Cayman

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  • Lignoceroyl ethanolamide is a member of the family of fatty N-acyl ethanolamines collectively called endocannabinoids.{1202,1712,13153} Whereas lignoceric acid has been detected at relatively high levels in rat cerebrospinal fluid, the specific role and relative importance of its ethanolamine metabolite have not been determined.{22439}  

     

    Brand:
    Cayman
    SKU:9001744 - 10 mg

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  • Lignoceroyl ethanolamide is a member of the family of fatty N-acyl ethanolamines collectively called endocannabinoids.{1202,1712,13153} Whereas lignoceric acid has been detected at relatively high levels in rat cerebrospinal fluid, the specific role and relative importance of its ethanolamine metabolite have not been determined.{22439}  

     

    Brand:
    Cayman
    SKU:9001744 - 100 mg

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  • Lignoceroyl ethanolamide is a member of the family of fatty N-acyl ethanolamines collectively called endocannabinoids.{1202,1712,13153} Whereas lignoceric acid has been detected at relatively high levels in rat cerebrospinal fluid, the specific role and relative importance of its ethanolamine metabolite have not been determined.{22439}  

     

    Brand:
    Cayman
    SKU:9001744 - 5 mg

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  • Lignoceroyl ethanolamide is a member of the family of fatty N-acyl ethanolamines collectively called endocannabinoids.{1202,1712,13153} Whereas lignoceric acid has been detected at relatively high levels in rat cerebrospinal fluid, the specific role and relative importance of its ethanolamine metabolite have not been determined.{22439}  

     

    Brand:
    Cayman
    SKU:9001744 - 50 mg

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  • Ligustrazine is a compound that has been found in L. wallichii and has diverse biological activities, including antioxidant, anti-inflammatory, neuroprotective, and anticancer properties.{46728,46727,46729} It inhibits hydrogen peroxide-induced decreases in cell viability and the levels of superoxide dismutase (SOD) and glutathione peroxidase (GPX) and increases in reactive oxygen species (ROS) and malondialdehyde (MDA) levels in human umbilical vein endothelial cells (HUVECs) when used at concentrations of 100 and 150 μg/ml.{46728} Ligustrazine (50 and 100 μM) inhibits prostaglandin E2 (PGE2; Item No. 14010) production induced by LPS and IFN-γ in primary rat glia.{46727} It reduces infarct volume, cortical edema, and cortical PGE2 levels in a rat model of transient focal cerebral ischemia induced by common carotid artery and middle cerebral artery occlusion when administered at a dose of 20 mg/kg. Ligustrazine inhibits the proliferation of MG-63, Saos-2, and U2OS osteosarcoma cells (IC50s = 10.3, 24.7, and 54.7 mg/ml, respectively) in vitro and reduces tumor growth in an MG-63 mouse xenograft model when administered at a dose of 100 mg/kg every other day.{46729}  

     

    Brand:
    Cayman
    SKU:29658 - 100 mg

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  • Ligustrazine is a compound that has been found in L. wallichii and has diverse biological activities, including antioxidant, anti-inflammatory, neuroprotective, and anticancer properties.{46728,46727,46729} It inhibits hydrogen peroxide-induced decreases in cell viability and the levels of superoxide dismutase (SOD) and glutathione peroxidase (GPX) and increases in reactive oxygen species (ROS) and malondialdehyde (MDA) levels in human umbilical vein endothelial cells (HUVECs) when used at concentrations of 100 and 150 μg/ml.{46728} Ligustrazine (50 and 100 μM) inhibits prostaglandin E2 (PGE2; Item No. 14010) production induced by LPS and IFN-γ in primary rat glia.{46727} It reduces infarct volume, cortical edema, and cortical PGE2 levels in a rat model of transient focal cerebral ischemia induced by common carotid artery and middle cerebral artery occlusion when administered at a dose of 20 mg/kg. Ligustrazine inhibits the proliferation of MG-63, Saos-2, and U2OS osteosarcoma cells (IC50s = 10.3, 24.7, and 54.7 mg/ml, respectively) in vitro and reduces tumor growth in an MG-63 mouse xenograft model when administered at a dose of 100 mg/kg every other day.{46729}  

     

    Brand:
    Cayman
    SKU:29658 - 250 mg

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  • Ligustrazine is a compound that has been found in L. wallichii and has diverse biological activities, including antioxidant, anti-inflammatory, neuroprotective, and anticancer properties.{46728,46727,46729} It inhibits hydrogen peroxide-induced decreases in cell viability and the levels of superoxide dismutase (SOD) and glutathione peroxidase (GPX) and increases in reactive oxygen species (ROS) and malondialdehyde (MDA) levels in human umbilical vein endothelial cells (HUVECs) when used at concentrations of 100 and 150 μg/ml.{46728} Ligustrazine (50 and 100 μM) inhibits prostaglandin E2 (PGE2; Item No. 14010) production induced by LPS and IFN-γ in primary rat glia.{46727} It reduces infarct volume, cortical edema, and cortical PGE2 levels in a rat model of transient focal cerebral ischemia induced by common carotid artery and middle cerebral artery occlusion when administered at a dose of 20 mg/kg. Ligustrazine inhibits the proliferation of MG-63, Saos-2, and U2OS osteosarcoma cells (IC50s = 10.3, 24.7, and 54.7 mg/ml, respectively) in vitro and reduces tumor growth in an MG-63 mouse xenograft model when administered at a dose of 100 mg/kg every other day.{46729}  

     

    Brand:
    Cayman
    SKU:29658 - 50 mg

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  • Ligustrazine is a compound that has been found in L. wallichii and has diverse biological activities, including antioxidant, anti-inflammatory, neuroprotective, and anticancer properties.{46728,46727,46729} It inhibits hydrogen peroxide-induced decreases in cell viability and the levels of superoxide dismutase (SOD) and glutathione peroxidase (GPX) and increases in reactive oxygen species (ROS) and malondialdehyde (MDA) levels in human umbilical vein endothelial cells (HUVECs) when used at concentrations of 100 and 150 μg/ml.{46728} Ligustrazine (50 and 100 μM) inhibits prostaglandin E2 (PGE2; Item No. 14010) production induced by LPS and IFN-γ in primary rat glia.{46727} It reduces infarct volume, cortical edema, and cortical PGE2 levels in a rat model of transient focal cerebral ischemia induced by common carotid artery and middle cerebral artery occlusion when administered at a dose of 20 mg/kg. Ligustrazine inhibits the proliferation of MG-63, Saos-2, and U2OS osteosarcoma cells (IC50s = 10.3, 24.7, and 54.7 mg/ml, respectively) in vitro and reduces tumor growth in an MG-63 mouse xenograft model when administered at a dose of 100 mg/kg every other day.{46729}  

     

    Brand:
    Cayman
    SKU:29658 - 500 mg

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  • Ligustroflavone is an apigenin triglycoside originally isolated from L. vulgare that has diverse biological activities.{48423} It increases parathyroid hormone (PTH) release from rat primary parathyroid gland cells when used at a concentration of 1 µM and inhibits calcium influx in HEK293 cells.{48424} It increases serum PTH, as well as serum and bone calcium levels, in a streptozotocin-induced mouse model of diabetes with osteoporosis when administered at doses of 5 and 20 mg/kg three times per week. It also reduces increases in the expression and levels of the extracellular calcium sensing receptor (CaSR) in the kidney of diabetic osteoporotic mice. Ligustroflavone (10, 30, and 60 mg/kg) decreases infarct volume in a rat model of ischemic stroke and decreases the levels of the necroptosis-associated proteins RIPK3 and MLKL in the brain of ischemic rats when administered at a dose of 30 mg/kg.{48425}  

     

    Brand:
    Cayman
    SKU:27431 - 1 mg

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  • Ligustroflavone is an apigenin triglycoside originally isolated from L. vulgare that has diverse biological activities.{48423} It increases parathyroid hormone (PTH) release from rat primary parathyroid gland cells when used at a concentration of 1 µM and inhibits calcium influx in HEK293 cells.{48424} It increases serum PTH, as well as serum and bone calcium levels, in a streptozotocin-induced mouse model of diabetes with osteoporosis when administered at doses of 5 and 20 mg/kg three times per week. It also reduces increases in the expression and levels of the extracellular calcium sensing receptor (CaSR) in the kidney of diabetic osteoporotic mice. Ligustroflavone (10, 30, and 60 mg/kg) decreases infarct volume in a rat model of ischemic stroke and decreases the levels of the necroptosis-associated proteins RIPK3 and MLKL in the brain of ischemic rats when administered at a dose of 30 mg/kg.{48425}  

     

    Brand:
    Cayman
    SKU:27431 - 10 mg

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  • Ligustroflavone is an apigenin triglycoside originally isolated from L. vulgare that has diverse biological activities.{48423} It increases parathyroid hormone (PTH) release from rat primary parathyroid gland cells when used at a concentration of 1 µM and inhibits calcium influx in HEK293 cells.{48424} It increases serum PTH, as well as serum and bone calcium levels, in a streptozotocin-induced mouse model of diabetes with osteoporosis when administered at doses of 5 and 20 mg/kg three times per week. It also reduces increases in the expression and levels of the extracellular calcium sensing receptor (CaSR) in the kidney of diabetic osteoporotic mice. Ligustroflavone (10, 30, and 60 mg/kg) decreases infarct volume in a rat model of ischemic stroke and decreases the levels of the necroptosis-associated proteins RIPK3 and MLKL in the brain of ischemic rats when administered at a dose of 30 mg/kg.{48425}  

     

    Brand:
    Cayman
    SKU:27431 - 25 mg

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  • Ligustroflavone is an apigenin triglycoside originally isolated from L. vulgare that has diverse biological activities.{48423} It increases parathyroid hormone (PTH) release from rat primary parathyroid gland cells when used at a concentration of 1 µM and inhibits calcium influx in HEK293 cells.{48424} It increases serum PTH, as well as serum and bone calcium levels, in a streptozotocin-induced mouse model of diabetes with osteoporosis when administered at doses of 5 and 20 mg/kg three times per week. It also reduces increases in the expression and levels of the extracellular calcium sensing receptor (CaSR) in the kidney of diabetic osteoporotic mice. Ligustroflavone (10, 30, and 60 mg/kg) decreases infarct volume in a rat model of ischemic stroke and decreases the levels of the necroptosis-associated proteins RIPK3 and MLKL in the brain of ischemic rats when administered at a dose of 30 mg/kg.{48425}  

     

    Brand:
    Cayman
    SKU:27431 - 5 mg

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  • Limaprost is an analog of PGE1 with structural modifications intended to give it a prolonged half-life and greater potency. Limaprost is orally active in both rats and guinea pigs at doses of 100 µg/kg as an inhibitor of ADP and collagen induced platelet aggregation. Limaprost is 10-1,000 times more potent than PGE1 as an inhibitor of platelet adhesiveness measured in vitro. Intra-coronary injection (100 ng/kg) or intravenous injection (3 µg/kg) in anesthetized dogs causes vasodilation and increased coronary blood flow by 60-80%. Significant hypotensive effects were seen at 100 and 300 µg/kg orally in rats.{6808}  

     

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  • Limaprost is an analog of PGE1 with structural modifications intended to give it a prolonged half-life and greater potency. Limaprost is orally active in both rats and guinea pigs at doses of 100 µg/kg as an inhibitor of ADP and collagen induced platelet aggregation. Limaprost is 10-1,000 times more potent than PGE1 as an inhibitor of platelet adhesiveness measured in vitro. Intra-coronary injection (100 ng/kg) or intravenous injection (3 µg/kg) in anesthetized dogs causes vasodilation and increased coronary blood flow by 60-80%. Significant hypotensive effects were seen at 100 and 300 µg/kg orally in rats.{6808}  

     

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  • Limaprost is an analog of PGE1 with structural modifications intended to give it a prolonged half-life and greater potency. Limaprost is orally active in both rats and guinea pigs at doses of 100 µg/kg as an inhibitor of ADP and collagen induced platelet aggregation. Limaprost is 10-1,000 times more potent than PGE1 as an inhibitor of platelet adhesiveness measured in vitro. Intra-coronary injection (100 ng/kg) or intravenous injection (3 µg/kg) in anesthetized dogs causes vasodilation and increased coronary blood flow by 60-80%. Significant hypotensive effects were seen at 100 and 300 µg/kg orally in rats.{6808}  

     

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  • Limaprost-d3 is intended for use as an internal standard for the quantification of limaprost (Item No. 13810) by GC- or LC-MS. Limaprost is an analog of prostaglandin E1 (PGE1; Item No. 13010) with structural modifications intended to give it a prolonged half-life and greater potency. Limaprost is orally active in both rats and guinea pigs at doses of 100 µg/kg as an inhibitor of ADP and collagen-induced platelet aggregation. Limaprost is 10-1,000 times more potent than PGE1 as an inhibitor of platelet adhesiveness measured in vitro. Intra-coronary injection (100 ng/kg) or intravenous injection (3 µg/kg) in anesthetized dogs causes vasodilation and increased coronary blood flow by 60-80%. Significant hypotensive effects were seen at 100 and 300 µg/kg orally in rats.{6808}  

     

    Brand:
    Cayman
    SKU:25416 - 1 mg

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  • Limaprost-d3 is intended for use as an internal standard for the quantification of limaprost (Item No. 13810) by GC- or LC-MS. Limaprost is an analog of prostaglandin E1 (PGE1; Item No. 13010) with structural modifications intended to give it a prolonged half-life and greater potency. Limaprost is orally active in both rats and guinea pigs at doses of 100 µg/kg as an inhibitor of ADP and collagen-induced platelet aggregation. Limaprost is 10-1,000 times more potent than PGE1 as an inhibitor of platelet adhesiveness measured in vitro. Intra-coronary injection (100 ng/kg) or intravenous injection (3 µg/kg) in anesthetized dogs causes vasodilation and increased coronary blood flow by 60-80%. Significant hypotensive effects were seen at 100 and 300 µg/kg orally in rats.{6808}  

     

    Brand:
    Cayman
    SKU:25416 - 500 µg

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  • Limonin is the first described limonoid, which are naturally occurring tetranortriterpenoids that impart bitter flavor in citrus fruits. Compounds belonging to this group have reported anti-proliferative and proapoptotic activity on several cancer cell lines as well as pesticidal, anti-malarial, anti-microbial, and anti-HIV activity.{27612}  

     

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  • Limonin is the first described limonoid, which are naturally occurring tetranortriterpenoids that impart bitter flavor in citrus fruits. Compounds belonging to this group have reported anti-proliferative and proapoptotic activity on several cancer cell lines as well as pesticidal, anti-malarial, anti-microbial, and anti-HIV activity.{27612}  

     

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    Cayman
    SKU:-

    Out of stock

  • Limonin is the first described limonoid, which are naturally occurring tetranortriterpenoids that impart bitter flavor in citrus fruits. Compounds belonging to this group have reported anti-proliferative and proapoptotic activity on several cancer cell lines as well as pesticidal, anti-malarial, anti-microbial, and anti-HIV activity.{27612}  

     

    Brand:
    Cayman
    SKU:-

    Out of stock

  • Limonin is the first described limonoid, which are naturally occurring tetranortriterpenoids that impart bitter flavor in citrus fruits. Compounds belonging to this group have reported anti-proliferative and proapoptotic activity on several cancer cell lines as well as pesticidal, anti-malarial, anti-microbial, and anti-HIV activity.{27612}  

     

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    Cayman
    SKU:-

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  • Lin28 1632 is a small molecule inhibitor of the interaction between the RNA binding protein Lin28 and let-7 precursor RNA (IC50 = 8 μM in a competition ELISA).{41072} It increases levels of endogenous let-7 miRNAs and decreases Lin28 expression in a dose-dependent manner in murine embryonic stem cells (mESCs). Lin28 1632 inhibits clonogenic growth of 22Rv1, PC3, DU145, and Huh7 cancer cells and decreases tumor-sphere formation by 22Rv1 and Huh7 cells in vitro. It also binds bromodomain-containing protein 4 (BRD4) and CREB-binding protein (CBP/CREBBP) bromodomains (Kds = 7 and 25 μM, respectively).  

     

    Brand:
    Cayman
    SKU:22401 -

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  • Lin28 1632 is a small molecule inhibitor of the interaction between the RNA binding protein Lin28 and let-7 precursor RNA (IC50 = 8 μM in a competition ELISA).{41072} It increases levels of endogenous let-7 miRNAs and decreases Lin28 expression in a dose-dependent manner in murine embryonic stem cells (mESCs). Lin28 1632 inhibits clonogenic growth of 22Rv1, PC3, DU145, and Huh7 cancer cells and decreases tumor-sphere formation by 22Rv1 and Huh7 cells in vitro. It also binds bromodomain-containing protein 4 (BRD4) and CREB-binding protein (CBP/CREBBP) bromodomains (Kds = 7 and 25 μM, respectively).  

     

    Brand:
    Cayman
    SKU:22401 -

    Out of stock

  • Lin28 1632 is a small molecule inhibitor of the interaction between the RNA binding protein Lin28 and let-7 precursor RNA (IC50 = 8 μM in a competition ELISA).{41072} It increases levels of endogenous let-7 miRNAs and decreases Lin28 expression in a dose-dependent manner in murine embryonic stem cells (mESCs). Lin28 1632 inhibits clonogenic growth of 22Rv1, PC3, DU145, and Huh7 cancer cells and decreases tumor-sphere formation by 22Rv1 and Huh7 cells in vitro. It also binds bromodomain-containing protein 4 (BRD4) and CREB-binding protein (CBP/CREBBP) bromodomains (Kds = 7 and 25 μM, respectively).  

     

    Brand:
    Cayman
    SKU:22401 -

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  • Linaclotide is a peptide agonist of the guanylate cyclase C receptor (Ki = 16.4 nM in a radioligand binding assay using mouse intestinal mucosa).{40472} Luminal exposure to 5 μg of linaclotide stimulates fluid secretion and cGMP concentration in jejunal loops isolated from wild-type mice but not guanylate cyclase C receptor-null mice. Linaclotide (100 μg/kg) increases intestinal transit rate in wild-type mice. It also reduces the number of phosphorylated ERK-positive dorsal horn neurons in the thoracolumbar spinal cord, a marker of nociceptive signaling, following noxious colorectal distension and mechanical hypersensitivity in a mouse model of TNBS-induced colitis.{40473} Formulations containing linaclotide have been used for the treatment of constipation and pain associated with irritable bowel syndrome.  

     

    Brand:
    Cayman
    SKU:24085 - 1 mg

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  • Linaclotide is a peptide agonist of the guanylate cyclase C receptor (Ki = 16.4 nM in a radioligand binding assay using mouse intestinal mucosa).{40472} Luminal exposure to 5 μg of linaclotide stimulates fluid secretion and cGMP concentration in jejunal loops isolated from wild-type mice but not guanylate cyclase C receptor-null mice. Linaclotide (100 μg/kg) increases intestinal transit rate in wild-type mice. It also reduces the number of phosphorylated ERK-positive dorsal horn neurons in the thoracolumbar spinal cord, a marker of nociceptive signaling, following noxious colorectal distension and mechanical hypersensitivity in a mouse model of TNBS-induced colitis.{40473} Formulations containing linaclotide have been used for the treatment of constipation and pain associated with irritable bowel syndrome.  

     

    Brand:
    Cayman
    SKU:24085 - 10 mg

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  • Linaclotide is a peptide agonist of the guanylate cyclase C receptor (Ki = 16.4 nM in a radioligand binding assay using mouse intestinal mucosa).{40472} Luminal exposure to 5 μg of linaclotide stimulates fluid secretion and cGMP concentration in jejunal loops isolated from wild-type mice but not guanylate cyclase C receptor-null mice. Linaclotide (100 μg/kg) increases intestinal transit rate in wild-type mice. It also reduces the number of phosphorylated ERK-positive dorsal horn neurons in the thoracolumbar spinal cord, a marker of nociceptive signaling, following noxious colorectal distension and mechanical hypersensitivity in a mouse model of TNBS-induced colitis.{40473} Formulations containing linaclotide have been used for the treatment of constipation and pain associated with irritable bowel syndrome.  

     

    Brand:
    Cayman
    SKU:24085 - 5 mg

    Available on backorder

  • Linaclotide is a peptide agonist of the guanylate cyclase C receptor (Ki = 16.4 nM in a radioligand binding assay using mouse intestinal mucosa).{40472} Luminal exposure to 5 μg of linaclotide stimulates fluid secretion and cGMP concentration in jejunal loops isolated from wild-type mice but not guanylate cyclase C receptor-null mice. Linaclotide (100 μg/kg) increases intestinal transit rate in wild-type mice. It also reduces the number of phosphorylated ERK-positive dorsal horn neurons in the thoracolumbar spinal cord, a marker of nociceptive signaling, following noxious colorectal distension and mechanical hypersensitivity in a mouse model of TNBS-induced colitis.{40473} Formulations containing linaclotide have been used for the treatment of constipation and pain associated with irritable bowel syndrome.  

     

    Brand:
    Cayman
    SKU:24085 - 500 µg

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  • Linagliptin is a potent inhibitor of dipeptidyl peptidase 4 (DPP-4) with an IC50 value of 1 nM for human recombinant DPP-4.{41123} It is selective, with ≥10,000-fold selectivity for DPP-4 over a panel of 11 peptidases and proteases. Linagliptin (3 mg/kg) inhibits 90% of plasma DPP-4 activity in rat. It also dose-dependently decreases plasma glucose and increases plasma levels of glucagon-like peptide 1 (GLP-1) and insulin in Zucker diabetic fatty rats. Oral administration of linagliptin reduces HbA1c levels in mice with high-fat diet- and low-dose streptozotocin-induced diabetes.{41124} Formulations containing linagliptin have been used for the treatment of type 2 diabetes mellitus.{41125}  

     

    Brand:
    Cayman
    SKU:23306 - 1 g

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  • Linagliptin is a potent inhibitor of dipeptidyl peptidase 4 (DPP-4) with an IC50 value of 1 nM for human recombinant DPP-4.{41123} It is selective, with ≥10,000-fold selectivity for DPP-4 over a panel of 11 peptidases and proteases. Linagliptin (3 mg/kg) inhibits 90% of plasma DPP-4 activity in rat. It also dose-dependently decreases plasma glucose and increases plasma levels of glucagon-like peptide 1 (GLP-1) and insulin in Zucker diabetic fatty rats. Oral administration of linagliptin reduces HbA1c levels in mice with high-fat diet- and low-dose streptozotocin-induced diabetes.{41124} Formulations containing linagliptin have been used for the treatment of type 2 diabetes mellitus.{41125}  

     

    Brand:
    Cayman
    SKU:23306 - 100 mg

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  • Linagliptin is a potent inhibitor of dipeptidyl peptidase 4 (DPP-4) with an IC50 value of 1 nM for human recombinant DPP-4.{41123} It is selective, with ≥10,000-fold selectivity for DPP-4 over a panel of 11 peptidases and proteases. Linagliptin (3 mg/kg) inhibits 90% of plasma DPP-4 activity in rat. It also dose-dependently decreases plasma glucose and increases plasma levels of glucagon-like peptide 1 (GLP-1) and insulin in Zucker diabetic fatty rats. Oral administration of linagliptin reduces HbA1c levels in mice with high-fat diet- and low-dose streptozotocin-induced diabetes.{41124} Formulations containing linagliptin have been used for the treatment of type 2 diabetes mellitus.{41125}  

     

    Brand:
    Cayman
    SKU:23306 - 500 mg

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  • Linamarin is a glucoside of acetone cyanohydrin found in the leaves and roots of cassava, lima beans, and flax.{32190} It is thought to function in the transport of nitrogen from plant leaves to roots in young plants but also serves as a plant defense mechanism. Linamarin is converted to toxic hydrocyanic acid or prussic acid when it comes into contact with linamarase, an enzyme that is released when the cells of cassava roots are ruptured.{32189}  

     

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    Cayman
    SKU:20532 -

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  • Linamarin is a glucoside of acetone cyanohydrin found in the leaves and roots of cassava, lima beans, and flax.{32190} It is thought to function in the transport of nitrogen from plant leaves to roots in young plants but also serves as a plant defense mechanism. Linamarin is converted to toxic hydrocyanic acid or prussic acid when it comes into contact with linamarase, an enzyme that is released when the cells of cassava roots are ruptured.{32189}  

     

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    Cayman
    SKU:20532 -

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  • Linamarin is a glucoside of acetone cyanohydrin found in the leaves and roots of cassava, lima beans, and flax.{32190} It is thought to function in the transport of nitrogen from plant leaves to roots in young plants but also serves as a plant defense mechanism. Linamarin is converted to toxic hydrocyanic acid or prussic acid when it comes into contact with linamarase, an enzyme that is released when the cells of cassava roots are ruptured.{32189}  

     

    Brand:
    Cayman
    SKU:20532 -

    Available on backorder

  • Linamarin is a glucoside of acetone cyanohydrin found in the leaves and roots of cassava, lima beans, and flax.{32190} It is thought to function in the transport of nitrogen from plant leaves to roots in young plants but also serves as a plant defense mechanism. Linamarin is converted to toxic hydrocyanic acid or prussic acid when it comes into contact with linamarase, an enzyme that is released when the cells of cassava roots are ruptured.{32189}  

     

    Brand:
    Cayman
    SKU:20532 -

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  • Linarin is a flavonoid glycoside that has been found in various fruits and vegetables and has diverse biological activities.{45217,45218,45219} It potentiates cytotoxicity and apoptosis induced by tumor necrosis factor-related apoptosis-induced ligand (TRAIL) in U87MG human glioma cells.{45217} In vivo, linarin potentiates TRAIL-induced tumor cell apoptosis and reduction of tumor growth in a U87MG mouse xenograft model. Linarin (12.5-50 mg/kg) reduces pulmonary platelet count, edema, and macrophage, polymorphonuclear leukocyte, and lymphocyte infiltration, as well as inhibits TXNIP/NLRP3, MAPK, and NF-κB signaling in a mouse model of LPS-induced acute lung injury.{45218} It also inhibits acetylcholinesterase (AChE) and induces dyskinesia recovery by 74.5 and 88%, respectively, in a zebrafish model of Alzheimer’s disease when administered in tank water at a concentration of 50 μg/ml.{45219}  

     

    Brand:
    Cayman
    SKU:26900 - 10 mg

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  • Linarin is a flavonoid glycoside that has been found in various fruits and vegetables and has diverse biological activities.{45217,45218,45219} It potentiates cytotoxicity and apoptosis induced by tumor necrosis factor-related apoptosis-induced ligand (TRAIL) in U87MG human glioma cells.{45217} In vivo, linarin potentiates TRAIL-induced tumor cell apoptosis and reduction of tumor growth in a U87MG mouse xenograft model. Linarin (12.5-50 mg/kg) reduces pulmonary platelet count, edema, and macrophage, polymorphonuclear leukocyte, and lymphocyte infiltration, as well as inhibits TXNIP/NLRP3, MAPK, and NF-κB signaling in a mouse model of LPS-induced acute lung injury.{45218} It also inhibits acetylcholinesterase (AChE) and induces dyskinesia recovery by 74.5 and 88%, respectively, in a zebrafish model of Alzheimer’s disease when administered in tank water at a concentration of 50 μg/ml.{45219}  

     

    Brand:
    Cayman
    SKU:26900 - 25 mg

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  • Linarin is a flavonoid glycoside that has been found in various fruits and vegetables and has diverse biological activities.{45217,45218,45219} It potentiates cytotoxicity and apoptosis induced by tumor necrosis factor-related apoptosis-induced ligand (TRAIL) in U87MG human glioma cells.{45217} In vivo, linarin potentiates TRAIL-induced tumor cell apoptosis and reduction of tumor growth in a U87MG mouse xenograft model. Linarin (12.5-50 mg/kg) reduces pulmonary platelet count, edema, and macrophage, polymorphonuclear leukocyte, and lymphocyte infiltration, as well as inhibits TXNIP/NLRP3, MAPK, and NF-κB signaling in a mouse model of LPS-induced acute lung injury.{45218} It also inhibits acetylcholinesterase (AChE) and induces dyskinesia recovery by 74.5 and 88%, respectively, in a zebrafish model of Alzheimer’s disease when administered in tank water at a concentration of 50 μg/ml.{45219}  

     

    Brand:
    Cayman
    SKU:26900 - 5 mg

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  • Linarin is a flavonoid glycoside that has been found in various fruits and vegetables and has diverse biological activities.{45217,45218,45219} It potentiates cytotoxicity and apoptosis induced by tumor necrosis factor-related apoptosis-induced ligand (TRAIL) in U87MG human glioma cells.{45217} In vivo, linarin potentiates TRAIL-induced tumor cell apoptosis and reduction of tumor growth in a U87MG mouse xenograft model. Linarin (12.5-50 mg/kg) reduces pulmonary platelet count, edema, and macrophage, polymorphonuclear leukocyte, and lymphocyte infiltration, as well as inhibits TXNIP/NLRP3, MAPK, and NF-κB signaling in a mouse model of LPS-induced acute lung injury.{45218} It also inhibits acetylcholinesterase (AChE) and induces dyskinesia recovery by 74.5 and 88%, respectively, in a zebrafish model of Alzheimer’s disease when administered in tank water at a concentration of 50 μg/ml.{45219}  

     

    Brand:
    Cayman
    SKU:26900 - 50 mg

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  • Lincomycin is a lincosamide antibiotic first isolated from S. lincolnensis. It has a spectrum and mechanism of action similar to erythromycin (Item No. 16486), a macrolide antibiotic that inhibits bacterial protein synthesis and is effective against a host of bacterial genera, including Streptococcus, Staphylococcus, and Haemophilus (MIC90s range from 0.015-2.0 mg/l).{22680,22758} Lincomycin is closely related to clindamycin (Item No. 15006), a lincosamide antibiotic that is used for serious infections and in the prevention of emerging infections in burns.{22532,22529,22530,22528}  

     

    Brand:
    Cayman
    SKU:21526 -

    Out of stock

  • Lincomycin is a lincosamide antibiotic first isolated from S. lincolnensis. It has a spectrum and mechanism of action similar to erythromycin (Item No. 16486), a macrolide antibiotic that inhibits bacterial protein synthesis and is effective against a host of bacterial genera, including Streptococcus, Staphylococcus, and Haemophilus (MIC90s range from 0.015-2.0 mg/l).{22680,22758} Lincomycin is closely related to clindamycin (Item No. 15006), a lincosamide antibiotic that is used for serious infections and in the prevention of emerging infections in burns.{22532,22529,22530,22528}  

     

    Brand:
    Cayman
    SKU:21526 -

    Out of stock

  • Linderane is a sesquiterpene that has been found in L. aggregata.{45215,45216} It inhibits the cytochrome P450 (CYP) isoform CYP2C9 (Ki = 1.26 μM) in an irreversible and NADPH-dependent manner.{45215} Linderane decreases phosphoenolpyruvate carboxykinase (Pck1) and glucose-6-phosphatase (G6pc) gene expression, cAMP concentration, and CREB phosphorylation, increases phosphodiesterase 3 (PDE3) activity, and inhibits gluconeogenesis in rat primary hepatocytes.{45216} In vivo, linderane (50 mg/kg twice per day) decreases serum and hepatic triglyceride levels, as well as random-fed and fasting blood glucose levels in ob/ob mice.  

     

    Brand:
    Cayman
    SKU:27479 - 10 mg

    Available on backorder

  • Linderane is a sesquiterpene that has been found in L. aggregata.{45215,45216} It inhibits the cytochrome P450 (CYP) isoform CYP2C9 (Ki = 1.26 μM) in an irreversible and NADPH-dependent manner.{45215} Linderane decreases phosphoenolpyruvate carboxykinase (Pck1) and glucose-6-phosphatase (G6pc) gene expression, cAMP concentration, and CREB phosphorylation, increases phosphodiesterase 3 (PDE3) activity, and inhibits gluconeogenesis in rat primary hepatocytes.{45216} In vivo, linderane (50 mg/kg twice per day) decreases serum and hepatic triglyceride levels, as well as random-fed and fasting blood glucose levels in ob/ob mice.  

     

    Brand:
    Cayman
    SKU:27479 - 25 mg

    Available on backorder

  • Linderane is a sesquiterpene that has been found in L. aggregata.{45215,45216} It inhibits the cytochrome P450 (CYP) isoform CYP2C9 (Ki = 1.26 μM) in an irreversible and NADPH-dependent manner.{45215} Linderane decreases phosphoenolpyruvate carboxykinase (Pck1) and glucose-6-phosphatase (G6pc) gene expression, cAMP concentration, and CREB phosphorylation, increases phosphodiesterase 3 (PDE3) activity, and inhibits gluconeogenesis in rat primary hepatocytes.{45216} In vivo, linderane (50 mg/kg twice per day) decreases serum and hepatic triglyceride levels, as well as random-fed and fasting blood glucose levels in ob/ob mice.  

     

    Brand:
    Cayman
    SKU:27479 - 5 mg

    Available on backorder

  • Linderane is a sesquiterpene that has been found in L. aggregata.{45215,45216} It inhibits the cytochrome P450 (CYP) isoform CYP2C9 (Ki = 1.26 μM) in an irreversible and NADPH-dependent manner.{45215} Linderane decreases phosphoenolpyruvate carboxykinase (Pck1) and glucose-6-phosphatase (G6pc) gene expression, cAMP concentration, and CREB phosphorylation, increases phosphodiesterase 3 (PDE3) activity, and inhibits gluconeogenesis in rat primary hepatocytes.{45216} In vivo, linderane (50 mg/kg twice per day) decreases serum and hepatic triglyceride levels, as well as random-fed and fasting blood glucose levels in ob/ob mice.  

     

    Brand:
    Cayman
    SKU:27479 - 50 mg

    Available on backorder

  • Linezolid is a synthetic oxazolidinone antibiotic with activity against a wide range of Gram-positive bacteria, including resistant strains of several species, such as methicillin-resistant S. aureus (MRSA), penicillin-resistant pneumococci, vancomycin-resistant enterococci, various anaerobic bacteria, and several mycobacteria and streptococci (MICs = 2-4 mg/ml).{22653} Linezolid inhibits protein synthesis by binding to domain V of the 23S ribosomal RNA of the 50S subunit of bacterial ribosomes. In vivo, linezolid (50 mg/kg) reduces pulmonary MRSA load in spontaneously breathing and mechanically ventilated rabbits.{36681} Formulations containing linezolid have been used to treat MRSA infections.  

     

    Brand:
    Cayman
    SKU:-
  • Linezolid is a synthetic oxazolidinone antibiotic with activity against a wide range of Gram-positive bacteria, including resistant strains of several species, such as methicillin-resistant S. aureus (MRSA), penicillin-resistant pneumococci, vancomycin-resistant enterococci, various anaerobic bacteria, and several mycobacteria and streptococci (MICs = 2-4 mg/ml).{22653} Linezolid inhibits protein synthesis by binding to domain V of the 23S ribosomal RNA of the 50S subunit of bacterial ribosomes. In vivo, linezolid (50 mg/kg) reduces pulmonary MRSA load in spontaneously breathing and mechanically ventilated rabbits.{36681} Formulations containing linezolid have been used to treat MRSA infections.  

     

    Brand:
    Cayman
    SKU:-
  • Linezolid is a synthetic oxazolidinone antibiotic with activity against a wide range of Gram-positive bacteria, including resistant strains of several species, such as methicillin-resistant S. aureus (MRSA), penicillin-resistant pneumococci, vancomycin-resistant enterococci, various anaerobic bacteria, and several mycobacteria and streptococci (MICs = 2-4 mg/ml).{22653} Linezolid inhibits protein synthesis by binding to domain V of the 23S ribosomal RNA of the 50S subunit of bacterial ribosomes. In vivo, linezolid (50 mg/kg) reduces pulmonary MRSA load in spontaneously breathing and mechanically ventilated rabbits.{36681} Formulations containing linezolid have been used to treat MRSA infections.  

     

    Brand:
    Cayman
    SKU:-
  • Linezolid is a synthetic oxazolidinone antibiotic with activity against a wide range of Gram-positive bacteria, including resistant strains of several species, such as methicillin-resistant S. aureus (MRSA), penicillin-resistant pneumococci, vancomycin-resistant enterococci, various anaerobic bacteria, and several mycobacteria and streptococci (MICs = 2-4 mg/ml).{22653} Linezolid inhibits protein synthesis by binding to domain V of the 23S ribosomal RNA of the 50S subunit of bacterial ribosomes. In vivo, linezolid (50 mg/kg) reduces pulmonary MRSA load in spontaneously breathing and mechanically ventilated rabbits.{36681} Formulations containing linezolid have been used to treat MRSA infections.  

     

    Brand:
    Cayman
    SKU:-
  • Linezolid-d3 is intended for use as an internal standard for the quantification of linezolid (Item No. 15012) by GC- or LC-MS. Linezolid is a synthetic oxazolidinone antibiotic with activity against a wide range of Gram-positive bacteria, including resistant strains of several species, such as methicillin-resistant S. aureus (MRSA), penicillin-resistant pneumococci, vancomycin-resistant enterococci, various anaerobic bacteria, and several mycobacteria and streptococci (MICs = 2-4 mg/ml).{22653} Linezolid inhibits protein synthesis by binding to domain V of the 23S ribosomal RNA of the 50S subunit of bacterial ribosomes. In vivo, linezolid (50 mg/kg) reduces pulmonary MRSA load in spontaneously breathing and mechanically ventilated rabbits.{36681} Formulations containing linezolid have been used to treat MRSA infections.  

     

    Brand:
    Cayman
    SKU:25038 - 1 mg

    Available on backorder

  • Linezolid-d3 is intended for use as an internal standard for the quantification of linezolid (Item No. 15012) by GC- or LC-MS. Linezolid is a synthetic oxazolidinone antibiotic with activity against a wide range of Gram-positive bacteria, including resistant strains of several species, such as methicillin-resistant S. aureus (MRSA), penicillin-resistant pneumococci, vancomycin-resistant enterococci, various anaerobic bacteria, and several mycobacteria and streptococci (MICs = 2-4 mg/ml).{22653} Linezolid inhibits protein synthesis by binding to domain V of the 23S ribosomal RNA of the 50S subunit of bacterial ribosomes. In vivo, linezolid (50 mg/kg) reduces pulmonary MRSA load in spontaneously breathing and mechanically ventilated rabbits.{36681} Formulations containing linezolid have been used to treat MRSA infections.  

     

    Brand:
    Cayman
    SKU:25038 - 500 µg

    Available on backorder

  • Linoelaidic acid is the all-trans fatty acid homolog of linoleic acid. Trans-fatty acids are generally not detected in raw food oils, but constitute up to 25% of the unsaturated fat in partially hydrogenated oils.{5470}  

     

    Brand:
    Cayman
    SKU:90160 - 1 g

    Available on backorder

  • Linoelaidic acid is the all-trans fatty acid homolog of linoleic acid. Trans-fatty acids are generally not detected in raw food oils, but constitute up to 25% of the unsaturated fat in partially hydrogenated oils.{5470}  

     

    Brand:
    Cayman
    SKU:90160 - 100 mg

    Available on backorder

  • Linoelaidic acid is the all-trans fatty acid homolog of linoleic acid. Trans-fatty acids are generally not detected in raw food oils, but constitute up to 25% of the unsaturated fat in partially hydrogenated oils.{5470}  

     

    Brand:
    Cayman
    SKU:90160 - 250 mg

    Available on backorder

  • Linoelaidic acid is the all-trans fatty acid homolog of linoleic acid. Trans-fatty acids are generally not detected in raw food oils, but constitute up to 25% of the unsaturated fat in partially hydrogenated oils.{5470}  

     

    Brand:
    Cayman
    SKU:90160 - 5 g

    Available on backorder

  • Linoelaidic acid methyl ester is an esterified form of linoelaidic acid (Item No. 90160). It has been found in H. sabdariffa essential oil as well as biodiesel produced from sea mango seed oil.{49143,49144}  

     

    Brand:
    Cayman
    SKU:26732 - 100 mg

    Available on backorder

  • Linoelaidic acid methyl ester is an esterified form of linoelaidic acid (Item No. 90160). It has been found in H. sabdariffa essential oil as well as biodiesel produced from sea mango seed oil.{49143,49144}  

     

    Brand:
    Cayman
    SKU:26732 - 50 mg

    Available on backorder

  • Linoleic acid is an essential ω-6 polyunsaturated fatty acid (PUFA).{52085} It is the most abundant PUFA in a variety of foods, and dietary sources of linoleic acid include vegetable oils, meats, nuts, seeds, and eggs. Linoleic acid (30 μM) increases migration of IEC-6 rat intestinal epithelial cells in a wound healing assay.{56127} Rats fed a linoleate-deficient diet exhibit decreased body weight and an increased ratio of eicosatrienoate to arachidonate in liver and serum phospholipids compared with rats fed a control diet, as well as mild scaling of forepaw skin.{56128}  

     

    Brand:
    Cayman
    SKU:90150 - 1 g

    Available on backorder

  • Linoleic acid is an essential ω-6 polyunsaturated fatty acid (PUFA).{52085} It is the most abundant PUFA in a variety of foods, and dietary sources of linoleic acid include vegetable oils, meats, nuts, seeds, and eggs. Linoleic acid (30 μM) increases migration of IEC-6 rat intestinal epithelial cells in a wound healing assay.{56127} Rats fed a linoleate-deficient diet exhibit decreased body weight and an increased ratio of eicosatrienoate to arachidonate in liver and serum phospholipids compared with rats fed a control diet, as well as mild scaling of forepaw skin.{56128}  

     

    Brand:
    Cayman
    SKU:90150 - 100 mg

    Available on backorder

  • Linoleic acid is an essential ω-6 polyunsaturated fatty acid (PUFA).{52085} It is the most abundant PUFA in a variety of foods, and dietary sources of linoleic acid include vegetable oils, meats, nuts, seeds, and eggs. Linoleic acid (30 μM) increases migration of IEC-6 rat intestinal epithelial cells in a wound healing assay.{56127} Rats fed a linoleate-deficient diet exhibit decreased body weight and an increased ratio of eicosatrienoate to arachidonate in liver and serum phospholipids compared with rats fed a control diet, as well as mild scaling of forepaw skin.{56128}  

     

    Brand:
    Cayman
    SKU:90150 - 50 mg

    Available on backorder

  • Linoleic acid is an essential ω-6 polyunsaturated fatty acid (PUFA).{52085} It is the most abundant PUFA in a variety of foods, and dietary sources of linoleic acid include vegetable oils, meats, nuts, seeds, and eggs. Linoleic acid (30 μM) increases migration of IEC-6 rat intestinal epithelial cells in a wound healing assay.{56127} Rats fed a linoleate-deficient diet exhibit decreased body weight and an increased ratio of eicosatrienoate to arachidonate in liver and serum phospholipids compared with rats fed a control diet, as well as mild scaling of forepaw skin.{56128}  

     

    Brand:
    Cayman
    SKU:90150 - 500 mg

    Available on backorder

  • Linoleic acid is an essential ω-6 polyunsaturated fatty acid (PUFA).{52085} It is the most abundant PUFA in a variety of foods, and dietary sources of linoleic acid include vegetable oils, meats, nuts, seeds, and eggs. Linoleic acid (30 μM) increases migration of IEC-6 rat intestinal epithelial cells in a wound healing assay.{56127} Rats fed a linoleate-deficient diet exhibit decreased body weight and an increased ratio of eicosatrienoate to arachidonate in liver and serum phospholipids compared with rats fed a control diet, as well as mild scaling of forepaw skin.{56128} Linoleic acid (peroxide free) contains the antioxidant BHT (Item No. 89910). BHT-free linoleic acid (Item Nos. 90150 | 21909) is also available.  

     

    Brand:
    Cayman
    SKU:90150.1 - 100 mg

    Available on backorder

  • Linoleic acid is an essential ω-6 polyunsaturated fatty acid (PUFA).{52085} It is the most abundant PUFA in a variety of foods, and dietary sources of linoleic acid include vegetable oils, meats, nuts, seeds, and eggs. Linoleic acid (30 μM) increases migration of IEC-6 rat intestinal epithelial cells in a wound healing assay.{56127} Rats fed a linoleate-deficient diet exhibit decreased body weight and an increased ratio of eicosatrienoate to arachidonate in liver and serum phospholipids compared with rats fed a control diet, as well as mild scaling of forepaw skin.{56128} Linoleic acid (peroxide free) contains the antioxidant BHT (Item No. 89910). BHT-free linoleic acid (Item Nos. 90150 | 21909) is also available.  

     

    Brand:
    Cayman
    SKU:90150.1 - 250 mg

    Available on backorder

  • Linoleic acid is an essential ω-6 polyunsaturated fatty acid (PUFA).{52085} It is the most abundant PUFA in a variety of foods, and dietary sources of linoleic acid include vegetable oils, meats, nuts, seeds, and eggs. Linoleic acid (30 μM) increases migration of IEC-6 rat intestinal epithelial cells in a wound healing assay.{56127} Rats fed a linoleate-deficient diet exhibit decreased body weight and an increased ratio of eicosatrienoate to arachidonate in liver and serum phospholipids compared with rats fed a control diet, as well as mild scaling of forepaw skin.{56128} Linoleic acid (peroxide free) contains the antioxidant BHT (Item No. 89910). BHT-free linoleic acid (Item Nos. 90150 | 21909) is also available.  

     

    Brand:
    Cayman
    SKU:90150.1 - 50 mg

    Available on backorder

  • Linoleic acid is an essential ω-6 polyunsaturated fatty acid (PUFA).{52085} It is the most abundant PUFA in a variety of foods, and dietary sources of linoleic acid include vegetable oils, meats, nuts, seeds, and eggs. Linoleic acid (30 μM) increases migration of IEC-6 rat intestinal epithelial cells in a wound healing assay.{56127} Rats fed a linoleate-deficient diet exhibit decreased body weight and an increased ratio of eicosatrienoate to arachidonate in liver and serum phospholipids compared with rats fed a control diet, as well as mild scaling of forepaw skin.{56128} Linoleic acid (peroxide free) contains the antioxidant BHT (Item No. 89910). BHT-free linoleic acid (Item Nos. 90150 | 21909) is also available.  

     

    Brand:
    Cayman
    SKU:90150.1 - 500 mg

    Available on backorder

  • Linoleic acid is an essential ω-6 polyunsaturated fatty acid (PUFA).{52085} It is the most abundant PUFA in a variety of foods, and dietary sources of linoleic acid include vegetable oils, meats, nuts, seeds, and eggs. Linoleic acid (30 μM) increases migration of IEC-6 rat intestinal epithelial cells in a wound healing assay.{56127} Rats fed a linoleate-deficient diet exhibit decreased body weight and an increased ratio of eicosatrienoate to arachidonate in liver and serum phospholipids compared with rats fed a control diet, as well as mild scaling of forepaw skin.{56128}  

     

    Brand:
    Cayman
    SKU:21909 -

    Out of stock

  • Linoleic acid is an essential ω-6 polyunsaturated fatty acid (PUFA).{52085} It is the most abundant PUFA in a variety of foods, and dietary sources of linoleic acid include vegetable oils, meats, nuts, seeds, and eggs. Linoleic acid (30 μM) increases migration of IEC-6 rat intestinal epithelial cells in a wound healing assay.{56127} Rats fed a linoleate-deficient diet exhibit decreased body weight and an increased ratio of eicosatrienoate to arachidonate in liver and serum phospholipids compared with rats fed a control diet, as well as mild scaling of forepaw skin.{56128}  

     

    Brand:
    Cayman
    SKU:21909 -

    Out of stock

  • Linoleic acid is an essential ω-6 polyunsaturated fatty acid (PUFA).{52085} It is the most abundant PUFA in a variety of foods, and dietary sources of linoleic acid include vegetable oils, meats, nuts, seeds, and eggs. Linoleic acid (30 μM) increases migration of IEC-6 rat intestinal epithelial cells in a wound healing assay.{56127} Rats fed a linoleate-deficient diet exhibit decreased body weight and an increased ratio of eicosatrienoate to arachidonate in liver and serum phospholipids compared with rats fed a control diet, as well as mild scaling of forepaw skin.{56128}  

     

    Brand:
    Cayman
    SKU:21909 -

    Out of stock

  • Linoleic acid alkyne is an ω-alkyne derivative of linoleic acid (Item No. 90150). The ω-alkyne moiety allows Cu(I)-catalyzed cycloaddition chemistry with other molecules containing an azide group.{33415,33416} Linoleic acid alkyne has been used in experiments focusing on the biological roles of linoleic acid.{26526,33418} Alternatively, this modified lipid can be used to synthesize other alkyne-containing products, such as glycerophospholipids, for click chemistry.{33417}  

     

    Brand:
    Cayman
    SKU:10541 - 1 mg

    Available on backorder

  • Linoleic acid alkyne is an ω-alkyne derivative of linoleic acid (Item No. 90150). The ω-alkyne moiety allows Cu(I)-catalyzed cycloaddition chemistry with other molecules containing an azide group.{33415,33416} Linoleic acid alkyne has been used in experiments focusing on the biological roles of linoleic acid.{26526,33418} Alternatively, this modified lipid can be used to synthesize other alkyne-containing products, such as glycerophospholipids, for click chemistry.{33417}  

     

    Brand:
    Cayman
    SKU:10541 - 100 µg

    Available on backorder

  • Linoleic acid alkyne is an ω-alkyne derivative of linoleic acid (Item No. 90150). The ω-alkyne moiety allows Cu(I)-catalyzed cycloaddition chemistry with other molecules containing an azide group.{33415,33416} Linoleic acid alkyne has been used in experiments focusing on the biological roles of linoleic acid.{26526,33418} Alternatively, this modified lipid can be used to synthesize other alkyne-containing products, such as glycerophospholipids, for click chemistry.{33417}  

     

    Brand:
    Cayman
    SKU:10541 - 5 mg

    Available on backorder

  • Linoleic acid alkyne is an ω-alkyne derivative of linoleic acid (Item No. 90150). The ω-alkyne moiety allows Cu(I)-catalyzed cycloaddition chemistry with other molecules containing an azide group.{33415,33416} Linoleic acid alkyne has been used in experiments focusing on the biological roles of linoleic acid.{26526,33418} Alternatively, this modified lipid can be used to synthesize other alkyne-containing products, such as glycerophospholipids, for click chemistry.{33417}  

     

    Brand:
    Cayman
    SKU:10541 - 500 µg

    Available on backorder

  • Linoleic acid ethyl ester is an esterified form of linoleic acid (Item Nos. 90150 | 90150.1 | 21909). It is active against the bacteria S. mutans, A. actinomycetemcomitans, P. gingivalis, S. gordonii, and S. sanguis and the fungus C. albicans when used at a concentration of 25 µg/ml.{53851} Linoleic acid ethyl ester (5 and 10 µM) inhibits LPS-induced production of nitric oxide (NO), prostaglandin E2 (PGE2; Item No. 14010), IL-6, and TNF-α in RAW 264.7 cells.{53852} Formulations containing linoleic acid ethyl ester have been used in cosmetics for the treatment of acne.  

     

    Brand:
    Cayman
    SKU:10008198 - 1 g

    Available on backorder

  • Linoleic acid ethyl ester is an esterified form of linoleic acid (Item Nos. 90150 | 90150.1 | 21909). It is active against the bacteria S. mutans, A. actinomycetemcomitans, P. gingivalis, S. gordonii, and S. sanguis and the fungus C. albicans when used at a concentration of 25 µg/ml.{53851} Linoleic acid ethyl ester (5 and 10 µM) inhibits LPS-induced production of nitric oxide (NO), prostaglandin E2 (PGE2; Item No. 14010), IL-6, and TNF-α in RAW 264.7 cells.{53852} Formulations containing linoleic acid ethyl ester have been used in cosmetics for the treatment of acne.  

     

    Brand:
    Cayman
    SKU:10008198 - 100 mg

    Available on backorder

  • Linoleic acid ethyl ester is an esterified form of linoleic acid (Item Nos. 90150 | 90150.1 | 21909). It is active against the bacteria S. mutans, A. actinomycetemcomitans, P. gingivalis, S. gordonii, and S. sanguis and the fungus C. albicans when used at a concentration of 25 µg/ml.{53851} Linoleic acid ethyl ester (5 and 10 µM) inhibits LPS-induced production of nitric oxide (NO), prostaglandin E2 (PGE2; Item No. 14010), IL-6, and TNF-α in RAW 264.7 cells.{53852} Formulations containing linoleic acid ethyl ester have been used in cosmetics for the treatment of acne.  

     

    Brand:
    Cayman
    SKU:10008198 - 50 mg

    Available on backorder

  • Linoleic acid ethyl ester is an esterified form of linoleic acid (Item Nos. 90150 | 90150.1 | 21909). It is active against the bacteria S. mutans, A. actinomycetemcomitans, P. gingivalis, S. gordonii, and S. sanguis and the fungus C. albicans when used at a concentration of 25 µg/ml.{53851} Linoleic acid ethyl ester (5 and 10 µM) inhibits LPS-induced production of nitric oxide (NO), prostaglandin E2 (PGE2; Item No. 14010), IL-6, and TNF-α in RAW 264.7 cells.{53852} Formulations containing linoleic acid ethyl ester have been used in cosmetics for the treatment of acne.  

     

    Brand:
    Cayman
    SKU:10008198 - 500 mg

    Available on backorder

  • Linoleic acid methyl ester is an esterified form of linoleic acid (Item Nos. 90150 | 90150.1 | 21909). It has been found in several types of animal fat biodiesel and biodiesel synthesized from beef tallow, soybean oil, and babassu oil blends.{48244,48265} It has been used as a substrate to measure the antioxidant activity of β-carotene (Item No. 16837) against free radical-induced lipid peroxidation.{56142}  

     

    Brand:
    Cayman
    SKU:20603 -

    Available on backorder

  • Linoleic acid methyl ester is an esterified form of linoleic acid (Item Nos. 90150 | 90150.1 | 21909). It has been found in several types of animal fat biodiesel and biodiesel synthesized from beef tallow, soybean oil, and babassu oil blends.{48244,48265} It has been used as a substrate to measure the antioxidant activity of β-carotene (Item No. 16837) against free radical-induced lipid peroxidation.{56142}  

     

    Brand:
    Cayman
    SKU:20603 -

    Available on backorder

  • Linoleic acid methyl ester is an esterified form of linoleic acid (Item Nos. 90150 | 90150.1 | 21909). It has been found in several types of animal fat biodiesel and biodiesel synthesized from beef tallow, soybean oil, and babassu oil blends.{48244,48265} It has been used as a substrate to measure the antioxidant activity of β-carotene (Item No. 16837) against free radical-induced lipid peroxidation.{56142}  

     

    Brand:
    Cayman
    SKU:20603 -

    Available on backorder

  • Linoleic Acid-13C18 is intended for use as an internal standard for the quantification of linoleic acid (Item Nos. 90150 | 90150.1 | 21909) by GC- or LC-MS. Linoleic acid is an essential ω-6 polyunsaturated fatty acid (PUFA).{52085} It is the most abundant PUFA in a variety of foods, and dietary sources of linoleic acid include vegetable oils, meats, nuts, seeds, and eggs. Linoleic acid (30 μM) increases migration of IEC-6 rat intestinal epithelial cells in a wound healing assay.{56127} Rats fed a linoleate-deficient diet exhibit decreased body weight and an increased ratio of eicosatrienoate to arachidonate in liver and serum phospholipids compared with rats fed a control diet, as well as mild scaling of forepaw skin.{56128}  

     

    Brand:
    Cayman
    SKU:31159 - 1 mg

    Available on backorder

  • Linoleic Acid-13C18 is intended for use as an internal standard for the quantification of linoleic acid (Item Nos. 90150 | 90150.1 | 21909) by GC- or LC-MS. Linoleic acid is an essential ω-6 polyunsaturated fatty acid (PUFA).{52085} It is the most abundant PUFA in a variety of foods, and dietary sources of linoleic acid include vegetable oils, meats, nuts, seeds, and eggs. Linoleic acid (30 μM) increases migration of IEC-6 rat intestinal epithelial cells in a wound healing assay.{56127} Rats fed a linoleate-deficient diet exhibit decreased body weight and an increased ratio of eicosatrienoate to arachidonate in liver and serum phospholipids compared with rats fed a control diet, as well as mild scaling of forepaw skin.{56128}  

     

    Brand:
    Cayman
    SKU:31159 - 100 µg

    Available on backorder

  • Linoleic acid-13C18 ethyl ester is intended for use as an internal standard for the quantification of linoleic acid ethyl ester (Item No. 10008198) by GC- or LC-MS. Linoleic acid ethyl ester is an esterified form of linoleic acid (Item Nos. 90150 | 90150.1 | 21909). Linoleic acid is an essential fatty acid and one of the most abundant polyunsaturated fatty acids in the Western diet.{52085} Deficiencies in linoleic acid are linked to defective wound healing, growth retardation, and dermatitis.{1017,2418} Linoleic acid is metabolized in both plants and animals to form 9(S)- and 13(S)-HODE.{770}  

     

    Brand:
    Cayman
    SKU:28750 - 1 mg

    Available on backorder

  • Linoleic acid-13C18 ethyl ester is intended for use as an internal standard for the quantification of linoleic acid ethyl ester (Item No. 10008198) by GC- or LC-MS. Linoleic acid ethyl ester is an esterified form of linoleic acid (Item Nos. 90150 | 90150.1 | 21909). Linoleic acid is an essential fatty acid and one of the most abundant polyunsaturated fatty acids in the Western diet.{52085} Deficiencies in linoleic acid are linked to defective wound healing, growth retardation, and dermatitis.{1017,2418} Linoleic acid is metabolized in both plants and animals to form 9(S)- and 13(S)-HODE.{770}  

     

    Brand:
    Cayman
    SKU:28750 - 100 µg

    Available on backorder

  • Linoleic acid-13C18 ethyl ester is intended for use as an internal standard for the quantification of linoleic acid ethyl ester (Item No. 10008198) by GC- or LC-MS. Linoleic acid ethyl ester is an esterified form of linoleic acid (Item Nos. 90150 | 90150.1 | 21909). Linoleic acid is an essential fatty acid and one of the most abundant polyunsaturated fatty acids in the Western diet.{52085} Deficiencies in linoleic acid are linked to defective wound healing, growth retardation, and dermatitis.{1017,2418} Linoleic acid is metabolized in both plants and animals to form 9(S)- and 13(S)-HODE.{770}  

     

    Brand:
    Cayman
    SKU:28750 - 500 µg

    Available on backorder

  • Linoleic acid-d4 is intended for use as an internal standard for the quantification of linoleic acid (Item Nos. 90150 | 90150.1 | 21909) by GC- or LC-MS. Linoleic acid is an essential ω-6 polyunsaturated fatty acid (PUFA).{52085} It is the most abundant PUFA in a variety of foods, and dietary sources of linoleic acid include vegetable oils, meats, nuts, seeds, and eggs. Linoleic acid (30 μM) increases migration of IEC-6 rat intestinal epithelial cells in a wound healing assay.{56127} Rats fed a linoleate-deficient diet exhibit decreased body weight and an increased ratio of eicosatrienoate to arachidonate in liver and serum phospholipids compared with rats fed a control diet, as well as mild scaling of forepaw skin.{56128}  

     

    Brand:
    Cayman
    SKU:390150 - 1 mg

    Available on backorder

  • Linoleic acid-d4 is intended for use as an internal standard for the quantification of linoleic acid (Item Nos. 90150 | 90150.1 | 21909) by GC- or LC-MS. Linoleic acid is an essential ω-6 polyunsaturated fatty acid (PUFA).{52085} It is the most abundant PUFA in a variety of foods, and dietary sources of linoleic acid include vegetable oils, meats, nuts, seeds, and eggs. Linoleic acid (30 μM) increases migration of IEC-6 rat intestinal epithelial cells in a wound healing assay.{56127} Rats fed a linoleate-deficient diet exhibit decreased body weight and an increased ratio of eicosatrienoate to arachidonate in liver and serum phospholipids compared with rats fed a control diet, as well as mild scaling of forepaw skin.{56128}  

     

    Brand:
    Cayman
    SKU:390150 - 5 mg

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  • Linoleic acid-d4 is intended for use as an internal standard for the quantification of linoleic acid (Item Nos. 90150 | 90150.1 | 21909) by GC- or LC-MS. Linoleic acid is an essential ω-6 polyunsaturated fatty acid (PUFA).{52085} It is the most abundant PUFA in a variety of foods, and dietary sources of linoleic acid include vegetable oils, meats, nuts, seeds, and eggs. Linoleic acid (30 μM) increases migration of IEC-6 rat intestinal epithelial cells in a wound healing assay.{56127} Rats fed a linoleate-deficient diet exhibit decreased body weight and an increased ratio of eicosatrienoate to arachidonate in liver and serum phospholipids compared with rats fed a control diet, as well as mild scaling of forepaw skin.{56128}  

     

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    Cayman
    SKU:390150 - 500 µg

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  • Linoleoyl ethanolamide is an endocannabinoid detected in porcine brain and murine peritoneal macrophages which contains linoleate in place of the arachidonate moiety of arachidonyl ethanolamide (AEA).{11172,11151} It has weak affinity for the cannabinoid 1 (CB1) and CB2 receptors, exhibiting Ki values of 10 µM and 25 µM, respectively.{7422} However, it is only approximately 4-fold less potent than AEA at causing catalepsy in mice (ED50 of 26.5 mg/kg).{11177} In addition, linoleoyl ethanolamide increases ERK phosphorylation and AP-1-dependent transcription approximately 1.5 fold at 15 µM in a CB-receptor-independent manner.{11152} However, cellular toxicity is readily apparent at concentrations of 10-20 µM. Linoleoyl ethanolamide inhibits human fatty acid amide hydrolase-dependent hydrolysis of AEA with a Ki value of 9.0 µM, but also is hydrolyzed effectively by the enzyme.{7251,3922}  

     

    Brand:
    Cayman
    SKU:90155 - 10 mg

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  • Linoleoyl ethanolamide is an endocannabinoid detected in porcine brain and murine peritoneal macrophages which contains linoleate in place of the arachidonate moiety of arachidonyl ethanolamide (AEA).{11172,11151} It has weak affinity for the cannabinoid 1 (CB1) and CB2 receptors, exhibiting Ki values of 10 µM and 25 µM, respectively.{7422} However, it is only approximately 4-fold less potent than AEA at causing catalepsy in mice (ED50 of 26.5 mg/kg).{11177} In addition, linoleoyl ethanolamide increases ERK phosphorylation and AP-1-dependent transcription approximately 1.5 fold at 15 µM in a CB-receptor-independent manner.{11152} However, cellular toxicity is readily apparent at concentrations of 10-20 µM. Linoleoyl ethanolamide inhibits human fatty acid amide hydrolase-dependent hydrolysis of AEA with a Ki value of 9.0 µM, but also is hydrolyzed effectively by the enzyme.{7251,3922}  

     

    Brand:
    Cayman
    SKU:90155 - 100 mg

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  • Linoleoyl ethanolamide is an endocannabinoid detected in porcine brain and murine peritoneal macrophages which contains linoleate in place of the arachidonate moiety of arachidonyl ethanolamide (AEA).{11172,11151} It has weak affinity for the cannabinoid 1 (CB1) and CB2 receptors, exhibiting Ki values of 10 µM and 25 µM, respectively.{7422} However, it is only approximately 4-fold less potent than AEA at causing catalepsy in mice (ED50 of 26.5 mg/kg).{11177} In addition, linoleoyl ethanolamide increases ERK phosphorylation and AP-1-dependent transcription approximately 1.5 fold at 15 µM in a CB-receptor-independent manner.{11152} However, cellular toxicity is readily apparent at concentrations of 10-20 µM. Linoleoyl ethanolamide inhibits human fatty acid amide hydrolase-dependent hydrolysis of AEA with a Ki value of 9.0 µM, but also is hydrolyzed effectively by the enzyme.{7251,3922}  

     

    Brand:
    Cayman
    SKU:90155 - 5 mg

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  • Linoleoyl ethanolamide is an endocannabinoid detected in porcine brain and murine peritoneal macrophages which contains linoleate in place of the arachidonate moiety of arachidonyl ethanolamide (AEA).{11172,11151} It has weak affinity for the cannabinoid 1 (CB1) and CB2 receptors, exhibiting Ki values of 10 µM and 25 µM, respectively.{7422} However, it is only approximately 4-fold less potent than AEA at causing catalepsy in mice (ED50 of 26.5 mg/kg).{11177} In addition, linoleoyl ethanolamide increases ERK phosphorylation and AP-1-dependent transcription approximately 1.5 fold at 15 µM in a CB-receptor-independent manner.{11152} However, cellular toxicity is readily apparent at concentrations of 10-20 µM. Linoleoyl ethanolamide inhibits human fatty acid amide hydrolase-dependent hydrolysis of AEA with a Ki value of 9.0 µM, but also is hydrolyzed effectively by the enzyme.{7251,3922}  

     

    Brand:
    Cayman
    SKU:90155 - 50 mg

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  • Linoleoyl ethanolamide phosphate is an intermediate in the biosynthesis of linoleoyl ethanolamide (Item No. 90155) that can be generated through phospholipase C-mediated hydrolysis of N-acylphosphatidylethanolamine.{24249} Linoleoyl ethanolamide phosphate, along with other endogenous N-acylethanolamines, is thought to play a role in the regulation of food intake by selective prolongation of feeding latency and post-meal interval.{24250}  

     

    Brand:
    Cayman
    SKU:9001837 - 1 mg

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  • Linoleoyl ethanolamide phosphate is an intermediate in the biosynthesis of linoleoyl ethanolamide (Item No. 90155) that can be generated through phospholipase C-mediated hydrolysis of N-acylphosphatidylethanolamine.{24249} Linoleoyl ethanolamide phosphate, along with other endogenous N-acylethanolamines, is thought to play a role in the regulation of food intake by selective prolongation of feeding latency and post-meal interval.{24250}  

     

    Brand:
    Cayman
    SKU:9001837 - 5 mg

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  • Linoleoyl ethanolamide phosphate is an intermediate in the biosynthesis of linoleoyl ethanolamide (Item No. 90155) that can be generated through phospholipase C-mediated hydrolysis of N-acylphosphatidylethanolamine.{24249} Linoleoyl ethanolamide phosphate, along with other endogenous N-acylethanolamines, is thought to play a role in the regulation of food intake by selective prolongation of feeding latency and post-meal interval.{24250}  

     

    Brand:
    Cayman
    SKU:9001837 - 500 µg

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  • Linoleoyl ethanolamide-d4 contains four deuterium atoms at the hydroxyethyl 1,1′,2, and 2′ positions. It is intended for use as an internal standard for the quantification of linoleoyl ethanolamide (Item No. 90155) by GC- or LC-mass spectrometry. Linoleoyl ethanolamide is an endocannabinoid detected in porcine brain and murine peritoneal macrophages which contains linoleate in place of the arachidonate moiety of arachidonoyl ethanolamide (AEA).{11172,11151} It has weak affinity for the central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors, exhibiting Ki values of 10 µM and 25 µM, respectively.{7422} However, it is only approximately 4-fold less potent than AEA at causing catalepsy in mice (ED50 of 26.5 mg/kg).{11177} In addition, linoleoyl ethanolamide increases ERK phosphorylation and AP-1-dependent transcription approximately 1.5-fold at 15 µM in a CB-receptor-independent manner.{11152} However, cellular toxicity is readily apparent at concentrations of 10-20 µM. Linoleoyl ethanolamide inhibits human fatty acid amide hydrolase-dependent hydrolysis of AEA with a Ki value of 9.0 µM, but also is hydrolyzed effectively by the enzyme.{7251,3922}  

     

    Brand:
    Cayman
    SKU:9000553 - 1 mg

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  • Linoleoyl ethanolamide-d4 contains four deuterium atoms at the hydroxyethyl 1,1′,2, and 2′ positions. It is intended for use as an internal standard for the quantification of linoleoyl ethanolamide (Item No. 90155) by GC- or LC-mass spectrometry. Linoleoyl ethanolamide is an endocannabinoid detected in porcine brain and murine peritoneal macrophages which contains linoleate in place of the arachidonate moiety of arachidonoyl ethanolamide (AEA).{11172,11151} It has weak affinity for the central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors, exhibiting Ki values of 10 µM and 25 µM, respectively.{7422} However, it is only approximately 4-fold less potent than AEA at causing catalepsy in mice (ED50 of 26.5 mg/kg).{11177} In addition, linoleoyl ethanolamide increases ERK phosphorylation and AP-1-dependent transcription approximately 1.5-fold at 15 µM in a CB-receptor-independent manner.{11152} However, cellular toxicity is readily apparent at concentrations of 10-20 µM. Linoleoyl ethanolamide inhibits human fatty acid amide hydrolase-dependent hydrolysis of AEA with a Ki value of 9.0 µM, but also is hydrolyzed effectively by the enzyme.{7251,3922}  

     

    Brand:
    Cayman
    SKU:9000553 - 100 µg

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  • Linoleoyl ethanolamide-d4 contains four deuterium atoms at the hydroxyethyl 1,1′,2, and 2′ positions. It is intended for use as an internal standard for the quantification of linoleoyl ethanolamide (Item No. 90155) by GC- or LC-mass spectrometry. Linoleoyl ethanolamide is an endocannabinoid detected in porcine brain and murine peritoneal macrophages which contains linoleate in place of the arachidonate moiety of arachidonoyl ethanolamide (AEA).{11172,11151} It has weak affinity for the central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors, exhibiting Ki values of 10 µM and 25 µM, respectively.{7422} However, it is only approximately 4-fold less potent than AEA at causing catalepsy in mice (ED50 of 26.5 mg/kg).{11177} In addition, linoleoyl ethanolamide increases ERK phosphorylation and AP-1-dependent transcription approximately 1.5-fold at 15 µM in a CB-receptor-independent manner.{11152} However, cellular toxicity is readily apparent at concentrations of 10-20 µM. Linoleoyl ethanolamide inhibits human fatty acid amide hydrolase-dependent hydrolysis of AEA with a Ki value of 9.0 µM, but also is hydrolyzed effectively by the enzyme.{7251,3922}  

     

    Brand:
    Cayman
    SKU:9000553 - 5 mg

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  • Linoleoyl ethanolamide-d4 contains four deuterium atoms at the hydroxyethyl 1,1′,2, and 2′ positions. It is intended for use as an internal standard for the quantification of linoleoyl ethanolamide (Item No. 90155) by GC- or LC-mass spectrometry. Linoleoyl ethanolamide is an endocannabinoid detected in porcine brain and murine peritoneal macrophages which contains linoleate in place of the arachidonate moiety of arachidonoyl ethanolamide (AEA).{11172,11151} It has weak affinity for the central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors, exhibiting Ki values of 10 µM and 25 µM, respectively.{7422} However, it is only approximately 4-fold less potent than AEA at causing catalepsy in mice (ED50 of 26.5 mg/kg).{11177} In addition, linoleoyl ethanolamide increases ERK phosphorylation and AP-1-dependent transcription approximately 1.5-fold at 15 µM in a CB-receptor-independent manner.{11152} However, cellular toxicity is readily apparent at concentrations of 10-20 µM. Linoleoyl ethanolamide inhibits human fatty acid amide hydrolase-dependent hydrolysis of AEA with a Ki value of 9.0 µM, but also is hydrolyzed effectively by the enzyme.{7251,3922}  

     

    Brand:
    Cayman
    SKU:9000553 - 500 µg

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  • N-Linoleoyl phenylalanine is an endogenous N-acyl amine found in D. melanogaster larvae.{33755} N-acyl amines have been shown to have anti-inflammatory action that can be monitored using 15-deoxy-prostaglandin J2 (PGJ2) quantification.{29259},{34731} N-Linoleoyl phenylalanine does not increase PGJ2 expression in RAW cells, indicating lack of an anti-inflammatory action.{34731} N-acyl amines also promote mitochondrial uncoupling.{31656}  

     

    Brand:
    Cayman
    SKU:20063 -

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  • N-Linoleoyl phenylalanine is an endogenous N-acyl amine found in D. melanogaster larvae.{33755} N-acyl amines have been shown to have anti-inflammatory action that can be monitored using 15-deoxy-prostaglandin J2 (PGJ2) quantification.{29259},{34731} N-Linoleoyl phenylalanine does not increase PGJ2 expression in RAW cells, indicating lack of an anti-inflammatory action.{34731} N-acyl amines also promote mitochondrial uncoupling.{31656}  

     

    Brand:
    Cayman
    SKU:20063 -

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  • N-Linoleoyl phenylalanine is an endogenous N-acyl amine found in D. melanogaster larvae.{33755} N-acyl amines have been shown to have anti-inflammatory action that can be monitored using 15-deoxy-prostaglandin J2 (PGJ2) quantification.{29259},{34731} N-Linoleoyl phenylalanine does not increase PGJ2 expression in RAW cells, indicating lack of an anti-inflammatory action.{34731} N-acyl amines also promote mitochondrial uncoupling.{31656}  

     

    Brand:
    Cayman
    SKU:20063 -

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  • N-Linoleoyl phenylalanine is an endogenous N-acyl amine found in D. melanogaster larvae.{33755} N-acyl amines have been shown to have anti-inflammatory action that can be monitored using 15-deoxy-prostaglandin J2 (PGJ2) quantification.{29259},{34731} N-Linoleoyl phenylalanine does not increase PGJ2 expression in RAW cells, indicating lack of an anti-inflammatory action.{34731} N-acyl amines also promote mitochondrial uncoupling.{31656}  

     

    Brand:
    Cayman
    SKU:20063 -

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  • Linoleoyl-L-carnitine is a naturally occurring long-chain acylcarnitine.{43657} Hepatic levels of linoleoyl-L-carnitine are increased following high-dose (200 mg/kg) administration of isoniazid (Item No. 20378) in mice.  

     

    Brand:
    Cayman
    SKU:26560 - 1 mg

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  • Linoleoyl-L-carnitine is a naturally occurring long-chain acylcarnitine.{43657} Hepatic levels of linoleoyl-L-carnitine are increased following high-dose (200 mg/kg) administration of isoniazid (Item No. 20378) in mice.  

     

    Brand:
    Cayman
    SKU:26560 - 10 mg

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  • Linoleoyl-L-carnitine is a naturally occurring long-chain acylcarnitine.{43657} Hepatic levels of linoleoyl-L-carnitine are increased following high-dose (200 mg/kg) administration of isoniazid (Item No. 20378) in mice.  

     

    Brand:
    Cayman
    SKU:26560 - 5 mg

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  • Linoleoyl-L-carnitine is a naturally occurring long-chain acylcarnitine.{43657} Hepatic levels of linoleoyl-L-carnitine are increased following high-dose (200 mg/kg) administration of isoniazid (Item No. 20378) in mice.  

     

    Brand:
    Cayman
    SKU:26560 - 500 µg

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  • Linopirdine is an enhancer of the stimulus-evoked but not basal release of several neurotransmitters, including acetylcholine, dopamine, serotonin, and glutamate. It increases acetylcholine release in rat hippocampal CA1 neurons by blocking voltage-gated, calcium-activated and leak (M-type; Kv7.2/7.3; KCNQ2/3) K+ current with an IC50 value of 2.4 µM.{31443,31441} Inhibition of M-channels is reported to result in the depolarization of CA3 pyramidal neurons and activated presynaptic voltage-gated P/Q- and N-type calcium channels, which leads to Ca2+ influx and increased neurotransmitter release.{31444} Linopirdine has been shown to produce a number of effects including EEG patterns of enhanced vigilance, induction of c-fos expression in cerebral cortex, reduction of the increase of cerebral glucose utilization induced by hypoxia, and improved performance in animal models of learning and memory.{31445} Linopirdine has also been identified as an agonist of transient receptor potential vanilloid type 1 (EC50 = 115 µM in HEK293 cells voltage clamped at -60 mV).{31442}  

     

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    Cayman
    SKU:-

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  • Linopirdine is an enhancer of the stimulus-evoked but not basal release of several neurotransmitters, including acetylcholine, dopamine, serotonin, and glutamate. It increases acetylcholine release in rat hippocampal CA1 neurons by blocking voltage-gated, calcium-activated and leak (M-type; Kv7.2/7.3; KCNQ2/3) K+ current with an IC50 value of 2.4 µM.{31443,31441} Inhibition of M-channels is reported to result in the depolarization of CA3 pyramidal neurons and activated presynaptic voltage-gated P/Q- and N-type calcium channels, which leads to Ca2+ influx and increased neurotransmitter release.{31444} Linopirdine has been shown to produce a number of effects including EEG patterns of enhanced vigilance, induction of c-fos expression in cerebral cortex, reduction of the increase of cerebral glucose utilization induced by hypoxia, and improved performance in animal models of learning and memory.{31445} Linopirdine has also been identified as an agonist of transient receptor potential vanilloid type 1 (EC50 = 115 µM in HEK293 cells voltage clamped at -60 mV).{31442}  

     

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    Cayman
    SKU:-

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  • Linopirdine is an enhancer of the stimulus-evoked but not basal release of several neurotransmitters, including acetylcholine, dopamine, serotonin, and glutamate. It increases acetylcholine release in rat hippocampal CA1 neurons by blocking voltage-gated, calcium-activated and leak (M-type; Kv7.2/7.3; KCNQ2/3) K+ current with an IC50 value of 2.4 µM.{31443,31441} Inhibition of M-channels is reported to result in the depolarization of CA3 pyramidal neurons and activated presynaptic voltage-gated P/Q- and N-type calcium channels, which leads to Ca2+ influx and increased neurotransmitter release.{31444} Linopirdine has been shown to produce a number of effects including EEG patterns of enhanced vigilance, induction of c-fos expression in cerebral cortex, reduction of the increase of cerebral glucose utilization induced by hypoxia, and improved performance in animal models of learning and memory.{31445} Linopirdine has also been identified as an agonist of transient receptor potential vanilloid type 1 (EC50 = 115 µM in HEK293 cells voltage clamped at -60 mV).{31442}  

     

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    Cayman
    SKU:-

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  • The binding of insulin-like growth factor 1 (IGF-1) to the IGF-1 receptor (IGF-1R) promotes cell growth while inhibiting apoptotic pathways. Overexpression of IGF-1R is found in certain solid tumors and hematologic neoplasias.{31137,31135} However, insulin receptor (InsR) signaling can compensate for IGF-1R inhibition.{31134} Linsitinib is a dual inhibitor of IGF-1R and InsR kinases (IC50s = 35 and 75 nM, respectively).{31136} It also inhibits InsR-related receptor (IC50 = 75 nM) but is without effect (IC50 > 10 µM) against a large panel of other kinases.{31136} Linsitinib inhibits proliferation of a variety of tumor cell lines in vitro and has antitumor efficacy in an IGF-1R-driven xenograft mouse model when administered orally.{31136} A rapid, non-invasive method to predict the pharmacodynamic response to linsitinib has been reported.{31134}  

     

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    Cayman
    SKU:-

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  • The binding of insulin-like growth factor 1 (IGF-1) to the IGF-1 receptor (IGF-1R) promotes cell growth while inhibiting apoptotic pathways. Overexpression of IGF-1R is found in certain solid tumors and hematologic neoplasias.{31137,31135} However, insulin receptor (InsR) signaling can compensate for IGF-1R inhibition.{31134} Linsitinib is a dual inhibitor of IGF-1R and InsR kinases (IC50s = 35 and 75 nM, respectively).{31136} It also inhibits InsR-related receptor (IC50 = 75 nM) but is without effect (IC50 > 10 µM) against a large panel of other kinases.{31136} Linsitinib inhibits proliferation of a variety of tumor cell lines in vitro and has antitumor efficacy in an IGF-1R-driven xenograft mouse model when administered orally.{31136} A rapid, non-invasive method to predict the pharmacodynamic response to linsitinib has been reported.{31134}  

     

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    Cayman
    SKU:-

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  • The binding of insulin-like growth factor 1 (IGF-1) to the IGF-1 receptor (IGF-1R) promotes cell growth while inhibiting apoptotic pathways. Overexpression of IGF-1R is found in certain solid tumors and hematologic neoplasias.{31137,31135} However, insulin receptor (InsR) signaling can compensate for IGF-1R inhibition.{31134} Linsitinib is a dual inhibitor of IGF-1R and InsR kinases (IC50s = 35 and 75 nM, respectively).{31136} It also inhibits InsR-related receptor (IC50 = 75 nM) but is without effect (IC50 > 10 µM) against a large panel of other kinases.{31136} Linsitinib inhibits proliferation of a variety of tumor cell lines in vitro and has antitumor efficacy in an IGF-1R-driven xenograft mouse model when administered orally.{31136} A rapid, non-invasive method to predict the pharmacodynamic response to linsitinib has been reported.{31134}  

     

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    Cayman
    SKU:-

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  • Lipases perform essential roles in the digestion, transportation, and processing of dietary lipids by controlling the clearance of triglyceride-rich lipoproteins from the circulation. Manipulating lipolysis has therapeutic potential in the metabolic disorders frequently associated with obesity. Cayman’s Lipase Activity Assay provides a fluorescence-based method for detecting lipase activity in plasma, serum, tissue homogenates, and cell culture samples. In the assay, lipase hydrolyzes arachidonoyl-1-thioglycerol to arachidonic acid and thioglycerol. Thioglycerol reacts with the thiol fluorometric detector to yield a highly fluorescent product which can be analyzed with an excitation wavelength of 380-390 nm and an emission wavelength of 510-520 nm.  

     

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    Cayman
    SKU:700640 - 96 wells

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  • Brand:
    Cayman
    SKU:600046 - 30 ml

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  • Brand:
    Cayman
    SKU:10008981 - 1 ea

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  • Brand:
    Cayman
    SKU:600045 - 25 ml

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  • Brand:
    Cayman
    SKU:600056 - 5 ea

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  • Brand:
    Cayman
    SKU:600044 - 30 ml

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  • Cayman’s Lipid Droplets Fluorescence Assay Kit can be used to study regulators of lipid droplet biogenesis. The main advantage of this assay is that the green fluorescence of Nile Red is both very sensitive and specific for lipid droplets.{17124} Furthermore, changes in lipid droplet biogenesis in various cell types in response to different manipulations can be both qualified and quantified by fluorescence microscopy, flow cytometry, or fluorescent plate readers. Simultaneous visualization of lipid droplets and associated proteins is also possible when used with antibodies conjugated to compatible fluorophores. Oleic acid, which is commonly used to induce lipid droplet formation in cultured cells, is included as a positive control. This kit provides sufficient reagents to effectively treat/stain 480 individual wells of cells when utilized in a 96-well plate format.  

     

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    Cayman
    SKU:500001 - 480 tests

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  • Quantification of lipid peroxidation is essential to assess the role of oxidative injury in pathophysiological disorders.{1240,2997,4988} Lipid peroxidation results in the formation of highly reactive and unstable hydroperoxides of both saturated and unsaturated lipids. Our Lipid Hydroperoxide Assay Kit measures the hydroperoxides directly utilizing the redox reactions with ferrous ions.{3237} An easy to use quantitative extraction method was developed to extract lipid hydroperoxides into chloroform, and the extract is directly used in the assay. This procedure eliminates any interference caused by hydrogen peroxide or endogenous ferric ions in the sample and provides a sensitive and reliable assay for lipid peroxidation. This kit is designed for use with either a single-tube spectrophotometer to read the results or with a 96 well microplate reader. The plate used with the microplate reader is a reusable glass plate which is available with the purchase of Item No. 705003. The range of the assay is 0.25-5 nmol hydroperoxide per tube.  

     

    Brand:
    Cayman
    SKU:705002 - 100 dtn

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  • Quantification of lipid peroxidation is essential to assess the role of oxidative injury in pathophysiological disorders.{1240,2997,4988} Lipid peroxidation results in the formation of highly reactive and unstable hydroperoxides of both saturated and unsaturated lipids. Our Lipid Hydroperoxide Assay Kit measures the hydroperoxides directly utilizing the redox reactions with ferrous ions.{3237} An easy to use quantitative extraction method was developed to extract lipid hydroperoxides into chloroform, and the extract is directly used in the assay. This procedure eliminates any interference caused by hydrogen peroxide or endogenous ferric ions in the sample and provides a sensitive and reliable assay for lipid peroxidation. This kit is available in two formats: 100 dtn, which is designed to be read using a single-tube spectrophotometer, and 96 wells, which is designed to be read using a 96-well microplate reader. The 96 well kit contains a special glass plate which is resistant to organic solvents used in the assay; this is the only difference between the two kit types.  

     

    Brand:
    Cayman
    SKU:705003 - 96 wells

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  • Lipofermata is an inhibitor of fatty acid transport (IC50 = 4.84 μM in Caco-2 cells).{36945} It inhibits uptake of long- and very long-chain, but not medium-chain, fatty acids in mmC2C12, rnINS-1E, Caco-2, and HepG2 cells (IC50s = 3-6 μM).{36946} Lipofermata inhibits induction of BiP and CHOP, apoptosis, and lipid droplet accumulation, as well as reduces production of reactive oxygen species (ROS) and reverses decreases in glutathione (GSH) levels induced by palmitate (Item No. 10010279) in HepG2 and INS-1E cells. In vivo, lipofermata (500 mg/kg) inhibits absorption of 13C-oleate in mice.  

     

    Brand:
    Cayman
    SKU:25869 - 10 mg

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  • Lipofermata is an inhibitor of fatty acid transport (IC50 = 4.84 μM in Caco-2 cells).{36945} It inhibits uptake of long- and very long-chain, but not medium-chain, fatty acids in mmC2C12, rnINS-1E, Caco-2, and HepG2 cells (IC50s = 3-6 μM).{36946} Lipofermata inhibits induction of BiP and CHOP, apoptosis, and lipid droplet accumulation, as well as reduces production of reactive oxygen species (ROS) and reverses decreases in glutathione (GSH) levels induced by palmitate (Item No. 10010279) in HepG2 and INS-1E cells. In vivo, lipofermata (500 mg/kg) inhibits absorption of 13C-oleate in mice.  

     

    Brand:
    Cayman
    SKU:25869 - 25 mg

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  • Lipofermata is an inhibitor of fatty acid transport (IC50 = 4.84 μM in Caco-2 cells).{36945} It inhibits uptake of long- and very long-chain, but not medium-chain, fatty acids in mmC2C12, rnINS-1E, Caco-2, and HepG2 cells (IC50s = 3-6 μM).{36946} Lipofermata inhibits induction of BiP and CHOP, apoptosis, and lipid droplet accumulation, as well as reduces production of reactive oxygen species (ROS) and reverses decreases in glutathione (GSH) levels induced by palmitate (Item No. 10010279) in HepG2 and INS-1E cells. In vivo, lipofermata (500 mg/kg) inhibits absorption of 13C-oleate in mice.  

     

    Brand:
    Cayman
    SKU:25869 - 5 mg

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  • Lipofermata is an inhibitor of fatty acid transport (IC50 = 4.84 μM in Caco-2 cells).{36945} It inhibits uptake of long- and very long-chain, but not medium-chain, fatty acids in mmC2C12, rnINS-1E, Caco-2, and HepG2 cells (IC50s = 3-6 μM).{36946} Lipofermata inhibits induction of BiP and CHOP, apoptosis, and lipid droplet accumulation, as well as reduces production of reactive oxygen species (ROS) and reverses decreases in glutathione (GSH) levels induced by palmitate (Item No. 10010279) in HepG2 and INS-1E cells. In vivo, lipofermata (500 mg/kg) inhibits absorption of 13C-oleate in mice.  

     

    Brand:
    Cayman
    SKU:25869 - 50 mg

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  • Lipoxin A4 (LXA4) is a trihydroxy fatty acid containing a conjugated tetraene, produced by the metabolism of (±)15-HETE (Item No. 34700) or 15-HpETE with human leukocytes.{352} LXA4 is equipotent to leukotriene B4 (Item No. 20110) in inducing superoxide generation in human neutrophils at 0.1 µM.{350} LXA4 is associated with several other biological functions including leukocyte activation, chemotaxis effects, natural killer cell inhibition, and monocyte migration and adhesion.{350,354,2722} Analytical and biological comparisons of synthetic LXA4 with endogenously derived LXA4 have confirmed its identity as matching the natural product.{14569}  

     

    Brand:
    Cayman
    SKU:90410 - 100 µg

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  • Lipoxin A4 (LXA4) is a trihydroxy fatty acid containing a conjugated tetraene, produced by the metabolism of (±)15-HETE (Item No. 34700) or 15-HpETE with human leukocytes.{352} LXA4 is equipotent to leukotriene B4 (Item No. 20110) in inducing superoxide generation in human neutrophils at 0.1 µM.{350} LXA4 is associated with several other biological functions including leukocyte activation, chemotaxis effects, natural killer cell inhibition, and monocyte migration and adhesion.{350,354,2722} Analytical and biological comparisons of synthetic LXA4 with endogenously derived LXA4 have confirmed its identity as matching the natural product.{14569}  

     

    Brand:
    Cayman
    SKU:90410 - 25 µg

    Available on backorder

  • Lipoxin A4 (LXA4) is a trihydroxy fatty acid containing a conjugated tetraene, produced by the metabolism of (±)15-HETE (Item No. 34700) or 15-HpETE with human leukocytes.{352} LXA4 is equipotent to leukotriene B4 (Item No. 20110) in inducing superoxide generation in human neutrophils at 0.1 µM.{350} LXA4 is associated with several other biological functions including leukocyte activation, chemotaxis effects, natural killer cell inhibition, and monocyte migration and adhesion.{350,354,2722} Analytical and biological comparisons of synthetic LXA4 with endogenously derived LXA4 have confirmed its identity as matching the natural product.{14569}  

     

    Brand:
    Cayman
    SKU:90410 - 250 µg

    Available on backorder

  • Lipoxin A4 (LXA4) is a trihydroxy fatty acid containing a conjugated tetraene, produced by the metabolism of (±)15-HETE (Item No. 34700) or 15-HpETE with human leukocytes.{352} LXA4 is equipotent to leukotriene B4 (Item No. 20110) in inducing superoxide generation in human neutrophils at 0.1 µM.{350} LXA4 is associated with several other biological functions including leukocyte activation, chemotaxis effects, natural killer cell inhibition, and monocyte migration and adhesion.{350,354,2722} Analytical and biological comparisons of synthetic LXA4 with endogenously derived LXA4 have confirmed its identity as matching the natural product.{14569}  

     

    Brand:
    Cayman
    SKU:90410 - 50 µg

    Available on backorder

  • Lipoxin A4 (LXA4; Item No. 90410) is a part of the specialized pro-resolving mediator (SPM) family of polyunsaturated fatty acid (PUFA) metabolites.{35079} It is formed from arachidonic acid through double lipoxygenase-catalyzed reactions initiated by either 5-lipoxygenase (5-LO) followed by 12-LO/15-LO, with a leukotriene A4 (LTA4) intermediate, or by 15-LO followed by 5-LO, with 15(S)-HETE and 5(S)-Hp-15(S)-HETE intermediates. The generation of LXA4 typically requires transcellular metabolism of arachidonic acid.{35079,35339} For example, LTA4 that is synthesized in neutrophils by 5-LO is metabolized to LXA4 in platelets by 12-LO.{35339} LXA4 is released during the resolution phase of inflammation and binds to the G protein-coupled LXA4 receptor (ALX)/formyl peptide receptor (FPR2), which is located on leukocytes, and induces cell type-specific signaling.1 In macrophages, it activates phosphatidylinositol 3-kinase (PI3K) and AKT, stimulates non-phlogistic phagocytosis of apoptotic leukocytes, and inhibits apoptosis to prolong the phagocytotic phase.{11078,35388} In neutrophils, it inhibits chemotaxis and transmigration and inhibits production of LTB4 (Item No. 20110).{35389} Cayman’s LXA4 ELISA Kit is a competitive assay which can be used for quantification of LXA4. This assay has been tested in urine, serum, and plasma. The ELISA typically displays an IC50 (50% B/B0) of approximately 200 pg/ml and a detection limit (80% B/B0) of approximately 50 pg/ml.  

     

    Brand:
    Cayman
    SKU:590410 - 96 solid well

    Available on backorder

  • Lipoxin A4 (LXA4; Item No. 90410) is a part of the specialized pro-resolving mediator (SPM) family of polyunsaturated fatty acid (PUFA) metabolites.{35079} It is formed from arachidonic acid through double lipoxygenase-catalyzed reactions initiated by either 5-lipoxygenase (5-LO) followed by 12-LO/15-LO, with a leukotriene A4 (LTA4) intermediate, or by 15-LO followed by 5-LO, with 15(S)-HETE and 5(S)-Hp-15(S)-HETE intermediates. The generation of LXA4 typically requires transcellular metabolism of arachidonic acid.{35079,35339} For example, LTA4 that is synthesized in neutrophils by 5-LO is metabolized to LXA4 in platelets by 12-LO.{35339} LXA4 is released during the resolution phase of inflammation and binds to the G protein-coupled LXA4 receptor (ALX)/formyl peptide receptor (FPR2), which is located on leukocytes, and induces cell type-specific signaling.1 In macrophages, it activates phosphatidylinositol 3-kinase (PI3K) and AKT, stimulates non-phlogistic phagocytosis of apoptotic leukocytes, and inhibits apoptosis to prolong the phagocytotic phase.{11078,35388} In neutrophils, it inhibits chemotaxis and transmigration and inhibits production of LTB4 (Item No. 20110).{35389} Cayman’s LXA4 ELISA Kit is a competitive assay which can be used for quantification of LXA4. This assay has been tested in urine, serum, and plasma. The ELISA typically displays an IC50 (50% B/B0) of approximately 200 pg/ml and a detection limit (80% B/B0) of approximately 50 pg/ml.  

     

    Brand:
    Cayman
    SKU:590410 - 96 strip well

    Available on backorder

  • Lipoxin A4 (LXA4) is a trihydroxy fatty acid containing a conjugated tetraene, produced by the metabolism of 15-HETE or 15-HpETE with human leukocytes.{352} LXA4 is equipotent to leukotriene B4 (LTB4; Item Nos. 10007240 | 20110) in inducing superoxide generation in human neutrophils at 0.1 µM.{350} LXA4 is associated with several other biological functions including leukocyte activation, chemotaxis effects, natural killer cell inhibition, and monocyte migration and adhesion.{350,354,2722} LXA4 MaxSpec® standard is a quantitative grade standard of LXA4 (Item No. 90410) that has been prepared specifically for mass spectrometry and related applications where quantitative reproducibility is required. The solution has been prepared gravimetrically and is supplied in a deactivated glass ampule sealed under argon. The concentration was verified by comparison to an independently prepared calibration standard. This LXA4 MaxSpec® standard is guaranteed to meet identity, purity, stability, and concentration specifications and is provided with a batch-specific certificate of analysis. Ongoing stability testing is performed to ensure the concentration remains accurate throughout the shelf life of the product. Note: The amount of solution added to the vial is in excess of the listed amount. Therefore, it is necessary to accurately measure volumes for preparation of calibration standards. Follow recommended storage and handling conditions to maintain product quality.  

     

    Brand:
    Cayman
    SKU:10007271 - 10 µg

    Available on backorder

  • Lipoxin A4 methyl ester (LXA4 methyl ester) is a more lipid soluble, prodrug formulation of the transcellular metabolite LXA4. LXA4 is a trihydroxy fatty acid containing a conjugated tetraene, produced by the metabolism of 15-HETE or 15-HpETE with human leukocytes.{352} LXA4 is equipotent to leukotriene B4 (LTB4) in inducing superoxide generation in human neutrophils at 0.1 µM.{350} LXA4 is associated with several other biological functions including leukocyte activation, chemotaxis effects, natural killer cell inhibition, and monocyte migration and adhesion.{350,354,2722}  

     

    Brand:
    Cayman
    SKU:10033 - 100 µg

    Available on backorder

  • Lipoxin A4 methyl ester (LXA4 methyl ester) is a more lipid soluble, prodrug formulation of the transcellular metabolite LXA4. LXA4 is a trihydroxy fatty acid containing a conjugated tetraene, produced by the metabolism of 15-HETE or 15-HpETE with human leukocytes.{352} LXA4 is equipotent to leukotriene B4 (LTB4) in inducing superoxide generation in human neutrophils at 0.1 µM.{350} LXA4 is associated with several other biological functions including leukocyte activation, chemotaxis effects, natural killer cell inhibition, and monocyte migration and adhesion.{350,354,2722}  

     

    Brand:
    Cayman
    SKU:10033 - 25 µg

    Available on backorder

  • Lipoxin A4 methyl ester (LXA4 methyl ester) is a more lipid soluble, prodrug formulation of the transcellular metabolite LXA4. LXA4 is a trihydroxy fatty acid containing a conjugated tetraene, produced by the metabolism of 15-HETE or 15-HpETE with human leukocytes.{352} LXA4 is equipotent to leukotriene B4 (LTB4) in inducing superoxide generation in human neutrophils at 0.1 µM.{350} LXA4 is associated with several other biological functions including leukocyte activation, chemotaxis effects, natural killer cell inhibition, and monocyte migration and adhesion.{350,354,2722}  

     

    Brand:
    Cayman
    SKU:10033 - 50 µg

    Available on backorder

  • Lipoxin A4-d5 (LXA4-d5) contains five deuterium atoms at the 19, 19’, 20, 20, and 20 positions. It is intended for use as an internal standard for the quantification of LXA4 by GC- or LC-mass spectrometry (MS). LXA4 is a trihydroxy fatty acid containing a conjugated tetraene, produced by the metabolism of 15-HETE or 15-HpETE with human leukocytes.{352} LXA4 is equipotent to leukotriene B4 (LTB4) in inducing superoxide generation in human neutrophils at 0.1 µM.{350} LXA4 is associated with several other biological functions including leukocyte activation, chemotaxis effects, natural killer cell inhibition, and monocyte migration and adhesion.{350,354,2722}  

     

    Brand:
    Cayman
    SKU:10007737 - 10 µg

    Available on backorder

  • Lipoxin A4-d5 (LXA4-d5) contains five deuterium atoms at the 19, 19’, 20, 20, and 20 positions. It is intended for use as an internal standard for the quantification of LXA4 by GC- or LC-mass spectrometry (MS). LXA4 is a trihydroxy fatty acid containing a conjugated tetraene, produced by the metabolism of 15-HETE or 15-HpETE with human leukocytes.{352} LXA4 is equipotent to leukotriene B4 (LTB4) in inducing superoxide generation in human neutrophils at 0.1 µM.{350} LXA4 is associated with several other biological functions including leukocyte activation, chemotaxis effects, natural killer cell inhibition, and monocyte migration and adhesion.{350,354,2722}  

     

    Brand:
    Cayman
    SKU:10007737 - 100 µg

    Available on backorder

  • Lipoxin A4-d5 (LXA4-d5) contains five deuterium atoms at the 19, 19’, 20, 20, and 20 positions. It is intended for use as an internal standard for the quantification of LXA4 by GC- or LC-mass spectrometry (MS). LXA4 is a trihydroxy fatty acid containing a conjugated tetraene, produced by the metabolism of 15-HETE or 15-HpETE with human leukocytes.{352} LXA4 is equipotent to leukotriene B4 (LTB4) in inducing superoxide generation in human neutrophils at 0.1 µM.{350} LXA4 is associated with several other biological functions including leukocyte activation, chemotaxis effects, natural killer cell inhibition, and monocyte migration and adhesion.{350,354,2722}  

     

    Brand:
    Cayman
    SKU:10007737 - 25 µg

    Available on backorder

  • Lipoxin A4-d5 (LXA4-d5) contains five deuterium atoms at the 19, 19’, 20, 20, and 20 positions. It is intended for use as an internal standard for the quantification of LXA4 by GC- or LC-mass spectrometry (MS). LXA4 is a trihydroxy fatty acid containing a conjugated tetraene, produced by the metabolism of 15-HETE or 15-HpETE with human leukocytes.{352} LXA4 is equipotent to leukotriene B4 (LTB4) in inducing superoxide generation in human neutrophils at 0.1 µM.{350} LXA4 is associated with several other biological functions including leukocyte activation, chemotaxis effects, natural killer cell inhibition, and monocyte migration and adhesion.{350,354,2722}  

     

    Brand:
    Cayman
    SKU:10007737 - 50 µg

    Available on backorder

  • Lipoxin A4-d5 (LXA4-d5) is intended for use as an internal standard for the quantification of LXA4 (Item Nos. 90410 | 10007271) by GC- or LC-mass spectrometry (MS). LXA4 is a trihydroxy fatty acid containing a conjugated tetraene, produced by the metabolism of 15-HETE or 15-HpETE with human leukocytes.{352} LXA4 is equipotent to leukotriene B4 (LTB4; Item Nos. 20110 | 10007240) in inducing superoxide generation in human neutrophils at 0.1 µM.{350} LXA4 is associated with several other biological functions including leukocyte activation, chemotaxis effects, natural killer cell inhibition, and monocyte migration and adhesion.{350,354,2722} LXA4-d5 MaxSpec® standard is a quantitative grade standard of LXA4-d5 (Item No. 10007737) that has been prepared specifically for mass spectrometry and related applications where quantitative reproducibility is required. The solution has been prepared gravimetrically and is supplied in a deactivated glass ampule sealed under argon. The concentration was verified by comparison to an independently prepared calibration standard. This LXA4-d5 MaxSpec® standard is guaranteed to meet identity, purity, stability, and concentration specifications and is provided with a batch-specific certificate of analysis. Ongoing stability testing is performed to ensure the concentration remains accurate throughout the shelf life of the product. Note: The amount of solution added to the vial is in excess of the listed amount. Therefore, it is necessary to accurately measure volumes for preparation of calibration standards. Follow recommended storage and handling conditions to maintain product quality.  

     

    Brand:
    Cayman
    SKU:24936 - 10 µg

    Available on backorder

  • Lipoxin A5 (LXA5) is produced by enzymatic transformation of EPA by leukocytes.{15471} LXA5 slowly contracts pulmonary parenchymal strips from guinea pig with similar potency to that of LXA4 and LXB4.{15472} However, LXA5 does not exert the vasodilatory effects on aortic smooth muscle exhibited by LXA4 and LXB4.{15472}  

     

    Brand:
    Cayman
    SKU:10011453 - 100 µg

    Available on backorder

  • Lipoxin A5 (LXA5) is produced by enzymatic transformation of EPA by leukocytes.{15471} LXA5 slowly contracts pulmonary parenchymal strips from guinea pig with similar potency to that of LXA4 and LXB4.{15472} However, LXA5 does not exert the vasodilatory effects on aortic smooth muscle exhibited by LXA4 and LXB4.{15472}  

     

    Brand:
    Cayman
    SKU:10011453 - 25 µg

    Available on backorder

  • Lipoxin A5 (LXA5) is produced by enzymatic transformation of EPA by leukocytes.{15471} LXA5 slowly contracts pulmonary parenchymal strips from guinea pig with similar potency to that of LXA4 and LXB4.{15472} However, LXA5 does not exert the vasodilatory effects on aortic smooth muscle exhibited by LXA4 and LXB4.{15472}  

     

    Brand:
    Cayman
    SKU:10011453 - 50 µg

    Available on backorder

  • Lipoxin B4 (LXB4) is a positional isomer of LXA4 (Item No. 90410) produced by the metabolism of 15-HETE (Item No. 34700) or 15(S)-HpETE (Item No. 44720) by human leukocytes.{369,350} At a concentration of 100 nM, LXB4 inhibits polymorphonuclear leukocyte (PMN) migration stimulated by leukotriene B4 (LTB4; Item No. 20110) and inhibits LTB4-induced adhesion of PMNs with an IC50 value of 0.3 nM.{16457}  

     

    Brand:
    Cayman
    SKU:90420 - 100 µg

    Available on backorder

  • Lipoxin B4 (LXB4) is a positional isomer of LXA4 (Item No. 90410) produced by the metabolism of 15-HETE (Item No. 34700) or 15(S)-HpETE (Item No. 44720) by human leukocytes.{369,350} At a concentration of 100 nM, LXB4 inhibits polymorphonuclear leukocyte (PMN) migration stimulated by leukotriene B4 (LTB4; Item No. 20110) and inhibits LTB4-induced adhesion of PMNs with an IC50 value of 0.3 nM.{16457}  

     

    Brand:
    Cayman
    SKU:90420 - 25 µg

    Available on backorder

  • Lipoxin B4 (LXB4) is a positional isomer of LXA4 (Item No. 90410) produced by the metabolism of 15-HETE (Item No. 34700) or 15(S)-HpETE (Item No. 44720) by human leukocytes.{369,350} At a concentration of 100 nM, LXB4 inhibits polymorphonuclear leukocyte (PMN) migration stimulated by leukotriene B4 (LTB4; Item No. 20110) and inhibits LTB4-induced adhesion of PMNs with an IC50 value of 0.3 nM.{16457}  

     

    Brand:
    Cayman
    SKU:90420 - 50 µg

    Available on backorder

  • Cayman’s Lipoxin B4 (LXB4) ELISA Kit is a competitive assay that can be used for quantification of LXB4 in plasma, serum, and urine. The assay has a range of 1.6-1,000 pg/ml with a midpoint (50% B/B0) of approximately 41 pg/ml and a sensitivity (80% B/B0) of approximately 9.5 pg/ml.  

     

    Brand:
    Cayman
    SKU:501920 - 96 solid well

    Available on backorder

  • Cayman’s Lipoxin B4 (LXB4) ELISA Kit is a competitive assay that can be used for quantification of LXB4 in plasma, serum, and urine. The assay has a range of 1.6-1,000 pg/ml with a midpoint (50% B/B0) of approximately 41 pg/ml and a sensitivity (80% B/B0) of approximately 9.5 pg/ml.  

     

    Brand:
    Cayman
    SKU:501920 - 96 strip well

    Available on backorder

  • Lipoxin B4 ELISA Polyclonal Antiserum has been tested and formulated to work exclusively with Cayman’s Lipoxin B4 ELISA Kit (Item No. 501920). Please visit Lipoxin B4 ELISA Kit (Item No. 501920) for the kit protocol, procedures, and product handling.  

     

    Brand:
    Cayman
    SKU:401922 - 100 dtn

    Available on backorder

  • Lipoxin B4 ELISA Standard has been tested and formulated to work exclusively with Cayman’s Lipoxin B4 ELISA Kit (Item No. 501920). Please visit Lipoxin B4 ELISA Kit (Item No. 501920) for the kit protocol, procedures, and product handling.  

     

    Brand:
    Cayman
    SKU:401924 - 25 ng

    Available on backorder