Cayman
Showing 21751–21900 of 45550 results
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GDC-0980 is a potent inhibitor of class I phosphatidylinositol 3-kinase (PI3K) isoforms, with IC50 values of 5, 27, 7, and 14 nM for PI3Kα, β, δ, and γ, respectively, in cell-free assays.{29877,29878} It also inhibits mTOR (Ki = 17 nM) but is inactive against a large panel of additional kinases.{29877,29878} GDC-0980 induces cell cycle arrest or apoptosis in a range of cancer cell lines.{29878} It is effective in vivo, suppressing the growth of a number of tumor xenografts in mice and enhancing the antitumor activity of docetaxel (Item No. 11637) in mice.{29878}
Brand:CaymanSKU:-Available on backorder
GDC-0994 is a potent and selective ERK1 and ERK2 inhibitor with IC50 values of 6.1 and 4.1 nM, respectively.{33248} It inhibits ERK-dependent p90RSK serine 380 phosphorylation in PMA-stimulated HepG2 cells with an IC50 value of 12 nM. GDC-0994 inhibited growth of HCT116 human colorectal cancer xenograft tumors by 49%, 57%, and 80% at 30, 60, and 100 mg/kg, respectively, when administered orally once daily for 21 days.{33248}
Brand:CaymanSKU:21107 -Out of stock
GDC-0994 is a potent and selective ERK1 and ERK2 inhibitor with IC50 values of 6.1 and 4.1 nM, respectively.{33248} It inhibits ERK-dependent p90RSK serine 380 phosphorylation in PMA-stimulated HepG2 cells with an IC50 value of 12 nM. GDC-0994 inhibited growth of HCT116 human colorectal cancer xenograft tumors by 49%, 57%, and 80% at 30, 60, and 100 mg/kg, respectively, when administered orally once daily for 21 days.{33248}
Brand:CaymanSKU:21107 -Out of stock
GDC-0994 is a potent and selective ERK1 and ERK2 inhibitor with IC50 values of 6.1 and 4.1 nM, respectively.{33248} It inhibits ERK-dependent p90RSK serine 380 phosphorylation in PMA-stimulated HepG2 cells with an IC50 value of 12 nM. GDC-0994 inhibited growth of HCT116 human colorectal cancer xenograft tumors by 49%, 57%, and 80% at 30, 60, and 100 mg/kg, respectively, when administered orally once daily for 21 days.{33248}
Brand:CaymanSKU:21107 -Out of stock
GDC-0994 is a potent and selective ERK1 and ERK2 inhibitor with IC50 values of 6.1 and 4.1 nM, respectively.{33248} It inhibits ERK-dependent p90RSK serine 380 phosphorylation in PMA-stimulated HepG2 cells with an IC50 value of 12 nM. GDC-0994 inhibited growth of HCT116 human colorectal cancer xenograft tumors by 49%, 57%, and 80% at 30, 60, and 100 mg/kg, respectively, when administered orally once daily for 21 days.{33248}
Brand:CaymanSKU:21107 -Out of stock
Gedunin is a natural inhibitor of the heat shock protein (Hsp90; Item Nos. 22734 | 22735) co-chaperone p23 that also inhibits Hsp90 expression in human teratocarcinomal NTERA-2 cells in vitro at 5 µg/ml.{35153} This tetranortriterpenoid, which is isolated from A. indica, binds to and blocks the chaperone activity of p23 to induce apoptosis in HeLa-PRB cells in vitro at a concentration of 20 µM.{35151} Gedunin inhibits breast cancer cell proliferation in vitro, with IC50 values of 8.84 and 3.22 µM in MCF-7 and SKBr-3 cells, respectively, and inhibits the growth of PANC-1 pancreatic cancer cells (IC50 = 25 µM) by targeting the sonic hedgehog pathway to induce apoptosis.{35147,35152} It also exerts anti-inflammatory effects in vivo. In a mouse model of articular inflammation induced by zymosan (Item No. 21175), gedunin (0.05-0.5 mg/kg, i.p.) reduces edema formation and the production of inflammatory cytokines.{35149} Gedunin (0.5 mg/kg) also inhibits the pleural accumulation of eosinophils and activated T lymphocytes in an ovalbumin-sensitized mouse model of allergic inflammation when administered prior to ovalbumin rechallenge.{35150} It also targets the lipopolysaccharide binding site and thus blocks Toll-like receptor 4 (TLR4) signaling in macrophages in vitro at a concentration of 10 µM.{35145}
Brand:CaymanSKU:-Available on backorder
Gefitinib is a selective EGFR-TK inhibitor that blocks the growth of GEO colon, ZR-75-1, and MCF-10A Ha-ras breast, and OVCAR-3 ovarian cancer cell lines with IC50 values of 0.2-0.4 µM.{17856} By interfering with the intracellular kinase domain, gefitinib prevents EGFR autophosphorylation and prevents downstream signal transduction. Formulations containing gefitinib were previously used to treat advanced (or recurrent) non-small cell lung cancer. However, the FDA retracted its general approval when a phase III trial failed to demonstrate an overall survival benefit.{17857} Formulations containing gefitinib appear to be most efficacious in treating certain EGFR gene mutations prevalent in Asian populations.{17858,17859}
Brand:CaymanSKU:- Gefitinib is a selective EGFR-TK inhibitor that blocks the growth of GEO colon, ZR-75-1, and MCF-10A Ha-ras breast, and OVCAR-3 ovarian cancer cell lines with IC50 values of 0.2-0.4 µM.{17856} By interfering with the intracellular kinase domain, gefitinib prevents EGFR autophosphorylation and prevents downstream signal transduction. Formulations containing gefitinib were previously used to treat advanced (or recurrent) non-small cell lung cancer. However, the FDA retracted its general approval when a phase III trial failed to demonstrate an overall survival benefit.{17857} Formulations containing gefitinib appear to be most efficacious in treating certain EGFR gene mutations prevalent in Asian populations.{17858,17859}
Brand:CaymanSKU:- Gefitinib is a selective EGFR-TK inhibitor that blocks the growth of GEO colon, ZR-75-1, and MCF-10A Ha-ras breast, and OVCAR-3 ovarian cancer cell lines with IC50 values of 0.2-0.4 µM.{17856} By interfering with the intracellular kinase domain, gefitinib prevents EGFR autophosphorylation and prevents downstream signal transduction. Formulations containing gefitinib were previously used to treat advanced (or recurrent) non-small cell lung cancer. However, the FDA retracted its general approval when a phase III trial failed to demonstrate an overall survival benefit.{17857} Formulations containing gefitinib appear to be most efficacious in treating certain EGFR gene mutations prevalent in Asian populations.{17858,17859}
Brand:CaymanSKU:- Gefitinib is a selective EGFR-TK inhibitor that blocks the growth of GEO colon, ZR-75-1, and MCF-10A Ha-ras breast, and OVCAR-3 ovarian cancer cell lines with IC50 values of 0.2-0.4 µM.{17856} By interfering with the intracellular kinase domain, gefitinib prevents EGFR autophosphorylation and prevents downstream signal transduction. Formulations containing gefitinib were previously used to treat advanced (or recurrent) non-small cell lung cancer. However, the FDA retracted its general approval when a phase III trial failed to demonstrate an overall survival benefit.{17857} Formulations containing gefitinib appear to be most efficacious in treating certain EGFR gene mutations prevalent in Asian populations.{17858,17859}
Brand:CaymanSKU:-
Gefitinib-based PROTAC 3 is a proteolysis-targeting chimera (PROTAC) comprised of the EGF receptor (EGFR) inhibitor gefitinib (Item No. 13166) linked to the von Hippel-Lindau (VHL) E3 ubiquitin ligase ligand VHL ligand 1 (Item No. 21591).{52051} In cell-based assays, gefitinib-based PROTAC 3 induces degradation of EGFR containing the activating mutation L858R or an exon 19 deletion with half-maximal degradation (DC50) values of 22.3 and 11.7 nM, respectively, but does not induce degradation of wild-type EGFR at concentrations up to 10 μM.
Brand:CaymanSKU:28597 - 1 mgAvailable on backorder
Gefitinib-based PROTAC 3 is a proteolysis-targeting chimera (PROTAC) comprised of the EGF receptor (EGFR) inhibitor gefitinib (Item No. 13166) linked to the von Hippel-Lindau (VHL) E3 ubiquitin ligase ligand VHL ligand 1 (Item No. 21591).{52051} In cell-based assays, gefitinib-based PROTAC 3 induces degradation of EGFR containing the activating mutation L858R or an exon 19 deletion with half-maximal degradation (DC50) values of 22.3 and 11.7 nM, respectively, but does not induce degradation of wild-type EGFR at concentrations up to 10 μM.
Brand:CaymanSKU:28597 - 10 mgAvailable on backorder
Gefitinib-based PROTAC 3 is a proteolysis-targeting chimera (PROTAC) comprised of the EGF receptor (EGFR) inhibitor gefitinib (Item No. 13166) linked to the von Hippel-Lindau (VHL) E3 ubiquitin ligase ligand VHL ligand 1 (Item No. 21591).{52051} In cell-based assays, gefitinib-based PROTAC 3 induces degradation of EGFR containing the activating mutation L858R or an exon 19 deletion with half-maximal degradation (DC50) values of 22.3 and 11.7 nM, respectively, but does not induce degradation of wild-type EGFR at concentrations up to 10 μM.
Brand:CaymanSKU:28597 - 25 mgAvailable on backorder
Gefitinib-based PROTAC 3 is a proteolysis-targeting chimera (PROTAC) comprised of the EGF receptor (EGFR) inhibitor gefitinib (Item No. 13166) linked to the von Hippel-Lindau (VHL) E3 ubiquitin ligase ligand VHL ligand 1 (Item No. 21591).{52051} In cell-based assays, gefitinib-based PROTAC 3 induces degradation of EGFR containing the activating mutation L858R or an exon 19 deletion with half-maximal degradation (DC50) values of 22.3 and 11.7 nM, respectively, but does not induce degradation of wild-type EGFR at concentrations up to 10 μM.
Brand:CaymanSKU:28597 - 5 mgAvailable on backorder
Gefitinib-d6 is intended for use as an internal standard for the quantification of gefitinib (Item No. 13166) by GC- or LC-MS. Gefitinib is a selective EGFR-TK inhibitor that blocks the growth of GEO colon cancer, ZR-75-1 and MCF-10A Ha-ras breast cancer, and OVCAR-3 ovarian cancer cell lines with IC50s ranging between 0.2-0.4 µM.{17856} By interfering with the intracellular kinase domain, gefitinib prevents EGFR autophosphorylation and prevents downstream signal transduction. Formulations containing gefitinib were previously used to treat advanced (or recurrent) non-small cell lung cancer. However, the FDA retracted its general approval when a phase III trial failed to demonstrate an overall survival benefit.{17857} Formulations containing gefitinib appear to be most efficacious in treating certain EGFR gene mutations prevalent in Asian populations.{17858,17859}
Brand:CaymanSKU:22364 -Out of stock
Gefitinib-d6 is intended for use as an internal standard for the quantification of gefitinib (Item No. 13166) by GC- or LC-MS. Gefitinib is a selective EGFR-TK inhibitor that blocks the growth of GEO colon cancer, ZR-75-1 and MCF-10A Ha-ras breast cancer, and OVCAR-3 ovarian cancer cell lines with IC50s ranging between 0.2-0.4 µM.{17856} By interfering with the intracellular kinase domain, gefitinib prevents EGFR autophosphorylation and prevents downstream signal transduction. Formulations containing gefitinib were previously used to treat advanced (or recurrent) non-small cell lung cancer. However, the FDA retracted its general approval when a phase III trial failed to demonstrate an overall survival benefit.{17857} Formulations containing gefitinib appear to be most efficacious in treating certain EGFR gene mutations prevalent in Asian populations.{17858,17859}
Brand:CaymanSKU:22364 -Out of stock
Geldanamycin is a benzoquinone ansamycin antibiotic which binds heat shock protein 90 (Hsp90) and its paralog GRP94, altering their actions.{15573,18242,18246} Through its interaction with these chaperones, geldanamycin indirectly affects numerous client proteins with roles in diverse cellular processes, including gene expression, cell proliferation, apoptosis, and angiogenesis. For example, geldanamycin inhibits c-jun expression in human colon adenocarcinoma HT29 cells (IC50 = 75 nM), inhibiting AP-1 binding.{18245} It also reduces signaling through mitogenic signaling proteins and interferes with steroid receptor function.{15573,18247,18243,18244} Inhibitors of Hsp90, including geldanamycin, show promise in cancer therapy.{18248}
Brand:CaymanSKU:- Geldanamycin is a benzoquinone ansamycin antibiotic which binds heat shock protein 90 (Hsp90) and its paralog GRP94, altering their actions.{15573,18242,18246} Through its interaction with these chaperones, geldanamycin indirectly affects numerous client proteins with roles in diverse cellular processes, including gene expression, cell proliferation, apoptosis, and angiogenesis. For example, geldanamycin inhibits c-jun expression in human colon adenocarcinoma HT29 cells (IC50 = 75 nM), inhibiting AP-1 binding.{18245} It also reduces signaling through mitogenic signaling proteins and interferes with steroid receptor function.{15573,18247,18243,18244} Inhibitors of Hsp90, including geldanamycin, show promise in cancer therapy.{18248}
Brand:CaymanSKU:- Geldanamycin is a benzoquinone ansamycin antibiotic which binds heat shock protein 90 (Hsp90) and its paralog GRP94, altering their actions.{15573,18242,18246} Through its interaction with these chaperones, geldanamycin indirectly affects numerous client proteins with roles in diverse cellular processes, including gene expression, cell proliferation, apoptosis, and angiogenesis. For example, geldanamycin inhibits c-jun expression in human colon adenocarcinoma HT29 cells (IC50 = 75 nM), inhibiting AP-1 binding.{18245} It also reduces signaling through mitogenic signaling proteins and interferes with steroid receptor function.{15573,18247,18243,18244} Inhibitors of Hsp90, including geldanamycin, show promise in cancer therapy.{18248}
Brand:CaymanSKU:-
Gemcitabine is an anticancer nucleoside analog that inhibits the growth of HL-60 promyelocytic leukemia cells with an LC50 value of 40 nM.{40344} It inhibits the growth of MX-1 mammary, CX-1, HC-1, GC3, and VRC5 colon, LX-1, Calu-6, and NCI-H460 lung, and HS766T, PaCa-2, PANC-1, and BxPC-3 pancreatic cancer tumors in mouse xenograft models (45-93% inhibition).{40343} Gemcitabine is a prodrug that is metabolized to a diphosphate and triphosphate form in cells. The triphosphate form is incorporated into DNA which induces masked chain termination and cell death.{21021} By specifically inhibiting growth arrest and DNA damage inducible protein 45 a (Gadd45a), a key mediator of active DNA demethylation, gemcitabine, at concentrations ranging from 34 to 134 nM, inhibits repair-mediated DNA demethylation in a methylation-sensitive reporter assay. Gemcitabine also has broad antiretroviral activity, decreasing MuLV cell infectivity, a murine AIDS model, in cell culture (EC50 = ~1.5 nM) and inhibits the progression of murine AIDS in vivo at a dose of 1-2 mg/kg per day.{21022}
Brand:CaymanSKU:11690 - 10 mgAvailable on backorder
Gemcitabine is an anticancer nucleoside analog that inhibits the growth of HL-60 promyelocytic leukemia cells with an LC50 value of 40 nM.{40344} It inhibits the growth of MX-1 mammary, CX-1, HC-1, GC3, and VRC5 colon, LX-1, Calu-6, and NCI-H460 lung, and HS766T, PaCa-2, PANC-1, and BxPC-3 pancreatic cancer tumors in mouse xenograft models (45-93% inhibition).{40343} Gemcitabine is a prodrug that is metabolized to a diphosphate and triphosphate form in cells. The triphosphate form is incorporated into DNA which induces masked chain termination and cell death.{21021} By specifically inhibiting growth arrest and DNA damage inducible protein 45 a (Gadd45a), a key mediator of active DNA demethylation, gemcitabine, at concentrations ranging from 34 to 134 nM, inhibits repair-mediated DNA demethylation in a methylation-sensitive reporter assay. Gemcitabine also has broad antiretroviral activity, decreasing MuLV cell infectivity, a murine AIDS model, in cell culture (EC50 = ~1.5 nM) and inhibits the progression of murine AIDS in vivo at a dose of 1-2 mg/kg per day.{21022}
Brand:CaymanSKU:11690 - 100 mgAvailable on backorder
Gemcitabine is an anticancer nucleoside analog that inhibits the growth of HL-60 promyelocytic leukemia cells with an LC50 value of 40 nM.{40344} It inhibits the growth of MX-1 mammary, CX-1, HC-1, GC3, and VRC5 colon, LX-1, Calu-6, and NCI-H460 lung, and HS766T, PaCa-2, PANC-1, and BxPC-3 pancreatic cancer tumors in mouse xenograft models (45-93% inhibition).{40343} Gemcitabine is a prodrug that is metabolized to a diphosphate and triphosphate form in cells. The triphosphate form is incorporated into DNA which induces masked chain termination and cell death.{21021} By specifically inhibiting growth arrest and DNA damage inducible protein 45 a (Gadd45a), a key mediator of active DNA demethylation, gemcitabine, at concentrations ranging from 34 to 134 nM, inhibits repair-mediated DNA demethylation in a methylation-sensitive reporter assay. Gemcitabine also has broad antiretroviral activity, decreasing MuLV cell infectivity, a murine AIDS model, in cell culture (EC50 = ~1.5 nM) and inhibits the progression of murine AIDS in vivo at a dose of 1-2 mg/kg per day.{21022}
Brand:CaymanSKU:11690 - 25 mgAvailable on backorder
Gemcitabine is an anticancer nucleoside analog that inhibits the growth of HL-60 promyelocytic leukemia cells with an LC50 value of 40 nM.{40344} It inhibits the growth of MX-1 mammary, CX-1, HC-1, GC3, and VRC5 colon, LX-1, Calu-6, and NCI-H460 lung, and HS766T, PaCa-2, PANC-1, and BxPC-3 pancreatic cancer tumors in mouse xenograft models (45-93% inhibition).{40343} Gemcitabine is a prodrug that is metabolized to a diphosphate and triphosphate form in cells. The triphosphate form is incorporated into DNA which induces masked chain termination and cell death.{21021} By specifically inhibiting growth arrest and DNA damage inducible protein 45 a (Gadd45a), a key mediator of active DNA demethylation, gemcitabine, at concentrations ranging from 34 to 134 nM, inhibits repair-mediated DNA demethylation in a methylation-sensitive reporter assay. Gemcitabine also has broad antiretroviral activity, decreasing MuLV cell infectivity, a murine AIDS model, in cell culture (EC50 = ~1.5 nM) and inhibits the progression of murine AIDS in vivo at a dose of 1-2 mg/kg per day.{21022}
Brand:CaymanSKU:11690 - 50 mgAvailable on backorder
Gemcitabine is an anticancer nucleoside analog that inhibits the growth of HL-60 promyelocytic leukemia cells with an LC50 value of 40 nM.{40344} It inhibits the growth of MX-1 mammary, CX-1, HC-1, GC3, and VRC5 colon, LX-1, Calu-6, and NCI-H460 lung, and HS766T, PaCa-2, PANC-1, and BxPC-3 pancreatic cancer tumors in mouse xenograft models (45-93% inhibition).{40343} Gemcitabine is a prodrug that is metabolized to a diphosphate and triphosphate form in cells. The triphosphate form is incorporated into DNA which induces masked chain termination and cell death.{21021} By specifically inhibiting growth arrest and DNA damage inducible protein 45 a (Gadd45a), a key mediator of active DNA demethylation, gemcitabine, at concentrations ranging from 34 to 134 nM, inhibits repair-mediated DNA demethylation in a methylation-sensitive reporter assay. Gemcitabine also has broad antiretroviral activity, decreasing MuLV cell infectivity, a murine AIDS model, in cell culture (EC50 = ~1.5 nM) and inhibits the progression of murine AIDS in vivo at a dose of 1-2 mg/kg per day.{21022}
Brand:CaymanSKU:9003096 - 100 mgAvailable on backorder
Gemcitabine is an anticancer nucleoside analog that inhibits the growth of HL-60 promyelocytic leukemia cells with an LC50 value of 40 nM.{40344} It inhibits the growth of MX-1 mammary, CX-1, HC-1, GC3, and VRC5 colon, LX-1, Calu-6, and NCI-H460 lung, and HS766T, PaCa-2, PANC-1, and BxPC-3 pancreatic cancer tumors in mouse xenograft models (45-93% inhibition).{40343} Gemcitabine is a prodrug that is metabolized to a diphosphate and triphosphate form in cells. The triphosphate form is incorporated into DNA which induces masked chain termination and cell death.{21021} By specifically inhibiting growth arrest and DNA damage inducible protein 45 a (Gadd45a), a key mediator of active DNA demethylation, gemcitabine, at concentrations ranging from 34 to 134 nM, inhibits repair-mediated DNA demethylation in a methylation-sensitive reporter assay. Gemcitabine also has broad antiretroviral activity, decreasing MuLV cell infectivity, a murine AIDS model, in cell culture (EC50 = ~1.5 nM) and inhibits the progression of murine AIDS in vivo at a dose of 1-2 mg/kg per day.{21022}
Brand:CaymanSKU:9003096 - 25 mgAvailable on backorder
Gemcitabine is an anticancer nucleoside analog that inhibits the growth of HL-60 promyelocytic leukemia cells with an LC50 value of 40 nM.{40344} It inhibits the growth of MX-1 mammary, CX-1, HC-1, GC3, and VRC5 colon, LX-1, Calu-6, and NCI-H460 lung, and HS766T, PaCa-2, PANC-1, and BxPC-3 pancreatic cancer tumors in mouse xenograft models (45-93% inhibition).{40343} Gemcitabine is a prodrug that is metabolized to a diphosphate and triphosphate form in cells. The triphosphate form is incorporated into DNA which induces masked chain termination and cell death.{21021} By specifically inhibiting growth arrest and DNA damage inducible protein 45 a (Gadd45a), a key mediator of active DNA demethylation, gemcitabine, at concentrations ranging from 34 to 134 nM, inhibits repair-mediated DNA demethylation in a methylation-sensitive reporter assay. Gemcitabine also has broad antiretroviral activity, decreasing MuLV cell infectivity, a murine AIDS model, in cell culture (EC50 = ~1.5 nM) and inhibits the progression of murine AIDS in vivo at a dose of 1-2 mg/kg per day.{21022}
Brand:CaymanSKU:9003096 - 50 mgAvailable on backorder
Gemcitabine elaidate is a lipophilic prodrug form of the nucleoside analog gemcitabine (Item Nos. 11690 | 9003096) that contains an elaidic acid (Item No. 90250) moiety.{47590} Gemcitabine elaidate inhibits growth of gemcitabine-sensitive L1210/L5, BCLO, and A2780 cells (IC50s = 0.0033, 0.0042, and 0.0025 µM, respectively) but not cytarabine-resistant L4A6 and Bara-C cells (IC50s = 16 and 13 µM, respectively) or gemcitabine-resistant AG6000 cells (IC50 = 91 µM). It inhibits growth of THX, LOX, MOLT-4, and MOLT-4/C8 cells in a manner independent of nucleoside transport. Gemcitabine elaidate reduces tumor growth in EKVX non-small cell lung cancer and MHMX sarcoma mouse xenograft models but not in an H-146 small cell lung cancer mouse xenograft model when administered at a dose of 40 mg/kg every three days.
Brand:CaymanSKU:28303 - 1 mgAvailable on backorder
Gemcitabine elaidate is a lipophilic prodrug form of the nucleoside analog gemcitabine (Item Nos. 11690 | 9003096) that contains an elaidic acid (Item No. 90250) moiety.{47590} Gemcitabine elaidate inhibits growth of gemcitabine-sensitive L1210/L5, BCLO, and A2780 cells (IC50s = 0.0033, 0.0042, and 0.0025 µM, respectively) but not cytarabine-resistant L4A6 and Bara-C cells (IC50s = 16 and 13 µM, respectively) or gemcitabine-resistant AG6000 cells (IC50 = 91 µM). It inhibits growth of THX, LOX, MOLT-4, and MOLT-4/C8 cells in a manner independent of nucleoside transport. Gemcitabine elaidate reduces tumor growth in EKVX non-small cell lung cancer and MHMX sarcoma mouse xenograft models but not in an H-146 small cell lung cancer mouse xenograft model when administered at a dose of 40 mg/kg every three days.
Brand:CaymanSKU:28303 - 10 mgAvailable on backorder
Gemcitabine elaidate is a lipophilic prodrug form of the nucleoside analog gemcitabine (Item Nos. 11690 | 9003096) that contains an elaidic acid (Item No. 90250) moiety.{47590} Gemcitabine elaidate inhibits growth of gemcitabine-sensitive L1210/L5, BCLO, and A2780 cells (IC50s = 0.0033, 0.0042, and 0.0025 µM, respectively) but not cytarabine-resistant L4A6 and Bara-C cells (IC50s = 16 and 13 µM, respectively) or gemcitabine-resistant AG6000 cells (IC50 = 91 µM). It inhibits growth of THX, LOX, MOLT-4, and MOLT-4/C8 cells in a manner independent of nucleoside transport. Gemcitabine elaidate reduces tumor growth in EKVX non-small cell lung cancer and MHMX sarcoma mouse xenograft models but not in an H-146 small cell lung cancer mouse xenograft model when administered at a dose of 40 mg/kg every three days.
Brand:CaymanSKU:28303 - 25 mgAvailable on backorder
Gemcitabine elaidate is a lipophilic prodrug form of the nucleoside analog gemcitabine (Item Nos. 11690 | 9003096) that contains an elaidic acid (Item No. 90250) moiety.{47590} Gemcitabine elaidate inhibits growth of gemcitabine-sensitive L1210/L5, BCLO, and A2780 cells (IC50s = 0.0033, 0.0042, and 0.0025 µM, respectively) but not cytarabine-resistant L4A6 and Bara-C cells (IC50s = 16 and 13 µM, respectively) or gemcitabine-resistant AG6000 cells (IC50 = 91 µM). It inhibits growth of THX, LOX, MOLT-4, and MOLT-4/C8 cells in a manner independent of nucleoside transport. Gemcitabine elaidate reduces tumor growth in EKVX non-small cell lung cancer and MHMX sarcoma mouse xenograft models but not in an H-146 small cell lung cancer mouse xenograft model when administered at a dose of 40 mg/kg every three days.
Brand:CaymanSKU:28303 - 5 mgAvailable on backorder
Gemcitabine monophosphate is a monophosphate form of the deoxycytidine analog gemcitabine (Item No. 9003096).{40694} It has synergistic effects when used in nanoparticle form in combination with cisplatin nanoparticles in vitro at a one-to-one molar ratio (IC50s = 5.95 and 34.8 for the nanoparticle combination and gemcitabine monophosphate alone, respectively). In a stroma-rich mouse xenograft model, the nanoparticle combination of gemcitabine and cisplatin inhibits tumor growth and increases apoptosis.
Brand:CaymanSKU:31726 - 1 mgAvailable on backorder
Gemcitabine monophosphate is a monophosphate form of the deoxycytidine analog gemcitabine (Item No. 9003096).{40694} It has synergistic effects when used in nanoparticle form in combination with cisplatin nanoparticles in vitro at a one-to-one molar ratio (IC50s = 5.95 and 34.8 for the nanoparticle combination and gemcitabine monophosphate alone, respectively). In a stroma-rich mouse xenograft model, the nanoparticle combination of gemcitabine and cisplatin inhibits tumor growth and increases apoptosis.
Brand:CaymanSKU:31726 - 500 µgAvailable on backorder
Gemfibrozil is a fibrate that activates peroxisome proliferator-activator α (PPARα, EC50 = 193 μM) with 100% efficacy.{23621} It also activates PPARγ (EC50 = 148 μM), but with only 79% efficacy.{23621} Presumably through its effects on PPARα, gemfibrozil lowers triglycerides and increases high density lipoprotein cholesterol levels and is used in the context of atherogenic dyslipidemia.{23620} Gemfibrozil strongly binds liver fatty acid-binding protein (Ki = 1.8 μM).{23622} Phase II metabolites of gemfibrozil inhibit certain cytochrome P450 isoforms, increasing drug-drug interaction risks.{23619}
Brand:CaymanSKU:- Gemfibrozil is a fibrate that activates peroxisome proliferator-activator α (PPARα, EC50 = 193 μM) with 100% efficacy.{23621} It also activates PPARγ (EC50 = 148 μM), but with only 79% efficacy.{23621} Presumably through its effects on PPARα, gemfibrozil lowers triglycerides and increases high density lipoprotein cholesterol levels and is used in the context of atherogenic dyslipidemia.{23620} Gemfibrozil strongly binds liver fatty acid-binding protein (Ki = 1.8 μM).{23622} Phase II metabolites of gemfibrozil inhibit certain cytochrome P450 isoforms, increasing drug-drug interaction risks.{23619}
Brand:CaymanSKU:- Gemfibrozil is a fibrate that activates peroxisome proliferator-activator α (PPARα, EC50 = 193 μM) with 100% efficacy.{23621} It also activates PPARγ (EC50 = 148 μM), but with only 79% efficacy.{23621} Presumably through its effects on PPARα, gemfibrozil lowers triglycerides and increases high density lipoprotein cholesterol levels and is used in the context of atherogenic dyslipidemia.{23620} Gemfibrozil strongly binds liver fatty acid-binding protein (Ki = 1.8 μM).{23622} Phase II metabolites of gemfibrozil inhibit certain cytochrome P450 isoforms, increasing drug-drug interaction risks.{23619}
Brand:CaymanSKU:- Gemfibrozil is a fibrate that activates peroxisome proliferator-activator α (PPARα, EC50 = 193 μM) with 100% efficacy.{23621} It also activates PPARγ (EC50 = 148 μM), but with only 79% efficacy.{23621} Presumably through its effects on PPARα, gemfibrozil lowers triglycerides and increases high density lipoprotein cholesterol levels and is used in the context of atherogenic dyslipidemia.{23620} Gemfibrozil strongly binds liver fatty acid-binding protein (Ki = 1.8 μM).{23622} Phase II metabolites of gemfibrozil inhibit certain cytochrome P450 isoforms, increasing drug-drug interaction risks.{23619}
Brand:CaymanSKU:-
Gemfibrozil 1-O-β-glucuronide is a major metabolite of gemfibrozil (Item No. 14835) that is formed when gemfibrozil undergoes glucuronidation by UDP-glucuronosyltransferase (UGT) 2B7.{37643} Gemfibrozil 1-O-β-glucuronide is an inhibitor of the cytochrome P450 (CYP) isoform CYP2C8 (IC50 = 4.1 µM). It is taken up by organic anion transporting polypeptide 1B1 (OATP1B1) in sandwich cultured human hepatocytes (SCHHs) and inhibits cellular uptake of valsartan (Item No. 14178) in MDCK cells expressing OATP1B1 (IC50 = 20.4 µM).{37644,37645}
Brand:CaymanSKU:-Available on backorder
Gemfibrozil 1-O-β-glucuronide is a major metabolite of gemfibrozil (Item No. 14835) that is formed when gemfibrozil undergoes glucuronidation by UDP-glucuronosyltransferase (UGT) 2B7.{37643} Gemfibrozil 1-O-β-glucuronide is an inhibitor of the cytochrome P450 (CYP) isoform CYP2C8 (IC50 = 4.1 µM). It is taken up by organic anion transporting polypeptide 1B1 (OATP1B1) in sandwich cultured human hepatocytes (SCHHs) and inhibits cellular uptake of valsartan (Item No. 14178) in MDCK cells expressing OATP1B1 (IC50 = 20.4 µM).{37644,37645}
Brand:CaymanSKU:-Available on backorder
Gemfibrozil-d6 is intended for use as an internal standard for the quantification of gemfibrozil (Item No. 14835) by GC- or LC-MS. Gemfibrozil is a peroxisome proliferator-activated reporter α (PPARα) and PPARγ agonist (EC50s = 193.3 and 147.8 µM, respectively, in transactivation assays).{23621} In vivo, gemfibrozil (50 mg/kg, p.o.) reduces serum total cholesterol, triglyceride, and LDL levels in a rat model of high-cholesterol diet-induced hyperlipidemia.{54664} Gemfibrozil (100 mg/kg per day) reduces atherosclerotic plaque area, superoxide production, and expression of the genes encoding the NF-κB subunit p65 and chemokine (C-C) motif ligand 2 (CCL2) in ApoE-/- mice.{54665} Formulations containing gemfibrozil have been used in the treatment of high cholesterol.
Brand:CaymanSKU:31915 - 1 mgAvailable on backorder
Gemfibrozil-d6 is intended for use as an internal standard for the quantification of gemfibrozil (Item No. 14835) by GC- or LC-MS. Gemfibrozil is a peroxisome proliferator-activated reporter α (PPARα) and PPARγ agonist (EC50s = 193.3 and 147.8 µM, respectively, in transactivation assays).{23621} In vivo, gemfibrozil (50 mg/kg, p.o.) reduces serum total cholesterol, triglyceride, and LDL levels in a rat model of high-cholesterol diet-induced hyperlipidemia.{54664} Gemfibrozil (100 mg/kg per day) reduces atherosclerotic plaque area, superoxide production, and expression of the genes encoding the NF-κB subunit p65 and chemokine (C-C) motif ligand 2 (CCL2) in ApoE-/- mice.{54665} Formulations containing gemfibrozil have been used in the treatment of high cholesterol.
Brand:CaymanSKU:31915 - 500 µgAvailable on backorder
Gemifloxacin is a fluoroquinolone antibiotic that is effective against C. pneumoniae and M. tuberculosis (MIC50s = 0.25 and 8 µg/ml, respectively).{29636,33222} Quinolones, including gemifloxacin, inhibit bacterial DNA gyrase and other topoisomerases.{27399,27494} Formulations containing gemifloxacin are useful against respiratory tract infections, particularly community-acquired pneumonia and tuberculosis.{29636,33220,33221}
Brand:CaymanSKU:21047 -Out of stock
Gemifloxacin is a fluoroquinolone antibiotic that is effective against C. pneumoniae and M. tuberculosis (MIC50s = 0.25 and 8 µg/ml, respectively).{29636,33222} Quinolones, including gemifloxacin, inhibit bacterial DNA gyrase and other topoisomerases.{27399,27494} Formulations containing gemifloxacin are useful against respiratory tract infections, particularly community-acquired pneumonia and tuberculosis.{29636,33220,33221}
Brand:CaymanSKU:21047 -Out of stock
Gemifloxacin is a fluoroquinolone antibiotic that is effective against C. pneumoniae and M. tuberculosis (MIC50s = 0.25 and 8 µg/ml, respectively).{29636,33222} Quinolones, including gemifloxacin, inhibit bacterial DNA gyrase and other topoisomerases.{27399,27494} Formulations containing gemifloxacin are useful against respiratory tract infections, particularly community-acquired pneumonia and tuberculosis.{29636,33220,33221}
Brand:CaymanSKU:21047 -Out of stock
Gemifloxacin is a fluoroquinolone antibiotic that is effective against C. pneumoniae and M. tuberculosis (MIC50s = 0.25 and 8 µg/ml, respectively).{29636,33222} Quinolones, including gemifloxacin, inhibit bacterial DNA gyrase and other topoisomerases.{27399,27494} Formulations containing gemifloxacin are useful against respiratory tract infections, particularly community-acquired pneumonia and tuberculosis.{29636,33220,33221}
Brand:CaymanSKU:21047 -Out of stock
Geninthiocin A is a cyclic thiopeptide bacterial metabolite originally isolated from Streptomyces sp. DD84.{42770} It is active against a variety of Gram-positive bacteria (MICs = 0.2-4 µg/ml), the Gram-negative bacterium C. violaceum (MIC = 19 µg/ml), and the fungus M. hiemalis (MIC = 38 µg/ml).{42771} Geninthiocin A also induces tipA promoter transcription with a minimum induction concentration of 1.2 ng/ml.{42770}
Brand:CaymanSKU:28125 - 2.5 mgAvailable on backorder
Geninthiocin A is a cyclic thiopeptide bacterial metabolite originally isolated from Streptomyces sp. DD84.{42770} It is active against a variety of Gram-positive bacteria (MICs = 0.2-4 µg/ml), the Gram-negative bacterium C. violaceum (MIC = 19 µg/ml), and the fungus M. hiemalis (MIC = 38 µg/ml).{42771} Geninthiocin A also induces tipA promoter transcription with a minimum induction concentration of 1.2 ng/ml.{42770}
Brand:CaymanSKU:28125 - 500 µgAvailable on backorder
Uncoupling protein 2 (UCP2) is a mitochondrial carrier protein that is expressed in pancreatic islets and has been shown to negatively regulate glucose-stimulated insulin secretion.{15659,15658} High levels of UCP2 expression can disrupt pancreatic β cell function and downregulate insulin secretion thereby contributing to the development of type 2 diabetes.{15660} Genipin, a compound isolated from Gardenis jasminoides Ellis fruits, was originally identified as a protein cross-linking agent. Genipin is a cell-permeable inhibitor of UCP2 activity.{15075} Genipin, at 5 µM, increases glucose-stimulated insulin secretion in isolated pancreatic islets chronically exposed to high levels of glucose.{15661} Genipin also exhibits anti-inflammatory and anti-angiogenic properties by inducing apoptosis in FaO rat hepatoma cells and human hepatocarcinoma Hep3B cells.{15662}
Brand:CaymanSKU:10010622 - 10 mgAvailable on backorder
Uncoupling protein 2 (UCP2) is a mitochondrial carrier protein that is expressed in pancreatic islets and has been shown to negatively regulate glucose-stimulated insulin secretion.{15659,15658} High levels of UCP2 expression can disrupt pancreatic β cell function and downregulate insulin secretion thereby contributing to the development of type 2 diabetes.{15660} Genipin, a compound isolated from Gardenis jasminoides Ellis fruits, was originally identified as a protein cross-linking agent. Genipin is a cell-permeable inhibitor of UCP2 activity.{15075} Genipin, at 5 µM, increases glucose-stimulated insulin secretion in isolated pancreatic islets chronically exposed to high levels of glucose.{15661} Genipin also exhibits anti-inflammatory and anti-angiogenic properties by inducing apoptosis in FaO rat hepatoma cells and human hepatocarcinoma Hep3B cells.{15662}
Brand:CaymanSKU:10010622 - 25 mgAvailable on backorder
Uncoupling protein 2 (UCP2) is a mitochondrial carrier protein that is expressed in pancreatic islets and has been shown to negatively regulate glucose-stimulated insulin secretion.{15659,15658} High levels of UCP2 expression can disrupt pancreatic β cell function and downregulate insulin secretion thereby contributing to the development of type 2 diabetes.{15660} Genipin, a compound isolated from Gardenis jasminoides Ellis fruits, was originally identified as a protein cross-linking agent. Genipin is a cell-permeable inhibitor of UCP2 activity.{15075} Genipin, at 5 µM, increases glucose-stimulated insulin secretion in isolated pancreatic islets chronically exposed to high levels of glucose.{15661} Genipin also exhibits anti-inflammatory and anti-angiogenic properties by inducing apoptosis in FaO rat hepatoma cells and human hepatocarcinoma Hep3B cells.{15662}
Brand:CaymanSKU:10010622 - 5 mgAvailable on backorder
Uncoupling protein 2 (UCP2) is a mitochondrial carrier protein that is expressed in pancreatic islets and has been shown to negatively regulate glucose-stimulated insulin secretion.{15659,15658} High levels of UCP2 expression can disrupt pancreatic β cell function and downregulate insulin secretion thereby contributing to the development of type 2 diabetes.{15660} Genipin, a compound isolated from Gardenis jasminoides Ellis fruits, was originally identified as a protein cross-linking agent. Genipin is a cell-permeable inhibitor of UCP2 activity.{15075} Genipin, at 5 µM, increases glucose-stimulated insulin secretion in isolated pancreatic islets chronically exposed to high levels of glucose.{15661} Genipin also exhibits anti-inflammatory and anti-angiogenic properties by inducing apoptosis in FaO rat hepatoma cells and human hepatocarcinoma Hep3B cells.{15662}
Brand:CaymanSKU:10010622 - 50 mgAvailable on backorder
Geniposide is an iridoid glycoside that has been found in G. jasmonoides fruit and has diverse biological activities.{50311,50312,50313} It reduces exudate volume and nitrite levels in a rat model of carrageenan-induced air pouch inflammation when administered at a dose of 0.1 mg/pouch.{50311} Geniposide (100 mg/kg, p.o.) prevents carrageenan-induced paw edema in rats. It reduces serum levels of alanine transaminase (ALT) and aspartate aminotransferase (AST) and hepatic levels of malondialdehyde (MDA), as well as increases hepatic levels of superoxide dismutase (SOD) and glutathione peroxidase (GPX) in a rat model of high-fat diet-induced nonalcoholic steatohepatitis (NASH) when administered at doses of 50 and 100 mg/kg.{50312} Geniposide (100 mg/kg) prevents increases in apoptosis and decreases in the number of dopaminergic neurons in the substantia nigra in a mouse model of MPTP-induced Parkinson’s disease.{50313} It also improves motor coordination in the rotarod and swim tests in a rat model of Parkinson’s disease.
Brand:CaymanSKU:28281 - 100 mgAvailable on backorder
Geniposide is an iridoid glycoside that has been found in G. jasmonoides fruit and has diverse biological activities.{50311,50312,50313} It reduces exudate volume and nitrite levels in a rat model of carrageenan-induced air pouch inflammation when administered at a dose of 0.1 mg/pouch.{50311} Geniposide (100 mg/kg, p.o.) prevents carrageenan-induced paw edema in rats. It reduces serum levels of alanine transaminase (ALT) and aspartate aminotransferase (AST) and hepatic levels of malondialdehyde (MDA), as well as increases hepatic levels of superoxide dismutase (SOD) and glutathione peroxidase (GPX) in a rat model of high-fat diet-induced nonalcoholic steatohepatitis (NASH) when administered at doses of 50 and 100 mg/kg.{50312} Geniposide (100 mg/kg) prevents increases in apoptosis and decreases in the number of dopaminergic neurons in the substantia nigra in a mouse model of MPTP-induced Parkinson’s disease.{50313} It also improves motor coordination in the rotarod and swim tests in a rat model of Parkinson’s disease.
Brand:CaymanSKU:28281 - 250 mgAvailable on backorder
Geniposide is an iridoid glycoside that has been found in G. jasmonoides fruit and has diverse biological activities.{50311,50312,50313} It reduces exudate volume and nitrite levels in a rat model of carrageenan-induced air pouch inflammation when administered at a dose of 0.1 mg/pouch.{50311} Geniposide (100 mg/kg, p.o.) prevents carrageenan-induced paw edema in rats. It reduces serum levels of alanine transaminase (ALT) and aspartate aminotransferase (AST) and hepatic levels of malondialdehyde (MDA), as well as increases hepatic levels of superoxide dismutase (SOD) and glutathione peroxidase (GPX) in a rat model of high-fat diet-induced nonalcoholic steatohepatitis (NASH) when administered at doses of 50 and 100 mg/kg.{50312} Geniposide (100 mg/kg) prevents increases in apoptosis and decreases in the number of dopaminergic neurons in the substantia nigra in a mouse model of MPTP-induced Parkinson’s disease.{50313} It also improves motor coordination in the rotarod and swim tests in a rat model of Parkinson’s disease.
Brand:CaymanSKU:28281 - 50 mgAvailable on backorder
Geniposide is an iridoid glycoside that has been found in G. jasmonoides fruit and has diverse biological activities.{50311,50312,50313} It reduces exudate volume and nitrite levels in a rat model of carrageenan-induced air pouch inflammation when administered at a dose of 0.1 mg/pouch.{50311} Geniposide (100 mg/kg, p.o.) prevents carrageenan-induced paw edema in rats. It reduces serum levels of alanine transaminase (ALT) and aspartate aminotransferase (AST) and hepatic levels of malondialdehyde (MDA), as well as increases hepatic levels of superoxide dismutase (SOD) and glutathione peroxidase (GPX) in a rat model of high-fat diet-induced nonalcoholic steatohepatitis (NASH) when administered at doses of 50 and 100 mg/kg.{50312} Geniposide (100 mg/kg) prevents increases in apoptosis and decreases in the number of dopaminergic neurons in the substantia nigra in a mouse model of MPTP-induced Parkinson’s disease.{50313} It also improves motor coordination in the rotarod and swim tests in a rat model of Parkinson’s disease.
Brand:CaymanSKU:28281 - 500 mgAvailable on backorder
Geniposidic acid is an iridoid glycoside that has been found in G. jasminoides and has diverse biological activities.{46445,46444,46446} It inhibits ear edema induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in mice by 91.01% when administered topically at a dose of 0.1 mg/ear.{46445} Geniposidic acid (50 mg/kg) increases survival rate, attenuates increases in alanine aminotransferase (ALT) activity and TNF-α levels in serum, as well as hepatic levels of malondialdehyde (MDA), and prevents decreases in hepatic GSH levels in a mouse model of fulminant hepatic failure induced by D-galactosamine (Item No. 22981) and LPS.{46444} It decreases systolic blood pressure and heart rate and increases plasma levels of atrial natriuretic peptide (ANP; Item Nos. 24276 | 24539) in spontaneously hypertensive rats when administered at a dose of 100 mg/kg.{46446}
Brand:CaymanSKU:28409 - 10 mgAvailable on backorder
Geniposidic acid is an iridoid glycoside that has been found in G. jasminoides and has diverse biological activities.{46445,46444,46446} It inhibits ear edema induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in mice by 91.01% when administered topically at a dose of 0.1 mg/ear.{46445} Geniposidic acid (50 mg/kg) increases survival rate, attenuates increases in alanine aminotransferase (ALT) activity and TNF-α levels in serum, as well as hepatic levels of malondialdehyde (MDA), and prevents decreases in hepatic GSH levels in a mouse model of fulminant hepatic failure induced by D-galactosamine (Item No. 22981) and LPS.{46444} It decreases systolic blood pressure and heart rate and increases plasma levels of atrial natriuretic peptide (ANP; Item Nos. 24276 | 24539) in spontaneously hypertensive rats when administered at a dose of 100 mg/kg.{46446}
Brand:CaymanSKU:28409 - 100 mgAvailable on backorder
Geniposidic acid is an iridoid glycoside that has been found in G. jasminoides and has diverse biological activities.{46445,46444,46446} It inhibits ear edema induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in mice by 91.01% when administered topically at a dose of 0.1 mg/ear.{46445} Geniposidic acid (50 mg/kg) increases survival rate, attenuates increases in alanine aminotransferase (ALT) activity and TNF-α levels in serum, as well as hepatic levels of malondialdehyde (MDA), and prevents decreases in hepatic GSH levels in a mouse model of fulminant hepatic failure induced by D-galactosamine (Item No. 22981) and LPS.{46444} It decreases systolic blood pressure and heart rate and increases plasma levels of atrial natriuretic peptide (ANP; Item Nos. 24276 | 24539) in spontaneously hypertensive rats when administered at a dose of 100 mg/kg.{46446}
Brand:CaymanSKU:28409 - 250 mgAvailable on backorder
Geniposidic acid is an iridoid glycoside that has been found in G. jasminoides and has diverse biological activities.{46445,46444,46446} It inhibits ear edema induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in mice by 91.01% when administered topically at a dose of 0.1 mg/ear.{46445} Geniposidic acid (50 mg/kg) increases survival rate, attenuates increases in alanine aminotransferase (ALT) activity and TNF-α levels in serum, as well as hepatic levels of malondialdehyde (MDA), and prevents decreases in hepatic GSH levels in a mouse model of fulminant hepatic failure induced by D-galactosamine (Item No. 22981) and LPS.{46444} It decreases systolic blood pressure and heart rate and increases plasma levels of atrial natriuretic peptide (ANP; Item Nos. 24276 | 24539) in spontaneously hypertensive rats when administered at a dose of 100 mg/kg.{46446}
Brand:CaymanSKU:28409 - 50 mgAvailable on backorder
Genistein is an isoflavonoid phytoestrogen that has been found in soybeans (G. max/S. hispida) and has kinase inhibitory, anticancer, pro-cancer, hepatoprotective, and antiviral properties.{48101} It inhibits the tyrosine kinases EGFR, pp50v-Src, and pp110gag-fes (IC50s = 6, 7-8, and 6.5 µg/ml, respectively) and decreases EGF-induced serine, threonine, and tyrosine phosphorylation of EGFR in A431 cells when used at a concentration of 20 µg/ml.{12005} Genistein inhibits proliferation and induces apoptosis in a variety of cancer cells, including Bel 7402 hepatocellular carcinoma cells when used at a concentration of 10 µg/ml.{48101,48102} It reduces tumor invasion and angiogenesis in a Bel 7402 mouse subrenal capsule xenograft model when administered at a dose of 50 mg/kg per day.{48102} However, when administered at the same dose on postnatal days 1-5, genistein increases the incidence of uterine adenocarcinoma in a mouse model of cancer induced by the estrogen receptor agonist diethylstilbestrol (DES; Item No. 10006876).{12017} It reduces lipid accumulation and inflammation in the liver of ovariectomized (OVX) and non-OVX female rats in a model of high-fat high-fructose diet-induced nonalcoholic hepatosteatosis (NASH) when administered at a dose of 16 mg/kg per day.{48103} Genistein (10 µM) also inhibits HIV-1 DNA synthesis in resting CD4+ T cells.{52875}
Brand:CaymanSKU:10005167 - 1 gAvailable on backorder
Genistein is an isoflavonoid phytoestrogen that has been found in soybeans (G. max/S. hispida) and has kinase inhibitory, anticancer, pro-cancer, hepatoprotective, and antiviral properties.{48101} It inhibits the tyrosine kinases EGFR, pp50v-Src, and pp110gag-fes (IC50s = 6, 7-8, and 6.5 µg/ml, respectively) and decreases EGF-induced serine, threonine, and tyrosine phosphorylation of EGFR in A431 cells when used at a concentration of 20 µg/ml.{12005} Genistein inhibits proliferation and induces apoptosis in a variety of cancer cells, including Bel 7402 hepatocellular carcinoma cells when used at a concentration of 10 µg/ml.{48101,48102} It reduces tumor invasion and angiogenesis in a Bel 7402 mouse subrenal capsule xenograft model when administered at a dose of 50 mg/kg per day.{48102} However, when administered at the same dose on postnatal days 1-5, genistein increases the incidence of uterine adenocarcinoma in a mouse model of cancer induced by the estrogen receptor agonist diethylstilbestrol (DES; Item No. 10006876).{12017} It reduces lipid accumulation and inflammation in the liver of ovariectomized (OVX) and non-OVX female rats in a model of high-fat high-fructose diet-induced nonalcoholic hepatosteatosis (NASH) when administered at a dose of 16 mg/kg per day.{48103} Genistein (10 µM) also inhibits HIV-1 DNA synthesis in resting CD4+ T cells.{52875}
Brand:CaymanSKU:10005167 - 100 mgAvailable on backorder
Genistein is an isoflavonoid phytoestrogen that has been found in soybeans (G. max/S. hispida) and has kinase inhibitory, anticancer, pro-cancer, hepatoprotective, and antiviral properties.{48101} It inhibits the tyrosine kinases EGFR, pp50v-Src, and pp110gag-fes (IC50s = 6, 7-8, and 6.5 µg/ml, respectively) and decreases EGF-induced serine, threonine, and tyrosine phosphorylation of EGFR in A431 cells when used at a concentration of 20 µg/ml.{12005} Genistein inhibits proliferation and induces apoptosis in a variety of cancer cells, including Bel 7402 hepatocellular carcinoma cells when used at a concentration of 10 µg/ml.{48101,48102} It reduces tumor invasion and angiogenesis in a Bel 7402 mouse subrenal capsule xenograft model when administered at a dose of 50 mg/kg per day.{48102} However, when administered at the same dose on postnatal days 1-5, genistein increases the incidence of uterine adenocarcinoma in a mouse model of cancer induced by the estrogen receptor agonist diethylstilbestrol (DES; Item No. 10006876).{12017} It reduces lipid accumulation and inflammation in the liver of ovariectomized (OVX) and non-OVX female rats in a model of high-fat high-fructose diet-induced nonalcoholic hepatosteatosis (NASH) when administered at a dose of 16 mg/kg per day.{48103} Genistein (10 µM) also inhibits HIV-1 DNA synthesis in resting CD4+ T cells.{52875}
Brand:CaymanSKU:10005167 - 250 mgAvailable on backorder
Genistein is an isoflavonoid phytoestrogen that has been found in soybeans (G. max/S. hispida) and has kinase inhibitory, anticancer, pro-cancer, hepatoprotective, and antiviral properties.{48101} It inhibits the tyrosine kinases EGFR, pp50v-Src, and pp110gag-fes (IC50s = 6, 7-8, and 6.5 µg/ml, respectively) and decreases EGF-induced serine, threonine, and tyrosine phosphorylation of EGFR in A431 cells when used at a concentration of 20 µg/ml.{12005} Genistein inhibits proliferation and induces apoptosis in a variety of cancer cells, including Bel 7402 hepatocellular carcinoma cells when used at a concentration of 10 µg/ml.{48101,48102} It reduces tumor invasion and angiogenesis in a Bel 7402 mouse subrenal capsule xenograft model when administered at a dose of 50 mg/kg per day.{48102} However, when administered at the same dose on postnatal days 1-5, genistein increases the incidence of uterine adenocarcinoma in a mouse model of cancer induced by the estrogen receptor agonist diethylstilbestrol (DES; Item No. 10006876).{12017} It reduces lipid accumulation and inflammation in the liver of ovariectomized (OVX) and non-OVX female rats in a model of high-fat high-fructose diet-induced nonalcoholic hepatosteatosis (NASH) when administered at a dose of 16 mg/kg per day.{48103} Genistein (10 µM) also inhibits HIV-1 DNA synthesis in resting CD4+ T cells.{52875}
Brand:CaymanSKU:10005167 - 500 mgAvailable on backorder
Genistein-d4 is intended for use as an internal standard for the quantification of genistein (Item No. 10005167) by GC- or LC-MS. Genistein is an isoflavonoid phytoestrogen that has been found in soybeans (G. max/S. hispida) and has kinase inhibitory, anticancer, pro-cancer, hepatoprotective, and antiviral properties.{48101} It inhibits the tyrosine kinases EGFR, pp50v-Src, and pp110gag-fes (IC50 = 6, 7-8, and 6.5 µg/ml, respectively) and decreases EGF-induced serine, threonine, and tyrosine phosphorylation of EGFR in A431 cells when used at a concentration of 20 µg/ml.{12005} Genistein inhibits proliferation and induces apoptosis in a variety of cancer cells, including Bel 7402 hepatocellular carcinoma cells when used at a concentration of 10 µg/ml.{48101,48102} It reduces tumor invasion and angiogenesis in a Bel 7402 mouse subrenal capsule xenograft model when administered at a dose of 50 mg/kg per day.{48102} However, when administered at the same dose on postnatal days 1-5, genistein increases the incidence of uterine adenocarcinoma in a mouse model of cancer induced by the estrogen receptor agonist diethylstilbestrol (DES; Item No. 10006876).{12017} It reduces lipid accumulation and inflammation in the liver of ovariectomized (OVX) and non-OVX female rats in a model of high-fat high-fructose diet-induced nonalcoholic hepatosteatosis (NASH) when administered at a dose of 16 mg/kg per day.{48103} Genistein (10 µM) also inhibits HIV-1 DNA synthesis in resting CD4+ T cells.{52875}
Brand:CaymanSKU:-Available on backorder
Genistein-d4 is intended for use as an internal standard for the quantification of genistein (Item No. 10005167) by GC- or LC-MS. Genistein is an isoflavonoid phytoestrogen that has been found in soybeans (G. max/S. hispida) and has kinase inhibitory, anticancer, pro-cancer, hepatoprotective, and antiviral properties.{48101} It inhibits the tyrosine kinases EGFR, pp50v-Src, and pp110gag-fes (IC50 = 6, 7-8, and 6.5 µg/ml, respectively) and decreases EGF-induced serine, threonine, and tyrosine phosphorylation of EGFR in A431 cells when used at a concentration of 20 µg/ml.{12005} Genistein inhibits proliferation and induces apoptosis in a variety of cancer cells, including Bel 7402 hepatocellular carcinoma cells when used at a concentration of 10 µg/ml.{48101,48102} It reduces tumor invasion and angiogenesis in a Bel 7402 mouse subrenal capsule xenograft model when administered at a dose of 50 mg/kg per day.{48102} However, when administered at the same dose on postnatal days 1-5, genistein increases the incidence of uterine adenocarcinoma in a mouse model of cancer induced by the estrogen receptor agonist diethylstilbestrol (DES; Item No. 10006876).{12017} It reduces lipid accumulation and inflammation in the liver of ovariectomized (OVX) and non-OVX female rats in a model of high-fat high-fructose diet-induced nonalcoholic hepatosteatosis (NASH) when administered at a dose of 16 mg/kg per day.{48103} Genistein (10 µM) also inhibits HIV-1 DNA synthesis in resting CD4+ T cells.{52875}
Brand:CaymanSKU:-Available on backorder
Genistein-d4 is intended for use as an internal standard for the quantification of genistein (Item No. 10005167) by GC- or LC-MS. Genistein is an isoflavonoid phytoestrogen that has been found in soybeans (G. max/S. hispida) and has kinase inhibitory, anticancer, pro-cancer, hepatoprotective, and antiviral properties.{48101} It inhibits the tyrosine kinases EGFR, pp50v-Src, and pp110gag-fes (IC50 = 6, 7-8, and 6.5 µg/ml, respectively) and decreases EGF-induced serine, threonine, and tyrosine phosphorylation of EGFR in A431 cells when used at a concentration of 20 µg/ml.{12005} Genistein inhibits proliferation and induces apoptosis in a variety of cancer cells, including Bel 7402 hepatocellular carcinoma cells when used at a concentration of 10 µg/ml.{48101,48102} It reduces tumor invasion and angiogenesis in a Bel 7402 mouse subrenal capsule xenograft model when administered at a dose of 50 mg/kg per day.{48102} However, when administered at the same dose on postnatal days 1-5, genistein increases the incidence of uterine adenocarcinoma in a mouse model of cancer induced by the estrogen receptor agonist diethylstilbestrol (DES; Item No. 10006876).{12017} It reduces lipid accumulation and inflammation in the liver of ovariectomized (OVX) and non-OVX female rats in a model of high-fat high-fructose diet-induced nonalcoholic hepatosteatosis (NASH) when administered at a dose of 16 mg/kg per day.{48103} Genistein (10 µM) also inhibits HIV-1 DNA synthesis in resting CD4+ T cells.{52875}
Brand:CaymanSKU:-Available on backorder
Genistin is a natural isoflavone isolated from legumes, including soy and kudzu. It is a phytoestrogen, as it stimulates the growth of estrogen-dependent human breast cancer cells in vivo.{22651} Like other isoflavones, genistin promotes the proliferation of bone marrow stromal cells and osteoblasts and suppresses bone turnover.{22650,22649} It also increases bone formation in collagen matrix in vivo.{22652}
Brand:CaymanSKU:- Genistin is a natural isoflavone isolated from legumes, including soy and kudzu. It is a phytoestrogen, as it stimulates the growth of estrogen-dependent human breast cancer cells in vivo.{22651} Like other isoflavones, genistin promotes the proliferation of bone marrow stromal cells and osteoblasts and suppresses bone turnover.{22650,22649} It also increases bone formation in collagen matrix in vivo.{22652}
Brand:CaymanSKU:- Genistin is a natural isoflavone isolated from legumes, including soy and kudzu. It is a phytoestrogen, as it stimulates the growth of estrogen-dependent human breast cancer cells in vivo.{22651} Like other isoflavones, genistin promotes the proliferation of bone marrow stromal cells and osteoblasts and suppresses bone turnover.{22650,22649} It also increases bone formation in collagen matrix in vivo.{22652}
Brand:CaymanSKU:- Genistin is a natural isoflavone isolated from legumes, including soy and kudzu. It is a phytoestrogen, as it stimulates the growth of estrogen-dependent human breast cancer cells in vivo.{22651} Like other isoflavones, genistin promotes the proliferation of bone marrow stromal cells and osteoblasts and suppresses bone turnover.{22650,22649} It also increases bone formation in collagen matrix in vivo.{22652}
Brand:CaymanSKU:-
Gentiopicrin is an iridoid glycoside that has been found in G. rigescens and has diverse biological activities.{36986,36987,36988} In vivo, gentiopicrin (130 mg/kg) attenuates acute cholestasis and liver damage and reverses bile acid dyshomeostasis induced by α-napthylisothiocyanate (ANIT) in mice.{36986} It increases the paw withdrawal threshold in the cold-plate test and latency to paw withdrawal in the plantar test in mice when administered at doses of 25, 50, and 100 mg/kg.{36987} Gentiopicrin (100 mg/kg) also decreases NMDA receptor-mediated excitatory postsynaptic currents (EPSCs) in the nucleus accumbens and reverses morphine-induced conditioned place preference in mice.{36988}
Brand:CaymanSKU:25102 - 10 mgAvailable on backorder
Gentiopicrin is an iridoid glycoside that has been found in G. rigescens and has diverse biological activities.{36986,36987,36988} In vivo, gentiopicrin (130 mg/kg) attenuates acute cholestasis and liver damage and reverses bile acid dyshomeostasis induced by α-napthylisothiocyanate (ANIT) in mice.{36986} It increases the paw withdrawal threshold in the cold-plate test and latency to paw withdrawal in the plantar test in mice when administered at doses of 25, 50, and 100 mg/kg.{36987} Gentiopicrin (100 mg/kg) also decreases NMDA receptor-mediated excitatory postsynaptic currents (EPSCs) in the nucleus accumbens and reverses morphine-induced conditioned place preference in mice.{36988}
Brand:CaymanSKU:25102 - 100 mgAvailable on backorder
Gentiopicrin is an iridoid glycoside that has been found in G. rigescens and has diverse biological activities.{36986,36987,36988} In vivo, gentiopicrin (130 mg/kg) attenuates acute cholestasis and liver damage and reverses bile acid dyshomeostasis induced by α-napthylisothiocyanate (ANIT) in mice.{36986} It increases the paw withdrawal threshold in the cold-plate test and latency to paw withdrawal in the plantar test in mice when administered at doses of 25, 50, and 100 mg/kg.{36987} Gentiopicrin (100 mg/kg) also decreases NMDA receptor-mediated excitatory postsynaptic currents (EPSCs) in the nucleus accumbens and reverses morphine-induced conditioned place preference in mice.{36988}
Brand:CaymanSKU:25102 - 25 mgAvailable on backorder
Gentiopicrin is an iridoid glycoside that has been found in G. rigescens and has diverse biological activities.{36986,36987,36988} In vivo, gentiopicrin (130 mg/kg) attenuates acute cholestasis and liver damage and reverses bile acid dyshomeostasis induced by α-napthylisothiocyanate (ANIT) in mice.{36986} It increases the paw withdrawal threshold in the cold-plate test and latency to paw withdrawal in the plantar test in mice when administered at doses of 25, 50, and 100 mg/kg.{36987} Gentiopicrin (100 mg/kg) also decreases NMDA receptor-mediated excitatory postsynaptic currents (EPSCs) in the nucleus accumbens and reverses morphine-induced conditioned place preference in mice.{36988}
Brand:CaymanSKU:25102 - 50 mgAvailable on backorder
Gentisic acid is a benzoic acid that has been found in Gentiana and an active metabolite of aspirin (Item No. 70260) with diverse biological activities.{51131,51132,51133,51134,51135} It decreases radiation-induced production of thiobarbituric acid reactive substances (TBARS), hydrogen peroxide, and protein carbonyls, increases superoxide dismutase activity, and prevents hemolysis in isolated human erythrocytes when used at concentrations ranging from 5 to 100 μM.{51131} Gentisic acid (1-10 μM) inhibits LDL oxidation and formation of cholesterol ester hydroperoxides in isolated human plasma.{51132} It induces relaxation of isolated guinea pig trachea (EC50 = 20 μM), an effect that is reduced by the large-conductance calcium-activated potassium channel blocker charybdotoxin (Item No. 24115).{51133} Gentisic acid (10 and 100 mg/kg) reduces cardiac hypertrophy and fibrosis and pulmonary remodeling, suppresses the renin-angiotensin-aldosterone system, and inhibits cardiac dysfunction in a mouse model of transverse aortic constriction-induced cardiac hypertrophy.{51134} It also prevents cardiovascular collapse and lactic acidemia in a canine model of P. aeruginosa-induced septic shock.{51135}
Brand:CaymanSKU:27615 - 100 gAvailable on backorder
Gentisic acid is a benzoic acid that has been found in Gentiana and an active metabolite of aspirin (Item No. 70260) with diverse biological activities.{51131,51132,51133,51134,51135} It decreases radiation-induced production of thiobarbituric acid reactive substances (TBARS), hydrogen peroxide, and protein carbonyls, increases superoxide dismutase activity, and prevents hemolysis in isolated human erythrocytes when used at concentrations ranging from 5 to 100 μM.{51131} Gentisic acid (1-10 μM) inhibits LDL oxidation and formation of cholesterol ester hydroperoxides in isolated human plasma.{51132} It induces relaxation of isolated guinea pig trachea (EC50 = 20 μM), an effect that is reduced by the large-conductance calcium-activated potassium channel blocker charybdotoxin (Item No. 24115).{51133} Gentisic acid (10 and 100 mg/kg) reduces cardiac hypertrophy and fibrosis and pulmonary remodeling, suppresses the renin-angiotensin-aldosterone system, and inhibits cardiac dysfunction in a mouse model of transverse aortic constriction-induced cardiac hypertrophy.{51134} It also prevents cardiovascular collapse and lactic acidemia in a canine model of P. aeruginosa-induced septic shock.{51135}
Brand:CaymanSKU:27615 - 25 gAvailable on backorder
Gentisic acid is a benzoic acid that has been found in Gentiana and an active metabolite of aspirin (Item No. 70260) with diverse biological activities.{51131,51132,51133,51134,51135} It decreases radiation-induced production of thiobarbituric acid reactive substances (TBARS), hydrogen peroxide, and protein carbonyls, increases superoxide dismutase activity, and prevents hemolysis in isolated human erythrocytes when used at concentrations ranging from 5 to 100 μM.{51131} Gentisic acid (1-10 μM) inhibits LDL oxidation and formation of cholesterol ester hydroperoxides in isolated human plasma.{51132} It induces relaxation of isolated guinea pig trachea (EC50 = 20 μM), an effect that is reduced by the large-conductance calcium-activated potassium channel blocker charybdotoxin (Item No. 24115).{51133} Gentisic acid (10 and 100 mg/kg) reduces cardiac hypertrophy and fibrosis and pulmonary remodeling, suppresses the renin-angiotensin-aldosterone system, and inhibits cardiac dysfunction in a mouse model of transverse aortic constriction-induced cardiac hypertrophy.{51134} It also prevents cardiovascular collapse and lactic acidemia in a canine model of P. aeruginosa-induced septic shock.{51135}
Brand:CaymanSKU:27615 - 250 gAvailable on backorder
Gentisic acid is a benzoic acid that has been found in Gentiana and an active metabolite of aspirin (Item No. 70260) with diverse biological activities.{51131,51132,51133,51134,51135} It decreases radiation-induced production of thiobarbituric acid reactive substances (TBARS), hydrogen peroxide, and protein carbonyls, increases superoxide dismutase activity, and prevents hemolysis in isolated human erythrocytes when used at concentrations ranging from 5 to 100 μM.{51131} Gentisic acid (1-10 μM) inhibits LDL oxidation and formation of cholesterol ester hydroperoxides in isolated human plasma.{51132} It induces relaxation of isolated guinea pig trachea (EC50 = 20 μM), an effect that is reduced by the large-conductance calcium-activated potassium channel blocker charybdotoxin (Item No. 24115).{51133} Gentisic acid (10 and 100 mg/kg) reduces cardiac hypertrophy and fibrosis and pulmonary remodeling, suppresses the renin-angiotensin-aldosterone system, and inhibits cardiac dysfunction in a mouse model of transverse aortic constriction-induced cardiac hypertrophy.{51134} It also prevents cardiovascular collapse and lactic acidemia in a canine model of P. aeruginosa-induced septic shock.{51135}
Brand:CaymanSKU:27615 - 50 gAvailable on backorder
Genz-123346 is a glucosylceramide synthase inhibitor (IC50 = 14 nM).{46474} It reduces hepatic levels of glucosylceramide and triglycerides as well as blood levels of alanine aminotransferase (ALT), hemoglobin A1c, and non-fasting glucose in ob/ob mice when administered at a dose of 120 mg/kg per day.{46475} Genz-123346 (125 mg/kg per day) also decreases hepatic fat mass and reduces the size and number of hepatic lipid droplets in diet-induced obese mice.
Brand:CaymanSKU:28500 - 100 mgAvailable on backorder
Genz-123346 is a glucosylceramide synthase inhibitor (IC50 = 14 nM).{46474} It reduces hepatic levels of glucosylceramide and triglycerides as well as blood levels of alanine aminotransferase (ALT), hemoglobin A1c, and non-fasting glucose in ob/ob mice when administered at a dose of 120 mg/kg per day.{46475} Genz-123346 (125 mg/kg per day) also decreases hepatic fat mass and reduces the size and number of hepatic lipid droplets in diet-induced obese mice.
Brand:CaymanSKU:28500 - 50 mgAvailable on backorder
Genz-644282 is a topoisomerase I (TOP-I) inhibitor that inhibits TOP-I-mediated DNA cleavage 10-fold more potently than the TOP-I inhibitor topotecan (Item No. 14129).{41650} It inhibits the growth of and is cytotoxic to human and mouse bone marrow cells in a colony-forming unit assay (IC50s = 0.4 and 2.3 nM, respectively; IC90s = 1.2 and 8.4 nM, respectively).{41651} It also inhibits the growth of and is cytotoxic to human tumor cell lines (IC50s = 0.15-2 nM; IC90s = 0.7-8.3 nM). Genz-644282 inhibits tumor growth in mouse xenograft models when administered at doses ranging from 1.36 to 2.7 mg/kg.
Brand:CaymanSKU:24193 - 1 mgAvailable on backorder
Genz-644282 is a topoisomerase I (TOP-I) inhibitor that inhibits TOP-I-mediated DNA cleavage 10-fold more potently than the TOP-I inhibitor topotecan (Item No. 14129).{41650} It inhibits the growth of and is cytotoxic to human and mouse bone marrow cells in a colony-forming unit assay (IC50s = 0.4 and 2.3 nM, respectively; IC90s = 1.2 and 8.4 nM, respectively).{41651} It also inhibits the growth of and is cytotoxic to human tumor cell lines (IC50s = 0.15-2 nM; IC90s = 0.7-8.3 nM). Genz-644282 inhibits tumor growth in mouse xenograft models when administered at doses ranging from 1.36 to 2.7 mg/kg.
Brand:CaymanSKU:24193 - 10 mgAvailable on backorder