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Terminally misfolded proteins, recognized by chaperones on the endoplasmic reticulum (ER), are transported to depots for ubiquitination and proteasomal degradation by the ER-associated protein degradation (ERAD) pathway. Eeyarestatin 1 is an inhibitor of the ERAD pathway, blocking the degradation of misfolded proteins at a dose of 8 µM.{15691} It associates with the p97-associated deubiquitinating complex in cells, preventing deubiquitination of substrates by ataxin-3.{27313,27314} Eeyarestatin 1, at 4 µM, interferes with both retrograde and anterograde trafficking of proteins, including certain toxins, and potentially, viruses.{27315}
Brand:CaymanSKU:10012609 - 10 mgAvailable on backorder
Terminally misfolded proteins, recognized by chaperones on the endoplasmic reticulum (ER), are transported to depots for ubiquitination and proteasomal degradation by the ER-associated protein degradation (ERAD) pathway. Eeyarestatin 1 is an inhibitor of the ERAD pathway, blocking the degradation of misfolded proteins at a dose of 8 µM.{15691} It associates with the p97-associated deubiquitinating complex in cells, preventing deubiquitination of substrates by ataxin-3.{27313,27314} Eeyarestatin 1, at 4 µM, interferes with both retrograde and anterograde trafficking of proteins, including certain toxins, and potentially, viruses.{27315}
Brand:CaymanSKU:10012609 - 25 mgAvailable on backorder
Terminally misfolded proteins, recognized by chaperones on the endoplasmic reticulum (ER), are transported to depots for ubiquitination and proteasomal degradation by the ER-associated protein degradation (ERAD) pathway. Eeyarestatin 1 is an inhibitor of the ERAD pathway, blocking the degradation of misfolded proteins at a dose of 8 µM.{15691} It associates with the p97-associated deubiquitinating complex in cells, preventing deubiquitination of substrates by ataxin-3.{27313,27314} Eeyarestatin 1, at 4 µM, interferes with both retrograde and anterograde trafficking of proteins, including certain toxins, and potentially, viruses.{27315}
Brand:CaymanSKU:10012609 - 5 mgAvailable on backorder
Efaproxiral is an allosteric hemoglobin (Hb) modifier that reduces the affinity of Hb for oxygen, increasing the diffusion of oxygen from blood to tissue.{51161} In isolated human whole blood, efaproxiral (1.75 mM) increases the partial pressure of oxygen at which Hb is 50% saturated (p50) from 26.75 to 38.63 mm Hg and decreases the percent oxyhemoglobin (Hb-O2) saturation from 48 to 33.8% at a partial oxygen pressure (pO2) of 26 mm Hg. Efaproxiral (150 mg/kg) increases tumor pO2 from 5.2 to 13.1 mm Hg 30 minutes after administration in a RIF-1 mouse fibrosarcoma flank tumor model.{51162} Efaproxiral (100 μM) enhances radiation-induced cytotoxicity in EMT6 mouse breast cancer cells grown under hypoxic conditions and increases radiosensitization and inhibits tumor growth in a hypoxic Lewis lung tumor mouse model when administered at a dose of 100 mg/kg.{51163} It also increases the running capacity of normal mice and mice with left coronary artery (LCA) ligation-induced myocardial infarction (MI) when administered at a dose of 150 mg/kg.{51164}
Brand:CaymanSKU:28294 - 1 gAvailable on backorder
Efaproxiral is an allosteric hemoglobin (Hb) modifier that reduces the affinity of Hb for oxygen, increasing the diffusion of oxygen from blood to tissue.{51161} In isolated human whole blood, efaproxiral (1.75 mM) increases the partial pressure of oxygen at which Hb is 50% saturated (p50) from 26.75 to 38.63 mm Hg and decreases the percent oxyhemoglobin (Hb-O2) saturation from 48 to 33.8% at a partial oxygen pressure (pO2) of 26 mm Hg. Efaproxiral (150 mg/kg) increases tumor pO2 from 5.2 to 13.1 mm Hg 30 minutes after administration in a RIF-1 mouse fibrosarcoma flank tumor model.{51162} Efaproxiral (100 μM) enhances radiation-induced cytotoxicity in EMT6 mouse breast cancer cells grown under hypoxic conditions and increases radiosensitization and inhibits tumor growth in a hypoxic Lewis lung tumor mouse model when administered at a dose of 100 mg/kg.{51163} It also increases the running capacity of normal mice and mice with left coronary artery (LCA) ligation-induced myocardial infarction (MI) when administered at a dose of 150 mg/kg.{51164}
Brand:CaymanSKU:28294 - 100 mgAvailable on backorder
Efaproxiral is an allosteric hemoglobin (Hb) modifier that reduces the affinity of Hb for oxygen, increasing the diffusion of oxygen from blood to tissue.{51161} In isolated human whole blood, efaproxiral (1.75 mM) increases the partial pressure of oxygen at which Hb is 50% saturated (p50) from 26.75 to 38.63 mm Hg and decreases the percent oxyhemoglobin (Hb-O2) saturation from 48 to 33.8% at a partial oxygen pressure (pO2) of 26 mm Hg. Efaproxiral (150 mg/kg) increases tumor pO2 from 5.2 to 13.1 mm Hg 30 minutes after administration in a RIF-1 mouse fibrosarcoma flank tumor model.{51162} Efaproxiral (100 μM) enhances radiation-induced cytotoxicity in EMT6 mouse breast cancer cells grown under hypoxic conditions and increases radiosensitization and inhibits tumor growth in a hypoxic Lewis lung tumor mouse model when administered at a dose of 100 mg/kg.{51163} It also increases the running capacity of normal mice and mice with left coronary artery (LCA) ligation-induced myocardial infarction (MI) when administered at a dose of 150 mg/kg.{51164}
Brand:CaymanSKU:28294 - 250 mgAvailable on backorder
Efaproxiral is an allosteric hemoglobin (Hb) modifier that reduces the affinity of Hb for oxygen, increasing the diffusion of oxygen from blood to tissue.{51161} In isolated human whole blood, efaproxiral (1.75 mM) increases the partial pressure of oxygen at which Hb is 50% saturated (p50) from 26.75 to 38.63 mm Hg and decreases the percent oxyhemoglobin (Hb-O2) saturation from 48 to 33.8% at a partial oxygen pressure (pO2) of 26 mm Hg. Efaproxiral (150 mg/kg) increases tumor pO2 from 5.2 to 13.1 mm Hg 30 minutes after administration in a RIF-1 mouse fibrosarcoma flank tumor model.{51162} Efaproxiral (100 μM) enhances radiation-induced cytotoxicity in EMT6 mouse breast cancer cells grown under hypoxic conditions and increases radiosensitization and inhibits tumor growth in a hypoxic Lewis lung tumor mouse model when administered at a dose of 100 mg/kg.{51163} It also increases the running capacity of normal mice and mice with left coronary artery (LCA) ligation-induced myocardial infarction (MI) when administered at a dose of 150 mg/kg.{51164}
Brand:CaymanSKU:28294 - 500 mgAvailable on backorder
Efaroxan is an α2-adrenergic receptor (α2-AR; EC50s = 1 receptor antagonist.{52072} It binds to α2A-, α2B-, and α2C-ARs (Kis = 13, 38, and 1,820 nM, respectively) and selectively to I1 over I2 receptors (Kis = 52 and >10,000 nM, respectively). Efaroxan is an I3 agonist that binds to putative I3 receptors on human pancreatic islets of Langerhans and stimulates insulin secretion when used at a concentration of 100 μM.{52073} It also binds to rat RIN-5AH insulinoma cell membranes (IC50 = 32 nM) and stimulates insulin secretion when used at a concentration of 100 μM.{52074} Efaroxan (5 mg/kg) lowers basal blood glucose levels in mice.{52075} It also increases 3,4-dihydroxyphenylalanine (L-DOPA; Item No. 13248) synthesis in rat cortex and hippocampus by 77 and 57%, respectively, when administered at a dose of 10 mg/kg.{52076}
Brand:CaymanSKU:29008 - 10 mgAvailable on backorder
Efaroxan is an α2-adrenergic receptor (α2-AR; EC50s = 1 receptor antagonist.{52072} It binds to α2A-, α2B-, and α2C-ARs (Kis = 13, 38, and 1,820 nM, respectively) and selectively to I1 over I2 receptors (Kis = 52 and >10,000 nM, respectively). Efaroxan is an I3 agonist that binds to putative I3 receptors on human pancreatic islets of Langerhans and stimulates insulin secretion when used at a concentration of 100 μM.{52073} It also binds to rat RIN-5AH insulinoma cell membranes (IC50 = 32 nM) and stimulates insulin secretion when used at a concentration of 100 μM.{52074} Efaroxan (5 mg/kg) lowers basal blood glucose levels in mice.{52075} It also increases 3,4-dihydroxyphenylalanine (L-DOPA; Item No. 13248) synthesis in rat cortex and hippocampus by 77 and 57%, respectively, when administered at a dose of 10 mg/kg.{52076}
Brand:CaymanSKU:29008 - 25 mgAvailable on backorder
Efaroxan is an α2-adrenergic receptor (α2-AR; EC50s = 1 receptor antagonist.{52072} It binds to α2A-, α2B-, and α2C-ARs (Kis = 13, 38, and 1,820 nM, respectively) and selectively to I1 over I2 receptors (Kis = 52 and >10,000 nM, respectively). Efaroxan is an I3 agonist that binds to putative I3 receptors on human pancreatic islets of Langerhans and stimulates insulin secretion when used at a concentration of 100 μM.{52073} It also binds to rat RIN-5AH insulinoma cell membranes (IC50 = 32 nM) and stimulates insulin secretion when used at a concentration of 100 μM.{52074} Efaroxan (5 mg/kg) lowers basal blood glucose levels in mice.{52075} It also increases 3,4-dihydroxyphenylalanine (L-DOPA; Item No. 13248) synthesis in rat cortex and hippocampus by 77 and 57%, respectively, when administered at a dose of 10 mg/kg.{52076}
Brand:CaymanSKU:29008 - 50 mgAvailable on backorder
Efavirenz is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that binds to wild-type and mutant HIV-1 RTs (Kis = 2.93 and 3.85-56.5 nM, respectively).{42187} It inhibits wild-type and mutant HIV-1 viral replication in MT-4 human T lymphoid cells (IC95s = 1.5-1,500 nM). Efavirenz also prevents RNA plus-strand initiation with an IC50 value of 17 nM.{22819} In vivo, efavirenz reduces HIV-1 cDNA in spleen of HIV-1-challenged HIV-susceptible transgenic rats.{42188} Formulations containing efavirenz have been used in combination therapy for the treatment of HIV-1.{22821,22820}
Brand:CaymanSKU:- Efavirenz is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that binds to wild-type and mutant HIV-1 RTs (Kis = 2.93 and 3.85-56.5 nM, respectively).{42187} It inhibits wild-type and mutant HIV-1 viral replication in MT-4 human T lymphoid cells (IC95s = 1.5-1,500 nM). Efavirenz also prevents RNA plus-strand initiation with an IC50 value of 17 nM.{22819} In vivo, efavirenz reduces HIV-1 cDNA in spleen of HIV-1-challenged HIV-susceptible transgenic rats.{42188} Formulations containing efavirenz have been used in combination therapy for the treatment of HIV-1.{22821,22820}
Brand:CaymanSKU:- Efavirenz is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that binds to wild-type and mutant HIV-1 RTs (Kis = 2.93 and 3.85-56.5 nM, respectively).{42187} It inhibits wild-type and mutant HIV-1 viral replication in MT-4 human T lymphoid cells (IC95s = 1.5-1,500 nM). Efavirenz also prevents RNA plus-strand initiation with an IC50 value of 17 nM.{22819} In vivo, efavirenz reduces HIV-1 cDNA in spleen of HIV-1-challenged HIV-susceptible transgenic rats.{42188} Formulations containing efavirenz have been used in combination therapy for the treatment of HIV-1.{22821,22820}
Brand:CaymanSKU:- Efavirenz is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that binds to wild-type and mutant HIV-1 RTs (Kis = 2.93 and 3.85-56.5 nM, respectively).{42187} It inhibits wild-type and mutant HIV-1 viral replication in MT-4 human T lymphoid cells (IC95s = 1.5-1,500 nM). Efavirenz also prevents RNA plus-strand initiation with an IC50 value of 17 nM.{22819} In vivo, efavirenz reduces HIV-1 cDNA in spleen of HIV-1-challenged HIV-susceptible transgenic rats.{42188} Formulations containing efavirenz have been used in combination therapy for the treatment of HIV-1.{22821,22820}
Brand:CaymanSKU:-
Efferocytosis is a specialized form of phagocytosis in which macrophages and other phagocytic cells clear dead and dying cells to promote homeostasis, embryonic development, regulation of the immune system and the resolution of inflammation.{35342} Efficient clearance of cells is essential for the removal of the nearly 1 million cells per second undergoing apoptosis in a human adult.{35343} Efferocytic removal of apoptotic cells before they become necrotic and release their contents can prevent an immune response to these non-pathogenic antigens.
Brand:CaymanSKU:601770 - 1 eaAvailable on backorder
Efinaconazole is a broad-spectrum triazole antifungal agent with activity against Acremonium, Aspergillus, Candida, Cryptococcus, Epidermophyton, Fusarium, Microsporum, Paecilomyces, Pseudallescheria, Scopulariopsis, Trichophyton, and Trichosporon.{41490} It inhibits the growth of T. rubrum and T. mentagrophytes clinical isolates with MIC values ranging from ≤2.0 to 60 ng/ml and of C. albicans isolates with MIC values ranging from ≤0.5 to >250 ng/ml. Efinaconazole inhibits sterol 14α-demethylase, which arrests ergosterol (Item No. 19850) biosynthesis at the fungal membrane.{41491} It inhibits ergosterol biosynthesis in T. mentagrophytes and C. albicans with IC50 values of 7.0 and 0.40 ng/ml, respectfully. Topical formulations containing efinaconazole have been used for the treatment of onychomycosis.
Brand:CaymanSKU:23839 - 10 mgAvailable on backorder
Efinaconazole is a broad-spectrum triazole antifungal agent with activity against Acremonium, Aspergillus, Candida, Cryptococcus, Epidermophyton, Fusarium, Microsporum, Paecilomyces, Pseudallescheria, Scopulariopsis, Trichophyton, and Trichosporon.{41490} It inhibits the growth of T. rubrum and T. mentagrophytes clinical isolates with MIC values ranging from ≤2.0 to 60 ng/ml and of C. albicans isolates with MIC values ranging from ≤0.5 to >250 ng/ml. Efinaconazole inhibits sterol 14α-demethylase, which arrests ergosterol (Item No. 19850) biosynthesis at the fungal membrane.{41491} It inhibits ergosterol biosynthesis in T. mentagrophytes and C. albicans with IC50 values of 7.0 and 0.40 ng/ml, respectfully. Topical formulations containing efinaconazole have been used for the treatment of onychomycosis.
Brand:CaymanSKU:23839 - 100 mgAvailable on backorder
Efinaconazole is a broad-spectrum triazole antifungal agent with activity against Acremonium, Aspergillus, Candida, Cryptococcus, Epidermophyton, Fusarium, Microsporum, Paecilomyces, Pseudallescheria, Scopulariopsis, Trichophyton, and Trichosporon.{41490} It inhibits the growth of T. rubrum and T. mentagrophytes clinical isolates with MIC values ranging from ≤2.0 to 60 ng/ml and of C. albicans isolates with MIC values ranging from ≤0.5 to >250 ng/ml. Efinaconazole inhibits sterol 14α-demethylase, which arrests ergosterol (Item No. 19850) biosynthesis at the fungal membrane.{41491} It inhibits ergosterol biosynthesis in T. mentagrophytes and C. albicans with IC50 values of 7.0 and 0.40 ng/ml, respectfully. Topical formulations containing efinaconazole have been used for the treatment of onychomycosis.
Brand:CaymanSKU:23839 - 25 mgAvailable on backorder
Efinaconazole is a broad-spectrum triazole antifungal agent with activity against Acremonium, Aspergillus, Candida, Cryptococcus, Epidermophyton, Fusarium, Microsporum, Paecilomyces, Pseudallescheria, Scopulariopsis, Trichophyton, and Trichosporon.{41490} It inhibits the growth of T. rubrum and T. mentagrophytes clinical isolates with MIC values ranging from ≤2.0 to 60 ng/ml and of C. albicans isolates with MIC values ranging from ≤0.5 to >250 ng/ml. Efinaconazole inhibits sterol 14α-demethylase, which arrests ergosterol (Item No. 19850) biosynthesis at the fungal membrane.{41491} It inhibits ergosterol biosynthesis in T. mentagrophytes and C. albicans with IC50 values of 7.0 and 0.40 ng/ml, respectfully. Topical formulations containing efinaconazole have been used for the treatment of onychomycosis.
Brand:CaymanSKU:23839 - 5 mgAvailable on backorder
eFT508 is a potent inhibitor of MAPK interacting protein kinases (MNK) 1 and 2 (IC50s = 50 value of <50 nM in a cellular signaling assay. eFT508 has a half-life of 5.3 hours in rats.
Brand:CaymanSKU:21957 -Out of stock
eFT508 is a potent inhibitor of MAPK interacting protein kinases (MNK) 1 and 2 (IC50s = 50 value of <50 nM in a cellular signaling assay. eFT508 has a half-life of 5.3 hours in rats.
Brand:CaymanSKU:21957 -Out of stock
eFT508 is a potent inhibitor of MAPK interacting protein kinases (MNK) 1 and 2 (IC50s = 50 value of <50 nM in a cellular signaling assay. eFT508 has a half-life of 5.3 hours in rats.
Brand:CaymanSKU:21957 -Out of stock
eFT508 is a potent inhibitor of MAPK interacting protein kinases (MNK) 1 and 2 (IC50s = 50 value of <50 nM in a cellular signaling assay. eFT508 has a half-life of 5.3 hours in rats.
Brand:CaymanSKU:21957 -Out of stock
The kinesin-like spindle protein Eg5, also known as KSP and Kif11, is a motor protein that is essential for establishing a bipolar spindle during mitosis.{22151} Eg5-I is a potent inhibitor of Eg5, both in vitro and in cells (IC50s = 127 and 190 nM, respectively).{26966} It is an analog of S-trityl-L-cysteine (STLC), but is more potent and has better solubility than STLC. Eg5-I blocks bipolar spindle formation and inhibits the growth of cancer cells, with an average GI50 value of 360 nM against a broad panel of tumor cells (GI50 range = 10 nM to 3 µM).{26966} It ranges from 140- to 1200-fold more potent against cancer cells than monastrol (Item No. 15044), which also acts by inhibiting Eg5.{22151,26966}
Brand:CaymanSKU:-Out of stock
The kinesin-like spindle protein Eg5, also known as KSP and Kif11, is a motor protein that is essential for establishing a bipolar spindle during mitosis.{22151} Eg5-I is a potent inhibitor of Eg5, both in vitro and in cells (IC50s = 127 and 190 nM, respectively).{26966} It is an analog of S-trityl-L-cysteine (STLC), but is more potent and has better solubility than STLC. Eg5-I blocks bipolar spindle formation and inhibits the growth of cancer cells, with an average GI50 value of 360 nM against a broad panel of tumor cells (GI50 range = 10 nM to 3 µM).{26966} It ranges from 140- to 1200-fold more potent against cancer cells than monastrol (Item No. 15044), which also acts by inhibiting Eg5.{22151,26966}
Brand:CaymanSKU:-Out of stock
The kinesin-like spindle protein Eg5, also known as KSP and Kif11, is a motor protein that is essential for establishing a bipolar spindle during mitosis.{22151} Eg5-I is a potent inhibitor of Eg5, both in vitro and in cells (IC50s = 127 and 190 nM, respectively).{26966} It is an analog of S-trityl-L-cysteine (STLC), but is more potent and has better solubility than STLC. Eg5-I blocks bipolar spindle formation and inhibits the growth of cancer cells, with an average GI50 value of 360 nM against a broad panel of tumor cells (GI50 range = 10 nM to 3 µM).{26966} It ranges from 140- to 1200-fold more potent against cancer cells than monastrol (Item No. 15044), which also acts by inhibiting Eg5.{22151,26966}
Brand:CaymanSKU:-Out of stock
EGA is an inhibitor of endosomal trafficking.{46123} It increases accumulation of fluorescently labeled EGF in early endosomes in HeLa cells when used at a concentration of 20 μM. EGA inhibits cell death induced by anthrax lethal toxin in RAW264.7 cells (IC50 = 1.7 μM) as well as by additional acid-dependent bacterial toxins, including diphtheria toxin, P. aeruginosa ExoA, and H. ducreyi cytolethal distending toxin (Hd-CDT), in various cell types. It also inhibits infection of Vero and HeLa cells by the low pH-dependent lymphocytic choriomeningitis (LCMV; Armstrong strain) and influenza A/WSN/33 viruses, respectively.
Brand:CaymanSKU:21882 -Out of stock
EGA is an inhibitor of endosomal trafficking.{46123} It increases accumulation of fluorescently labeled EGF in early endosomes in HeLa cells when used at a concentration of 20 μM. EGA inhibits cell death induced by anthrax lethal toxin in RAW264.7 cells (IC50 = 1.7 μM) as well as by additional acid-dependent bacterial toxins, including diphtheria toxin, P. aeruginosa ExoA, and H. ducreyi cytolethal distending toxin (Hd-CDT), in various cell types. It also inhibits infection of Vero and HeLa cells by the low pH-dependent lymphocytic choriomeningitis (LCMV; Armstrong strain) and influenza A/WSN/33 viruses, respectively.
Brand:CaymanSKU:21882 -Out of stock
EGA is an inhibitor of endosomal trafficking.{46123} It increases accumulation of fluorescently labeled EGF in early endosomes in HeLa cells when used at a concentration of 20 μM. EGA inhibits cell death induced by anthrax lethal toxin in RAW264.7 cells (IC50 = 1.7 μM) as well as by additional acid-dependent bacterial toxins, including diphtheria toxin, P. aeruginosa ExoA, and H. ducreyi cytolethal distending toxin (Hd-CDT), in various cell types. It also inhibits infection of Vero and HeLa cells by the low pH-dependent lymphocytic choriomeningitis (LCMV; Armstrong strain) and influenza A/WSN/33 viruses, respectively.
Brand:CaymanSKU:21882 -Out of stock
EGA is an inhibitor of endosomal trafficking.{46123} It increases accumulation of fluorescently labeled EGF in early endosomes in HeLa cells when used at a concentration of 20 μM. EGA inhibits cell death induced by anthrax lethal toxin in RAW264.7 cells (IC50 = 1.7 μM) as well as by additional acid-dependent bacterial toxins, including diphtheria toxin, P. aeruginosa ExoA, and H. ducreyi cytolethal distending toxin (Hd-CDT), in various cell types. It also inhibits infection of Vero and HeLa cells by the low pH-dependent lymphocytic choriomeningitis (LCMV; Armstrong strain) and influenza A/WSN/33 viruses, respectively.
Brand:CaymanSKU:21882 -Out of stock
EGCG octaacetate is a prodrug form of (–)-epigallocatechin gallate (EGCG; Item No. 70935).{59063} It is cleaved by intracellular esterases to form EGCG. EGCG octaacetate (50 µM) reduces proteasome activity in MDA-MB-231 breast cancer cells extracts.{59064} It induces apoptosis in, and inhibits proliferation of, MDA-MB-231 cells when used at the same concentration. Dietary administration of EGCG octaacetate (0.085%) decreases colonic IL-6, IL-1β, and TNF-α levels, as well as reduces colonic shortening, tissue damage, and inflammatory cell infiltration in a mouse model of colitis induced by dextran sulfate sodium (DSS; Item No. 23250).{59065}
Brand:CaymanSKU:31144 - 10 mgAvailable on backorder
EGCG octaacetate is a prodrug form of (–)-epigallocatechin gallate (EGCG; Item No. 70935).{59063} It is cleaved by intracellular esterases to form EGCG. EGCG octaacetate (50 µM) reduces proteasome activity in MDA-MB-231 breast cancer cells extracts.{59064} It induces apoptosis in, and inhibits proliferation of, MDA-MB-231 cells when used at the same concentration. Dietary administration of EGCG octaacetate (0.085%) decreases colonic IL-6, IL-1β, and TNF-α levels, as well as reduces colonic shortening, tissue damage, and inflammatory cell infiltration in a mouse model of colitis induced by dextran sulfate sodium (DSS; Item No. 23250).{59065}
Brand:CaymanSKU:31144 - 25 mgAvailable on backorder
EGCG octaacetate is a prodrug form of (–)-epigallocatechin gallate (EGCG; Item No. 70935).{59063} It is cleaved by intracellular esterases to form EGCG. EGCG octaacetate (50 µM) reduces proteasome activity in MDA-MB-231 breast cancer cells extracts.{59064} It induces apoptosis in, and inhibits proliferation of, MDA-MB-231 cells when used at the same concentration. Dietary administration of EGCG octaacetate (0.085%) decreases colonic IL-6, IL-1β, and TNF-α levels, as well as reduces colonic shortening, tissue damage, and inflammatory cell infiltration in a mouse model of colitis induced by dextran sulfate sodium (DSS; Item No. 23250).{59065}
Brand:CaymanSKU:31144 - 50 mgAvailable on backorder
Epidermal growth factor receptor (EGFR), also known as HER1 and ERBB1, is a cell surface receptor and member of the EGF family of receptor tyrosine kinases with roles in cell proliferation, differentiation, and survival.{54146,54144} It is a transmembrane receptor composed of an intracellular tyrosine kinase domain, a transmembrane lipophilic segment, and an extracellular domain that is expressed in epithelial, mesenchymal, and neuronal tissues.{54146,54144,54147} Under unstimulated conditions, EGFR is an auto-inhibited monomer in the plasma membrane.{54146} Upon canonical ligand binding, EGFR undergoes homodimerization or heterodimerization with HER2, HER3, or HER4, which induces a conformational change in the cytoplasmic domain that facilitates autophosphorylation and intracellular signaling. EGFR contains five C-terminal autophosphorylation sites, tyrosine 1068 (Tyr1068), Tyr1148, Tyr1173, Tyr1086, and Tyr992.{60064} EGFR autophosphorylation at Tyr1173 (phospho-Tyr1173) leads to interaction with phospholipase Cγ (PLCγ) and Shc, which have roles in activating the MAPK signaling pathway. Increased levels of EGFR (phospho-Tyr1173) are associated with poor progression-free survival in patients with non-small cell lung cancer (NSCLC). Levels of EGFR (phospho-Tyr1173) are increased in, and positively correlate with activation of MAPK signaling and cytokine production in, bronchial epithelial biopsies from healthy individuals exposed to diesel exhaust.{60065} Cayman’s EGFR (Phospho-Tyr1173) Rabbit Monoclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications.
Brand:CaymanSKU:32219 - 100 µlAvailable on backorder
Immunogen: Peptide corresponding to human EGFR (phospho-Tyr1173) • Host: Rabbit • Species Reactivity: (+) Human • Cross Reactivity: (+) EGFR (phospho-Tyr1173); (-) EGFR without phosphorylation at Tyr1173 • Applications: IHC, WB
Brand:CaymanSKU:32219- 100 µlAvailable on backorder
Immunogen: Peptide corresponding to human EGFR (phospho-Tyr1173) • Host: Rabbit • Species Reactivity: (+) Human • Cross Reactivity: (+) EGFR (phospho-Tyr1173); (-) EGFR without phosphorylation at Tyr1173 • Applications: IHC, WB
Brand:CaymanSKU:32219- 100 µl
EGFR inhibitor is a cell permeable, 4,6-disubstituted pyrimidine compound that selectively inhibits the EGFR kinase with an IC50 value of 21 nM in vitro and blocks receptor autophosphorylation in cells.{25289} It can also inhibit the L858R and L861Q EGFR mutants (IC50s = 63 and 4 nM, respectively) yet displays strong selectivity for EGFR against a panel of 55 recombinant kinases (IC50s > 10 μM).{25289} Whereas overactivity of EGFR tyrosine kinases has been associated with a number of cancers, inhibition of EGFR has been shown to induce apoptosis by downregulating antiapoptotic proteins such as survivin and upregulating proapoptotic proteins such as Bim.{25291,25290}
Brand:CaymanSKU:- EGFR inhibitor is a cell permeable, 4,6-disubstituted pyrimidine compound that selectively inhibits the EGFR kinase with an IC50 value of 21 nM in vitro and blocks receptor autophosphorylation in cells.{25289} It can also inhibit the L858R and L861Q EGFR mutants (IC50s = 63 and 4 nM, respectively) yet displays strong selectivity for EGFR against a panel of 55 recombinant kinases (IC50s > 10 μM).{25289} Whereas overactivity of EGFR tyrosine kinases has been associated with a number of cancers, inhibition of EGFR has been shown to induce apoptosis by downregulating antiapoptotic proteins such as survivin and upregulating proapoptotic proteins such as Bim.{25291,25290}
Brand:CaymanSKU:- EGFR inhibitor is a cell permeable, 4,6-disubstituted pyrimidine compound that selectively inhibits the EGFR kinase with an IC50 value of 21 nM in vitro and blocks receptor autophosphorylation in cells.{25289} It can also inhibit the L858R and L861Q EGFR mutants (IC50s = 63 and 4 nM, respectively) yet displays strong selectivity for EGFR against a panel of 55 recombinant kinases (IC50s > 10 μM).{25289} Whereas overactivity of EGFR tyrosine kinases has been associated with a number of cancers, inhibition of EGFR has been shown to induce apoptosis by downregulating antiapoptotic proteins such as survivin and upregulating proapoptotic proteins such as Bim.{25291,25290}
Brand:CaymanSKU:-
EGFR/ErbB2 inhibitor is a cell-permeable inhibitor of EGFR and c-ErbB2 (HER2, Neu; IC50s = 20 and 79 nM, respectively).{28556} It inhibits the proliferation of cancer cells overexpressing either c-ErbB2 or EGFR (IC50s = 2.3-2.5 µM).{28556} EGFR/ErbB2 inhibitor displays a high level of selectivity for these kinases.{28555}
Brand:CaymanSKU:-Available on backorder
EGFR/ErbB2 inhibitor is a cell-permeable inhibitor of EGFR and c-ErbB2 (HER2, Neu; IC50s = 20 and 79 nM, respectively).{28556} It inhibits the proliferation of cancer cells overexpressing either c-ErbB2 or EGFR (IC50s = 2.3-2.5 µM).{28556} EGFR/ErbB2 inhibitor displays a high level of selectivity for these kinases.{28555}
Brand:CaymanSKU:-Available on backorder
Type 4 cyclic nucleotide phosphodiesterase (PDE4) selectively inactivates the second messenger cAMP by hydrolyzing the phosphodiester bond, producing AMP. PDE4 has been reported to play a key regulatory role in Hedgehog signaling downstream of smoothened and, thus, represents a potential therapeutic target for Hedgehog-dependent cancers.{28683} Eggmanone is a selective inhibitor of PDE4 (IC50 = 72 nM) that antagonizes the Hedgehog signaling pathway.{28683} It demonstrates 40- to 50-fold lower potency at PDE3, PDE10, and PDE11 (IC50s = 3, 3.05, and 4.08 µM, respectively).{28683} Inhibition of PDE4 activity via eggmanone was shown to activate localized protein kinase A signaling, which, in turn, regulates Gli processing and translocation.{28683}
Brand:CaymanSKU:-Available on backorder
Type 4 cyclic nucleotide phosphodiesterase (PDE4) selectively inactivates the second messenger cAMP by hydrolyzing the phosphodiester bond, producing AMP. PDE4 has been reported to play a key regulatory role in Hedgehog signaling downstream of smoothened and, thus, represents a potential therapeutic target for Hedgehog-dependent cancers.{28683} Eggmanone is a selective inhibitor of PDE4 (IC50 = 72 nM) that antagonizes the Hedgehog signaling pathway.{28683} It demonstrates 40- to 50-fold lower potency at PDE3, PDE10, and PDE11 (IC50s = 3, 3.05, and 4.08 µM, respectively).{28683} Inhibition of PDE4 activity via eggmanone was shown to activate localized protein kinase A signaling, which, in turn, regulates Gli processing and translocation.{28683}
Brand:CaymanSKU:-Available on backorder
Type 4 cyclic nucleotide phosphodiesterase (PDE4) selectively inactivates the second messenger cAMP by hydrolyzing the phosphodiester bond, producing AMP. PDE4 has been reported to play a key regulatory role in Hedgehog signaling downstream of smoothened and, thus, represents a potential therapeutic target for Hedgehog-dependent cancers.{28683} Eggmanone is a selective inhibitor of PDE4 (IC50 = 72 nM) that antagonizes the Hedgehog signaling pathway.{28683} It demonstrates 40- to 50-fold lower potency at PDE3, PDE10, and PDE11 (IC50s = 3, 3.05, and 4.08 µM, respectively).{28683} Inhibition of PDE4 activity via eggmanone was shown to activate localized protein kinase A signaling, which, in turn, regulates Gli processing and translocation.{28683}
Brand:CaymanSKU:-Available on backorder
EGT-1442 is a potent, selective sodium glucose co-transporter 2 (SGLT2) inhibitor with IC50 values of 5.6 µM and 2 nM for human SGLT1 and SGLT2, respectively.{33505} It produces a stable urinary excretion of glucose in rats and dogs with ED50 values of 0.38 and 0.09 mg/kg, respectively, and reduces HbA(1c) and blood glucose in db/db mice in a concentration dependent manner.
Brand:CaymanSKU:21359 -Out of stock
EGT-1442 is a potent, selective sodium glucose co-transporter 2 (SGLT2) inhibitor with IC50 values of 5.6 µM and 2 nM for human SGLT1 and SGLT2, respectively.{33505} It produces a stable urinary excretion of glucose in rats and dogs with ED50 values of 0.38 and 0.09 mg/kg, respectively, and reduces HbA(1c) and blood glucose in db/db mice in a concentration dependent manner.
Brand:CaymanSKU:21359 -Out of stock
EGT-1442 is a potent, selective sodium glucose co-transporter 2 (SGLT2) inhibitor with IC50 values of 5.6 µM and 2 nM for human SGLT1 and SGLT2, respectively.{33505} It produces a stable urinary excretion of glucose in rats and dogs with ED50 values of 0.38 and 0.09 mg/kg, respectively, and reduces HbA(1c) and blood glucose in db/db mice in a concentration dependent manner.
Brand:CaymanSKU:21359 -Out of stock
EGT-1442 is a potent, selective sodium glucose co-transporter 2 (SGLT2) inhibitor with IC50 values of 5.6 µM and 2 nM for human SGLT1 and SGLT2, respectively.{33505} It produces a stable urinary excretion of glucose in rats and dogs with ED50 values of 0.38 and 0.09 mg/kg, respectively, and reduces HbA(1c) and blood glucose in db/db mice in a concentration dependent manner.
Brand:CaymanSKU:21359 -Out of stock
EGTA AM is a cell-permeant acetoxymethyl ester of the calcium chelator EGTA. As EGTA AM enters cells, it is hydrolyzed by intracellular esterases to produce EGTA. EGTA AM is used to evaluate the role of intracellular calcium changes in cell signaling.{31948,31949,31950}
Brand:CaymanSKU:20401 -Available on backorder
EHNA is a reversible adenosine deaminase inhibitor (IC50 = 1.2 μM in human red blood cells) that also selectively inhibits the cGMP-specific phosphodiesterase (PDE2) (IC50s = 0.8 and 2 μM from human and porcine myocardium, respectively, 3.5 μM in rat hepatocyte, and 5.5 μM in human platelet).{20010,20014} Comparatively, EHNA is much less potent at inhibiting PDE1, PDE3, or PDE4 (IC50s > 100 μM).{20010} EHNA has been used to evaluate cardioprotective and neuroprotective effects during ischemia, to study the role of cAMP/cGMP signaling, and to maintain pluripotency/prevent differentiation of human embryonic stem cells.{20013,20012,20011}
Brand:CaymanSKU:- EHNA is a reversible adenosine deaminase inhibitor (IC50 = 1.2 μM in human red blood cells) that also selectively inhibits the cGMP-specific phosphodiesterase (PDE2) (IC50s = 0.8 and 2 μM from human and porcine myocardium, respectively, 3.5 μM in rat hepatocyte, and 5.5 μM in human platelet).{20010,20014} Comparatively, EHNA is much less potent at inhibiting PDE1, PDE3, or PDE4 (IC50s > 100 μM).{20010} EHNA has been used to evaluate cardioprotective and neuroprotective effects during ischemia, to study the role of cAMP/cGMP signaling, and to maintain pluripotency/prevent differentiation of human embryonic stem cells.{20013,20012,20011}
Brand:CaymanSKU:- EHNA is a reversible adenosine deaminase inhibitor (IC50 = 1.2 μM in human red blood cells) that also selectively inhibits the cGMP-specific phosphodiesterase (PDE2) (IC50s = 0.8 and 2 μM from human and porcine myocardium, respectively, 3.5 μM in rat hepatocyte, and 5.5 μM in human platelet).{20010,20014} Comparatively, EHNA is much less potent at inhibiting PDE1, PDE3, or PDE4 (IC50s > 100 μM).{20010} EHNA has been used to evaluate cardioprotective and neuroprotective effects during ischemia, to study the role of cAMP/cGMP signaling, and to maintain pluripotency/prevent differentiation of human embryonic stem cells.{20013,20012,20011}
Brand:CaymanSKU:-
EHop-016 is an inhibitor of the small Rho GTPases Rac1 and Rac3.{38132} It inhibits Rac1 activity in MDA-MB-435 breast cancer cells with an IC50 value of 1.1 μM in a Rac1 activation assay.{38131} At a concentration of 1 μM, EHop-016 inhibits 58% of Rac3 activity, and it inhibits Cdc42 activity but only at higher concentrations (5-10 μM). It also increases Rho GTPase RhoA activity ~1.3-fold at concentrations greater than 2 μM. EHop-016 (2-4 μM) inhibits Rac-regulated functions in MDA-MB-435 cells, including lamellipodia formation and serine/threonine p21-activated kinase 1 (PAK1)-mediated cell migration. In a nude mouse model of breast cancer metastasis, EHop-016 (25 mg/kg) significantly lowers mammary fat pad tumor growth, metastasis, and angiogenesis.{38134} It also inhibits mutant receptor tyrosine kinase (KIT)-induced growth in systemic mastocytosis and acute myeloid leukemia (AML) cells (≥2.5 μM).{38133}
Brand:CaymanSKU:21557 -Out of stock
EHop-016 is an inhibitor of the small Rho GTPases Rac1 and Rac3.{38132} It inhibits Rac1 activity in MDA-MB-435 breast cancer cells with an IC50 value of 1.1 μM in a Rac1 activation assay.{38131} At a concentration of 1 μM, EHop-016 inhibits 58% of Rac3 activity, and it inhibits Cdc42 activity but only at higher concentrations (5-10 μM). It also increases Rho GTPase RhoA activity ~1.3-fold at concentrations greater than 2 μM. EHop-016 (2-4 μM) inhibits Rac-regulated functions in MDA-MB-435 cells, including lamellipodia formation and serine/threonine p21-activated kinase 1 (PAK1)-mediated cell migration. In a nude mouse model of breast cancer metastasis, EHop-016 (25 mg/kg) significantly lowers mammary fat pad tumor growth, metastasis, and angiogenesis.{38134} It also inhibits mutant receptor tyrosine kinase (KIT)-induced growth in systemic mastocytosis and acute myeloid leukemia (AML) cells (≥2.5 μM).{38133}
Brand:CaymanSKU:21557 -Out of stock
EHop-016 is an inhibitor of the small Rho GTPases Rac1 and Rac3.{38132} It inhibits Rac1 activity in MDA-MB-435 breast cancer cells with an IC50 value of 1.1 μM in a Rac1 activation assay.{38131} At a concentration of 1 μM, EHop-016 inhibits 58% of Rac3 activity, and it inhibits Cdc42 activity but only at higher concentrations (5-10 μM). It also increases Rho GTPase RhoA activity ~1.3-fold at concentrations greater than 2 μM. EHop-016 (2-4 μM) inhibits Rac-regulated functions in MDA-MB-435 cells, including lamellipodia formation and serine/threonine p21-activated kinase 1 (PAK1)-mediated cell migration. In a nude mouse model of breast cancer metastasis, EHop-016 (25 mg/kg) significantly lowers mammary fat pad tumor growth, metastasis, and angiogenesis.{38134} It also inhibits mutant receptor tyrosine kinase (KIT)-induced growth in systemic mastocytosis and acute myeloid leukemia (AML) cells (≥2.5 μM).{38133}
Brand:CaymanSKU:21557 -Out of stock
EHop-016 is an inhibitor of the small Rho GTPases Rac1 and Rac3.{38132} It inhibits Rac1 activity in MDA-MB-435 breast cancer cells with an IC50 value of 1.1 μM in a Rac1 activation assay.{38131} At a concentration of 1 μM, EHop-016 inhibits 58% of Rac3 activity, and it inhibits Cdc42 activity but only at higher concentrations (5-10 μM). It also increases Rho GTPase RhoA activity ~1.3-fold at concentrations greater than 2 μM. EHop-016 (2-4 μM) inhibits Rac-regulated functions in MDA-MB-435 cells, including lamellipodia formation and serine/threonine p21-activated kinase 1 (PAK1)-mediated cell migration. In a nude mouse model of breast cancer metastasis, EHop-016 (25 mg/kg) significantly lowers mammary fat pad tumor growth, metastasis, and angiogenesis.{38134} It also inhibits mutant receptor tyrosine kinase (KIT)-induced growth in systemic mastocytosis and acute myeloid leukemia (AML) cells (≥2.5 μM).{38133}
Brand:CaymanSKU:21557 -Out of stock
EHT 1864 is an inhibitor of the Rac subfamily of Rho GTPases, that binds to Rac1, Rac1b, Rac2, and Rac3 with Kd values of 40, 50, 50, and 250 nM, respectively.{28453} It can reverse transformation of NIH 3T3 fibroblasts caused by constitutively activated Rac1, as well as Rac-dependent transformation caused by Tiam1 or Ras.{28453} EHT 1864 inhibits APP processing by γ-secretase, reducing Αβ40 and Αβ42 accumulation.{28454} It blocks breast cancer cell invasion in a collagen matrix assay and, at 10 µM, increases the size but decreases the density of dendritic spines of hippocampal neurons in culture.{28455,28456}
Brand:CaymanSKU:-Out of stock
EHT 1864 is an inhibitor of the Rac subfamily of Rho GTPases, that binds to Rac1, Rac1b, Rac2, and Rac3 with Kd values of 40, 50, 50, and 250 nM, respectively.{28453} It can reverse transformation of NIH 3T3 fibroblasts caused by constitutively activated Rac1, as well as Rac-dependent transformation caused by Tiam1 or Ras.{28453} EHT 1864 inhibits APP processing by γ-secretase, reducing Αβ40 and Αβ42 accumulation.{28454} It blocks breast cancer cell invasion in a collagen matrix assay and, at 10 µM, increases the size but decreases the density of dendritic spines of hippocampal neurons in culture.{28455,28456}
Brand:CaymanSKU:-Out of stock
EHT 1864 is an inhibitor of the Rac subfamily of Rho GTPases, that binds to Rac1, Rac1b, Rac2, and Rac3 with Kd values of 40, 50, 50, and 250 nM, respectively.{28453} It can reverse transformation of NIH 3T3 fibroblasts caused by constitutively activated Rac1, as well as Rac-dependent transformation caused by Tiam1 or Ras.{28453} EHT 1864 inhibits APP processing by γ-secretase, reducing Αβ40 and Αβ42 accumulation.{28454} It blocks breast cancer cell invasion in a collagen matrix assay and, at 10 µM, increases the size but decreases the density of dendritic spines of hippocampal neurons in culture.{28455,28456}
Brand:CaymanSKU:-Out of stock
EHT 1864 is an inhibitor of the Rac subfamily of Rho GTPases, that binds to Rac1, Rac1b, Rac2, and Rac3 with Kd values of 40, 50, 50, and 250 nM, respectively.{28453} It can reverse transformation of NIH 3T3 fibroblasts caused by constitutively activated Rac1, as well as Rac-dependent transformation caused by Tiam1 or Ras.{28453} EHT 1864 inhibits APP processing by γ-secretase, reducing Αβ40 and Αβ42 accumulation.{28454} It blocks breast cancer cell invasion in a collagen matrix assay and, at 10 µM, increases the size but decreases the density of dendritic spines of hippocampal neurons in culture.{28455,28456}
Brand:CaymanSKU:-Out of stock
The lysine methyltransferase EZH2 (KMT6), part of polycomb repressive complex 2 (PRC2), catalyzes trimethylation of lysine 27 on histone H3 (H3K27) and is involved in proliferation and aggressive cell growth associated with neoplastic cells.{18930} EI1 is an EZH2 inhibitor that has activity against both wild-type and Y641F mutant EZH2 (IC50s = 15 and 13 nM, respectively).{30943} It displays 90-fold selectivity for EZH2 over EZH1 and >10,000-fold over other lysine methyltransferases. EI1 blocks cellular H3K27 methylation and activates PRC2-specific gene expression.{30943} Inhibition of EZH2 by EI1 in diffused large B cell lymphoma cells carrying Y641 mutations results in decreased proliferation, cell cycle arrest, and apoptosis.{30943}
Brand:CaymanSKU:-Available on backorder
The lysine methyltransferase EZH2 (KMT6), part of polycomb repressive complex 2 (PRC2), catalyzes trimethylation of lysine 27 on histone H3 (H3K27) and is involved in proliferation and aggressive cell growth associated with neoplastic cells.{18930} EI1 is an EZH2 inhibitor that has activity against both wild-type and Y641F mutant EZH2 (IC50s = 15 and 13 nM, respectively).{30943} It displays 90-fold selectivity for EZH2 over EZH1 and >10,000-fold over other lysine methyltransferases. EI1 blocks cellular H3K27 methylation and activates PRC2-specific gene expression.{30943} Inhibition of EZH2 by EI1 in diffused large B cell lymphoma cells carrying Y641 mutations results in decreased proliferation, cell cycle arrest, and apoptosis.{30943}
Brand:CaymanSKU:-Available on backorder
The lysine methyltransferase EZH2 (KMT6), part of polycomb repressive complex 2 (PRC2), catalyzes trimethylation of lysine 27 on histone H3 (H3K27) and is involved in proliferation and aggressive cell growth associated with neoplastic cells.{18930} EI1 is an EZH2 inhibitor that has activity against both wild-type and Y641F mutant EZH2 (IC50s = 15 and 13 nM, respectively).{30943} It displays 90-fold selectivity for EZH2 over EZH1 and >10,000-fold over other lysine methyltransferases. EI1 blocks cellular H3K27 methylation and activates PRC2-specific gene expression.{30943} Inhibition of EZH2 by EI1 in diffused large B cell lymphoma cells carrying Y641 mutations results in decreased proliferation, cell cycle arrest, and apoptosis.{30943}
Brand:CaymanSKU:-Available on backorder
EPA is an ω-3 fatty acid abundantly available in marine organisms. It is oxygenated by COX-1 and COX-2 at rates of about 5% and 30%, respectively, compared to arachidonic acid.{16250} EPA has been shown to offer protection against coronary heart disease, thrombosis, ischemic brain injury, scaly dermatitis, and some inflammatory diseases.{32,208}
Brand:CaymanSKU:90110 - 100 mgAvailable on backorder
EPA is an ω-3 fatty acid abundantly available in marine organisms. It is oxygenated by COX-1 and COX-2 at rates of about 5% and 30%, respectively, compared to arachidonic acid.{16250} EPA has been shown to offer protection against coronary heart disease, thrombosis, ischemic brain injury, scaly dermatitis, and some inflammatory diseases.{32,208}
Brand:CaymanSKU:90110 - 250 mgAvailable on backorder
EPA is an ω-3 fatty acid abundantly available in marine organisms. It is oxygenated by COX-1 and COX-2 at rates of about 5% and 30%, respectively, compared to arachidonic acid.{16250} EPA has been shown to offer protection against coronary heart disease, thrombosis, ischemic brain injury, scaly dermatitis, and some inflammatory diseases.{32,208}
Brand:CaymanSKU:90110 - 50 mgAvailable on backorder
EPA is an ω-3 fatty acid abundantly available in marine organisms. It is oxygenated by COX-1 and COX-2 at rates of about 5% and 30%, respectively, compared to arachidonic acid.{16250} EPA has been shown to offer protection against coronary heart disease, thrombosis, ischemic brain injury, scaly dermatitis, and some inflammatory diseases.{32,208}
Brand:CaymanSKU:90110 - 500 mgAvailable on backorder
EPA is an ω-3 fatty acid abundantly available in marine organisms.{48419} It is oxygenated by COX-1 and COX-2 at rates of about 5% and 30%, respectively, compared to arachidonic acid.{16250} EPA has been shown to offer protection against coronary heart disease, thrombosis, ischemic brain injury, scaly dermatitis, and some inflammatory diseases.{32,208} Eicosapentaenoic acid (peroxide free) contains the antioxidant BHT (Item No. 89910). BHT-free eicosapentaenoic acid (Item Nos. 90110 | 21908) is also available.
Brand:CaymanSKU:90110.1 - 10 mgAvailable on backorder
EPA is an ω-3 fatty acid abundantly available in marine organisms.{48419} It is oxygenated by COX-1 and COX-2 at rates of about 5% and 30%, respectively, compared to arachidonic acid.{16250} EPA has been shown to offer protection against coronary heart disease, thrombosis, ischemic brain injury, scaly dermatitis, and some inflammatory diseases.{32,208} Eicosapentaenoic acid (peroxide free) contains the antioxidant BHT (Item No. 89910). BHT-free eicosapentaenoic acid (Item Nos. 90110 | 21908) is also available.
Brand:CaymanSKU:90110.1 - 100 mgAvailable on backorder
EPA is an ω-3 fatty acid abundantly available in marine organisms.{48419} It is oxygenated by COX-1 and COX-2 at rates of about 5% and 30%, respectively, compared to arachidonic acid.{16250} EPA has been shown to offer protection against coronary heart disease, thrombosis, ischemic brain injury, scaly dermatitis, and some inflammatory diseases.{32,208} Eicosapentaenoic acid (peroxide free) contains the antioxidant BHT (Item No. 89910). BHT-free eicosapentaenoic acid (Item Nos. 90110 | 21908) is also available.
Brand:CaymanSKU:90110.1 - 250 mgAvailable on backorder
EPA is an ω-3 fatty acid abundantly available in marine organisms.{48419} It is oxygenated by COX-1 and COX-2 at rates of about 5% and 30%, respectively, compared to arachidonic acid.{16250} EPA has been shown to offer protection against coronary heart disease, thrombosis, ischemic brain injury, scaly dermatitis, and some inflammatory diseases.{32,208} Eicosapentaenoic acid (peroxide free) contains the antioxidant BHT (Item No. 89910). BHT-free eicosapentaenoic acid (Item Nos. 90110 | 21908) is also available.
Brand:CaymanSKU:90110.1 - 50 mgAvailable on backorder
EPA is an ω-3 fatty acid abundantly available in marine organisms. It is oxygenated by COX-1 and COX-2 at rates of approximately 5% and 30%, respectively, compared to arachidonic acid (Item No. 90010).{16250} EPA has been shown to offer protection against coronary heart disease, thrombosis, ischemic brain injury, scaly dermatitis, and some inflammatory diseases.{32,208}
Brand:CaymanSKU:21908 -Out of stock
EPA is an ω-3 fatty acid abundantly available in marine organisms. It is oxygenated by COX-1 and COX-2 at rates of approximately 5% and 30%, respectively, compared to arachidonic acid (Item No. 90010).{16250} EPA has been shown to offer protection against coronary heart disease, thrombosis, ischemic brain injury, scaly dermatitis, and some inflammatory diseases.{32,208}
Brand:CaymanSKU:21908 -Out of stock
EPA is an ω-3 fatty acid abundantly available in marine organisms. It is oxygenated by COX-1 and COX-2 at rates of approximately 5% and 30%, respectively, compared to arachidonic acid (Item No. 90010).{16250} EPA has been shown to offer protection against coronary heart disease, thrombosis, ischemic brain injury, scaly dermatitis, and some inflammatory diseases.{32,208}
Brand:CaymanSKU:21908 -Out of stock
EPA is an ω-3 fatty acid abundantly available in marine organisms. It is oxygenated by COX-1 and COX-2 at rates of approximately 5% and 30%, respectively, compared to arachidonic acid (Item No. 90010).{16250} EPA has been shown to offer protection against coronary heart disease, thrombosis, ischemic brain injury, scaly dermatitis, and some inflammatory diseases.{32,208}
Brand:CaymanSKU:21908 -Out of stock
Fish oils in the diet have anti-inflammatory and cardiovascular benefits due to an abundance of ω-3 polyunsaturated fatty acids (PUFAs), including eicosapentaenoic acid (EPA).{16509} EPA ethyl ester is a stabilized ethyl ester form of this ω-3 C20:5 PUFA. EPA competitively inhibits the metabolism of (ω-6) arachidonic acid by cyclooxygenase enzymes,{16250} suggesting that EPA ethyl ester may also directly modulate the actions of enzymes involved in fatty acid metabolism. In addition, dietary EPA ethyl ester in rats increases fatty acid β-oxidation enzyme levels,{16514,16499} indicating that EPA ethyl ester may alter the expression of genes related to fatty acid metabolism. Consistent with this concept, dietary supplementation with EPA ethyl ester in rats also down-regulates lipogenic genes, and decreases plasma cholesterol and triglyceride levels.{16497} Also, in rats fed a high-fat diet, supplementation with EPA ethyl ester blocks induced insulin resistance and corrects changes in adiponectin levels and TNF-α expression.{16498}
Brand:CaymanSKU:10008884 - 10 mgAvailable on backorder
Fish oils in the diet have anti-inflammatory and cardiovascular benefits due to an abundance of ω-3 polyunsaturated fatty acids (PUFAs), including eicosapentaenoic acid (EPA).{16509} EPA ethyl ester is a stabilized ethyl ester form of this ω-3 C20:5 PUFA. EPA competitively inhibits the metabolism of (ω-6) arachidonic acid by cyclooxygenase enzymes,{16250} suggesting that EPA ethyl ester may also directly modulate the actions of enzymes involved in fatty acid metabolism. In addition, dietary EPA ethyl ester in rats increases fatty acid β-oxidation enzyme levels,{16514,16499} indicating that EPA ethyl ester may alter the expression of genes related to fatty acid metabolism. Consistent with this concept, dietary supplementation with EPA ethyl ester in rats also down-regulates lipogenic genes, and decreases plasma cholesterol and triglyceride levels.{16497} Also, in rats fed a high-fat diet, supplementation with EPA ethyl ester blocks induced insulin resistance and corrects changes in adiponectin levels and TNF-α expression.{16498}
Brand:CaymanSKU:10008884 - 100 mgAvailable on backorder
Fish oils in the diet have anti-inflammatory and cardiovascular benefits due to an abundance of ω-3 polyunsaturated fatty acids (PUFAs), including eicosapentaenoic acid (EPA).{16509} EPA ethyl ester is a stabilized ethyl ester form of this ω-3 C20:5 PUFA. EPA competitively inhibits the metabolism of (ω-6) arachidonic acid by cyclooxygenase enzymes,{16250} suggesting that EPA ethyl ester may also directly modulate the actions of enzymes involved in fatty acid metabolism. In addition, dietary EPA ethyl ester in rats increases fatty acid β-oxidation enzyme levels,{16514,16499} indicating that EPA ethyl ester may alter the expression of genes related to fatty acid metabolism. Consistent with this concept, dietary supplementation with EPA ethyl ester in rats also down-regulates lipogenic genes, and decreases plasma cholesterol and triglyceride levels.{16497} Also, in rats fed a high-fat diet, supplementation with EPA ethyl ester blocks induced insulin resistance and corrects changes in adiponectin levels and TNF-α expression.{16498}
Brand:CaymanSKU:10008884 - 50 mgAvailable on backorder
Fish oils in the diet have anti-inflammatory and cardiovascular benefits due to an abundance of ω-3 polyunsaturated fatty acids (PUFAs), including eicosapentaenoic acid (EPA).{16509} EPA ethyl ester is a stabilized ethyl ester form of this ω-3 C20:5 PUFA. EPA competitively inhibits the metabolism of (ω-6) arachidonic acid by cyclooxygenase enzymes,{16250} suggesting that EPA ethyl ester may also directly modulate the actions of enzymes involved in fatty acid metabolism. In addition, dietary EPA ethyl ester in rats increases fatty acid β-oxidation enzyme levels,{16514,16499} indicating that EPA ethyl ester may alter the expression of genes related to fatty acid metabolism. Consistent with this concept, dietary supplementation with EPA ethyl ester in rats also down-regulates lipogenic genes, and decreases plasma cholesterol and triglyceride levels.{16497} Also, in rats fed a high-fat diet, supplementation with EPA ethyl ester blocks induced insulin resistance and corrects changes in adiponectin levels and TNF-α expression.{16498}
Brand:CaymanSKU:10008884 - 500 mgAvailable on backorder
Eicosapentaenoic acid is an ω-3 fatty acid abundantly available in marine organisms. It is oxygenated by COX-1 and COX-2 at rates of about 5% and 30%, respectively, compared to arachidonic acid.{16250} Eicosapentaenoic acid has been shown to offer protection against coronary heart disease, thrombosis, ischemic brain injury, scaly dermatitis, and some inflammatory diseases.{32,208} Eicosapentaenoic acid MaxSpec® standard is a quantitative grade standard of eicosapentaenoic acid (Item No. 90110) that has been prepared specifically for mass spectrometry and related applications where quantitative reproducibility is required. The solution has been prepared gravimetrically and is supplied in a deactivated glass ampule sealed under argon. The concentration was verified by comparison to an independently prepared calibration standard. This eicosapentaenoic acid MaxSpec® standard is guaranteed to meet identity, purity, stability, and concentration specifications and is provided with a batch-specific certificate of analysis. Ongoing stability testing is performed to ensure the concentration remains accurate throughout the shelf life of the product. Note: The amount of solution added to the vial is in excess of the listed amount. Therefore, it is necessary to accurately measure volumes for preparation of calibration standards. Follow recommended storage and handling conditions to maintain product quality.
Brand:CaymanSKU:26415 - 1 mgAvailable on backorder
Eicosapentaenoic acid (EPA) is an ω-3 fatty acid which can have beneficial effects on vascular and immune physiology.{20051,20050,20049} Also, EPA serves as a precursor for resolvins, mediators that help resolve inflammatory processes.{20052} Eicosapentaenoic acid (EPA) methyl ester is an esterified form of EPA (Item Nos. 90110 | 90110.1 | 21908). It has been used as a reference standard in the quantification of fatty acids in microalgal and fish oils.{54169}
Brand:CaymanSKU:9000295 - 10 mgAvailable on backorder