Cayman
Showing 24301–24450 of 45550 results
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Hydroxy bosentan is an active phase I metabolite of bosentan (Item No. 11731) produced by the cytochrome P450 isoforms CYP3A4 and CYP2C9.{39033,39032} Bosentan is an antagonist of the endothelin receptors type A (Ki = 6.5 nM) and type B (Ki = 340 nM).{22374,22376} Up to 20% of the activity of bosentan may be due to the action of hydroxy bosentan because even though it has a lower affinity for endothelin receptors, its concentration is 3-fold higher in plasma.{39034}
Brand:CaymanSKU:22366 -Out of stock
Hydroxy bosentan is an active phase I metabolite of bosentan (Item No. 11731) produced by the cytochrome P450 isoforms CYP3A4 and CYP2C9.{39033,39032} Bosentan is an antagonist of the endothelin receptors type A (Ki = 6.5 nM) and type B (Ki = 340 nM).{22374,22376} Up to 20% of the activity of bosentan may be due to the action of hydroxy bosentan because even though it has a lower affinity for endothelin receptors, its concentration is 3-fold higher in plasma.{39034}
Brand:CaymanSKU:22366 -Out of stock
Buproprion (Item No. 10488) is an inhibitor of the reuptake of dopamine and norepinephrine and is also an antagonist of neuronal acetylcholine nicotinic receptors. Because of its effects on nicotinic receptors, it is used to promote smoking cessation. Hydroxy bupropion is a mixture of enantiomers produced by the metabolism of buproprion by cytochrome P450 2B6.{22910,22909} Compared with buproprion, this racemic mixture produces equal inhibition of norepinephrine reuptake (IC50 = 1.7 µM) and much weaker inhibition of dopamine reuptake (IC50 >10 µM).{22912} Moreover, hydroxyl bupropion isomers are potent antagonists of nicotinic receptors, suggesting that they may substitute for bupropion in smoking cessation.{22912,22911,22909}
Brand:CaymanSKU:9000522 - 1 mgAvailable on backorder
Buproprion (Item No. 10488) is an inhibitor of the reuptake of dopamine and norepinephrine and is also an antagonist of neuronal acetylcholine nicotinic receptors. Because of its effects on nicotinic receptors, it is used to promote smoking cessation. Hydroxy bupropion is a mixture of enantiomers produced by the metabolism of buproprion by cytochrome P450 2B6.{22910,22909} Compared with buproprion, this racemic mixture produces equal inhibition of norepinephrine reuptake (IC50 = 1.7 µM) and much weaker inhibition of dopamine reuptake (IC50 >10 µM).{22912} Moreover, hydroxyl bupropion isomers are potent antagonists of nicotinic receptors, suggesting that they may substitute for bupropion in smoking cessation.{22912,22911,22909}
Brand:CaymanSKU:9000522 - 10 mgAvailable on backorder
Buproprion (Item No. 10488) is an inhibitor of the reuptake of dopamine and norepinephrine and is also an antagonist of neuronal acetylcholine nicotinic receptors. Because of its effects on nicotinic receptors, it is used to promote smoking cessation. Hydroxy bupropion is a mixture of enantiomers produced by the metabolism of buproprion by cytochrome P450 2B6.{22910,22909} Compared with buproprion, this racemic mixture produces equal inhibition of norepinephrine reuptake (IC50 = 1.7 µM) and much weaker inhibition of dopamine reuptake (IC50 >10 µM).{22912} Moreover, hydroxyl bupropion isomers are potent antagonists of nicotinic receptors, suggesting that they may substitute for bupropion in smoking cessation.{22912,22911,22909}
Brand:CaymanSKU:9000522 - 5 mgAvailable on backorder
Dimetridazole is a nitroimidazole-based compound with antibacterial and anticoccidial activity.{26702} It was once widely used in the treatment of parasitic infections in poultry, cattle, swine and farmed fish until suspected to be carcinogenic and mutagenic to humans.{26704} Hydroxy dimetridazole is a metabolite of dimetridazole that may be useful for identifying this nitroimidazole in various agricultural samples through liquid chromatography–tandem mass spectrometry and other methods.{26704,26705,26703}
Brand:CaymanSKU:- Dimetridazole is a nitroimidazole-based compound with antibacterial and anticoccidial activity.{26702} It was once widely used in the treatment of parasitic infections in poultry, cattle, swine and farmed fish until suspected to be carcinogenic and mutagenic to humans.{26704} Hydroxy dimetridazole is a metabolite of dimetridazole that may be useful for identifying this nitroimidazole in various agricultural samples through liquid chromatography–tandem mass spectrometry and other methods.{26704,26705,26703}
Brand:CaymanSKU:- Dimetridazole is a nitroimidazole-based compound with antibacterial and anticoccidial activity.{26702} It was once widely used in the treatment of parasitic infections in poultry, cattle, swine and farmed fish until suspected to be carcinogenic and mutagenic to humans.{26704} Hydroxy dimetridazole is a metabolite of dimetridazole that may be useful for identifying this nitroimidazole in various agricultural samples through liquid chromatography–tandem mass spectrometry and other methods.{26704,26705,26703}
Brand:CaymanSKU:- Dimetridazole is a nitroimidazole-based compound with antibacterial and anticoccidial activity.{26702} It was once widely used in the treatment of parasitic infections in poultry, cattle, swine and farmed fish until suspected to be carcinogenic and mutagenic to humans.{26704} Hydroxy dimetridazole is a metabolite of dimetridazole that may be useful for identifying this nitroimidazole in various agricultural samples through liquid chromatography–tandem mass spectrometry and other methods.{26704,26705,26703}
Brand:CaymanSKU:-
Hydroxy itraconazole (OH-ITZ) is an active metabolite of the antifungal agent itraconazole (Item No. 13288). Itraconazole is metabolized by the cytochrome P450 isoform 3A4 (CYP3A4) to form hydroxy itraconazole. Hydroxy itraconazole exhibits in vitro antifungal activity (MIC = 0.019, 0.078, and 0.078 mg/ml against C. albicans, A. fumigatus, and C. neoformans, respectively).{35028} Plasma concentration of hydroxy itraconazole is directly correlated to that of the parent compound and is used as an indicator of prophylaxis for fungal infections.{35029}
Brand:CaymanSKU:22576 -Out of stock
Hydroxy itraconazole (OH-ITZ) is an active metabolite of the antifungal agent itraconazole (Item No. 13288). Itraconazole is metabolized by the cytochrome P450 isoform 3A4 (CYP3A4) to form hydroxy itraconazole. Hydroxy itraconazole exhibits in vitro antifungal activity (MIC = 0.019, 0.078, and 0.078 mg/ml against C. albicans, A. fumigatus, and C. neoformans, respectively).{35028} Plasma concentration of hydroxy itraconazole is directly correlated to that of the parent compound and is used as an indicator of prophylaxis for fungal infections.{35029}
Brand:CaymanSKU:22576 -Out of stock
Hydroxy pioglitazone is a major metabolite of the peroxisome proliferator-activated receptor γ (PPARγ) agonist pioglitazone (Item Nos. 71745 | 22263 | 10028).{48274} It is formed from pioglitazone by the cytochrome P450 (CYP) isoform CYP2C8 with minor contributions from CYP3A4.{48275} Hydroxy pioglitazone binds to PPARγ (Ki = 1.2 μM) and activates PPARγ in a time-resolved FRET (TR-FRET) assay (EC50 = 2.1 μM).{48274}
Brand:CaymanSKU:28043 - 1 mgAvailable on backorder
Hydroxy pioglitazone is a major metabolite of the peroxisome proliferator-activated receptor γ (PPARγ) agonist pioglitazone (Item Nos. 71745 | 22263 | 10028).{48274} It is formed from pioglitazone by the cytochrome P450 (CYP) isoform CYP2C8 with minor contributions from CYP3A4.{48275} Hydroxy pioglitazone binds to PPARγ (Ki = 1.2 μM) and activates PPARγ in a time-resolved FRET (TR-FRET) assay (EC50 = 2.1 μM).{48274}
Brand:CaymanSKU:28043 - 5 mgAvailable on backorder
Hydroxy varenicline is a metabolite of the nicotinic acetylcholine receptor (nAChR) agonist varenicline (Item No. 15030).{46370}
Brand:CaymanSKU:22388 -Out of stock
Hydroxy varenicline is a metabolite of the nicotinic acetylcholine receptor (nAChR) agonist varenicline (Item No. 15030).{46370}
Brand:CaymanSKU:22388 -Out of stock
Hydroxy varenicline is a metabolite of the nicotinic acetylcholine receptor (nAChR) agonist varenicline (Item No. 15030).{46370}
Brand:CaymanSKU:22388 -Out of stock
Hydroxy varenicline is a metabolite of the nicotinic acetylcholine receptor (nAChR) agonist varenicline (Item No. 15030).{46370}
Brand:CaymanSKU:22388 -Out of stock
Hydroxychlorodenafil is a derivative of the phosphodiesterase 5 (PDE5) inhibitor sildenafil (Item No. 10008671).{49689}
Brand:CaymanSKU:29998 - 100 mgAvailable on backorder
Hydroxychlorodenafil is a derivative of the phosphodiesterase 5 (PDE5) inhibitor sildenafil (Item No. 10008671).{49689}
Brand:CaymanSKU:29998 - 50 mgAvailable on backorder
Hydroxychloroquine is an aminoquinoline with antimalarial, anti-inflammatory, and antiviral activities.{61135,48566,61136,61137} It is active against the chloroquine-sensitive NF54 and D6 strains of P. falciparum (IC50s = 16.3 and 15 nM, respectively) but has decreased activity against chloroquine-resistant P. falciparum strains (IC50s = 422.7-1,735.3 nM).{61135} Hydroxychloroquine inhibits production of IL-22, IL-17A, and IL-6 induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) and ionomycin (Item No. 10004974) in peripheral blood mononuclear cells (PBMCs) isolated from healthy individuals or patients with systemic lupus erythematosus (SLE) or rheumatoid arthritis (RA).{61136} It inhibits accumulation of sequestosome-1 (SQSTM1) puncta, a marker of autophagy, in mouse embryonic fibroblasts (MEFs) in a concentration-dependent manner.{48566} Hydroxychloroquine reduces viral titers of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the culture supernatant of infected Vero E6 cells but does not reduce SARS-CoV-2 viral titers in an in vitro human airway epithelium model or the respiratory tract of infected cynomolgus macaques.{61137} Formulations containing hydroxychloroquine have been used in the prevention or treatment of malaria, as well as in the treatment of RA and SLE.
Brand:CaymanSKU:-Available on backorder
Hydroxychloroquine is an aminoquinoline with antimalarial, anti-inflammatory, and antiviral activities.{61135,48566,61136,61137} It is active against the chloroquine-sensitive NF54 and D6 strains of P. falciparum (IC50s = 16.3 and 15 nM, respectively) but has decreased activity against chloroquine-resistant P. falciparum strains (IC50s = 422.7-1,735.3 nM).{61135} Hydroxychloroquine inhibits production of IL-22, IL-17A, and IL-6 induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) and ionomycin (Item No. 10004974) in peripheral blood mononuclear cells (PBMCs) isolated from healthy individuals or patients with systemic lupus erythematosus (SLE) or rheumatoid arthritis (RA).{61136} It inhibits accumulation of sequestosome-1 (SQSTM1) puncta, a marker of autophagy, in mouse embryonic fibroblasts (MEFs) in a concentration-dependent manner.{48566} Hydroxychloroquine reduces viral titers of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the culture supernatant of infected Vero E6 cells but does not reduce SARS-CoV-2 viral titers in an in vitro human airway epithelium model or the respiratory tract of infected cynomolgus macaques.{61137} Formulations containing hydroxychloroquine have been used in the prevention or treatment of malaria, as well as in the treatment of RA and SLE.
Brand:CaymanSKU:-Available on backorder
Hydroxychloroquine is an aminoquinoline with antimalarial, anti-inflammatory, and antiviral activities.{61135,48566,61136,61137} It is active against the chloroquine-sensitive NF54 and D6 strains of P. falciparum (IC50s = 16.3 and 15 nM, respectively) but has decreased activity against chloroquine-resistant P. falciparum strains (IC50s = 422.7-1,735.3 nM).{61135} Hydroxychloroquine inhibits production of IL-22, IL-17A, and IL-6 induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) and ionomycin (Item No. 10004974) in peripheral blood mononuclear cells (PBMCs) isolated from healthy individuals or patients with systemic lupus erythematosus (SLE) or rheumatoid arthritis (RA).{61136} It inhibits accumulation of sequestosome-1 (SQSTM1) puncta, a marker of autophagy, in mouse embryonic fibroblasts (MEFs) in a concentration-dependent manner.{48566} Hydroxychloroquine reduces viral titers of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the culture supernatant of infected Vero E6 cells but does not reduce SARS-CoV-2 viral titers in an in vitro human airway epithelium model or the respiratory tract of infected cynomolgus macaques.{61137} Formulations containing hydroxychloroquine have been used in the prevention or treatment of malaria, as well as in the treatment of RA and SLE.
Brand:CaymanSKU:-Available on backorder
Hydroxychloroquine is an aminoquinoline with antimalarial, anti-inflammatory, and antiviral activities.{61135,48566,61136,61137} It is active against the chloroquine-sensitive NF54 and D6 strains of P. falciparum (IC50s = 16.3 and 15 nM, respectively) but has decreased activity against chloroquine-resistant P. falciparum strains (IC50s = 422.7-1,735.3 nM).{61135} Hydroxychloroquine inhibits production of IL-22, IL-17A, and IL-6 induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) and ionomycin (Item No. 10004974) in peripheral blood mononuclear cells (PBMCs) isolated from healthy individuals or patients with systemic lupus erythematosus (SLE) or rheumatoid arthritis (RA).{61136} It inhibits accumulation of sequestosome-1 (SQSTM1) puncta, a marker of autophagy, in mouse embryonic fibroblasts (MEFs) in a concentration-dependent manner.{48566} Hydroxychloroquine reduces viral titers of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the culture supernatant of infected Vero E6 cells but does not reduce SARS-CoV-2 viral titers in an in vitro human airway epithelium model or the respiratory tract of infected cynomolgus macaques.{61137} Formulations containing hydroxychloroquine have been used in the prevention or treatment of malaria, as well as in the treatment of RA and SLE.
Brand:CaymanSKU:-Available on backorder
Hydroxychloroquine-d4 (sulfate) is intended for use as an internal standard for the quantification of hydroxychloroquine (Item No. 17911) by GC- or LC-MS. Hydroxychloroquine is an aminoquinoline with antimalarial, anti-inflammatory, and antiviral activities.{61135,48566,61136,61137} It is active against the chloroquine-sensitive NF54 and D6 strains of P. falciparum (IC50s = 16.3 and 15 nM, respectively) but has decreased activity against chloroquine-resistant P. falciparum strains (IC50s = 422.7-1,735.3 nM).{61135} Hydroxychloroquine inhibits production of IL-22, IL-17A, and IL-6 induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) and ionomycin (Item No. 10004974) in peripheral blood mononuclear cells (PBMCs) isolated from healthy individuals or patients with systemic lupus erythematosus (SLE) or rheumatoid arthritis (RA).{61163} It inhibits accumulation of sequestosome-1 (SQSTM1) puncta, a marker of autophagy, in mouse embryonic fibroblasts (MEFs) in a concentration-dependent manner.{48566} Hydroxychloroquine reduces viral titers of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the culture supernatant of infected Vero E6 cells but does not reduce SARS-CoV-2 viral titers in an in vitro human airway epithelium model or the respiratory tract of infected cynomolgus macaques.{61137} Formulations containing hydroxychloroquine have been used in the prevention or treatment of malaria, as well as in the treatment of RA and SLE.
Brand:CaymanSKU:22375 -Out of stock
Hydroxychloroquine-d4 (sulfate) is intended for use as an internal standard for the quantification of hydroxychloroquine (Item No. 17911) by GC- or LC-MS. Hydroxychloroquine is an aminoquinoline with antimalarial, anti-inflammatory, and antiviral activities.{61135,48566,61136,61137} It is active against the chloroquine-sensitive NF54 and D6 strains of P. falciparum (IC50s = 16.3 and 15 nM, respectively) but has decreased activity against chloroquine-resistant P. falciparum strains (IC50s = 422.7-1,735.3 nM).{61135} Hydroxychloroquine inhibits production of IL-22, IL-17A, and IL-6 induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) and ionomycin (Item No. 10004974) in peripheral blood mononuclear cells (PBMCs) isolated from healthy individuals or patients with systemic lupus erythematosus (SLE) or rheumatoid arthritis (RA).{61163} It inhibits accumulation of sequestosome-1 (SQSTM1) puncta, a marker of autophagy, in mouse embryonic fibroblasts (MEFs) in a concentration-dependent manner.{48566} Hydroxychloroquine reduces viral titers of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the culture supernatant of infected Vero E6 cells but does not reduce SARS-CoV-2 viral titers in an in vitro human airway epithelium model or the respiratory tract of infected cynomolgus macaques.{61137} Formulations containing hydroxychloroquine have been used in the prevention or treatment of malaria, as well as in the treatment of RA and SLE.
Brand:CaymanSKU:22375 -Out of stock
Hydroxyebastine is an ebastine (Item No. 15372) metabolite.{24986,34756} Ebastine undergoes rapid first-pass metabolism by the cytochrome P450 isoform CYP2J2 to form hydroxyebastine which is then metabolized by CYP2J2 and CYP3A4 to form carebastine.
Brand:CaymanSKU:22379 -Out of stock
Hydroxyebastine is an ebastine (Item No. 15372) metabolite.{24986,34756} Ebastine undergoes rapid first-pass metabolism by the cytochrome P450 isoform CYP2J2 to form hydroxyebastine which is then metabolized by CYP2J2 and CYP3A4 to form carebastine.
Brand:CaymanSKU:22379 -Out of stock
Hydroxylupanine is an alkaloid that has been found in L. lanatus.{54186} It is an inhibitor of ganglionic transmission.{54187}
Brand:CaymanSKU:31171 - 1 mgAvailable on backorder
Hydroxymethyl uracil is a product of oxidative damage to DNA, predominantly by hydroxyl radical via the Fenton reaction.{2506,2239,2240}
Brand:CaymanSKU:89360 - 1 gAvailable on backorder
Hydroxymethyl uracil is a product of oxidative damage to DNA, predominantly by hydroxyl radical via the Fenton reaction.{2506,2239,2240}
Brand:CaymanSKU:89360 - 10 gAvailable on backorder
Hydroxymethyl uracil is a product of oxidative damage to DNA, predominantly by hydroxyl radical via the Fenton reaction.{2506,2239,2240}
Brand:CaymanSKU:89360 - 250 mgAvailable on backorder
Hydroxymethyl uracil is a product of oxidative damage to DNA, predominantly by hydroxyl radical via the Fenton reaction.{2506,2239,2240}
Brand:CaymanSKU:89360 - 5 gAvailable on backorder
Hydroxyprogesterone caproate is a synthetic progestogen.{39556} In vivo, hydroxyprogesterone caproate (3.32 mg/kg) reduces TNF-α-induced hypertension and decreases renal endothelin-1 (ET-1) production in pregnant rats. It reduces hypertension and production of TNF-α and IL-6 induced by reduction in uteroplacental perfusion (RUPP) in pregnant rats.{39557} Hydroxyprogesterone caproate also prevents preterm birth induced by L-NAME (Item No. 80210) in pregnant mice.{39558} Formulations containing hydroxyprogesterone caproate have been used for the prevention of preterm birth.
Brand:CaymanSKU:23978 - 100 mgAvailable on backorder
Hydroxyprogesterone caproate is a synthetic progestogen.{39556} In vivo, hydroxyprogesterone caproate (3.32 mg/kg) reduces TNF-α-induced hypertension and decreases renal endothelin-1 (ET-1) production in pregnant rats. It reduces hypertension and production of TNF-α and IL-6 induced by reduction in uteroplacental perfusion (RUPP) in pregnant rats.{39557} Hydroxyprogesterone caproate also prevents preterm birth induced by L-NAME (Item No. 80210) in pregnant mice.{39558} Formulations containing hydroxyprogesterone caproate have been used for the prevention of preterm birth.
Brand:CaymanSKU:23978 - 250 mgAvailable on backorder
Hydroxyprogesterone caproate is a synthetic progestogen.{39556} In vivo, hydroxyprogesterone caproate (3.32 mg/kg) reduces TNF-α-induced hypertension and decreases renal endothelin-1 (ET-1) production in pregnant rats. It reduces hypertension and production of TNF-α and IL-6 induced by reduction in uteroplacental perfusion (RUPP) in pregnant rats.{39557} Hydroxyprogesterone caproate also prevents preterm birth induced by L-NAME (Item No. 80210) in pregnant mice.{39558} Formulations containing hydroxyprogesterone caproate have been used for the prevention of preterm birth.
Brand:CaymanSKU:23978 - 500 mgAvailable on backorder
Hydroxysafflor yellow A is a pigment that has been found in C. tinctorius and has diverse biological activities.{52728,52729,52730,52731} It inhibits LPS-induced increases in NF-κB levels and production of nitric oxide (NO), IL-1β, and TNF-α in primary mouse embryonic mesencephalic cultures when used at concentrations of 40 and 160 µM.{52729} Hydroxysafflor yellow A (1 and 3 mg/kg) decreases mean arterial pressure (MAP) and heart rate in anesthetized normotensive or spontaneously hypertensive rats.{52730} It reduces infarct volume and serum superoxide dismutase (SOD) activity in a rat model of focal transient cerebral ischemia induced by middle cerebral artery occlusion (MCAO) when administered at doses of 2, 4, and 8 mg/kg.{52731}
Brand:CaymanSKU:31204 - 1 mgAvailable on backorder
Hydroxysafflor yellow A is a pigment that has been found in C. tinctorius and has diverse biological activities.{52728,52729,52730,52731} It inhibits LPS-induced increases in NF-κB levels and production of nitric oxide (NO), IL-1β, and TNF-α in primary mouse embryonic mesencephalic cultures when used at concentrations of 40 and 160 µM.{52729} Hydroxysafflor yellow A (1 and 3 mg/kg) decreases mean arterial pressure (MAP) and heart rate in anesthetized normotensive or spontaneously hypertensive rats.{52730} It reduces infarct volume and serum superoxide dismutase (SOD) activity in a rat model of focal transient cerebral ischemia induced by middle cerebral artery occlusion (MCAO) when administered at doses of 2, 4, and 8 mg/kg.{52731}
Brand:CaymanSKU:31204 - 10 mgAvailable on backorder
Hydroxysafflor yellow A is a pigment that has been found in C. tinctorius and has diverse biological activities.{52728,52729,52730,52731} It inhibits LPS-induced increases in NF-κB levels and production of nitric oxide (NO), IL-1β, and TNF-α in primary mouse embryonic mesencephalic cultures when used at concentrations of 40 and 160 µM.{52729} Hydroxysafflor yellow A (1 and 3 mg/kg) decreases mean arterial pressure (MAP) and heart rate in anesthetized normotensive or spontaneously hypertensive rats.{52730} It reduces infarct volume and serum superoxide dismutase (SOD) activity in a rat model of focal transient cerebral ischemia induced by middle cerebral artery occlusion (MCAO) when administered at doses of 2, 4, and 8 mg/kg.{52731}
Brand:CaymanSKU:31204 - 5 mgAvailable on backorder
Hydroxystilbamidine is a fluorescent neuronal retrograde tracer that labels the neuronal cell body as well as proximal dendrites.{42600,42602} Hydroxystilbamidine, when visualized in tissue sections, displays excitation/emission maxima of 323/620 nm, respectively. It is also a nucleic acid dye that can be used to label DNA and RNA in fixed or unfixed dead cells.{42601} It displays an excitation maximum of 360 nm and emission maxima of 450 and 600 nm when bound to DNA but only emits at 450 nm when bound to RNA.
Brand:CaymanSKU:26858 - 10 mgAvailable on backorder
Hydroxystilbamidine is a fluorescent neuronal retrograde tracer that labels the neuronal cell body as well as proximal dendrites.{42600,42602} Hydroxystilbamidine, when visualized in tissue sections, displays excitation/emission maxima of 323/620 nm, respectively. It is also a nucleic acid dye that can be used to label DNA and RNA in fixed or unfixed dead cells.{42601} It displays an excitation maximum of 360 nm and emission maxima of 450 and 600 nm when bound to DNA but only emits at 450 nm when bound to RNA.
Brand:CaymanSKU:26858 - 5 mgAvailable on backorder
Hydroxysulochrin is a fungal metabolite and plant growth regulator that has been found in Aureobasidium.{52431} It inhibits tea (C. sinensis) pollen tube growth by 41%, but does not inhibit lettuce (L. sativa) seedling root growth, when used at a concentration of 100 mg/L.
Brand:CaymanSKU:29325 - 1 mgAvailable on backorder
Hydroxytacrine is a bioactive monohydroxylated metabolite of the cholinesterase inhibitor, tacrine (Item No. 70240), produced by cytochrome P450 1A-catalyzed hydroxylation.{30767} While tacrine has been used clinically in the treatment of Alzheimer’s disease, its prolonged use is associated with liver toxicity.{17054,6603} Hydroxytacrine demonstrates similar anticholinesterase activity to tacrine, yet has less acute toxicity in both animal and clinical studies of Alzheimer’s disease.{30768,30766}
Brand:CaymanSKU:-Available on backorder
Hydroxytacrine is a bioactive monohydroxylated metabolite of the cholinesterase inhibitor, tacrine (Item No. 70240), produced by cytochrome P450 1A-catalyzed hydroxylation.{30767} While tacrine has been used clinically in the treatment of Alzheimer’s disease, its prolonged use is associated with liver toxicity.{17054,6603} Hydroxytacrine demonstrates similar anticholinesterase activity to tacrine, yet has less acute toxicity in both animal and clinical studies of Alzheimer’s disease.{30768,30766}
Brand:CaymanSKU:-Available on backorder
Hydroxytacrine is a bioactive monohydroxylated metabolite of the cholinesterase inhibitor, tacrine (Item No. 70240), produced by cytochrome P450 1A-catalyzed hydroxylation.{30767} While tacrine has been used clinically in the treatment of Alzheimer’s disease, its prolonged use is associated with liver toxicity.{17054,6603} Hydroxytacrine demonstrates similar anticholinesterase activity to tacrine, yet has less acute toxicity in both animal and clinical studies of Alzheimer’s disease.{30768,30766}
Brand:CaymanSKU:-Available on backorder
Hydroxyurea is an antineoplastic agent that inhibits DNA replication and cell proliferation and induces cell cycle arrest in the G1/S phase.{38524} It inhibits proliferation of NCI H460 human lung cancer cells in vitro (IC50 = 0.56 mM).{38533} Hydroxyurea reduces ribonucleoside diphosphate reductase (RNR) activity by 75% when used at a concentration of 5 mM via degradation of its active site tyrosyl radical.{38524,38534} In a humanized mouse model of sickle cell disease (SCD), it reduces leukocyte adhesion and extravasation via NO production and a cGMP-dependent pathway.{38535} Hydroxyurea also inhibits HIV-1 viral replication in peripheral blood mononuclear cells (PBMCs) in a dose-dependent manner with an IC90 value of 0.4 mM.{38536,38528} Formulations containing hydroxyurea have been used to treat cancer, SCD, and psoriasis.{38524,38525,38527}
Brand:CaymanSKU:23725 - 10 gAvailable on backorder
Hydroxyurea is an antineoplastic agent that inhibits DNA replication and cell proliferation and induces cell cycle arrest in the G1/S phase.{38524} It inhibits proliferation of NCI H460 human lung cancer cells in vitro (IC50 = 0.56 mM).{38533} Hydroxyurea reduces ribonucleoside diphosphate reductase (RNR) activity by 75% when used at a concentration of 5 mM via degradation of its active site tyrosyl radical.{38524,38534} In a humanized mouse model of sickle cell disease (SCD), it reduces leukocyte adhesion and extravasation via NO production and a cGMP-dependent pathway.{38535} Hydroxyurea also inhibits HIV-1 viral replication in peripheral blood mononuclear cells (PBMCs) in a dose-dependent manner with an IC90 value of 0.4 mM.{38536,38528} Formulations containing hydroxyurea have been used to treat cancer, SCD, and psoriasis.{38524,38525,38527}
Brand:CaymanSKU:23725 - 25 gAvailable on backorder
Hydroxyurea is an antineoplastic agent that inhibits DNA replication and cell proliferation and induces cell cycle arrest in the G1/S phase.{38524} It inhibits proliferation of NCI H460 human lung cancer cells in vitro (IC50 = 0.56 mM).{38533} Hydroxyurea reduces ribonucleoside diphosphate reductase (RNR) activity by 75% when used at a concentration of 5 mM via degradation of its active site tyrosyl radical.{38524,38534} In a humanized mouse model of sickle cell disease (SCD), it reduces leukocyte adhesion and extravasation via NO production and a cGMP-dependent pathway.{38535} Hydroxyurea also inhibits HIV-1 viral replication in peripheral blood mononuclear cells (PBMCs) in a dose-dependent manner with an IC90 value of 0.4 mM.{38536,38528} Formulations containing hydroxyurea have been used to treat cancer, SCD, and psoriasis.{38524,38525,38527}
Brand:CaymanSKU:23725 - 5 gAvailable on backorder
Hydroxyurea is an antineoplastic agent that inhibits DNA replication and cell proliferation and induces cell cycle arrest in the G1/S phase.{38524} It inhibits proliferation of NCI H460 human lung cancer cells in vitro (IC50 = 0.56 mM).{38533} Hydroxyurea reduces ribonucleoside diphosphate reductase (RNR) activity by 75% when used at a concentration of 5 mM via degradation of its active site tyrosyl radical.{38524,38534} In a humanized mouse model of sickle cell disease (SCD), it reduces leukocyte adhesion and extravasation via NO production and a cGMP-dependent pathway.{38535} Hydroxyurea also inhibits HIV-1 viral replication in peripheral blood mononuclear cells (PBMCs) in a dose-dependent manner with an IC90 value of 0.4 mM.{38536,38528} Formulations containing hydroxyurea have been used to treat cancer, SCD, and psoriasis.{38524,38525,38527}
Brand:CaymanSKU:23725 - 50 gAvailable on backorder
Hydroxyzine is a histamine H1 receptor antagonist (Ki = 1.9 nM).{39568} It binds competitively with the H1 receptor inverse agonist mepyramine (Item No. 20978) with an IC50 value of 80 µM in polymorphonuclear leukocytes.{39569} In vivo, it is metabolized to the H1 receptor antagonist cetirizine (Item No. 19686).{40229} In situ, hydroxyzine (10 µM) prevents recruitment of rolling leukocytes induced by histamine in rat mesentery post-capillary venules.{39570} Hydroxyzine also decreases anxiety-like behavior in mice, increasing the time spent in the open arms of the elevated plus maze and in the light side of the light-dark exploration test.{39571} Formulations containing hydroxyzine have been used in the treatment of anxiety and as antihistamines in the treatment of allergic rhinitis.
Brand:CaymanSKU:24039 - 100 mgAvailable on backorder
Hydroxyzine is a histamine H1 receptor antagonist (Ki = 1.9 nM).{39568} It binds competitively with the H1 receptor inverse agonist mepyramine (Item No. 20978) with an IC50 value of 80 µM in polymorphonuclear leukocytes.{39569} In vivo, it is metabolized to the H1 receptor antagonist cetirizine (Item No. 19686).{40229} In situ, hydroxyzine (10 µM) prevents recruitment of rolling leukocytes induced by histamine in rat mesentery post-capillary venules.{39570} Hydroxyzine also decreases anxiety-like behavior in mice, increasing the time spent in the open arms of the elevated plus maze and in the light side of the light-dark exploration test.{39571} Formulations containing hydroxyzine have been used in the treatment of anxiety and as antihistamines in the treatment of allergic rhinitis.
Brand:CaymanSKU:24039 - 250 mgAvailable on backorder
Hydroxyzine is a histamine H1 receptor antagonist (Ki = 1.9 nM).{39568} It binds competitively with the H1 receptor inverse agonist mepyramine (Item No. 20978) with an IC50 value of 80 µM in polymorphonuclear leukocytes.{39569} In vivo, it is metabolized to the H1 receptor antagonist cetirizine (Item No. 19686).{40229} In situ, hydroxyzine (10 µM) prevents recruitment of rolling leukocytes induced by histamine in rat mesentery post-capillary venules.{39570} Hydroxyzine also decreases anxiety-like behavior in mice, increasing the time spent in the open arms of the elevated plus maze and in the light side of the light-dark exploration test.{39571} Formulations containing hydroxyzine have been used in the treatment of anxiety and as antihistamines in the treatment of allergic rhinitis.
Brand:CaymanSKU:24039 - 500 mgAvailable on backorder
Hydroxyzine-d8 is intended for use as an internal standard for the quantification of hydroxyzine (Item No. 24039) by GC- or LC-MS. Hydroxyzine is a histamine H1 receptor antagonist (Ki = 1.9 nM).{39568} It binds competitively with the H1 receptor inverse agonist mepyramine (Item No. 20978) with an IC50 value of 80 µM in polymorphonuclear leukocytes.{39569} In vivo, it is metabolized to the H1 receptor antagonist cetirizine (Item No. 19686).{40229} In situ, hydroxyzine (10 µM) prevents recruitment of rolling leukocytes induced by histamine in rat mesentery post-capillary venules.{39570} Hydroxyzine also decreases anxiety-like behavior in mice, increasing the time spent in the open arms of the elevated plus maze and in the light side of the light-dark exploration test.{39571} Formulations containing hydroxyzine have been used in the treatment of anxiety and as antihistamines in the treatment of allergic rhinitis.
Brand:CaymanSKU:30739 - 1 mgAvailable on backorder
Hygrolidin is a macrocyclic lactone originally isolated from S. hygroscopicus.{46280} It inhibits proliferation of a variety of cancer cell lines, including DLD-1 colon cancer, LNCaP prostate cancer, and K562 leukemia cells (IC50s = 2.9, 5.2, and 33 ng/ml, respectively).{46281} Hygrolidin induces the expression and levels of p21 in DLD-1 cells, but not WI-38 fibroblasts, and leads to cell accumulation in the G1 and S phases without inducing apoptosis. It has antiparasitic activity against T. cruzi, L. donovani, and T. b. brucei but also induces cytotoxicity in HepG2 cells (IC50s = 1.1, 72.5, 77, and 24.5 nM, respectively).{46282}
Brand:CaymanSKU:28116 - 1 mgAvailable on backorder
Hygrolidin is a macrocyclic lactone originally isolated from S. hygroscopicus.{46280} It inhibits proliferation of a variety of cancer cell lines, including DLD-1 colon cancer, LNCaP prostate cancer, and K562 leukemia cells (IC50s = 2.9, 5.2, and 33 ng/ml, respectively).{46281} Hygrolidin induces the expression and levels of p21 in DLD-1 cells, but not WI-38 fibroblasts, and leads to cell accumulation in the G1 and S phases without inducing apoptosis. It has antiparasitic activity against T. cruzi, L. donovani, and T. b. brucei but also induces cytotoxicity in HepG2 cells (IC50s = 1.1, 72.5, 77, and 24.5 nM, respectively).{46282}
Brand:CaymanSKU:28116 - 5 mgAvailable on backorder
Hygromycin B is an antibiotic which is used in molecular and cell biology to select for transformed cells expressing the hygromycin resistance gene.{22697,22695} It is an aminoglycoside produced by the bacterium S. hygroscopicus which kills prokaryotic and eukaryotic cells by inhibiting protein synthesis.{22696,22442} The hygromycin resistance gene (hyg or hph) encodes a phosphotransferase which inhibits hygromycin through phosphorylation.{22695}
Brand:CaymanSKU:- Hygromycin B is an antibiotic which is used in molecular and cell biology to select for transformed cells expressing the hygromycin resistance gene.{22697,22695} It is an aminoglycoside produced by the bacterium S. hygroscopicus which kills prokaryotic and eukaryotic cells by inhibiting protein synthesis.{22696,22442} The hygromycin resistance gene (hyg or hph) encodes a phosphotransferase which inhibits hygromycin through phosphorylation.{22695}
Brand:CaymanSKU:-
Hymeglusin is a fungal β-lactone antibiotic that inhibits HMG-CoA synthase (IC50 = 0.12 μM) by covalently modifying the active Cys129 residue of the enzyme.{21712,21710} At a dose of 25 mg/kg, hymeglusin inhibits cholesterol biosynthesis in rats by 45%.{21712} Chiral studies indicate that the (2R,3R)-β-lactone moiety of hymeglusin is important for eliciting the specific inhibition of HMG-CoA synthase.{21713} As a cell-wall targeting antibiotic, hymeglusin has been used to investigate the role of a gene important for controlling S. aureus virulence in a mouse sepsis model of infection.{21711}
Brand:CaymanSKU:11899 - 1 mgAvailable on backorder
Hymeglusin is a fungal β-lactone antibiotic that inhibits HMG-CoA synthase (IC50 = 0.12 μM) by covalently modifying the active Cys129 residue of the enzyme.{21712,21710} At a dose of 25 mg/kg, hymeglusin inhibits cholesterol biosynthesis in rats by 45%.{21712} Chiral studies indicate that the (2R,3R)-β-lactone moiety of hymeglusin is important for eliciting the specific inhibition of HMG-CoA synthase.{21713} As a cell-wall targeting antibiotic, hymeglusin has been used to investigate the role of a gene important for controlling S. aureus virulence in a mouse sepsis model of infection.{21711}
Brand:CaymanSKU:11899 - 2.5 mgAvailable on backorder
Hymeglusin is a fungal β-lactone antibiotic that inhibits HMG-CoA synthase (IC50 = 0.12 μM) by covalently modifying the active Cys129 residue of the enzyme.{21712,21710} At a dose of 25 mg/kg, hymeglusin inhibits cholesterol biosynthesis in rats by 45%.{21712} Chiral studies indicate that the (2R,3R)-β-lactone moiety of hymeglusin is important for eliciting the specific inhibition of HMG-CoA synthase.{21713} As a cell-wall targeting antibiotic, hymeglusin has been used to investigate the role of a gene important for controlling S. aureus virulence in a mouse sepsis model of infection.{21711}
Brand:CaymanSKU:11899 - 500 µgAvailable on backorder
Hyocholic acid is a primary bile acid in pigs and other mammals.{34513} It has also been found in urine samples from patients with cholestasis.{43817} Hyocholic acid is converted by gut microflora primarily to taurohyocholate and, to a lesser extent, taurocholic acid (Item No. 16215) and tauro-β-muricholic acid (Item No. 20289) in mice.{34515} Hyocholic acid has low toxicity against human hepatoma HepG2 cells.{34515,34514}
Brand:CaymanSKU:20293 -Available on backorder
Hyocholic acid is a primary bile acid in pigs and other mammals.{34513} It has also been found in urine samples from patients with cholestasis.{43817} Hyocholic acid is converted by gut microflora primarily to taurohyocholate and, to a lesser extent, taurocholic acid (Item No. 16215) and tauro-β-muricholic acid (Item No. 20289) in mice.{34515} Hyocholic acid has low toxicity against human hepatoma HepG2 cells.{34515,34514}
Brand:CaymanSKU:20293 -Available on backorder
Hyocholic acid is a primary bile acid in pigs and other mammals.{34513} It has also been found in urine samples from patients with cholestasis.{43817} Hyocholic acid is converted by gut microflora primarily to taurohyocholate and, to a lesser extent, taurocholic acid (Item No. 16215) and tauro-β-muricholic acid (Item No. 20289) in mice.{34515} Hyocholic acid has low toxicity against human hepatoma HepG2 cells.{34515,34514}
Brand:CaymanSKU:20293 -Available on backorder
Hyocholic acid is a primary bile acid in pigs and other mammals.{34513} It has also been found in urine samples from patients with cholestasis.{43817} Hyocholic acid is converted by gut microflora primarily to taurohyocholate and, to a lesser extent, taurocholic acid (Item No. 16215) and tauro-β-muricholic acid (Item No. 20289) in mice.{34515} Hyocholic acid has low toxicity against human hepatoma HepG2 cells.{34515,34514}
Brand:CaymanSKU:20293 -Available on backorder
Hyodeoxycholic acid (HDCA) is a secondary bile acid.{33390} It is produced from lithocholic acid (Item No. 20253) by gut bacteria.{33390,33392,33395} Dietary administration of HDCA (1.25% w/w) decreases plasma VLDL and LDL cholesterol levels and reduces fasting glucose levels and atherosclerotic lesion size in LDL receptor knockout mice fed a Western diet.{33393} Serum levels of HDCA are increased in patients with Crohn’s disease or ulcerative colitis.{33391}
Brand:CaymanSKU:20294 -Available on backorder
Hyodeoxycholic acid (HDCA) is a secondary bile acid.{33390} It is produced from lithocholic acid (Item No. 20253) by gut bacteria.{33390,33392,33395} Dietary administration of HDCA (1.25% w/w) decreases plasma VLDL and LDL cholesterol levels and reduces fasting glucose levels and atherosclerotic lesion size in LDL receptor knockout mice fed a Western diet.{33393} Serum levels of HDCA are increased in patients with Crohn’s disease or ulcerative colitis.{33391}
Brand:CaymanSKU:20294 -Available on backorder
Hyodeoxycholic acid (HDCA) is a secondary bile acid.{33390} It is produced from lithocholic acid (Item No. 20253) by gut bacteria.{33390,33392,33395} Dietary administration of HDCA (1.25% w/w) decreases plasma VLDL and LDL cholesterol levels and reduces fasting glucose levels and atherosclerotic lesion size in LDL receptor knockout mice fed a Western diet.{33393} Serum levels of HDCA are increased in patients with Crohn’s disease or ulcerative colitis.{33391}
Brand:CaymanSKU:20294 -Available on backorder
Hyodeoxycholic acid (HDCA) is a secondary bile acid.{33390} It is produced from lithocholic acid (Item No. 20253) by gut bacteria.{33390,33392,33395} Dietary administration of HDCA (1.25% w/w) decreases plasma VLDL and LDL cholesterol levels and reduces fasting glucose levels and atherosclerotic lesion size in LDL receptor knockout mice fed a Western diet.{33393} Serum levels of HDCA are increased in patients with Crohn’s disease or ulcerative colitis.{33391}
Brand:CaymanSKU:20294 -Available on backorder
Hyodeoxycholic acid (HDCA) is a secondary bile acid.{33390} It is produced from lithocholic acid (Item No. 20253) by gut bacteria.{33390,33392,33395} Dietary administration of HDCA (1.25% w/w) decreases plasma VLDL and LDL cholesterol levels and reduces fasting glucose levels and atherosclerotic lesion size in LDL receptor knockout mice fed a Western diet.{33393} Serum levels of HDCA are increased in patients with Crohn’s disease or ulcerative colitis.{33391} Hyodeoxycholic acid MaxSpec® standard is a quantitative grade standard of Hyodeoxycholic Acid (Item No. 20294) that has been prepared specifically for mass spectrometry and related applications where quantitative reproducibility is required. The solution has been prepared gravimetrically and is supplied in a deactivated glass ampule sealed under argon. The concentration was verified by comparison to an independently prepared calibration standard. This hyodeoxycholic acid MaxSpec® standard is guaranteed to meet identity, purity, stability, and concentration specifications and is provided with a batch-specific certificate of analysis. Ongoing stability testing is performed to ensure the concentration remains accurate throughout the shelf life of the product. Note: The amount of solution added to the vial is in excess of the listed amount. Therefore, it is necessary to accurately measure volumes for preparation of calibration standards. Follow recommended storage and handling conditions to maintain product quality.
Brand:CaymanSKU:31606 - 100 µgAvailable on backorder
Hypaconitine is a diterpene alkaloid that has been found in Aconitum and has diverse biological activities.{46694,46695} It inhibits nerve stimulation-evoked contractions in isolated mouse phrenic nerve-diaphragm muscle preparations (IC50 = 118 nM).{46694} Hypaconitine (0.025 mg/kg) prevents carrageenan-induced paw edema and reduces acetic acid-induced writhing in mice (ED50 = 0.1 mg/kg).{46695,46696} Hypaconitine is toxic to mice (LD50 = 1.9 mg/kg, s.c.).{46696}
Brand:CaymanSKU:29656 - 10 mgAvailable on backorder
Hypaconitine is a diterpene alkaloid that has been found in Aconitum and has diverse biological activities.{46694,46695} It inhibits nerve stimulation-evoked contractions in isolated mouse phrenic nerve-diaphragm muscle preparations (IC50 = 118 nM).{46694} Hypaconitine (0.025 mg/kg) prevents carrageenan-induced paw edema and reduces acetic acid-induced writhing in mice (ED50 = 0.1 mg/kg).{46695,46696} Hypaconitine is toxic to mice (LD50 = 1.9 mg/kg, s.c.).{46696}
Brand:CaymanSKU:29656 - 25 mgAvailable on backorder
Hypaconitine is a diterpene alkaloid that has been found in Aconitum and has diverse biological activities.{46694,46695} It inhibits nerve stimulation-evoked contractions in isolated mouse phrenic nerve-diaphragm muscle preparations (IC50 = 118 nM).{46694} Hypaconitine (0.025 mg/kg) prevents carrageenan-induced paw edema and reduces acetic acid-induced writhing in mice (ED50 = 0.1 mg/kg).{46695,46696} Hypaconitine is toxic to mice (LD50 = 1.9 mg/kg, s.c.).{46696}
Brand:CaymanSKU:29656 - 5 mgAvailable on backorder
Hypaconitine is a diterpene alkaloid that has been found in Aconitum and has diverse biological activities.{46694,46695} It inhibits nerve stimulation-evoked contractions in isolated mouse phrenic nerve-diaphragm muscle preparations (IC50 = 118 nM).{46694} Hypaconitine (0.025 mg/kg) prevents carrageenan-induced paw edema and reduces acetic acid-induced writhing in mice (ED50 = 0.1 mg/kg).{46695,46696} Hypaconitine is toxic to mice (LD50 = 1.9 mg/kg, s.c.).{46696}
Brand:CaymanSKU:29656 - 50 mgAvailable on backorder
Hyperforin is a natural activator of the steroid X receptor (active at 0.1 to 0.5 µg/ml) and inhibitor of several cytochrome P450 (CYP) isoforms (IC50 = 10 µg/ml for CYP2D6).{9583,9584} It can also inhibit microsomal prostaglandin E2 synthase-1 (mPGES-1; IC50 = 1 µM), 5-lipoxygenase activating protein, and sirtuins.{30723,19457,16291}
Brand:CaymanSKU:19572 -Available on backorder
Hyperforin is a natural activator of the steroid X receptor (active at 0.1 to 0.5 µg/ml) and inhibitor of several cytochrome P450 (CYP) isoforms (IC50 = 10 µg/ml for CYP2D6).{9583,9584} It can also inhibit microsomal prostaglandin E2 synthase-1 (mPGES-1; IC50 = 1 µM), 5-lipoxygenase activating protein, and sirtuins.{30723,19457,16291}
Brand:CaymanSKU:19572 -Available on backorder
An anthroquinone derivative that is naturally found in the flower of H. perforatum (St. John’s wort) and has antidepressant, antiviral, and anticancer activities.{34622,34621} Hypericin inhibits neuronal uptake of serotonin, norepinephrine, dopamine, GABA and L-glutamate, contributing to its antidepressant effects.{34620} It exerts broad spectrum phototoxic affects (IC50 = 140 – 1,570 nM) through induction of apoptotic signaling and formation of reactive oxygen species (ROS) in cancer cells.{34623} Hypericin also has in vitro activity, which can be enhanced with photo-activation, against a variety of viruses including HIV, influenza virus, hepatitis C, murine cytolomegalovirus, and herpes viruses.{34634}
Brand:CaymanSKU:11334 - 1 mgAvailable on backorder
An anthroquinone derivative that is naturally found in the flower of H. perforatum (St. John’s wort) and has antidepressant, antiviral, and anticancer activities.{34622,34621} Hypericin inhibits neuronal uptake of serotonin, norepinephrine, dopamine, GABA and L-glutamate, contributing to its antidepressant effects.{34620} It exerts broad spectrum phototoxic affects (IC50 = 140 – 1,570 nM) through induction of apoptotic signaling and formation of reactive oxygen species (ROS) in cancer cells.{34623} Hypericin also has in vitro activity, which can be enhanced with photo-activation, against a variety of viruses including HIV, influenza virus, hepatitis C, murine cytolomegalovirus, and herpes viruses.{34634}
Brand:CaymanSKU:11334 - 10 mgAvailable on backorder
An anthroquinone derivative that is naturally found in the flower of H. perforatum (St. John’s wort) and has antidepressant, antiviral, and anticancer activities.{34622,34621} Hypericin inhibits neuronal uptake of serotonin, norepinephrine, dopamine, GABA and L-glutamate, contributing to its antidepressant effects.{34620} It exerts broad spectrum phototoxic affects (IC50 = 140 – 1,570 nM) through induction of apoptotic signaling and formation of reactive oxygen species (ROS) in cancer cells.{34623} Hypericin also has in vitro activity, which can be enhanced with photo-activation, against a variety of viruses including HIV, influenza virus, hepatitis C, murine cytolomegalovirus, and herpes viruses.{34634}
Brand:CaymanSKU:11334 - 5 mgAvailable on backorder
An anthroquinone derivative that is naturally found in the flower of H. perforatum (St. John’s wort) and has antidepressant, antiviral, and anticancer activities.{34622,34621} Hypericin inhibits neuronal uptake of serotonin, norepinephrine, dopamine, GABA and L-glutamate, contributing to its antidepressant effects.{34620} It exerts broad spectrum phototoxic affects (IC50 = 140 – 1,570 nM) through induction of apoptotic signaling and formation of reactive oxygen species (ROS) in cancer cells.{34623} Hypericin also has in vitro activity, which can be enhanced with photo-activation, against a variety of viruses including HIV, influenza virus, hepatitis C, murine cytolomegalovirus, and herpes viruses.{34634}
Brand:CaymanSKU:11334 - 500 µgAvailable on backorder
Hypocrellin A is a perylenequinoid that has been found in Shiraia bambusicola and has diverse biological activities.{52379,52380} It is active against C. albicans, C. parapsilosis, and C. tropicalis fungi (IC50s = 0.65, 1, and 85 µg/ml, respectively), as well as S. aureus, methicillin-resistant S. aureus (MRSA), P. aeruginosa, and M. intracellulare bacteria (IC50s = 3, 7, 10, and 2.5 µg/ml, respectively).{52379} Hypocrellin A is also active against L. donovani promastigotes (IC50 = 0.27 µg/ml). Upon photoactivation with UV radiation, hypocrellin A induces production of reactive oxygen species and apoptosis and reduces cell viability of A549 cancer cells.{52380}
Brand:CaymanSKU:29933 - 1 mgAvailable on backorder
Hypocrellin A is a perylenequinoid that has been found in Shiraia bambusicola and has diverse biological activities.{52379,52380} It is active against C. albicans, C. parapsilosis, and C. tropicalis fungi (IC50s = 0.65, 1, and 85 µg/ml, respectively), as well as S. aureus, methicillin-resistant S. aureus (MRSA), P. aeruginosa, and M. intracellulare bacteria (IC50s = 3, 7, 10, and 2.5 µg/ml, respectively).{52379} Hypocrellin A is also active against L. donovani promastigotes (IC50 = 0.27 µg/ml). Upon photoactivation with UV radiation, hypocrellin A induces production of reactive oxygen species and apoptosis and reduces cell viability of A549 cancer cells.{52380}
Brand:CaymanSKU:29933 - 10 mgAvailable on backorder
Hypocrellin A is a perylenequinoid that has been found in Shiraia bambusicola and has diverse biological activities.{52379,52380} It is active against C. albicans, C. parapsilosis, and C. tropicalis fungi (IC50s = 0.65, 1, and 85 µg/ml, respectively), as well as S. aureus, methicillin-resistant S. aureus (MRSA), P. aeruginosa, and M. intracellulare bacteria (IC50s = 3, 7, 10, and 2.5 µg/ml, respectively).{52379} Hypocrellin A is also active against L. donovani promastigotes (IC50 = 0.27 µg/ml). Upon photoactivation with UV radiation, hypocrellin A induces production of reactive oxygen species and apoptosis and reduces cell viability of A549 cancer cells.{52380}
Brand:CaymanSKU:29933 - 25 mgAvailable on backorder