Cayman
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Lactisole is an antagonist of sweet taste receptors, reducing both sweetness intensity and persistence.{30372,30375} It blocks the activation of the sweet taste receptor T1R3 by natural and synthetic sweeteners and increases the inhibition of T1R2 by umami compounds.{30371,30376} Lactisole can be used to explore the roles of these receptors in diverse pathways, including glucose-induced insulin secretion in pancreatic β-cells and the secretion of glucagon-like peptides by enteroendocrine L-cells.{30371,30373,30374}
Brand:CaymanSKU:-Available on backorder
Lactisole is an antagonist of sweet taste receptors, reducing both sweetness intensity and persistence.{30372,30375} It blocks the activation of the sweet taste receptor T1R3 by natural and synthetic sweeteners and increases the inhibition of T1R2 by umami compounds.{30371,30376} Lactisole can be used to explore the roles of these receptors in diverse pathways, including glucose-induced insulin secretion in pancreatic β-cells and the secretion of glucagon-like peptides by enteroendocrine L-cells.{30371,30373,30374}
Brand:CaymanSKU:-Available on backorder
Lactisole is an antagonist of sweet taste receptors, reducing both sweetness intensity and persistence.{30372,30375} It blocks the activation of the sweet taste receptor T1R3 by natural and synthetic sweeteners and increases the inhibition of T1R2 by umami compounds.{30371,30376} Lactisole can be used to explore the roles of these receptors in diverse pathways, including glucose-induced insulin secretion in pancreatic β-cells and the secretion of glucagon-like peptides by enteroendocrine L-cells.{30371,30373,30374}
Brand:CaymanSKU:-Available on backorder
Lactisole is an antagonist of sweet taste receptors, reducing both sweetness intensity and persistence.{30372,30375} It blocks the activation of the sweet taste receptor T1R3 by natural and synthetic sweeteners and increases the inhibition of T1R2 by umami compounds.{30371,30376} Lactisole can be used to explore the roles of these receptors in diverse pathways, including glucose-induced insulin secretion in pancreatic β-cells and the secretion of glucagon-like peptides by enteroendocrine L-cells.{30371,30373,30374}
Brand:CaymanSKU:-Available on backorder
Lactosylceramide (LacCer) is an endogenous bioactive sphingolipid. It is expressed on the plasma membrane of human phagocytes and mediates phagocytosis, chemotaxis, and superoxide generation.{41044} LacCer forms membrane microdomains with Lyn kinase and the αi subunits of inhibitory G protein-coupled receptors, suggesting a role in cell signaling. Elevated LacCer levels in kidney cortex homogenates and urine are directly correlated with hyperglycemia, insulin resistance, and obesity in db/db transgenic diabetic mice.{41045} It promotes recruitment of CNS-infiltrating monocytes and microglia and enhances neurodegeneration in mice with chronic experimental autoimmune encephalomyelitis (EAE), a model of multiple sclerosis (MS).{27728} Increased levels of LacCer in atherosclerotic plaques are correlated with increased levels of the pro-inflammatory cytokines IL-6, monocyte chemoattractant protein-1 (MCP-1), and macrophage inflammatory protein 1β (MIP-1β), as well as lipids and macrophages.{41046} LacCer is also upregulated during the secretory phase of the menstrual cycle.{41047} This product is a mixture of LacCers isolated from bovine buttermilk with variable N-acyl chain lengths. [Matreya, LLC. Catalog No. 1507]
Brand:CaymanSKU:27197 - 1 mgAvailable on backorder
Lactosylceramide (LacCer) is an endogenous bioactive sphingolipid. It is expressed on the plasma membrane of human phagocytes and mediates phagocytosis, chemotaxis, and superoxide generation.{41044} LacCer forms membrane microdomains with Lyn kinase and the αi subunits of inhibitory G protein-coupled receptors, suggesting a role in cell signaling. Elevated LacCer levels in kidney cortex homogenates and urine are directly correlated with hyperglycemia, insulin resistance, and obesity in db/db transgenic diabetic mice.{41045} It promotes recruitment of CNS-infiltrating monocytes and microglia and enhances neurodegeneration in mice with chronic experimental autoimmune encephalomyelitis (EAE), a model of multiple sclerosis (MS).{27728} Increased levels of LacCer in atherosclerotic plaques are correlated with increased levels of the pro-inflammatory cytokines IL-6, monocyte chemoattractant protein-1 (MCP-1), and macrophage inflammatory protein 1β (MIP-1β), as well as lipids and macrophages.{41046} LacCer is also upregulated during the secretory phase of the menstrual cycle.{41047} This product is a mixture of LacCers isolated from bovine buttermilk with variable N-acyl chain lengths. [Matreya, LLC. Catalog No. 1507]
Brand:CaymanSKU:27197 - 10 mgAvailable on backorder
Lactosylceramide (LacCer) is an endogenous bioactive sphingolipid. It is expressed on the plasma membrane of human phagocytes and mediates phagocytosis, chemotaxis, and superoxide generation.{41044} LacCer forms membrane microdomains with Lyn kinase and the αi subunits of inhibitory G protein-coupled receptors, suggesting a role in cell signaling. Elevated LacCer levels in kidney cortex homogenates and urine are directly correlated with hyperglycemia, insulin resistance, and obesity in db/db transgenic diabetic mice.{41045} It promotes recruitment of CNS-infiltrating monocytes and microglia and enhances neurodegeneration in mice with chronic experimental autoimmune encephalomyelitis (EAE), a model of multiple sclerosis (MS).{27728} Increased levels of LacCer in atherosclerotic plaques are correlated with increased levels of the pro-inflammatory cytokines IL-6, monocyte chemoattractant protein-1 (MCP-1), and macrophage inflammatory protein 1β (MIP-1β), as well as lipids and macrophages.{41046} LacCer is also upregulated during the secretory phase of the menstrual cycle.{41047} This product is a mixture of LacCers isolated from bovine buttermilk with variable N-acyl chain lengths. [Matreya, LLC. Catalog No. 1507]
Brand:CaymanSKU:27197 - 5 mgAvailable on backorder
Lactosylceramide (LacCer) is an endogenous bioactive sphingolipid. It is expressed on the plasma membrane of human phagocytes and mediates phagocytosis, chemotaxis, and superoxide generation.{41044} LacCer forms membrane microdomains with Lyn kinase and the αi subunits of inhibitory G protein-coupled receptors, suggesting a role in cell signaling. Elevated LacCer levels in kidney cortex homogenates and urine are directly correlated with hyperglycemia, insulin resistance, and obesity in db/db transgenic diabetic mice.{41045} It promotes recruitment of CNS-infiltrating monocytes and microglia and enhances neurodegeneration in mice with chronic experimental autoimmune encephalomyelitis (EAE), a model of multiple sclerosis (MS).{27728} Increased levels of LacCer in atherosclerotic plaques are correlated with increased levels of the pro-inflammatory cytokines IL-6, monocyte chemoattractant protein-1 (MCP-1), and macrophage inflammatory protein 1β (MIP-1β), as well as lipids and macrophages.{41046} LacCer is also upregulated during the secretory phase of the menstrual cycle.{41047} This product is a mixture of LacCers isolated from bovine buttermilk with variable N-acyl chain lengths. [Matreya, LLC. Catalog No. 1507]
Brand:CaymanSKU:27197 - 50 mgAvailable on backorder
Lactosylsphingosine is a bioactive sphingolipid and a form of lactosylceramide (Item No. 16983) that is lacking the fatty acyl group. Lyso-lactosylceramide (1-50 μM) reduces viability of human neutrophils in a concentration-dependent manner.{38972} Unlike lactosylceramide,lactosylsphingosine has no effect on protein synthesis and cell proliferation in cardiomyocytes.{38973} Lactosylsphingosine is a precursor in the synthesis of lyso-ganglioside GM3.{38974} [Matreya, LLC. Catalog No. 1517]
Brand:CaymanSKU:24868 - 1 mgAvailable on backorder
Lactosylsphingosine is a bioactive sphingolipid and a form of lactosylceramide (Item No. 16983) that is lacking the fatty acyl group. Lyso-lactosylceramide (1-50 μM) reduces viability of human neutrophils in a concentration-dependent manner.{38972} Unlike lactosylceramide, Lactosylsphingosine has no effect on protein synthesis and cell proliferation in cardiomyocytes.{38973} Lactosylsphingosine is a precursor in the synthesis of lyso-ganglioside GM3.{38974} [Matreya, LLC. Catalog No. 2088]
Brand:CaymanSKU:24867 - 1 mgAvailable on backorder
Lactulose is a synthetic and non-digestible sugar.{36272} It reduces colonic pH to 3.5 and stimulates circular muscle activity and propulsion of fluid in isolated guinea pig ileum and colon. Formulations containing lactulose have been used to treat constipation.
Brand:CaymanSKU:23795 - 1 gAvailable on backorder
Lactulose is a synthetic and non-digestible sugar.{36272} It reduces colonic pH to 3.5 and stimulates circular muscle activity and propulsion of fluid in isolated guinea pig ileum and colon. Formulations containing lactulose have been used to treat constipation.
Brand:CaymanSKU:23795 - 5 gAvailable on backorder
Lafutidine is a histamine H2 receptor antagonist with gastroprotective activity.{53634} It inhibits histamine-induced cAMP production in CHO cells expressing human histamine H2 receptors when used at a concentration of 10 nM. Intragastric administration of lafutidine (3, 10, and 30 mg/kg) reduces hemorrhagic esophageal lesion size and gastric acid secretion in a rat model of pyloric ligation-induced reflux esophagitis.{53635} It prevents 5-fluorouracil-induced intestinal mucositis, diarrhea, and body weight loss in wild-type, but not Trpv1-/- or sensory deafferented, mice when administered at doses ranging from 3 to 30 mg/kg.{53636} Lafutidine (10 mg/kg) also reduces indomethacin-induced antral ulcer size in wild-type, but not chemically-deafferented, rats.{7826}
Brand:CaymanSKU:30275 - 100 mgAvailable on backorder
Lafutidine is a histamine H2 receptor antagonist with gastroprotective activity.{53634} It inhibits histamine-induced cAMP production in CHO cells expressing human histamine H2 receptors when used at a concentration of 10 nM. Intragastric administration of lafutidine (3, 10, and 30 mg/kg) reduces hemorrhagic esophageal lesion size and gastric acid secretion in a rat model of pyloric ligation-induced reflux esophagitis.{53635} It prevents 5-fluorouracil-induced intestinal mucositis, diarrhea, and body weight loss in wild-type, but not Trpv1-/- or sensory deafferented, mice when administered at doses ranging from 3 to 30 mg/kg.{53636} Lafutidine (10 mg/kg) also reduces indomethacin-induced antral ulcer size in wild-type, but not chemically-deafferented, rats.{7826}
Brand:CaymanSKU:30275 - 25 mgAvailable on backorder
Lafutidine is a histamine H2 receptor antagonist with gastroprotective activity.{53634} It inhibits histamine-induced cAMP production in CHO cells expressing human histamine H2 receptors when used at a concentration of 10 nM. Intragastric administration of lafutidine (3, 10, and 30 mg/kg) reduces hemorrhagic esophageal lesion size and gastric acid secretion in a rat model of pyloric ligation-induced reflux esophagitis.{53635} It prevents 5-fluorouracil-induced intestinal mucositis, diarrhea, and body weight loss in wild-type, but not Trpv1-/- or sensory deafferented, mice when administered at doses ranging from 3 to 30 mg/kg.{53636} Lafutidine (10 mg/kg) also reduces indomethacin-induced antral ulcer size in wild-type, but not chemically-deafferented, rats.{7826}
Brand:CaymanSKU:30275 - 250 mgAvailable on backorder
Lafutidine is a histamine H2 receptor antagonist with gastroprotective activity.{53634} It inhibits histamine-induced cAMP production in CHO cells expressing human histamine H2 receptors when used at a concentration of 10 nM. Intragastric administration of lafutidine (3, 10, and 30 mg/kg) reduces hemorrhagic esophageal lesion size and gastric acid secretion in a rat model of pyloric ligation-induced reflux esophagitis.{53635} It prevents 5-fluorouracil-induced intestinal mucositis, diarrhea, and body weight loss in wild-type, but not Trpv1-/- or sensory deafferented, mice when administered at doses ranging from 3 to 30 mg/kg.{53636} Lafutidine (10 mg/kg) also reduces indomethacin-induced antral ulcer size in wild-type, but not chemically-deafferented, rats.{7826}
Brand:CaymanSKU:30275 - 50 mgAvailable on backorder
Plants from the mint genus Lagochilus have been used in traditional medicines of the east.{21776} Lagochiline is a polyphenolic natural product isolated from Lagochilus spp. which is thought to provide some of the benefits of the herb. The physiological, immunological, and toxicological properties of this compound remain to be determined. This product is intended for research and forensic purposes.
Brand:CaymanSKU:- Plants from the mint genus Lagochilus have been used in traditional medicines of the east.{21776} Lagochiline is a polyphenolic natural product isolated from Lagochilus spp. which is thought to provide some of the benefits of the herb. The physiological, immunological, and toxicological properties of this compound remain to be determined. This product is intended for research and forensic purposes.
Brand:CaymanSKU:- Plants from the mint genus Lagochilus have been used in traditional medicines of the east.{21776} Lagochiline is a polyphenolic natural product isolated from Lagochilus spp. which is thought to provide some of the benefits of the herb. The physiological, immunological, and toxicological properties of this compound remain to be determined. This product is intended for research and forensic purposes.
Brand:CaymanSKU:-
Lagosin is a polyene macrolide antibiotic first obtained from an isolate of a Streptomyces species present in a sample of soil collected in Lagos, Nigeria. It is the most polar member of the filipin family of fungicides and exhibits broad spectrum antifungal and antitumor activity, acting via interaction with cell membrane sterols.{32135,32134}
Brand:CaymanSKU:20600 -Available on backorder
Lagosin is a polyene macrolide antibiotic first obtained from an isolate of a Streptomyces species present in a sample of soil collected in Lagos, Nigeria. It is the most polar member of the filipin family of fungicides and exhibits broad spectrum antifungal and antitumor activity, acting via interaction with cell membrane sterols.{32135,32134}
Brand:CaymanSKU:20600 -Available on backorder
Lalistat 1 is an inhibitor of lysosomal acid lipase (LAL; IC50 = 68 nM using purified human LAL).{36492} It is selective for LAL over human pancreatic and bovine milk lipoprotein lipases up to a concentration of 10 µM.{36493} Lalistat 1 (0.01-10 µM) reduces cholesterol accumulation in lysosome-like storage organelles in GM03123 human fibroblast cells deficient in NPC1, a membrane protein found in late endosomes, in a concentration-dependent manner but has little effect on cholesterol accumulation in NPC1-deficient CHO cells.
Brand:CaymanSKU:23891 - 1 mgAvailable on backorder
Lalistat 1 is an inhibitor of lysosomal acid lipase (LAL; IC50 = 68 nM using purified human LAL).{36492} It is selective for LAL over human pancreatic and bovine milk lipoprotein lipases up to a concentration of 10 µM.{36493} Lalistat 1 (0.01-10 µM) reduces cholesterol accumulation in lysosome-like storage organelles in GM03123 human fibroblast cells deficient in NPC1, a membrane protein found in late endosomes, in a concentration-dependent manner but has little effect on cholesterol accumulation in NPC1-deficient CHO cells.
Brand:CaymanSKU:23891 - 10 mgAvailable on backorder
Lalistat 1 is an inhibitor of lysosomal acid lipase (LAL; IC50 = 68 nM using purified human LAL).{36492} It is selective for LAL over human pancreatic and bovine milk lipoprotein lipases up to a concentration of 10 µM.{36493} Lalistat 1 (0.01-10 µM) reduces cholesterol accumulation in lysosome-like storage organelles in GM03123 human fibroblast cells deficient in NPC1, a membrane protein found in late endosomes, in a concentration-dependent manner but has little effect on cholesterol accumulation in NPC1-deficient CHO cells.
Brand:CaymanSKU:23891 - 50 mgAvailable on backorder
Lalistat 2 is an inhibitor of lysosomal acid lipase (LAL; IC50 = 152 nM using purified human LAL).{36493} It blocks lipid clearance induced by the autophagy enhancers MSL and MSL-7 in HeLa cells preloaded with palmitic acid (Item No. 10006627) and oleic acid (Item No. 90260).{43081}
Brand:CaymanSKU:25347 - 10 mgAvailable on backorder
Lalistat 2 is an inhibitor of lysosomal acid lipase (LAL; IC50 = 152 nM using purified human LAL).{36493} It blocks lipid clearance induced by the autophagy enhancers MSL and MSL-7 in HeLa cells preloaded with palmitic acid (Item No. 10006627) and oleic acid (Item No. 90260).{43081}
Brand:CaymanSKU:25347 - 100 mgAvailable on backorder
Lalistat 2 is an inhibitor of lysosomal acid lipase (LAL; IC50 = 152 nM using purified human LAL).{36493} It blocks lipid clearance induced by the autophagy enhancers MSL and MSL-7 in HeLa cells preloaded with palmitic acid (Item No. 10006627) and oleic acid (Item No. 90260).{43081}
Brand:CaymanSKU:25347 - 5 mgAvailable on backorder
Lalistat 2 is an inhibitor of lysosomal acid lipase (LAL; IC50 = 152 nM using purified human LAL).{36493} It blocks lipid clearance induced by the autophagy enhancers MSL and MSL-7 in HeLa cells preloaded with palmitic acid (Item No. 10006627) and oleic acid (Item No. 90260).{43081}
Brand:CaymanSKU:25347 - 50 mgAvailable on backorder
Laminin (925-933) is a peptide fragment corresponding to the laminin β1 chain.{61005} It binds to the laminin receptor when used at a concentration of 1 mg/ml. Laminin (925-933) stimulates the attachment of HT-1080 and CHO cells to culture plates when used at concentrations of 100 and 300 µg/ml. It induces chemotaxis of, as well as inhibits chemotaxis induced by full-length laminin, but not fibronectin, in B16/F10 murine melanoma cells. Laminin (925-933) conjugated to an agarose hydrogel backbone enhances neurite outgrowth in isolated chick embryo dorsal root ganglia and PC12 cells.{61006}
Brand:CaymanSKU:31141 - 1 mgAvailable on backorder
Laminin (925-933) is a peptide fragment corresponding to the laminin β1 chain.{61005} It binds to the laminin receptor when used at a concentration of 1 mg/ml. Laminin (925-933) stimulates the attachment of HT-1080 and CHO cells to culture plates when used at concentrations of 100 and 300 µg/ml. It induces chemotaxis of, as well as inhibits chemotaxis induced by full-length laminin, but not fibronectin, in B16/F10 murine melanoma cells. Laminin (925-933) conjugated to an agarose hydrogel backbone enhances neurite outgrowth in isolated chick embryo dorsal root ganglia and PC12 cells.{61006}
Brand:CaymanSKU:31141 - 10 mgAvailable on backorder
Laminin (925-933) is a peptide fragment corresponding to the laminin β1 chain.{61005} It binds to the laminin receptor when used at a concentration of 1 mg/ml. Laminin (925-933) stimulates the attachment of HT-1080 and CHO cells to culture plates when used at concentrations of 100 and 300 µg/ml. It induces chemotaxis of, as well as inhibits chemotaxis induced by full-length laminin, but not fibronectin, in B16/F10 murine melanoma cells. Laminin (925-933) conjugated to an agarose hydrogel backbone enhances neurite outgrowth in isolated chick embryo dorsal root ganglia and PC12 cells.{61006}
Brand:CaymanSKU:31141 - 5 mgAvailable on backorder
Lamivudine is a cytidine analog that inhibits the reverse transcriptases of HIV1 (IC50 = 45 nM), HIV2, and hepatitis B.{29846,22165} It was one of the first approved nucleoside analog reverse transcriptase inhibitors used to treat viral infections. Following prolonged administration, the efficacy of lamivudine is associated with drug resistance, which may be improved through combination treatments.{23834,24185}
Brand:CaymanSKU:-Available on backorder
Lamivudine is a cytidine analog that inhibits the reverse transcriptases of HIV1 (IC50 = 45 nM), HIV2, and hepatitis B.{29846,22165} It was one of the first approved nucleoside analog reverse transcriptase inhibitors used to treat viral infections. Following prolonged administration, the efficacy of lamivudine is associated with drug resistance, which may be improved through combination treatments.{23834,24185}
Brand:CaymanSKU:-Available on backorder
Lamivudine is a cytidine analog that inhibits the reverse transcriptases of HIV1 (IC50 = 45 nM), HIV2, and hepatitis B.{29846,22165} It was one of the first approved nucleoside analog reverse transcriptase inhibitors used to treat viral infections. Following prolonged administration, the efficacy of lamivudine is associated with drug resistance, which may be improved through combination treatments.{23834,24185}
Brand:CaymanSKU:-Available on backorder
Lamivudine is a cytidine analog that inhibits the reverse transcriptases of HIV1 (IC50 = 45 nM), HIV2, and hepatitis B.{29846,22165} It was one of the first approved nucleoside analog reverse transcriptase inhibitors used to treat viral infections. Following prolonged administration, the efficacy of lamivudine is associated with drug resistance, which may be improved through combination treatments.{23834,24185}
Brand:CaymanSKU:-Available on backorder
Lamotrigine is an inhibitor of voltage-gated sodium channels (Nav), blocking human Nav1.2, Nav1.5, and Nav1.8 with IC50 values of 10, 62, and 96 μM, respectively.{25270,25272} Presumably through this action, lamotrigine acts as an anticonvulsant and has applications in many diseases that feature seizures, including epilepsy and autism spectrum disorder.{25269,25271}
Brand:CaymanSKU:- Lamotrigine is an inhibitor of voltage-gated sodium channels (Nav), blocking human Nav1.2, Nav1.5, and Nav1.8 with IC50 values of 10, 62, and 96 μM, respectively.{25270,25272} Presumably through this action, lamotrigine acts as an anticonvulsant and has applications in many diseases that feature seizures, including epilepsy and autism spectrum disorder.{25269,25271}
Brand:CaymanSKU:- Lamotrigine is an inhibitor of voltage-gated sodium channels (Nav), blocking human Nav1.2, Nav1.5, and Nav1.8 with IC50 values of 10, 62, and 96 μM, respectively.{25270,25272} Presumably through this action, lamotrigine acts as an anticonvulsant and has applications in many diseases that feature seizures, including epilepsy and autism spectrum disorder.{25269,25271}
Brand:CaymanSKU:- Lamotrigine is an inhibitor of voltage-gated sodium channels (Nav), blocking human Nav1.2, Nav1.5, and Nav1.8 with IC50 values of 10, 62, and 96 μM, respectively.{25270,25272} Presumably through this action, lamotrigine acts as an anticonvulsant and has applications in many diseases that feature seizures, including epilepsy and autism spectrum disorder.{25269,25271}
Brand:CaymanSKU:-
Antigen: rat liver lysosomal membrane preparations · Host: mouse, clone Ly1C6 · Isotype: IgG1 · Cross-reactivity: (+) rat and hamster LAMP1 · Applications: WB, IP, and ICC
Brand:CaymanSKU:10011443- 100 µg Lysosome associated membrane protein 1 (LAMP1) and LAMP2 are major constituents of the lysosomal membrane. The two have closely related structures, with 37% sequence homology.{15782} They are both transmembrane glycoproteins that are localized primarily in lysosomes and late endosomes. Newly synthesized molecules are mostly transported from the trans-Golgi network directly to endosomes and then to lysosomes. A second pathway involves the LAMPs being delivered from the Golgi to the cell surface, and then along the endocytic pathway to the lysosomes. A minor pathway involves transport via the plasma membrane.{15783} Upon stimulation, a rapid translocation of intracellular LAMPs to the cell membrane is dependent on a carboxyl-terminal tyrosine based motif (YXXI).{15845} If there is a disturbance in this spacing, lysosome localization of LAMP1 is abolished and the mutant protein then cycles between the membrane and the endosome.{15783} This stimulation has also been shown to have an associated release of histamine, leukotriene C4 and prostaglandin D2, which shows that LAMP1 and LAMP2 are activation markers for normal mast cells.{15845} They have also been linked to the inflammatory response in that they promote adhesion of human peripheral blood mononuclear cells (PBMC) to vascular endothelium and therefore possibly adhesion of PBMC to the site of inflammation.{15784}
Brand:CaymanSKU:10011443 - 100 µgAvailable on backorder
Antigen: rat liver lysosomal membrane preparations · Host: mouse, clone Ly1C6 · Isotype: IgG1 · Cross-reactivity: (+) rat and hamster LAMP1 · Applications: WB, IP, and ICC
Brand:CaymanSKU:10011443- 100 µgAvailable on backorder
Antigen: rat liver lysosomal membrane preparations · Host: mouse, clone Ly1C6 · Isotype: IgG1 · Cross-reactivity: (+) rat and hamster LAMP1 · Applications: WB, IP, and ICC
Brand:CaymanSKU:10011443- 25 µg Lysosome associated membrane protein 1 (LAMP1) and LAMP2 are major constituents of the lysosomal membrane. The two have closely related structures, with 37% sequence homology.{15782} They are both transmembrane glycoproteins that are localized primarily in lysosomes and late endosomes. Newly synthesized molecules are mostly transported from the trans-Golgi network directly to endosomes and then to lysosomes. A second pathway involves the LAMPs being delivered from the Golgi to the cell surface, and then along the endocytic pathway to the lysosomes. A minor pathway involves transport via the plasma membrane.{15783} Upon stimulation, a rapid translocation of intracellular LAMPs to the cell membrane is dependent on a carboxyl-terminal tyrosine based motif (YXXI).{15845} If there is a disturbance in this spacing, lysosome localization of LAMP1 is abolished and the mutant protein then cycles between the membrane and the endosome.{15783} This stimulation has also been shown to have an associated release of histamine, leukotriene C4 and prostaglandin D2, which shows that LAMP1 and LAMP2 are activation markers for normal mast cells.{15845} They have also been linked to the inflammatory response in that they promote adhesion of human peripheral blood mononuclear cells (PBMC) to vascular endothelium and therefore possibly adhesion of PBMC to the site of inflammation.{15784}
Brand:CaymanSKU:10011443 - 25 µgAvailable on backorder
Antigen: rat liver lysosomal membrane preparations · Host: mouse, clone Ly1C6 · Isotype: IgG1 · Cross-reactivity: (+) rat and hamster LAMP1 · Applications: WB, IP, and ICC
Brand:CaymanSKU:10011443- 25 µgAvailable on backorder
Antigen: purified preparation of mouse liver lysosomal membranes · Host: rat, clone GL2A7 · Cross Reactivity: (+) mouse and rabbit LAMP2 · Applications: IP and ICC · Isotype: IgG1
Brand:CaymanSKU:10011444- 100 µg Lysosome associated membrane protein 1 (LAMP1) and LAMP2 are major constituents of the lysosomal membrane. The two have closley related structures, with 37% sequence homology.{15782} They are both transmembrane glycoproteins that are localized primarily in lysosomes and late endosomes. Newly synthesized molecules are mostly transported from the trans-Golgi network directly to endosomes and then to lysosomes. A second pathway involves the LAMPs being delivered from the Golgi to the cell surface, and then along the endocytic pathway to the lysosomes. A minor pathway involves transport via the plasma membrane.{15783} LAMP2 has also been detected at the plasma membrane of cells, as well as in cells that secrete lysosomal hydrolases. A study in the developmental expression patterns of membrane LAMP2 transcripts indicate a possible involvement of this protein in cell-cell or cell-extracellular matrix interaction, and appear to reflect tissue and cell type specific roles of lysosomes during morphogenesis.{15803} Upon stimulation, a rapid translocation of intracellular LAMPs to the cell membrane is dependent on a carboxyl-terminal tyrosine based motif (YXXI).{15845} This stimulation has also been shown to have an associated release of histamine, leukotriene C4 and prostaglandin D2, which shows that LAMP1 and LAMP2 are activation markers for normal mast cells.{15845} They have also been linked to the inflammatory response in that they promote adhesion of human peripheral blood mononuclear cells (PBMC) to vascular endothelium, and therefore possibly the adhesion of PBMC to the site of inflammation.{15784} LAMP2 has also been shown to be critical for autophagy, in conversion of early autophagic vacuoles to vacuoles which rapidly degrade their content.{15804}
Brand:CaymanSKU:10011444 - 100 µgAvailable on backorder
Antigen: purified preparation of mouse liver lysosomal membranes · Host: rat, clone GL2A7 · Cross Reactivity: (+) mouse and rabbit LAMP2 · Applications: IP and ICC · Isotype: IgG1
Brand:CaymanSKU:10011444- 100 µgAvailable on backorder
Antigen: purified preparation of mouse liver lysosomal membranes · Host: rat, clone GL2A7 · Cross Reactivity: (+) mouse and rabbit LAMP2 · Applications: IP and ICC · Isotype: IgG1
Brand:CaymanSKU:10011444- 25 µg Lysosome associated membrane protein 1 (LAMP1) and LAMP2 are major constituents of the lysosomal membrane. The two have closley related structures, with 37% sequence homology.{15782} They are both transmembrane glycoproteins that are localized primarily in lysosomes and late endosomes. Newly synthesized molecules are mostly transported from the trans-Golgi network directly to endosomes and then to lysosomes. A second pathway involves the LAMPs being delivered from the Golgi to the cell surface, and then along the endocytic pathway to the lysosomes. A minor pathway involves transport via the plasma membrane.{15783} LAMP2 has also been detected at the plasma membrane of cells, as well as in cells that secrete lysosomal hydrolases. A study in the developmental expression patterns of membrane LAMP2 transcripts indicate a possible involvement of this protein in cell-cell or cell-extracellular matrix interaction, and appear to reflect tissue and cell type specific roles of lysosomes during morphogenesis.{15803} Upon stimulation, a rapid translocation of intracellular LAMPs to the cell membrane is dependent on a carboxyl-terminal tyrosine based motif (YXXI).{15845} This stimulation has also been shown to have an associated release of histamine, leukotriene C4 and prostaglandin D2, which shows that LAMP1 and LAMP2 are activation markers for normal mast cells.{15845} They have also been linked to the inflammatory response in that they promote adhesion of human peripheral blood mononuclear cells (PBMC) to vascular endothelium, and therefore possibly the adhesion of PBMC to the site of inflammation.{15784} LAMP2 has also been shown to be critical for autophagy, in conversion of early autophagic vacuoles to vacuoles which rapidly degrade their content.{15804}
Brand:CaymanSKU:10011444 - 25 µgAvailable on backorder
Antigen: purified preparation of mouse liver lysosomal membranes · Host: rat, clone GL2A7 · Cross Reactivity: (+) mouse and rabbit LAMP2 · Applications: IP and ICC · Isotype: IgG1
Brand:CaymanSKU:10011444- 25 µgAvailable on backorder
Lanicemine is a non-selective, voltage-dependent NMDA channel blocker (IC50 = 4-7 µM) that binds to sites within the channel pore with a Ki value of 0.56-2.1 µM.{27755} Compared to ketamine (Item No. 11630), lanicemine exhibits a lower propensity to be trapped within the NMDA channel (86% versus 54% trapping) following removal and reapplication of glutamate.{27755} It has been examined for its potential to produce antidepressant effects without adverse psychotomimetic activity.{27755,27756}
Brand:CaymanSKU:9002129 - 10 mgAvailable on backorder
Lanicemine is a non-selective, voltage-dependent NMDA channel blocker (IC50 = 4-7 µM) that binds to sites within the channel pore with a Ki value of 0.56-2.1 µM.{27755} Compared to ketamine (Item No. 11630), lanicemine exhibits a lower propensity to be trapped within the NMDA channel (86% versus 54% trapping) following removal and reapplication of glutamate.{27755} It has been examined for its potential to produce antidepressant effects without adverse psychotomimetic activity.{27755,27756}
Brand:CaymanSKU:9002129 - 25 mgAvailable on backorder
Lanicemine is a non-selective, voltage-dependent NMDA channel blocker (IC50 = 4-7 µM) that binds to sites within the channel pore with a Ki value of 0.56-2.1 µM.{27755} Compared to ketamine (Item No. 11630), lanicemine exhibits a lower propensity to be trapped within the NMDA channel (86% versus 54% trapping) following removal and reapplication of glutamate.{27755} It has been examined for its potential to produce antidepressant effects without adverse psychotomimetic activity.{27755,27756}
Brand:CaymanSKU:9002129 - 5 mgAvailable on backorder
Lanicemine is a non-selective, voltage-dependent NMDA channel blocker (IC50 = 4-7 µM) that binds to sites within the channel pore with a Ki value of 0.56-2.1 µM.{27755} Compared to ketamine (Item No. 11630), lanicemine exhibits a lower propensity to be trapped within the NMDA channel (86% versus 54% trapping) following removal and reapplication of glutamate.{27755} It has been examined for its potential to produce antidepressant effects without adverse psychotomimetic activity.{27755,27756}
Brand:CaymanSKU:9002129 - 50 mgAvailable on backorder
Lanifibranor is an agonist of peroxisome proliferator-activated receptors (PPARs) with EC50 values of 1,537, 866, and 206 nM for human recombinant PPARα, PPARβ, and PPARγ, respectively, for transactivation activity.{42553} It increases β-oxidation in Huh-7 and C2C12 cells when used at concentrations of 1 and 3 µM, respectively, and increases the expression of the PPARγ target genes adipocyte protein 2 (aP2) and adiponectin in adipocytes. Lanifibranor reduces plasma glucose and triglyceride levels in a db/db mouse model of type 2 diabetes when administered at doses of 10 and 30 mg/kg for five days. It also increases plasma adiponectin levels and decreases collagen deposition in a carbon tetrachloride-induced mouse model of non-alcoholic steatohepatitis (NASH).
Brand:CaymanSKU:25572 - 10 mgAvailable on backorder
Lanifibranor is an agonist of peroxisome proliferator-activated receptors (PPARs) with EC50 values of 1,537, 866, and 206 nM for human recombinant PPARα, PPARβ, and PPARγ, respectively, for transactivation activity.{42553} It increases β-oxidation in Huh-7 and C2C12 cells when used at concentrations of 1 and 3 µM, respectively, and increases the expression of the PPARγ target genes adipocyte protein 2 (aP2) and adiponectin in adipocytes. Lanifibranor reduces plasma glucose and triglyceride levels in a db/db mouse model of type 2 diabetes when administered at doses of 10 and 30 mg/kg for five days. It also increases plasma adiponectin levels and decreases collagen deposition in a carbon tetrachloride-induced mouse model of non-alcoholic steatohepatitis (NASH).
Brand:CaymanSKU:25572 - 25 mgAvailable on backorder
Lanifibranor is an agonist of peroxisome proliferator-activated receptors (PPARs) with EC50 values of 1,537, 866, and 206 nM for human recombinant PPARα, PPARβ, and PPARγ, respectively, for transactivation activity.{42553} It increases β-oxidation in Huh-7 and C2C12 cells when used at concentrations of 1 and 3 µM, respectively, and increases the expression of the PPARγ target genes adipocyte protein 2 (aP2) and adiponectin in adipocytes. Lanifibranor reduces plasma glucose and triglyceride levels in a db/db mouse model of type 2 diabetes when administered at doses of 10 and 30 mg/kg for five days. It also increases plasma adiponectin levels and decreases collagen deposition in a carbon tetrachloride-induced mouse model of non-alcoholic steatohepatitis (NASH).
Brand:CaymanSKU:25572 - 5 mgAvailable on backorder
Lanifibranor is an agonist of peroxisome proliferator-activated receptors (PPARs) with EC50 values of 1,537, 866, and 206 nM for human recombinant PPARα, PPARβ, and PPARγ, respectively, for transactivation activity.{42553} It increases β-oxidation in Huh-7 and C2C12 cells when used at concentrations of 1 and 3 µM, respectively, and increases the expression of the PPARγ target genes adipocyte protein 2 (aP2) and adiponectin in adipocytes. Lanifibranor reduces plasma glucose and triglyceride levels in a db/db mouse model of type 2 diabetes when administered at doses of 10 and 30 mg/kg for five days. It also increases plasma adiponectin levels and decreases collagen deposition in a carbon tetrachloride-induced mouse model of non-alcoholic steatohepatitis (NASH).
Brand:CaymanSKU:25572 - 50 mgAvailable on backorder
Lanosterol is a naturally-occurring sterol and biosynthetic precursor of several animal, fungal, and protozoan steroids, including cholesterol and ergosterol.{15099,26100,25587} Defects in the processing of lanosterol contribute to a wide variety of disorders, including the formation of cataracts.{26100,31446} Similarly, certain fungicides act by blocking lanosterol processing by fungi.{30322,23407}
Brand:CaymanSKU:-Available on backorder
Lanosterol is a naturally-occurring sterol and biosynthetic precursor of several animal, fungal, and protozoan steroids, including cholesterol and ergosterol.{15099,26100,25587} Defects in the processing of lanosterol contribute to a wide variety of disorders, including the formation of cataracts.{26100,31446} Similarly, certain fungicides act by blocking lanosterol processing by fungi.{30322,23407}
Brand:CaymanSKU:-Available on backorder
Lanosterol is a naturally-occurring sterol and biosynthetic precursor of several animal, fungal, and protozoan steroids, including cholesterol and ergosterol.{15099,26100,25587} Defects in the processing of lanosterol contribute to a wide variety of disorders, including the formation of cataracts.{26100,31446} Similarly, certain fungicides act by blocking lanosterol processing by fungi.{30322,23407}
Brand:CaymanSKU:-Available on backorder
Lanosterol is a naturally-occurring sterol and biosynthetic precursor of several animal, fungal, and protozoan steroids, including cholesterol and ergosterol.{15099,26100,25587} Defects in the processing of lanosterol contribute to a wide variety of disorders, including the formation of cataracts.{26100,31446} Similarly, certain fungicides act by blocking lanosterol processing by fungi.{30322,23407}
Brand:CaymanSKU:-Available on backorder
Lanreotide is a peptide analog of somatostatin that binds to somatostatin receptors (SSTRs) with a higher affinity for the somatostatin subgroup 2 receptors SST2, SST3, and SST5 (IC50s = 0.5-1.8, 43-107, and 5.6-32 nM, respectively) than for the subgroup 1 receptors, SST1 and SST4 (IC50s = 500-2,330 and 66-2,100 nM, respectively).{36315} Lanreotide (100 nM) inhibits the release of growth hormone from patient-derived pituitary adenoma cells in vitro.{36316} It also inhibits tumor growth in human small cell lung cancer (SCLC) mouse xenograft models when administered at a dose of 250 µg, twice daily.{36317} Formulations containing lanreotide have been used in the treatment of acromegaly and neuroendocrine tumors.
Brand:CaymanSKU:24084 - 1 mgAvailable on backorder
Lanreotide is a peptide analog of somatostatin that binds to somatostatin receptors (SSTRs) with a higher affinity for the somatostatin subgroup 2 receptors SST2, SST3, and SST5 (IC50s = 0.5-1.8, 43-107, and 5.6-32 nM, respectively) than for the subgroup 1 receptors, SST1 and SST4 (IC50s = 500-2,330 and 66-2,100 nM, respectively).{36315} Lanreotide (100 nM) inhibits the release of growth hormone from patient-derived pituitary adenoma cells in vitro.{36316} It also inhibits tumor growth in human small cell lung cancer (SCLC) mouse xenograft models when administered at a dose of 250 µg, twice daily.{36317} Formulations containing lanreotide have been used in the treatment of acromegaly and neuroendocrine tumors.
Brand:CaymanSKU:24084 - 10 mgAvailable on backorder
Lanreotide is a peptide analog of somatostatin that binds to somatostatin receptors (SSTRs) with a higher affinity for the somatostatin subgroup 2 receptors SST2, SST3, and SST5 (IC50s = 0.5-1.8, 43-107, and 5.6-32 nM, respectively) than for the subgroup 1 receptors, SST1 and SST4 (IC50s = 500-2,330 and 66-2,100 nM, respectively).{36315} Lanreotide (100 nM) inhibits the release of growth hormone from patient-derived pituitary adenoma cells in vitro.{36316} It also inhibits tumor growth in human small cell lung cancer (SCLC) mouse xenograft models when administered at a dose of 250 µg, twice daily.{36317} Formulations containing lanreotide have been used in the treatment of acromegaly and neuroendocrine tumors.
Brand:CaymanSKU:24084 - 5 mgAvailable on backorder
Lansoprazole is a proton pump inhibitor that inhibits the H+/K+-ATPase.{43057} It inhibits K+ and H+ accumulation in gastric microsomes in a concentration-dependent manner (IC50s = 6.3 and 7.0 µM, respectively) and inhibits H+/K+-ATPase activity by approximately 60% when used at a concentration of 10 µM. Lansoprazole inhibits the H+/K+-ATPase in parietal cells, thus inhibiting gastric acid secretion and increasing intragastric pH.{18250} It is a substituted benzimidazole that binds covalently to proton pumps, providing complete and prolonged inhibition of acid secretion.{18256,18258} Formulations containing lansoprazole have been used as a proton pump inhibitor and in combination with antibiotics in the treatment of H. pylori infections and duodenal ulcer disease.
Brand:CaymanSKU:- Lansoprazole is a proton pump inhibitor that inhibits the H+/K+-ATPase.{43057} It inhibits K+ and H+ accumulation in gastric microsomes in a concentration-dependent manner (IC50s = 6.3 and 7.0 µM, respectively) and inhibits H+/K+-ATPase activity by approximately 60% when used at a concentration of 10 µM. Lansoprazole inhibits the H+/K+-ATPase in parietal cells, thus inhibiting gastric acid secretion and increasing intragastric pH.{18250} It is a substituted benzimidazole that binds covalently to proton pumps, providing complete and prolonged inhibition of acid secretion.{18256,18258} Formulations containing lansoprazole have been used as a proton pump inhibitor and in combination with antibiotics in the treatment of H. pylori infections and duodenal ulcer disease.
Brand:CaymanSKU:- Lansoprazole is a proton pump inhibitor that inhibits the H+/K+-ATPase.{43057} It inhibits K+ and H+ accumulation in gastric microsomes in a concentration-dependent manner (IC50s = 6.3 and 7.0 µM, respectively) and inhibits H+/K+-ATPase activity by approximately 60% when used at a concentration of 10 µM. Lansoprazole inhibits the H+/K+-ATPase in parietal cells, thus inhibiting gastric acid secretion and increasing intragastric pH.{18250} It is a substituted benzimidazole that binds covalently to proton pumps, providing complete and prolonged inhibition of acid secretion.{18256,18258} Formulations containing lansoprazole have been used as a proton pump inhibitor and in combination with antibiotics in the treatment of H. pylori infections and duodenal ulcer disease.
Brand:CaymanSKU:- Lansoprazole is a proton pump inhibitor that inhibits the H+/K+-ATPase.{43057} It inhibits K+ and H+ accumulation in gastric microsomes in a concentration-dependent manner (IC50s = 6.3 and 7.0 µM, respectively) and inhibits H+/K+-ATPase activity by approximately 60% when used at a concentration of 10 µM. Lansoprazole inhibits the H+/K+-ATPase in parietal cells, thus inhibiting gastric acid secretion and increasing intragastric pH.{18250} It is a substituted benzimidazole that binds covalently to proton pumps, providing complete and prolonged inhibition of acid secretion.{18256,18258} Formulations containing lansoprazole have been used as a proton pump inhibitor and in combination with antibiotics in the treatment of H. pylori infections and duodenal ulcer disease.
Brand:CaymanSKU:-
Lansoprazole sulfone is a phase I metabolite of lansoprazole (Item Nos. 13627 | 21967 | 18235).{18257} Lansoprazole is a proton pump inhibitor that inactivates the hydrogen/potassium-stimulated ATPase pumps in parietal cells, thus inhibiting gastric acid secretion and increasing intragastric pH.{18250} Lansoprazole is metabolized by the cytochrome P450 (CYP) isoform CYP3A4 to form lansoprazole sulfone.{18257}
Brand:CaymanSKU:22569 -Out of stock
Lansoprazole sulfone is a phase I metabolite of lansoprazole (Item Nos. 13627 | 21967 | 18235).{18257} Lansoprazole is a proton pump inhibitor that inactivates the hydrogen/potassium-stimulated ATPase pumps in parietal cells, thus inhibiting gastric acid secretion and increasing intragastric pH.{18250} Lansoprazole is metabolized by the cytochrome P450 (CYP) isoform CYP3A4 to form lansoprazole sulfone.{18257}
Brand:CaymanSKU:22569 -Out of stock
Lansoprazole sulfone is a phase I metabolite of lansoprazole (Item Nos. 13627 | 21967 | 18235).{18257} Lansoprazole is a proton pump inhibitor that inactivates the hydrogen/potassium-stimulated ATPase pumps in parietal cells, thus inhibiting gastric acid secretion and increasing intragastric pH.{18250} Lansoprazole is metabolized by the cytochrome P450 (CYP) isoform CYP3A4 to form lansoprazole sulfone.{18257}
Brand:CaymanSKU:22569 -Out of stock
Lansoprazole-d4 is intended for use as an internal standard for the quantification of lansoprazole (Item No. 13627) by GC- or LC-MS. Lansoprazole is a proton pump inhibitor that inhibits the H+/K+-ATPase.{43057} It inhibits K+ and H+ accumulation in gastric microsomes in a concentration-dependent manner (IC50s = 6.3 and 7 µM, respectively) and inhibits H+/K+-ATPase activity by approximately 60% when used at a concentration of 10 µM. Lansoprazole inhibits the H+/K+-ATPase in parietal cells, thus inhibiting gastric acid secretion and increasing intragastric pH.{18250} It is a substituted benzimidazole that binds covalently to proton pumps, providing complete and prolonged inhibition of acid secretion.{18256,18258} Formulations containing lansoprazole have been used as a proton pump inhibitor and in combination with antibiotics in the treatment of H. pylori infections and duodenal ulcer disease.
Brand:CaymanSKU:25227 - 1 mgAvailable on backorder
Lansoprazole-d4 is intended for use as an internal standard for the quantification of lansoprazole (Item No. 13627) by GC- or LC-MS. Lansoprazole is a proton pump inhibitor that inhibits the H+/K+-ATPase.{43057} It inhibits K+ and H+ accumulation in gastric microsomes in a concentration-dependent manner (IC50s = 6.3 and 7 µM, respectively) and inhibits H+/K+-ATPase activity by approximately 60% when used at a concentration of 10 µM. Lansoprazole inhibits the H+/K+-ATPase in parietal cells, thus inhibiting gastric acid secretion and increasing intragastric pH.{18250} It is a substituted benzimidazole that binds covalently to proton pumps, providing complete and prolonged inhibition of acid secretion.{18256,18258} Formulations containing lansoprazole have been used as a proton pump inhibitor and in combination with antibiotics in the treatment of H. pylori infections and duodenal ulcer disease.
Brand:CaymanSKU:25227 - 500 µgAvailable on backorder
Lapachol is a naphthoquinone originally isolated from T. impetiginosa and has diverse biological activities.{53616,53618,53617,53619,53620} It is larvicidal against T. canis when used at a concentration of 2 mg/ml.{53616} Lapachol (10 and 100 µM) inhibits topoisomerase I and topoisomerase II activities, as well as induces apoptosis and DNA damage in C6 rat glioma cells.{53618} It reduces B. atrox venom phospholipase A2 (PLA2) activity in a turbidimetric assay when used at a concentration of 10 µg/ml.{53617} Lapachol (3 and 10 mg/kg) reduces synovial leukocyte infiltration and joint destruction in a mouse model of collagen-induced arthritis.{53619} It also reduces carrageenan-induced paw edema and abscess formation in rats.{53620}
Brand:CaymanSKU:30190 - 1 gAvailable on backorder
Lapachol is a naphthoquinone originally isolated from T. impetiginosa and has diverse biological activities.{53616,53618,53617,53619,53620} It is larvicidal against T. canis when used at a concentration of 2 mg/ml.{53616} Lapachol (10 and 100 µM) inhibits topoisomerase I and topoisomerase II activities, as well as induces apoptosis and DNA damage in C6 rat glioma cells.{53618} It reduces B. atrox venom phospholipase A2 (PLA2) activity in a turbidimetric assay when used at a concentration of 10 µg/ml.{53617} Lapachol (3 and 10 mg/kg) reduces synovial leukocyte infiltration and joint destruction in a mouse model of collagen-induced arthritis.{53619} It also reduces carrageenan-induced paw edema and abscess formation in rats.{53620}
Brand:CaymanSKU:30190 - 100 mgAvailable on backorder
Lapachol is a naphthoquinone originally isolated from T. impetiginosa and has diverse biological activities.{53616,53618,53617,53619,53620} It is larvicidal against T. canis when used at a concentration of 2 mg/ml.{53616} Lapachol (10 and 100 µM) inhibits topoisomerase I and topoisomerase II activities, as well as induces apoptosis and DNA damage in C6 rat glioma cells.{53618} It reduces B. atrox venom phospholipase A2 (PLA2) activity in a turbidimetric assay when used at a concentration of 10 µg/ml.{53617} Lapachol (3 and 10 mg/kg) reduces synovial leukocyte infiltration and joint destruction in a mouse model of collagen-induced arthritis.{53619} It also reduces carrageenan-induced paw edema and abscess formation in rats.{53620}
Brand:CaymanSKU:30190 - 250 mgAvailable on backorder
Lapachol is a naphthoquinone originally isolated from T. impetiginosa and has diverse biological activities.{53616,53618,53617,53619,53620} It is larvicidal against T. canis when used at a concentration of 2 mg/ml.{53616} Lapachol (10 and 100 µM) inhibits topoisomerase I and topoisomerase II activities, as well as induces apoptosis and DNA damage in C6 rat glioma cells.{53618} It reduces B. atrox venom phospholipase A2 (PLA2) activity in a turbidimetric assay when used at a concentration of 10 µg/ml.{53617} Lapachol (3 and 10 mg/kg) reduces synovial leukocyte infiltration and joint destruction in a mouse model of collagen-induced arthritis.{53619} It also reduces carrageenan-induced paw edema and abscess formation in rats.{53620}
Brand:CaymanSKU:30190 - 500 mgAvailable on backorder
Lapatinib is a dual inhibitor of the EGF receptor (EGFR) and ErbB2 (IC50s = 19 and 3 nM, respectively).{24151} It inhibits the growth of EGFR-overexpressing A431 skin cancer and ErbB2-overexpressing SK-BR-3 breast cancer cells (IC50s = 0.14 and 0.124 μM, respectively). Lapatinib also inhibits the growth of ErbB2-amplified OD19 esophageal and NCI-N87 gastric cancer cells (IC50s = 0.09 and 0.01 μM, respectively) as well as several types of gastric cancer cells in which ErbB2 is not amplified (IC50s = 0.35-8.58 μM).{36874} It induces apoptosis in NCI-N87 and OD19 cells when used at a concentration of 1 μM. Lapatinib (50 mg/kg) reduces tumor growth in a BT474 breast cancer mouse xenograft model.{36875} It also reduces tumor growth in an NCI-N87 mouse xenograft model when administered at a dose of 100 mg/kg and induces tumor regression when used in combination with trastuzumab.{36874} Formulations containing lapatinib have been used in combination with other therapeutics in the treatment of HER2-overexpressing breast cancer.
Brand:CaymanSKU:11493 - 10 mgAvailable on backorder
Lapatinib is a dual inhibitor of the EGF receptor (EGFR) and ErbB2 (IC50s = 19 and 3 nM, respectively).{24151} It inhibits the growth of EGFR-overexpressing A431 skin cancer and ErbB2-overexpressing SK-BR-3 breast cancer cells (IC50s = 0.14 and 0.124 μM, respectively). Lapatinib also inhibits the growth of ErbB2-amplified OD19 esophageal and NCI-N87 gastric cancer cells (IC50s = 0.09 and 0.01 μM, respectively) as well as several types of gastric cancer cells in which ErbB2 is not amplified (IC50s = 0.35-8.58 μM).{36874} It induces apoptosis in NCI-N87 and OD19 cells when used at a concentration of 1 μM. Lapatinib (50 mg/kg) reduces tumor growth in a BT474 breast cancer mouse xenograft model.{36875} It also reduces tumor growth in an NCI-N87 mouse xenograft model when administered at a dose of 100 mg/kg and induces tumor regression when used in combination with trastuzumab.{36874} Formulations containing lapatinib have been used in combination with other therapeutics in the treatment of HER2-overexpressing breast cancer.
Brand:CaymanSKU:11493 - 100 mgAvailable on backorder