 µM), as well as in LPS-stimulated RAW 264.7 cells when used at concentrations ranging from 1 to 100 µM.{45516},{45517} Lumiracoxib (3 and 10 mg/kg) also decreases LPS-induced increases in the levels of PGE2 in a rat model of air pouch inflammation.{45518} It reduces M. tuberculosis-induced increases in hind paw volume and the radiological and histopathological severity of arthritic lesions in a rat model of chronic arthritis when administered at a dose of 2 mg/kg.{45516}
Brand:CaymanSKU:27645 - 50 mgAvailable on backorder
Luotonin A is an alkaloid originally isolated from a plant used in traditional Chinese medicine.{22184} It inhibits the growth of mouse leukemia P388 cells (IC50 = 1.8 μg/ml).{22184} Luotonin A is structurally similar to the alkaloid camptothecin (Item No. 11694) and, like camptothecin, it binds to and stabilizes the topoisomerase I-DNA binary complex, leading to DNA breakage and cell death (IC50 = 5.07-12.6 μM).{25352} Also like camptothecin, luotonin A forms non-covalent complexes with double-stranded DNA in the minor groove and this association can be followed by native fluorescence associated with the aromatic and heterocyclic ring structure.{25350} Luotonin A also selectively inhibits the cytochrome P450 (CYP) isoforms CYP1A1 and CYP1A2 (IC50 = ~6 μM for each) in human liver microsomes.{25351}
Brand:CaymanSKU:- Luotonin A is an alkaloid originally isolated from a plant used in traditional Chinese medicine.{22184} It inhibits the growth of mouse leukemia P388 cells (IC50 = 1.8 μg/ml).{22184} Luotonin A is structurally similar to the alkaloid camptothecin (Item No. 11694) and, like camptothecin, it binds to and stabilizes the topoisomerase I-DNA binary complex, leading to DNA breakage and cell death (IC50 = 5.07-12.6 μM).{25352} Also like camptothecin, luotonin A forms non-covalent complexes with double-stranded DNA in the minor groove and this association can be followed by native fluorescence associated with the aromatic and heterocyclic ring structure.{25350} Luotonin A also selectively inhibits the cytochrome P450 (CYP) isoforms CYP1A1 and CYP1A2 (IC50 = ~6 μM for each) in human liver microsomes.{25351}
Brand:CaymanSKU:- Luotonin A is an alkaloid originally isolated from a plant used in traditional Chinese medicine.{22184} It inhibits the growth of mouse leukemia P388 cells (IC50 = 1.8 μg/ml).{22184} Luotonin A is structurally similar to the alkaloid camptothecin (Item No. 11694) and, like camptothecin, it binds to and stabilizes the topoisomerase I-DNA binary complex, leading to DNA breakage and cell death (IC50 = 5.07-12.6 μM).{25352} Also like camptothecin, luotonin A forms non-covalent complexes with double-stranded DNA in the minor groove and this association can be followed by native fluorescence associated with the aromatic and heterocyclic ring structure.{25350} Luotonin A also selectively inhibits the cytochrome P450 (CYP) isoforms CYP1A1 and CYP1A2 (IC50 = ~6 μM for each) in human liver microsomes.{25351}
Brand:CaymanSKU:- Luotonin A is an alkaloid originally isolated from a plant used in traditional Chinese medicine.{22184} It inhibits the growth of mouse leukemia P388 cells (IC50 = 1.8 μg/ml).{22184} Luotonin A is structurally similar to the alkaloid camptothecin (Item No. 11694) and, like camptothecin, it binds to and stabilizes the topoisomerase I-DNA binary complex, leading to DNA breakage and cell death (IC50 = 5.07-12.6 μM).{25352} Also like camptothecin, luotonin A forms non-covalent complexes with double-stranded DNA in the minor groove and this association can be followed by native fluorescence associated with the aromatic and heterocyclic ring structure.{25350} Luotonin A also selectively inhibits the cytochrome P450 (CYP) isoforms CYP1A1 and CYP1A2 (IC50 = ~6 μM for each) in human liver microsomes.{25351}
Brand:CaymanSKU:- Luotonin A is an alkaloid originally isolated from a plant used in traditional Chinese medicine.{22184} It inhibits the growth of mouse leukemia P388 cells (IC50 = 1.8 μg/ml).{22184} Luotonin A is structurally similar to the alkaloid camptothecin (Item No. 11694) and, like camptothecin, it binds to and stabilizes the topoisomerase I-DNA binary complex, leading to DNA breakage and cell death (IC50 = 5.07-12.6 μM).{25352} Also like camptothecin, luotonin A forms non-covalent complexes with double-stranded DNA in the minor groove and this association can be followed by native fluorescence associated with the aromatic and heterocyclic ring structure.{25350} Luotonin A also selectively inhibits the cytochrome P450 (CYP) isoforms CYP1A1 and CYP1A2 (IC50 = ~6 μM for each) in human liver microsomes.{25351}
Brand:CaymanSKU:-
Luotonin F is an alkaloid found in the aerial parts of the P. nigellastrum Bunge, a plant used in traditional Chinese medicine for the treatment of rheumatism and various other inflammatory conditions.{22184} It demonstrates cytotoxicity against leukemia P-388 cells (IC50 = 2.3 µM) through a mechanism that involves stabilizing the DNA topoisomerase I-DNA complex.{22184,25352,25350}
Brand:CaymanSKU:- Luotonin F is an alkaloid found in the aerial parts of the P. nigellastrum Bunge, a plant used in traditional Chinese medicine for the treatment of rheumatism and various other inflammatory conditions.{22184} It demonstrates cytotoxicity against leukemia P-388 cells (IC50 = 2.3 µM) through a mechanism that involves stabilizing the DNA topoisomerase I-DNA complex.{22184,25352,25350}
Brand:CaymanSKU:- Luotonin F is an alkaloid found in the aerial parts of the P. nigellastrum Bunge, a plant used in traditional Chinese medicine for the treatment of rheumatism and various other inflammatory conditions.{22184} It demonstrates cytotoxicity against leukemia P-388 cells (IC50 = 2.3 µM) through a mechanism that involves stabilizing the DNA topoisomerase I-DNA complex.{22184,25352,25350}
Brand:CaymanSKU:- Luotonin F is an alkaloid found in the aerial parts of the P. nigellastrum Bunge, a plant used in traditional Chinese medicine for the treatment of rheumatism and various other inflammatory conditions.{22184} It demonstrates cytotoxicity against leukemia P-388 cells (IC50 = 2.3 µM) through a mechanism that involves stabilizing the DNA topoisomerase I-DNA complex.{22184,25352,25350}
Brand:CaymanSKU:- Luotonin F is an alkaloid found in the aerial parts of the P. nigellastrum Bunge, a plant used in traditional Chinese medicine for the treatment of rheumatism and various other inflammatory conditions.{22184} It demonstrates cytotoxicity against leukemia P-388 cells (IC50 = 2.3 µM) through a mechanism that involves stabilizing the DNA topoisomerase I-DNA complex.{22184,25352,25350}
Brand:CaymanSKU:- Luotonin F is an alkaloid found in the aerial parts of the P. nigellastrum Bunge, a plant used in traditional Chinese medicine for the treatment of rheumatism and various other inflammatory conditions.{22184} It demonstrates cytotoxicity against leukemia P-388 cells (IC50 = 2.3 µM) through a mechanism that involves stabilizing the DNA topoisomerase I-DNA complex.{22184,25352,25350}
Brand:CaymanSKU:- Luotonin F is an alkaloid found in the aerial parts of the P. nigellastrum Bunge, a plant used in traditional Chinese medicine for the treatment of rheumatism and various other inflammatory conditions.{22184} It demonstrates cytotoxicity against leukemia P-388 cells (IC50 = 2.3 µM) through a mechanism that involves stabilizing the DNA topoisomerase I-DNA complex.{22184,25352,25350}
Brand:CaymanSKU:-
Lupeol, a dietary triterpene found in certain fruits, vegetables, and medicinal plants, has potent anti-inflammatory, anticarcinogenic, antimutagenic, and antimalarial activity. It suppresses the growth of hepatocellular carcinoma cell lines SMMC7721 and HepG2 with IC50 values of 45 and 48.5 μM and melanoma cell lines Mel 928 and Mel 1241 with IC50 values of 75 and 72 μM.{20463,20465} At 0.76 g/kg lupeol causes a significant decrease in the blood pressure of stroke-prone hypertensive rats and reduces expression of hepatic genes involved in triglyceride and cholesterol synthesis.{20464} It also has significant anti-inflammatory effects at 50 mg/kg in a carrageenan-induced edema model, inhibiting neutrophil migration.{20466}
Brand:CaymanSKU:11215 - 10 mgAvailable on backorder
Lupeol, a dietary triterpene found in certain fruits, vegetables, and medicinal plants, has potent anti-inflammatory, anticarcinogenic, antimutagenic, and antimalarial activity. It suppresses the growth of hepatocellular carcinoma cell lines SMMC7721 and HepG2 with IC50 values of 45 and 48.5 μM and melanoma cell lines Mel 928 and Mel 1241 with IC50 values of 75 and 72 μM.{20463,20465} At 0.76 g/kg lupeol causes a significant decrease in the blood pressure of stroke-prone hypertensive rats and reduces expression of hepatic genes involved in triglyceride and cholesterol synthesis.{20464} It also has significant anti-inflammatory effects at 50 mg/kg in a carrageenan-induced edema model, inhibiting neutrophil migration.{20466}
Brand:CaymanSKU:11215 - 25 mgAvailable on backorder
Lupeol, a dietary triterpene found in certain fruits, vegetables, and medicinal plants, has potent anti-inflammatory, anticarcinogenic, antimutagenic, and antimalarial activity. It suppresses the growth of hepatocellular carcinoma cell lines SMMC7721 and HepG2 with IC50 values of 45 and 48.5 μM and melanoma cell lines Mel 928 and Mel 1241 with IC50 values of 75 and 72 μM.{20463,20465} At 0.76 g/kg lupeol causes a significant decrease in the blood pressure of stroke-prone hypertensive rats and reduces expression of hepatic genes involved in triglyceride and cholesterol synthesis.{20464} It also has significant anti-inflammatory effects at 50 mg/kg in a carrageenan-induced edema model, inhibiting neutrophil migration.{20466}
Brand:CaymanSKU:11215 - 5 mgAvailable on backorder
Lupulone is a beta-acid that has been found in the hop plant, H. lupulus, and has diverse biological activities, including antibacterial, antioxidant, and anticarcinogenic properties.{45412,45413,45416} Lupulone is active against B. subtilis and S. aureus (MICs = 1 and 1.2 µg/ml, respectively), as well as T. b. brucei and L. m. mexicana (IC50s = 0.9 and 4.7 µg/ml, respectively).{45412,45413} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in a cell-free assay and inhibits lipid peroxidation in rat brain homogenates (IC50s = 25 and 39 µM, respectively).{45414} It reduces proliferation, migration, and capillary tube formation in human umbilical vein endothelial cells (HUVECs) when used at concentrations ranging from 2.5 to 50 µg/ml.{45415} Lupulone (40 µg/ml) activates the extrinsic apoptotic death pathway in SW480 and SW620 colon cancer cells.{45416}
Brand:CaymanSKU:28481 - 1 mgAvailable on backorder
Lupulone is a beta-acid that has been found in the hop plant, H. lupulus, and has diverse biological activities, including antibacterial, antioxidant, and anticarcinogenic properties.{45412,45413,45416} Lupulone is active against B. subtilis and S. aureus (MICs = 1 and 1.2 µg/ml, respectively), as well as T. b. brucei and L. m. mexicana (IC50s = 0.9 and 4.7 µg/ml, respectively).{45412,45413} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in a cell-free assay and inhibits lipid peroxidation in rat brain homogenates (IC50s = 25 and 39 µM, respectively).{45414} It reduces proliferation, migration, and capillary tube formation in human umbilical vein endothelial cells (HUVECs) when used at concentrations ranging from 2.5 to 50 µg/ml.{45415} Lupulone (40 µg/ml) activates the extrinsic apoptotic death pathway in SW480 and SW620 colon cancer cells.{45416}
Brand:CaymanSKU:28481 - 10 mgAvailable on backorder
Lupulone is a beta-acid that has been found in the hop plant, H. lupulus, and has diverse biological activities, including antibacterial, antioxidant, and anticarcinogenic properties.{45412,45413,45416} Lupulone is active against B. subtilis and S. aureus (MICs = 1 and 1.2 µg/ml, respectively), as well as T. b. brucei and L. m. mexicana (IC50s = 0.9 and 4.7 µg/ml, respectively).{45412,45413} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in a cell-free assay and inhibits lipid peroxidation in rat brain homogenates (IC50s = 25 and 39 µM, respectively).{45414} It reduces proliferation, migration, and capillary tube formation in human umbilical vein endothelial cells (HUVECs) when used at concentrations ranging from 2.5 to 50 µg/ml.{45415} Lupulone (40 µg/ml) activates the extrinsic apoptotic death pathway in SW480 and SW620 colon cancer cells.{45416}
Brand:CaymanSKU:28481 - 5 mgAvailable on backorder
Lurasidone is an atypical antipsychotic that binds to dopamine D2, serotonin (5-HT) receptor subtypes 5-HT2A, 5-HT1A, and 5-HT7, and α2C-adrenergic receptors (Kis = 1.68, 2.03, 6.75, 0.495, and 10.8 nM, respectively).{42146} In vivo, pre-training administration of lurasidone (1 and 3 mg/kg) reverses impairment in step-through latency and passive avoidance in a foot shock test induced by MK-801 (Item No. 10009019) in rats. It reverses MK-801-induced learning impairment in the Morris water maze as well as reference and working memory impairment in the radial arm maze in rats.{42147} Lurasidone also decreases immobility in the tail suspension and forced swim tests, indicating antidepressant-like activity in mice.{42148} Formulations containing lurasidone have been used in the treatment of schizophrenia and mood disorders.
Brand:CaymanSKU:9000570 - 1 mgAvailable on backorder
Lurasidone is an atypical antipsychotic that binds to dopamine D2, serotonin (5-HT) receptor subtypes 5-HT2A, 5-HT1A, and 5-HT7, and α2C-adrenergic receptors (Kis = 1.68, 2.03, 6.75, 0.495, and 10.8 nM, respectively).{42146} In vivo, pre-training administration of lurasidone (1 and 3 mg/kg) reverses impairment in step-through latency and passive avoidance in a foot shock test induced by MK-801 (Item No. 10009019) in rats. It reverses MK-801-induced learning impairment in the Morris water maze as well as reference and working memory impairment in the radial arm maze in rats.{42147} Lurasidone also decreases immobility in the tail suspension and forced swim tests, indicating antidepressant-like activity in mice.{42148} Formulations containing lurasidone have been used in the treatment of schizophrenia and mood disorders.
Brand:CaymanSKU:9000570 - 10 mgAvailable on backorder
Lurasidone is an atypical antipsychotic that binds to dopamine D2, serotonin (5-HT) receptor subtypes 5-HT2A, 5-HT1A, and 5-HT7, and α2C-adrenergic receptors (Kis = 1.68, 2.03, 6.75, 0.495, and 10.8 nM, respectively).{42146} In vivo, pre-training administration of lurasidone (1 and 3 mg/kg) reverses impairment in step-through latency and passive avoidance in a foot shock test induced by MK-801 (Item No. 10009019) in rats. It reverses MK-801-induced learning impairment in the Morris water maze as well as reference and working memory impairment in the radial arm maze in rats.{42147} Lurasidone also decreases immobility in the tail suspension and forced swim tests, indicating antidepressant-like activity in mice.{42148} Formulations containing lurasidone have been used in the treatment of schizophrenia and mood disorders.
Brand:CaymanSKU:9000570 - 25 mgAvailable on backorder
Lurasidone is an atypical antipsychotic that binds to dopamine D2, serotonin (5-HT) receptor subtypes 5-HT2A, 5-HT1A, and 5-HT7, and α2C-adrenergic receptors (Kis = 1.68, 2.03, 6.75, 0.495, and 10.8 nM, respectively).{42146} In vivo, pre-training administration of lurasidone (1 and 3 mg/kg) reverses impairment in step-through latency and passive avoidance in a foot shock test induced by MK-801 (Item No. 10009019) in rats. It reverses MK-801-induced learning impairment in the Morris water maze as well as reference and working memory impairment in the radial arm maze in rats.{42147} Lurasidone also decreases immobility in the tail suspension and forced swim tests, indicating antidepressant-like activity in mice.{42148} Formulations containing lurasidone have been used in the treatment of schizophrenia and mood disorders.
Brand:CaymanSKU:9000570 - 5 mgAvailable on backorder
Lurasidone metabolite 14283 is an active metabolite of the atypical antipsychotic lurasidone (Item No. 9000570).{43587}
Brand:CaymanSKU:26651 - 1 mgAvailable on backorder
Lurasidone metabolite 14326 is an active metabolite of the atypical antipsychotic lurasidone (Item No. 9000570).{49005}
Brand:CaymanSKU:26652 - 1 mgAvailable on backorder
Lurasidone metabolite 14326 is an active metabolite of the atypical antipsychotic lurasidone (Item No. 9000570).{49005}
Brand:CaymanSKU:26652 - 500 µgAvailable on backorder
Lurasidone-d8 is intended for use as an internal standard for the quantification of lurasidone (Item No. 9000570) by GC- or LC-MS. Lurasidone is an atypical antipsychotic that binds to dopamine D2, serotonin (5-HT) receptor subtypes 5-HT2A, 5-HT1A, and 5-HT7, and α2C-adrenergic receptors (Kis = 1.68, 2.03, 6.75, 0.495, and 10.8 nM, respectively).{42146} In vivo, pre-training administration of lurasidone (1 and 3 mg/kg) reverses impairment in step-through latency and passive avoidance in a foot shock test induced by MK-801 (Item No. 10009019) in rats. It reverses MK-801-induced learning impairment in the Morris water maze as well as reference and working memory impairment in the radial arm maze in rats.{42147} Lurasidone also decreases immobility in the tail suspension and forced swim tests, indicating antidepressant-like activity in mice.{42148} Formulations containing lurasidone have been used in the treatment of schizophrenia and mood disorders.
Brand:CaymanSKU:25222 - 1 mgAvailable on backorder
Lusutrombopag is an agonist of the thrombopoietin receptor.{45125} It induces proliferation of Ba/F3 cells expressing human MPL, the gene for the thrombopoietin receptor, with an EC50 value of 84 nM but not of those expressing mouse Mpl.{45126} Lusutrombopag (0.3-10 mg/kg per day) increases the number of circulating platelets in a transgenic mouse model expressing human MPL and increases the number of megakaryocytes in the bone marrow when administered at a dose of 10 mg/kg per day. Formulations containing lusutrombopag have been used in the treatment of thrombocytopenia in adult patients with chronic liver disease scheduled to undergo invasive procedures.
Brand:CaymanSKU:26533 - 1 mgAvailable on backorder
Lusutrombopag is an agonist of the thrombopoietin receptor.{45125} It induces proliferation of Ba/F3 cells expressing human MPL, the gene for the thrombopoietin receptor, with an EC50 value of 84 nM but not of those expressing mouse Mpl.{45126} Lusutrombopag (0.3-10 mg/kg per day) increases the number of circulating platelets in a transgenic mouse model expressing human MPL and increases the number of megakaryocytes in the bone marrow when administered at a dose of 10 mg/kg per day. Formulations containing lusutrombopag have been used in the treatment of thrombocytopenia in adult patients with chronic liver disease scheduled to undergo invasive procedures.
Brand:CaymanSKU:26533 - 10 mgAvailable on backorder
Lusutrombopag is an agonist of the thrombopoietin receptor.{45125} It induces proliferation of Ba/F3 cells expressing human MPL, the gene for the thrombopoietin receptor, with an EC50 value of 84 nM but not of those expressing mouse Mpl.{45126} Lusutrombopag (0.3-10 mg/kg per day) increases the number of circulating platelets in a transgenic mouse model expressing human MPL and increases the number of megakaryocytes in the bone marrow when administered at a dose of 10 mg/kg per day. Formulations containing lusutrombopag have been used in the treatment of thrombocytopenia in adult patients with chronic liver disease scheduled to undergo invasive procedures.
Brand:CaymanSKU:26533 - 5 mgAvailable on backorder
Lusutrombopag is an agonist of the thrombopoietin receptor.{45125} It induces proliferation of Ba/F3 cells expressing human MPL, the gene for the thrombopoietin receptor, with an EC50 value of 84 nM but not of those expressing mouse Mpl.{45126} Lusutrombopag (0.3-10 mg/kg per day) increases the number of circulating platelets in a transgenic mouse model expressing human MPL and increases the number of megakaryocytes in the bone marrow when administered at a dose of 10 mg/kg per day. Formulations containing lusutrombopag have been used in the treatment of thrombocytopenia in adult patients with chronic liver disease scheduled to undergo invasive procedures.
Brand:CaymanSKU:26533 - 50 mgAvailable on backorder
Lutein is a dietary carotenoid that has been found in eggs and yellow-colored fruits and vegetables and has diverse biological activities.{56228,56230,56229,56231} It reduces hyperglycemia-induced mitochondrial DNA damage and production of reactive oxygen species (ROS) and promotes mitochondrial biogenesis in ARPE-19 cells when used at a concentration of 10 µM.{56228} Lutein (20 mg/kg) increases nitric oxide (NO) production and decreases serum levels of endothelin-1 (Item No. 24127) in a rat model of hyperhomocysteinemia.{56230} Dietary administration of lutein (0.2%) decreases monocyte migration and lesion size in an ApoE-/- and Ldlr-/- mouse models of atherosclerosis. Lutein reduces infarct size and cardiac malondialdehyde (MDA), lactate dehydrogenase (LDH), and troponin T levels, and increases cardiac levels of catalase (CAT), superoxide dismutase (SOD), heme oxygenase-1 (HO-1), and Nrf2 in a rat model of heart failure induced by isoproterenol (Item No. 15592).{56229} It forms a retinal pigment in human eyes, and high dietary intake of lutein is positively correlated with reduced risk of age-related macular degeneration and cataracts in humans.{56231}
Brand:CaymanSKU:10010811 - 1 mgAvailable on backorder
Lutein is a dietary carotenoid that has been found in eggs and yellow-colored fruits and vegetables and has diverse biological activities.{56228,56230,56229,56231} It reduces hyperglycemia-induced mitochondrial DNA damage and production of reactive oxygen species (ROS) and promotes mitochondrial biogenesis in ARPE-19 cells when used at a concentration of 10 µM.{56228} Lutein (20 mg/kg) increases nitric oxide (NO) production and decreases serum levels of endothelin-1 (Item No. 24127) in a rat model of hyperhomocysteinemia.{56230} Dietary administration of lutein (0.2%) decreases monocyte migration and lesion size in an ApoE-/- and Ldlr-/- mouse models of atherosclerosis. Lutein reduces infarct size and cardiac malondialdehyde (MDA), lactate dehydrogenase (LDH), and troponin T levels, and increases cardiac levels of catalase (CAT), superoxide dismutase (SOD), heme oxygenase-1 (HO-1), and Nrf2 in a rat model of heart failure induced by isoproterenol (Item No. 15592).{56229} It forms a retinal pigment in human eyes, and high dietary intake of lutein is positively correlated with reduced risk of age-related macular degeneration and cataracts in humans.{56231}
Brand:CaymanSKU:10010811 - 10 mgAvailable on backorder
Lutein is a dietary carotenoid that has been found in eggs and yellow-colored fruits and vegetables and has diverse biological activities.{56228,56230,56229,56231} It reduces hyperglycemia-induced mitochondrial DNA damage and production of reactive oxygen species (ROS) and promotes mitochondrial biogenesis in ARPE-19 cells when used at a concentration of 10 µM.{56228} Lutein (20 mg/kg) increases nitric oxide (NO) production and decreases serum levels of endothelin-1 (Item No. 24127) in a rat model of hyperhomocysteinemia.{56230} Dietary administration of lutein (0.2%) decreases monocyte migration and lesion size in an ApoE-/- and Ldlr-/- mouse models of atherosclerosis. Lutein reduces infarct size and cardiac malondialdehyde (MDA), lactate dehydrogenase (LDH), and troponin T levels, and increases cardiac levels of catalase (CAT), superoxide dismutase (SOD), heme oxygenase-1 (HO-1), and Nrf2 in a rat model of heart failure induced by isoproterenol (Item No. 15592).{56229} It forms a retinal pigment in human eyes, and high dietary intake of lutein is positively correlated with reduced risk of age-related macular degeneration and cataracts in humans.{56231}
Brand:CaymanSKU:10010811 - 25 mgAvailable on backorder
Lutein is a dietary carotenoid that has been found in eggs and yellow-colored fruits and vegetables and has diverse biological activities.{56228,56230,56229,56231} It reduces hyperglycemia-induced mitochondrial DNA damage and production of reactive oxygen species (ROS) and promotes mitochondrial biogenesis in ARPE-19 cells when used at a concentration of 10 µM.{56228} Lutein (20 mg/kg) increases nitric oxide (NO) production and decreases serum levels of endothelin-1 (Item No. 24127) in a rat model of hyperhomocysteinemia.{56230} Dietary administration of lutein (0.2%) decreases monocyte migration and lesion size in an ApoE-/- and Ldlr-/- mouse models of atherosclerosis. Lutein reduces infarct size and cardiac malondialdehyde (MDA), lactate dehydrogenase (LDH), and troponin T levels, and increases cardiac levels of catalase (CAT), superoxide dismutase (SOD), heme oxygenase-1 (HO-1), and Nrf2 in a rat model of heart failure induced by isoproterenol (Item No. 15592).{56229} It forms a retinal pigment in human eyes, and high dietary intake of lutein is positively correlated with reduced risk of age-related macular degeneration and cataracts in humans.{56231}
Brand:CaymanSKU:10010811 - 5 mgAvailable on backorder
Luteinizing hormone (LH) is a glycoprotein produced by the pituitary gland and consists of two subunits with a total molecular mass of approximately 30 kDa. The α-subunit is identical to the α-subunit of other pituitary hormones, such follicle stimulating hormone (FSH), thyroid stimulating hormone (TSH), and chorionic gonadotropin (hCG). The β-subunit is unique to LH and confers the specific biological activity to the molecule. Luteinizing hormone stimulates ovulation and the development of the corpus luteum, and maintains the function of the corpus luteum during the first two weeks of pregnancy. In males, LH stimulates the production of testosterone by the testis. Cayman’s Luteinizing Hormone ELISA (human) Kit is an immunometric (i.e., sandwich) ELISA which can be used to measure luteinizing hormone within the range of 0.5-200 mIU/ml. This assay offers specific and sensitive analysis of LH in human serum and has not been validated for other types of samples.
Brand:CaymanSKU:500720 - 96 wellsAvailable on backorder
Luteolin is a polyphenolic flavone found in many plants including soybeans and perilla leaves.{11740} Luteolin is one of the most potent flavanoid inhibitors of soybean and reticulocyte 15-lipoxygenases, with an IC50 of 0.6 µM.{11260} Luteolin has also been found to inhibit the release of TNFα from neutrophils, and to inhibit matrix metalloproteinases.{11743}
Brand:CaymanSKU:10004161 - 10 mgAvailable on backorder
Luteolin is a polyphenolic flavone found in many plants including soybeans and perilla leaves.{11740} Luteolin is one of the most potent flavanoid inhibitors of soybean and reticulocyte 15-lipoxygenases, with an IC50 of 0.6 µM.{11260} Luteolin has also been found to inhibit the release of TNFα from neutrophils, and to inhibit matrix metalloproteinases.{11743}
Brand:CaymanSKU:10004161 - 100 mgAvailable on backorder
Luteolin is a polyphenolic flavone found in many plants including soybeans and perilla leaves.{11740} Luteolin is one of the most potent flavanoid inhibitors of soybean and reticulocyte 15-lipoxygenases, with an IC50 of 0.6 µM.{11260} Luteolin has also been found to inhibit the release of TNFα from neutrophils, and to inhibit matrix metalloproteinases.{11743}
Brand:CaymanSKU:10004161 - 50 mgAvailable on backorder
Luteolin is a polyphenolic flavone found in many plants including soybeans and perilla leaves.{11740} Luteolin is one of the most potent flavanoid inhibitors of soybean and reticulocyte 15-lipoxygenases, with an IC50 of 0.6 µM.{11260} Luteolin has also been found to inhibit the release of TNFα from neutrophils, and to inhibit matrix metalloproteinases.{11743}
Brand:CaymanSKU:10004161 - 500 mgAvailable on backorder
Luteoreticulin is a nitro-containing bacterial metabolite originally isolated from S. luteoreticuli.{43157} It has mosquitocidal activity against A. aegypti when used at a concentration of 6.25 mg/L and nematocidal activity against C. elegans.{43156}
Brand:CaymanSKU:25515 - 2.5 mgAvailable on backorder
Luteoreticulin is a nitro-containing bacterial metabolite originally isolated from S. luteoreticuli.{43157} It has mosquitocidal activity against A. aegypti when used at a concentration of 6.25 mg/L and nematocidal activity against C. elegans.{43156}
Brand:CaymanSKU:25515 - 500 µgAvailable on backorder
In addition to intrinsic antioxidant activities, melatonin (Item No. 14427) evokes its effects through the G protein-coupled receptors MT1A (MT1) and MT1B (MT2).{26016} Luzindole is a melatonin receptor antagonist that preferentially targets MT1B over MT1A (Ki values are = 10-27 and 158-513 nM, respectively).{26020,26015,26017} Luzindole is used both in vitro and in vivo to evaluate the roles of melatonin receptor signaling in diverse pathways, including circadian rhythms, animal behavior, and melanophore response.{26018,26019,26020}
Brand:CaymanSKU:- In addition to intrinsic antioxidant activities, melatonin (Item No. 14427) evokes its effects through the G protein-coupled receptors MT1A (MT1) and MT1B (MT2).{26016} Luzindole is a melatonin receptor antagonist that preferentially targets MT1B over MT1A (Ki values are = 10-27 and 158-513 nM, respectively).{26020,26015,26017} Luzindole is used both in vitro and in vivo to evaluate the roles of melatonin receptor signaling in diverse pathways, including circadian rhythms, animal behavior, and melanophore response.{26018,26019,26020}
Brand:CaymanSKU:- In addition to intrinsic antioxidant activities, melatonin (Item No. 14427) evokes its effects through the G protein-coupled receptors MT1A (MT1) and MT1B (MT2).{26016} Luzindole is a melatonin receptor antagonist that preferentially targets MT1B over MT1A (Ki values are = 10-27 and 158-513 nM, respectively).{26020,26015,26017} Luzindole is used both in vitro and in vivo to evaluate the roles of melatonin receptor signaling in diverse pathways, including circadian rhythms, animal behavior, and melanophore response.{26018,26019,26020}
Brand:CaymanSKU:- In addition to intrinsic antioxidant activities, melatonin (Item No. 14427) evokes its effects through the G protein-coupled receptors MT1A (MT1) and MT1B (MT2).{26016} Luzindole is a melatonin receptor antagonist that preferentially targets MT1B over MT1A (Ki values are = 10-27 and 158-513 nM, respectively).{26020,26015,26017} Luzindole is used both in vitro and in vivo to evaluate the roles of melatonin receptor signaling in diverse pathways, including circadian rhythms, animal behavior, and melanophore response.{26018,26019,26020}
Brand:CaymanSKU:-
Luzopeptin A is a cyclic depsipeptide antibiotic first isolated from an actinomycete strain.{29678,29676} It displays antitumor activity, as it is highly active in mice against a variety of experimental tumors.{29678} Luzopeptin A acts as a bifunctional DNA intercalator that strongly binds DNA and forms crosslinks between DNA molecules.{29675} It also inhibits reverse transcriptases from HIV-1 and HIV-2 (IC50s = 7 and 68 nM, respectively), as well as cellular DNA polymerases.{29677,29679}
Brand:CaymanSKU:-Available on backorder
Luzopeptin A is a cyclic depsipeptide antibiotic first isolated from an actinomycete strain.{29678,29676} It displays antitumor activity, as it is highly active in mice against a variety of experimental tumors.{29678} Luzopeptin A acts as a bifunctional DNA intercalator that strongly binds DNA and forms crosslinks between DNA molecules.{29675} It also inhibits reverse transcriptases from HIV-1 and HIV-2 (IC50s = 7 and 68 nM, respectively), as well as cellular DNA polymerases.{29677,29679}
Brand:CaymanSKU:-Available on backorder
LX2343 is an inhibitor of β-site amyloid protein cleaving enzyme 1 (BACE1/β-secretase; IC50 = 11.43 μM) and PI3K (IC50 = 15.99 μM).{47505} It inhibits accumulation of Aβ (1-40) (Aβ40) and Aβ42 induced by streptozotocin (STZ; Item No. 13104) in both HEK293-APPSW and CHO-APP cells, which express mutant and wild-type amyloid precursor protein (APP), respectively, in a concentration-dependent manner. It also inhibits STZ-induced increases in JNK and APPThr668 phosphorylation as well as soluble APPβ (sAPPβ) protein levels. LX2343 (10 mg/kg per day) reduces levels of Aβ40 and Aβ42, as well as thioflavine S staining, in the cortex and hippocampus in the APP/PS1 transgenic mouse model of Alzheimer’s disease. It also reduces cortical levels of PI3K, Akt, and mTOR phosphorylation and accumulation of the autophagy substrate p62, indicating increased autophagy. LX2343 (10 mg/kg per day) decreases path length and escape latency time in the Morris water maze in APP/PS1 mice.
Brand:CaymanSKU:27799 - 1 mgAvailable on backorder
LX2343 is an inhibitor of β-site amyloid protein cleaving enzyme 1 (BACE1/β-secretase; IC50 = 11.43 μM) and PI3K (IC50 = 15.99 μM).{47505} It inhibits accumulation of Aβ (1-40) (Aβ40) and Aβ42 induced by streptozotocin (STZ; Item No. 13104) in both HEK293-APPSW and CHO-APP cells, which express mutant and wild-type amyloid precursor protein (APP), respectively, in a concentration-dependent manner. It also inhibits STZ-induced increases in JNK and APPThr668 phosphorylation as well as soluble APPβ (sAPPβ) protein levels. LX2343 (10 mg/kg per day) reduces levels of Aβ40 and Aβ42, as well as thioflavine S staining, in the cortex and hippocampus in the APP/PS1 transgenic mouse model of Alzheimer’s disease. It also reduces cortical levels of PI3K, Akt, and mTOR phosphorylation and accumulation of the autophagy substrate p62, indicating increased autophagy. LX2343 (10 mg/kg per day) decreases path length and escape latency time in the Morris water maze in APP/PS1 mice.
Brand:CaymanSKU:27799 - 10 mgAvailable on backorder
LX2343 is an inhibitor of β-site amyloid protein cleaving enzyme 1 (BACE1/β-secretase; IC50 = 11.43 μM) and PI3K (IC50 = 15.99 μM).{47505} It inhibits accumulation of Aβ (1-40) (Aβ40) and Aβ42 induced by streptozotocin (STZ; Item No. 13104) in both HEK293-APPSW and CHO-APP cells, which express mutant and wild-type amyloid precursor protein (APP), respectively, in a concentration-dependent manner. It also inhibits STZ-induced increases in JNK and APPThr668 phosphorylation as well as soluble APPβ (sAPPβ) protein levels. LX2343 (10 mg/kg per day) reduces levels of Aβ40 and Aβ42, as well as thioflavine S staining, in the cortex and hippocampus in the APP/PS1 transgenic mouse model of Alzheimer’s disease. It also reduces cortical levels of PI3K, Akt, and mTOR phosphorylation and accumulation of the autophagy substrate p62, indicating increased autophagy. LX2343 (10 mg/kg per day) decreases path length and escape latency time in the Morris water maze in APP/PS1 mice.
Brand:CaymanSKU:27799 - 5 mgAvailable on backorder
LX7101 is a potent inhibitor of LIM kinase (LIMK) 1 and 2 and Rho-associated kinase 1 (ROCK-1) and ROCK-2 with IC50 values of 32, 4.3, 69, and 32 nM, respectively.{38221} It is selective, showing no cross reactivity in a panel of binding assays including 78 receptors and transporters and 430 additional kinases, at a concentration of 10 μM. Topical administration (3 μl of 1 mg/ml solution) of LX7101 to the eye reduces intraocular pressure in a dexamethasone-induced mouse model of glaucoma.
Brand:CaymanSKU:21209 -Out of stock
LX7101 is a potent inhibitor of LIM kinase (LIMK) 1 and 2 and Rho-associated kinase 1 (ROCK-1) and ROCK-2 with IC50 values of 32, 4.3, 69, and 32 nM, respectively.{38221} It is selective, showing no cross reactivity in a panel of binding assays including 78 receptors and transporters and 430 additional kinases, at a concentration of 10 μM. Topical administration (3 μl of 1 mg/ml solution) of LX7101 to the eye reduces intraocular pressure in a dexamethasone-induced mouse model of glaucoma.
Brand:CaymanSKU:21209 -Out of stock
LX7101 is a potent inhibitor of LIM kinase (LIMK) 1 and 2 and Rho-associated kinase 1 (ROCK-1) and ROCK-2 with IC50 values of 32, 4.3, 69, and 32 nM, respectively.{38221} It is selective, showing no cross reactivity in a panel of binding assays including 78 receptors and transporters and 430 additional kinases, at a concentration of 10 μM. Topical administration (3 μl of 1 mg/ml solution) of LX7101 to the eye reduces intraocular pressure in a dexamethasone-induced mouse model of glaucoma.
Brand:CaymanSKU:21209 -Out of stock