Cayman
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Cathinone, the main psychoactive alkaloid from the khat plant (C. edulis), is a potent central stimulant and a naturally occurring analog of amphetamine. Cathinone, the main psychoactive alkaloid from the khat plant (C. edulis), is a potent central stimulant and a naturally occurring analog of amphetamine. DL-Cathinone is a racemic mixture of (−)-(S)-cathinone (Item No. 13869) and its less potent (+)-isomer.{20224} Like amphetamine, DL-cathinone and (−)-(S)-cathinone are potent releasers of norepinephrine and dopamine.{21931,21932,23301} With an ED50 value of 0.24 mg/kg, DL-cathinone produces amphetamine-like effects on the operant behavior of rats trained to discriminate 0.2-0.8 mg/kg of (D)-amphetamine.{23301} This product is intended for research and forensic applications.
Brand:CaymanSKU:-
DL-erythro/threo Sphinganine (d16:0) is a sphingolipid that is decreased in rats following long-term, low-dose administration of dimethoate and is used as a biomarker for dimethoate exposure.{40989} It has been found in the fermentation broth of Bacterium SRCnm, which has antimicrobial and antioxidant activities.{40990} This product is a mixture of sphinganine (d16:0), L-erythro sphinganine (d16:0), D-threo sphinganine (d16:0), and L-threo sphinganine (d16:0). [Matreya, LLC. Catalog No. 1326]
Brand:CaymanSKU:24376 - 1 mgAvailable on backorder
DL-erythro/threo Sphinganine (d16:0) is a sphingolipid that is decreased in rats following long-term, low-dose administration of dimethoate and is used as a biomarker for dimethoate exposure.{40989} It has been found in the fermentation broth of Bacterium SRCnm, which has antimicrobial and antioxidant activities.{40990} This product is a mixture of sphinganine (d16:0), L-erythro sphinganine (d16:0), D-threo sphinganine (d16:0), and L-threo sphinganine (d16:0). [Matreya, LLC. Catalog No. 1326]
Brand:CaymanSKU:24376 - 10 mgAvailable on backorder
DL-erythro/threo Sphinganine (d16:0) is a sphingolipid that is decreased in rats following long-term, low-dose administration of dimethoate and is used as a biomarker for dimethoate exposure.{40989} It has been found in the fermentation broth of Bacterium SRCnm, which has antimicrobial and antioxidant activities.{40990} This product is a mixture of sphinganine (d16:0), L-erythro sphinganine (d16:0), D-threo sphinganine (d16:0), and L-threo sphinganine (d16:0). [Matreya, LLC. Catalog No. 1326]
Brand:CaymanSKU:24376 - 5 mgAvailable on backorder
DL-erythro Sphinganine (d18:0) is a precursor of ceramide and sphingosine as well as a substrate of sphingosine kinases, which generate sphinganine-1-phosphate (Item No. 22500).{7049} Sphinganine levels increase significantly in response to certain mycotoxins, including fumonisins as well as in some cancers.{18298,18299,18300} This product is a mixture of sphinganine (d18:0) (Item No. 10007945), L-erythro sphinganine (d18:0) (Item No. 24374), D-threo sphinganine (d18:0) (Item No. 24375), and L-threo sphinganine (d18:0). [Matreya, LLC. Catalog No. 1324]
Brand:CaymanSKU:24367 - 25 mgAvailable on backorder
DL-Folinic acid is a formylated form of tetrahydrofolic acid (Item No. 18263), the reduced form of folic acid, a B vitamin. DL-Folinic acid is used to prevent toxicity following therapy with high-dose methotrexate (Item No. 13960), to enhance the antitumor activity of 5-fluorouracil (Item No. 14416), and as a folate supplement.{32087,25271}
Brand:CaymanSKU:20383 -Available on backorder
DL-Folinic acid is a formylated form of tetrahydrofolic acid (Item No. 18263), the reduced form of folic acid, a B vitamin. DL-Folinic acid is used to prevent toxicity following therapy with high-dose methotrexate (Item No. 13960), to enhance the antitumor activity of 5-fluorouracil (Item No. 14416), and as a folate supplement.{32087,25271}
Brand:CaymanSKU:20383 -Available on backorder
DL-Folinic acid is a formylated form of tetrahydrofolic acid (Item No. 18263), the reduced form of folic acid, a B vitamin. DL-Folinic acid is used to prevent toxicity following therapy with high-dose methotrexate (Item No. 13960), to enhance the antitumor activity of 5-fluorouracil (Item No. 14416), and as a folate supplement.{32087,25271}
Brand:CaymanSKU:20383 -Available on backorder
DL-Glyceraldehyde-3-phosphate (GADP) is an intermediate in several metabolic pathways, including glycolysis and gluconeogenesis. In glycolysis, it can be derived from fructose 1,6-bisphosphate by fructose bisphosphate aldolase in a reaction that also produces dihydroxyacetone phosphate (DHAP). Triose phosphate isomerase reversibly converts DHAP to GADP. GADP is processed to 1,3-bisphosphoglycerate by glyceraldehyde phosphate dehydrogenase and NAD+.
Brand:CaymanSKU:-Available on backorder
DL-Glyceraldehyde-3-phosphate (GADP) is an intermediate in several metabolic pathways, including glycolysis and gluconeogenesis. In glycolysis, it can be derived from fructose 1,6-bisphosphate by fructose bisphosphate aldolase in a reaction that also produces dihydroxyacetone phosphate (DHAP). Triose phosphate isomerase reversibly converts DHAP to GADP. GADP is processed to 1,3-bisphosphoglycerate by glyceraldehyde phosphate dehydrogenase and NAD+.
Brand:CaymanSKU:-Available on backorder
DL-Glyceraldehyde-3-phosphate (GADP) is an intermediate in several metabolic pathways, including glycolysis and gluconeogenesis. In glycolysis, it can be derived from fructose 1,6-bisphosphate by fructose bisphosphate aldolase in a reaction that also produces dihydroxyacetone phosphate (DHAP). Triose phosphate isomerase reversibly converts DHAP to GADP. GADP is processed to 1,3-bisphosphoglycerate by glyceraldehyde phosphate dehydrogenase and NAD+.
Brand:CaymanSKU:-Available on backorder
DL-Glyceraldehyde-3-phosphate (GADP) is an intermediate in several metabolic pathways, including glycolysis and gluconeogenesis. In glycolysis, it can be derived from fructose 1,6-bisphosphate by fructose bisphosphate aldolase in a reaction that also produces dihydroxyacetone phosphate (DHAP). Triose phosphate isomerase reversibly converts DHAP to GADP. GADP is processed to 1,3-bisphosphoglycerate by glyceraldehyde phosphate dehydrogenase and NAD+.
Brand:CaymanSKU:-Available on backorder
DL-Homocysteine is a thiol-containing amino acid derived from methionine.{48974} It inhibits vasodilation of precontracted isolated guinea pig pulmonary artery rings induced by acetylcholine (ACh) and enhances potassium chloride- and phenylephrine-induced contraction of isolated guinea pig pulmonary artery rings.{48975} DL-Homocysteine (200 µM) inhibits endothelium-dependent ACh-induced vasodilation in the vascular bed of isolated perfused rat pancreas.{48976} Elevated plasma levels of DL-homocysteine are positively correlated with occlusive arterial diseases and atherosclerosis.{48974,48975}
Brand:CaymanSKU:30285 - 1 gAvailable on backorder
DL-Homocysteine is a thiol-containing amino acid derived from methionine.{48974} It inhibits vasodilation of precontracted isolated guinea pig pulmonary artery rings induced by acetylcholine (ACh) and enhances potassium chloride- and phenylephrine-induced contraction of isolated guinea pig pulmonary artery rings.{48975} DL-Homocysteine (200 µM) inhibits endothelium-dependent ACh-induced vasodilation in the vascular bed of isolated perfused rat pancreas.{48976} Elevated plasma levels of DL-homocysteine are positively correlated with occlusive arterial diseases and atherosclerosis.{48974,48975}
Brand:CaymanSKU:30285 - 500 mgAvailable on backorder
DL-Homocysteine thiolactone is a derivative of DL-homocysteine (Item No. 30285).{54414} It inhibits the growth of B. campestris, L. sativa, and E. utilis roots when used at a concentration of 50 µM.{54415} DL-Homocysteine thiolactone (10 µM) decreases the maximum rate of left ventricular developed pressure, systolic left ventricular pressure, and coronary flow in isolated rat hearts.{54416} It induces arteriosclerotic plaque formation in rabbits when administered at a dose of 30 mg/kg for eight weeks.{54414} DL-Homocysteine thiolactone has also been used as a precursor in the synthesis of thiolactone-containing monomers for use in polymer-based formaldehyde-scavenging coatings.{54417}
Brand:CaymanSKU:31466 - 100 gAvailable on backorder
DL-Homocysteine thiolactone is a derivative of DL-homocysteine (Item No. 30285).{54414} It inhibits the growth of B. campestris, L. sativa, and E. utilis roots when used at a concentration of 50 µM.{54415} DL-Homocysteine thiolactone (10 µM) decreases the maximum rate of left ventricular developed pressure, systolic left ventricular pressure, and coronary flow in isolated rat hearts.{54416} It induces arteriosclerotic plaque formation in rabbits when administered at a dose of 30 mg/kg for eight weeks.{54414} DL-Homocysteine thiolactone has also been used as a precursor in the synthesis of thiolactone-containing monomers for use in polymer-based formaldehyde-scavenging coatings.{54417}
Brand:CaymanSKU:31466 - 250 gAvailable on backorder
DL-Homocysteine thiolactone is a derivative of DL-homocysteine (Item No. 30285).{54414} It inhibits the growth of B. campestris, L. sativa, and E. utilis roots when used at a concentration of 50 µM.{54415} DL-Homocysteine thiolactone (10 µM) decreases the maximum rate of left ventricular developed pressure, systolic left ventricular pressure, and coronary flow in isolated rat hearts.{54416} It induces arteriosclerotic plaque formation in rabbits when administered at a dose of 30 mg/kg for eight weeks.{54414} DL-Homocysteine thiolactone has also been used as a precursor in the synthesis of thiolactone-containing monomers for use in polymer-based formaldehyde-scavenging coatings.{54417}
Brand:CaymanSKU:31466 - 50 gAvailable on backorder
DL-Homocysteine thiolactone is a derivative of DL-homocysteine (Item No. 30285).{54414} It inhibits the growth of B. campestris, L. sativa, and E. utilis roots when used at a concentration of 50 µM.{54415} DL-Homocysteine thiolactone (10 µM) decreases the maximum rate of left ventricular developed pressure, systolic left ventricular pressure, and coronary flow in isolated rat hearts.{54416} It induces arteriosclerotic plaque formation in rabbits when administered at a dose of 30 mg/kg for eight weeks.{54414} DL-Homocysteine thiolactone has also been used as a precursor in the synthesis of thiolactone-containing monomers for use in polymer-based formaldehyde-scavenging coatings.{54417}
Brand:CaymanSKU:31466 - 500 gAvailable on backorder
DL-Mevalonolactone is the δ-lactone form of mevalonic acid, a precursor in the mevalonate pathway.{36829} It induces depolarization and swelling, decreases NADPH content and aconitase (ACO) activity, and increases malondialdehyde (MDA) production in calcium-loaded rat brain mitochondria.{36830} DL-Mevalonolactone reverses decreases in glucose uptake induced by simvastatin (Item Nos. 10010344 | 10010345) in L6 myotubes.{36831} Tissue levels and urinary excretion of DL-mevalonolactone are increased in patients with mevalonic aciduria, a disorder characterized by a deficiency in mevalonic kinase activity.{36830}
Brand:CaymanSKU:20348 -Available on backorder
DL-Mevalonolactone is the δ-lactone form of mevalonic acid, a precursor in the mevalonate pathway.{36829} It induces depolarization and swelling, decreases NADPH content and aconitase (ACO) activity, and increases malondialdehyde (MDA) production in calcium-loaded rat brain mitochondria.{36830} DL-Mevalonolactone reverses decreases in glucose uptake induced by simvastatin (Item Nos. 10010344 | 10010345) in L6 myotubes.{36831} Tissue levels and urinary excretion of DL-mevalonolactone are increased in patients with mevalonic aciduria, a disorder characterized by a deficiency in mevalonic kinase activity.{36830}
Brand:CaymanSKU:20348 -Available on backorder
DL-Mevalonolactone is the δ-lactone form of mevalonic acid, a precursor in the mevalonate pathway.{36829} It induces depolarization and swelling, decreases NADPH content and aconitase (ACO) activity, and increases malondialdehyde (MDA) production in calcium-loaded rat brain mitochondria.{36830} DL-Mevalonolactone reverses decreases in glucose uptake induced by simvastatin (Item Nos. 10010344 | 10010345) in L6 myotubes.{36831} Tissue levels and urinary excretion of DL-mevalonolactone are increased in patients with mevalonic aciduria, a disorder characterized by a deficiency in mevalonic kinase activity.{36830}
Brand:CaymanSKU:20348 -Available on backorder
Hydrogen sulphide (H2S), a naturally occurring gasotransmitter, is a potent vasodilator and pro-inflammatory mediator.{15636} DL-Propargyl glycine (PAG) is an irreversible inhibitor of the H2S synthesizing enzyme cystathionine-γ-lyase (CSE). PAG blocks H2S synthesis activity in rat liver preparations with an IC50 value of 55 µM and abolishes the rise in plasma H2S in anaesthetized rats induced with hemorrhagic shock.{16094} At concentrations ranging from 25-100 mg/kg, PAG can reduce H2S-associated inflammation in rodent models of pancreatitis, oedema, and endotoxemia.{16095,16096,16097}
Brand:CaymanSKU:10010948 - 1 mgAvailable on backorder
Hydrogen sulphide (H2S), a naturally occurring gasotransmitter, is a potent vasodilator and pro-inflammatory mediator.{15636} DL-Propargyl glycine (PAG) is an irreversible inhibitor of the H2S synthesizing enzyme cystathionine-γ-lyase (CSE). PAG blocks H2S synthesis activity in rat liver preparations with an IC50 value of 55 µM and abolishes the rise in plasma H2S in anaesthetized rats induced with hemorrhagic shock.{16094} At concentrations ranging from 25-100 mg/kg, PAG can reduce H2S-associated inflammation in rodent models of pancreatitis, oedema, and endotoxemia.{16095,16096,16097}
Brand:CaymanSKU:10010948 - 10 mgAvailable on backorder
Hydrogen sulphide (H2S), a naturally occurring gasotransmitter, is a potent vasodilator and pro-inflammatory mediator.{15636} DL-Propargyl glycine (PAG) is an irreversible inhibitor of the H2S synthesizing enzyme cystathionine-γ-lyase (CSE). PAG blocks H2S synthesis activity in rat liver preparations with an IC50 value of 55 µM and abolishes the rise in plasma H2S in anaesthetized rats induced with hemorrhagic shock.{16094} At concentrations ranging from 25-100 mg/kg, PAG can reduce H2S-associated inflammation in rodent models of pancreatitis, oedema, and endotoxemia.{16095,16096,16097}
Brand:CaymanSKU:10010948 - 5 mgAvailable on backorder
Hydrogen sulphide (H2S), a naturally occurring gasotransmitter, is a potent vasodilator and pro-inflammatory mediator.{15636} DL-Propargyl glycine (PAG) is an irreversible inhibitor of the H2S synthesizing enzyme cystathionine-γ-lyase (CSE). PAG blocks H2S synthesis activity in rat liver preparations with an IC50 value of 55 µM and abolishes the rise in plasma H2S in anaesthetized rats induced with hemorrhagic shock.{16094} At concentrations ranging from 25-100 mg/kg, PAG can reduce H2S-associated inflammation in rodent models of pancreatitis, oedema, and endotoxemia.{16095,16096,16097}
Brand:CaymanSKU:10010948 - 50 mgAvailable on backorder
Nrf2 activation of the antioxidant response element (ARE) is central to cytoprotective gene expression against oxidative and/or electrophilic stress.{17702} Unless activated by inflammatory, environmental, or oxidative stressors, Nrf2 is sequestered in the cytoplasm by its repressor, Keap1.{16386} Because of its protective capabilities, small molecules that activate Nrf2 signaling are being examined as potential anti-cancer or anti-inflammatory agents.{20661} DL-Sulforaphane N-acetyl-L-cysteine (SFN-NAC) is a major metabolite of SFN (Item No. 10496), a powerful inducer of chemopreventative enzymes via Keap1-Nrf2 signaling and ARE-driven gene expression.{21473,26231} At 75 µM, SFN-NAC has been shown to increase ARE expression in HepG2-C8 cells.{26230} Its reported potency on ARE-related gene expression is roughly 8-fold less than SFN.{26230}
Brand:CaymanSKU:- Nrf2 activation of the antioxidant response element (ARE) is central to cytoprotective gene expression against oxidative and/or electrophilic stress.{17702} Unless activated by inflammatory, environmental, or oxidative stressors, Nrf2 is sequestered in the cytoplasm by its repressor, Keap1.{16386} Because of its protective capabilities, small molecules that activate Nrf2 signaling are being examined as potential anti-cancer or anti-inflammatory agents.{20661} DL-Sulforaphane N-acetyl-L-cysteine (SFN-NAC) is a major metabolite of SFN (Item No. 10496), a powerful inducer of chemopreventative enzymes via Keap1-Nrf2 signaling and ARE-driven gene expression.{21473,26231} At 75 µM, SFN-NAC has been shown to increase ARE expression in HepG2-C8 cells.{26230} Its reported potency on ARE-related gene expression is roughly 8-fold less than SFN.{26230}
Brand:CaymanSKU:- Nrf2 activation of the antioxidant response element (ARE) is central to cytoprotective gene expression against oxidative and/or electrophilic stress.{17702} Unless activated by inflammatory, environmental, or oxidative stressors, Nrf2 is sequestered in the cytoplasm by its repressor, Keap1.{16386} Because of its protective capabilities, small molecules that activate Nrf2 signaling are being examined as potential anti-cancer or anti-inflammatory agents.{20661} DL-Sulforaphane N-acetyl-L-cysteine (SFN-NAC) is a major metabolite of SFN (Item No. 10496), a powerful inducer of chemopreventative enzymes via Keap1-Nrf2 signaling and ARE-driven gene expression.{21473,26231} At 75 µM, SFN-NAC has been shown to increase ARE expression in HepG2-C8 cells.{26230} Its reported potency on ARE-related gene expression is roughly 8-fold less than SFN.{26230}
Brand:CaymanSKU:-
DL-TBOA is an inhibitor of excitatory amino acid transporters (EAATs), with IC50 values of 67 and 5.5 μM for glutamate uptake in COS-1 cells expressing human EAAT1 and EAAT2, respectively.{45698} It inhibits inward currents induced by L-aspartate in EAAT4-expressing Xenopus oocytes (Ki = 4.4 μM) and by L-glutamate in EAAT5-expressing oocytes (Ki = 3.2 μM) voltage-clamped at -60 mV.{45699} In vivo, DL-TBOA (500 μM, intrahippocampal perfusion) increases extracellular aspartate, glutamate, and alanine levels in rat hippocampus.{45700} Intrahippocampal injection of DL-TBOA increases lesion volume in the rat CA1 region in a dose-dependent manner and induces hyperexcitability, wet-dog shakes, salivation, forelimb myoclonus, limbic seizures, and epileptic EEG discharges at a dose of 25 nmol. DL-TBOA (5 and 10 μg, intrathecal) induces antinociception in the second phase of the formalin test in rats when administered 10 minutes prior to formalin.{45701}
Brand:CaymanSKU:29632 - 10 mgAvailable on backorder
DL-TBOA is an inhibitor of excitatory amino acid transporters (EAATs), with IC50 values of 67 and 5.5 μM for glutamate uptake in COS-1 cells expressing human EAAT1 and EAAT2, respectively.{45698} It inhibits inward currents induced by L-aspartate in EAAT4-expressing Xenopus oocytes (Ki = 4.4 μM) and by L-glutamate in EAAT5-expressing oocytes (Ki = 3.2 μM) voltage-clamped at -60 mV.{45699} In vivo, DL-TBOA (500 μM, intrahippocampal perfusion) increases extracellular aspartate, glutamate, and alanine levels in rat hippocampus.{45700} Intrahippocampal injection of DL-TBOA increases lesion volume in the rat CA1 region in a dose-dependent manner and induces hyperexcitability, wet-dog shakes, salivation, forelimb myoclonus, limbic seizures, and epileptic EEG discharges at a dose of 25 nmol. DL-TBOA (5 and 10 μg, intrathecal) induces antinociception in the second phase of the formalin test in rats when administered 10 minutes prior to formalin.{45701}
Brand:CaymanSKU:29632 - 5 mgAvailable on backorder
DL-threo PDMP is a mixture of ceramide analogs that contains two of the four possible stereoisomers of PDMP (Item No. 62595): D-threo (1R,2R) and L-threo (1S,2S) PDMP.{11392} DL-threo-PDMP inhibits glucosylceramide synthase by 33 and 48% in MDCK cell homogenates when used at concentrations of 5 and 10 µM.{11341} It reduces the synthesis of glucosylceramide, increases cellular ceramide, and induces cell cycle arrest in vitro.{11342} The ability to inhibit glucosylceramide synthase has been found to reside in the D-threo (1R,2R) enantiomer.{11393} The D-threo PDMP enantiomer is also responsible for inhibition of β-1,4-galactosyltransferase 6 and prevention of lactosylceramide synthesis, which is a promotor of neuroinflammation in mice during chronic experimental autoimmune encephalomyelitis (EAE), a model of multiple sclerosis.{27728} DL-threo-PDMP increases amyloid-β (1-42) (Aβ42) and Aβ39 production independent of ceramide metabolism via modulation of γ-secretase activity in HEK293 cells expressing the γ-secretase substrate SC100.{36880}
Brand:CaymanSKU:10005276 - 10 mgAvailable on backorder
DL-threo PDMP is a mixture of ceramide analogs that contains two of the four possible stereoisomers of PDMP (Item No. 62595): D-threo (1R,2R) and L-threo (1S,2S) PDMP.{11392} DL-threo-PDMP inhibits glucosylceramide synthase by 33 and 48% in MDCK cell homogenates when used at concentrations of 5 and 10 µM.{11341} It reduces the synthesis of glucosylceramide, increases cellular ceramide, and induces cell cycle arrest in vitro.{11342} The ability to inhibit glucosylceramide synthase has been found to reside in the D-threo (1R,2R) enantiomer.{11393} The D-threo PDMP enantiomer is also responsible for inhibition of β-1,4-galactosyltransferase 6 and prevention of lactosylceramide synthesis, which is a promotor of neuroinflammation in mice during chronic experimental autoimmune encephalomyelitis (EAE), a model of multiple sclerosis.{27728} DL-threo-PDMP increases amyloid-β (1-42) (Aβ42) and Aβ39 production independent of ceramide metabolism via modulation of γ-secretase activity in HEK293 cells expressing the γ-secretase substrate SC100.{36880}
Brand:CaymanSKU:10005276 - 100 mgAvailable on backorder
DL-threo PDMP is a mixture of ceramide analogs that contains two of the four possible stereoisomers of PDMP (Item No. 62595): D-threo (1R,2R) and L-threo (1S,2S) PDMP.{11392} DL-threo-PDMP inhibits glucosylceramide synthase by 33 and 48% in MDCK cell homogenates when used at concentrations of 5 and 10 µM.{11341} It reduces the synthesis of glucosylceramide, increases cellular ceramide, and induces cell cycle arrest in vitro.{11342} The ability to inhibit glucosylceramide synthase has been found to reside in the D-threo (1R,2R) enantiomer.{11393} The D-threo PDMP enantiomer is also responsible for inhibition of β-1,4-galactosyltransferase 6 and prevention of lactosylceramide synthesis, which is a promotor of neuroinflammation in mice during chronic experimental autoimmune encephalomyelitis (EAE), a model of multiple sclerosis.{27728} DL-threo-PDMP increases amyloid-β (1-42) (Aβ42) and Aβ39 production independent of ceramide metabolism via modulation of γ-secretase activity in HEK293 cells expressing the γ-secretase substrate SC100.{36880}
Brand:CaymanSKU:10005276 - 5 mgAvailable on backorder
DL-threo PDMP is a mixture of ceramide analogs that contains two of the four possible stereoisomers of PDMP (Item No. 62595): D-threo (1R,2R) and L-threo (1S,2S) PDMP.{11392} DL-threo-PDMP inhibits glucosylceramide synthase by 33 and 48% in MDCK cell homogenates when used at concentrations of 5 and 10 µM.{11341} It reduces the synthesis of glucosylceramide, increases cellular ceramide, and induces cell cycle arrest in vitro.{11342} The ability to inhibit glucosylceramide synthase has been found to reside in the D-threo (1R,2R) enantiomer.{11393} The D-threo PDMP enantiomer is also responsible for inhibition of β-1,4-galactosyltransferase 6 and prevention of lactosylceramide synthesis, which is a promotor of neuroinflammation in mice during chronic experimental autoimmune encephalomyelitis (EAE), a model of multiple sclerosis.{27728} DL-threo-PDMP increases amyloid-β (1-42) (Aβ42) and Aβ39 production independent of ceramide metabolism via modulation of γ-secretase activity in HEK293 cells expressing the γ-secretase substrate SC100.{36880}
Brand:CaymanSKU:10005276 - 50 mgAvailable on backorder
DL-threo-PPMP is a ceramide analog and an inhibitor of glucosylceramide synthase.{11391} It inhibits glucosylceramide synthase by 70, 41, and 62% in MDCK cell homogenates, mouse liver microsomes, and mouse brain homogenates, respectively, when used at a concentration of 20 µM. DL-threo-PPMP also inhibits sphingomyelin synthase activity in erythrocytes infected with P. falciparum and inhibits late ring-stage P. falciparum growth (IC50 = 0.85 µM).{48898} It reduces Akt and ribosomal protein S6 phosphorylation in HEK293 cells and increases autophagy flux in primary mouse neurons.{28272} [Matreya, LLC. Catalog No. 1720]
Brand:CaymanSKU:-Out of stock
DL-threo-PPMP is a ceramide analog and an inhibitor of glucosylceramide synthase.{11391} It inhibits glucosylceramide synthase by 70, 41, and 62% in MDCK cell homogenates, mouse liver microsomes, and mouse brain homogenates, respectively, when used at a concentration of 20 µM. DL-threo-PPMP also inhibits sphingomyelin synthase activity in erythrocytes infected with P. falciparum and inhibits late ring-stage P. falciparum growth (IC50 = 0.85 µM).{48898} It reduces Akt and ribosomal protein S6 phosphorylation in HEK293 cells and increases autophagy flux in primary mouse neurons.{28272} [Matreya, LLC. Catalog No. 1720]
Brand:CaymanSKU:-Out of stock
DL-threo-PPMP is a ceramide analog and an inhibitor of glucosylceramide synthase.{11391} It inhibits glucosylceramide synthase by 70, 41, and 62% in MDCK cell homogenates, mouse liver microsomes, and mouse brain homogenates, respectively, when used at a concentration of 20 µM. DL-threo-PPMP also inhibits sphingomyelin synthase activity in erythrocytes infected with P. falciparum and inhibits late ring-stage P. falciparum growth (IC50 = 0.85 µM).{48898} It reduces Akt and ribosomal protein S6 phosphorylation in HEK293 cells and increases autophagy flux in primary mouse neurons.{28272} [Matreya, LLC. Catalog No. 1720]
Brand:CaymanSKU:-Out of stock
DL-threo-PPMP is a ceramide analog and an inhibitor of glucosylceramide synthase.{11391} It inhibits glucosylceramide synthase by 70, 41, and 62% in MDCK cell homogenates, mouse liver microsomes, and mouse brain homogenates, respectively, when used at a concentration of 20 µM. DL-threo-PPMP also inhibits sphingomyelin synthase activity in erythrocytes infected with P. falciparum and inhibits late ring-stage P. falciparum growth (IC50 = 0.85 µM).{48898} It reduces Akt and ribosomal protein S6 phosphorylation in HEK293 cells and increases autophagy flux in primary mouse neurons.{28272} [Matreya, LLC. Catalog No. 1720]
Brand:CaymanSKU:-Out of stock
DL-Tryptophan is a racemic mixture of the atypical amino acid D-tryptophan and the essential amino acid L-tryptophan (Item No. 29600).{57330,53275} Serum levels of DL-tryptophan are negatively correlated with urinary protein levels in a rat model of nephropathy induced by doxorubicin (Item No. 15007).{57329}
Brand:CaymanSKU:31210 - 100 gAvailable on backorder
DL-Tryptophan is a racemic mixture of the atypical amino acid D-tryptophan and the essential amino acid L-tryptophan (Item No. 29600).{57330,53275} Serum levels of DL-tryptophan are negatively correlated with urinary protein levels in a rat model of nephropathy induced by doxorubicin (Item No. 15007).{57329}
Brand:CaymanSKU:31210 - 25 gAvailable on backorder
DL-Tryptophan is a racemic mixture of the atypical amino acid D-tryptophan and the essential amino acid L-tryptophan (Item No. 29600).{57330,53275} Serum levels of DL-tryptophan are negatively correlated with urinary protein levels in a rat model of nephropathy induced by doxorubicin (Item No. 15007).{57329}
Brand:CaymanSKU:31210 - 50 gAvailable on backorder
Tryptophan is an amino acid precursor of serotonin and melatonin. DL-Tryptophan octyl ester is a tryptophan derivative with an octyl ester protected COOH group.{28752} This addition creates a stable, cell-permeable molecule capable of generating free tryptophan upon hydrolysis of the ester bond.
Brand:CaymanSKU:-Available on backorder
Tryptophan is an amino acid precursor of serotonin and melatonin. DL-Tryptophan octyl ester is a tryptophan derivative with an octyl ester protected COOH group.{28752} This addition creates a stable, cell-permeable molecule capable of generating free tryptophan upon hydrolysis of the ester bond.
Brand:CaymanSKU:-Available on backorder
Tryptophan is an amino acid precursor of serotonin and melatonin. DL-Tryptophan octyl ester is a tryptophan derivative with an octyl ester protected COOH group.{28752} This addition creates a stable, cell-permeable molecule capable of generating free tryptophan upon hydrolysis of the ester bond.
Brand:CaymanSKU:-Available on backorder
DL-α-Difluoromethylornithine (DFMO) is an irreversible inhibitor of ornithine decarboxylase that suppresses polyamine biosynthesis.{27553} DFMO displays antiangiogenic and cytostatic effects in tumor cells but must be used in combination with other chemotherapeutic agents to negate compensatory increases in polyamine content through alternate synthesis pathways.{27553,27552,27554,27555} Through inhibition of polyamine synthesis, DFMO also demonstrates antiparasitic activity in a model of C. parvum infection.{26876}
Brand:CaymanSKU:-Out of stock
DL-α-Difluoromethylornithine (DFMO) is an irreversible inhibitor of ornithine decarboxylase that suppresses polyamine biosynthesis.{27553} DFMO displays antiangiogenic and cytostatic effects in tumor cells but must be used in combination with other chemotherapeutic agents to negate compensatory increases in polyamine content through alternate synthesis pathways.{27553,27552,27554,27555} Through inhibition of polyamine synthesis, DFMO also demonstrates antiparasitic activity in a model of C. parvum infection.{26876}
Brand:CaymanSKU:-Out of stock
DL-α-Difluoromethylornithine (DFMO) is an irreversible inhibitor of ornithine decarboxylase that suppresses polyamine biosynthesis.{27553} DFMO displays antiangiogenic and cytostatic effects in tumor cells but must be used in combination with other chemotherapeutic agents to negate compensatory increases in polyamine content through alternate synthesis pathways.{27553,27552,27554,27555} Through inhibition of polyamine synthesis, DFMO also demonstrates antiparasitic activity in a model of C. parvum infection.{26876}
Brand:CaymanSKU:-Out of stock
DL-α-Difluoromethylornithine (DFMO) is an irreversible inhibitor of ornithine decarboxylase that suppresses polyamine biosynthesis.{27553} DFMO displays antiangiogenic and cytostatic effects in tumor cells but must be used in combination with other chemotherapeutic agents to negate compensatory increases in polyamine content through alternate synthesis pathways.{27553,27552,27554,27555} Through inhibition of polyamine synthesis, DFMO also demonstrates antiparasitic activity in a model of C. parvum infection.{26876}
Brand:CaymanSKU:-Out of stock
DL-α-Lipoic acid is a cyclic disulfide antioxidant that interconverts with its reduced dithiol form. It is an essential cofactor for decarboxylation reactions of the citric acid cycle, and acts as a general antioxidant.{12280,12281,12322} DL-α-lipoic acid can act as a direct radical scavenger, as a cofactor to regenerate reduced glutathione, and as a metal chelator.
Brand:CaymanSKU:10005728 - 1 gAvailable on backorder
DL-α-Lipoic acid is a cyclic disulfide antioxidant that interconverts with its reduced dithiol form. It is an essential cofactor for decarboxylation reactions of the citric acid cycle, and acts as a general antioxidant.{12280,12281,12322} DL-α-lipoic acid can act as a direct radical scavenger, as a cofactor to regenerate reduced glutathione, and as a metal chelator.
Brand:CaymanSKU:10005728 - 10 gAvailable on backorder
DL-α-Lipoic acid is a cyclic disulfide antioxidant that interconverts with its reduced dithiol form. It is an essential cofactor for decarboxylation reactions of the citric acid cycle, and acts as a general antioxidant.{12280,12281,12322} DL-α-lipoic acid can act as a direct radical scavenger, as a cofactor to regenerate reduced glutathione, and as a metal chelator.
Brand:CaymanSKU:10005728 - 25 gAvailable on backorder
DL-α-Lipoic acid is a cyclic disulfide antioxidant that interconverts with its reduced dithiol form. It is an essential cofactor for decarboxylation reactions of the citric acid cycle, and acts as a general antioxidant.{12280,12281,12322} DL-α-lipoic acid can act as a direct radical scavenger, as a cofactor to regenerate reduced glutathione, and as a metal chelator.
Brand:CaymanSKU:10005728 - 5 gAvailable on backorder
DLAC is a detergent synthesized from lactobionic acid.{40970,40971} It can be used to solubilize membrane proteins and has a critical micelle concentration (CMC) of 1.3 mM.
Brand:CaymanSKU:24780 - 250 mgAvailable on backorder
N2′-deacetyl-N2′-[3-[[1-[[4-[[(2,5-dioxo-1-pyrrolidinyl)oxy]carbonyl]cyclohexyl]methyl]-2,5-dioxo-3-pyrrolidinyl]thio]-1-oxopropyl]-maytansine DM1-SMCC is a cleavable linker-based antibody-drug conjugate (ADC) containing the maytansinoid DM1 (mertansine; Item No. 22483) and the crosslinker SMCC.{35225,35224} ADCs target specific cell populations to induce a selective response, such as cell death in cancer cells. DM1-SMCC conjugated to an anti-CD70 antibody has been used to study the transport of the ADC catabolites into the cell cytoplasm of 786-0 renal cell carcinoma cells.
Brand:CaymanSKU:23926 - 1 mgAvailable on backorder
N2′-deacetyl-N2′-[3-[[1-[[4-[[(2,5-dioxo-1-pyrrolidinyl)oxy]carbonyl]cyclohexyl]methyl]-2,5-dioxo-3-pyrrolidinyl]thio]-1-oxopropyl]-maytansine DM1-SMCC is a cleavable linker-based antibody-drug conjugate (ADC) containing the maytansinoid DM1 (mertansine; Item No. 22483) and the crosslinker SMCC.{35225,35224} ADCs target specific cell populations to induce a selective response, such as cell death in cancer cells. DM1-SMCC conjugated to an anti-CD70 antibody has been used to study the transport of the ADC catabolites into the cell cytoplasm of 786-0 renal cell carcinoma cells.
Brand:CaymanSKU:23926 - 10 mgAvailable on backorder
N2′-deacetyl-N2′-[3-[[1-[[4-[[(2,5-dioxo-1-pyrrolidinyl)oxy]carbonyl]cyclohexyl]methyl]-2,5-dioxo-3-pyrrolidinyl]thio]-1-oxopropyl]-maytansine DM1-SMCC is a cleavable linker-based antibody-drug conjugate (ADC) containing the maytansinoid DM1 (mertansine; Item No. 22483) and the crosslinker SMCC.{35225,35224} ADCs target specific cell populations to induce a selective response, such as cell death in cancer cells. DM1-SMCC conjugated to an anti-CD70 antibody has been used to study the transport of the ADC catabolites into the cell cytoplasm of 786-0 renal cell carcinoma cells.
Brand:CaymanSKU:23926 - 25 mgAvailable on backorder
N2′-deacetyl-N2′-[3-[[1-[[4-[[(2,5-dioxo-1-pyrrolidinyl)oxy]carbonyl]cyclohexyl]methyl]-2,5-dioxo-3-pyrrolidinyl]thio]-1-oxopropyl]-maytansine DM1-SMCC is a cleavable linker-based antibody-drug conjugate (ADC) containing the maytansinoid DM1 (mertansine; Item No. 22483) and the crosslinker SMCC.{35225,35224} ADCs target specific cell populations to induce a selective response, such as cell death in cancer cells. DM1-SMCC conjugated to an anti-CD70 antibody has been used to study the transport of the ADC catabolites into the cell cytoplasm of 786-0 renal cell carcinoma cells.
Brand:CaymanSKU:23926 - 5 mgAvailable on backorder
DM1-SMe is an analog of mertansine (DM1; Item No. 22483) with a thiomethane cap attached to the sulfhydryl group.{40725} It has in vitro activity against the pediatric preclinical testing program (PPTP) panel of cancer cell lines with IC50 values of 0.002 to >3 nM.
Brand:CaymanSKU:22477 -Out of stock
DM1-SMe is an analog of mertansine (DM1; Item No. 22483) with a thiomethane cap attached to the sulfhydryl group.{40725} It has in vitro activity against the pediatric preclinical testing program (PPTP) panel of cancer cell lines with IC50 values of 0.002 to >3 nM.
Brand:CaymanSKU:22477 -Out of stock
DM1-SMe is an analog of mertansine (DM1; Item No. 22483) with a thiomethane cap attached to the sulfhydryl group.{40725} It has in vitro activity against the pediatric preclinical testing program (PPTP) panel of cancer cell lines with IC50 values of 0.002 to >3 nM.
Brand:CaymanSKU:22477 -Out of stock
DM1-SMe is an analog of mertansine (DM1; Item No. 22483) with a thiomethane cap attached to the sulfhydryl group.{40725} It has in vitro activity against the pediatric preclinical testing program (PPTP) panel of cancer cell lines with IC50 values of 0.002 to >3 nM.
Brand:CaymanSKU:22477 -Out of stock
DMA is a bisbenzimidazole radioprotective agent.{49648,49649} In vivo, DMA (300 mg/kg) decreases radiation-induced lethality without affecting radiation-induced tumor regression in an Ehrlich murine spontaneous adenocarcinoma model.{49648} It prevents radiation-induced damage of intestinal, hepatic, and splenic tissues, increases in splenic malondialdehyde (MDA) production, and decreases in splenic superoxide dismutase (SOD) activity in a B16/F10 murine melanoma model when administered at a dose of 50 mg/kg.{49649}
Brand:CaymanSKU:30416 - 1 mgAvailable on backorder
DMA is a bisbenzimidazole radioprotective agent.{49648,49649} In vivo, DMA (300 mg/kg) decreases radiation-induced lethality without affecting radiation-induced tumor regression in an Ehrlich murine spontaneous adenocarcinoma model.{49648} It prevents radiation-induced damage of intestinal, hepatic, and splenic tissues, increases in splenic malondialdehyde (MDA) production, and decreases in splenic superoxide dismutase (SOD) activity in a B16/F10 murine melanoma model when administered at a dose of 50 mg/kg.{49649}
Brand:CaymanSKU:30416 - 10 mgAvailable on backorder
DMA is a bisbenzimidazole radioprotective agent.{49648,49649} In vivo, DMA (300 mg/kg) decreases radiation-induced lethality without affecting radiation-induced tumor regression in an Ehrlich murine spontaneous adenocarcinoma model.{49648} It prevents radiation-induced damage of intestinal, hepatic, and splenic tissues, increases in splenic malondialdehyde (MDA) production, and decreases in splenic superoxide dismutase (SOD) activity in a B16/F10 murine melanoma model when administered at a dose of 50 mg/kg.{49649}
Brand:CaymanSKU:30416 - 5 mgAvailable on backorder
Phosphatidylethanolamine (PE) lipids are important components of cell membranes and biochemical pathways of fatty acid synthesis that contain abundant polyunsaturated fatty acyl (PUFA) groups. Oxidation of these phospholipids may be linked to various human diseases. DMABA NHS ester is a reagent that reacts with the primary amine group of PE lipids.{20256,20365} This facilitates the use of electrospray tandem mass spectrometry for the detection of diacyl, ether, and plasmalogen PE lipids that cannot be readily observed otherwise.{20256,20365} DMABA NHS ester has been used in combination with DMABA NHS ester-d4, -d6, and -d10 (Item Nos. 11217, 11218, and 11219) to study relative changes in PE lipid abundance before and after radical oxidation.{20365}
Brand:CaymanSKU:11216 - 100 mgAvailable on backorder
Phosphatidylethanolamine (PE) lipids are important components of cell membranes and biochemical pathways of fatty acid synthesis that contain abundant polyunsaturated fatty acyl (PUFA) groups. Oxidation of these phospholipids may be linked to various human diseases. DMABA NHS ester is a reagent that reacts with the primary amine group of PE lipids.{20256,20365} This facilitates the use of electrospray tandem mass spectrometry for the detection of diacyl, ether, and plasmalogen PE lipids that cannot be readily observed otherwise.{20256,20365} DMABA NHS ester has been used in combination with DMABA NHS ester-d4, -d6, and -d10 (Item Nos. 11217, 11218, and 11219) to study relative changes in PE lipid abundance before and after radical oxidation.{20365}
Brand:CaymanSKU:11216 - 50 mgAvailable on backorder
Phosphatidylethanolamine (PE) lipids are important components of cell membranes and biochemical pathways of fatty acid synthesis that contain abundant polyunsaturated fatty acyl (PUFA) groups. Oxidation of these phospholipids may be linked to various human diseases. DMABA NHS ester is a reagent that reacts with the primary amine group of PE lipids.{20256,20365} This facilitates the use of electrospray tandem mass spectrometry for the detection of diacyl, ether, and plasmalogen PE lipids that cannot be readily observed otherwise.{20256,20365} DMABA NHS ester has been used in combination with DMABA NHS ester-d4, -d6, and -d10 (Item Nos. 11217, 11218, and 11219) to study relative changes in PE lipid abundance before and after radical oxidation.{20365}
Brand:CaymanSKU:11216 - 500 mgAvailable on backorder
DMABA-d10 NHS ester is intended for use in combination with DMABA NHS ester (Item No. 11216) as a derivatizing reagent for PE lipids in order to facilitate MS characterization and to quantify relative changes in their abundance. DMABA-d10 and DMABA NHS esters have been shown to facilitate the characterization of PE lipids via electrospray mass spectrometry by providing a common precursor ion scan for diacyl, ether, and plasmalogen PE lipids.{20256} Furthermore, application of split-and-pool methodology allows for relative changes in endogenous PE lipid levels between control and treated samples to be measured.{20365} Phosphatidylethanolamine (PE) lipids are important components of cell membranes and biochemical pathways of fatty acid synthesis that contain abundant polyunsaturated fatty acyl groups. Oxidation of these phospholipids may be linked to various human diseases. DMABA NHS ester is a reagent that reacts with the primary amine group of PE lipids.{20256,20365} This facilitates the use of electrospray tandem mass spectrometry for the detection of diacyl, ether, and plasmalogen PE lipids that cannot be readily observed otherwise.{20256,20365}
Brand:CaymanSKU:11219 - 1 mgAvailable on backorder
DMABA-d10 NHS ester is intended for use in combination with DMABA NHS ester (Item No. 11216) as a derivatizing reagent for PE lipids in order to facilitate MS characterization and to quantify relative changes in their abundance. DMABA-d10 and DMABA NHS esters have been shown to facilitate the characterization of PE lipids via electrospray mass spectrometry by providing a common precursor ion scan for diacyl, ether, and plasmalogen PE lipids.{20256} Furthermore, application of split-and-pool methodology allows for relative changes in endogenous PE lipid levels between control and treated samples to be measured.{20365} Phosphatidylethanolamine (PE) lipids are important components of cell membranes and biochemical pathways of fatty acid synthesis that contain abundant polyunsaturated fatty acyl groups. Oxidation of these phospholipids may be linked to various human diseases. DMABA NHS ester is a reagent that reacts with the primary amine group of PE lipids.{20256,20365} This facilitates the use of electrospray tandem mass spectrometry for the detection of diacyl, ether, and plasmalogen PE lipids that cannot be readily observed otherwise.{20256,20365}
Brand:CaymanSKU:11219 - 10 mgAvailable on backorder
DMABA-d10 NHS ester is intended for use in combination with DMABA NHS ester (Item No. 11216) as a derivatizing reagent for PE lipids in order to facilitate MS characterization and to quantify relative changes in their abundance. DMABA-d10 and DMABA NHS esters have been shown to facilitate the characterization of PE lipids via electrospray mass spectrometry by providing a common precursor ion scan for diacyl, ether, and plasmalogen PE lipids.{20256} Furthermore, application of split-and-pool methodology allows for relative changes in endogenous PE lipid levels between control and treated samples to be measured.{20365} Phosphatidylethanolamine (PE) lipids are important components of cell membranes and biochemical pathways of fatty acid synthesis that contain abundant polyunsaturated fatty acyl groups. Oxidation of these phospholipids may be linked to various human diseases. DMABA NHS ester is a reagent that reacts with the primary amine group of PE lipids.{20256,20365} This facilitates the use of electrospray tandem mass spectrometry for the detection of diacyl, ether, and plasmalogen PE lipids that cannot be readily observed otherwise.{20256,20365}
Brand:CaymanSKU:11219 - 5 mgAvailable on backorder
DMABA-d4 NHS ester is intended for use in combination with DMABA NHS ester (Item No. 11216) as a derivatizing reagent for PE lipids in order to facilitate MS characterization and to quantify relative changes in their abundance. DMABA-d4 and DMABA NHS esters have been shown to facilitate the characterization of PE lipids via electrospray mass spectrometry by providing a common precursor ion scan for diacyl, ether, and plasmalogen PE lipids.{20256} Furthermore, application of split-and-pool methodology allows for relative changes in endogenous PE lipid levels between control and treated samples to be measured.{20365} Phosphatidylethanolamine (PE) lipids are important components of cell membranes and biochemical pathways of fatty acid synthesis that contain abundant polyunsaturated fatty acyl groups. Oxidation of these phospholipids may be linked to various human diseases. DMABA NHS ester is a reagent that reacts with the primary amine group of PE lipids.{20256,20365} This facilitates the use of electrospray tandem mass spectrometry for the detection of diacyl, ether, and plasmalogen PE lipids that cannot be readily observed otherwise.{20256,20365}
Brand:CaymanSKU:11217 - 1 mgAvailable on backorder
DMABA-d4 NHS ester is intended for use in combination with DMABA NHS ester (Item No. 11216) as a derivatizing reagent for PE lipids in order to facilitate MS characterization and to quantify relative changes in their abundance. DMABA-d4 and DMABA NHS esters have been shown to facilitate the characterization of PE lipids via electrospray mass spectrometry by providing a common precursor ion scan for diacyl, ether, and plasmalogen PE lipids.{20256} Furthermore, application of split-and-pool methodology allows for relative changes in endogenous PE lipid levels between control and treated samples to be measured.{20365} Phosphatidylethanolamine (PE) lipids are important components of cell membranes and biochemical pathways of fatty acid synthesis that contain abundant polyunsaturated fatty acyl groups. Oxidation of these phospholipids may be linked to various human diseases. DMABA NHS ester is a reagent that reacts with the primary amine group of PE lipids.{20256,20365} This facilitates the use of electrospray tandem mass spectrometry for the detection of diacyl, ether, and plasmalogen PE lipids that cannot be readily observed otherwise.{20256,20365}
Brand:CaymanSKU:11217 - 10 mgAvailable on backorder
DMABA-d4 NHS ester is intended for use in combination with DMABA NHS ester (Item No. 11216) as a derivatizing reagent for PE lipids in order to facilitate MS characterization and to quantify relative changes in their abundance. DMABA-d4 and DMABA NHS esters have been shown to facilitate the characterization of PE lipids via electrospray mass spectrometry by providing a common precursor ion scan for diacyl, ether, and plasmalogen PE lipids.{20256} Furthermore, application of split-and-pool methodology allows for relative changes in endogenous PE lipid levels between control and treated samples to be measured.{20365} Phosphatidylethanolamine (PE) lipids are important components of cell membranes and biochemical pathways of fatty acid synthesis that contain abundant polyunsaturated fatty acyl groups. Oxidation of these phospholipids may be linked to various human diseases. DMABA NHS ester is a reagent that reacts with the primary amine group of PE lipids.{20256,20365} This facilitates the use of electrospray tandem mass spectrometry for the detection of diacyl, ether, and plasmalogen PE lipids that cannot be readily observed otherwise.{20256,20365}
Brand:CaymanSKU:11217 - 5 mgAvailable on backorder
DMABA-d6 NHS ester is intended for use in combination with DMABA NHS ester (Item No. 11216) as a derivatizing reagent for PE lipids in order to facilitate MS characterization and to quantify relative changes in their abundance. DMABA-d6 and DMABA NHS esters have been shown to facilitate the characterization of PE lipids via electrospray mass spectrometry by providing a common precursor ion scan for diacyl, ether, and plasmalogen PE lipids.{20256} Furthermore, application of split-and-pool methodology allows for relative changes in endogenous PE lipid levels between control and treated samples to be measured.{20365} Phosphatidylethanolamine (PE) lipids are important components of cell membranes and biochemical pathways of fatty acid synthesis that contain abundant polyunsaturated fatty acyl groups. Oxidation of these phospholipids may be linked to various human diseases. DMABA NHS ester is a reagent that reacts with the primary amine group of PE lipids.{20256,20365} This facilitates the use of electrospray tandem mass spectrometry for the detection of diacyl, ether, and plasmalogen PE lipids that cannot be readily observed otherwise.{20256,20365}
Brand:CaymanSKU:11218 - 1 mgAvailable on backorder
DMABA-d6 NHS ester is intended for use in combination with DMABA NHS ester (Item No. 11216) as a derivatizing reagent for PE lipids in order to facilitate MS characterization and to quantify relative changes in their abundance. DMABA-d6 and DMABA NHS esters have been shown to facilitate the characterization of PE lipids via electrospray mass spectrometry by providing a common precursor ion scan for diacyl, ether, and plasmalogen PE lipids.{20256} Furthermore, application of split-and-pool methodology allows for relative changes in endogenous PE lipid levels between control and treated samples to be measured.{20365} Phosphatidylethanolamine (PE) lipids are important components of cell membranes and biochemical pathways of fatty acid synthesis that contain abundant polyunsaturated fatty acyl groups. Oxidation of these phospholipids may be linked to various human diseases. DMABA NHS ester is a reagent that reacts with the primary amine group of PE lipids.{20256,20365} This facilitates the use of electrospray tandem mass spectrometry for the detection of diacyl, ether, and plasmalogen PE lipids that cannot be readily observed otherwise.{20256,20365}
Brand:CaymanSKU:11218 - 10 mgAvailable on backorder
DMABA-d6 NHS ester is intended for use in combination with DMABA NHS ester (Item No. 11216) as a derivatizing reagent for PE lipids in order to facilitate MS characterization and to quantify relative changes in their abundance. DMABA-d6 and DMABA NHS esters have been shown to facilitate the characterization of PE lipids via electrospray mass spectrometry by providing a common precursor ion scan for diacyl, ether, and plasmalogen PE lipids.{20256} Furthermore, application of split-and-pool methodology allows for relative changes in endogenous PE lipid levels between control and treated samples to be measured.{20365} Phosphatidylethanolamine (PE) lipids are important components of cell membranes and biochemical pathways of fatty acid synthesis that contain abundant polyunsaturated fatty acyl groups. Oxidation of these phospholipids may be linked to various human diseases. DMABA NHS ester is a reagent that reacts with the primary amine group of PE lipids.{20256,20365} This facilitates the use of electrospray tandem mass spectrometry for the detection of diacyl, ether, and plasmalogen PE lipids that cannot be readily observed otherwise.{20256,20365}
Brand:CaymanSKU:11218 - 5 mgAvailable on backorder
Dimethylallyl pyrophosphate and isopentyl pyrophosphate undergo condensation to yield geranyl pyrophosphate, which undergoes condensation with a second molecule of isopentyl pyrophosphate to yield farnesyl pyrophosphate.{6606,6607} Farnesylation is essential for the function of a number of proteins involved in signal transduction.{5456,2640}
Brand:CaymanSKU:63180 - 1 mgAvailable on backorder
Dimethylallyl pyrophosphate and isopentyl pyrophosphate undergo condensation to yield geranyl pyrophosphate, which undergoes condensation with a second molecule of isopentyl pyrophosphate to yield farnesyl pyrophosphate.{6606,6607} Farnesylation is essential for the function of a number of proteins involved in signal transduction.{5456,2640}
Brand:CaymanSKU:63180 - 10 mgAvailable on backorder
Dimethylallyl pyrophosphate and isopentyl pyrophosphate undergo condensation to yield geranyl pyrophosphate, which undergoes condensation with a second molecule of isopentyl pyrophosphate to yield farnesyl pyrophosphate.{6606,6607} Farnesylation is essential for the function of a number of proteins involved in signal transduction.{5456,2640}
Brand:CaymanSKU:63180 - 5 mgAvailable on backorder
Dimethylallyl pyrophosphate and isopentyl pyrophosphate undergo condensation to yield geranyl pyrophosphate, which undergoes condensation with a second molecule of isopentyl pyrophosphate to yield farnesyl pyrophosphate.{6606,6607} Farnesylation is essential for the function of a number of proteins involved in signal transduction.{5456,2640}
Brand:CaymanSKU:63180 - 500 µgAvailable on backorder
DMAT is a cell-permeable inhibitor of casein kinase 2 (CK2; IC50 = 0.13 µM).{22896} It also inhibits Pim-1, Pim-3, HIPK2, and HIPK3 (IC50s = 0.15, 0.097, 0.37, and 0.59 µM, respectively).{22896} DMAT blocks cell growth and induces cell death in cancer cells, both in culture and in mouse xenografts.{33787,33788,33789}
Brand:CaymanSKU:21182 -Out of stock