Cayman

Showing 20101–20250 of 45550 results

  • Estrone 3-methyl ether is a synthetic estrogen and derivative of estrone (Item No. 10006485).{51105} It stimulates proliferation of estrogen-dependent MCF-7 breast cancer cells in vitro when used at concentrations ranging from 0.16 to 20 μM but lacks estrogen receptor (ER) binding activity (IC50s = >100 μM for ERα and ERβ). Estrone 3-methyl ether has been used in the synthesis of various estrogen receptor modulators.{51106}  

     

    Brand:
    Cayman
    SKU:27978 - 10 g

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  • Estrone 3-methyl ether is a synthetic estrogen and derivative of estrone (Item No. 10006485).{51105} It stimulates proliferation of estrogen-dependent MCF-7 breast cancer cells in vitro when used at concentrations ranging from 0.16 to 20 μM but lacks estrogen receptor (ER) binding activity (IC50s = >100 μM for ERα and ERβ). Estrone 3-methyl ether has been used in the synthesis of various estrogen receptor modulators.{51106}  

     

    Brand:
    Cayman
    SKU:27978 - 5 g

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  • Estrone 3-methyl ether is a synthetic estrogen and derivative of estrone (Item No. 10006485).{51105} It stimulates proliferation of estrogen-dependent MCF-7 breast cancer cells in vitro when used at concentrations ranging from 0.16 to 20 μM but lacks estrogen receptor (ER) binding activity (IC50s = >100 μM for ERα and ERβ). Estrone 3-methyl ether has been used in the synthesis of various estrogen receptor modulators.{51106}  

     

    Brand:
    Cayman
    SKU:27978 - 500 mg

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  • Estrone 3-sulfate is an endogenous steroid and an estrogen ester that is biologically inactive. It is converted by steroid sulfatase into estrone (Item No. 10006485). Estrone 3-sulfate has been investigated as a ligand for targeting organic anion transporting polypeptides for the detection of hormone-dependent breast cancers.{32192}  

     

    Brand:
    Cayman
    SKU:20513 -

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  • Estrone 3-sulfate is an endogenous steroid and an estrogen ester that is biologically inactive. It is converted by steroid sulfatase into estrone (Item No. 10006485). Estrone 3-sulfate has been investigated as a ligand for targeting organic anion transporting polypeptides for the detection of hormone-dependent breast cancers.{32192}  

     

    Brand:
    Cayman
    SKU:20513 -

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  • Estrone 3-sulfate is an endogenous steroid and an estrogen ester that is biologically inactive. It is converted by steroid sulfatase into estrone (Item No. 10006485). Estrone 3-sulfate has been investigated as a ligand for targeting organic anion transporting polypeptides for the detection of hormone-dependent breast cancers.{32192}  

     

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    Cayman
    SKU:20513 -

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  • Estrone-3-glucuronide is the predominant metabolite of estradiol in urine and a urinary marker for the fertile window in women.{40240} Measurement of urinary glucuronides is a convenient, non-invasive method for detecting reproductive hormone levels compared to measuring plasma levels.{40241} Estrone-3-glucuronide, along with pregnanediol-3-glucuronide, are indicators of female reproductive health.{40241} Literature has shown high serum estrone levels, which directly correlate to urinary estrone-3-glucuronide levels, are associated with estrogen receptor-positive breast cancers.{40244} Hormone receptor status is the main factor in planning treatment and can be treated with hormone therapies, including tamoxifen and aromatase inhibitors.{40247} In addition to its role in breast cancer, circulating estrogens, including estrone metabolized from oral hormone replacement therapy, have been shown to increase thrombin generation leading to higher risk for blood clots, myocardial infarctions, deep vein thrombosis and strokes.{40245,40246}  

     

    Brand:
    Cayman
    SKU:501290 - 96 solid plate

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  • Estrone-3-glucuronide is the predominant metabolite of estradiol in urine and a urinary marker for the fertile window in women.{40240} Measurement of urinary glucuronides is a convenient, non-invasive method for detecting reproductive hormone levels compared to measuring plasma levels.{40241} Estrone-3-glucuronide, along with pregnanediol-3-glucuronide, are indicators of female reproductive health.{40241} Literature has shown high serum estrone levels, which directly correlate to urinary estrone-3-glucuronide levels, are associated with estrogen receptor-positive breast cancers.{40244} Hormone receptor status is the main factor in planning treatment and can be treated with hormone therapies, including tamoxifen and aromatase inhibitors.{40247} In addition to its role in breast cancer, circulating estrogens, including estrone metabolized from oral hormone replacement therapy, have been shown to increase thrombin generation leading to higher risk for blood clots, myocardial infarctions, deep vein thrombosis and strokes.{40245,40246}  

     

    Brand:
    Cayman
    SKU:501290 - 96 strip plate

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  • Estrone-d2 is intended for use as an internal standard for the quantification of estrone (Item Nos. ISO60165 | 10006485) by GC- or LC-MS. Estrone is one of the three naturally occurring estrogens, the others being estradiol (Item Nos. ISO60155 | 10006315) and estriol (Item Nos. ISO60164 | 10006484).{9611} Estrone is synthesized from androstenedione (Item No. ISO60161) by the aromatase enzyme system in the ovaries and placenta, and is also synthesized from estradiol by 17-hydroxy steroid dehydrogenase in the liver.{9611,8343} Serum concentrations of estrone in premenopausal women fluctuate according to the menstrual cycle and becomes the most predominant estrogen in postmenopausal women.{9611} The binding affinities of estrone to the estrogen receptors α and β are approximately 60% and 37% relative to estradiol.{9611}  

     

    Brand:
    Cayman
    SKU:9002844 - 1 mg

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  • Estrone-d2 is intended for use as an internal standard for the quantification of estrone (Item Nos. ISO60165 | 10006485) by GC- or LC-MS. Estrone is one of the three naturally occurring estrogens, the others being estradiol (Item Nos. ISO60155 | 10006315) and estriol (Item Nos. ISO60164 | 10006484).{9611} Estrone is synthesized from androstenedione (Item No. ISO60161) by the aromatase enzyme system in the ovaries and placenta, and is also synthesized from estradiol by 17-hydroxy steroid dehydrogenase in the liver.{9611,8343} Serum concentrations of estrone in premenopausal women fluctuate according to the menstrual cycle and becomes the most predominant estrogen in postmenopausal women.{9611} The binding affinities of estrone to the estrogen receptors α and β are approximately 60% and 37% relative to estradiol.{9611}  

     

    Brand:
    Cayman
    SKU:9002844 - 500 µg

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  • Estropipate is a piperazine salt form of estrone 3-sulfate (Item No. 20513), which is an inactive endogenous steroid that is converted into estrone (Item No. 10006485) in vivo.{32192} Estropipate is also an inhibitor of organic anion transport polypeptide 1B1 (OATP1B1) that is selective for OAT1B1 over OAT1B3 (IC50s = 0.06 and 19.3 µM, respectively).{41286} Formulations containing estropipate have been used in the treatment of menopausal symptoms and for the prevention of osteoporosis in high risk populations.  

     

    Brand:
    Cayman
    SKU:23806 - 10 mg

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  • Estropipate is a piperazine salt form of estrone 3-sulfate (Item No. 20513), which is an inactive endogenous steroid that is converted into estrone (Item No. 10006485) in vivo.{32192} Estropipate is also an inhibitor of organic anion transport polypeptide 1B1 (OATP1B1) that is selective for OAT1B1 over OAT1B3 (IC50s = 0.06 and 19.3 µM, respectively).{41286} Formulations containing estropipate have been used in the treatment of menopausal symptoms and for the prevention of osteoporosis in high risk populations.  

     

    Brand:
    Cayman
    SKU:23806 - 5 mg

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  • Etaqualone (Item No. 11152) is an analytical reference standard categorized as a quinazolone.{41356} This product is intended for research and forensic applications.  

     

    Brand:
    Cayman
    SKU:11152 - 1 mg

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  • Etaqualone (Item No. 11152) is an analytical reference standard categorized as a quinazolone.{41356} This product is intended for research and forensic applications.  

     

    Brand:
    Cayman
    SKU:11152 - 10 mg

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  • Etaqualone (Item No. 11152) is an analytical reference standard categorized as a quinazolone.{41356} This product is intended for research and forensic applications.  

     

    Brand:
    Cayman
    SKU:11152 - 5 mg

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  • ETC-1002 is a prodrug form of ETC-1002-CoA.{46141} ETC-1002 is conjugated to coenzyme A (CoA) by very long-chain acyl-CoA synthetase-1 (ACSVL1) to form ETC-1002-CoA, which inhibits ATP citrate lyase (Ki = 2 μM) and activates AMP-activated protein kinase (AMPK). ETC-1002 suppresses total lipid synthesis in wild-type and AMPKβ1 knockout primary murine hepatocytes. In vivo, ETC-1002 (30 mg/kg) prevents increases in hepatic cholesterol and reduces the size of aortic atherosclerotic lesions induced by a high-fat high-cholesterol diet in Apoe-/-/Ampkβ1-/- (DKO) mice.  

     

    Brand:
    Cayman
    SKU:26409 - 10 mg

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  • ETC-1002 is a prodrug form of ETC-1002-CoA.{46141} ETC-1002 is conjugated to coenzyme A (CoA) by very long-chain acyl-CoA synthetase-1 (ACSVL1) to form ETC-1002-CoA, which inhibits ATP citrate lyase (Ki = 2 μM) and activates AMP-activated protein kinase (AMPK). ETC-1002 suppresses total lipid synthesis in wild-type and AMPKβ1 knockout primary murine hepatocytes. In vivo, ETC-1002 (30 mg/kg) prevents increases in hepatic cholesterol and reduces the size of aortic atherosclerotic lesions induced by a high-fat high-cholesterol diet in Apoe-/-/Ampkβ1-/- (DKO) mice.  

     

    Brand:
    Cayman
    SKU:26409 - 25 mg

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  • ETC-1002 is a prodrug form of ETC-1002-CoA.{46141} ETC-1002 is conjugated to coenzyme A (CoA) by very long-chain acyl-CoA synthetase-1 (ACSVL1) to form ETC-1002-CoA, which inhibits ATP citrate lyase (Ki = 2 μM) and activates AMP-activated protein kinase (AMPK). ETC-1002 suppresses total lipid synthesis in wild-type and AMPKβ1 knockout primary murine hepatocytes. In vivo, ETC-1002 (30 mg/kg) prevents increases in hepatic cholesterol and reduces the size of aortic atherosclerotic lesions induced by a high-fat high-cholesterol diet in Apoe-/-/Ampkβ1-/- (DKO) mice.  

     

    Brand:
    Cayman
    SKU:26409 - 5 mg

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  • ETC-1002 is a prodrug form of ETC-1002-CoA.{46141} ETC-1002 is conjugated to coenzyme A (CoA) by very long-chain acyl-CoA synthetase-1 (ACSVL1) to form ETC-1002-CoA, which inhibits ATP citrate lyase (Ki = 2 μM) and activates AMP-activated protein kinase (AMPK). ETC-1002 suppresses total lipid synthesis in wild-type and AMPKβ1 knockout primary murine hepatocytes. In vivo, ETC-1002 (30 mg/kg) prevents increases in hepatic cholesterol and reduces the size of aortic atherosclerotic lesions induced by a high-fat high-cholesterol diet in Apoe-/-/Ampkβ1-/- (DKO) mice.  

     

    Brand:
    Cayman
    SKU:26409 - 50 mg

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  • ETC-159 is a potent and orally bioavailable inhibitor of porcupine (PORCN; IC50s = 18.1 and 70 nM for mouse and Xenopus PORCN, respectively).{38876} It inhibits β-catenin reporter activity (IC50 = 2.9 nM) and reduces the interaction of Wnt with its carrier protein WLS via decreased Wnt palmitoleation in STF3A cells, an effect that is reversed by overexpression of recombinant PORCN. ETC-159 inhibits PA-1 teratocarcinoma colony formation in soft agar (IC50 = 35 nM). In vivo, ETC-159 (1-10 mg/kg) reduces tumor growth in a dose-dependent manner in mice carrying a mouse mammary tumor virus LTR-Wnt1 transgene and in A-1 and NCCIT teratocarcinoma mouse xenograft models. It also reduces growth and induces differentiation in colon adenocarcinoma mouse xenograft models that contain R-spondin (RSPO) translocations.  

     

    Brand:
    Cayman
    SKU:24104 - 1 mg

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  • ETC-159 is a potent and orally bioavailable inhibitor of porcupine (PORCN; IC50s = 18.1 and 70 nM for mouse and Xenopus PORCN, respectively).{38876} It inhibits β-catenin reporter activity (IC50 = 2.9 nM) and reduces the interaction of Wnt with its carrier protein WLS via decreased Wnt palmitoleation in STF3A cells, an effect that is reversed by overexpression of recombinant PORCN. ETC-159 inhibits PA-1 teratocarcinoma colony formation in soft agar (IC50 = 35 nM). In vivo, ETC-159 (1-10 mg/kg) reduces tumor growth in a dose-dependent manner in mice carrying a mouse mammary tumor virus LTR-Wnt1 transgene and in A-1 and NCCIT teratocarcinoma mouse xenograft models. It also reduces growth and induces differentiation in colon adenocarcinoma mouse xenograft models that contain R-spondin (RSPO) translocations.  

     

    Brand:
    Cayman
    SKU:24104 - 10 mg

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  • ETC-159 is a potent and orally bioavailable inhibitor of porcupine (PORCN; IC50s = 18.1 and 70 nM for mouse and Xenopus PORCN, respectively).{38876} It inhibits β-catenin reporter activity (IC50 = 2.9 nM) and reduces the interaction of Wnt with its carrier protein WLS via decreased Wnt palmitoleation in STF3A cells, an effect that is reversed by overexpression of recombinant PORCN. ETC-159 inhibits PA-1 teratocarcinoma colony formation in soft agar (IC50 = 35 nM). In vivo, ETC-159 (1-10 mg/kg) reduces tumor growth in a dose-dependent manner in mice carrying a mouse mammary tumor virus LTR-Wnt1 transgene and in A-1 and NCCIT teratocarcinoma mouse xenograft models. It also reduces growth and induces differentiation in colon adenocarcinoma mouse xenograft models that contain R-spondin (RSPO) translocations.  

     

    Brand:
    Cayman
    SKU:24104 - 25 mg

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  • ETC-159 is a potent and orally bioavailable inhibitor of porcupine (PORCN; IC50s = 18.1 and 70 nM for mouse and Xenopus PORCN, respectively).{38876} It inhibits β-catenin reporter activity (IC50 = 2.9 nM) and reduces the interaction of Wnt with its carrier protein WLS via decreased Wnt palmitoleation in STF3A cells, an effect that is reversed by overexpression of recombinant PORCN. ETC-159 inhibits PA-1 teratocarcinoma colony formation in soft agar (IC50 = 35 nM). In vivo, ETC-159 (1-10 mg/kg) reduces tumor growth in a dose-dependent manner in mice carrying a mouse mammary tumor virus LTR-Wnt1 transgene and in A-1 and NCCIT teratocarcinoma mouse xenograft models. It also reduces growth and induces differentiation in colon adenocarcinoma mouse xenograft models that contain R-spondin (RSPO) translocations.  

     

    Brand:
    Cayman
    SKU:24104 - 5 mg

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  • Etelcalcetide is a peptide agonist of the calcium-sensing receptor (CaSR).{47345} It is selective for CaSR over a panel of 33 receptors and ion channels, as well as the norepinephrine transporter at 10 µM. Etelcalcetide increases intracellular calcium levels in HEK293T cells expressing the human CaSR receptor with an EC50 value of 0.53 µM. It also inhibits parathyroid secretion from primary rat parathyroid cells (EC50 = 0.36 µM in the presence of calcium). Etelcalcetide (0.3, 1, and 3 mg/kg) decreases parathyroid hormone and calcium levels in plasma and serum, respectively, in a model of chronic renal insufficiency with secondary hyperthyroidism in nephrectomized rats fed a high-phosphorus diet. Formulations containing etelcalcetide have been used in the treatment of secondary hyperparathyroidism in adult patients with chronic kidney disease undergoing hemodialysis.  

     

    Brand:
    Cayman
    SKU:26901 - 1 mg

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  • Etelcalcetide is a peptide agonist of the calcium-sensing receptor (CaSR).{47345} It is selective for CaSR over a panel of 33 receptors and ion channels, as well as the norepinephrine transporter at 10 µM. Etelcalcetide increases intracellular calcium levels in HEK293T cells expressing the human CaSR receptor with an EC50 value of 0.53 µM. It also inhibits parathyroid secretion from primary rat parathyroid cells (EC50 = 0.36 µM in the presence of calcium). Etelcalcetide (0.3, 1, and 3 mg/kg) decreases parathyroid hormone and calcium levels in plasma and serum, respectively, in a model of chronic renal insufficiency with secondary hyperthyroidism in nephrectomized rats fed a high-phosphorus diet. Formulations containing etelcalcetide have been used in the treatment of secondary hyperparathyroidism in adult patients with chronic kidney disease undergoing hemodialysis.  

     

    Brand:
    Cayman
    SKU:26901 - 10 mg

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  • Etelcalcetide is a peptide agonist of the calcium-sensing receptor (CaSR).{47345} It is selective for CaSR over a panel of 33 receptors and ion channels, as well as the norepinephrine transporter at 10 µM. Etelcalcetide increases intracellular calcium levels in HEK293T cells expressing the human CaSR receptor with an EC50 value of 0.53 µM. It also inhibits parathyroid secretion from primary rat parathyroid cells (EC50 = 0.36 µM in the presence of calcium). Etelcalcetide (0.3, 1, and 3 mg/kg) decreases parathyroid hormone and calcium levels in plasma and serum, respectively, in a model of chronic renal insufficiency with secondary hyperthyroidism in nephrectomized rats fed a high-phosphorus diet. Formulations containing etelcalcetide have been used in the treatment of secondary hyperparathyroidism in adult patients with chronic kidney disease undergoing hemodialysis.  

     

    Brand:
    Cayman
    SKU:26901 - 5 mg

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  • Ethacrynic acid is a loop diuretic with anticancer activity.{53194},{33064,33063} It inhibits the Na-K-2Cl (NKCC) cotransporter in duck erythrocytes (IC50 = 0.18 mM) and ATP-dependent chloride uptake in rat renal plasma membrane vesicles when used at a concentration of 0.3 mM.{53194},{33062} Ethacrynic acid also inhibits glutathione S-transferase P1-1 (GSTP1-1) and GSTA3-3 (IC50s = 4.9 and ~0.4 μM, respectively), and inhibits Wnt/β-catenin signaling in a cell-based reporter assay.{41510,33064} It is cytotoxic to primary chronic lymphocytic leukemia cells (IC50 = 8.56 μM), as well as MCF-7, MDA-MB-231, and 4T1 cancer cells (IC50s = 45.53, 39.64, and 25.23 μM, respectively).{33064,33063} Ethacrynic acid (250 μg per day) increases tumor growth reduction induced by the EGFR family inhibitors afatinib (Item Nos. 11492 | 21567) or neratinib (Item No. 18404) in a 4T1 murine breast cancer model.{33063} Formulations containing ethacrynic acid have been used in the treatment of edema.  

     

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    Cayman
    SKU:-

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  • Ethacrynic acid is a loop diuretic with anticancer activity.{53194},{33064,33063} It inhibits the Na-K-2Cl (NKCC) cotransporter in duck erythrocytes (IC50 = 0.18 mM) and ATP-dependent chloride uptake in rat renal plasma membrane vesicles when used at a concentration of 0.3 mM.{53194},{33062} Ethacrynic acid also inhibits glutathione S-transferase P1-1 (GSTP1-1) and GSTA3-3 (IC50s = 4.9 and ~0.4 μM, respectively), and inhibits Wnt/β-catenin signaling in a cell-based reporter assay.{41510,33064} It is cytotoxic to primary chronic lymphocytic leukemia cells (IC50 = 8.56 μM), as well as MCF-7, MDA-MB-231, and 4T1 cancer cells (IC50s = 45.53, 39.64, and 25.23 μM, respectively).{33064,33063} Ethacrynic acid (250 μg per day) increases tumor growth reduction induced by the EGFR family inhibitors afatinib (Item Nos. 11492 | 21567) or neratinib (Item No. 18404) in a 4T1 murine breast cancer model.{33063} Formulations containing ethacrynic acid have been used in the treatment of edema.  

     

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    Cayman
    SKU:-

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  • Ethacrynic acid (Item No. 26299) is an analytical reference standard categorized as a loop diuretic.{33062} Diuretics, including ethacrynic acid, have been used as masking agents in sports doping, including racehorse doping.{48475,46368} This product is intended for use in analytical forensic applications. This product is also available as a general research tool (Item No. 19536).  

     

    Brand:
    Cayman
    SKU:26299 - 10 mg

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  • Ethacrynic acid is a loop diuretic with anticancer activity.{53194},{33064,33063} It inhibits the Na-K-2Cl (NKCC) cotransporter in duck erythrocytes (IC50 = 0.18 mM) and ATP-dependent chloride uptake in rat renal plasma membrane vesicles when used at a concentration of 0.3 mM.{53194},{33062} Ethacrynic acid also inhibits glutathione S-transferase P1-1 (GSTP1-1) and GSTA3-3 (IC50s = 4.9 and ~0.4 μM, respectively), and inhibits Wnt/β-catenin signaling in a cell-based reporter assay.{41510,33064} It is cytotoxic to primary chronic lymphocytic leukemia cells (IC50 = 8.56 μM), as well as MCF-7, MDA-MB-231, and 4T1 cancer cells (IC50s = 45.53, 39.64, and 25.23 μM, respectively).{33064,33063} Ethacrynic acid (250 μg per day) increases tumor growth reduction induced by the EGFR family inhibitors afatinib (Item Nos. 11492 | 21567) or neratinib (Item No. 18404) in a 4T1 murine breast cancer model.{33063} Formulations containing ethacrynic acid have been used in the treatment of edema.  

     

    Brand:
    Cayman
    SKU:-

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  • Ethacrynic acid (Item No. 26299) is an analytical reference standard categorized as a loop diuretic.{33062} Diuretics, including ethacrynic acid, have been used as masking agents in sports doping, including racehorse doping.{48475,46368} This product is intended for use in analytical forensic applications. This product is also available as a general research tool (Item No. 19536).  

     

    Brand:
    Cayman
    SKU:26299 - 50 mg

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  • Ethacrynic acid-d5 is intended for use as an internal standard for the quantification of ethacrynic acid (Item No. 19536) by GC- or LC-MS. Ethacrynic acid is a loop diuretic with anticancer activity.{53194,33064,33063} It inhibits the Na-K-2Cl (NKCC) cotransporter in duck erythrocytes (IC50 = 0.18 mM) and ATP-dependent chloride uptake in rat renal plasma membrane vesicles when used at a concentration of 0.3 mM.{53194,33062} Ethacrynic acid also inhibits glutathione S-transferase P1-1 (GSTP1-1) and GSTA3-3 (IC50s = 4.9 and ~0.4 μM, respectively), and inhibits Wnt/β-catenin signaling in a cell-based reporter assay.{33064,41510} It is cytotoxic to primary chronic lymphocytic leukemia cells (IC50 = 8.56 μM), as well as MCF-7, MDA-MB-231, and 4T1 cancer cells (IC50s = 45.53, 39.64, and 25.23 μM, respectively).{33064,33063} Ethacrynic acid (250 μg per day) increases tumor growth reduction induced by the EGFR family inhibitors afatinib (Item Nos. 11492 | 21567 ) or neratinib (Item No. 18404) in a 4T1 murine breast cancer model.{33063} Formulations containing ethacrynic acid have been used in the treatment of edema.  

     

    Brand:
    Cayman
    SKU:28537 - 2 mg

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  • Ethambutol is an antimycobacterial compound that inhibits the growth of M. tuberculosis in vitro at a concentration of 10 μg/ml.{40409} It is protective against M. smegmatis infections in rhesus monkeys (50, 30, and 0% fatalities at doses of 12.5, 25, and 50 mg/kg, respectively) and clears M. smegmatis pulmonary infiltrates at a dose of 100 mg/kg.{40410} Formulations containing ethambutol have been used in the treatment of tuberculosis.  

     

    Brand:
    Cayman
    SKU:23713 - 1 g

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  • Ethambutol is an antimycobacterial compound that inhibits the growth of M. tuberculosis in vitro at a concentration of 10 μg/ml.{40409} It is protective against M. smegmatis infections in rhesus monkeys (50, 30, and 0% fatalities at doses of 12.5, 25, and 50 mg/kg, respectively) and clears M. smegmatis pulmonary infiltrates at a dose of 100 mg/kg.{40410} Formulations containing ethambutol have been used in the treatment of tuberculosis.  

     

    Brand:
    Cayman
    SKU:23713 - 10 g

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  • Ethambutol is an antimycobacterial compound that inhibits the growth of M. tuberculosis in vitro at a concentration of 10 μg/ml.{40409} It is protective against M. smegmatis infections in rhesus monkeys (50, 30, and 0% fatalities at doses of 12.5, 25, and 50 mg/kg, respectively) and clears M. smegmatis pulmonary infiltrates at a dose of 100 mg/kg.{40410} Formulations containing ethambutol have been used in the treatment of tuberculosis.  

     

    Brand:
    Cayman
    SKU:23713 - 5 g

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  • Ethamivan is a phenol that has been found in M. esculenta and has antioxidant and analeptic properties.{53792,53793,53794} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) and ABTS (Item No. 27317) radicals with EC50 values of 0.374 and 0.05 mg/ml, respectively, in cell-free assays.{53792} Ethamivan (0.25 mg/kg, i.v.) increases the respiratory rate of anesthetized cats, an effect that can be blocked by cervical vagotomy.{53793} Intravenous infusion of ethamivan (19.4-25.2 mg/kg) induces convulsions in conscious cats.{53794}  

     

    Brand:
    Cayman
    SKU:30876 - 1 g

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  • Ethamivan is a phenol that has been found in M. esculenta and has antioxidant and analeptic properties.{53792,53793,53794} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) and ABTS (Item No. 27317) radicals with EC50 values of 0.374 and 0.05 mg/ml, respectively, in cell-free assays.{53792} Ethamivan (0.25 mg/kg, i.v.) increases the respiratory rate of anesthetized cats, an effect that can be blocked by cervical vagotomy.{53793} Intravenous infusion of ethamivan (19.4-25.2 mg/kg) induces convulsions in conscious cats.{53794}  

     

    Brand:
    Cayman
    SKU:30876 - 250 mg

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  • Ethamivan is a phenol that has been found in M. esculenta and has antioxidant and analeptic properties.{53792,53793,53794} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) and ABTS (Item No. 27317) radicals with EC50 values of 0.374 and 0.05 mg/ml, respectively, in cell-free assays.{53792} Ethamivan (0.25 mg/kg, i.v.) increases the respiratory rate of anesthetized cats, an effect that can be blocked by cervical vagotomy.{53793} Intravenous infusion of ethamivan (19.4-25.2 mg/kg) induces convulsions in conscious cats.{53794}  

     

    Brand:
    Cayman
    SKU:30876 - 500 mg

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  • Brand:
    Cayman
    SKU:700566 - 2 ml

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  • Etherolenic acid is a divinyl ether oxylipin.{1809,57108} It is a metabolite of linolenic acid that is formed in plants via 13-lipoxygenase-mediated formation of 13(S)-HpOTrE (Item No. 45220) followed by conversion to the divinyl ether by divinyl ether synthase.  

     

    Brand:
    Cayman
    SKU:10005123 - 150 µg

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  • Etherolenic acid is a divinyl ether oxylipin.{1809,57108} It is a metabolite of linolenic acid that is formed in plants via 13-lipoxygenase-mediated formation of 13(S)-HpOTrE (Item No. 45220) followed by conversion to the divinyl ether by divinyl ether synthase.  

     

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    Cayman
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  • Ethionamide is an antimycobacterial compound that is active against M. tuberculosis (MICs = 0.3-1.25 µg/ml).{41216,41215} It is activated via oxidation by flavin monooxygenase and inhibits the InhA enzyme involved in mycolic acid biosynthesis.{41216} Formulations containing ethionamide have been used in the second-line treatment of multi-drug resistant tuberculosis.  

     

    Brand:
    Cayman
    SKU:23714 - 1 g

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  • Ethionamide is an antimycobacterial compound that is active against M. tuberculosis (MICs = 0.3-1.25 µg/ml).{41216,41215} It is activated via oxidation by flavin monooxygenase and inhibits the InhA enzyme involved in mycolic acid biosynthesis.{41216} Formulations containing ethionamide have been used in the second-line treatment of multi-drug resistant tuberculosis.  

     

    Brand:
    Cayman
    SKU:23714 - 10 g

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  • Ethionamide is an antimycobacterial compound that is active against M. tuberculosis (MICs = 0.3-1.25 µg/ml).{41216,41215} It is activated via oxidation by flavin monooxygenase and inhibits the InhA enzyme involved in mycolic acid biosynthesis.{41216} Formulations containing ethionamide have been used in the second-line treatment of multi-drug resistant tuberculosis.  

     

    Brand:
    Cayman
    SKU:23714 - 5 g

    Available on backorder

  • Ethisterone is an orally bioavailable synthetic progestin and a derivative of testosterone (Item Nos. ISO60154 | 15645) that binds to progesterone and androgen receptors (EC50s = 23 and 23.1 nM, respectively, in yeast).{40099} Ethisterone (1 µM) downregulates progesterone receptors in MCF-7 cells.{40098}  

     

    Brand:
    Cayman
    SKU:22893 - 1 g

    Available on backorder

  • Ethisterone is an orally bioavailable synthetic progestin and a derivative of testosterone (Item Nos. ISO60154 | 15645) that binds to progesterone and androgen receptors (EC50s = 23 and 23.1 nM, respectively, in yeast).{40099} Ethisterone (1 µM) downregulates progesterone receptors in MCF-7 cells.{40098}  

     

    Brand:
    Cayman
    SKU:22893 - 10 g

    Available on backorder

  • Ethisterone is an orally bioavailable synthetic progestin and a derivative of testosterone (Item Nos. ISO60154 | 15645) that binds to progesterone and androgen receptors (EC50s = 23 and 23.1 nM, respectively, in yeast).{40099} Ethisterone (1 µM) downregulates progesterone receptors in MCF-7 cells.{40098}  

     

    Brand:
    Cayman
    SKU:22893 - 25 g

    Available on backorder

  • Ethisterone is an orally bioavailable synthetic progestin and a derivative of testosterone (Item Nos. ISO60154 | 15645) that binds to progesterone and androgen receptors (EC50s = 23 and 23.1 nM, respectively, in yeast).{40099} Ethisterone (1 µM) downregulates progesterone receptors in MCF-7 cells.{40098}  

     

    Brand:
    Cayman
    SKU:22893 - 5 g

    Available on backorder

  • Ethoprop is an organothiophosphate nematicide and insecticide.{48845,48846,48847} It decreases the infectivity of M. chitwoodi and M. hapla second-stage juveniles (EC50s = 5.6 and 6.8 μg/ml, respectively) and inhibits hatching of M. chitwoodi egg masses and M. chitwoodi and M. hapla free eggs (EC50s = 0.2, 46, and 83.3 μg/ml, respectively).{48846} Ethoprop (1.8 μg/g) decreases the number of M. chitwoodi nematodes in tomato roots when added to soil from fields without previous ethoprop exposure, but is biodegraded in soil from fields previously exposed to ethoprop. In field trials, it decreases the percentage of potato tubers damaged by wireworms when applied as granules in the planting furrow at a concentration of 3 kg AI/ha.{48847} Ethoprop is toxic to rats via oral administration and dermal contact (LD50s = 47 and 226 mg/kg, respectively) as well as inhalation (LD50 = 0.123 mg/L).{48845} It is also toxic to bluegill (LC50 = 0.32 mg/L). Formulations containing ethoprop have been used in the agricultural control of pests.  

     

    Brand:
    Cayman
    SKU:27609 - 100 mg

    Available on backorder

  • Ethoprop is an organothiophosphate nematicide and insecticide.{48845,48846,48847} It decreases the infectivity of M. chitwoodi and M. hapla second-stage juveniles (EC50s = 5.6 and 6.8 μg/ml, respectively) and inhibits hatching of M. chitwoodi egg masses and M. chitwoodi and M. hapla free eggs (EC50s = 0.2, 46, and 83.3 μg/ml, respectively).{48846} Ethoprop (1.8 μg/g) decreases the number of M. chitwoodi nematodes in tomato roots when added to soil from fields without previous ethoprop exposure, but is biodegraded in soil from fields previously exposed to ethoprop. In field trials, it decreases the percentage of potato tubers damaged by wireworms when applied as granules in the planting furrow at a concentration of 3 kg AI/ha.{48847} Ethoprop is toxic to rats via oral administration and dermal contact (LD50s = 47 and 226 mg/kg, respectively) as well as inhalation (LD50 = 0.123 mg/L).{48845} It is also toxic to bluegill (LC50 = 0.32 mg/L). Formulations containing ethoprop have been used in the agricultural control of pests.  

     

    Brand:
    Cayman
    SKU:27609 - 50 mg

    Available on backorder

  • Ethopropazine is a butyrylcholinesterase (BChE) inhibitor (IC50 = 15.14 µM in human erythrocyte lysates).{53481} It is selective for BChE over acetylcholinesterase (AChE) at 500 µM. Ethopropazine also binds to rat forebrain and hindbrain membrane preparations (Kis = 3.1 and 7.2 nM, respectively), which are endogenously enriched in M1 and M2 muscarinic acetylcholine receptors, respectively.{53482} Ethopropazine (0.232 mg/kg) decreases the intensity and increases the latency of haloperidol-induced catalepsy, a model of extrapyramidal syndrome, in rats when used in combination with the adenosine A2A receptor antagonist ZM 241395 (Item No. 20447).{53483} It reduces thermal hyperalgesia in a rat model of neuropathic pain induced by sciatic nerve ligation when administered at doses of 20 and 30 mg/kg.{53484} Formulations containing ethopropazine were previously used in the treatment of Parkinson’s disease.  

     

    Brand:
    Cayman
    SKU:28493 - 10 mg

    Available on backorder

  • Ethopropazine is a butyrylcholinesterase (BChE) inhibitor (IC50 = 15.14 µM in human erythrocyte lysates).{53481} It is selective for BChE over acetylcholinesterase (AChE) at 500 µM. Ethopropazine also binds to rat forebrain and hindbrain membrane preparations (Kis = 3.1 and 7.2 nM, respectively), which are endogenously enriched in M1 and M2 muscarinic acetylcholine receptors, respectively.{53482} Ethopropazine (0.232 mg/kg) decreases the intensity and increases the latency of haloperidol-induced catalepsy, a model of extrapyramidal syndrome, in rats when used in combination with the adenosine A2A receptor antagonist ZM 241395 (Item No. 20447).{53483} It reduces thermal hyperalgesia in a rat model of neuropathic pain induced by sciatic nerve ligation when administered at doses of 20 and 30 mg/kg.{53484} Formulations containing ethopropazine were previously used in the treatment of Parkinson’s disease.  

     

    Brand:
    Cayman
    SKU:28493 - 100 mg

    Available on backorder

  • Ethopropazine is a butyrylcholinesterase (BChE) inhibitor (IC50 = 15.14 µM in human erythrocyte lysates).{53481} It is selective for BChE over acetylcholinesterase (AChE) at 500 µM. Ethopropazine also binds to rat forebrain and hindbrain membrane preparations (Kis = 3.1 and 7.2 nM, respectively), which are endogenously enriched in M1 and M2 muscarinic acetylcholine receptors, respectively.{53482} Ethopropazine (0.232 mg/kg) decreases the intensity and increases the latency of haloperidol-induced catalepsy, a model of extrapyramidal syndrome, in rats when used in combination with the adenosine A2A receptor antagonist ZM 241395 (Item No. 20447).{53483} It reduces thermal hyperalgesia in a rat model of neuropathic pain induced by sciatic nerve ligation when administered at doses of 20 and 30 mg/kg.{53484} Formulations containing ethopropazine were previously used in the treatment of Parkinson’s disease.  

     

    Brand:
    Cayman
    SKU:28493 - 25 mg

    Available on backorder

  • Ethopropazine is a butyrylcholinesterase (BChE) inhibitor (IC50 = 15.14 µM in human erythrocyte lysates).{53481} It is selective for BChE over acetylcholinesterase (AChE) at 500 µM. Ethopropazine also binds to rat forebrain and hindbrain membrane preparations (Kis = 3.1 and 7.2 nM, respectively), which are endogenously enriched in M1 and M2 muscarinic acetylcholine receptors, respectively.{53482} Ethopropazine (0.232 mg/kg) decreases the intensity and increases the latency of haloperidol-induced catalepsy, a model of extrapyramidal syndrome, in rats when used in combination with the adenosine A2A receptor antagonist ZM 241395 (Item No. 20447).{53483} It reduces thermal hyperalgesia in a rat model of neuropathic pain induced by sciatic nerve ligation when administered at doses of 20 and 30 mg/kg.{53484} Formulations containing ethopropazine were previously used in the treatment of Parkinson’s disease.  

     

    Brand:
    Cayman
    SKU:28493 - 50 mg

    Available on backorder

  • Ethosuximide is an anticonvulsant.{36303,36304,36305,36306,36307} It increases glucose, fructose-1,6-bisphosphate, and pyruvate levels in rat brain when administered at a dose of 200 mg/kg.{36303} Ethosuximide (400 mg/kg) reduces the severity of audiogenic seizures in a rat model of barbiturate withdrawal-induced convulsions.{36304} It also inhibits tonic hindlimb extension induced by pentylenetetrazole (PTZ; Item No. 18682) or brainstem stimulation (ED50s = 35 and 70 mg/kg, respectively), as well as leptazol-induced clonic seizures (ED50 = 230 mg/kg), in rats.{36305,36306} Ethosuximide reduces resting tremor by 60% in a macaque model of Parkinson’s disease induced by MPTP when administered at a dose of 150 mg/animal for 5 days.{36307} Formulations containing ethosuximide have been used in the treatment of petit mal seizures.  

     

    Brand:
    Cayman
    SKU:23947 - 1 g

    Available on backorder

  • Ethosuximide is an anticonvulsant.{36303,36304,36305,36306,36307} It increases glucose, fructose-1,6-bisphosphate, and pyruvate levels in rat brain when administered at a dose of 200 mg/kg.{36303} Ethosuximide (400 mg/kg) reduces the severity of audiogenic seizures in a rat model of barbiturate withdrawal-induced convulsions.{36304} It also inhibits tonic hindlimb extension induced by pentylenetetrazole (PTZ; Item No. 18682) or brainstem stimulation (ED50s = 35 and 70 mg/kg, respectively), as well as leptazol-induced clonic seizures (ED50 = 230 mg/kg), in rats.{36305,36306} Ethosuximide reduces resting tremor by 60% in a macaque model of Parkinson’s disease induced by MPTP when administered at a dose of 150 mg/animal for 5 days.{36307} Formulations containing ethosuximide have been used in the treatment of petit mal seizures.  

     

    Brand:
    Cayman
    SKU:23947 - 500 mg

    Available on backorder

  • Ethosuximide-d5 is intended for use as an internal standard for the quantification of ethosuximide (Item No. 23947) by GC- or LC-MS. Ethosuximide is an anticonvulsant.{36303,36304,36305,36306,36307} It increases glucose, fructose-1,6-bisphosphate, and pyruvate levels in rat brain when administered at a dose of 200 mg/kg.{36303} Ethosuximide (400 mg/kg) reduces the severity of audiogenic seizures in a rat model of barbiturate withdrawal-induced convulsions.{36304} It also inhibits tonic hindlimb extension induced by pentylenetetrazole (PTZ; Item No. 18682) or brainstem stimulation (ED50s = 35 and 70 mg/kg, respectively), as well as leptazol-induced clonic seizures (ED50 = 230 mg/kg), in rats.{36305,36306} Ethosuximide reduces resting tremor by 60% in a macaque model of Parkinson’s disease induced by MPTP when administered at a dose of 150 mg/animal for 5 days.{36307} Formulations containing ethosuximide have been used in the treatment of petit mal seizures.  

     

    Brand:
    Cayman
    SKU:30759 - 1 mg

    Available on backorder

  • Ethosuximide-d5 is intended for use as an internal standard for the quantification of ethosuximide (Item No. 23947) by GC- or LC-MS. Ethosuximide is an anticonvulsant.{36303,36304,36305,36306,36307} It increases glucose, fructose-1,6-bisphosphate, and pyruvate levels in rat brain when administered at a dose of 200 mg/kg.{36303} Ethosuximide (400 mg/kg) reduces the severity of audiogenic seizures in a rat model of barbiturate withdrawal-induced convulsions.{36304} It also inhibits tonic hindlimb extension induced by pentylenetetrazole (PTZ; Item No. 18682) or brainstem stimulation (ED50s = 35 and 70 mg/kg, respectively), as well as leptazol-induced clonic seizures (ED50 = 230 mg/kg), in rats.{36305,36306} Ethosuximide reduces resting tremor by 60% in a macaque model of Parkinson’s disease induced by MPTP when administered at a dose of 150 mg/animal for 5 days.{36307} Formulations containing ethosuximide have been used in the treatment of petit mal seizures.  

     

    Brand:
    Cayman
    SKU:30759 - 5 mg

    Available on backorder

  • Ethotoin is a hydantoin anticonvulsant.{37306,37305} It shortens the duration of the tonic extensor aspect of seizures induced by maximal electroshock in rats when administered at doses ranging from 500-1,000 mg/kg.{37305} It also decreases the duration of the tonic phase of seizures at a dose of 1,000 mg/kg but does not affect the duration of the clonic phase at any dose.{37305} Ethotoin (20 mg/kg, i.p.) decreases serum cholesterol and triglyceride concentrations in mice to 67 and 60%, respectively, of control after 16 days of treatment.{37307} Formulations containing ethotoin have been used in the treatment of tonic-clonic and complex partial seizures.  

     

    Brand:
    Cayman
    SKU:24022 - 10 mg

    Available on backorder

  • Ethotoin is a hydantoin anticonvulsant.{37306,37305} It shortens the duration of the tonic extensor aspect of seizures induced by maximal electroshock in rats when administered at doses ranging from 500-1,000 mg/kg.{37305} It also decreases the duration of the tonic phase of seizures at a dose of 1,000 mg/kg but does not affect the duration of the clonic phase at any dose.{37305} Ethotoin (20 mg/kg, i.p.) decreases serum cholesterol and triglyceride concentrations in mice to 67 and 60%, respectively, of control after 16 days of treatment.{37307} Formulations containing ethotoin have been used in the treatment of tonic-clonic and complex partial seizures.  

     

    Brand:
    Cayman
    SKU:24022 - 25 mg

    Available on backorder

  • Ethotoin is a hydantoin anticonvulsant.{37306,37305} It shortens the duration of the tonic extensor aspect of seizures induced by maximal electroshock in rats when administered at doses ranging from 500-1,000 mg/kg.{37305} It also decreases the duration of the tonic phase of seizures at a dose of 1,000 mg/kg but does not affect the duration of the clonic phase at any dose.{37305} Ethotoin (20 mg/kg, i.p.) decreases serum cholesterol and triglyceride concentrations in mice to 67 and 60%, respectively, of control after 16 days of treatment.{37307} Formulations containing ethotoin have been used in the treatment of tonic-clonic and complex partial seizures.  

     

    Brand:
    Cayman
    SKU:24022 - 5 mg

    Available on backorder

  • Ethoxyquin is an antioxidant that is widely used in animal feed to protect against lipid peroxidation and fat rancidity in chicken, salmon, and beef.{36124} In vitro, ethoxyquin protects human lymphocytes against hydrogen peroxide-induced DNA damage and reduces micronuclei formation.{36125} In vivo, it reduces the number of chromosome aberrations, micronuclei, and dominant lethal mutations induced by cyclophosphamide (Item No. 13849) in mice, rats, and Chinese hamsters.{36126,36127} Ethoxyquin also induces chromosome aberrations such as atypical translocations, breaks, and dicentrics in human lymphocytes and CHO cells as well as in vivo kidney and bladder damage in rats.{36124}  

     

    Brand:
    Cayman
    SKU:23094 - 10 g

    Available on backorder

  • Ethoxyquin is an antioxidant that is widely used in animal feed to protect against lipid peroxidation and fat rancidity in chicken, salmon, and beef.{36124} In vitro, ethoxyquin protects human lymphocytes against hydrogen peroxide-induced DNA damage and reduces micronuclei formation.{36125} In vivo, it reduces the number of chromosome aberrations, micronuclei, and dominant lethal mutations induced by cyclophosphamide (Item No. 13849) in mice, rats, and Chinese hamsters.{36126,36127} Ethoxyquin also induces chromosome aberrations such as atypical translocations, breaks, and dicentrics in human lymphocytes and CHO cells as well as in vivo kidney and bladder damage in rats.{36124}  

     

    Brand:
    Cayman
    SKU:23094 - 100 g

    Available on backorder

  • Ethoxyquin is an antioxidant that is widely used in animal feed to protect against lipid peroxidation and fat rancidity in chicken, salmon, and beef.{36124} In vitro, ethoxyquin protects human lymphocytes against hydrogen peroxide-induced DNA damage and reduces micronuclei formation.{36125} In vivo, it reduces the number of chromosome aberrations, micronuclei, and dominant lethal mutations induced by cyclophosphamide (Item No. 13849) in mice, rats, and Chinese hamsters.{36126,36127} Ethoxyquin also induces chromosome aberrations such as atypical translocations, breaks, and dicentrics in human lymphocytes and CHO cells as well as in vivo kidney and bladder damage in rats.{36124}  

     

    Brand:
    Cayman
    SKU:23094 - 25 g

    Available on backorder

  • Ethoxyquin is an antioxidant that is widely used in animal feed to protect against lipid peroxidation and fat rancidity in chicken, salmon, and beef.{36124} In vitro, ethoxyquin protects human lymphocytes against hydrogen peroxide-induced DNA damage and reduces micronuclei formation.{36125} In vivo, it reduces the number of chromosome aberrations, micronuclei, and dominant lethal mutations induced by cyclophosphamide (Item No. 13849) in mice, rats, and Chinese hamsters.{36126,36127} Ethoxyquin also induces chromosome aberrations such as atypical translocations, breaks, and dicentrics in human lymphocytes and CHO cells as well as in vivo kidney and bladder damage in rats.{36124}  

     

    Brand:
    Cayman
    SKU:23094 - 50 g

    Available on backorder

  • Ethoxyquin dimer is an antioxidant and metabolite of ethoxyquin (Item No. 23094).{52295} It prevents oxidation of polyunsaturated fatty acids in fish meal and fish oil. Dietary administration of ethoxyquin dimer (0.1, 0.3, and 0.5% w/w) induces microvesicular steatosis and hepatocyte necrosis, as well as increases liver levels of oxidized glutathione and total lipids in mice.{52296}  

     

    Brand:
    Cayman
    SKU:29823 - 1 mg

    Available on backorder

  • Ethoxyquin dimer is an antioxidant and metabolite of ethoxyquin (Item No. 23094).{52295} It prevents oxidation of polyunsaturated fatty acids in fish meal and fish oil. Dietary administration of ethoxyquin dimer (0.1, 0.3, and 0.5% w/w) induces microvesicular steatosis and hepatocyte necrosis, as well as increases liver levels of oxidized glutathione and total lipids in mice.{52296}  

     

    Brand:
    Cayman
    SKU:29823 - 5 mg

    Available on backorder

  • Ethyl (R)-(-)-3-Hydroxybutyrate is a chiral starting material for the production of numerous biologically active compounds.{32971}  

     

    Brand:
    Cayman
    SKU:20659 -

    Available on backorder

  • Ethyl (R)-(-)-3-Hydroxybutyrate is a chiral starting material for the production of numerous biologically active compounds.{32971}  

     

    Brand:
    Cayman
    SKU:20659 -

    Available on backorder

  • Ethyl (R)-(-)-3-Hydroxybutyrate is a chiral starting material for the production of numerous biologically active compounds.{32971}  

     

    Brand:
    Cayman
    SKU:20659 -

    Available on backorder

  • Ethyl (R)-(-)-3-Hydroxybutyrate is a chiral starting material for the production of numerous biologically active compounds.{32971}  

     

    Brand:
    Cayman
    SKU:20659 -

    Available on backorder

  • ethyl 2-(3-hydroxyphenyl)-4-methylthiazole-5-Carboxylate is a synthetic intermediate useful for pharmaceutical synthesis.  

     

    Brand:
    Cayman
    SKU:11055 - 1 g

    Available on backorder

  • ethyl 2-(3-hydroxyphenyl)-4-methylthiazole-5-Carboxylate is a synthetic intermediate useful for pharmaceutical synthesis.  

     

    Brand:
    Cayman
    SKU:11055 - 5 g

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  • ethyl 2-(3-hydroxyphenyl)-4-methylthiazole-5-Carboxylate is a synthetic intermediate useful for pharmaceutical synthesis.  

     

    Brand:
    Cayman
    SKU:11055 - 500 mg

    Available on backorder

  • Ethyl 2-trans-4-cis-decadienoate is a volatile compound that has been found in pears and has kairomonal attractant activity.{57220} Ethyl 2-trans-4-cis-decadienoate attracts male and female codling moths (C. pomonella), an apple, pear, and walnut pest, to traps placed in orchards when applied at a concentration of 40 mg/trap. It also attracts C. splendana males and females, as well as P. fasciana males.  

     

    Brand:
    Cayman
    SKU:30835 - 10 g

    Available on backorder

  • Ethyl 2-trans-4-cis-decadienoate is a volatile compound that has been found in pears and has kairomonal attractant activity.{57220} Ethyl 2-trans-4-cis-decadienoate attracts male and female codling moths (C. pomonella), an apple, pear, and walnut pest, to traps placed in orchards when applied at a concentration of 40 mg/trap. It also attracts C. splendana males and females, as well as P. fasciana males.  

     

    Brand:
    Cayman
    SKU:30835 - 100 g

    Available on backorder

  • Ethyl 2-trans-4-cis-decadienoate is a volatile compound that has been found in pears and has kairomonal attractant activity.{57220} Ethyl 2-trans-4-cis-decadienoate attracts male and female codling moths (C. pomonella), an apple, pear, and walnut pest, to traps placed in orchards when applied at a concentration of 40 mg/trap. It also attracts C. splendana males and females, as well as P. fasciana males.  

     

    Brand:
    Cayman
    SKU:30835 - 50 g

    Available on backorder

  • ethyl 2,5-Dihydroxybenzoate is a dual modulator of bone cell differentiation. It promotes osteoblast differentiation, enhancing alkaline phosphatase activity, osteocalcin expression, and calcium deposition in human mesenchymal stem cells.{33149} ethyl 2,5-Dihydroxybenzoate also inhibits RANKL-activated osteoclastogenesis in RAW 264.7 cells.{33149}  

     

    Brand:
    Cayman
    SKU:21013 -

    Out of stock

  • ethyl 2,5-Dihydroxybenzoate is a dual modulator of bone cell differentiation. It promotes osteoblast differentiation, enhancing alkaline phosphatase activity, osteocalcin expression, and calcium deposition in human mesenchymal stem cells.{33149} ethyl 2,5-Dihydroxybenzoate also inhibits RANKL-activated osteoclastogenesis in RAW 264.7 cells.{33149}  

     

    Brand:
    Cayman
    SKU:21013 -

    Out of stock

  • ethyl 2,5-Dihydroxybenzoate is a dual modulator of bone cell differentiation. It promotes osteoblast differentiation, enhancing alkaline phosphatase activity, osteocalcin expression, and calcium deposition in human mesenchymal stem cells.{33149} ethyl 2,5-Dihydroxybenzoate also inhibits RANKL-activated osteoclastogenesis in RAW 264.7 cells.{33149}  

     

    Brand:
    Cayman
    SKU:21013 -

    Out of stock

  • Ethyl 3-aminobenzoate (methanesulfonate), a hydrophilic derivative of benzocaine (Item No. 20132), is an anesthetic used by hatcheries and in research studies to immobilize fish for marking, transport, or to suppress sensory systems during invasive procedures such as the implantation of electronic tags.{32566,32567}  

     

    Brand:
    Cayman
    SKU:20660 -

    Available on backorder

  • Ethyl 3-aminobenzoate (methanesulfonate), a hydrophilic derivative of benzocaine (Item No. 20132), is an anesthetic used by hatcheries and in research studies to immobilize fish for marking, transport, or to suppress sensory systems during invasive procedures such as the implantation of electronic tags.{32566,32567}  

     

    Brand:
    Cayman
    SKU:20660 -

    Available on backorder

  • Ethyl 3-aminobenzoate (methanesulfonate), a hydrophilic derivative of benzocaine (Item No. 20132), is an anesthetic used by hatcheries and in research studies to immobilize fish for marking, transport, or to suppress sensory systems during invasive procedures such as the implantation of electronic tags.{32566,32567}  

     

    Brand:
    Cayman
    SKU:20660 -

    Available on backorder

  • Ethyl 3-aminobenzoate (methanesulfonate), a hydrophilic derivative of benzocaine (Item No. 20132), is an anesthetic used by hatcheries and in research studies to immobilize fish for marking, transport, or to suppress sensory systems during invasive procedures such as the implantation of electronic tags.{32566,32567}  

     

    Brand:
    Cayman
    SKU:20660 -

    Available on backorder

  • ethyl 4-methyl-2-(2-thienyl)-thiazole-5 Carboxylate is a synthetic intermediate useful for pharmaceutical synthesis.  

     

    Brand:
    Cayman
    SKU:11056 - 1 g

    Available on backorder

  • ethyl 4-methyl-2-(2-thienyl)-thiazole-5 Carboxylate is a synthetic intermediate useful for pharmaceutical synthesis.  

     

    Brand:
    Cayman
    SKU:11056 - 5 g

    Available on backorder

  • ethyl 4-methyl-2-(2-thienyl)-thiazole-5 Carboxylate is a synthetic intermediate useful for pharmaceutical synthesis.  

     

    Brand:
    Cayman
    SKU:11056 - 500 mg

    Available on backorder

  • Ethyl 4-nitro-L-phenylalanine is a building block.{32621,58083} It has been used in the synthesis of chemokine (C-C motif) receptor 3 (CCR3) antagonists, as well as α4β1 (VLA-4) integrin antagonists.  

     

    Brand:
    Cayman
    SKU:30615 - 1 g

    Available on backorder

  • Ethyl 4-nitro-L-phenylalanine is a building block.{32621,58083} It has been used in the synthesis of chemokine (C-C motif) receptor 3 (CCR3) antagonists, as well as α4β1 (VLA-4) integrin antagonists.  

     

    Brand:
    Cayman
    SKU:30615 - 5 g

    Available on backorder

  • Ethyl 4-nitro-L-phenylalanine is a building block.{32621,58083} It has been used in the synthesis of chemokine (C-C motif) receptor 3 (CCR3) antagonists, as well as α4β1 (VLA-4) integrin antagonists.  

     

    Brand:
    Cayman
    SKU:30615 - 500 mg

    Available on backorder

  • Ethyl orsellinate is a lichen metabolite and a derivative of lecanoric acid (Item No. 22710) that has antiproliferative activities.{41961,41962} It inhibits the proliferation of human Hep-2 larynx carcinoma, MCF-7 breast cancer, and 786-0 kidney carcinoma cells, as well as B16-F10 murine melanoma and non-cancerous Vero cells (IC50s = 31.2, 70.3, 47.5, 64.8, and 28.1 µg/ml, respectively).{41962} Ethyl orsellinate is toxic to brine shrimp (A. salina) with an LC50 value of 495 µM.{41963}  

     

    Brand:
    Cayman
    SKU:22709 -

    Out of stock

  • Ethyl orsellinate is a lichen metabolite and a derivative of lecanoric acid (Item No. 22710) that has antiproliferative activities.{41961,41962} It inhibits the proliferation of human Hep-2 larynx carcinoma, MCF-7 breast cancer, and 786-0 kidney carcinoma cells, as well as B16-F10 murine melanoma and non-cancerous Vero cells (IC50s = 31.2, 70.3, 47.5, 64.8, and 28.1 µg/ml, respectively).{41962} Ethyl orsellinate is toxic to brine shrimp (A. salina) with an LC50 value of 495 µM.{41963}  

     

    Brand:
    Cayman
    SKU:22709 -

    Out of stock

  • Ethyl p-methoxycinnamate (EPMC) is a natural product found in K. galanga and C. zedoaria extracts with anti-inflammatory, antiangiogenic, antifungal, larvicidal, and analgesic activities.{36073,36074,36075,36076} It inhibits COX-1 and COX-2 in vitro (IC50s = 1.12 and 0.83 μM, respectively) and reduces IL-1 and TNF-α production in vivo.{36075,36076} EPMC inhibits granuloma tissue formation and acts as an analgesic, delaying tail flick time, in a dose-dependent manner in rats.{36076} It inhibits blood vessel growth in rat aortic explants (IC50 = 91.9 μg/ml). EPMC (T. rubrum, A. niger, S. cerevisiae, and E. floccosum and is larvicidal (LC50 = 53.64 ppm) against Ae. aegypti.{36073,36074}  

     

    Brand:
    Cayman
    SKU:11740 - 100 mg

    Available on backorder

  • Ethyl p-methoxycinnamate (EPMC) is a natural product found in K. galanga and C. zedoaria extracts with anti-inflammatory, antiangiogenic, antifungal, larvicidal, and analgesic activities.{36073,36074,36075,36076} It inhibits COX-1 and COX-2 in vitro (IC50s = 1.12 and 0.83 μM, respectively) and reduces IL-1 and TNF-α production in vivo.{36075,36076} EPMC inhibits granuloma tissue formation and acts as an analgesic, delaying tail flick time, in a dose-dependent manner in rats.{36076} It inhibits blood vessel growth in rat aortic explants (IC50 = 91.9 μg/ml). EPMC (T. rubrum, A. niger, S. cerevisiae, and E. floccosum and is larvicidal (LC50 = 53.64 ppm) against Ae. aegypti.{36073,36074}  

     

    Brand:
    Cayman
    SKU:11740 - 50 mg

    Available on backorder

  • Ethyl tricosanoate, a long chain saturated fatty acid ethyl ester, is found in small quantities in liverwort, C. conicum.{14238} The free acid decreases the hemolytic activity of Staphylococcus aureus delta toxin on human erythrocytes.{14239} Both the ethyl ester and the free acid can be used as standards for analysis of lipid mixtures.  

     

    Brand:
    Cayman
    SKU:10006874 - 10 mg

    Available on backorder

  • Ethyl tricosanoate, a long chain saturated fatty acid ethyl ester, is found in small quantities in liverwort, C. conicum.{14238} The free acid decreases the hemolytic activity of Staphylococcus aureus delta toxin on human erythrocytes.{14239} Both the ethyl ester and the free acid can be used as standards for analysis of lipid mixtures.  

     

    Brand:
    Cayman
    SKU:10006874 - 100 mg

    Available on backorder

  • Ethyl tricosanoate, a long chain saturated fatty acid ethyl ester, is found in small quantities in liverwort, C. conicum.{14238} The free acid decreases the hemolytic activity of Staphylococcus aureus delta toxin on human erythrocytes.{14239} Both the ethyl ester and the free acid can be used as standards for analysis of lipid mixtures.  

     

    Brand:
    Cayman
    SKU:10006874 - 5 mg

    Available on backorder

  • Ethyl tricosanoate, a long chain saturated fatty acid ethyl ester, is found in small quantities in liverwort, C. conicum.{14238} The free acid decreases the hemolytic activity of Staphylococcus aureus delta toxin on human erythrocytes.{14239} Both the ethyl ester and the free acid can be used as standards for analysis of lipid mixtures.  

     

    Brand:
    Cayman
    SKU:10006874 - 50 mg

    Available on backorder

  • ethyl-2-(2-pyridyl)-4-(bromomethyl)-Thiazole-5-carboxylate is a synthetic intermediate useful for pharmaceutical synthesis.  

     

    Brand:
    Cayman
    SKU:13007 - 1 g

    Available on backorder

  • ethyl-2-(2-pyridyl)-4-(bromomethyl)-Thiazole-5-carboxylate is a synthetic intermediate useful for pharmaceutical synthesis.  

     

    Brand:
    Cayman
    SKU:13007 - 100 mg

    Available on backorder

  • ethyl-2-(2-pyridyl)-4-(bromomethyl)-Thiazole-5-carboxylate is a synthetic intermediate useful for pharmaceutical synthesis.  

     

    Brand:
    Cayman
    SKU:13007 - 250 mg

    Available on backorder

  • ethyl-2-(2-pyridyl)-4-(bromomethyl)-Thiazole-5-carboxylate is a synthetic intermediate useful for pharmaceutical synthesis.  

     

    Brand:
    Cayman
    SKU:13007 - 500 mg

    Available on backorder

  • ethyl-2-amino-4-methyl-Thiazole-5-carboxylate is a synthetic intermediate useful for pharmaceutical synthesis.  

     

    Brand:
    Cayman
    SKU:13059 - 1 g

    Available on backorder

  • ethyl-2-amino-4-methyl-Thiazole-5-carboxylate is a synthetic intermediate useful for pharmaceutical synthesis.  

     

    Brand:
    Cayman
    SKU:13059 - 250 mg

    Available on backorder

  • ethyl-2-amino-4-methyl-Thiazole-5-carboxylate is a synthetic intermediate useful for pharmaceutical synthesis.  

     

    Brand:
    Cayman
    SKU:13059 - 5 g

    Available on backorder

  • ethyl-2-amino-4-methyl-Thiazole-5-carboxylate is a synthetic intermediate useful for pharmaceutical synthesis.  

     

    Brand:
    Cayman
    SKU:13059 - 500 mg

    Available on backorder

  • ethyl-2-amino-4-phenyl-Thiophene-3-carboxylate is a synthetic intermediate useful for pharmaceutical synthesis.  

     

    Brand:
    Cayman
    SKU:-
  • ethyl-2-amino-4-phenyl-Thiophene-3-carboxylate is a synthetic intermediate useful for pharmaceutical synthesis.  

     

    Brand:
    Cayman
    SKU:-
  • ethyl-2-amino-4-phenyl-Thiophene-3-carboxylate is a synthetic intermediate useful for pharmaceutical synthesis.  

     

    Brand:
    Cayman
    SKU:-
  • ethyl-2-amino-4-phenyl-Thiophene-3-carboxylate is a synthetic intermediate useful for pharmaceutical synthesis.  

     

    Brand:
    Cayman
    SKU:-
  • ethyl-2,4-dimethyl-Thiazole-5-carboxylate is a highly functionalized and biased thiazole used for drug discovery. It is used as a heterocyclic building block to specifically modify lead compounds.  

     

    Brand:
    Cayman
    SKU:-
  • ethyl-2,4-dimethyl-Thiazole-5-carboxylate is a highly functionalized and biased thiazole used for drug discovery. It is used as a heterocyclic building block to specifically modify lead compounds.  

     

    Brand:
    Cayman
    SKU:-
  • ethyl-2,4-dimethyl-Thiazole-5-carboxylate is a highly functionalized and biased thiazole used for drug discovery. It is used as a heterocyclic building block to specifically modify lead compounds.  

     

    Brand:
    Cayman
    SKU:-
  • ethyl-2,4-dimethyl-Thiazole-5-carboxylate is a highly functionalized and biased thiazole used for drug discovery. It is used as a heterocyclic building block to specifically modify lead compounds.  

     

    Brand:
    Cayman
    SKU:-
  • Ethyl-L-NIO, the saturated analog of vinyl-L-NIO, is a modestly selective NOS inhibitor. The Ki values for inhibition of nNOS, eNOS, and iNOS by ethyl-L-NIO are 5.3, 18, and 12 µM, respectively, as determined using initial rate measurements.{6358} However when evaluating the Ki/Km ratio, ethyl-L-NIO does not show biologically significant selectivity for nNOS over eNOS, and instead favors iNOS (Ki/Km = 3.79, 5, and 0.96 µM, respectively).{6358} Although ethyl-L-NIO inhibits nNOS, it does not inactivate nNOS in the presence of NADPH and O2.{6358}  

     

    Brand:
    Cayman
    SKU:10012088 - 10 mg

    Available on backorder

  • Ethyl-L-NIO, the saturated analog of vinyl-L-NIO, is a modestly selective NOS inhibitor. The Ki values for inhibition of nNOS, eNOS, and iNOS by ethyl-L-NIO are 5.3, 18, and 12 µM, respectively, as determined using initial rate measurements.{6358} However when evaluating the Ki/Km ratio, ethyl-L-NIO does not show biologically significant selectivity for nNOS over eNOS, and instead favors iNOS (Ki/Km = 3.79, 5, and 0.96 µM, respectively).{6358} Although ethyl-L-NIO inhibits nNOS, it does not inactivate nNOS in the presence of NADPH and O2.{6358}  

     

    Brand:
    Cayman
    SKU:10012088 - 100 mg

    Available on backorder

  • Ethyl-L-NIO, the saturated analog of vinyl-L-NIO, is a modestly selective NOS inhibitor. The Ki values for inhibition of nNOS, eNOS, and iNOS by ethyl-L-NIO are 5.3, 18, and 12 µM, respectively, as determined using initial rate measurements.{6358} However when evaluating the Ki/Km ratio, ethyl-L-NIO does not show biologically significant selectivity for nNOS over eNOS, and instead favors iNOS (Ki/Km = 3.79, 5, and 0.96 µM, respectively).{6358} Although ethyl-L-NIO inhibits nNOS, it does not inactivate nNOS in the presence of NADPH and O2.{6358}  

     

    Brand:
    Cayman
    SKU:10012088 - 5 mg

    Available on backorder

  • Ethyl-L-NIO, the saturated analog of vinyl-L-NIO, is a modestly selective NOS inhibitor. The Ki values for inhibition of nNOS, eNOS, and iNOS by ethyl-L-NIO are 5.3, 18, and 12 µM, respectively, as determined using initial rate measurements.{6358} However when evaluating the Ki/Km ratio, ethyl-L-NIO does not show biologically significant selectivity for nNOS over eNOS, and instead favors iNOS (Ki/Km = 3.79, 5, and 0.96 µM, respectively).{6358} Although ethyl-L-NIO inhibits nNOS, it does not inactivate nNOS in the presence of NADPH and O2.{6358}  

     

    Brand:
    Cayman
    SKU:10012088 - 50 mg

    Available on backorder

  • Ethynodiol diacetate is a synthetic progestogen.{53485} It prevents the development of osteoporosis in ovariectomized rats when administered at a dose of 9 µg/animal per day. Ethynodiol diacetate inhibits copulatory ovulation in rabbits.{53486} Formulations containing ethynodiol diacetate have been used as oral contraceptives.  

     

    Brand:
    Cayman
    SKU:29854 - 1 g

    Available on backorder

  • Ethynodiol diacetate is a synthetic progestogen.{53485} It prevents the development of osteoporosis in ovariectomized rats when administered at a dose of 9 µg/animal per day. Ethynodiol diacetate inhibits copulatory ovulation in rabbits.{53486} Formulations containing ethynodiol diacetate have been used as oral contraceptives.  

     

    Brand:
    Cayman
    SKU:29854 - 5 g

    Available on backorder

  • Ethynodiol diacetate is a synthetic progestogen.{53485} It prevents the development of osteoporosis in ovariectomized rats when administered at a dose of 9 µg/animal per day. Ethynodiol diacetate inhibits copulatory ovulation in rabbits.{53486} Formulations containing ethynodiol diacetate have been used as oral contraceptives.  

     

    Brand:
    Cayman
    SKU:29854 - 500 mg

    Available on backorder

  • Estrogens direct the development of the female genotype in embryogenesis and at puberty. Estradiol is the major estrogen secreted by the premenopausal ovary.{9611} Ethynyl estradiol is a synthetic analog of 17β-estradiol (Item No. 10006315). A USP-approved grade of ethynyl estradiol is often formulated in combination with a progestin such as norgestrel (Item No. 10006319)/levonorgestrel (Item No. 10006318) or desogestrel and provided for use as an oral contraceptive. Efficacy of oral administration of ethynyl estradiol is facilitated by the ethynyl substitution at the C-17 position, which inhibits first pass hepatic metabolism. Ethynyl estradiol is also rapidly and almost completely absorbed from the gastrointestinal tract.{12906}  

     

    Brand:
    Cayman
    SKU:10006486 - 1 g

    Available on backorder

  • Estrogens direct the development of the female genotype in embryogenesis and at puberty. Estradiol is the major estrogen secreted by the premenopausal ovary.{9611} Ethynyl estradiol is a synthetic analog of 17β-estradiol (Item No. 10006315). A USP-approved grade of ethynyl estradiol is often formulated in combination with a progestin such as norgestrel (Item No. 10006319)/levonorgestrel (Item No. 10006318) or desogestrel and provided for use as an oral contraceptive. Efficacy of oral administration of ethynyl estradiol is facilitated by the ethynyl substitution at the C-17 position, which inhibits first pass hepatic metabolism. Ethynyl estradiol is also rapidly and almost completely absorbed from the gastrointestinal tract.{12906}  

     

    Brand:
    Cayman
    SKU:10006486 - 5 g

    Available on backorder

  • Estrogens direct the development of the female genotype in embryogenesis and at puberty. Estradiol is the major estrogen secreted by the premenopausal ovary.{9611} Ethynyl estradiol is a synthetic analog of 17β-estradiol (Item No. 10006315). A USP-approved grade of ethynyl estradiol is often formulated in combination with a progestin such as norgestrel (Item No. 10006319)/levonorgestrel (Item No. 10006318) or desogestrel and provided for use as an oral contraceptive. Efficacy of oral administration of ethynyl estradiol is facilitated by the ethynyl substitution at the C-17 position, which inhibits first pass hepatic metabolism. Ethynyl estradiol is also rapidly and almost completely absorbed from the gastrointestinal tract.{12906}  

     

    Brand:
    Cayman
    SKU:10006486 - 500 mg

    Available on backorder

  • Ethynylcitidine (ECyD) is a nucleoside analog with anticancer activity.{55062,55061} It is cytotoxic to A549, NUGC-3, HT-29, MIA PaCa-2, and MCF-7 cancer cells (IC50s = 0.114, 1.032, 0.539, 0.198, and 0.326 µM, respectively).{55062} ECyD (0.25 mg/kg per day) reduces tumor growth in CADO-LC11 lung, PAN-12 pancreas, AZ-521 stomach, and CO-3 colon cancer mouse xenograft models.{55061}  

     

    Brand:
    Cayman
    SKU:27681 - 1 mg

    Available on backorder

  • Ethynylcitidine (ECyD) is a nucleoside analog with anticancer activity.{55062,55061} It is cytotoxic to A549, NUGC-3, HT-29, MIA PaCa-2, and MCF-7 cancer cells (IC50s = 0.114, 1.032, 0.539, 0.198, and 0.326 µM, respectively).{55062} ECyD (0.25 mg/kg per day) reduces tumor growth in CADO-LC11 lung, PAN-12 pancreas, AZ-521 stomach, and CO-3 colon cancer mouse xenograft models.{55061}  

     

    Brand:
    Cayman
    SKU:27681 - 10 mg

    Available on backorder

  • Ethynylcitidine (ECyD) is a nucleoside analog with anticancer activity.{55062,55061} It is cytotoxic to A549, NUGC-3, HT-29, MIA PaCa-2, and MCF-7 cancer cells (IC50s = 0.114, 1.032, 0.539, 0.198, and 0.326 µM, respectively).{55062} ECyD (0.25 mg/kg per day) reduces tumor growth in CADO-LC11 lung, PAN-12 pancreas, AZ-521 stomach, and CO-3 colon cancer mouse xenograft models.{55061}  

     

    Brand:
    Cayman
    SKU:27681 - 5 mg

    Available on backorder

  • Eticlopride is a dopamine D2 and D3 receptor antagonist (Kis = 0.029 and 0.46 nM in MN9D mouse neuronal cells expressing rat D2 and human D3 receptors, respectively).{45603} It is selective for dopamine D2 and D3 receptors (IC50s = 1 and 113 nM, respectively) over dopamine D1, α2-adrenergic, and β-adrenergic, histamine H1, and muscarinic receptors (IC50s = 700->100,000 nM), as well as the serotonin (5-HT) receptor subtypes 5-HT1 and 5-HT2 (IC50s = 6,200 and 830, respectively), but does bind α1-adrenergic receptors (α1-ARs; IC50 = 110 nM) in radioligand binding assays.{45604} Eticlopride (10 μg/kg) inhibits stereotyped behavior in rats induced by 7-hydroxy-N,N-di-n-propyl-2-aminotetralin (7-OH-DPAT).{45605} It also inhibits ketamine- and cocaine-induced hypermotility in rats when administered at doses of 20 and 50 μg/kg, respectively.  

     

    Brand:
    Cayman
    SKU:29112 - 10 mg

    Available on backorder

  • Eticlopride is a dopamine D2 and D3 receptor antagonist (Kis = 0.029 and 0.46 nM in MN9D mouse neuronal cells expressing rat D2 and human D3 receptors, respectively).{45603} It is selective for dopamine D2 and D3 receptors (IC50s = 1 and 113 nM, respectively) over dopamine D1, α2-adrenergic, and β-adrenergic, histamine H1, and muscarinic receptors (IC50s = 700->100,000 nM), as well as the serotonin (5-HT) receptor subtypes 5-HT1 and 5-HT2 (IC50s = 6,200 and 830, respectively), but does bind α1-adrenergic receptors (α1-ARs; IC50 = 110 nM) in radioligand binding assays.{45604} Eticlopride (10 μg/kg) inhibits stereotyped behavior in rats induced by 7-hydroxy-N,N-di-n-propyl-2-aminotetralin (7-OH-DPAT).{45605} It also inhibits ketamine- and cocaine-induced hypermotility in rats when administered at doses of 20 and 50 μg/kg, respectively.  

     

    Brand:
    Cayman
    SKU:29112 - 25 mg

    Available on backorder

  • Eticlopride is a dopamine D2 and D3 receptor antagonist (Kis = 0.029 and 0.46 nM in MN9D mouse neuronal cells expressing rat D2 and human D3 receptors, respectively).{45603} It is selective for dopamine D2 and D3 receptors (IC50s = 1 and 113 nM, respectively) over dopamine D1, α2-adrenergic, and β-adrenergic, histamine H1, and muscarinic receptors (IC50s = 700->100,000 nM), as well as the serotonin (5-HT) receptor subtypes 5-HT1 and 5-HT2 (IC50s = 6,200 and 830, respectively), but does bind α1-adrenergic receptors (α1-ARs; IC50 = 110 nM) in radioligand binding assays.{45604} Eticlopride (10 μg/kg) inhibits stereotyped behavior in rats induced by 7-hydroxy-N,N-di-n-propyl-2-aminotetralin (7-OH-DPAT).{45605} It also inhibits ketamine- and cocaine-induced hypermotility in rats when administered at doses of 20 and 50 μg/kg, respectively.  

     

    Brand:
    Cayman
    SKU:29112 - 5 mg

    Available on backorder

  • Etidronate is a first generation, non-nitrogenous diphosphonate analog of endogenous pyrophosphate. It binds to hydroxyapatite and induces osteoclast apoptosis, thereby inhibiting abnormal bone resorption.{32837} Unlike other bisphosphonates, etidronate may also prevent bone calcification.  

     

    Brand:
    Cayman
    SKU:20769 -

    Available on backorder

  • Etidronate is a first generation, non-nitrogenous diphosphonate analog of endogenous pyrophosphate. It binds to hydroxyapatite and induces osteoclast apoptosis, thereby inhibiting abnormal bone resorption.{32837} Unlike other bisphosphonates, etidronate may also prevent bone calcification.  

     

    Brand:
    Cayman
    SKU:20769 -

    Available on backorder

  • Etidronate is a first generation, non-nitrogenous diphosphonate analog of endogenous pyrophosphate. It binds to hydroxyapatite and induces osteoclast apoptosis, thereby inhibiting abnormal bone resorption.{32837} Unlike other bisphosphonates, etidronate may also prevent bone calcification.  

     

    Brand:
    Cayman
    SKU:20769 -

    Available on backorder

  • Etidronate is a first generation, non-nitrogenous diphosphonate analog of endogenous pyrophosphate. It binds to hydroxyapatite and induces osteoclast apoptosis, thereby inhibiting abnormal bone resorption.{32837} Unlike other bisphosphonates, etidronate may also prevent bone calcification.  

     

    Brand:
    Cayman
    SKU:20769 -

    Available on backorder

  • Etifoxine is a positive allosteric modulator of α1β2γ2 and α1β3γ2 subunit-containing GABAA receptors.{26117} It selectively increases GABA-induced currents in X. laevis oocytes expressing α1β2γ2 or α1β3γ2 over α1β1γ2 subunit-containing receptors at 20 µM. Etifoxine inhibits binding of the GABAA receptor agonist muscimol in rat corticol membranes with a Kd value of 23 nM in a radioligand binding assay.{53410} It increases NGF-induced neurite outgrowth in PC12 cells when used at a concentration of 20 µM.{26118} Etifoxine (12.5 mg/kg, i.p.) increases the percentage of time spent in the open arms of the elevated plus maze in high-anxiety BALB/cByJ, but not C57BL/6, mice, indicating anxiolytic-like activity.{53411} It increases the seizure threshold in a mouse model of seizures induced by picrotoxin (Item No. 20771) with a minimum effective dose (MED) of 75 mg/kg.{53410} Etifoxine (50 mg/kg, i.p.) also increases the paw withdrawal threshold on the ipsilateral side in a rat model of rheumatoid arthritis induced by complete Freund’s adjuvant.{53412}  

     

    Brand:
    Cayman
    SKU:-
  • Etifoxine is a positive allosteric modulator of α1β2γ2 and α1β3γ2 subunit-containing GABAA receptors.{26117} It selectively increases GABA-induced currents in X. laevis oocytes expressing α1β2γ2 or α1β3γ2 over α1β1γ2 subunit-containing receptors at 20 µM. Etifoxine inhibits binding of the GABAA receptor agonist muscimol in rat corticol membranes with a Kd value of 23 nM in a radioligand binding assay.{53410} It increases NGF-induced neurite outgrowth in PC12 cells when used at a concentration of 20 µM.{26118} Etifoxine (12.5 mg/kg, i.p.) increases the percentage of time spent in the open arms of the elevated plus maze in high-anxiety BALB/cByJ, but not C57BL/6, mice, indicating anxiolytic-like activity.{53411} It increases the seizure threshold in a mouse model of seizures induced by picrotoxin (Item No. 20771) with a minimum effective dose (MED) of 75 mg/kg.{53410} Etifoxine (50 mg/kg, i.p.) also increases the paw withdrawal threshold on the ipsilateral side in a rat model of rheumatoid arthritis induced by complete Freund’s adjuvant.{53412}  

     

    Brand:
    Cayman
    SKU:-
  • Etifoxine is a positive allosteric modulator of α1β2γ2 and α1β3γ2 subunit-containing GABAA receptors.{26117} It selectively increases GABA-induced currents in X. laevis oocytes expressing α1β2γ2 or α1β3γ2 over α1β1γ2 subunit-containing receptors at 20 µM. Etifoxine inhibits binding of the GABAA receptor agonist muscimol in rat corticol membranes with a Kd value of 23 nM in a radioligand binding assay.{53410} It increases NGF-induced neurite outgrowth in PC12 cells when used at a concentration of 20 µM.{26118} Etifoxine (12.5 mg/kg, i.p.) increases the percentage of time spent in the open arms of the elevated plus maze in high-anxiety BALB/cByJ, but not C57BL/6, mice, indicating anxiolytic-like activity.{53411} It increases the seizure threshold in a mouse model of seizures induced by picrotoxin (Item No. 20771) with a minimum effective dose (MED) of 75 mg/kg.{53410} Etifoxine (50 mg/kg, i.p.) also increases the paw withdrawal threshold on the ipsilateral side in a rat model of rheumatoid arthritis induced by complete Freund’s adjuvant.{53412}  

     

    Brand:
    Cayman
    SKU:-
  • Etifoxine is a positive allosteric modulator of α1β2γ2 and α1β3γ2 subunit-containing GABAA receptors.{26117} It selectively increases GABA-induced currents in X. laevis oocytes expressing α1β2γ2 or α1β3γ2 over α1β1γ2 subunit-containing receptors at 20 µM. Etifoxine inhibits binding of the GABAA receptor agonist muscimol in rat corticol membranes with a Kd value of 23 nM in a radioligand binding assay.{53410} It increases NGF-induced neurite outgrowth in PC12 cells when used at a concentration of 20 µM.{26118} Etifoxine (12.5 mg/kg, i.p.) increases the percentage of time spent in the open arms of the elevated plus maze in high-anxiety BALB/cByJ, but not C57BL/6, mice, indicating anxiolytic-like activity.{53411} It increases the seizure threshold in a mouse model of seizures induced by picrotoxin (Item No. 20771) with a minimum effective dose (MED) of 75 mg/kg.{53410} Etifoxine (50 mg/kg, i.p.) also increases the paw withdrawal threshold on the ipsilateral side in a rat model of rheumatoid arthritis induced by complete Freund’s adjuvant.{53412}  

     

    Brand:
    Cayman
    SKU:-
  • Etodolac is a non-steroidal anti-inflammatory drug (NSAID) that inhibits both COX isoforms in vitro, with modest selectivity for COX-2 (IC50s = 12 µM for COX-1 and 2.2 µM for COX-2 in a human whole blood assay).{8427} Experimental evidence suggests that etodolac may have favorable tissue pharmacokinetics resulting in further COX-2 selectivity, indicated by favorable reduction in anti-inflammatory action with diminished gastric side effects.{4067,11268}  

     

    Brand:
    Cayman
    SKU:20833 -

    Out of stock

  • Etodolac is a non-steroidal anti-inflammatory drug (NSAID) that inhibits both COX isoforms in vitro, with modest selectivity for COX-2 (IC50s = 12 µM for COX-1 and 2.2 µM for COX-2 in a human whole blood assay).{8427} Experimental evidence suggests that etodolac may have favorable tissue pharmacokinetics resulting in further COX-2 selectivity, indicated by favorable reduction in anti-inflammatory action with diminished gastric side effects.{4067,11268}  

     

    Brand:
    Cayman
    SKU:20833 -

    Out of stock

  • Etodolac is a non-steroidal anti-inflammatory drug (NSAID) that inhibits both COX isoforms in vitro, with modest selectivity for COX-2 (IC50s = 12 µM for COX-1 and 2.2 µM for COX-2 in a human whole blood assay).{8427} Experimental evidence suggests that etodolac may have favorable tissue pharmacokinetics resulting in further COX-2 selectivity, indicated by favorable reduction in anti-inflammatory action with diminished gastric side effects.{4067,11268}  

     

    Brand:
    Cayman
    SKU:20833 -

    Out of stock

  • Etodolac is a non-steroidal anti-inflammatory drug (NSAID) that inhibits both COX isoforms in vitro, with modest selectivity for COX-2 (IC50s = 12 µM for COX-1 and 2.2 µM for COX-2 in a human whole blood assay).{8427} Experimental evidence suggests that etodolac may have favorable tissue pharmacokinetics resulting in further COX-2 selectivity, indicated by favorable reduction in anti-inflammatory action with diminished gastric side effects.{4067,11268}  

     

    Brand:
    Cayman
    SKU:20833 -

    Out of stock

  • Etofenamate is a non-steroidal anti-inflammatory drug (NSAID) and diethylene glycol ester form of flufenamic acid (Item No. 21447) that has anti-inflammatory and analgesic activities.{41244,41245} It inhibits lipoxygenase isolated from guinea pig leukocytes (IC50 = 5.3 μM) and the production of prostaglandin E2 (PGE2; Item No. 14010) in stimulated rat peritoneal macrophages.{41245} In vivo, etofenamate reduces acetic acid-induced vascular permeability in mice and UV-induced erythema in guinea pigs in a dose-dependent manner at doses ranging from 40-320 and 5-20 mg/kg, respectively.{41244} Etofenamate (40 mg/kg per day for 21 days) inhibits inflammation in a rat model of adjuvant-induced arthritis. It also decreases the pain response in a silver nitrate-induced rat model of arthritis and the acetic acid-induced writhing test in mice, indicating analgesic activity. Formulations containing etofenamate have been used in the treatment of osteoarthritis.  

     

    Brand:
    Cayman
    SKU:23674 - 100 mg

    Available on backorder

  • Etofenamate is a non-steroidal anti-inflammatory drug (NSAID) and diethylene glycol ester form of flufenamic acid (Item No. 21447) that has anti-inflammatory and analgesic activities.{41244,41245} It inhibits lipoxygenase isolated from guinea pig leukocytes (IC50 = 5.3 μM) and the production of prostaglandin E2 (PGE2; Item No. 14010) in stimulated rat peritoneal macrophages.{41245} In vivo, etofenamate reduces acetic acid-induced vascular permeability in mice and UV-induced erythema in guinea pigs in a dose-dependent manner at doses ranging from 40-320 and 5-20 mg/kg, respectively.{41244} Etofenamate (40 mg/kg per day for 21 days) inhibits inflammation in a rat model of adjuvant-induced arthritis. It also decreases the pain response in a silver nitrate-induced rat model of arthritis and the acetic acid-induced writhing test in mice, indicating analgesic activity. Formulations containing etofenamate have been used in the treatment of osteoarthritis.  

     

    Brand:
    Cayman
    SKU:23674 - 250 mg

    Available on backorder

  • Etofenamate is a non-steroidal anti-inflammatory drug (NSAID) and diethylene glycol ester form of flufenamic acid (Item No. 21447) that has anti-inflammatory and analgesic activities.{41244,41245} It inhibits lipoxygenase isolated from guinea pig leukocytes (IC50 = 5.3 μM) and the production of prostaglandin E2 (PGE2; Item No. 14010) in stimulated rat peritoneal macrophages.{41245} In vivo, etofenamate reduces acetic acid-induced vascular permeability in mice and UV-induced erythema in guinea pigs in a dose-dependent manner at doses ranging from 40-320 and 5-20 mg/kg, respectively.{41244} Etofenamate (40 mg/kg per day for 21 days) inhibits inflammation in a rat model of adjuvant-induced arthritis. It also decreases the pain response in a silver nitrate-induced rat model of arthritis and the acetic acid-induced writhing test in mice, indicating analgesic activity. Formulations containing etofenamate have been used in the treatment of osteoarthritis.  

     

    Brand:
    Cayman
    SKU:23674 - 50 mg

    Available on backorder

  • Etofenamate is a non-steroidal anti-inflammatory drug (NSAID) and diethylene glycol ester form of flufenamic acid (Item No. 21447) that has anti-inflammatory and analgesic activities.{41244,41245} It inhibits lipoxygenase isolated from guinea pig leukocytes (IC50 = 5.3 μM) and the production of prostaglandin E2 (PGE2; Item No. 14010) in stimulated rat peritoneal macrophages.{41245} In vivo, etofenamate reduces acetic acid-induced vascular permeability in mice and UV-induced erythema in guinea pigs in a dose-dependent manner at doses ranging from 40-320 and 5-20 mg/kg, respectively.{41244} Etofenamate (40 mg/kg per day for 21 days) inhibits inflammation in a rat model of adjuvant-induced arthritis. It also decreases the pain response in a silver nitrate-induced rat model of arthritis and the acetic acid-induced writhing test in mice, indicating analgesic activity. Formulations containing etofenamate have been used in the treatment of osteoarthritis.  

     

    Brand:
    Cayman
    SKU:23674 - 500 mg

    Available on backorder

  • Etofenamate-d4 is intended for use as an internal standard for the quantification of etofenamate (Item No. 23674) by GC- or LC-MS. Etofenamate is a non-steroidal anti-inflammatory drug (NSAID) and diethylene glycol ester form of flufenamic acid (Item No. 21447) that has anti-inflammatory and analgesic activities.{41244,41245} It inhibits lipoxygenase isolated from guinea pig leukocytes (IC50 = 5.3 μM) and the production of prostaglandin E2 (PGE2; Item No. 14010) in stimulated rat peritoneal macrophages.{41245} In vivo, etofenamate reduces acetic acid-induced vascular permeability in mice and UV-induced erythema in guinea pigs in a dose-dependent manner at doses ranging from 40-320 and 5-20 mg/kg, respectively.{41244} Etofenamate (40 mg/kg per day for 21 days) inhibits inflammation in a rat model of adjuvant-induced arthritis. It also decreases the pain response in a silver nitrate-induced rat model of arthritis and the acetic acid-induced writhing test in mice, indicating analgesic activity. Formulations containing etofenamate have been used in the treatment of osteoarthritis.  

     

    Brand:
    Cayman
    SKU:30745 - 5 mg

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  • Etofenprox is a non-ester pyrethroid insecticide.{42441} It induces toxicity in the housefly M. domestica (LD50 = 23 ng/fly). Etofenprox (0.005-0.02%) induces 100% mortality in green leafhopper adults and brown planthopper and white-backed planthopper nymphs on rice plants within 24 hours of application.{42442} It is toxic to the aquatic invertebrate D. magna (EC50 = 1.2 μg a.s./L) and the fish O. mykiss (LC50 = 2.7 μg a.s./L) but not rats (LD50 = >2,000 mg/kg).{42443} Formulations containing etofenprox have been used in the control of agricultural pests.  

     

    Brand:
    Cayman
    SKU:25785 - 100 mg

    Available on backorder

  • Etofenprox is a non-ester pyrethroid insecticide.{42441} It induces toxicity in the housefly M. domestica (LD50 = 23 ng/fly). Etofenprox (0.005-0.02%) induces 100% mortality in green leafhopper adults and brown planthopper and white-backed planthopper nymphs on rice plants within 24 hours of application.{42442} It is toxic to the aquatic invertebrate D. magna (EC50 = 1.2 μg a.s./L) and the fish O. mykiss (LC50 = 2.7 μg a.s./L) but not rats (LD50 = >2,000 mg/kg).{42443} Formulations containing etofenprox have been used in the control of agricultural pests.  

     

    Brand:
    Cayman
    SKU:25785 - 25 mg

    Available on backorder

  • Etofenprox is a non-ester pyrethroid insecticide.{42441} It induces toxicity in the housefly M. domestica (LD50 = 23 ng/fly). Etofenprox (0.005-0.02%) induces 100% mortality in green leafhopper adults and brown planthopper and white-backed planthopper nymphs on rice plants within 24 hours of application.{42442} It is toxic to the aquatic invertebrate D. magna (EC50 = 1.2 μg a.s./L) and the fish O. mykiss (LC50 = 2.7 μg a.s./L) but not rats (LD50 = >2,000 mg/kg).{42443} Formulations containing etofenprox have been used in the control of agricultural pests.  

     

    Brand:
    Cayman
    SKU:25785 - 50 mg

    Available on backorder