Cayman
Showing 25201–25350 of 45550 results
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Isocorydine is an aporphine alkaloid that has been found in A. squamosa that has vasodilatory and anticancer activities.{52447,52448,52449,52450,52451} It reduces the action potential duration and increases the effective refractory period in isolated canine Purkinje fibers when used at a concentration of 30 µM.{52448} Isocorydine induces relaxation of norepinephrine-precontracted isolated rabbit aortic strips with an EC50 value of 12.6 µM.{52449} It is cytotoxic to A549 lung cancer cells (IC50 = 197.7 µM), as well as Huh7, HepG2, SNU-449, and SNU-387 hepatic cancer cells (IC50s = 161.3, 148, 262.2, and 254.1 µg/ml, respectively).{52450,52451} Isocorydine, in combination with doxorubicin, reduces tumor growth in a Huh7 mouse xenograft model.{52451}
Brand:CaymanSKU:30101 - 5 mgAvailable on backorder
Isocorydine is an aporphine alkaloid that has been found in A. squamosa that has vasodilatory and anticancer activities.{52447,52448,52449,52450,52451} It reduces the action potential duration and increases the effective refractory period in isolated canine Purkinje fibers when used at a concentration of 30 µM.{52448} Isocorydine induces relaxation of norepinephrine-precontracted isolated rabbit aortic strips with an EC50 value of 12.6 µM.{52449} It is cytotoxic to A549 lung cancer cells (IC50 = 197.7 µM), as well as Huh7, HepG2, SNU-449, and SNU-387 hepatic cancer cells (IC50s = 161.3, 148, 262.2, and 254.1 µg/ml, respectively).{52450,52451} Isocorydine, in combination with doxorubicin, reduces tumor growth in a Huh7 mouse xenograft model.{52451}
Brand:CaymanSKU:30101 - 50 mgAvailable on backorder
Isocyclosporin A is an isomer of cyclosporin A (Item No. 12088) that forms upon acid hydrolysis or upon ionization during mass spectrometry (MS).{31935,31936} A method to differentiate the two isomers during MS has been described.{31935}
Brand:CaymanSKU:-Available on backorder
Isocyclosporin A is an isomer of cyclosporin A (Item No. 12088) that forms upon acid hydrolysis or upon ionization during mass spectrometry (MS).{31935,31936} A method to differentiate the two isomers during MS has been described.{31935}
Brand:CaymanSKU:-Available on backorder
Isodeoxycholic acid is a bile acid that is formed via epimerization of deoxycholic acid (DCA; Item Nos. 20756 | 18231) by intestinal bacteria.{54005} It has a greater critical micelle concentration than DCA, indicating reduced detergent activity, and is less active than DCA in inhibiting growth in a panel of seven gut commensal bacteria species. Isodeoxycholic acid (0.1%) inhibits spore germination induced by taurocholic acid (Item No. 16215) in several C. difficile strains, as well as decreases the cytotoxicity of C. difficile culture supernatants to Vero cells.{54006} Plasma levels of isodeoxycholic acid are decreased in a rat model of high-fat diet-induced obesity compared with rats fed a normal diet.{54007}
Brand:CaymanSKU:29890 - 1 mgAvailable on backorder
Isodeoxycholic acid is a bile acid that is formed via epimerization of deoxycholic acid (DCA; Item Nos. 20756 | 18231) by intestinal bacteria.{54005} It has a greater critical micelle concentration than DCA, indicating reduced detergent activity, and is less active than DCA in inhibiting growth in a panel of seven gut commensal bacteria species. Isodeoxycholic acid (0.1%) inhibits spore germination induced by taurocholic acid (Item No. 16215) in several C. difficile strains, as well as decreases the cytotoxicity of C. difficile culture supernatants to Vero cells.{54006} Plasma levels of isodeoxycholic acid are decreased in a rat model of high-fat diet-induced obesity compared with rats fed a normal diet.{54007}
Brand:CaymanSKU:29890 - 10 mgAvailable on backorder
Isodeoxycholic acid is a bile acid that is formed via epimerization of deoxycholic acid (DCA; Item Nos. 20756 | 18231) by intestinal bacteria.{54005} It has a greater critical micelle concentration than DCA, indicating reduced detergent activity, and is less active than DCA in inhibiting growth in a panel of seven gut commensal bacteria species. Isodeoxycholic acid (0.1%) inhibits spore germination induced by taurocholic acid (Item No. 16215) in several C. difficile strains, as well as decreases the cytotoxicity of C. difficile culture supernatants to Vero cells.{54006} Plasma levels of isodeoxycholic acid are decreased in a rat model of high-fat diet-induced obesity compared with rats fed a normal diet.{54007}
Brand:CaymanSKU:29890 - 5 mgAvailable on backorder
Isofagomine (D-tartrate) is a competitive inhibitor of human lysosomal β-glucosidase (Ki = 0.016-0.025 µM; IC50 = 0.06 µM).{22626} By interacting with the catalytic pocket of β-glucosidase it acts as a chemical chaperone that increases the amount of β-glucosidase by stabilizing and/or promoting the folding of the enzyme.{25308} Isofagomine (D-tartrate) has been shown to increase lysosomal β-glucosidase activity by 2- to 3-fold in mutant N370S Gaucher fibroblasts.{22626} This compound has been studied in the context of Gaucher disease, a lysosomal storage disorder resulting from substantial deficiency of β-glucosidase and recently identified as a parkinsonism risk factor.{25308}
Brand:CaymanSKU:- Isofagomine (D-tartrate) is a competitive inhibitor of human lysosomal β-glucosidase (Ki = 0.016-0.025 µM; IC50 = 0.06 µM).{22626} By interacting with the catalytic pocket of β-glucosidase it acts as a chemical chaperone that increases the amount of β-glucosidase by stabilizing and/or promoting the folding of the enzyme.{25308} Isofagomine (D-tartrate) has been shown to increase lysosomal β-glucosidase activity by 2- to 3-fold in mutant N370S Gaucher fibroblasts.{22626} This compound has been studied in the context of Gaucher disease, a lysosomal storage disorder resulting from substantial deficiency of β-glucosidase and recently identified as a parkinsonism risk factor.{25308}
Brand:CaymanSKU:- Isofagomine (D-tartrate) is a competitive inhibitor of human lysosomal β-glucosidase (Ki = 0.016-0.025 µM; IC50 = 0.06 µM).{22626} By interacting with the catalytic pocket of β-glucosidase it acts as a chemical chaperone that increases the amount of β-glucosidase by stabilizing and/or promoting the folding of the enzyme.{25308} Isofagomine (D-tartrate) has been shown to increase lysosomal β-glucosidase activity by 2- to 3-fold in mutant N370S Gaucher fibroblasts.{22626} This compound has been studied in the context of Gaucher disease, a lysosomal storage disorder resulting from substantial deficiency of β-glucosidase and recently identified as a parkinsonism risk factor.{25308}
Brand:CaymanSKU:-
Isoferulic acid is a cinnamic acid derivative that has antidiabetic activity.{40026,40027} It binds to and activates α1-adrenergic receptors (IC50 = 1.4 µM) to enhance secretion of β-endorphin (EC50 = 52.2 nM) and increase glucose use in vitro. Isoferulic acid increases glucose uptake and enhances glycogen synthesis in isolated soleus muscles from streptozocin-induced diabetic rats.{40025} In vivo, isoferulic acid induces a dose-dependent reduction in plasma glucose levels in streptozocin-induced diabetic rats. It also inhibits absorbance of intestinal maltase and sucrose via α-glucosidase in vitro (IC50s = 760 and 450 µM, respectively).{40028}
Brand:CaymanSKU:22715 -Out of stock
Isoferulic acid is a cinnamic acid derivative that has antidiabetic activity.{40026,40027} It binds to and activates α1-adrenergic receptors (IC50 = 1.4 µM) to enhance secretion of β-endorphin (EC50 = 52.2 nM) and increase glucose use in vitro. Isoferulic acid increases glucose uptake and enhances glycogen synthesis in isolated soleus muscles from streptozocin-induced diabetic rats.{40025} In vivo, isoferulic acid induces a dose-dependent reduction in plasma glucose levels in streptozocin-induced diabetic rats. It also inhibits absorbance of intestinal maltase and sucrose via α-glucosidase in vitro (IC50s = 760 and 450 µM, respectively).{40028}
Brand:CaymanSKU:22715 -Out of stock
Isoferulic acid is a cinnamic acid derivative that has antidiabetic activity.{40026,40027} It binds to and activates α1-adrenergic receptors (IC50 = 1.4 µM) to enhance secretion of β-endorphin (EC50 = 52.2 nM) and increase glucose use in vitro. Isoferulic acid increases glucose uptake and enhances glycogen synthesis in isolated soleus muscles from streptozocin-induced diabetic rats.{40025} In vivo, isoferulic acid induces a dose-dependent reduction in plasma glucose levels in streptozocin-induced diabetic rats. It also inhibits absorbance of intestinal maltase and sucrose via α-glucosidase in vitro (IC50s = 760 and 450 µM, respectively).{40028}
Brand:CaymanSKU:22715 -Out of stock
Isoferulic acid is a cinnamic acid derivative that has antidiabetic activity.{40026,40027} It binds to and activates α1-adrenergic receptors (IC50 = 1.4 µM) to enhance secretion of β-endorphin (EC50 = 52.2 nM) and increase glucose use in vitro. Isoferulic acid increases glucose uptake and enhances glycogen synthesis in isolated soleus muscles from streptozocin-induced diabetic rats.{40025} In vivo, isoferulic acid induces a dose-dependent reduction in plasma glucose levels in streptozocin-induced diabetic rats. It also inhibits absorbance of intestinal maltase and sucrose via α-glucosidase in vitro (IC50s = 760 and 450 µM, respectively).{40028}
Brand:CaymanSKU:22715 -Out of stock
Isoflurane is a halogenated ether with anesthetic properties.{37284} While the mechanism of isoflurane anesthesia is not fully understood, mice resistant to isoflurane anesthesia have an 86% decrease in gene expression for the GABAA receptor subunit β1 compared with isoflurane-sensitive mice, indicating that the GABAA receptor may be required for its anesthetic effect. In mice, isoflurane (1.5% for 4 hours) impairs spatial recognition memory in the spontaneous alternation test and Y-maze and increases levels of phosphorylated Jnk1/2 for at least 24 hours.{37283} Formulations containing isoflurane have been used as anesthetics.
Brand:CaymanSKU:23989 - 1 gAvailable on backorder
Isoflurane is a halogenated ether with anesthetic properties.{37284} While the mechanism of isoflurane anesthesia is not fully understood, mice resistant to isoflurane anesthesia have an 86% decrease in gene expression for the GABAA receptor subunit β1 compared with isoflurane-sensitive mice, indicating that the GABAA receptor may be required for its anesthetic effect. In mice, isoflurane (1.5% for 4 hours) impairs spatial recognition memory in the spontaneous alternation test and Y-maze and increases levels of phosphorylated Jnk1/2 for at least 24 hours.{37283} Formulations containing isoflurane have been used as anesthetics.
Brand:CaymanSKU:23989 - 5 gAvailable on backorder
Isoforskolin is a naturally occurring diterpene originally isolated from the Indian coleus plant C. forskohlii.{41420} It demonstrates positive inotropic effects ex vivo in guinea pig atria (EC50 = 1.09 μM).{41421} In vivo, isoforskolin is antihypertensive, decreasing systolic blood pressure by 28 mmHg in spontaneously hypertensive rats when administered at 25 mg/kg per day, p.o. for 5 days. Pretreatment of rats with isoforskolin (10 mg/kg, i.p.) decreases LPS-induced lung injury by decreasing karyocyte, neutrophil count, and protein content in bronchoalveolar lavage fluid, and ameliorating LPS-induced lung morphological changes.{41423} Isoforskolin (1 mg/kg, i.p.) decreases mean arthritis index in a mouse model of Lyme arthritis induced by injection of B. burgdorferi basic membrane protein A (BmpA) into the tibiotarsal joint cavity.{41424} Isoforskolin also activates membranous mammalian adenylyl cyclase (AC) expressed in insect cells (EC50s = 0.8, 13.3, and 7.4 μM for AC1, AC2, and AC5, respectively).{41422}
Brand:CaymanSKU:11716 - 1 mgAvailable on backorder
Isogarcinol is a natural polyisoprenylated benzophenone first isolated from plant species in the genus Garcinia. It has immunosuppressant actions, inhibiting the protein phosphatase calcineurin (IC50 = 36 µM) and suppressing the proliferation of T cells.{33025} Oral administration of isogarcinol in mice decreases delayed type hypersensitivity, prolongs graft survival in allogeneic skin transplants, suppresses inflammation in collagen-induced arthritis, and reduces clinical symptoms in experimental autoimmune encephalomyelitis.{33025,33026,33028} Isogarcinol inhibits the proliferation of HL-60 and PC-3 cancer cells (IC50s = 4 and 8 µg/ml, respectively) through cell cycle arrest and apoptosis.{33027}
Brand:CaymanSKU:21164 -Out of stock
Isogarcinol is a natural polyisoprenylated benzophenone first isolated from plant species in the genus Garcinia. It has immunosuppressant actions, inhibiting the protein phosphatase calcineurin (IC50 = 36 µM) and suppressing the proliferation of T cells.{33025} Oral administration of isogarcinol in mice decreases delayed type hypersensitivity, prolongs graft survival in allogeneic skin transplants, suppresses inflammation in collagen-induced arthritis, and reduces clinical symptoms in experimental autoimmune encephalomyelitis.{33025,33026,33028} Isogarcinol inhibits the proliferation of HL-60 and PC-3 cancer cells (IC50s = 4 and 8 µg/ml, respectively) through cell cycle arrest and apoptosis.{33027}
Brand:CaymanSKU:21164 -Out of stock
Isogarcinol is a natural polyisoprenylated benzophenone first isolated from plant species in the genus Garcinia. It has immunosuppressant actions, inhibiting the protein phosphatase calcineurin (IC50 = 36 µM) and suppressing the proliferation of T cells.{33025} Oral administration of isogarcinol in mice decreases delayed type hypersensitivity, prolongs graft survival in allogeneic skin transplants, suppresses inflammation in collagen-induced arthritis, and reduces clinical symptoms in experimental autoimmune encephalomyelitis.{33025,33026,33028} Isogarcinol inhibits the proliferation of HL-60 and PC-3 cancer cells (IC50s = 4 and 8 µg/ml, respectively) through cell cycle arrest and apoptosis.{33027}
Brand:CaymanSKU:21164 -Out of stock
Isogarcinol is a natural polyisoprenylated benzophenone first isolated from plant species in the genus Garcinia. It has immunosuppressant actions, inhibiting the protein phosphatase calcineurin (IC50 = 36 µM) and suppressing the proliferation of T cells.{33025} Oral administration of isogarcinol in mice decreases delayed type hypersensitivity, prolongs graft survival in allogeneic skin transplants, suppresses inflammation in collagen-induced arthritis, and reduces clinical symptoms in experimental autoimmune encephalomyelitis.{33025,33026,33028} Isogarcinol inhibits the proliferation of HL-60 and PC-3 cancer cells (IC50s = 4 and 8 µg/ml, respectively) through cell cycle arrest and apoptosis.{33027}
Brand:CaymanSKU:21164 -Out of stock
Isoginkgetin is a biflavonoid that has been found in G. biloba and is an inhibitor of pre-mRNA splicing.{37675} Isoginkgetin (33 μM) reduces the activity of an mRNA-dependent luciferase reporter by 5-fold, shifts the composition of total RNA extract from predominantly mRNA to pre-mRNA, and arrests cell growth in HEK293 cells. Isoginkgetin (10 μM) suppresses mouse lymphocyte proliferation induced by concanavalin A (Con A; Item No. 14951) and LPS by approximately 87 and 90%, respectively.{37676} It also suppresses arachidonic acid release induced by phorbol 12-myristate 13-acetate (PMA; Item No. 10008014) and the calcium ionophore A23187 (Item No. 11016) by 32.5 and 48.4%, respectively, in rat peritoneal macrophages when used at a concentration of 10 μM.{37677} Isoginkgetin (5-20 μM) reduces matrix metalloproteinase-9 (MMP-9) activity, expression, and mRNA levels in and decreases cell invasion by HT1080 fibrosarcoma cells in a concentration-dependent manner.{37678}
Brand:CaymanSKU:25104 - 1 mgAvailable on backorder
Isoginkgetin is a biflavonoid that has been found in G. biloba and is an inhibitor of pre-mRNA splicing.{37675} Isoginkgetin (33 μM) reduces the activity of an mRNA-dependent luciferase reporter by 5-fold, shifts the composition of total RNA extract from predominantly mRNA to pre-mRNA, and arrests cell growth in HEK293 cells. Isoginkgetin (10 μM) suppresses mouse lymphocyte proliferation induced by concanavalin A (Con A; Item No. 14951) and LPS by approximately 87 and 90%, respectively.{37676} It also suppresses arachidonic acid release induced by phorbol 12-myristate 13-acetate (PMA; Item No. 10008014) and the calcium ionophore A23187 (Item No. 11016) by 32.5 and 48.4%, respectively, in rat peritoneal macrophages when used at a concentration of 10 μM.{37677} Isoginkgetin (5-20 μM) reduces matrix metalloproteinase-9 (MMP-9) activity, expression, and mRNA levels in and decreases cell invasion by HT1080 fibrosarcoma cells in a concentration-dependent manner.{37678}
Brand:CaymanSKU:25104 - 10 mgAvailable on backorder
Isoginkgetin is a biflavonoid that has been found in G. biloba and is an inhibitor of pre-mRNA splicing.{37675} Isoginkgetin (33 μM) reduces the activity of an mRNA-dependent luciferase reporter by 5-fold, shifts the composition of total RNA extract from predominantly mRNA to pre-mRNA, and arrests cell growth in HEK293 cells. Isoginkgetin (10 μM) suppresses mouse lymphocyte proliferation induced by concanavalin A (Con A; Item No. 14951) and LPS by approximately 87 and 90%, respectively.{37676} It also suppresses arachidonic acid release induced by phorbol 12-myristate 13-acetate (PMA; Item No. 10008014) and the calcium ionophore A23187 (Item No. 11016) by 32.5 and 48.4%, respectively, in rat peritoneal macrophages when used at a concentration of 10 μM.{37677} Isoginkgetin (5-20 μM) reduces matrix metalloproteinase-9 (MMP-9) activity, expression, and mRNA levels in and decreases cell invasion by HT1080 fibrosarcoma cells in a concentration-dependent manner.{37678}
Brand:CaymanSKU:25104 - 25 mgAvailable on backorder
Isoginkgetin is a biflavonoid that has been found in G. biloba and is an inhibitor of pre-mRNA splicing.{37675} Isoginkgetin (33 μM) reduces the activity of an mRNA-dependent luciferase reporter by 5-fold, shifts the composition of total RNA extract from predominantly mRNA to pre-mRNA, and arrests cell growth in HEK293 cells. Isoginkgetin (10 μM) suppresses mouse lymphocyte proliferation induced by concanavalin A (Con A; Item No. 14951) and LPS by approximately 87 and 90%, respectively.{37676} It also suppresses arachidonic acid release induced by phorbol 12-myristate 13-acetate (PMA; Item No. 10008014) and the calcium ionophore A23187 (Item No. 11016) by 32.5 and 48.4%, respectively, in rat peritoneal macrophages when used at a concentration of 10 μM.{37677} Isoginkgetin (5-20 μM) reduces matrix metalloproteinase-9 (MMP-9) activity, expression, and mRNA levels in and decreases cell invasion by HT1080 fibrosarcoma cells in a concentration-dependent manner.{37678}
Brand:CaymanSKU:25104 - 5 mgAvailable on backorder
Isoguanine is a natural isomer of guanine originally isolated from Croton seed but is also a product of oxidative damage to the adenine base in DNA.{38758,38759} It can be formed through oxidative damage to deoxyadenosine and deoxyadenosine-ATP (d-ATP) as well as single- and double-stranded DNA and induces a parallel-stranded DNA structure when incorporated into DNA.{38759,38760} It is mutagenic to S. tymphimurium in the Ames test and induces sister chromatid exchange, a measure of mutagenicity, in isolated human peripheral blood lymphocytes.{38761}
Brand:CaymanSKU:21703 -Out of stock
Isoguanine is a natural isomer of guanine originally isolated from Croton seed but is also a product of oxidative damage to the adenine base in DNA.{38758,38759} It can be formed through oxidative damage to deoxyadenosine and deoxyadenosine-ATP (d-ATP) as well as single- and double-stranded DNA and induces a parallel-stranded DNA structure when incorporated into DNA.{38759,38760} It is mutagenic to S. tymphimurium in the Ames test and induces sister chromatid exchange, a measure of mutagenicity, in isolated human peripheral blood lymphocytes.{38761}
Brand:CaymanSKU:21703 -Out of stock
Isoguanine is a natural isomer of guanine originally isolated from Croton seed but is also a product of oxidative damage to the adenine base in DNA.{38758,38759} It can be formed through oxidative damage to deoxyadenosine and deoxyadenosine-ATP (d-ATP) as well as single- and double-stranded DNA and induces a parallel-stranded DNA structure when incorporated into DNA.{38759,38760} It is mutagenic to S. tymphimurium in the Ames test and induces sister chromatid exchange, a measure of mutagenicity, in isolated human peripheral blood lymphocytes.{38761}
Brand:CaymanSKU:21703 -Out of stock
Isoguanine is a natural isomer of guanine originally isolated from Croton seed but is also a product of oxidative damage to the adenine base in DNA.{38758,38759} It can be formed through oxidative damage to deoxyadenosine and deoxyadenosine-ATP (d-ATP) as well as single- and double-stranded DNA and induces a parallel-stranded DNA structure when incorporated into DNA.{38759,38760} It is mutagenic to S. tymphimurium in the Ames test and induces sister chromatid exchange, a measure of mutagenicity, in isolated human peripheral blood lymphocytes.{38761}
Brand:CaymanSKU:21703 -Out of stock
Isoimperatorin is a natural furanocoumarin that can be isolated from a variety of plant parts. It inhibits cytochrome P450 (CYP) isoform 1A activity, in particular blocking hepatic ethoxyresorufin O-dealkylase activity.{32150,32151} Through its effects on CYP1A, isoimperatorin reduces the metabolism of polycyclic aromatic hydrocarbons and aflatoxin B1 (Item No. 11293) to reactive metabolites.{32151,32152} Isoimperatorin also induces the expression of glutathione S-transferase α by activating Nrf2.{32152}
Brand:CaymanSKU:19851 -Available on backorder
Isoimperatorin is a natural furanocoumarin that can be isolated from a variety of plant parts. It inhibits cytochrome P450 (CYP) isoform 1A activity, in particular blocking hepatic ethoxyresorufin O-dealkylase activity.{32150,32151} Through its effects on CYP1A, isoimperatorin reduces the metabolism of polycyclic aromatic hydrocarbons and aflatoxin B1 (Item No. 11293) to reactive metabolites.{32151,32152} Isoimperatorin also induces the expression of glutathione S-transferase α by activating Nrf2.{32152}
Brand:CaymanSKU:19851 -Available on backorder
Isoimperatorin is a natural furanocoumarin that can be isolated from a variety of plant parts. It inhibits cytochrome P450 (CYP) isoform 1A activity, in particular blocking hepatic ethoxyresorufin O-dealkylase activity.{32150,32151} Through its effects on CYP1A, isoimperatorin reduces the metabolism of polycyclic aromatic hydrocarbons and aflatoxin B1 (Item No. 11293) to reactive metabolites.{32151,32152} Isoimperatorin also induces the expression of glutathione S-transferase α by activating Nrf2.{32152}
Brand:CaymanSKU:19851 -Available on backorder
Isoimperatorin is a natural furanocoumarin that can be isolated from a variety of plant parts. It inhibits cytochrome P450 (CYP) isoform 1A activity, in particular blocking hepatic ethoxyresorufin O-dealkylase activity.{32150,32151} Through its effects on CYP1A, isoimperatorin reduces the metabolism of polycyclic aromatic hydrocarbons and aflatoxin B1 (Item No. 11293) to reactive metabolites.{32151,32152} Isoimperatorin also induces the expression of glutathione S-transferase α by activating Nrf2.{32152}
Brand:CaymanSKU:19851 -Available on backorder
Isokotanin B is a bicoumarin fungal metabolite originally isolated from A. alliaceus.{36675} Dietary administration of isokotanin B (100 ppm) reduces C. hemipterus larvae feeding by 21%.
Brand:CaymanSKU:25082 - 2.5 mgAvailable on backorder
Isokotanin B is a bicoumarin fungal metabolite originally isolated from A. alliaceus.{36675} Dietary administration of isokotanin B (100 ppm) reduces C. hemipterus larvae feeding by 21%.
Brand:CaymanSKU:25082 - 500 µgAvailable on backorder
Isoliquiritigenin is a flavonoid that is found in Glycyrrhizae species and has diverse biological activities including anticancer, anti-steatotic, antioxidant, anti-inflammatory, gastroprotective, and estrogenic properties.{43332,43333,19281,19284,29598} It reduces tumor growth in an NCI-H1975 non-small cell lung cancer (NSCLC) mouse xenograft model when administered at doses of 1 and 5 mg/kg.{43332} Isoliquiritigenin (10 mg/kg per day) inhibits hepatic steatosis, as indicated by reduced hepatic fat and triglyceride accumulation, and increases in hepatic thiobarbituric acid-reactive substances (TBARS), inducible nitric oxide synthase (iNOS), and COX-2 levels in mice fed a high-fat diet.{19284} It also inhibits LPS-induced increases in IL-1β and IL-6 levels in J774A.1 murine macrophages (IC50s = 7.2 and 7.16 μM, respectively).{43333} Isoliquiritigenin (5 and 10 mg/kg) reduces gastric acid secretion and gastric ulcer formation in pylorus-ligated rats.{19281} It is an estrogen receptor α (ERα) and ERβ agonist (IC50s = 16 and 7.8 μM, respectively) and induces estrogen-responsive alkaline phosphatase activity in Ishikawa endometrial cancer cells (EC50 = 2.7 μM).{29598} Isoliquiritigenin is also a histamine H2 receptor and liver X receptor α (LXRα) antagonist.{19281,19284}
Brand:CaymanSKU:10739 - 1 mgAvailable on backorder
Isoliquiritigenin is a flavonoid that is found in Glycyrrhizae species and has diverse biological activities including anticancer, anti-steatotic, antioxidant, anti-inflammatory, gastroprotective, and estrogenic properties.{43332,43333,19281,19284,29598} It reduces tumor growth in an NCI-H1975 non-small cell lung cancer (NSCLC) mouse xenograft model when administered at doses of 1 and 5 mg/kg.{43332} Isoliquiritigenin (10 mg/kg per day) inhibits hepatic steatosis, as indicated by reduced hepatic fat and triglyceride accumulation, and increases in hepatic thiobarbituric acid-reactive substances (TBARS), inducible nitric oxide synthase (iNOS), and COX-2 levels in mice fed a high-fat diet.{19284} It also inhibits LPS-induced increases in IL-1β and IL-6 levels in J774A.1 murine macrophages (IC50s = 7.2 and 7.16 μM, respectively).{43333} Isoliquiritigenin (5 and 10 mg/kg) reduces gastric acid secretion and gastric ulcer formation in pylorus-ligated rats.{19281} It is an estrogen receptor α (ERα) and ERβ agonist (IC50s = 16 and 7.8 μM, respectively) and induces estrogen-responsive alkaline phosphatase activity in Ishikawa endometrial cancer cells (EC50 = 2.7 μM).{29598} Isoliquiritigenin is also a histamine H2 receptor and liver X receptor α (LXRα) antagonist.{19281,19284}
Brand:CaymanSKU:10739 - 10 mgAvailable on backorder
Isoliquiritigenin is a flavonoid that is found in Glycyrrhizae species and has diverse biological activities including anticancer, anti-steatotic, antioxidant, anti-inflammatory, gastroprotective, and estrogenic properties.{43332,43333,19281,19284,29598} It reduces tumor growth in an NCI-H1975 non-small cell lung cancer (NSCLC) mouse xenograft model when administered at doses of 1 and 5 mg/kg.{43332} Isoliquiritigenin (10 mg/kg per day) inhibits hepatic steatosis, as indicated by reduced hepatic fat and triglyceride accumulation, and increases in hepatic thiobarbituric acid-reactive substances (TBARS), inducible nitric oxide synthase (iNOS), and COX-2 levels in mice fed a high-fat diet.{19284} It also inhibits LPS-induced increases in IL-1β and IL-6 levels in J774A.1 murine macrophages (IC50s = 7.2 and 7.16 μM, respectively).{43333} Isoliquiritigenin (5 and 10 mg/kg) reduces gastric acid secretion and gastric ulcer formation in pylorus-ligated rats.{19281} It is an estrogen receptor α (ERα) and ERβ agonist (IC50s = 16 and 7.8 μM, respectively) and induces estrogen-responsive alkaline phosphatase activity in Ishikawa endometrial cancer cells (EC50 = 2.7 μM).{29598} Isoliquiritigenin is also a histamine H2 receptor and liver X receptor α (LXRα) antagonist.{19281,19284}
Brand:CaymanSKU:10739 - 25 mgAvailable on backorder
Isoliquiritigenin is a flavonoid that is found in Glycyrrhizae species and has diverse biological activities including anticancer, anti-steatotic, antioxidant, anti-inflammatory, gastroprotective, and estrogenic properties.{43332,43333,19281,19284,29598} It reduces tumor growth in an NCI-H1975 non-small cell lung cancer (NSCLC) mouse xenograft model when administered at doses of 1 and 5 mg/kg.{43332} Isoliquiritigenin (10 mg/kg per day) inhibits hepatic steatosis, as indicated by reduced hepatic fat and triglyceride accumulation, and increases in hepatic thiobarbituric acid-reactive substances (TBARS), inducible nitric oxide synthase (iNOS), and COX-2 levels in mice fed a high-fat diet.{19284} It also inhibits LPS-induced increases in IL-1β and IL-6 levels in J774A.1 murine macrophages (IC50s = 7.2 and 7.16 μM, respectively).{43333} Isoliquiritigenin (5 and 10 mg/kg) reduces gastric acid secretion and gastric ulcer formation in pylorus-ligated rats.{19281} It is an estrogen receptor α (ERα) and ERβ agonist (IC50s = 16 and 7.8 μM, respectively) and induces estrogen-responsive alkaline phosphatase activity in Ishikawa endometrial cancer cells (EC50 = 2.7 μM).{29598} Isoliquiritigenin is also a histamine H2 receptor and liver X receptor α (LXRα) antagonist.{19281,19284}
Brand:CaymanSKU:10739 - 5 mgAvailable on backorder
Isoliquiritin is a flavonoid that has been found in G. uralensis roots and has diverse biological activities.{54056,54057,54058} It inhibits LPS-induced nitrite and prostaglandin E2 (PGE2; Item No. 14010) production in RAW 264.7 cells when used at a concentration of 1.6 µM.{54056} Isoliquiritin (5-500 µg/ml) inhibits tube formation by isolated rat aortic endothelial cells.{54057} In vivo, isoliquiritin reduces carmine content, a marker of blood vessel formation, and pouch fluid weight in a mouse model of adjuvant-induced pouch granuloma formation (ED50s = 1.46 and 0.771 mg/kg, respectively). It increases cortical, hippocampal, and hypothalamic serotonin (5-HT) and norepinephrine levels and decreases immobility time in the forced swim and tail suspension tests in mice when administered at doses ranging from 10 to 40 mg/kg.{54058}
Brand:CaymanSKU:30270 - 10 mgAvailable on backorder
Isoliquiritin is a flavonoid that has been found in G. uralensis roots and has diverse biological activities.{54056,54057,54058} It inhibits LPS-induced nitrite and prostaglandin E2 (PGE2; Item No. 14010) production in RAW 264.7 cells when used at a concentration of 1.6 µM.{54056} Isoliquiritin (5-500 µg/ml) inhibits tube formation by isolated rat aortic endothelial cells.{54057} In vivo, isoliquiritin reduces carmine content, a marker of blood vessel formation, and pouch fluid weight in a mouse model of adjuvant-induced pouch granuloma formation (ED50s = 1.46 and 0.771 mg/kg, respectively). It increases cortical, hippocampal, and hypothalamic serotonin (5-HT) and norepinephrine levels and decreases immobility time in the forced swim and tail suspension tests in mice when administered at doses ranging from 10 to 40 mg/kg.{54058}
Brand:CaymanSKU:30270 - 25 mgAvailable on backorder
Isoliquiritin is a flavonoid that has been found in G. uralensis roots and has diverse biological activities.{54056,54057,54058} It inhibits LPS-induced nitrite and prostaglandin E2 (PGE2; Item No. 14010) production in RAW 264.7 cells when used at a concentration of 1.6 µM.{54056} Isoliquiritin (5-500 µg/ml) inhibits tube formation by isolated rat aortic endothelial cells.{54057} In vivo, isoliquiritin reduces carmine content, a marker of blood vessel formation, and pouch fluid weight in a mouse model of adjuvant-induced pouch granuloma formation (ED50s = 1.46 and 0.771 mg/kg, respectively). It increases cortical, hippocampal, and hypothalamic serotonin (5-HT) and norepinephrine levels and decreases immobility time in the forced swim and tail suspension tests in mice when administered at doses ranging from 10 to 40 mg/kg.{54058}
Brand:CaymanSKU:30270 - 5 mgAvailable on backorder
Isoliquiritin is a flavonoid that has been found in G. uralensis roots and has diverse biological activities.{54056,54057,54058} It inhibits LPS-induced nitrite and prostaglandin E2 (PGE2; Item No. 14010) production in RAW 264.7 cells when used at a concentration of 1.6 µM.{54056} Isoliquiritin (5-500 µg/ml) inhibits tube formation by isolated rat aortic endothelial cells.{54057} In vivo, isoliquiritin reduces carmine content, a marker of blood vessel formation, and pouch fluid weight in a mouse model of adjuvant-induced pouch granuloma formation (ED50s = 1.46 and 0.771 mg/kg, respectively). It increases cortical, hippocampal, and hypothalamic serotonin (5-HT) and norepinephrine levels and decreases immobility time in the forced swim and tail suspension tests in mice when administered at doses ranging from 10 to 40 mg/kg.{54058}
Brand:CaymanSKU:30270 - 50 mgAvailable on backorder
Isolithocholic acid is a bile acid that is formed via microbial metabolism of lithocholic acid (LCA; Item No. 20253) or lithocholic acid 3α-sulfate (Item No. 20676).{54013,43814} Isolithocholic acid (0.01%) inhibits spore germination induced by taurocholic acid (TCA; Item No. 16215) in the C. difficile strains CD196, M68, BI9, and 630, as well as inhibits growth and decreases the cytotoxicity of C. difficile culture supernatants to Vero cells when used at a concentration of 0.0003%.{54006} Fecal levels of isolithocholic acid are decreased in a rat model of high-fat diet-induced obesity compared with rats fed a normal diet.{54007}
Brand:CaymanSKU:29545 - 10 mgAvailable on backorder
Isolithocholic acid is a bile acid that is formed via microbial metabolism of lithocholic acid (LCA; Item No. 20253) or lithocholic acid 3α-sulfate (Item No. 20676).{54013,43814} Isolithocholic acid (0.01%) inhibits spore germination induced by taurocholic acid (TCA; Item No. 16215) in the C. difficile strains CD196, M68, BI9, and 630, as well as inhibits growth and decreases the cytotoxicity of C. difficile culture supernatants to Vero cells when used at a concentration of 0.0003%.{54006} Fecal levels of isolithocholic acid are decreased in a rat model of high-fat diet-induced obesity compared with rats fed a normal diet.{54007}
Brand:CaymanSKU:29545 - 25 mgAvailable on backorder
Isolithocholic acid is a bile acid that is formed via microbial metabolism of lithocholic acid (LCA; Item No. 20253) or lithocholic acid 3α-sulfate (Item No. 20676).{54013,43814} Isolithocholic acid (0.01%) inhibits spore germination induced by taurocholic acid (TCA; Item No. 16215) in the C. difficile strains CD196, M68, BI9, and 630, as well as inhibits growth and decreases the cytotoxicity of C. difficile culture supernatants to Vero cells when used at a concentration of 0.0003%.{54006} Fecal levels of isolithocholic acid are decreased in a rat model of high-fat diet-induced obesity compared with rats fed a normal diet.{54007}
Brand:CaymanSKU:29545 - 5 mgAvailable on backorder
Isomaltose is a glucose disaccharide with an α-(1→6) linkage, as opposed to the α-(1→4) linkage found in maltose. It can be liberated from dextran by dextranase and is hydrolyzed to D-glucose by isomaltase through an α-D-glucosidase-type action. Congenital sucrase-isomaltase deficiency is a rare autosomal intestinal disorder resulting from mutations affecting the gene encoding the proprotein from which sucrase and isomaltase are produced.{33572}
Brand:CaymanSKU:20797 -Available on backorder
Isomaltose is a glucose disaccharide with an α-(1→6) linkage, as opposed to the α-(1→4) linkage found in maltose. It can be liberated from dextran by dextranase and is hydrolyzed to D-glucose by isomaltase through an α-D-glucosidase-type action. Congenital sucrase-isomaltase deficiency is a rare autosomal intestinal disorder resulting from mutations affecting the gene encoding the proprotein from which sucrase and isomaltase are produced.{33572}
Brand:CaymanSKU:20797 -Available on backorder
Isomaltose is a glucose disaccharide with an α-(1→6) linkage, as opposed to the α-(1→4) linkage found in maltose. It can be liberated from dextran by dextranase and is hydrolyzed to D-glucose by isomaltase through an α-D-glucosidase-type action. Congenital sucrase-isomaltase deficiency is a rare autosomal intestinal disorder resulting from mutations affecting the gene encoding the proprotein from which sucrase and isomaltase are produced.{33572}
Brand:CaymanSKU:20797 -Available on backorder
Isomaltose is a glucose disaccharide with an α-(1→6) linkage, as opposed to the α-(1→4) linkage found in maltose. It can be liberated from dextran by dextranase and is hydrolyzed to D-glucose by isomaltase through an α-D-glucosidase-type action. Congenital sucrase-isomaltase deficiency is a rare autosomal intestinal disorder resulting from mutations affecting the gene encoding the proprotein from which sucrase and isomaltase are produced.{33572}
Brand:CaymanSKU:20797 -Available on backorder
Isoniazid is an antibiotic that acts as a prodrug, being converted by bacterial catalase-peroxidases to form isonicotinic acyl-NADH complex, which inhibits mycolic acid biosynthesis.{26434} It is effective against several species of Mycobacterium, including M. tuberculosis.{13371,27318}
Brand:CaymanSKU:20378 -Available on backorder
Isoniazid is an antibiotic that acts as a prodrug, being converted by bacterial catalase-peroxidases to form isonicotinic acyl-NADH complex, which inhibits mycolic acid biosynthesis.{26434} It is effective against several species of Mycobacterium, including M. tuberculosis.{13371,27318}
Brand:CaymanSKU:20378 -Available on backorder
Isoorientin is a flavonoid that has been found in G. olivieri and has diverse biological activities.{47348,47349,47350} It induces apoptosis in and reduces cell viability of PATU-8988 and PANC-1 pancreatic cancer cells in a concentration-dependent manner.{47348} Isoorientin reduces expression of COX-2, IL-6, 5-lipoxygenase (5-LO), and TNF-α in RAW 264.7 cells.{47349} In vivo, isoorientin (20 mg/kg) reduces carrageenan-induced paw edema and air pouch blood vessel swelling in mice. It increases stomach levels of superoxide dismutase (SOD) and glutathione (GSH) and reduces ulcer area in a rat model of gastric ulcers induced by indomethacin (Item No. 70270).{47350}
Brand:CaymanSKU:26862 - 10 mgAvailable on backorder
Isoorientin is a flavonoid that has been found in G. olivieri and has diverse biological activities.{47348,47349,47350} It induces apoptosis in and reduces cell viability of PATU-8988 and PANC-1 pancreatic cancer cells in a concentration-dependent manner.{47348} Isoorientin reduces expression of COX-2, IL-6, 5-lipoxygenase (5-LO), and TNF-α in RAW 264.7 cells.{47349} In vivo, isoorientin (20 mg/kg) reduces carrageenan-induced paw edema and air pouch blood vessel swelling in mice. It increases stomach levels of superoxide dismutase (SOD) and glutathione (GSH) and reduces ulcer area in a rat model of gastric ulcers induced by indomethacin (Item No. 70270).{47350}
Brand:CaymanSKU:26862 - 25 mgAvailable on backorder
Isoorientin is a flavonoid that has been found in G. olivieri and has diverse biological activities.{47348,47349,47350} It induces apoptosis in and reduces cell viability of PATU-8988 and PANC-1 pancreatic cancer cells in a concentration-dependent manner.{47348} Isoorientin reduces expression of COX-2, IL-6, 5-lipoxygenase (5-LO), and TNF-α in RAW 264.7 cells.{47349} In vivo, isoorientin (20 mg/kg) reduces carrageenan-induced paw edema and air pouch blood vessel swelling in mice. It increases stomach levels of superoxide dismutase (SOD) and glutathione (GSH) and reduces ulcer area in a rat model of gastric ulcers induced by indomethacin (Item No. 70270).{47350}
Brand:CaymanSKU:26862 - 5 mgAvailable on backorder
Isoorientin is a flavonoid that has been found in G. olivieri and has diverse biological activities.{47348,47349,47350} It induces apoptosis in and reduces cell viability of PATU-8988 and PANC-1 pancreatic cancer cells in a concentration-dependent manner.{47348} Isoorientin reduces expression of COX-2, IL-6, 5-lipoxygenase (5-LO), and TNF-α in RAW 264.7 cells.{47349} In vivo, isoorientin (20 mg/kg) reduces carrageenan-induced paw edema and air pouch blood vessel swelling in mice. It increases stomach levels of superoxide dismutase (SOD) and glutathione (GSH) and reduces ulcer area in a rat model of gastric ulcers induced by indomethacin (Item No. 70270).{47350}
Brand:CaymanSKU:26862 - 50 mgAvailable on backorder
Pentedrone (Item No. 11011) is a substituted cathinone and designer drug that is similar to methcathinone, a controlled psychoactive stimulant Isopentedrone is a variant of pentedrone in which the α-propyl and β-keto groups have switched positions. This by-product of the synthesis of pentedrone has been detected in seized designer drug powders.{21245} The physiological and toxicological effects of this compound have not been characterized. This product is intended for forensic and research purposes.
Brand:CaymanSKU:11563 - 1 mgAvailable on backorder
Pentedrone (Item No. 11011) is a substituted cathinone and designer drug that is similar to methcathinone, a controlled psychoactive stimulant Isopentedrone is a variant of pentedrone in which the α-propyl and β-keto groups have switched positions. This by-product of the synthesis of pentedrone has been detected in seized designer drug powders.{21245} The physiological and toxicological effects of this compound have not been characterized. This product is intended for forensic and research purposes.
Brand:CaymanSKU:11563 - 10 mgAvailable on backorder
Pentedrone (Item No. 11011) is a substituted cathinone and designer drug that is similar to methcathinone, a controlled psychoactive stimulant Isopentedrone is a variant of pentedrone in which the α-propyl and β-keto groups have switched positions. This by-product of the synthesis of pentedrone has been detected in seized designer drug powders.{21245} The physiological and toxicological effects of this compound have not been characterized. This product is intended for forensic and research purposes.
Brand:CaymanSKU:11563 - 5 mgAvailable on backorder
Isoprinosine is a complex of acetaminobenzoic acid, dimethylaminoisopropanol, and inosine in a 3:3:1 ratio. It has a number of immunomodulatory effects, including inducing T-lymphocyte differentiation, augmenting macrophage and NK cell functions, and stimulating IL-2 production.{29644,29646,29643} Through these effects and others, isoprinosine shows antiviral activity and has applications against subacute sclerosing panencephalitis.{29643,29645} It also restores depressed immune responses in cancer patients after irradiation and reduces the incidence of infection in leukemia patients undergoing chemotherapy.{29643}
Brand:CaymanSKU:-Out of stock
Isoprinosine is a complex of acetaminobenzoic acid, dimethylaminoisopropanol, and inosine in a 3:3:1 ratio. It has a number of immunomodulatory effects, including inducing T-lymphocyte differentiation, augmenting macrophage and NK cell functions, and stimulating IL-2 production.{29644,29646,29643} Through these effects and others, isoprinosine shows antiviral activity and has applications against subacute sclerosing panencephalitis.{29643,29645} It also restores depressed immune responses in cancer patients after irradiation and reduces the incidence of infection in leukemia patients undergoing chemotherapy.{29643}
Brand:CaymanSKU:-Out of stock
Isoprinosine is a complex of acetaminobenzoic acid, dimethylaminoisopropanol, and inosine in a 3:3:1 ratio. It has a number of immunomodulatory effects, including inducing T-lymphocyte differentiation, augmenting macrophage and NK cell functions, and stimulating IL-2 production.{29644,29646,29643} Through these effects and others, isoprinosine shows antiviral activity and has applications against subacute sclerosing panencephalitis.{29643,29645} It also restores depressed immune responses in cancer patients after irradiation and reduces the incidence of infection in leukemia patients undergoing chemotherapy.{29643}
Brand:CaymanSKU:-Out of stock
Isoprinosine is a complex of acetaminobenzoic acid, dimethylaminoisopropanol, and inosine in a 3:3:1 ratio. It has a number of immunomodulatory effects, including inducing T-lymphocyte differentiation, augmenting macrophage and NK cell functions, and stimulating IL-2 production.{29644,29646,29643} Through these effects and others, isoprinosine shows antiviral activity and has applications against subacute sclerosing panencephalitis.{29643,29645} It also restores depressed immune responses in cancer patients after irradiation and reduces the incidence of infection in leukemia patients undergoing chemotherapy.{29643}
Brand:CaymanSKU:-Out of stock
Isopropyl benzenesulfonate is a sulfonate ester genotoxic impurity found in active pharmaceutical ingredients.{28984} It has potential to exert toxic effects in bacterial and mammalian cells.
Brand:CaymanSKU:-Available on backorder
Isopropyl benzenesulfonate is a sulfonate ester genotoxic impurity found in active pharmaceutical ingredients.{28984} It has potential to exert toxic effects in bacterial and mammalian cells.
Brand:CaymanSKU:-Available on backorder
Isopropyl dodec-11-enylfluorophosphonate is an organophosphorus ester that antagonizes the central cannabinoid (CB1) receptor and inhibits FAAH with similar potencies (IC50s = 2 nM).{22660,20684} At 30 mg/kg, this compound inhibits 99% of the brain neuropathy target esterase-lysophospholipase, which is attributed to causing delayed toxicity in mice.{22660}
Brand:CaymanSKU:11613 - 1 mgAvailable on backorder
Isopropyl dodec-11-enylfluorophosphonate is an organophosphorus ester that antagonizes the central cannabinoid (CB1) receptor and inhibits FAAH with similar potencies (IC50s = 2 nM).{22660,20684} At 30 mg/kg, this compound inhibits 99% of the brain neuropathy target esterase-lysophospholipase, which is attributed to causing delayed toxicity in mice.{22660}
Brand:CaymanSKU:11613 - 10 mgAvailable on backorder
Isopropyl dodec-11-enylfluorophosphonate is an organophosphorus ester that antagonizes the central cannabinoid (CB1) receptor and inhibits FAAH with similar potencies (IC50s = 2 nM).{22660,20684} At 30 mg/kg, this compound inhibits 99% of the brain neuropathy target esterase-lysophospholipase, which is attributed to causing delayed toxicity in mice.{22660}
Brand:CaymanSKU:11613 - 5 mgAvailable on backorder
Isopropyl dodec-11-enylfluorophosphonate is an organophosphorus ester that antagonizes the central cannabinoid (CB1) receptor and inhibits FAAH with similar potencies (IC50s = 2 nM).{22660,20684} At 30 mg/kg, this compound inhibits 99% of the brain neuropathy target esterase-lysophospholipase, which is attributed to causing delayed toxicity in mice.{22660}
Brand:CaymanSKU:11613 - 500 µgAvailable on backorder
Isoproterenol is a selective β-adrenoceptor agonist that shows high affinity for β1, β2, and β3 (Ki = 224, 458, and 1,570 nM, respectively).{25395,25569} Low concentrations of isoproterenol are sufficient to inhibit contractions in isolated field stimulated rat vas deferens (EC50 = 45.6 nM).{25571} Through its effects on β-adrenoceptor, isoproterenol increases cAMP levels and can activate protein kinase A and ERK1/2.{20876,20862,25568,25569}
Brand:CaymanSKU:- Isoproterenol is a selective β-adrenoceptor agonist that shows high affinity for β1, β2, and β3 (Ki = 224, 458, and 1,570 nM, respectively).{25395,25569} Low concentrations of isoproterenol are sufficient to inhibit contractions in isolated field stimulated rat vas deferens (EC50 = 45.6 nM).{25571} Through its effects on β-adrenoceptor, isoproterenol increases cAMP levels and can activate protein kinase A and ERK1/2.{20876,20862,25568,25569}
Brand:CaymanSKU:- Isoproterenol is a selective β-adrenoceptor agonist that shows high affinity for β1, β2, and β3 (Ki = 224, 458, and 1,570 nM, respectively).{25395,25569} Low concentrations of isoproterenol are sufficient to inhibit contractions in isolated field stimulated rat vas deferens (EC50 = 45.6 nM).{25571} Through its effects on β-adrenoceptor, isoproterenol increases cAMP levels and can activate protein kinase A and ERK1/2.{20876,20862,25568,25569}
Brand:CaymanSKU:-
Isoquercetin is a flavonoid that has been isolated from A. venetum and has diverse biological activities, including antiviral, anti-apoptotic, and neuroprotective properties.{37646,37647,37648} It reduces viral titers of H5N1 influenza isolates by 79.66% in a plaque assay when used at a concentration of 1 ng/ml.{37646} It inhibits apoptosis, increases cell viability, and decreases the level of reactive oxygen species (ROS) in an oxygen-glucose deprivation/reoxygenation assay when used at concentrations of 25, 50, and 100 µg/ml in primary rat hippocampal neurons and decreases TNF-α-induced cell death in primary mouse hepatocytes (IC50 = 37.5 µM).{37647,37648} Isoquercetin (50 mg/kg) is neuroprotective in a rat model of middle cerebral artery occlusion (MCAO), reducing infarct volume and neurological symptoms, as well as increasing hippocampal expression of Nrf2 and phosphorylation of ERK1/2.{37647}
Brand:CaymanSKU:24926 - 10 mgAvailable on backorder
Isoquercetin is a flavonoid that has been isolated from A. venetum and has diverse biological activities, including antiviral, anti-apoptotic, and neuroprotective properties.{37646,37647,37648} It reduces viral titers of H5N1 influenza isolates by 79.66% in a plaque assay when used at a concentration of 1 ng/ml.{37646} It inhibits apoptosis, increases cell viability, and decreases the level of reactive oxygen species (ROS) in an oxygen-glucose deprivation/reoxygenation assay when used at concentrations of 25, 50, and 100 µg/ml in primary rat hippocampal neurons and decreases TNF-α-induced cell death in primary mouse hepatocytes (IC50 = 37.5 µM).{37647,37648} Isoquercetin (50 mg/kg) is neuroprotective in a rat model of middle cerebral artery occlusion (MCAO), reducing infarct volume and neurological symptoms, as well as increasing hippocampal expression of Nrf2 and phosphorylation of ERK1/2.{37647}
Brand:CaymanSKU:24926 - 100 mgAvailable on backorder
Isoquercetin is a flavonoid that has been isolated from A. venetum and has diverse biological activities, including antiviral, anti-apoptotic, and neuroprotective properties.{37646,37647,37648} It reduces viral titers of H5N1 influenza isolates by 79.66% in a plaque assay when used at a concentration of 1 ng/ml.{37646} It inhibits apoptosis, increases cell viability, and decreases the level of reactive oxygen species (ROS) in an oxygen-glucose deprivation/reoxygenation assay when used at concentrations of 25, 50, and 100 µg/ml in primary rat hippocampal neurons and decreases TNF-α-induced cell death in primary mouse hepatocytes (IC50 = 37.5 µM).{37647,37648} Isoquercetin (50 mg/kg) is neuroprotective in a rat model of middle cerebral artery occlusion (MCAO), reducing infarct volume and neurological symptoms, as well as increasing hippocampal expression of Nrf2 and phosphorylation of ERK1/2.{37647}
Brand:CaymanSKU:24926 - 50 mgAvailable on backorder
Isoquercetin is a flavonoid that has been isolated from A. venetum and has diverse biological activities, including antiviral, anti-apoptotic, and neuroprotective properties.{37646,37647,37648} It reduces viral titers of H5N1 influenza isolates by 79.66% in a plaque assay when used at a concentration of 1 ng/ml.{37646} It inhibits apoptosis, increases cell viability, and decreases the level of reactive oxygen species (ROS) in an oxygen-glucose deprivation/reoxygenation assay when used at concentrations of 25, 50, and 100 µg/ml in primary rat hippocampal neurons and decreases TNF-α-induced cell death in primary mouse hepatocytes (IC50 = 37.5 µM).{37647,37648} Isoquercetin (50 mg/kg) is neuroprotective in a rat model of middle cerebral artery occlusion (MCAO), reducing infarct volume and neurological symptoms, as well as increasing hippocampal expression of Nrf2 and phosphorylation of ERK1/2.{37647}
Brand:CaymanSKU:24926 - 500 mgAvailable on backorder
Isoquercitroside is a 3-O-glucoside of quercetin (Item No. 10005169), that can be found in several plants. Isoquercitroside has higher bioavailability than quercetin and displays antioxidant and chemoprotective effects both in vitro and in vivo.{32682}
Brand:CaymanSKU:20802 -Available on backorder
Isoquercitroside is a 3-O-glucoside of quercetin (Item No. 10005169), that can be found in several plants. Isoquercitroside has higher bioavailability than quercetin and displays antioxidant and chemoprotective effects both in vitro and in vivo.{32682}
Brand:CaymanSKU:20802 -Available on backorder
Isoquercitroside is a 3-O-glucoside of quercetin (Item No. 10005169), that can be found in several plants. Isoquercitroside has higher bioavailability than quercetin and displays antioxidant and chemoprotective effects both in vitro and in vivo.{32682}
Brand:CaymanSKU:20802 -Available on backorder
Isoquercitroside is a 3-O-glucoside of quercetin (Item No. 10005169), that can be found in several plants. Isoquercitroside has higher bioavailability than quercetin and displays antioxidant and chemoprotective effects both in vitro and in vivo.{32682}
Brand:CaymanSKU:20802 -Available on backorder
Isoquinoline-3-carboxylic acid is a synthetic intermediate that has been used to design novel antitumor compounds.{31055}
Brand:CaymanSKU:-Available on backorder