Cayman
Showing 21901–22050 of 45550 results
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GHRP-6 is a synthetic growth hormone (GH) secretagogue and an agonist of the GH secretagogue receptor (GHS-R), which is also known as the ghrelin receptor.{49245,3021,49246,49247} It inhibits binding of the GHS-R agonist MK-0677 (ibutamoren; Item No. 18003) to COS-7 cell membranes expressing human GHS-R type Ia (Ki = 1.9 nM) and binding of ghrelin to COS-7 cells expressing human GHS-R (Kd = 260 nM).{3021,49246} GHRP-6 stimulates intracellular calcium mobilization in BHK cells expressing the human receptor (EC50 = 4.5 nM) and inositol phosphate production in COS-7 cells expressing the human receptor (EC50 = 0.83 nM).{49246} It also acts as a negative allosteric modulator of ghrelin (Item Nos. 15072 | 24458) signaling. GHRP-6 (0.03 μg/ml) induces release of GH, but not thyroid-stimulating hormone (TSH), luteinizing hormone (LH), or follicle-stimulating hormone (FSH), in isolated rat pituitary gland.{49245} It increases levels of GH, but not TSH, LH, FSH, or prolactin, in rat blood when administered subcutaneously at a dose of 50 μg. GHRP-6 increases food intake in rats when administered intracerebroventricularly at 0.3, 1, and 3 nmol.{49247}
Brand:CaymanSKU:27262 - 100 mgAvailable on backorder
GHRP-6 is a synthetic growth hormone (GH) secretagogue and an agonist of the GH secretagogue receptor (GHS-R), which is also known as the ghrelin receptor.{49245,3021,49246,49247} It inhibits binding of the GHS-R agonist MK-0677 (ibutamoren; Item No. 18003) to COS-7 cell membranes expressing human GHS-R type Ia (Ki = 1.9 nM) and binding of ghrelin to COS-7 cells expressing human GHS-R (Kd = 260 nM).{3021,49246} GHRP-6 stimulates intracellular calcium mobilization in BHK cells expressing the human receptor (EC50 = 4.5 nM) and inositol phosphate production in COS-7 cells expressing the human receptor (EC50 = 0.83 nM).{49246} It also acts as a negative allosteric modulator of ghrelin (Item Nos. 15072 | 24458) signaling. GHRP-6 (0.03 μg/ml) induces release of GH, but not thyroid-stimulating hormone (TSH), luteinizing hormone (LH), or follicle-stimulating hormone (FSH), in isolated rat pituitary gland.{49245} It increases levels of GH, but not TSH, LH, FSH, or prolactin, in rat blood when administered subcutaneously at a dose of 50 μg. GHRP-6 increases food intake in rats when administered intracerebroventricularly at 0.3, 1, and 3 nmol.{49247}
Brand:CaymanSKU:27262 - 5 mgAvailable on backorder
GHRP-6 is a synthetic growth hormone (GH) secretagogue and an agonist of the GH secretagogue receptor (GHS-R), which is also known as the ghrelin receptor.{49245,3021,49246,49247} It inhibits binding of the GHS-R agonist MK-0677 (ibutamoren; Item No. 18003) to COS-7 cell membranes expressing human GHS-R type Ia (Ki = 1.9 nM) and binding of ghrelin to COS-7 cells expressing human GHS-R (Kd = 260 nM).{3021,49246} GHRP-6 stimulates intracellular calcium mobilization in BHK cells expressing the human receptor (EC50 = 4.5 nM) and inositol phosphate production in COS-7 cells expressing the human receptor (EC50 = 0.83 nM).{49246} It also acts as a negative allosteric modulator of ghrelin (Item Nos. 15072 | 24458) signaling. GHRP-6 (0.03 μg/ml) induces release of GH, but not thyroid-stimulating hormone (TSH), luteinizing hormone (LH), or follicle-stimulating hormone (FSH), in isolated rat pituitary gland.{49245} It increases levels of GH, but not TSH, LH, FSH, or prolactin, in rat blood when administered subcutaneously at a dose of 50 μg. GHRP-6 increases food intake in rats when administered intracerebroventricularly at 0.3, 1, and 3 nmol.{49247}
Brand:CaymanSKU:27262 - 50 mgAvailable on backorder
GHV (sodium salt) (Item No. 28241) is an analytical reference standard categorized as a sedative.{42880} GHV is an active metabolite of γ-valerolactone (Item No. 28240).{34702} This product is intended for research and forensic applications.
Brand:CaymanSKU:28241 - 10 mgAvailable on backorder
GHV (sodium salt) (Item No. 28241) is an analytical reference standard categorized as a sedative.{42880} GHV is an active metabolite of γ-valerolactone (Item No. 28240).{34702} This product is intended for research and forensic applications.
Brand:CaymanSKU:28241 - 50 mgAvailable on backorder
GI 254023X is an inhibitor of the metalloproteinase-disintegrin ADAM10 (IC50 = 5.3 nM).{50359} It is selective for ADAM10 over ADAM17, matrix metalloproteinase-1 (MMP-1), and MMP-3 (IC50s = 541, 108, and 187 nM, respectively), but also inhibits MMP-9 and MMP-13 (IC50s = 2.5 and 1.1 nM, respectively). GI 254023X inhibits constitutive shedding of CX3CL1, but not shedding induced by phorbol 12-myristate 13-acetate (PMA; Item No. 10008014), in COS-7 cells transfected with human chemokines (IC50s = 0.4 and >10 μM, respectively). It also inhibits constitutive, but not PMA-induced, secretion of the IL-6 receptor (IL-6R) from THP-1 macrophages (IC50s = 1.8 and >10 μM, respectively). GX 254023X (1 μM) decreases shedding of low density lipoprotein receptor-related protein 1 (LRP1) induced by amyloid-β (1-42) (Aβ42; Item No. 20574) in human brain microvessel endothelial cells (HBMECs) and increases Aβ42 transit across an in vitro blood brain barrier model in a concentration-dependent manner.{50360} In vivo, GI 254023X (200 mg/kg) reduces brain LRP1 shedding and increases plasma levels of Aβ40 in a mouse model of Alzheimer’s disease.
Brand:CaymanSKU:28284 - 1 mgAvailable on backorder
GI 254023X is an inhibitor of the metalloproteinase-disintegrin ADAM10 (IC50 = 5.3 nM).{50359} It is selective for ADAM10 over ADAM17, matrix metalloproteinase-1 (MMP-1), and MMP-3 (IC50s = 541, 108, and 187 nM, respectively), but also inhibits MMP-9 and MMP-13 (IC50s = 2.5 and 1.1 nM, respectively). GI 254023X inhibits constitutive shedding of CX3CL1, but not shedding induced by phorbol 12-myristate 13-acetate (PMA; Item No. 10008014), in COS-7 cells transfected with human chemokines (IC50s = 0.4 and >10 μM, respectively). It also inhibits constitutive, but not PMA-induced, secretion of the IL-6 receptor (IL-6R) from THP-1 macrophages (IC50s = 1.8 and >10 μM, respectively). GX 254023X (1 μM) decreases shedding of low density lipoprotein receptor-related protein 1 (LRP1) induced by amyloid-β (1-42) (Aβ42; Item No. 20574) in human brain microvessel endothelial cells (HBMECs) and increases Aβ42 transit across an in vitro blood brain barrier model in a concentration-dependent manner.{50360} In vivo, GI 254023X (200 mg/kg) reduces brain LRP1 shedding and increases plasma levels of Aβ40 in a mouse model of Alzheimer’s disease.
Brand:CaymanSKU:28284 - 10 mgAvailable on backorder
GI 254023X is an inhibitor of the metalloproteinase-disintegrin ADAM10 (IC50 = 5.3 nM).{50359} It is selective for ADAM10 over ADAM17, matrix metalloproteinase-1 (MMP-1), and MMP-3 (IC50s = 541, 108, and 187 nM, respectively), but also inhibits MMP-9 and MMP-13 (IC50s = 2.5 and 1.1 nM, respectively). GI 254023X inhibits constitutive shedding of CX3CL1, but not shedding induced by phorbol 12-myristate 13-acetate (PMA; Item No. 10008014), in COS-7 cells transfected with human chemokines (IC50s = 0.4 and >10 μM, respectively). It also inhibits constitutive, but not PMA-induced, secretion of the IL-6 receptor (IL-6R) from THP-1 macrophages (IC50s = 1.8 and >10 μM, respectively). GX 254023X (1 μM) decreases shedding of low density lipoprotein receptor-related protein 1 (LRP1) induced by amyloid-β (1-42) (Aβ42; Item No. 20574) in human brain microvessel endothelial cells (HBMECs) and increases Aβ42 transit across an in vitro blood brain barrier model in a concentration-dependent manner.{50360} In vivo, GI 254023X (200 mg/kg) reduces brain LRP1 shedding and increases plasma levels of Aβ40 in a mouse model of Alzheimer’s disease.
Brand:CaymanSKU:28284 - 25 mgAvailable on backorder
GI 254023X is an inhibitor of the metalloproteinase-disintegrin ADAM10 (IC50 = 5.3 nM).{50359} It is selective for ADAM10 over ADAM17, matrix metalloproteinase-1 (MMP-1), and MMP-3 (IC50s = 541, 108, and 187 nM, respectively), but also inhibits MMP-9 and MMP-13 (IC50s = 2.5 and 1.1 nM, respectively). GI 254023X inhibits constitutive shedding of CX3CL1, but not shedding induced by phorbol 12-myristate 13-acetate (PMA; Item No. 10008014), in COS-7 cells transfected with human chemokines (IC50s = 0.4 and >10 μM, respectively). It also inhibits constitutive, but not PMA-induced, secretion of the IL-6 receptor (IL-6R) from THP-1 macrophages (IC50s = 1.8 and >10 μM, respectively). GX 254023X (1 μM) decreases shedding of low density lipoprotein receptor-related protein 1 (LRP1) induced by amyloid-β (1-42) (Aβ42; Item No. 20574) in human brain microvessel endothelial cells (HBMECs) and increases Aβ42 transit across an in vitro blood brain barrier model in a concentration-dependent manner.{50360} In vivo, GI 254023X (200 mg/kg) reduces brain LRP1 shedding and increases plasma levels of Aβ40 in a mouse model of Alzheimer’s disease.
Brand:CaymanSKU:28284 - 5 mgAvailable on backorder
Gibberellic acid is a diterpene fungal metabolite and plant hormone that has been found in Gibberella and various plants.{46607} It induces production of α-amylase to stimulate seed germination in cereal grains and stimulates photo- and skoto-morphogenesis and internode elongation in Arabidopsis. Gibberellic acid (150 μg per animal) increases testicular 3β-hydroxysteroid dehydrogenase (3β-HSD) and 17β-HSD activities and testosterone levels, markers of steroidogenesis, in rats.{46608} Dietary administration of gibberellic acid (300 ppm) to pregnant rats increases hepatic malondialdehyde (MDA) levels, decreases catalase, superoxide dismutase (SOD), and glutathione peroxidase (GPX) activities, and reduces hepatic function in both the pregnant rats and their offspring.{46609} Formulations containing gibberellic acid were previously used to enhance crop growth in agriculture.
Brand:CaymanSKU:29322 - 1 gAvailable on backorder
Gibberellic acid is a diterpene fungal metabolite and plant hormone that has been found in Gibberella and various plants.{46607} It induces production of α-amylase to stimulate seed germination in cereal grains and stimulates photo- and skoto-morphogenesis and internode elongation in Arabidopsis. Gibberellic acid (150 μg per animal) increases testicular 3β-hydroxysteroid dehydrogenase (3β-HSD) and 17β-HSD activities and testosterone levels, markers of steroidogenesis, in rats.{46608} Dietary administration of gibberellic acid (300 ppm) to pregnant rats increases hepatic malondialdehyde (MDA) levels, decreases catalase, superoxide dismutase (SOD), and glutathione peroxidase (GPX) activities, and reduces hepatic function in both the pregnant rats and their offspring.{46609} Formulations containing gibberellic acid were previously used to enhance crop growth in agriculture.
Brand:CaymanSKU:29322 - 10 gAvailable on backorder
Gibberellic acid is a diterpene fungal metabolite and plant hormone that has been found in Gibberella and various plants.{46607} It induces production of α-amylase to stimulate seed germination in cereal grains and stimulates photo- and skoto-morphogenesis and internode elongation in Arabidopsis. Gibberellic acid (150 μg per animal) increases testicular 3β-hydroxysteroid dehydrogenase (3β-HSD) and 17β-HSD activities and testosterone levels, markers of steroidogenesis, in rats.{46608} Dietary administration of gibberellic acid (300 ppm) to pregnant rats increases hepatic malondialdehyde (MDA) levels, decreases catalase, superoxide dismutase (SOD), and glutathione peroxidase (GPX) activities, and reduces hepatic function in both the pregnant rats and their offspring.{46609} Formulations containing gibberellic acid were previously used to enhance crop growth in agriculture.
Brand:CaymanSKU:29322 - 5 gAvailable on backorder
Gibberellic acid is a diterpene fungal metabolite and plant hormone that has been found in Gibberella and various plants.{46607} It induces production of α-amylase to stimulate seed germination in cereal grains and stimulates photo- and skoto-morphogenesis and internode elongation in Arabidopsis. Gibberellic acid (150 μg per animal) increases testicular 3β-hydroxysteroid dehydrogenase (3β-HSD) and 17β-HSD activities and testosterone levels, markers of steroidogenesis, in rats.{46608} Dietary administration of gibberellic acid (300 ppm) to pregnant rats increases hepatic malondialdehyde (MDA) levels, decreases catalase, superoxide dismutase (SOD), and glutathione peroxidase (GPX) activities, and reduces hepatic function in both the pregnant rats and their offspring.{46609} Formulations containing gibberellic acid were previously used to enhance crop growth in agriculture.
Brand:CaymanSKU:29322 - 50 gAvailable on backorder
Gibberellin A4 is a plant hormone originally isolated from G. fujikuroi that has plant signaling and growth stimulatory activities.{54423} Gibberellin A4 is found in the micropylar endothelium cells of Arabidopsis maternal seed tissue and triggers suspensor programmed cell death (PCD) in the embryo.{54424} It increases hypocotyl, but not radicle, growth of cucumber seedlings when used at concentrations ranging from 6-100 µM.{54425} Gibberellin A4 also increases flowering in apple trees when applied post-flowering in the previous year.{54426}
Brand:CaymanSKU:31400 - 1 mgAvailable on backorder
Gibberellin A4 is a plant hormone originally isolated from G. fujikuroi that has plant signaling and growth stimulatory activities.{54423} Gibberellin A4 is found in the micropylar endothelium cells of Arabidopsis maternal seed tissue and triggers suspensor programmed cell death (PCD) in the embryo.{54424} It increases hypocotyl, but not radicle, growth of cucumber seedlings when used at concentrations ranging from 6-100 µM.{54425} Gibberellin A4 also increases flowering in apple trees when applied post-flowering in the previous year.{54426}
Brand:CaymanSKU:31400 - 10 mgAvailable on backorder
Gibberellin A4 is a plant hormone originally isolated from G. fujikuroi that has plant signaling and growth stimulatory activities.{54423} Gibberellin A4 is found in the micropylar endothelium cells of Arabidopsis maternal seed tissue and triggers suspensor programmed cell death (PCD) in the embryo.{54424} It increases hypocotyl, but not radicle, growth of cucumber seedlings when used at concentrations ranging from 6-100 µM.{54425} Gibberellin A4 also increases flowering in apple trees when applied post-flowering in the previous year.{54426}
Brand:CaymanSKU:31400 - 25 mgAvailable on backorder
Gibberellin A4 is a plant hormone originally isolated from G. fujikuroi that has plant signaling and growth stimulatory activities.{54423} Gibberellin A4 is found in the micropylar endothelium cells of Arabidopsis maternal seed tissue and triggers suspensor programmed cell death (PCD) in the embryo.{54424} It increases hypocotyl, but not radicle, growth of cucumber seedlings when used at concentrations ranging from 6-100 µM.{54425} Gibberellin A4 also increases flowering in apple trees when applied post-flowering in the previous year.{54426}
Brand:CaymanSKU:31400 - 5 mgAvailable on backorder
Gilteritinib is a potent inhibitor at the FMS-related tyrosine kinase 3 (FLT3) and AXL tyrosine kinase receptors (IC50 = 0.29 nM and <1 nM, respectively).{33768} In preclinical studies, gilteritinib showed strong antileukemic and antitumor effects.{33769,33767} Gilteritinib is currently in several Phase 3 clinical trials for acute myeloid leukemia.
Brand:CaymanSKU:21503 -Out of stock
Gilteritinib is a potent inhibitor at the FMS-related tyrosine kinase 3 (FLT3) and AXL tyrosine kinase receptors (IC50 = 0.29 nM and <1 nM, respectively).{33768} In preclinical studies, gilteritinib showed strong antileukemic and antitumor effects.{33769,33767} Gilteritinib is currently in several Phase 3 clinical trials for acute myeloid leukemia.
Brand:CaymanSKU:21503 -Out of stock
Gilteritinib is a potent inhibitor at the FMS-related tyrosine kinase 3 (FLT3) and AXL tyrosine kinase receptors (IC50 = 0.29 nM and <1 nM, respectively).{33768} In preclinical studies, gilteritinib showed strong antileukemic and antitumor effects.{33769,33767} Gilteritinib is currently in several Phase 3 clinical trials for acute myeloid leukemia.
Brand:CaymanSKU:21503 -Out of stock
Gilteritinib is a potent inhibitor at the FMS-related tyrosine kinase 3 (FLT3) and AXL tyrosine kinase receptors (IC50 = 0.29 nM and <1 nM, respectively).{33768} In preclinical studies, gilteritinib showed strong antileukemic and antitumor effects.{33769,33767} Gilteritinib is currently in several Phase 3 clinical trials for acute myeloid leukemia.
Brand:CaymanSKU:21503 -Out of stock
Gilvocarcin M is an antibiotic originally isolated from S. gilvotanareus.{22205} It is active against S. aureus when used at a concentration of 32 µg/ml.{43405} Gilvocarcin M inhibits growth of KB cells (IC50 = 0.52 µg/ml) but has no effect on survival in a P388 mouse model of leukemia when used at doses ranging from 25 to 400 mg/kg.{22206} Gilvocarcin M intercalates into bacteriophage PM2 DNA.{43406} It is toxic to rats with an intravenous LD50 value of 450 mg/kg.{22206}
Brand:CaymanSKU:25762 - 2.5 mgAvailable on backorder
Gilvocarcin M is an antibiotic originally isolated from S. gilvotanareus.{22205} It is active against S. aureus when used at a concentration of 32 µg/ml.{43405} Gilvocarcin M inhibits growth of KB cells (IC50 = 0.52 µg/ml) but has no effect on survival in a P388 mouse model of leukemia when used at doses ranging from 25 to 400 mg/kg.{22206} Gilvocarcin M intercalates into bacteriophage PM2 DNA.{43406} It is toxic to rats with an intravenous LD50 value of 450 mg/kg.{22206}
Brand:CaymanSKU:25762 - 500 µgAvailable on backorder
Gilvocarcin V is an antitumor antibiotic with a coumarin-based aromatic structure that was originally isolated from the culture broth of S. gilvotanareus.{22202,22205} It is strongly active against Gram-positive bacteria such as S. aureus and B. subtilis and efficacious against experimental tumors including sarcoma 180, Ehrlich carcinoma, Meth I fibrosarcoma, MH134 hepatoma, and lymphocytic leukemia P388.{22206} Gilvocarcin V inhibits DNA synthesis by promoting the selective cross-linking of both histone H3 and the heat shock protein, GRP78 to DNA when photoactivated by near-UV or visible light.{22200}
Brand:CaymanSKU:- Gilvocarcin V is an antitumor antibiotic with a coumarin-based aromatic structure that was originally isolated from the culture broth of S. gilvotanareus.{22202,22205} It is strongly active against Gram-positive bacteria such as S. aureus and B. subtilis and efficacious against experimental tumors including sarcoma 180, Ehrlich carcinoma, Meth I fibrosarcoma, MH134 hepatoma, and lymphocytic leukemia P388.{22206} Gilvocarcin V inhibits DNA synthesis by promoting the selective cross-linking of both histone H3 and the heat shock protein, GRP78 to DNA when photoactivated by near-UV or visible light.{22200}
Brand:CaymanSKU:- Gilvocarcin V is an antitumor antibiotic with a coumarin-based aromatic structure that was originally isolated from the culture broth of S. gilvotanareus.{22202,22205} It is strongly active against Gram-positive bacteria such as S. aureus and B. subtilis and efficacious against experimental tumors including sarcoma 180, Ehrlich carcinoma, Meth I fibrosarcoma, MH134 hepatoma, and lymphocytic leukemia P388.{22206} Gilvocarcin V inhibits DNA synthesis by promoting the selective cross-linking of both histone H3 and the heat shock protein, GRP78 to DNA when photoactivated by near-UV or visible light.{22200}
Brand:CaymanSKU:- Gilvocarcin V is an antitumor antibiotic with a coumarin-based aromatic structure that was originally isolated from the culture broth of S. gilvotanareus.{22202,22205} It is strongly active against Gram-positive bacteria such as S. aureus and B. subtilis and efficacious against experimental tumors including sarcoma 180, Ehrlich carcinoma, Meth I fibrosarcoma, MH134 hepatoma, and lymphocytic leukemia P388.{22206} Gilvocarcin V inhibits DNA synthesis by promoting the selective cross-linking of both histone H3 and the heat shock protein, GRP78 to DNA when photoactivated by near-UV or visible light.{22200}
Brand:CaymanSKU:-
5-Fluorouracil (Item No. 14416) is a pyrimidine analog that irreversibly inhibits thymidylate synthase, blocking the synthesis of thymidine, which is required for DNA synthesis. It has been widely used to treat many gastrointestinal tract adenocarcinomas with mixed clinical efficacy.{22957} Gimeracil is an inhibitor of dihydropyrimidine dehydrogenase, the rate limiting enzyme for the catabolism of pyrimidines, including 5-fluorouracil. It has been administered concomitantly with 5-fluorouracil in a chemotherapy regimen termed S-1 to block 5-fluorouracil degradation, thus prolonging circulating 5-fluorouracil concentrations.{27082} Furthermore, at 1 mM gimeracil has been shown to inhibit homologous recombination in the repair of DNA double strand breaks, which can sensitize cancer cells to radiotherapy.{27083}
Brand:CaymanSKU:-Out of stock
5-Fluorouracil (Item No. 14416) is a pyrimidine analog that irreversibly inhibits thymidylate synthase, blocking the synthesis of thymidine, which is required for DNA synthesis. It has been widely used to treat many gastrointestinal tract adenocarcinomas with mixed clinical efficacy.{22957} Gimeracil is an inhibitor of dihydropyrimidine dehydrogenase, the rate limiting enzyme for the catabolism of pyrimidines, including 5-fluorouracil. It has been administered concomitantly with 5-fluorouracil in a chemotherapy regimen termed S-1 to block 5-fluorouracil degradation, thus prolonging circulating 5-fluorouracil concentrations.{27082} Furthermore, at 1 mM gimeracil has been shown to inhibit homologous recombination in the repair of DNA double strand breaks, which can sensitize cancer cells to radiotherapy.{27083}
Brand:CaymanSKU:-Out of stock
5-Fluorouracil (Item No. 14416) is a pyrimidine analog that irreversibly inhibits thymidylate synthase, blocking the synthesis of thymidine, which is required for DNA synthesis. It has been widely used to treat many gastrointestinal tract adenocarcinomas with mixed clinical efficacy.{22957} Gimeracil is an inhibitor of dihydropyrimidine dehydrogenase, the rate limiting enzyme for the catabolism of pyrimidines, including 5-fluorouracil. It has been administered concomitantly with 5-fluorouracil in a chemotherapy regimen termed S-1 to block 5-fluorouracil degradation, thus prolonging circulating 5-fluorouracil concentrations.{27082} Furthermore, at 1 mM gimeracil has been shown to inhibit homologous recombination in the repair of DNA double strand breaks, which can sensitize cancer cells to radiotherapy.{27083}
Brand:CaymanSKU:-Out of stock
5-Fluorouracil (Item No. 14416) is a pyrimidine analog that irreversibly inhibits thymidylate synthase, blocking the synthesis of thymidine, which is required for DNA synthesis. It has been widely used to treat many gastrointestinal tract adenocarcinomas with mixed clinical efficacy.{22957} Gimeracil is an inhibitor of dihydropyrimidine dehydrogenase, the rate limiting enzyme for the catabolism of pyrimidines, including 5-fluorouracil. It has been administered concomitantly with 5-fluorouracil in a chemotherapy regimen termed S-1 to block 5-fluorouracil degradation, thus prolonging circulating 5-fluorouracil concentrations.{27082} Furthermore, at 1 mM gimeracil has been shown to inhibit homologous recombination in the repair of DNA double strand breaks, which can sensitize cancer cells to radiotherapy.{27083}
Brand:CaymanSKU:-Out of stock
Ginkgetin is a biflavonoid that has been isolated from G. biloba and has diverse biological activities, including pro-apoptotic, antiproliferative, anti-inflammatory, anti-atherosclerosis, and neuroprotective properties.{36713,36714,36715,36716} It inhibits the proliferation of OVCAR-3 ovarian and HeLa cervical cancer cells (EC50s = 3 and 5.2 μg/ml, respectively) and induces apoptosis and caspase-3 cleavage in OVCAR-3 cells when used at a concentration of 3 μg/ml.{36713} Topical ginkgetin (20 μg/ear) reduces ear edema and prostaglandin E2 (PGE2; Item No. 14010) levels in a mouse model of chronic skin inflammation induced by phorbol 12-myristate 13-acetate (PMA; Item No. 10008014).{36714} It decreases the thickness of the intima-media and lipid plaque deposition in the thoracic aorta in a rat model of high-fat diet-induced atherosclerosis when administered at a dose of 100 mg/kg.{36715} Ginkgetin (0.8 mg/kg per day) improves sensorimotor coordination and increases the time spent on a rotating bar in a mouse model of Parkinson’s disease induced by MPTP.{36716}
Brand:CaymanSKU:25103 - 1 mgAvailable on backorder
Ginkgetin is a biflavonoid that has been isolated from G. biloba and has diverse biological activities, including pro-apoptotic, antiproliferative, anti-inflammatory, anti-atherosclerosis, and neuroprotective properties.{36713,36714,36715,36716} It inhibits the proliferation of OVCAR-3 ovarian and HeLa cervical cancer cells (EC50s = 3 and 5.2 μg/ml, respectively) and induces apoptosis and caspase-3 cleavage in OVCAR-3 cells when used at a concentration of 3 μg/ml.{36713} Topical ginkgetin (20 μg/ear) reduces ear edema and prostaglandin E2 (PGE2; Item No. 14010) levels in a mouse model of chronic skin inflammation induced by phorbol 12-myristate 13-acetate (PMA; Item No. 10008014).{36714} It decreases the thickness of the intima-media and lipid plaque deposition in the thoracic aorta in a rat model of high-fat diet-induced atherosclerosis when administered at a dose of 100 mg/kg.{36715} Ginkgetin (0.8 mg/kg per day) improves sensorimotor coordination and increases the time spent on a rotating bar in a mouse model of Parkinson’s disease induced by MPTP.{36716}
Brand:CaymanSKU:25103 - 10 mgAvailable on backorder
Ginkgetin is a biflavonoid that has been isolated from G. biloba and has diverse biological activities, including pro-apoptotic, antiproliferative, anti-inflammatory, anti-atherosclerosis, and neuroprotective properties.{36713,36714,36715,36716} It inhibits the proliferation of OVCAR-3 ovarian and HeLa cervical cancer cells (EC50s = 3 and 5.2 μg/ml, respectively) and induces apoptosis and caspase-3 cleavage in OVCAR-3 cells when used at a concentration of 3 μg/ml.{36713} Topical ginkgetin (20 μg/ear) reduces ear edema and prostaglandin E2 (PGE2; Item No. 14010) levels in a mouse model of chronic skin inflammation induced by phorbol 12-myristate 13-acetate (PMA; Item No. 10008014).{36714} It decreases the thickness of the intima-media and lipid plaque deposition in the thoracic aorta in a rat model of high-fat diet-induced atherosclerosis when administered at a dose of 100 mg/kg.{36715} Ginkgetin (0.8 mg/kg per day) improves sensorimotor coordination and increases the time spent on a rotating bar in a mouse model of Parkinson’s disease induced by MPTP.{36716}
Brand:CaymanSKU:25103 - 5 mgAvailable on backorder
Ginkgolide A is a terpenoid lactone originally isolated from G. biloba leaves with diverse biological activities.{22384} Ginkgolide A inhibits platelet activating factor-dependent aggregation of human platelets (IC50 = 15.8 μg/ml).{43127} It also inhibits GABA-induced currents in Xenopus oocytes expressing human α1β2γ2L GABAA receptors with an IC50 value of 12 μM.{43128} Ginkgolide A (100 μM) reduces the proliferation rate of OVCA429 ovarian cancer cells by 40%.{43129} In vivo, ginkgolide A (1-2 mg/kg, p.o.) increases the time spent in the open arms of the elevated plus maze by 3-fold without altering activity level in mice, indicating anxiolytic-like activity.{43131} Ginkgolide A (10 mg/kg, p.o.) also reduces hexobarbital-induced sleeping time in mice by 44%.{43130} Ginkolide A (30 mg/kg per day) increases activity of the cytochrome P450 (CYP450) isoforms CYP1A2 and CYP2E1 by 1.82- and 1.27-fold, respectively, in rats.{22384}
Brand:CaymanSKU:24970 - 10 mgAvailable on backorder
Ginkgolide A is a terpenoid lactone originally isolated from G. biloba leaves with diverse biological activities.{22384} Ginkgolide A inhibits platelet activating factor-dependent aggregation of human platelets (IC50 = 15.8 μg/ml).{43127} It also inhibits GABA-induced currents in Xenopus oocytes expressing human α1β2γ2L GABAA receptors with an IC50 value of 12 μM.{43128} Ginkgolide A (100 μM) reduces the proliferation rate of OVCA429 ovarian cancer cells by 40%.{43129} In vivo, ginkgolide A (1-2 mg/kg, p.o.) increases the time spent in the open arms of the elevated plus maze by 3-fold without altering activity level in mice, indicating anxiolytic-like activity.{43131} Ginkgolide A (10 mg/kg, p.o.) also reduces hexobarbital-induced sleeping time in mice by 44%.{43130} Ginkolide A (30 mg/kg per day) increases activity of the cytochrome P450 (CYP450) isoforms CYP1A2 and CYP2E1 by 1.82- and 1.27-fold, respectively, in rats.{22384}
Brand:CaymanSKU:24970 - 25 mgAvailable on backorder
Ginkgolide A is a terpenoid lactone originally isolated from G. biloba leaves with diverse biological activities.{22384} Ginkgolide A inhibits platelet activating factor-dependent aggregation of human platelets (IC50 = 15.8 μg/ml).{43127} It also inhibits GABA-induced currents in Xenopus oocytes expressing human α1β2γ2L GABAA receptors with an IC50 value of 12 μM.{43128} Ginkgolide A (100 μM) reduces the proliferation rate of OVCA429 ovarian cancer cells by 40%.{43129} In vivo, ginkgolide A (1-2 mg/kg, p.o.) increases the time spent in the open arms of the elevated plus maze by 3-fold without altering activity level in mice, indicating anxiolytic-like activity.{43131} Ginkgolide A (10 mg/kg, p.o.) also reduces hexobarbital-induced sleeping time in mice by 44%.{43130} Ginkolide A (30 mg/kg per day) increases activity of the cytochrome P450 (CYP450) isoforms CYP1A2 and CYP2E1 by 1.82- and 1.27-fold, respectively, in rats.{22384}
Brand:CaymanSKU:24970 - 5 mgAvailable on backorder
Ginkgolide A is a terpenoid lactone originally isolated from G. biloba leaves with diverse biological activities.{22384} Ginkgolide A inhibits platelet activating factor-dependent aggregation of human platelets (IC50 = 15.8 μg/ml).{43127} It also inhibits GABA-induced currents in Xenopus oocytes expressing human α1β2γ2L GABAA receptors with an IC50 value of 12 μM.{43128} Ginkgolide A (100 μM) reduces the proliferation rate of OVCA429 ovarian cancer cells by 40%.{43129} In vivo, ginkgolide A (1-2 mg/kg, p.o.) increases the time spent in the open arms of the elevated plus maze by 3-fold without altering activity level in mice, indicating anxiolytic-like activity.{43131} Ginkgolide A (10 mg/kg, p.o.) also reduces hexobarbital-induced sleeping time in mice by 44%.{43130} Ginkolide A (30 mg/kg per day) increases activity of the cytochrome P450 (CYP450) isoforms CYP1A2 and CYP2E1 by 1.82- and 1.27-fold, respectively, in rats.{22384}
Brand:CaymanSKU:24970 - 50 mgAvailable on backorder
Platelet-activating factor (PAF) is an important mediator of cell proliferation, angiogenesis, inflammatory response regulation, vasodilation, superoxide formation, and platelet aggregation.{939} These cellular effects are mediated through its specific G-protein coupled receptor, PAFR.{12279} Ginkgolide B, a terpenoid extracted from G. biloba leaves, is a potent PAFR antagonist that inhibits platelet aggregation at concentrations from 10-500 μM.{23210} It has been shown to inhibit non-mucinous ovarian cancer proliferation by blocking cell cycling.{16867} Ginkgolide B also demonstrates number of other anti-inflammatory, anti-allergic, antioxidant, and neuroprotective effects.{23211}
Brand:CaymanSKU:- Platelet-activating factor (PAF) is an important mediator of cell proliferation, angiogenesis, inflammatory response regulation, vasodilation, superoxide formation, and platelet aggregation.{939} These cellular effects are mediated through its specific G-protein coupled receptor, PAFR.{12279} Ginkgolide B, a terpenoid extracted from G. biloba leaves, is a potent PAFR antagonist that inhibits platelet aggregation at concentrations from 10-500 μM.{23210} It has been shown to inhibit non-mucinous ovarian cancer proliferation by blocking cell cycling.{16867} Ginkgolide B also demonstrates number of other anti-inflammatory, anti-allergic, antioxidant, and neuroprotective effects.{23211}
Brand:CaymanSKU:- Platelet-activating factor (PAF) is an important mediator of cell proliferation, angiogenesis, inflammatory response regulation, vasodilation, superoxide formation, and platelet aggregation.{939} These cellular effects are mediated through its specific G-protein coupled receptor, PAFR.{12279} Ginkgolide B, a terpenoid extracted from G. biloba leaves, is a potent PAFR antagonist that inhibits platelet aggregation at concentrations from 10-500 μM.{23210} It has been shown to inhibit non-mucinous ovarian cancer proliferation by blocking cell cycling.{16867} Ginkgolide B also demonstrates number of other anti-inflammatory, anti-allergic, antioxidant, and neuroprotective effects.{23211}
Brand:CaymanSKU:- Platelet-activating factor (PAF) is an important mediator of cell proliferation, angiogenesis, inflammatory response regulation, vasodilation, superoxide formation, and platelet aggregation.{939} These cellular effects are mediated through its specific G-protein coupled receptor, PAFR.{12279} Ginkgolide B, a terpenoid extracted from G. biloba leaves, is a potent PAFR antagonist that inhibits platelet aggregation at concentrations from 10-500 μM.{23210} It has been shown to inhibit non-mucinous ovarian cancer proliferation by blocking cell cycling.{16867} Ginkgolide B also demonstrates number of other anti-inflammatory, anti-allergic, antioxidant, and neuroprotective effects.{23211}
Brand:CaymanSKU:-
Ginkgolide C is a flavone first extracted from G. biloba leaves with multiple reported biological functions. It has been identified as a selective platelet activating factor receptor antagonist (IC50 = 37.6 μM).{6653} Ginkgolide C has also been shown to increase lipolysis and to inhibit adipogenesis in adipocytes via the activated AMPK pathway.{31746}
Brand:CaymanSKU:19872 -Available on backorder
Ginkgolide C is a flavone first extracted from G. biloba leaves with multiple reported biological functions. It has been identified as a selective platelet activating factor receptor antagonist (IC50 = 37.6 μM).{6653} Ginkgolide C has also been shown to increase lipolysis and to inhibit adipogenesis in adipocytes via the activated AMPK pathway.{31746}
Brand:CaymanSKU:19872 -Available on backorder
Ginkgolide C is a flavone first extracted from G. biloba leaves with multiple reported biological functions. It has been identified as a selective platelet activating factor receptor antagonist (IC50 = 37.6 μM).{6653} Ginkgolide C has also been shown to increase lipolysis and to inhibit adipogenesis in adipocytes via the activated AMPK pathway.{31746}
Brand:CaymanSKU:19872 -Available on backorder
Ginkgolide C is a flavone first extracted from G. biloba leaves with multiple reported biological functions. It has been identified as a selective platelet activating factor receptor antagonist (IC50 = 37.6 μM).{6653} Ginkgolide C has also been shown to increase lipolysis and to inhibit adipogenesis in adipocytes via the activated AMPK pathway.{31746}
Brand:CaymanSKU:19872 -Available on backorder
Ginkgolide J is a terpene trilactone originally isolated from G. biloba that has diverse biological activities. {6653,43127,47809} It inhibits platelet aggregation induced by platelet-activating factor (PAF) in rabbit and human platelet-rich plasma (IC50s = 27 and 43.5 μg/ml, respectively).{43127} Ginkgolide J (1 μM) inhibits cell death induced by amyloid-β (1-42) (Aβ42; Item No. 20574) in primary rat hippocampal neurons and reverses Aβ42-induced impairment of long-term potentiation (LTP) in the mouse CA1 region.{47809}
Brand:CaymanSKU:29163 - 1 mgAvailable on backorder
Ginkgolide J is a terpene trilactone originally isolated from G. biloba that has diverse biological activities. {6653,43127,47809} It inhibits platelet aggregation induced by platelet-activating factor (PAF) in rabbit and human platelet-rich plasma (IC50s = 27 and 43.5 μg/ml, respectively).{43127} Ginkgolide J (1 μM) inhibits cell death induced by amyloid-β (1-42) (Aβ42; Item No. 20574) in primary rat hippocampal neurons and reverses Aβ42-induced impairment of long-term potentiation (LTP) in the mouse CA1 region.{47809}
Brand:CaymanSKU:29163 - 10 mgAvailable on backorder
Ginkgolide J is a terpene trilactone originally isolated from G. biloba that has diverse biological activities. {6653,43127,47809} It inhibits platelet aggregation induced by platelet-activating factor (PAF) in rabbit and human platelet-rich plasma (IC50s = 27 and 43.5 μg/ml, respectively).{43127} Ginkgolide J (1 μM) inhibits cell death induced by amyloid-β (1-42) (Aβ42; Item No. 20574) in primary rat hippocampal neurons and reverses Aβ42-induced impairment of long-term potentiation (LTP) in the mouse CA1 region.{47809}
Brand:CaymanSKU:29163 - 25 mgAvailable on backorder
Ginkgolide J is a terpene trilactone originally isolated from G. biloba that has diverse biological activities. {6653,43127,47809} It inhibits platelet aggregation induced by platelet-activating factor (PAF) in rabbit and human platelet-rich plasma (IC50s = 27 and 43.5 μg/ml, respectively).{43127} Ginkgolide J (1 μM) inhibits cell death induced by amyloid-β (1-42) (Aβ42; Item No. 20574) in primary rat hippocampal neurons and reverses Aβ42-induced impairment of long-term potentiation (LTP) in the mouse CA1 region.{47809}
Brand:CaymanSKU:29163 - 5 mgAvailable on backorder
Ginkgoneolic acid is an anacardic acid and analog of anacardic acid monoene (Item No. 18422) originally isolated from G. biloba and has diverse biological activities.{48659,48660,48661,48662} It inhibits glycerol-3-phosphate dehydrogenase (GPDH; IC50 = 3 μg/ml).{48659} Ginkgoneolic acid inhibits PI3Kδ (IC50 = 2.49 μM) and IgE-mediated RBL-2H3 mast cell degranulation in vitro (IC50 = 2.4 μM).{48660} It reduces S. mutans biofilm formation with a 50% biofilm inhibition concentration (MBIC50) value of 4 μg/ml.{48661} Ginkgoneolic acid is molluscicidal against O. hupensis when used at a concentration of 2 mg/L.{48662}
Brand:CaymanSKU:27656 - 10 mgAvailable on backorder
Ginkgoneolic acid is an anacardic acid and analog of anacardic acid monoene (Item No. 18422) originally isolated from G. biloba and has diverse biological activities.{48659,48660,48661,48662} It inhibits glycerol-3-phosphate dehydrogenase (GPDH; IC50 = 3 μg/ml).{48659} Ginkgoneolic acid inhibits PI3Kδ (IC50 = 2.49 μM) and IgE-mediated RBL-2H3 mast cell degranulation in vitro (IC50 = 2.4 μM).{48660} It reduces S. mutans biofilm formation with a 50% biofilm inhibition concentration (MBIC50) value of 4 μg/ml.{48661} Ginkgoneolic acid is molluscicidal against O. hupensis when used at a concentration of 2 mg/L.{48662}
Brand:CaymanSKU:27656 - 100 mgAvailable on backorder
Ginkgoneolic acid is an anacardic acid and analog of anacardic acid monoene (Item No. 18422) originally isolated from G. biloba and has diverse biological activities.{48659,48660,48661,48662} It inhibits glycerol-3-phosphate dehydrogenase (GPDH; IC50 = 3 μg/ml).{48659} Ginkgoneolic acid inhibits PI3Kδ (IC50 = 2.49 μM) and IgE-mediated RBL-2H3 mast cell degranulation in vitro (IC50 = 2.4 μM).{48660} It reduces S. mutans biofilm formation with a 50% biofilm inhibition concentration (MBIC50) value of 4 μg/ml.{48661} Ginkgoneolic acid is molluscicidal against O. hupensis when used at a concentration of 2 mg/L.{48662}
Brand:CaymanSKU:27656 - 25 mgAvailable on backorder
Ginkgoneolic acid is an anacardic acid and analog of anacardic acid monoene (Item No. 18422) originally isolated from G. biloba and has diverse biological activities.{48659,48660,48661,48662} It inhibits glycerol-3-phosphate dehydrogenase (GPDH; IC50 = 3 μg/ml).{48659} Ginkgoneolic acid inhibits PI3Kδ (IC50 = 2.49 μM) and IgE-mediated RBL-2H3 mast cell degranulation in vitro (IC50 = 2.4 μM).{48660} It reduces S. mutans biofilm formation with a 50% biofilm inhibition concentration (MBIC50) value of 4 μg/ml.{48661} Ginkgoneolic acid is molluscicidal against O. hupensis when used at a concentration of 2 mg/L.{48662}
Brand:CaymanSKU:27656 - 50 mgAvailable on backorder
Ginsenoside CK is a metabolite of the saponin ginsenoside Rb1 (Item No. 15319) that has diverse biological activities.{52367,52368,52369,52370} Ginsenoside CK is formed from ginsenoside Rb1 via intestinal bacterial exo-β-D-glucosidase.{52367} It reduces protein levels of matrix metalloproteinase-2 (MMP-2) and pro-MMP-9 in, and inhibits growth, adhesion, and invasion of, MHCC97-H human hepatocellular carcinoma cells (HCCs) when used at concentrations of 50 and 75 µM.{52368} It inhibits metastasis in an MHCC97-H mouse xenograft model but does not reduce tumor growth. Ginsenoside CK reduces the percentage of memory B cells in the spleen, the number of swollen joints, and lymph node hyperplasia in an adjuvant-induced model of rheumatoid arthritis.{52369} It increases the activity of pSer9-glycogen synthase kinase and insulin degrading enzyme (IDE) and reduces the accumulation of amyloid-β (1-42) (Aβ42; Item No. 20574) in the rat hippocampal CA1 and CA3 regions in a model of vascular dementia induced by chronic cerebral hypofusion.{52370} It also increases the percentage of time spent in the target quadrant of the Morris water maze when administered at doses of 100 and 200 mg/kg in the same model.
Brand:CaymanSKU:29926 - 10 mgAvailable on backorder
Ginsenoside CK is a metabolite of the saponin ginsenoside Rb1 (Item No. 15319) that has diverse biological activities.{52367,52368,52369,52370} Ginsenoside CK is formed from ginsenoside Rb1 via intestinal bacterial exo-β-D-glucosidase.{52367} It reduces protein levels of matrix metalloproteinase-2 (MMP-2) and pro-MMP-9 in, and inhibits growth, adhesion, and invasion of, MHCC97-H human hepatocellular carcinoma cells (HCCs) when used at concentrations of 50 and 75 µM.{52368} It inhibits metastasis in an MHCC97-H mouse xenograft model but does not reduce tumor growth. Ginsenoside CK reduces the percentage of memory B cells in the spleen, the number of swollen joints, and lymph node hyperplasia in an adjuvant-induced model of rheumatoid arthritis.{52369} It increases the activity of pSer9-glycogen synthase kinase and insulin degrading enzyme (IDE) and reduces the accumulation of amyloid-β (1-42) (Aβ42; Item No. 20574) in the rat hippocampal CA1 and CA3 regions in a model of vascular dementia induced by chronic cerebral hypofusion.{52370} It also increases the percentage of time spent in the target quadrant of the Morris water maze when administered at doses of 100 and 200 mg/kg in the same model.
Brand:CaymanSKU:29926 - 25 mgAvailable on backorder
Ginsenoside CK is a metabolite of the saponin ginsenoside Rb1 (Item No. 15319) that has diverse biological activities.{52367,52368,52369,52370} Ginsenoside CK is formed from ginsenoside Rb1 via intestinal bacterial exo-β-D-glucosidase.{52367} It reduces protein levels of matrix metalloproteinase-2 (MMP-2) and pro-MMP-9 in, and inhibits growth, adhesion, and invasion of, MHCC97-H human hepatocellular carcinoma cells (HCCs) when used at concentrations of 50 and 75 µM.{52368} It inhibits metastasis in an MHCC97-H mouse xenograft model but does not reduce tumor growth. Ginsenoside CK reduces the percentage of memory B cells in the spleen, the number of swollen joints, and lymph node hyperplasia in an adjuvant-induced model of rheumatoid arthritis.{52369} It increases the activity of pSer9-glycogen synthase kinase and insulin degrading enzyme (IDE) and reduces the accumulation of amyloid-β (1-42) (Aβ42; Item No. 20574) in the rat hippocampal CA1 and CA3 regions in a model of vascular dementia induced by chronic cerebral hypofusion.{52370} It also increases the percentage of time spent in the target quadrant of the Morris water maze when administered at doses of 100 and 200 mg/kg in the same model.
Brand:CaymanSKU:29926 - 5 mgAvailable on backorder
Ginsenoside F1 (GF1) is a ginsenoside that has been found in P. ginseng and has diverse biological activities.{59505,59506,59508,59507} It increases cytotoxic degranulation of natural killer (NK) cells against K562 leukemia cells in vitro when used at a concentration of 10 µM and enhances NK cell-mediated lymphoma clearance in vivo.{59505} GF1 (50 mg/kg) reduces atherosclerotic lesion area, whole body myeloperoxidase (MPO) levels, and aortic root NF-kB, TLR4, and LOX-1 levels in ApoE-/- mice.{59506} It increases microvessel density and improves focal cerebral blood perfusion in a rat model of ischemic stroke induced by middle cerebral artery occlusion (MCAO).{59508} GF1 also restores spatial working memory, but not context-dependent fear memory, in the APP/PS1 transgenic mouse model of Alzheimer’s disease.{59507}
Brand:CaymanSKU:31137 - 1 mgAvailable on backorder
Ginsenoside F1 (GF1) is a ginsenoside that has been found in P. ginseng and has diverse biological activities.{59505,59506,59508,59507} It increases cytotoxic degranulation of natural killer (NK) cells against K562 leukemia cells in vitro when used at a concentration of 10 µM and enhances NK cell-mediated lymphoma clearance in vivo.{59505} GF1 (50 mg/kg) reduces atherosclerotic lesion area, whole body myeloperoxidase (MPO) levels, and aortic root NF-kB, TLR4, and LOX-1 levels in ApoE-/- mice.{59506} It increases microvessel density and improves focal cerebral blood perfusion in a rat model of ischemic stroke induced by middle cerebral artery occlusion (MCAO).{59508} GF1 also restores spatial working memory, but not context-dependent fear memory, in the APP/PS1 transgenic mouse model of Alzheimer’s disease.{59507}
Brand:CaymanSKU:31137 - 10 mgAvailable on backorder
Ginsenoside F1 (GF1) is a ginsenoside that has been found in P. ginseng and has diverse biological activities.{59505,59506,59508,59507} It increases cytotoxic degranulation of natural killer (NK) cells against K562 leukemia cells in vitro when used at a concentration of 10 µM and enhances NK cell-mediated lymphoma clearance in vivo.{59505} GF1 (50 mg/kg) reduces atherosclerotic lesion area, whole body myeloperoxidase (MPO) levels, and aortic root NF-kB, TLR4, and LOX-1 levels in ApoE-/- mice.{59506} It increases microvessel density and improves focal cerebral blood perfusion in a rat model of ischemic stroke induced by middle cerebral artery occlusion (MCAO).{59508} GF1 also restores spatial working memory, but not context-dependent fear memory, in the APP/PS1 transgenic mouse model of Alzheimer’s disease.{59507}
Brand:CaymanSKU:31137 - 25 mgAvailable on backorder
Ginsenoside F1 (GF1) is a ginsenoside that has been found in P. ginseng and has diverse biological activities.{59505,59506,59508,59507} It increases cytotoxic degranulation of natural killer (NK) cells against K562 leukemia cells in vitro when used at a concentration of 10 µM and enhances NK cell-mediated lymphoma clearance in vivo.{59505} GF1 (50 mg/kg) reduces atherosclerotic lesion area, whole body myeloperoxidase (MPO) levels, and aortic root NF-kB, TLR4, and LOX-1 levels in ApoE-/- mice.{59506} It increases microvessel density and improves focal cerebral blood perfusion in a rat model of ischemic stroke induced by middle cerebral artery occlusion (MCAO).{59508} GF1 also restores spatial working memory, but not context-dependent fear memory, in the APP/PS1 transgenic mouse model of Alzheimer’s disease.{59507}
Brand:CaymanSKU:31137 - 5 mgAvailable on backorder
Ginsenoside F2 is a ginsenoside that has been found in P. ginseng and has diverse biological activities.{52461,52462,52463} It increases the proliferation of human hair dermal papilla cells (HHDPCs) and HaCaT human keratinocytes when used at concentrations of 0.01, 0.1, and 1 μM.{52461} Ginsenoside F2 (0.5 and 2.5 mg/kg) induces hair growth and increases hair density following depilation in mice. It is cytotoxic to U373MG glioblastoma cells in vitro (IC50 = 50 μg/ml) and reduces tumor growth in a U373MG mouse xenograft model when administered at a dose of 35 mg/kg every other day.{52462} Ginsenoside F2 (1 mg/ear) reduces ear edema induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in mice.{52463} It is a human intestinal bacterial metabolite of ginsenoside Rb1 (Item No. 15319) via the intermediate ginsenoside Rd (Item No. 15329).{52464}
Brand:CaymanSKU:23435 - 1 mgAvailable on backorder
Ginsenoside F2 is a ginsenoside that has been found in P. ginseng and has diverse biological activities.{52461,52462,52463} It increases the proliferation of human hair dermal papilla cells (HHDPCs) and HaCaT human keratinocytes when used at concentrations of 0.01, 0.1, and 1 μM.{52461} Ginsenoside F2 (0.5 and 2.5 mg/kg) induces hair growth and increases hair density following depilation in mice. It is cytotoxic to U373MG glioblastoma cells in vitro (IC50 = 50 μg/ml) and reduces tumor growth in a U373MG mouse xenograft model when administered at a dose of 35 mg/kg every other day.{52462} Ginsenoside F2 (1 mg/ear) reduces ear edema induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in mice.{52463} It is a human intestinal bacterial metabolite of ginsenoside Rb1 (Item No. 15319) via the intermediate ginsenoside Rd (Item No. 15329).{52464}
Brand:CaymanSKU:23435 - 10 mgAvailable on backorder
Ginsenoside F2 is a ginsenoside that has been found in P. ginseng and has diverse biological activities.{52461,52462,52463} It increases the proliferation of human hair dermal papilla cells (HHDPCs) and HaCaT human keratinocytes when used at concentrations of 0.01, 0.1, and 1 μM.{52461} Ginsenoside F2 (0.5 and 2.5 mg/kg) induces hair growth and increases hair density following depilation in mice. It is cytotoxic to U373MG glioblastoma cells in vitro (IC50 = 50 μg/ml) and reduces tumor growth in a U373MG mouse xenograft model when administered at a dose of 35 mg/kg every other day.{52462} Ginsenoside F2 (1 mg/ear) reduces ear edema induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in mice.{52463} It is a human intestinal bacterial metabolite of ginsenoside Rb1 (Item No. 15319) via the intermediate ginsenoside Rd (Item No. 15329).{52464}
Brand:CaymanSKU:23435 - 25 mgAvailable on backorder
Ginsenoside F2 is a ginsenoside that has been found in P. ginseng and has diverse biological activities.{52461,52462,52463} It increases the proliferation of human hair dermal papilla cells (HHDPCs) and HaCaT human keratinocytes when used at concentrations of 0.01, 0.1, and 1 μM.{52461} Ginsenoside F2 (0.5 and 2.5 mg/kg) induces hair growth and increases hair density following depilation in mice. It is cytotoxic to U373MG glioblastoma cells in vitro (IC50 = 50 μg/ml) and reduces tumor growth in a U373MG mouse xenograft model when administered at a dose of 35 mg/kg every other day.{52462} Ginsenoside F2 (1 mg/ear) reduces ear edema induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in mice.{52463} It is a human intestinal bacterial metabolite of ginsenoside Rb1 (Item No. 15319) via the intermediate ginsenoside Rd (Item No. 15329).{52464}
Brand:CaymanSKU:23435 - 5 mgAvailable on backorder
Ginsenoside F3 is a ginsenoside that has been found in P. ginseng and has immunomodulatory activity.{57253} It increases proliferation of isolated mouse spleen cells and the production of IL-2 and IFN-γ, as well as decreases the production of IL-4 and IL-10, when used at concentrations ranging from 0.1 to 100 µM. Ginsenoside F3 (10 µM) also increases the DNA binding activity of NF-κB induced by concanavalin A (Item No. 14951) in isolated mouse spleen cells.
Brand:CaymanSKU:31409 - 1 mgAvailable on backorder
Ginsenoside F3 is a ginsenoside that has been found in P. ginseng and has immunomodulatory activity.{57253} It increases proliferation of isolated mouse spleen cells and the production of IL-2 and IFN-γ, as well as decreases the production of IL-4 and IL-10, when used at concentrations ranging from 0.1 to 100 µM. Ginsenoside F3 (10 µM) also increases the DNA binding activity of NF-κB induced by concanavalin A (Item No. 14951) in isolated mouse spleen cells.
Brand:CaymanSKU:31409 - 10 mgAvailable on backorder
Ginsenoside F3 is a ginsenoside that has been found in P. ginseng and has immunomodulatory activity.{57253} It increases proliferation of isolated mouse spleen cells and the production of IL-2 and IFN-γ, as well as decreases the production of IL-4 and IL-10, when used at concentrations ranging from 0.1 to 100 µM. Ginsenoside F3 (10 µM) also increases the DNA binding activity of NF-κB induced by concanavalin A (Item No. 14951) in isolated mouse spleen cells.
Brand:CaymanSKU:31409 - 5 mgAvailable on backorder
Ginsenosides are pharmacologically active natural compounds from ginseng and other plants of the genus Panax.{24877} Structurally, they are steroid glycosides derived from the triterpene squalene.{24877} They are named according to their migration on thin layer chromatography plates, from the bottom to the top.{24877} Ginsenoside Rb1 is a protopanaxadiol, which is more abundant in some Panax species (e.g., P. quinquefolium) than others.{24880} This ginsenoside and its metabolites have diverse in vitro and in vivo effects, including neuroprotective, anti-inflammatory, and anti-obesity actions.{24880,24876,24875} Ginsenoside Rb1 may inhibit apoptosis, while its metabolites can promote this response.{24876,24878} Notably, this ginsenoside is converted to other forms in response to steaming or heating plant materials, leading to loss of activity.{24880,24879}
Brand:CaymanSKU:- Ginsenosides are pharmacologically active natural compounds from ginseng and other plants of the genus Panax.{24877} Structurally, they are steroid glycosides derived from the triterpene squalene.{24877} They are named according to their migration on thin layer chromatography plates, from the bottom to the top.{24877} Ginsenoside Rb1 is a protopanaxadiol, which is more abundant in some Panax species (e.g., P. quinquefolium) than others.{24880} This ginsenoside and its metabolites have diverse in vitro and in vivo effects, including neuroprotective, anti-inflammatory, and anti-obesity actions.{24880,24876,24875} Ginsenoside Rb1 may inhibit apoptosis, while its metabolites can promote this response.{24876,24878} Notably, this ginsenoside is converted to other forms in response to steaming or heating plant materials, leading to loss of activity.{24880,24879}
Brand:CaymanSKU:- Ginsenosides are pharmacologically active natural compounds from ginseng and other plants of the genus Panax.{24877} Structurally, they are steroid glycosides derived from the triterpene squalene.{24877} They are named according to their migration on thin layer chromatography plates, from the bottom to the top.{24877} Ginsenoside Rb1 is a protopanaxadiol, which is more abundant in some Panax species (e.g., P. quinquefolium) than others.{24880} This ginsenoside and its metabolites have diverse in vitro and in vivo effects, including neuroprotective, anti-inflammatory, and anti-obesity actions.{24880,24876,24875} Ginsenoside Rb1 may inhibit apoptosis, while its metabolites can promote this response.{24876,24878} Notably, this ginsenoside is converted to other forms in response to steaming or heating plant materials, leading to loss of activity.{24880,24879}
Brand:CaymanSKU:-
Ginsenoside Rb2 is a steroid glycoside found in plants of the genus Panax that has diverse biological activities.{24877} It inhibits LPS-stimulated increases in vascular cell adhesion molecule 1 (VCAM-1) and intercellular adhesion molecule 1 (ICAM-1) expression in vitro. It dose-dependently reverses LPS-induced decreases in the expression of IκBα in human umbilical vein endothelial cells (HUVECs).{25807} Ginsenoside Rb2 reduces adhesion of THP-1 cells to LPS-stimulated HUVEC cells, also in a dose-dependent manner. Ginsenoside Rb2 reduces UVB-induced cytotoxicity and apoptotic nuclear fragmentation in HaCaT cells.{25810} It also lowers total cholesterol and triacylglycerol in 3T3-L1 adipocytes cultured under high fatty acid conditions to levels comparable to lovastatin (Item No. 10010338).{39216}
Brand:CaymanSKU:22265 -Out of stock
Ginsenoside Rb2 is a steroid glycoside found in plants of the genus Panax that has diverse biological activities.{24877} It inhibits LPS-stimulated increases in vascular cell adhesion molecule 1 (VCAM-1) and intercellular adhesion molecule 1 (ICAM-1) expression in vitro. It dose-dependently reverses LPS-induced decreases in the expression of IκBα in human umbilical vein endothelial cells (HUVECs).{25807} Ginsenoside Rb2 reduces adhesion of THP-1 cells to LPS-stimulated HUVEC cells, also in a dose-dependent manner. Ginsenoside Rb2 reduces UVB-induced cytotoxicity and apoptotic nuclear fragmentation in HaCaT cells.{25810} It also lowers total cholesterol and triacylglycerol in 3T3-L1 adipocytes cultured under high fatty acid conditions to levels comparable to lovastatin (Item No. 10010338).{39216}
Brand:CaymanSKU:22265 -Out of stock
Ginsenoside Rb2 is a steroid glycoside found in plants of the genus Panax that has diverse biological activities.{24877} It inhibits LPS-stimulated increases in vascular cell adhesion molecule 1 (VCAM-1) and intercellular adhesion molecule 1 (ICAM-1) expression in vitro. It dose-dependently reverses LPS-induced decreases in the expression of IκBα in human umbilical vein endothelial cells (HUVECs).{25807} Ginsenoside Rb2 reduces adhesion of THP-1 cells to LPS-stimulated HUVEC cells, also in a dose-dependent manner. Ginsenoside Rb2 reduces UVB-induced cytotoxicity and apoptotic nuclear fragmentation in HaCaT cells.{25810} It also lowers total cholesterol and triacylglycerol in 3T3-L1 adipocytes cultured under high fatty acid conditions to levels comparable to lovastatin (Item No. 10010338).{39216}
Brand:CaymanSKU:22265 -Out of stock
Ginsenoside Rb3 is a steroid glycoside that has been found in Panax and has diverse biological activities.{46577,46578,46579,46580,46581} It inhibits JNK-mediated activation of NF-κB and apoptosis induced by oxygen-glucose deprivation (OGD) in H9c2 mouse cardiac myoblasts in vitro and reduces myocardial apoptosis and production of reactive oxygen species (ROS) in a rat model of myocardial ischemia-reperfusion injury when administered at a dose of 20 mg/kg.{46577,46578} Ginsenoside Rb3 (10 and 20 mg/kg per day for 10 days) prevents increases in serum creatinine, blood urea nitrogen (BUN), and malondialdehyde (MDA) levels, and decreases in superoxide dismutase (SOD) activity and glutathione (GSH) levels, as well as inhibits renal cell apoptosis in a mouse model of nephrotoxicity induced by cisplatin (Item No. 13119).{46579} It decreases the abundance of cancer cachexia-associated gut microbiota and the number of polyps in the ApcMin/+ mouse model of colon cancer.{46580} Ginsenoside Rb3 also decreases immobility time in the forced swim and tail suspension tests, indicating antidepressant-like activity, in mice.{46581}
Brand:CaymanSKU:29005 - 10 mgAvailable on backorder
Ginsenoside Rb3 is a steroid glycoside that has been found in Panax and has diverse biological activities.{46577,46578,46579,46580,46581} It inhibits JNK-mediated activation of NF-κB and apoptosis induced by oxygen-glucose deprivation (OGD) in H9c2 mouse cardiac myoblasts in vitro and reduces myocardial apoptosis and production of reactive oxygen species (ROS) in a rat model of myocardial ischemia-reperfusion injury when administered at a dose of 20 mg/kg.{46577,46578} Ginsenoside Rb3 (10 and 20 mg/kg per day for 10 days) prevents increases in serum creatinine, blood urea nitrogen (BUN), and malondialdehyde (MDA) levels, and decreases in superoxide dismutase (SOD) activity and glutathione (GSH) levels, as well as inhibits renal cell apoptosis in a mouse model of nephrotoxicity induced by cisplatin (Item No. 13119).{46579} It decreases the abundance of cancer cachexia-associated gut microbiota and the number of polyps in the ApcMin/+ mouse model of colon cancer.{46580} Ginsenoside Rb3 also decreases immobility time in the forced swim and tail suspension tests, indicating antidepressant-like activity, in mice.{46581}
Brand:CaymanSKU:29005 - 100 mgAvailable on backorder
Ginsenoside Rb3 is a steroid glycoside that has been found in Panax and has diverse biological activities.{46577,46578,46579,46580,46581} It inhibits JNK-mediated activation of NF-κB and apoptosis induced by oxygen-glucose deprivation (OGD) in H9c2 mouse cardiac myoblasts in vitro and reduces myocardial apoptosis and production of reactive oxygen species (ROS) in a rat model of myocardial ischemia-reperfusion injury when administered at a dose of 20 mg/kg.{46577,46578} Ginsenoside Rb3 (10 and 20 mg/kg per day for 10 days) prevents increases in serum creatinine, blood urea nitrogen (BUN), and malondialdehyde (MDA) levels, and decreases in superoxide dismutase (SOD) activity and glutathione (GSH) levels, as well as inhibits renal cell apoptosis in a mouse model of nephrotoxicity induced by cisplatin (Item No. 13119).{46579} It decreases the abundance of cancer cachexia-associated gut microbiota and the number of polyps in the ApcMin/+ mouse model of colon cancer.{46580} Ginsenoside Rb3 also decreases immobility time in the forced swim and tail suspension tests, indicating antidepressant-like activity, in mice.{46581}
Brand:CaymanSKU:29005 - 5 mgAvailable on backorder
Ginsenoside Rb3 is a steroid glycoside that has been found in Panax and has diverse biological activities.{46577,46578,46579,46580,46581} It inhibits JNK-mediated activation of NF-κB and apoptosis induced by oxygen-glucose deprivation (OGD) in H9c2 mouse cardiac myoblasts in vitro and reduces myocardial apoptosis and production of reactive oxygen species (ROS) in a rat model of myocardial ischemia-reperfusion injury when administered at a dose of 20 mg/kg.{46577,46578} Ginsenoside Rb3 (10 and 20 mg/kg per day for 10 days) prevents increases in serum creatinine, blood urea nitrogen (BUN), and malondialdehyde (MDA) levels, and decreases in superoxide dismutase (SOD) activity and glutathione (GSH) levels, as well as inhibits renal cell apoptosis in a mouse model of nephrotoxicity induced by cisplatin (Item No. 13119).{46579} It decreases the abundance of cancer cachexia-associated gut microbiota and the number of polyps in the ApcMin/+ mouse model of colon cancer.{46580} Ginsenoside Rb3 also decreases immobility time in the forced swim and tail suspension tests, indicating antidepressant-like activity, in mice.{46581}
Brand:CaymanSKU:29005 - 50 mgAvailable on backorder
Ginsenoside Rc is a saponin that has been found in P. ginseng and has diverse biological activities, including antioxidant, anti-inflammatory, and nootropic properties.{45626,45627,45628} It prevents UVB-induced increases in the levels of reactive oxygen species (ROS) in HaCaT keratinocytes by 34.3, 54.4, and 65.4% when used at concentrations of 5, 12, and 30 µM, respectively.{45626} Ginsenoside Rc (40 µg/ml) reduces increases in the expression of Tnf, Il1b, and Ifnb1 induced by LPS in RAW 264.7 cells.{45627} It reduces gastric ulcer and joint lesion indices in mouse models of HCl/ethanol-induced gastritis and collagen-induced arthritis, respectively, as well as reduces increased serum levels of aspartate aminotransferase (AST) induced by LPS/D-galactosamine in a mouse model of hepatitis, when administered at a dose of 20 mg/kg. Ginsenoside Rc increases GABA-induced inward current in Xenopus oocytes expressing recombinant human α1β1ɣ2S subunit-containing GABAA receptors with an EC50 value of 53.2 µM.{45628}
Brand:CaymanSKU:29088 - 10 mgAvailable on backorder
Ginsenoside Rc is a saponin that has been found in P. ginseng and has diverse biological activities, including antioxidant, anti-inflammatory, and nootropic properties.{45626,45627,45628} It prevents UVB-induced increases in the levels of reactive oxygen species (ROS) in HaCaT keratinocytes by 34.3, 54.4, and 65.4% when used at concentrations of 5, 12, and 30 µM, respectively.{45626} Ginsenoside Rc (40 µg/ml) reduces increases in the expression of Tnf, Il1b, and Ifnb1 induced by LPS in RAW 264.7 cells.{45627} It reduces gastric ulcer and joint lesion indices in mouse models of HCl/ethanol-induced gastritis and collagen-induced arthritis, respectively, as well as reduces increased serum levels of aspartate aminotransferase (AST) induced by LPS/D-galactosamine in a mouse model of hepatitis, when administered at a dose of 20 mg/kg. Ginsenoside Rc increases GABA-induced inward current in Xenopus oocytes expressing recombinant human α1β1ɣ2S subunit-containing GABAA receptors with an EC50 value of 53.2 µM.{45628}
Brand:CaymanSKU:29088 - 25 mgAvailable on backorder
Ginsenoside Rc is a saponin that has been found in P. ginseng and has diverse biological activities, including antioxidant, anti-inflammatory, and nootropic properties.{45626,45627,45628} It prevents UVB-induced increases in the levels of reactive oxygen species (ROS) in HaCaT keratinocytes by 34.3, 54.4, and 65.4% when used at concentrations of 5, 12, and 30 µM, respectively.{45626} Ginsenoside Rc (40 µg/ml) reduces increases in the expression of Tnf, Il1b, and Ifnb1 induced by LPS in RAW 264.7 cells.{45627} It reduces gastric ulcer and joint lesion indices in mouse models of HCl/ethanol-induced gastritis and collagen-induced arthritis, respectively, as well as reduces increased serum levels of aspartate aminotransferase (AST) induced by LPS/D-galactosamine in a mouse model of hepatitis, when administered at a dose of 20 mg/kg. Ginsenoside Rc increases GABA-induced inward current in Xenopus oocytes expressing recombinant human α1β1ɣ2S subunit-containing GABAA receptors with an EC50 value of 53.2 µM.{45628}
Brand:CaymanSKU:29088 - 5 mgAvailable on backorder