Cayman
Showing 26101–26250 of 45550 results
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JWH 369 is a synthetic cannabinoid (CB) that potently activates the central CB1 and peripheral CB2 receptors (Ki = 7.9 and 5.2 nM, respectively).{20067} While the physiological actions of JWH 369 have not been examined, similar naphthoyl pyrroles are effective in the mouse spontaneous activity and tail flick assays.{20067} This product is intended for forensic and research purposes.
Brand:CaymanSKU:10828 - 1 mgAvailable on backorder
JWH 369 is a synthetic cannabinoid (CB) that potently activates the central CB1 and peripheral CB2 receptors (Ki = 7.9 and 5.2 nM, respectively).{20067} While the physiological actions of JWH 369 have not been examined, similar naphthoyl pyrroles are effective in the mouse spontaneous activity and tail flick assays.{20067} This product is intended for forensic and research purposes.
Brand:CaymanSKU:10828 - 10 mgAvailable on backorder
JWH 369 is a synthetic cannabinoid (CB) that potently activates the central CB1 and peripheral CB2 receptors (Ki = 7.9 and 5.2 nM, respectively).{20067} While the physiological actions of JWH 369 have not been examined, similar naphthoyl pyrroles are effective in the mouse spontaneous activity and tail flick assays.{20067} This product is intended for forensic and research purposes.
Brand:CaymanSKU:10828 - 25 mgAvailable on backorder
JWH 369 is a synthetic cannabinoid (CB) that potently activates the central CB1 and peripheral CB2 receptors (Ki = 7.9 and 5.2 nM, respectively).{20067} While the physiological actions of JWH 369 have not been examined, similar naphthoyl pyrroles are effective in the mouse spontaneous activity and tail flick assays.{20067} This product is intended for forensic and research purposes.
Brand:CaymanSKU:10828 - 5 mgAvailable on backorder
Several aminoalkylindole cannabinoids (CB), including JWH 018 and JWH 073, have been detected in herbal blends.{19508,18620} JWH 370 is a (1-naphthoyl)pyrrole analog of JWH 018 that potently activates both CB1 and CB2 receptors (Ki values of 5.6 and 4.0 nM, respectively).{20067} Its biological properties have not been evaluated. This compound is intended for forensic and research applications.
Brand:CaymanSKU:10827 - 1 mgAvailable on backorder
Several aminoalkylindole cannabinoids (CB), including JWH 018 and JWH 073, have been detected in herbal blends.{19508,18620} JWH 370 is a (1-naphthoyl)pyrrole analog of JWH 018 that potently activates both CB1 and CB2 receptors (Ki values of 5.6 and 4.0 nM, respectively).{20067} Its biological properties have not been evaluated. This compound is intended for forensic and research applications.
Brand:CaymanSKU:10827 - 10 mgAvailable on backorder
Several aminoalkylindole cannabinoids (CB), including JWH 018 and JWH 073, have been detected in herbal blends.{19508,18620} JWH 370 is a (1-naphthoyl)pyrrole analog of JWH 018 that potently activates both CB1 and CB2 receptors (Ki values of 5.6 and 4.0 nM, respectively).{20067} Its biological properties have not been evaluated. This compound is intended for forensic and research applications.
Brand:CaymanSKU:10827 - 25 mgAvailable on backorder
Several aminoalkylindole cannabinoids (CB), including JWH 018 and JWH 073, have been detected in herbal blends.{19508,18620} JWH 370 is a (1-naphthoyl)pyrrole analog of JWH 018 that potently activates both CB1 and CB2 receptors (Ki values of 5.6 and 4.0 nM, respectively).{20067} Its biological properties have not been evaluated. This compound is intended for forensic and research applications.
Brand:CaymanSKU:10827 - 5 mgAvailable on backorder
JWH 387 is an analgesic cannabimimetic from the naphthoylindole family that acts as a potent cannabinoid (CB) agonist at both the central CB1 and peripheral CB2 receptors with Ki values of 1.2 and 1.1 nM, respectively.{22143} This product is intended for research and forensic purposes.
Brand:CaymanSKU:12020 - 1 mgAvailable on backorder
JWH 387 is an analgesic cannabimimetic from the naphthoylindole family that acts as a potent cannabinoid (CB) agonist at both the central CB1 and peripheral CB2 receptors with Ki values of 1.2 and 1.1 nM, respectively.{22143} This product is intended for research and forensic purposes.
Brand:CaymanSKU:12020 - 10 mgAvailable on backorder
JWH 387 is an analgesic cannabimimetic from the naphthoylindole family that acts as a potent cannabinoid (CB) agonist at both the central CB1 and peripheral CB2 receptors with Ki values of 1.2 and 1.1 nM, respectively.{22143} This product is intended for research and forensic purposes.
Brand:CaymanSKU:12020 - 5 mgAvailable on backorder
JWH 398 (exempt preparation) (Item No. 15686) is an analytical reference standard categorized as a synthetic cannabinoid.{18699} JWH 398 is regulated as a Schedule I compound in the United States. JWH 398 (exempt preparation) (Item No. 15686) is provided as a DEA exempt preparation. This product is intended for research and forensic applications.
Brand:CaymanSKU:-
JWH 398 is a synthetic cannabinoid (CB) that acts as an agonist at both the central cannabinoid (CB1) receptor and the peripheral cannabinoid (CB2) receptor (Kis = 2.3 and 2.8 nM, respectively).{18699} It has been detected as an additive of herbal mixtures.{19508} JWH 398 2-chloronaphthyl isomer differs structurally from JWH 398 by having the chloro group attached to the naphthyl rings at the 2, rather than the 4, position. The biological and toxicological properties of this compound have not been characterized. This product is intended for forensic purposes.
Brand:CaymanSKU:9001023 - 1 mgAvailable on backorder
JWH 398 is a synthetic cannabinoid (CB) that acts as an agonist at both the central cannabinoid (CB1) receptor and the peripheral cannabinoid (CB2) receptor (Kis = 2.3 and 2.8 nM, respectively).{18699} It has been detected as an additive of herbal mixtures.{19508} JWH 398 2-chloronaphthyl isomer differs structurally from JWH 398 by having the chloro group attached to the naphthyl rings at the 2, rather than the 4, position. The biological and toxicological properties of this compound have not been characterized. This product is intended for forensic purposes.
Brand:CaymanSKU:9001023 - 10 mgAvailable on backorder
JWH 398 is a synthetic cannabinoid (CB) that acts as an agonist at both the central cannabinoid (CB1) receptor and the peripheral cannabinoid (CB2) receptor (Kis = 2.3 and 2.8 nM, respectively).{18699} It has been detected as an additive of herbal mixtures.{19508} JWH 398 2-chloronaphthyl isomer differs structurally from JWH 398 by having the chloro group attached to the naphthyl rings at the 2, rather than the 4, position. The biological and toxicological properties of this compound have not been characterized. This product is intended for forensic purposes.
Brand:CaymanSKU:9001023 - 5 mgAvailable on backorder
JWH 398 is a synthetic cannabinoid (CB) that acts as an agonist at both the central CB1 receptor and the peripheral CB2 receptor (Ki = 2.3 and 2.8 nM, respectively).{18699} It has been detected as an additive of herbal mixtures.{19508} JWH 398 5-chloronaphthyl isomer differs structurally from JWH 398 by having the chloro group attached to the naphthyl rings at the 5, rather than the 4, position. The biological and toxicological properties of this compound have not been characterized. This product is intended for forensic purposes.
Brand:CaymanSKU:9001025 - 1 mgAvailable on backorder
JWH 398 is a synthetic cannabinoid (CB) that acts as an agonist at both the central CB1 receptor and the peripheral CB2 receptor (Ki = 2.3 and 2.8 nM, respectively).{18699} It has been detected as an additive of herbal mixtures.{19508} JWH 398 5-chloronaphthyl isomer differs structurally from JWH 398 by having the chloro group attached to the naphthyl rings at the 5, rather than the 4, position. The biological and toxicological properties of this compound have not been characterized. This product is intended for forensic purposes.
Brand:CaymanSKU:9001025 - 10 mgAvailable on backorder
JWH 398 is a synthetic cannabinoid (CB) that acts as an agonist at both the central CB1 receptor and the peripheral CB2 receptor (Ki = 2.3 and 2.8 nM, respectively).{18699} It has been detected as an additive of herbal mixtures.{19508} JWH 398 5-chloronaphthyl isomer differs structurally from JWH 398 by having the chloro group attached to the naphthyl rings at the 5, rather than the 4, position. The biological and toxicological properties of this compound have not been characterized. This product is intended for forensic purposes.
Brand:CaymanSKU:9001025 - 5 mgAvailable on backorder
JWH 398 is a synthetic cannabinoid (CB) that acts as an agonist at both the central cannabinoid (CB1) receptor and the peripheral cannabinoid (CB2) receptor (Kis = 2.3 and 2.8 nM, respectively).{18699} It has been detected as an additive of herbal mixtures.{19508} JWH 398 7-chloronaphthyl isomer differs structurally from JWH 398 by having the chloro group attached to the naphthyl rings at the 7, rather than the 4, position. The biological and toxicological properties of this compound have not been characterized. This product is intended for forensic purposes.
Brand:CaymanSKU:9001027 - 1 mgAvailable on backorder
JWH 398 is a synthetic cannabinoid (CB) that acts as an agonist at both the central cannabinoid (CB1) receptor and the peripheral cannabinoid (CB2) receptor (Kis = 2.3 and 2.8 nM, respectively).{18699} It has been detected as an additive of herbal mixtures.{19508} JWH 398 7-chloronaphthyl isomer differs structurally from JWH 398 by having the chloro group attached to the naphthyl rings at the 7, rather than the 4, position. The biological and toxicological properties of this compound have not been characterized. This product is intended for forensic purposes.
Brand:CaymanSKU:9001027 - 10 mgAvailable on backorder
JWH 398 is a synthetic cannabinoid (CB) that acts as an agonist at both the central cannabinoid (CB1) receptor and the peripheral cannabinoid (CB2) receptor (Kis = 2.3 and 2.8 nM, respectively).{18699} It has been detected as an additive of herbal mixtures.{19508} JWH 398 7-chloronaphthyl isomer differs structurally from JWH 398 by having the chloro group attached to the naphthyl rings at the 7, rather than the 4, position. The biological and toxicological properties of this compound have not been characterized. This product is intended for forensic purposes.
Brand:CaymanSKU:9001027 - 5 mgAvailable on backorder
JWH 398 is a synthetic cannabinoid (CB) that acts as an agonist at both the central CB1 receptor and the peripheral CB2 receptor (Kis = 2.3 and 2.8 nM, respectively).{18699} It has been detected as an additive of herbal mixtures.{19508} JWH 398 8-chloronaphthyl isomer differs structurally from JWH 398 by having chlorine positioned on the naphthyl rings at the 8, rather than the 4, position. The biological and toxicological properties of this compound have not been characterized. This product is intended for forensic purposes.
Brand:CaymanSKU:9001028 - 1 mgAvailable on backorder
JWH 398 is a synthetic cannabinoid (CB) that acts as an agonist at both the central CB1 receptor and the peripheral CB2 receptor (Kis = 2.3 and 2.8 nM, respectively).{18699} It has been detected as an additive of herbal mixtures.{19508} JWH 398 8-chloronaphthyl isomer differs structurally from JWH 398 by having chlorine positioned on the naphthyl rings at the 8, rather than the 4, position. The biological and toxicological properties of this compound have not been characterized. This product is intended for forensic purposes.
Brand:CaymanSKU:9001028 - 10 mgAvailable on backorder
JWH 398 is a synthetic cannabinoid (CB) that acts as an agonist at both the central CB1 receptor and the peripheral CB2 receptor (Kis = 2.3 and 2.8 nM, respectively).{18699} It has been detected as an additive of herbal mixtures.{19508} JWH 398 8-chloronaphthyl isomer differs structurally from JWH 398 by having chlorine positioned on the naphthyl rings at the 8, rather than the 4, position. The biological and toxicological properties of this compound have not been characterized. This product is intended for forensic purposes.
Brand:CaymanSKU:9001028 - 5 mgAvailable on backorder
JWH 398 (Item No. 13636) is a synthetic cannabinoid (CB) that activates both central CB1 and peripheral CB2 receptors (Ki = 2.3 and 2.8 nM, respectively).{18699} It has been reported to be an adulterant of herbal products.{19508,19506} JWH 398 N-(4-hydroxypentyl) metabolite is an expected phase I metabolite of JWH 398 (Item No. 13636), detectable in serum and urine. While similar hydroxylated phase I metabolites of synthetic CBs retain activity, the physiological properties of this compound have yet to be determined.{20952,20953} This product is intended for research and forensic applications.
Brand:CaymanSKU:10943 - 1 mgAvailable on backorder
JWH 398 (Item No. 13636) is a synthetic cannabinoid (CB) that activates both central CB1 and peripheral CB2 receptors (Ki = 2.3 and 2.8 nM, respectively).{18699} It has been reported to be an adulterant of herbal products.{19508,19506} JWH 398 N-(4-hydroxypentyl) metabolite is an expected phase I metabolite of JWH 398 (Item No. 13636), detectable in serum and urine. While similar hydroxylated phase I metabolites of synthetic CBs retain activity, the physiological properties of this compound have yet to be determined.{20952,20953} This product is intended for research and forensic applications.
Brand:CaymanSKU:10943 - 10 mgAvailable on backorder
JWH 398 (Item No. 13636) is a synthetic cannabinoid (CB) that activates both central CB1 and peripheral CB2 receptors (Ki = 2.3 and 2.8 nM, respectively).{18699} It has been reported to be an adulterant of herbal products.{19508,19506} JWH 398 N-(4-hydroxypentyl) metabolite is an expected phase I metabolite of JWH 398 (Item No. 13636), detectable in serum and urine. While similar hydroxylated phase I metabolites of synthetic CBs retain activity, the physiological properties of this compound have yet to be determined.{20952,20953} This product is intended for research and forensic applications.
Brand:CaymanSKU:10943 - 5 mgAvailable on backorder
JWH 398 is a synthetic cannabinoid (CB) that activates both CB1 and CB2 receptors (Ki values of 2.3 and 2.8 nM, respectively).{18699} It has been reported to be an adulterant of herbal products.{19508,19506} JWH 398 N-(5-hydroxypentyl) metabolite is a potential metabolite of JWH 398. Metabolism of structurally similar compounds leads to monohydroxylation of the N-alkyl chain, detectable in urine.{18291}
Brand:CaymanSKU:9000770 - 1 mgAvailable on backorder
JWH 398 is a synthetic cannabinoid (CB) that activates both CB1 and CB2 receptors (Ki values of 2.3 and 2.8 nM, respectively).{18699} It has been reported to be an adulterant of herbal products.{19508,19506} JWH 398 N-(5-hydroxypentyl) metabolite is a potential metabolite of JWH 398. Metabolism of structurally similar compounds leads to monohydroxylation of the N-alkyl chain, detectable in urine.{18291}
Brand:CaymanSKU:9000770 - 10 mgAvailable on backorder
JWH 398 is a synthetic cannabinoid (CB) that activates both CB1 and CB2 receptors (Ki values of 2.3 and 2.8 nM, respectively).{18699} It has been reported to be an adulterant of herbal products.{19508,19506} JWH 398 N-(5-hydroxypentyl) metabolite is a potential metabolite of JWH 398. Metabolism of structurally similar compounds leads to monohydroxylation of the N-alkyl chain, detectable in urine.{18291}
Brand:CaymanSKU:9000770 - 5 mgAvailable on backorder
JWH 398 (Item No. 13636) is a synthetic cannabinoid (CB) that acts as an agonist at both the central CB1 receptor and the peripheral CB2 receptor (Kis = 2.3 and 2.8 nM, respectively).{18699} It has been detected as an additive of herbal mixtures.{19508} JWH 398 N-pentanoic acid metabolite is an expected phase I metabolite of JWH 398. The biological and toxicological properties of this compound have not been characterized. This product is intended for forensic and research purposes.
Brand:CaymanSKU:10942 - 1 mgAvailable on backorder
JWH 398 (Item No. 13636) is a synthetic cannabinoid (CB) that acts as an agonist at both the central CB1 receptor and the peripheral CB2 receptor (Kis = 2.3 and 2.8 nM, respectively).{18699} It has been detected as an additive of herbal mixtures.{19508} JWH 398 N-pentanoic acid metabolite is an expected phase I metabolite of JWH 398. The biological and toxicological properties of this compound have not been characterized. This product is intended for forensic and research purposes.
Brand:CaymanSKU:10942 - 10 mgAvailable on backorder
JWH 398 (Item No. 13636) is a synthetic cannabinoid (CB) that acts as an agonist at both the central CB1 receptor and the peripheral CB2 receptor (Kis = 2.3 and 2.8 nM, respectively).{18699} It has been detected as an additive of herbal mixtures.{19508} JWH 398 N-pentanoic acid metabolite is an expected phase I metabolite of JWH 398. The biological and toxicological properties of this compound have not been characterized. This product is intended for forensic and research purposes.
Brand:CaymanSKU:10942 - 5 mgAvailable on backorder
JWH 412 is a positional isomer of AM2201 (Item No. 10707) that was identified in the ‘herbal mixture’ XoXo.{20995} The substitution of hydrogen against fluorine in the 4-position of the naphthyl moiety enhances the binding affinity to the central cannabinoid (CB1) receptor compared to the unsubstituted JWH 018.{20995} JWH 412 demonstrates Ki values of 7.2 and 3.2 nM at CB1 and peripheral CB2 receptors, respectively.{22143} This product is intended for research and forensic purposes.
Brand:CaymanSKU:11971 - 1 mgAvailable on backorder
JWH 412 is a positional isomer of AM2201 (Item No. 10707) that was identified in the ‘herbal mixture’ XoXo.{20995} The substitution of hydrogen against fluorine in the 4-position of the naphthyl moiety enhances the binding affinity to the central cannabinoid (CB1) receptor compared to the unsubstituted JWH 018.{20995} JWH 412 demonstrates Ki values of 7.2 and 3.2 nM at CB1 and peripheral CB2 receptors, respectively.{22143} This product is intended for research and forensic purposes.
Brand:CaymanSKU:11971 - 10 mgAvailable on backorder
JWH 412 is a positional isomer of AM2201 (Item No. 10707) that was identified in the ‘herbal mixture’ XoXo.{20995} The substitution of hydrogen against fluorine in the 4-position of the naphthyl moiety enhances the binding affinity to the central cannabinoid (CB1) receptor compared to the unsubstituted JWH 018.{20995} JWH 412 demonstrates Ki values of 7.2 and 3.2 nM at CB1 and peripheral CB2 receptors, respectively.{22143} This product is intended for research and forensic purposes.
Brand:CaymanSKU:11971 - 5 mgAvailable on backorder
JWH 018 is a synthetic cannabinoid (CB) that potently activates the central CB1 and peripheral CB2 receptors (Ki = 9.0 and 2.94 nM, respectively).{16797} This cannabimimetic compound has frequently been found in herbal blends. {18620,18621,18618} JWH 424 is an 8-bromonaphthyl derivative of JWH 018 which shows a reduced selectivity for CB1 over CB2 (Ki = 20.9 and 5.4 nM, respectively). The properties of this compound in vivo are not known. This product is intended for forensic and research applications.
Brand:CaymanSKU:9001203 - 10 mgAvailable on backorder
JWH 018 is a synthetic cannabinoid (CB) that potently activates the central CB1 and peripheral CB2 receptors (Ki = 9.0 and 2.94 nM, respectively).{16797} This cannabimimetic compound has frequently been found in herbal blends. {18620,18621,18618} JWH 424 is an 8-bromonaphthyl derivative of JWH 018 which shows a reduced selectivity for CB1 over CB2 (Ki = 20.9 and 5.4 nM, respectively). The properties of this compound in vivo are not known. This product is intended for forensic and research applications.
Brand:CaymanSKU:9001203 - 25 mgAvailable on backorder
JWH 018 is a synthetic cannabinoid (CB) that potently activates the central CB1 and peripheral CB2 receptors (Ki = 9.0 and 2.94 nM, respectively).{16797} This cannabimimetic compound has frequently been found in herbal blends. {18620,18621,18618} JWH 424 is an 8-bromonaphthyl derivative of JWH 018 which shows a reduced selectivity for CB1 over CB2 (Ki = 20.9 and 5.4 nM, respectively). The properties of this compound in vivo are not known. This product is intended for forensic and research applications.
Brand:CaymanSKU:9001203 - 5 mgAvailable on backorder
JX-401 is a potent, reversible inhibitor of the p38α isoform of MAP kinase (IC50 = 32 nM).{27632} It does not inhibit the p38γ isoform.{27632} JX-401 is effective in mammalian cells, as it blocks the differentiation of myoblasts into myotubes.{27632}
Brand:CaymanSKU:-Out of stock
JX-401 is a potent, reversible inhibitor of the p38α isoform of MAP kinase (IC50 = 32 nM).{27632} It does not inhibit the p38γ isoform.{27632} JX-401 is effective in mammalian cells, as it blocks the differentiation of myoblasts into myotubes.{27632}
Brand:CaymanSKU:-Out of stock
JX-401 is a potent, reversible inhibitor of the p38α isoform of MAP kinase (IC50 = 32 nM).{27632} It does not inhibit the p38γ isoform.{27632} JX-401 is effective in mammalian cells, as it blocks the differentiation of myoblasts into myotubes.{27632}
Brand:CaymanSKU:-Out of stock
JX-401 is a potent, reversible inhibitor of the p38α isoform of MAP kinase (IC50 = 32 nM).{27632} It does not inhibit the p38γ isoform.{27632} JX-401 is effective in mammalian cells, as it blocks the differentiation of myoblasts into myotubes.{27632}
Brand:CaymanSKU:-Out of stock
JYL1421 is an antagonist of transient receptor potential vanilloid 1 (TRPV1).{48180} It inhibits calcium uptake induced by capsaicin (Item Nos. 92350 | 10010743) in CHO cells expressing rat TRPV1 (EC50 = 9.2 nM). JYL1421 inhibits capsaicin-induced release of the neuropeptides somatostatin, substance P (Item No. 24035), and calcitonin gene-related peptide (CGRP) from isolated rat trachea (IC50s = 227-491 nM).{48181} It inhibits capsaicin-induced hypothermia and hypotension in rats when administered at doses of 2 and 0.4 mg/kg, respectively. JYL1421 (2 mg/kg) also reduces the number of wiping movements induced by ocular administration of capsaicin in rats. Unlike several other TRPV1 antagonists, JYL1421 does not induce hyperthermia in rats when administered at doses ranging from 1.02 to 32.77 μmol/kg.{48182}
Brand:CaymanSKU:20458 -Available on backorder
JYL1421 is an antagonist of transient receptor potential vanilloid 1 (TRPV1).{48180} It inhibits calcium uptake induced by capsaicin (Item Nos. 92350 | 10010743) in CHO cells expressing rat TRPV1 (EC50 = 9.2 nM). JYL1421 inhibits capsaicin-induced release of the neuropeptides somatostatin, substance P (Item No. 24035), and calcitonin gene-related peptide (CGRP) from isolated rat trachea (IC50s = 227-491 nM).{48181} It inhibits capsaicin-induced hypothermia and hypotension in rats when administered at doses of 2 and 0.4 mg/kg, respectively. JYL1421 (2 mg/kg) also reduces the number of wiping movements induced by ocular administration of capsaicin in rats. Unlike several other TRPV1 antagonists, JYL1421 does not induce hyperthermia in rats when administered at doses ranging from 1.02 to 32.77 μmol/kg.{48182}
Brand:CaymanSKU:20458 -Available on backorder
JYL1421 is an antagonist of transient receptor potential vanilloid 1 (TRPV1).{48180} It inhibits calcium uptake induced by capsaicin (Item Nos. 92350 | 10010743) in CHO cells expressing rat TRPV1 (EC50 = 9.2 nM). JYL1421 inhibits capsaicin-induced release of the neuropeptides somatostatin, substance P (Item No. 24035), and calcitonin gene-related peptide (CGRP) from isolated rat trachea (IC50s = 227-491 nM).{48181} It inhibits capsaicin-induced hypothermia and hypotension in rats when administered at doses of 2 and 0.4 mg/kg, respectively. JYL1421 (2 mg/kg) also reduces the number of wiping movements induced by ocular administration of capsaicin in rats. Unlike several other TRPV1 antagonists, JYL1421 does not induce hyperthermia in rats when administered at doses ranging from 1.02 to 32.77 μmol/kg.{48182}
Brand:CaymanSKU:20458 -Available on backorder
JYL1421 is an antagonist of transient receptor potential vanilloid 1 (TRPV1).{48180} It inhibits calcium uptake induced by capsaicin (Item Nos. 92350 | 10010743) in CHO cells expressing rat TRPV1 (EC50 = 9.2 nM). JYL1421 inhibits capsaicin-induced release of the neuropeptides somatostatin, substance P (Item No. 24035), and calcitonin gene-related peptide (CGRP) from isolated rat trachea (IC50s = 227-491 nM).{48181} It inhibits capsaicin-induced hypothermia and hypotension in rats when administered at doses of 2 and 0.4 mg/kg, respectively. JYL1421 (2 mg/kg) also reduces the number of wiping movements induced by ocular administration of capsaicin in rats. Unlike several other TRPV1 antagonists, JYL1421 does not induce hyperthermia in rats when administered at doses ranging from 1.02 to 32.77 μmol/kg.{48182}
Brand:CaymanSKU:20458 -Available on backorder
Endocannabinoids such as 2-arachidonoyl glycerol (2-AG) and arachidonoyl ethanolamide (AEA) are biologically active lipids that are involved in a number of synaptic processes including activation of cannabinoid receptors. Monoacylglycerol lipase (MAGL) is a serine hydrolase responsible for the hydrolysis of 2-AG to arachidonic acid and glycerol, thus terminating its biological function. JZL 184 is a potent and selective inhibitor of monoacylglycerol lipase (MAGL) that displays IC50 values of 8 nM and 4 µM for inhibition of MAGL and fatty acid amide hydrolase in mouse brain membranes, respectively.{16639} When administered to mice at 16 mg/kg, intraperitoneally, JZL 184 reduces MAGL activity by 85%, elevates brain 2-AG levels by 8-fold, and elicits analgesic activity in a variety of pain assays that qualitatively mimics direct central cannabinoid (CB1) agonists.{16639}
Brand:CaymanSKU:- Endocannabinoids such as 2-arachidonoyl glycerol (2-AG) and arachidonoyl ethanolamide (AEA) are biologically active lipids that are involved in a number of synaptic processes including activation of cannabinoid receptors. Monoacylglycerol lipase (MAGL) is a serine hydrolase responsible for the hydrolysis of 2-AG to arachidonic acid and glycerol, thus terminating its biological function. JZL 184 is a potent and selective inhibitor of monoacylglycerol lipase (MAGL) that displays IC50 values of 8 nM and 4 µM for inhibition of MAGL and fatty acid amide hydrolase in mouse brain membranes, respectively.{16639} When administered to mice at 16 mg/kg, intraperitoneally, JZL 184 reduces MAGL activity by 85%, elevates brain 2-AG levels by 8-fold, and elicits analgesic activity in a variety of pain assays that qualitatively mimics direct central cannabinoid (CB1) agonists.{16639}
Brand:CaymanSKU:- Endocannabinoids such as 2-arachidonoyl glycerol (2-AG) and arachidonoyl ethanolamide (AEA) are biologically active lipids that are involved in a number of synaptic processes including activation of cannabinoid receptors. Monoacylglycerol lipase (MAGL) is a serine hydrolase responsible for the hydrolysis of 2-AG to arachidonic acid and glycerol, thus terminating its biological function. JZL 184 is a potent and selective inhibitor of monoacylglycerol lipase (MAGL) that displays IC50 values of 8 nM and 4 µM for inhibition of MAGL and fatty acid amide hydrolase in mouse brain membranes, respectively.{16639} When administered to mice at 16 mg/kg, intraperitoneally, JZL 184 reduces MAGL activity by 85%, elevates brain 2-AG levels by 8-fold, and elicits analgesic activity in a variety of pain assays that qualitatively mimics direct central cannabinoid (CB1) agonists.{16639}
Brand:CaymanSKU:- Endocannabinoids such as 2-arachidonoyl glycerol (2-AG) and arachidonoyl ethanolamide (AEA) are biologically active lipids that are involved in a number of synaptic processes including activation of cannabinoid receptors. Monoacylglycerol lipase (MAGL) is a serine hydrolase responsible for the hydrolysis of 2-AG to arachidonic acid and glycerol, thus terminating its biological function. JZL 184 is a potent and selective inhibitor of monoacylglycerol lipase (MAGL) that displays IC50 values of 8 nM and 4 µM for inhibition of MAGL and fatty acid amide hydrolase in mouse brain membranes, respectively.{16639} When administered to mice at 16 mg/kg, intraperitoneally, JZL 184 reduces MAGL activity by 85%, elevates brain 2-AG levels by 8-fold, and elicits analgesic activity in a variety of pain assays that qualitatively mimics direct central cannabinoid (CB1) agonists.{16639}
Brand:CaymanSKU:-
Fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) mediate the hydrolysis of the endocannabinoids arachidonoyl ethanolamide (AEA) and 2-arachidonoylglycerol (2-AG), respectively. JZL 195 is a potent inhibitor of both FAAH and MAGL (IC50s = 2 and 4 nM, respectively).{17764} It poorly inhibits neuropathy target esterase and ABHD6 and does not inhibit other brain serine hydrolases. JZL 195 displays time-dependent inhibition of FAAH and MAGL in vivo, consistent with a covalent mechanism of activation.{17764} The in vivo inhibitory actions of JZL 195 against FAAH and MAGL are comparable to those of the selective inhibitors PF-3845 (Item No. 13279) and JZL 184 (Item No. 13158), respectively.{17764} Through its inhibitory actions, JZL 195 simultaneously augments brain levels of AEA and 2-AG, producing antinociceptive, cataleptic, and hypomotility effects like those produced by direct CB1 agonists.{17764}
Brand:CaymanSKU:- Fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) mediate the hydrolysis of the endocannabinoids arachidonoyl ethanolamide (AEA) and 2-arachidonoylglycerol (2-AG), respectively. JZL 195 is a potent inhibitor of both FAAH and MAGL (IC50s = 2 and 4 nM, respectively).{17764} It poorly inhibits neuropathy target esterase and ABHD6 and does not inhibit other brain serine hydrolases. JZL 195 displays time-dependent inhibition of FAAH and MAGL in vivo, consistent with a covalent mechanism of activation.{17764} The in vivo inhibitory actions of JZL 195 against FAAH and MAGL are comparable to those of the selective inhibitors PF-3845 (Item No. 13279) and JZL 184 (Item No. 13158), respectively.{17764} Through its inhibitory actions, JZL 195 simultaneously augments brain levels of AEA and 2-AG, producing antinociceptive, cataleptic, and hypomotility effects like those produced by direct CB1 agonists.{17764}
Brand:CaymanSKU:- Fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) mediate the hydrolysis of the endocannabinoids arachidonoyl ethanolamide (AEA) and 2-arachidonoylglycerol (2-AG), respectively. JZL 195 is a potent inhibitor of both FAAH and MAGL (IC50s = 2 and 4 nM, respectively).{17764} It poorly inhibits neuropathy target esterase and ABHD6 and does not inhibit other brain serine hydrolases. JZL 195 displays time-dependent inhibition of FAAH and MAGL in vivo, consistent with a covalent mechanism of activation.{17764} The in vivo inhibitory actions of JZL 195 against FAAH and MAGL are comparable to those of the selective inhibitors PF-3845 (Item No. 13279) and JZL 184 (Item No. 13158), respectively.{17764} Through its inhibitory actions, JZL 195 simultaneously augments brain levels of AEA and 2-AG, producing antinociceptive, cataleptic, and hypomotility effects like those produced by direct CB1 agonists.{17764}
Brand:CaymanSKU:- Fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) mediate the hydrolysis of the endocannabinoids arachidonoyl ethanolamide (AEA) and 2-arachidonoylglycerol (2-AG), respectively. JZL 195 is a potent inhibitor of both FAAH and MAGL (IC50s = 2 and 4 nM, respectively).{17764} It poorly inhibits neuropathy target esterase and ABHD6 and does not inhibit other brain serine hydrolases. JZL 195 displays time-dependent inhibition of FAAH and MAGL in vivo, consistent with a covalent mechanism of activation.{17764} The in vivo inhibitory actions of JZL 195 against FAAH and MAGL are comparable to those of the selective inhibitors PF-3845 (Item No. 13279) and JZL 184 (Item No. 13158), respectively.{17764} Through its inhibitory actions, JZL 195 simultaneously augments brain levels of AEA and 2-AG, producing antinociceptive, cataleptic, and hypomotility effects like those produced by direct CB1 agonists.{17764}
Brand:CaymanSKU:-
Brand:CaymanSKU:700307 - 20 nmolAvailable on backorder
K-41 is a monoglycoside polyether fungal metabolite originally isolated from S. hygroscopicus that has antibiotic and antiparasitic activities.{49629,29573} It is active against B. subtilis, B. anthracis, S. aureus, S. pyogenes, S. pneumoniae, C. diphtheriae, and M. tuberculosis (MICs = 3.13, 1.56, 1.56, 0.78, 0.39, 0.78, and 3.13 µg/ml, respectively).{49629} K-41 is active against the K1 drug-resistant and FCR3 drug-susceptible P. falciparum strains (IC50s = 8.5 and 31 nM, respectively).{29573} In vivo, K-41 has antiparasitic activity in mouse models of P. berghei and P. yoelii infection (ED50s = 1.9 and 7.0 mg/kg, respectively).
Brand:CaymanSKU:29573 - 1 mgAvailable on backorder
K-Ras(G12C) inhibitor 12 irreversibly binds to the oncogenic mutant K-Ras(G12C), blocking K-Ras(G12C) interactions.{30952} K-Ras is a small GTPase that cycles between a GTP-bound active state and a GDP-bound inactive state to turn on downstream Raf kinases to drive cell growth. A G12C mutation in K-Ras blocks GTP hydrolysis, activates K-Ras, and promotes carcinogenesis. This compound has been used to decrease viability and increase apoptosis in several lung cancer cell lines containing G12C mutations (EC50 = 0.32 µM in H1792 cells).{30952}
Brand:CaymanSKU:20118 -Available on backorder
K-Ras(G12C) inhibitor 12 irreversibly binds to the oncogenic mutant K-Ras(G12C), blocking K-Ras(G12C) interactions.{30952} K-Ras is a small GTPase that cycles between a GTP-bound active state and a GDP-bound inactive state to turn on downstream Raf kinases to drive cell growth. A G12C mutation in K-Ras blocks GTP hydrolysis, activates K-Ras, and promotes carcinogenesis. This compound has been used to decrease viability and increase apoptosis in several lung cancer cell lines containing G12C mutations (EC50 = 0.32 µM in H1792 cells).{30952}
Brand:CaymanSKU:20118 -Available on backorder
K-Ras(G12C) inhibitor 12 irreversibly binds to the oncogenic mutant K-Ras(G12C), blocking K-Ras(G12C) interactions.{30952} K-Ras is a small GTPase that cycles between a GTP-bound active state and a GDP-bound inactive state to turn on downstream Raf kinases to drive cell growth. A G12C mutation in K-Ras blocks GTP hydrolysis, activates K-Ras, and promotes carcinogenesis. This compound has been used to decrease viability and increase apoptosis in several lung cancer cell lines containing G12C mutations (EC50 = 0.32 µM in H1792 cells).{30952}
Brand:CaymanSKU:20118 -Available on backorder
K-Ras(G12C) inhibitor 12 irreversibly binds to the oncogenic mutant K-Ras(G12C), blocking K-Ras(G12C) interactions.{30952} K-Ras is a small GTPase that cycles between a GTP-bound active state and a GDP-bound inactive state to turn on downstream Raf kinases to drive cell growth. A G12C mutation in K-Ras blocks GTP hydrolysis, activates K-Ras, and promotes carcinogenesis. This compound has been used to decrease viability and increase apoptosis in several lung cancer cell lines containing G12C mutations (EC50 = 0.32 µM in H1792 cells).{30952}
Brand:CaymanSKU:20118 -Available on backorder
K-Ras(G12C) inhibitor 9 is an irreversible, allosteric inhibitor of the K-Ras(G12C) mutant that causes 100% modification of the protein when used at 10 µM for 24 hours in vitro.{30952} K-Ras is a small GTPase that cycles between a GTP-bound active state and a GDP-bound inactive state to turn on downstream Raf kinases to drive cell growth. A G12C mutation in K-Ras blocks GTP hydrolysis, activates K-Ras, and promotes carcinogenesis.{31182,31183} Similar K-Ras(G12C) inhibitors significantly reduce GTP affinity relative to GDP, decrease Raf binding, and lower cell viability while increasing apoptosis.{30952}
Brand:CaymanSKU:-Available on backorder
K-Ras(G12C) inhibitor 9 is an irreversible, allosteric inhibitor of the K-Ras(G12C) mutant that causes 100% modification of the protein when used at 10 µM for 24 hours in vitro.{30952} K-Ras is a small GTPase that cycles between a GTP-bound active state and a GDP-bound inactive state to turn on downstream Raf kinases to drive cell growth. A G12C mutation in K-Ras blocks GTP hydrolysis, activates K-Ras, and promotes carcinogenesis.{31182,31183} Similar K-Ras(G12C) inhibitors significantly reduce GTP affinity relative to GDP, decrease Raf binding, and lower cell viability while increasing apoptosis.{30952}
Brand:CaymanSKU:-Available on backorder
K-Ras(G12C) inhibitor 9 is an irreversible, allosteric inhibitor of the K-Ras(G12C) mutant that causes 100% modification of the protein when used at 10 µM for 24 hours in vitro.{30952} K-Ras is a small GTPase that cycles between a GTP-bound active state and a GDP-bound inactive state to turn on downstream Raf kinases to drive cell growth. A G12C mutation in K-Ras blocks GTP hydrolysis, activates K-Ras, and promotes carcinogenesis.{31182,31183} Similar K-Ras(G12C) inhibitors significantly reduce GTP affinity relative to GDP, decrease Raf binding, and lower cell viability while increasing apoptosis.{30952}
Brand:CaymanSKU:-Available on backorder
K-Ras(G12C) inhibitor 9 is an irreversible, allosteric inhibitor of the K-Ras(G12C) mutant that causes 100% modification of the protein when used at 10 µM for 24 hours in vitro.{30952} K-Ras is a small GTPase that cycles between a GTP-bound active state and a GDP-bound inactive state to turn on downstream Raf kinases to drive cell growth. A G12C mutation in K-Ras blocks GTP hydrolysis, activates K-Ras, and promotes carcinogenesis.{31182,31183} Similar K-Ras(G12C) inhibitors significantly reduce GTP affinity relative to GDP, decrease Raf binding, and lower cell viability while increasing apoptosis.{30952}
Brand:CaymanSKU:-Available on backorder
K-TMZ is a DNA alkylating agent.{42788} It increases the concentration of O6-methylated deoxyguanosine in U87 glioblastoma multiforme (GBM) cells in a concentration-dependent manner. K-TMZ reduces cell viability of GBM cell lines lacking (IC50s = 18-44 μM) or expressing O6-methylguanine DNA methyltransferase (MGMT; IC50s = 115-240 μM). K-TMZ can cross the blood-brain barrier and increases survival in a Br23c mouse xenograft model of GBM when administered at a dose of 14.9 mg/kg.
Brand:CaymanSKU:27022 - 1 mgAvailable on backorder
K-TMZ is a DNA alkylating agent.{42788} It increases the concentration of O6-methylated deoxyguanosine in U87 glioblastoma multiforme (GBM) cells in a concentration-dependent manner. K-TMZ reduces cell viability of GBM cell lines lacking (IC50s = 18-44 μM) or expressing O6-methylguanine DNA methyltransferase (MGMT; IC50s = 115-240 μM). K-TMZ can cross the blood-brain barrier and increases survival in a Br23c mouse xenograft model of GBM when administered at a dose of 14.9 mg/kg.
Brand:CaymanSKU:27022 - 10 mgAvailable on backorder
K-TMZ is a DNA alkylating agent.{42788} It increases the concentration of O6-methylated deoxyguanosine in U87 glioblastoma multiforme (GBM) cells in a concentration-dependent manner. K-TMZ reduces cell viability of GBM cell lines lacking (IC50s = 18-44 μM) or expressing O6-methylguanine DNA methyltransferase (MGMT; IC50s = 115-240 μM). K-TMZ can cross the blood-brain barrier and increases survival in a Br23c mouse xenograft model of GBM when administered at a dose of 14.9 mg/kg.
Brand:CaymanSKU:27022 - 5 mgAvailable on backorder
Activation of bone morphogenetic protein (BMP) type I receptors, also known as activin receptor-like kinases (ALK1-7), leads to the assembly of SMAD complexes, which translocate to the nucleus to induce transcriptional activation important for normal development and tissue repair.{9612} K02288 is a 2-aminopyridine-based inhibitor of ALK1 and ALK2 with IC50 values of 1.8 and 1.1 nM, respectively.{23387} It is less selective for ALK3, 4, 5, and 6 subtypes and the type II BMP receptor ActRIIA, demonstrating IC50 values of 34.4, 302, 321, 6.4, and 220 nM, respectively.{23387} K02288 can prevent BMP4-induced SMAD1/5/8 pathway activation in vitro (IC50 = 100 nM) without affecting TGF-β signaling. Furthermore, at 8-10 µM, K02288 has been used to induce the dorsalization of zebrafish embryos. Through specific inhibition of BMP signaling, this compound can be used to research stem cell biology and disease models of musculoskeletal dysplasia and cancer.{23387}
Brand:CaymanSKU:-Out of stock
Activation of bone morphogenetic protein (BMP) type I receptors, also known as activin receptor-like kinases (ALK1-7), leads to the assembly of SMAD complexes, which translocate to the nucleus to induce transcriptional activation important for normal development and tissue repair.{9612} K02288 is a 2-aminopyridine-based inhibitor of ALK1 and ALK2 with IC50 values of 1.8 and 1.1 nM, respectively.{23387} It is less selective for ALK3, 4, 5, and 6 subtypes and the type II BMP receptor ActRIIA, demonstrating IC50 values of 34.4, 302, 321, 6.4, and 220 nM, respectively.{23387} K02288 can prevent BMP4-induced SMAD1/5/8 pathway activation in vitro (IC50 = 100 nM) without affecting TGF-β signaling. Furthermore, at 8-10 µM, K02288 has been used to induce the dorsalization of zebrafish embryos. Through specific inhibition of BMP signaling, this compound can be used to research stem cell biology and disease models of musculoskeletal dysplasia and cancer.{23387}
Brand:CaymanSKU:-Out of stock
Activation of bone morphogenetic protein (BMP) type I receptors, also known as activin receptor-like kinases (ALK1-7), leads to the assembly of SMAD complexes, which translocate to the nucleus to induce transcriptional activation important for normal development and tissue repair.{9612} K02288 is a 2-aminopyridine-based inhibitor of ALK1 and ALK2 with IC50 values of 1.8 and 1.1 nM, respectively.{23387} It is less selective for ALK3, 4, 5, and 6 subtypes and the type II BMP receptor ActRIIA, demonstrating IC50 values of 34.4, 302, 321, 6.4, and 220 nM, respectively.{23387} K02288 can prevent BMP4-induced SMAD1/5/8 pathway activation in vitro (IC50 = 100 nM) without affecting TGF-β signaling. Furthermore, at 8-10 µM, K02288 has been used to induce the dorsalization of zebrafish embryos. Through specific inhibition of BMP signaling, this compound can be used to research stem cell biology and disease models of musculoskeletal dysplasia and cancer.{23387}
Brand:CaymanSKU:-Out of stock
Activation of bone morphogenetic protein (BMP) type I receptors, also known as activin receptor-like kinases (ALK1-7), leads to the assembly of SMAD complexes, which translocate to the nucleus to induce transcriptional activation important for normal development and tissue repair.{9612} K02288 is a 2-aminopyridine-based inhibitor of ALK1 and ALK2 with IC50 values of 1.8 and 1.1 nM, respectively.{23387} It is less selective for ALK3, 4, 5, and 6 subtypes and the type II BMP receptor ActRIIA, demonstrating IC50 values of 34.4, 302, 321, 6.4, and 220 nM, respectively.{23387} K02288 can prevent BMP4-induced SMAD1/5/8 pathway activation in vitro (IC50 = 100 nM) without affecting TGF-β signaling. Furthermore, at 8-10 µM, K02288 has been used to induce the dorsalization of zebrafish embryos. Through specific inhibition of BMP signaling, this compound can be used to research stem cell biology and disease models of musculoskeletal dysplasia and cancer.{23387}
Brand:CaymanSKU:-Out of stock
K145 is a selective inhibitor of sphingosine kinase 2 (SPHK2; Ki = 6.4 µM) with IC50 values of 4.3 and >10 µM for human recombinant SPHK2 and SPHK1, respectively.{41106} It inhibits SPHK2, but not SPHK1, activity in U937 cells when used at a concentration of 10 µM. In vivo, K145 (15 mg/kg, i.p.) inhibits tumor growth in a U937 mouse xenograft model. It also improves glucose tolerance and regulates gluconeogenesis by stimulating insulin-dependent Akt/FoxO1 signaling in a mouse model of insulin resistance induced by dexamethasone (Item No. 11015) when administered at a dose of 30 mg/kg.{41107}
Brand:CaymanSKU:11691 - 1 mgAvailable on backorder
K145 is a selective inhibitor of sphingosine kinase 2 (SPHK2; Ki = 6.4 µM) with IC50 values of 4.3 and >10 µM for human recombinant SPHK2 and SPHK1, respectively.{41106} It inhibits SPHK2, but not SPHK1, activity in U937 cells when used at a concentration of 10 µM. In vivo, K145 (15 mg/kg, i.p.) inhibits tumor growth in a U937 mouse xenograft model. It also improves glucose tolerance and regulates gluconeogenesis by stimulating insulin-dependent Akt/FoxO1 signaling in a mouse model of insulin resistance induced by dexamethasone (Item No. 11015) when administered at a dose of 30 mg/kg.{41107}
Brand:CaymanSKU:11691 - 5 mgAvailable on backorder
K145 is a selective inhibitor of sphingosine kinase 2 (SPHK2; Ki = 6.4 µM) with IC50 values of 4.3 and >10 µM for human recombinant SPHK2 and SPHK1, respectively.{41106} It inhibits SPHK2, but not SPHK1, activity in U937 cells when used at a concentration of 10 µM. In vivo, K145 (15 mg/kg, i.p.) inhibits tumor growth in a U937 mouse xenograft model. It also improves glucose tolerance and regulates gluconeogenesis by stimulating insulin-dependent Akt/FoxO1 signaling in a mouse model of insulin resistance induced by dexamethasone (Item No. 11015) when administered at a dose of 30 mg/kg.{41107}
Brand:CaymanSKU:11691 - 500 µgAvailable on backorder
K22 is an antiviral agent.{59568} It inhibits the replication of severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoV), human coronavirus 229E (HCoV-229E), feline coronavirus (FCoV), and mouse hepatitis virus (MHV) in Vero cells when used at a concentration of 40 µM. K22 inhibits the formation of double membrane vesicles, a hallmark of coronavirus replication, and inhibits viral RNA synthesis in HCoV-229E-infected MRC-5 cells. It also reduces viral titers in cells infected with various Arteriviridae or Torovirinae viruses.{59569}
Brand:CaymanSKU:31578 - 1 mgAvailable on backorder
K22 is an antiviral agent.{59568} It inhibits the replication of severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoV), human coronavirus 229E (HCoV-229E), feline coronavirus (FCoV), and mouse hepatitis virus (MHV) in Vero cells when used at a concentration of 40 µM. K22 inhibits the formation of double membrane vesicles, a hallmark of coronavirus replication, and inhibits viral RNA synthesis in HCoV-229E-infected MRC-5 cells. It also reduces viral titers in cells infected with various Arteriviridae or Torovirinae viruses.{59569}
Brand:CaymanSKU:31578 - 10 mgAvailable on backorder
K22 is an antiviral agent.{59568} It inhibits the replication of severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoV), human coronavirus 229E (HCoV-229E), feline coronavirus (FCoV), and mouse hepatitis virus (MHV) in Vero cells when used at a concentration of 40 µM. K22 inhibits the formation of double membrane vesicles, a hallmark of coronavirus replication, and inhibits viral RNA synthesis in HCoV-229E-infected MRC-5 cells. It also reduces viral titers in cells infected with various Arteriviridae or Torovirinae viruses.{59569}
Brand:CaymanSKU:31578 - 25 mgAvailable on backorder
K22 is an antiviral agent.{59568} It inhibits the replication of severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoV), human coronavirus 229E (HCoV-229E), feline coronavirus (FCoV), and mouse hepatitis virus (MHV) in Vero cells when used at a concentration of 40 µM. K22 inhibits the formation of double membrane vesicles, a hallmark of coronavirus replication, and inhibits viral RNA synthesis in HCoV-229E-infected MRC-5 cells. It also reduces viral titers in cells infected with various Arteriviridae or Torovirinae viruses.{59569}
Brand:CaymanSKU:31578 - 5 mgAvailable on backorder
K252a is a staurosporine analog isolated from Nocardiopsis sp. soil fungi that inhibits protein kinase (PK) C, PKA, Ca2+/calmodulin-dependent kinase type II, and phosphorylase kinase with IC50 values of 470, 140, 270, and 1.7 nM, respectively.{21294,17276} Because it inhibits neurotrophin receptor tyrosine kinases, K252a at 100-500 nM has been used to suppress trophoblast proliferation and increase apoptosis associated with the disruption of mitochondrial functions in cultured choriocarcinoma cells.{21290} Recently, K252a has been shown to inhibit PRK1 (IC50 = 3.2 nM in vitro), a PKC-related kinase that phosphorylates histone H3 at threonine 11 and is involved in androgen-dependent gene expression.{21798}
Brand:CaymanSKU:11338 - 1 mgAvailable on backorder
K252a is a staurosporine analog isolated from Nocardiopsis sp. soil fungi that inhibits protein kinase (PK) C, PKA, Ca2+/calmodulin-dependent kinase type II, and phosphorylase kinase with IC50 values of 470, 140, 270, and 1.7 nM, respectively.{21294,17276} Because it inhibits neurotrophin receptor tyrosine kinases, K252a at 100-500 nM has been used to suppress trophoblast proliferation and increase apoptosis associated with the disruption of mitochondrial functions in cultured choriocarcinoma cells.{21290} Recently, K252a has been shown to inhibit PRK1 (IC50 = 3.2 nM in vitro), a PKC-related kinase that phosphorylates histone H3 at threonine 11 and is involved in androgen-dependent gene expression.{21798}
Brand:CaymanSKU:11338 - 5 mgAvailable on backorder