Cayman

Showing 17851–18000 of 45550 results

  • Desacetyl bisacodyl (DAB) is an active metabolite of two stimulant laxatives, bisacodyl and sodium picosulfate.{33526,33529} DAB evokes several effects at the colon or rectum, including increased mucus and chloride secretion.{33524,33525} Oral administration of bisacodyl leads to decreased expression of aquaporin-3 in the colon of rats.{33527} The effects of both DAB and bisacodyl can be blocked with cyclooxygenase (COX) inhibitors, suggesting that products of the COX signaling pathway contribute to laxative effects.{33525,33527}  

     

    Brand:
    Cayman
    SKU:20928 -

    Out of stock

  • Desacetyl cefapirin is an active metabolite of the cephalosporin antibiotic cefapirin (Item No. 17406).{43997} Desacetyl cefapirin is active against E. coli, K. pneumoniae, P. mirabilis, and S. aureus with MIC values of 120, 24, 34, and 0.42 µg/ml, respectively.  

     

    Brand:
    Cayman
    SKU:27578 - 1 mg

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  • Desacetyl cefapirin is an active metabolite of the cephalosporin antibiotic cefapirin (Item No. 17406).{43997} Desacetyl cefapirin is active against E. coli, K. pneumoniae, P. mirabilis, and S. aureus with MIC values of 120, 24, 34, and 0.42 µg/ml, respectively.  

     

    Brand:
    Cayman
    SKU:27578 - 10 mg

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  • Desacetyl cefapirin is an active metabolite of the cephalosporin antibiotic cefapirin (Item No. 17406).{43997} Desacetyl cefapirin is active against E. coli, K. pneumoniae, P. mirabilis, and S. aureus with MIC values of 120, 24, 34, and 0.42 µg/ml, respectively.  

     

    Brand:
    Cayman
    SKU:27578 - 25 mg

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  • Desacetyl cefapirin is an active metabolite of the cephalosporin antibiotic cefapirin (Item No. 17406).{43997} Desacetyl cefapirin is active against E. coli, K. pneumoniae, P. mirabilis, and S. aureus with MIC values of 120, 24, 34, and 0.42 µg/ml, respectively.  

     

    Brand:
    Cayman
    SKU:27578 - 5 mg

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  • Descarbamylnovobiocin is a derivative of novobiocin (Item No. 18457).{48883}  

     

    Brand:
    Cayman
    SKU:29971 - 1 mg

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  • Descarbamylnovobiocin is a derivative of novobiocin (Item No. 18457).{48883}  

     

    Brand:
    Cayman
    SKU:29971 - 5 mg

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  • deschloro-N-ethyl-Ketamine is an analog of the dissociative anesthetic ketamine (Item No. 11630). Ketamine and its analogs have been abused recreationally.{21236,21240,21237,25509} The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research purposes.  

     

    Brand:
    Cayman
    SKU:-
  • deschloro-N-ethyl-Ketamine is an analog of the dissociative anesthetic ketamine (Item No. 11630). Ketamine and its analogs have been abused recreationally.{21236,21240,21237,25509} The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research purposes.  

     

    Brand:
    Cayman
    SKU:-
  • deschloro-N-ethyl-Ketamine is an analog of the dissociative anesthetic ketamine (Item No. 11630). Ketamine and its analogs have been abused recreationally.{21236,21240,21237,25509} The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research purposes.  

     

    Brand:
    Cayman
    SKU:-
  • Deschloroetizolam (Item No. 23107) is an analytical reference standard categorized as a thienodiazepine.{35230} This product is intended for research and forensic applications.  

     

    Brand:
    Cayman
    SKU:23107 - 1 mg

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  • Deschloroetizolam (Item No. 23107) is an analytical reference standard categorized as a thienodiazepine.{35230} This product is intended for research and forensic applications.  

     

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    Cayman
    SKU:23107 - 5 mg

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  • Deschloronorketamine (hydrochloride) (Item No. 26401) is an analytical reference standard categorized as an arylcyclohexylamine. It is a metabolite of deschloroketamine (Item Nos. 25688 | 18683).{49018} This product is intended for research and forensic applications.  

     

    Brand:
    Cayman
    SKU:26401 - 1 mg

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  • Deschloronorketamine (hydrochloride) (Item No. 26401) is an analytical reference standard categorized as an arylcyclohexylamine. It is a metabolite of deschloroketamine (Item Nos. 25688 | 18683).{49018} This product is intended for research and forensic applications.  

     

    Brand:
    Cayman
    SKU:26401 - 5 mg

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  • Desertomycin A is fungal metabolite and the major component of the desertomycin antibiotic complex that has been found in S. flavofungini.{45261}  

     

    Brand:
    Cayman
    SKU:28169 - 1 mg

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  • Desertomycin A is fungal metabolite and the major component of the desertomycin antibiotic complex that has been found in S. flavofungini.{45261}  

     

    Brand:
    Cayman
    SKU:28169 - 5 mg

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  • Desethyl hydroxychloroquine is an active metabolite of hydroxychloroquine (Item No. 17911).{57098} It is formed via the desethylation of hydroxychloroquine in the liver, a process mediated by the cytochrome P450 (CYP) isoforms CYP2D6, CYP3A4, CYP3A5, and CYP2C8.  

     

    Brand:
    Cayman
    SKU:31152 - 1 mg

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  • Desethyl hydroxychloroquine-d4 is intended for use as an internal standard for the quantification of desethyl hydroxychloroquine (Item No. 31152) by GC- or LC-MS. Desethyl hydroxychloroquine is an active metabolite of hydroxychloroquine (Item No. 17911).{57098} It is formed via the desethylation of hydroxychloroquine in the liver, a process mediated by the cytochrome P450 (CYP) isoforms CYP2D6, CYP3A4, CYP3A5, and CYP2C8.  

     

    Brand:
    Cayman
    SKU:31162 - 1 mg

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  • Desethyl hydroxychloroquine-d4 is intended for use as an internal standard for the quantification of desethyl hydroxychloroquine (Item No. 31152) by GC- or LC-MS. Desethyl hydroxychloroquine is an active metabolite of hydroxychloroquine (Item No. 17911).{57098} It is formed via the desethylation of hydroxychloroquine in the liver, a process mediated by the cytochrome P450 (CYP) isoforms CYP2D6, CYP3A4, CYP3A5, and CYP2C8.  

     

    Brand:
    Cayman
    SKU:31162 - 5 mg

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  • Desethyl hydroxychloroquine-d4 is intended for use as an internal standard for the quantification of desethyl hydroxychloroquine (Item No. 31152) by GC- or LC-MS. Desethyl hydroxychloroquine is an active metabolite of hydroxychloroquine (Item No. 17911).{57098} It is formed via the desethylation of hydroxychloroquine in the liver, a process mediated by the cytochrome P450 (CYP) isoforms CYP2D6, CYP3A4, CYP3A5, and CYP2C8.  

     

    Brand:
    Cayman
    SKU:31162 - 500 µg

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  • Desethylchloroquine is a major active metabolite of chloroquine (Item No. 14194).{52376} Desethylchloroquine is formed when chloroquine undergoes dealkylation, primarily by the cytochrome P450 (CYP) isoforms CYP2C8 and CYP3A4 and to a lesser extent by CYP2D6. It inhibits the growth of the P. falciparum strain LA136 in vitro (IC50 = 9.9 ng/ml).{52377}  

     

    Brand:
    Cayman
    SKU:30113 - 1 mg

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  • Desethylchloroquine is a major active metabolite of chloroquine (Item No. 14194).{52376} Desethylchloroquine is formed when chloroquine undergoes dealkylation, primarily by the cytochrome P450 (CYP) isoforms CYP2C8 and CYP3A4 and to a lesser extent by CYP2D6. It inhibits the growth of the P. falciparum strain LA136 in vitro (IC50 = 9.9 ng/ml).{52377}  

     

    Brand:
    Cayman
    SKU:30113 - 10 mg

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  • Desethylchloroquine is a major active metabolite of chloroquine (Item No. 14194).{52376} Desethylchloroquine is formed when chloroquine undergoes dealkylation, primarily by the cytochrome P450 (CYP) isoforms CYP2C8 and CYP3A4 and to a lesser extent by CYP2D6. It inhibits the growth of the P. falciparum strain LA136 in vitro (IC50 = 9.9 ng/ml).{52377}  

     

    Brand:
    Cayman
    SKU:30113 - 5 mg

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  • Desethylchloroquine-d4 is intended for use as an internal standard for the quantification of desethylchloroquine (Item No. 30113) by GC- or LC-MS. Desethylchloroquine is a major active metabolite of chloroquine (Item No. 14194).{52376} Desethylchloroquine is formed when chloroquine undergoes dealkylation, primarily by the cytochrome P450 (CYP) isoforms CYP2C8 and CYP3A4 and to a lesser extent by CYP2D6. It inhibits the growth of the P. falciparum strain LA136 in vitro (IC50 = 9.9 ng/ml).{52377}  

     

    Brand:
    Cayman
    SKU:30907 - 1 mg

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  • Desethylene ciprofloxacin is a major metabolite of ciprofloxacin (Item No. 14286).{38229} It is also a degradation product of ciprofloxacin that can be created through advanced oxygenation processes as a potential way to remove ciprofloxacin from wastewater.{38230} It is also created during degradation of ciprofloxacin by chlorination.{38231}  

     

    Brand:
    Cayman
    SKU:22123 -

    Out of stock

  • Desethylene ciprofloxacin is a major metabolite of ciprofloxacin (Item No. 14286).{38229} It is also a degradation product of ciprofloxacin that can be created through advanced oxygenation processes as a potential way to remove ciprofloxacin from wastewater.{38230} It is also created during degradation of ciprofloxacin by chlorination.{38231}  

     

    Brand:
    Cayman
    SKU:22123 -

    Out of stock

  • Desethylene ciprofloxacin is a major metabolite of ciprofloxacin (Item No. 14286).{38229} It is also a degradation product of ciprofloxacin that can be created through advanced oxygenation processes as a potential way to remove ciprofloxacin from wastewater.{38230} It is also created during degradation of ciprofloxacin by chlorination.{38231}  

     

    Brand:
    Cayman
    SKU:22123 -

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  • Desidustat is an inhibitor of prolyl hydroxylase (PHD).{52044} It reduces levels of hypoxia-inducible factor-1α (HIF-1α), a transcription factor regulated by PHD enzymes, in rat liver and kidney. Desidustat increases the expression of the red blood cell- and iron transport-related genes Epo, Fpn1, and Hamp in rat liver in a model of anemia induced by peptidoglycan-polysaccharide (PGPS).{52045} It increases plasma levels of erythropoietin in rats by 10.3- to 40-fold when administered at doses of 15 and 30 mg/kg, respectively.{52044} Desidustat (15 and 30 mg/kg) also increases plasma levels of erythropoietin and hemoglobin, as well as the number of circulating red blood cells, in nephrectomized rats in a model of chronic kidney disease-induced anemia. It increases hemoglobin levels and the number of circulating red blood cells in a mouse model of anemia induced by the DNA-crosslinking agent cisplatin (Item No. 13119).  

     

    Brand:
    Cayman
    SKU:28074 - 10 mg

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  • Desidustat is an inhibitor of prolyl hydroxylase (PHD).{52044} It reduces levels of hypoxia-inducible factor-1α (HIF-1α), a transcription factor regulated by PHD enzymes, in rat liver and kidney. Desidustat increases the expression of the red blood cell- and iron transport-related genes Epo, Fpn1, and Hamp in rat liver in a model of anemia induced by peptidoglycan-polysaccharide (PGPS).{52045} It increases plasma levels of erythropoietin in rats by 10.3- to 40-fold when administered at doses of 15 and 30 mg/kg, respectively.{52044} Desidustat (15 and 30 mg/kg) also increases plasma levels of erythropoietin and hemoglobin, as well as the number of circulating red blood cells, in nephrectomized rats in a model of chronic kidney disease-induced anemia. It increases hemoglobin levels and the number of circulating red blood cells in a mouse model of anemia induced by the DNA-crosslinking agent cisplatin (Item No. 13119).  

     

    Brand:
    Cayman
    SKU:28074 - 100 mg

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  • Desidustat is an inhibitor of prolyl hydroxylase (PHD).{52044} It reduces levels of hypoxia-inducible factor-1α (HIF-1α), a transcription factor regulated by PHD enzymes, in rat liver and kidney. Desidustat increases the expression of the red blood cell- and iron transport-related genes Epo, Fpn1, and Hamp in rat liver in a model of anemia induced by peptidoglycan-polysaccharide (PGPS).{52045} It increases plasma levels of erythropoietin in rats by 10.3- to 40-fold when administered at doses of 15 and 30 mg/kg, respectively.{52044} Desidustat (15 and 30 mg/kg) also increases plasma levels of erythropoietin and hemoglobin, as well as the number of circulating red blood cells, in nephrectomized rats in a model of chronic kidney disease-induced anemia. It increases hemoglobin levels and the number of circulating red blood cells in a mouse model of anemia induced by the DNA-crosslinking agent cisplatin (Item No. 13119).  

     

    Brand:
    Cayman
    SKU:28074 - 50 mg

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  • Deslanoside is a cardiac glycoside that has been found in D. lanata.{54296} It induces ventricular tachycardia in anesthetized dogs when administered intravenously at a dose of 0.18 mg/kg.{54297} Formulations containing deslanoside have been used in the treatment of congestive heart failure and cardiac arrythmias.  

     

    Brand:
    Cayman
    SKU:30872 - 1 mg

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  • Deslanoside is a cardiac glycoside that has been found in D. lanata.{54296} It induces ventricular tachycardia in anesthetized dogs when administered intravenously at a dose of 0.18 mg/kg.{54297} Formulations containing deslanoside have been used in the treatment of congestive heart failure and cardiac arrythmias.  

     

    Brand:
    Cayman
    SKU:30872 - 10 mg

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  • Deslanoside is a cardiac glycoside that has been found in D. lanata.{54296} It induces ventricular tachycardia in anesthetized dogs when administered intravenously at a dose of 0.18 mg/kg.{54297} Formulations containing deslanoside have been used in the treatment of congestive heart failure and cardiac arrythmias.  

     

    Brand:
    Cayman
    SKU:30872 - 25 mg

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  • Deslanoside is a cardiac glycoside that has been found in D. lanata.{54296} It induces ventricular tachycardia in anesthetized dogs when administered intravenously at a dose of 0.18 mg/kg.{54297} Formulations containing deslanoside have been used in the treatment of congestive heart failure and cardiac arrythmias.  

     

    Brand:
    Cayman
    SKU:30872 - 5 mg

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  • Desloratadine is the orally active metabolite of the non-sedating antihistamine loratadine (Item No. 15625). It is a tricyclic antagonist of the histamine H1 receptor (Ki = 0.97 nM).{27482,27483} Its use in vivo features long duration of action with minimal sedation.{27483} Although studies indicate that desloratadine antagonizes muscarinic receptors, it has limited effects on peripheral muscarinic receptors in vivo and consequently minimally impacts xerostomia and dry eyes at therapeutic concentrations.{27481}  

     

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    Cayman
    SKU:-

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  • Desloratadine is the orally active metabolite of the non-sedating antihistamine loratadine (Item No. 15625). It is a tricyclic antagonist of the histamine H1 receptor (Ki = 0.97 nM).{27482,27483} Its use in vivo features long duration of action with minimal sedation.{27483} Although studies indicate that desloratadine antagonizes muscarinic receptors, it has limited effects on peripheral muscarinic receptors in vivo and consequently minimally impacts xerostomia and dry eyes at therapeutic concentrations.{27481}  

     

    Brand:
    Cayman
    SKU:-

    Out of stock

  • Desloratadine is the orally active metabolite of the non-sedating antihistamine loratadine (Item No. 15625). It is a tricyclic antagonist of the histamine H1 receptor (Ki = 0.97 nM).{27482,27483} Its use in vivo features long duration of action with minimal sedation.{27483} Although studies indicate that desloratadine antagonizes muscarinic receptors, it has limited effects on peripheral muscarinic receptors in vivo and consequently minimally impacts xerostomia and dry eyes at therapeutic concentrations.{27481}  

     

    Brand:
    Cayman
    SKU:-

    Out of stock

  • Desloratadine is the orally active metabolite of the non-sedating antihistamine loratadine (Item No. 15625). It is a tricyclic antagonist of the histamine H1 receptor (Ki = 0.97 nM).{27482,27483} Its use in vivo features long duration of action with minimal sedation.{27483} Although studies indicate that desloratadine antagonizes muscarinic receptors, it has limited effects on peripheral muscarinic receptors in vivo and consequently minimally impacts xerostomia and dry eyes at therapeutic concentrations.{27481}  

     

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    Cayman
    SKU:-

    Out of stock

  • Desmethyl erlotinib is a metabolite of erlotinib (Item No. 10483).{40416} Erlotinib is a tyrosine kinase inhibitor which acts on the epidermal growth factor receptor (EGFR), inhibiting EGFR-associated kinase activity (IC50 = 2.5 µM).{18354,18362} This inhibits tumor growth in human head and neck carcinoma HN5 tumor xenografts in mice with an ED50 value of 9 mg/kg.{18354} Erlotinib also suppresses cyclin-dependent kinase 2 (Cdk2) activity in breast cancer cells (IC50 = 4.6 µM) and JAK2 mutant JAK2V617F positive hematopoietic progenitor cells (IC50 = 5 µM), which is associated with polycythemia vera, idiopathic myelofibrosis, and essential thrombocythemia.{16061,18355} Formulations containing erlotinib have been used to treat certain forms of cancer, including non-small cell lung cancer.{18351,17857}  

     

    Brand:
    Cayman
    SKU:23394 - 1 mg

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  • Desmethyl erlotinib is a metabolite of erlotinib (Item No. 10483).{40416} Erlotinib is a tyrosine kinase inhibitor which acts on the epidermal growth factor receptor (EGFR), inhibiting EGFR-associated kinase activity (IC50 = 2.5 µM).{18354,18362} This inhibits tumor growth in human head and neck carcinoma HN5 tumor xenografts in mice with an ED50 value of 9 mg/kg.{18354} Erlotinib also suppresses cyclin-dependent kinase 2 (Cdk2) activity in breast cancer cells (IC50 = 4.6 µM) and JAK2 mutant JAK2V617F positive hematopoietic progenitor cells (IC50 = 5 µM), which is associated with polycythemia vera, idiopathic myelofibrosis, and essential thrombocythemia.{16061,18355} Formulations containing erlotinib have been used to treat certain forms of cancer, including non-small cell lung cancer.{18351,17857}  

     

    Brand:
    Cayman
    SKU:23394 - 10 mg

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  • Desmethyl erlotinib is a metabolite of erlotinib (Item No. 10483).{40416} Erlotinib is a tyrosine kinase inhibitor which acts on the epidermal growth factor receptor (EGFR), inhibiting EGFR-associated kinase activity (IC50 = 2.5 µM).{18354,18362} This inhibits tumor growth in human head and neck carcinoma HN5 tumor xenografts in mice with an ED50 value of 9 mg/kg.{18354} Erlotinib also suppresses cyclin-dependent kinase 2 (Cdk2) activity in breast cancer cells (IC50 = 4.6 µM) and JAK2 mutant JAK2V617F positive hematopoietic progenitor cells (IC50 = 5 µM), which is associated with polycythemia vera, idiopathic myelofibrosis, and essential thrombocythemia.{16061,18355} Formulations containing erlotinib have been used to treat certain forms of cancer, including non-small cell lung cancer.{18351,17857}  

     

    Brand:
    Cayman
    SKU:23394 - 5 mg

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  • Desmethylcitalopram (hydrochloride) (Item No. 15905) is an analytical reference standard that is an active metabolite of citalopram (Item Nos. 23252 | 14572).{37245} This product is intended for research and forensic applications.  

     

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    Cayman
    SKU:-
  • Desmethylcitalopram (hydrochloride) (Item No. 15905) is an analytical reference standard that is an active metabolite of citalopram (Item Nos. 23252 | 14572).{37245} This product is intended for research and forensic applications.  

     

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    Cayman
    SKU:-
  • Desmethylcitalopram-d3 (hydrochloride) (Item No. 15840) is an analytical reference standard intended for use as an internal standard for the quantification of desmethylcitalopram (Item No. 15905) by GC- or LC-MS. Desmethylcitalopram is an active metabolite of citalopram (Item Nos. 23252 | 14572).{37245} This product is intended for research and forensic applications.  

     

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    Cayman
    SKU:-
  • Desmethylcitalopram-d3 (hydrochloride) (Item No. 15840) is an analytical reference standard intended for use as an internal standard for the quantification of desmethylcitalopram (Item No. 15905) by GC- or LC-MS. Desmethylcitalopram is an active metabolite of citalopram (Item Nos. 23252 | 14572).{37245} This product is intended for research and forensic applications.  

     

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    Cayman
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  • Desmethylclotiazepam (Item No. 27838) is an analytical reference standard categorized as a thienodiazepine.{48303} It is an active metabolite of clotiazepam.{48304} This product is intended for research and forensic applications.  

     

    Brand:
    Cayman
    SKU:27838 - 1 mg

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  • Desmethylclotiazepam (Item No. 27838) is an analytical reference standard categorized as a thienodiazepine.{48303} It is an active metabolite of clotiazepam.{48304} This product is intended for research and forensic applications.  

     

    Brand:
    Cayman
    SKU:27838 - 5 mg

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  • Doxepin (Item No. 15888) is a tricyclic antidepressant. Desmethyldoxepin is the primary metabolite of doxepin, produced by metabolism at the liver.{26038,26037} The metabolism of tricyclic antidepressants, including doxepin, is affected by a variety of factors, including age, genetics, and drug-drug interactions.{26039}  

     

    Brand:
    Cayman
    SKU:-
  • Doxepin (Item No. 15888) is a tricyclic antidepressant. Desmethyldoxepin is the primary metabolite of doxepin, produced by metabolism at the liver.{26038,26037} The metabolism of tricyclic antidepressants, including doxepin, is affected by a variety of factors, including age, genetics, and drug-drug interactions.{26039}  

     

    Brand:
    Cayman
    SKU:-
  • Doxepin (Item No. 15888) is a tricyclic antidepressant. Desmethyldoxepin is the primary metabolite of doxepin, produced by metabolism at the liver.{26038,26037} The metabolism of tricyclic antidepressants, including doxepin, is affected by a variety of factors, including age, genetics, and drug-drug interactions.{26039}  

     

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    Cayman
    SKU:-
  • Paroxetine (Item No. 14998) is a potent, selective serotonin reuptake inhibitor (Ki = 0.72 nM) that has been used in cases of depression and anxiety disorder.{24255,23626,23628} Desmethylene paroxetine is a major urinary metabolite of paroxetine.{26062,26063} This compound may be used in urine drug testing applications involving paroxetine toxicology or forensic analysis.  

     

    Brand:
    Cayman
    SKU:-
  • Paroxetine (Item No. 14998) is a potent, selective serotonin reuptake inhibitor (Ki = 0.72 nM) that has been used in cases of depression and anxiety disorder.{24255,23626,23628} Desmethylene paroxetine is a major urinary metabolite of paroxetine.{26062,26063} This compound may be used in urine drug testing applications involving paroxetine toxicology or forensic analysis.  

     

    Brand:
    Cayman
    SKU:-
  • Paroxetine (Item No. 14998) is a potent, selective serotonin reuptake inhibitor (Ki = 0.72 nM) that has been used in cases of depression and anxiety disorder.{24255,23626,23628} Desmethylene paroxetine is a major urinary metabolite of paroxetine.{26062,26063} This compound may be used in urine drug testing applications involving paroxetine toxicology or forensic analysis.  

     

    Brand:
    Cayman
    SKU:-
  • Desmopressin is a synthetic version of the endogenous antidiuretic hormone arginine vasopressin (AVP). Compared to AVP, the first amino acid of desmopressin has been deaminated, and the arginine at the eighth position is in the dextrorotatory rather than the levorotatory form. Desmopressin acts as an agonist at human vasopressin V1a, V1b, and V2 receptors with Ki values of 62.4, 5.8, and 23.3 nM, respectively.{28407}  

     

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    Cayman
    SKU:-

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  • Desmopressin is a synthetic version of the endogenous antidiuretic hormone arginine vasopressin (AVP). Compared to AVP, the first amino acid of desmopressin has been deaminated, and the arginine at the eighth position is in the dextrorotatory rather than the levorotatory form. Desmopressin acts as an agonist at human vasopressin V1a, V1b, and V2 receptors with Ki values of 62.4, 5.8, and 23.3 nM, respectively.{28407}  

     

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    Cayman
    SKU:-

    Available on backorder

  • Desmopressin is a synthetic version of the endogenous antidiuretic hormone arginine vasopressin (AVP). Compared to AVP, the first amino acid of desmopressin has been deaminated, and the arginine at the eighth position is in the dextrorotatory rather than the levorotatory form. Desmopressin acts as an agonist at human vasopressin V1a, V1b, and V2 receptors with Ki values of 62.4, 5.8, and 23.3 nM, respectively.{28407}  

     

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    Cayman
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  • Desogestrel is a synthetic progestogen.{41180} It inhibits ovulation and prevents fertilization in rabbits and mice. Desogestrel inhibits rhodamine123 efflux, a measure of P-glycoprotein activity, ex vivo in human lymphocytes and CD8+ T cells in a dose-dependent manner.{41181} Formulations containing desogestrel have been used as oral contraceptives and for the treatment of polycystic ovary syndrome.{41181,41182}  

     

    Brand:
    Cayman
    SKU:23651 - 10 mg

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  • Desogestrel is a synthetic progestogen.{41180} It inhibits ovulation and prevents fertilization in rabbits and mice. Desogestrel inhibits rhodamine123 efflux, a measure of P-glycoprotein activity, ex vivo in human lymphocytes and CD8+ T cells in a dose-dependent manner.{41181} Formulations containing desogestrel have been used as oral contraceptives and for the treatment of polycystic ovary syndrome.{41181,41182}  

     

    Brand:
    Cayman
    SKU:23651 - 25 mg

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  • Desogestrel is a synthetic progestogen.{41180} It inhibits ovulation and prevents fertilization in rabbits and mice. Desogestrel inhibits rhodamine123 efflux, a measure of P-glycoprotein activity, ex vivo in human lymphocytes and CD8+ T cells in a dose-dependent manner.{41181} Formulations containing desogestrel have been used as oral contraceptives and for the treatment of polycystic ovary syndrome.{41181,41182}  

     

    Brand:
    Cayman
    SKU:23651 - 5 mg

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  • Desomorphine is a morphine derivative in which the 6-hydroxyl group and the 7,8 double bond have been reduced. Compared to morphine, it demonstrates similar opioid-like effects with rapid onset, 10 times greater potency, and short duration of action.{26029} This product is intended for forensic and research applications.  

     

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    Cayman
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  • Desonide is a synthetic corticosteroid.{33620} It is a nonfluorinated analog of triamcinolone acetonide (Item No. 18026). Formulations containing desonide are used topically to reduce inflammation in conditions that include allergic reactions and psoriasis.{33620,33619}  

     

    Brand:
    Cayman
    SKU:21368 -

    Out of stock

  • Desonide is a synthetic corticosteroid.{33620} It is a nonfluorinated analog of triamcinolone acetonide (Item No. 18026). Formulations containing desonide are used topically to reduce inflammation in conditions that include allergic reactions and psoriasis.{33620,33619}  

     

    Brand:
    Cayman
    SKU:21368 -

    Out of stock

  • Desonide is a synthetic corticosteroid.{33620} It is a nonfluorinated analog of triamcinolone acetonide (Item No. 18026). Formulations containing desonide are used topically to reduce inflammation in conditions that include allergic reactions and psoriasis.{33620,33619}  

     

    Brand:
    Cayman
    SKU:21368 -

    Out of stock

  • Desonide is a synthetic corticosteroid.{33620} It is a nonfluorinated analog of triamcinolone acetonide (Item No. 18026). Formulations containing desonide are used topically to reduce inflammation in conditions that include allergic reactions and psoriasis.{33620,33619}  

     

    Brand:
    Cayman
    SKU:21368 -

    Out of stock

  • Desotamide is a cyclic hexapeptide antibiotic originally isolated from Streptomyces.{49165} It is active against S. aureus, S. pneumoniae, and methicillin-resistant S. epidermidis (MRSE; MICs = 16, 12.5, and 32 μg/ml, respectively).{49166}  

     

    Brand:
    Cayman
    SKU:28129 - 2.5 mg

    Available on backorder

  • Desotamide is a cyclic hexapeptide antibiotic originally isolated from Streptomyces.{49165} It is active against S. aureus, S. pneumoniae, and methicillin-resistant S. epidermidis (MRSE; MICs = 16, 12.5, and 32 μg/ml, respectively).{49166}  

     

    Brand:
    Cayman
    SKU:28129 - 500 µg

    Available on backorder

  • Desoximetasone is a glucocorticoid.{39559} In vivo, desoximetasone (0.001-0.1 mg) reverses increases in epidermal cell proliferation induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in SENCAR mice when administered topically. It also reduces TPA-induced expression of IL-6, COX-2, iNOS, and c-Jun mRNA levels in the skin of SENCAR mice, indicating anti-inflammatory action. Formulations containing desoximetasone have been used in the treatment of psoriasis and atopic dermatitis.  

     

    Brand:
    Cayman
    SKU:23945 - 1 mg

    Available on backorder

  • Desoximetasone is a glucocorticoid.{39559} In vivo, desoximetasone (0.001-0.1 mg) reverses increases in epidermal cell proliferation induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in SENCAR mice when administered topically. It also reduces TPA-induced expression of IL-6, COX-2, iNOS, and c-Jun mRNA levels in the skin of SENCAR mice, indicating anti-inflammatory action. Formulations containing desoximetasone have been used in the treatment of psoriasis and atopic dermatitis.  

     

    Brand:
    Cayman
    SKU:23945 - 10 mg

    Available on backorder

  • Desoximetasone is a glucocorticoid.{39559} In vivo, desoximetasone (0.001-0.1 mg) reverses increases in epidermal cell proliferation induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in SENCAR mice when administered topically. It also reduces TPA-induced expression of IL-6, COX-2, iNOS, and c-Jun mRNA levels in the skin of SENCAR mice, indicating anti-inflammatory action. Formulations containing desoximetasone have been used in the treatment of psoriasis and atopic dermatitis.  

     

    Brand:
    Cayman
    SKU:23945 - 5 mg

    Available on backorder

  • Desoximetasone is a glucocorticoid.{39559} In vivo, desoximetasone (0.001-0.1 mg) reverses increases in epidermal cell proliferation induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in SENCAR mice when administered topically. It also reduces TPA-induced expression of IL-6, COX-2, iNOS, and c-Jun mRNA levels in the skin of SENCAR mice, indicating anti-inflammatory action. Formulations containing desoximetasone have been used in the treatment of psoriasis and atopic dermatitis.  

     

    Brand:
    Cayman
    SKU:23945 - 50 mg

    Available on backorder

  • Despropionyl meta-chlorofentanyl (Item No. 32506) is an analytical reference standard that is structurally similar to known opioids. This product is intended for research and forensic applications.  

     

    Brand:
    Cayman
    SKU:32506 - 1 mg

    Available on backorder

  • Despropionyl meta-chlorofentanyl (Item No. 32506) is an analytical reference standard that is structurally similar to known opioids. This product is intended for research and forensic applications.  

     

    Brand:
    Cayman
    SKU:32506 - 5 mg

    Available on backorder

  • Despropionyl meta-Methylfentanyl (Item No. 25744) is an analytical reference standard that is structurally similar to known opioids. This product is intended for research and forensic applications.  

     

    Brand:
    Cayman
    SKU:25744 - 1 mg

    Available on backorder

  • Despropionyl meta-Methylfentanyl (Item No. 25744) is an analytical reference standard that is structurally similar to known opioids. This product is intended for research and forensic applications.  

     

    Brand:
    Cayman
    SKU:25744 - 5 mg

    Available on backorder

  • Despropionyl ortho-methylfentanyl (Item No. 24279) is an analytical reference standard that is structurally similar to known opioids. It is a presumptive metabolite of ortho-methylfentanyl (Item No. 22634), ortho-methyl furanyl fentanyl (Item Nos. 22806 | 22779), ortho-methyl cyclopropyl fentanyl (Item No. 23043), ortho-methyl acetyl fentanyl (Item No. 23548), ortho-methyl phenyl fentanyl (Item No. 23652), ortho-methyl acrylfentanyl (Item No. 23036), and ortho-methyl methoxyacetyl fentanyl (Item No. 22977). This product is intended for research and forensic applications.  

     

    Brand:
    Cayman
    SKU:24279 - 1 mg

    Available on backorder

  • Despropionyl ortho-methylfentanyl (Item No. 24279) is an analytical reference standard that is structurally similar to known opioids. It is a presumptive metabolite of ortho-methylfentanyl (Item No. 22634), ortho-methyl furanyl fentanyl (Item Nos. 22806 | 22779), ortho-methyl cyclopropyl fentanyl (Item No. 23043), ortho-methyl acetyl fentanyl (Item No. 23548), ortho-methyl phenyl fentanyl (Item No. 23652), ortho-methyl acrylfentanyl (Item No. 23036), and ortho-methyl methoxyacetyl fentanyl (Item No. 22977). This product is intended for research and forensic applications.  

     

    Brand:
    Cayman
    SKU:24279 - 5 mg

    Available on backorder

  • Despropionyl para-methylfentanyl (Item No. 25745) is an analytical reference standard that is structurally similar to known opioids. This product is intended for research and forensic applications.  

     

    Brand:
    Cayman
    SKU:25745 - 1 mg

    Available on backorder

  • Despropionyl para-methylfentanyl (Item No. 25745) is an analytical reference standard that is structurally similar to known opioids. This product is intended for research and forensic applications.  

     

    Brand:
    Cayman
    SKU:25745 - 5 mg

    Available on backorder

  • Despropionyl remifentanil (Item No. 9003390) is an analytical reference standard that is structurally similar to known opioids. It is a precursor in the synthesis of remifentanil (Item Nos. 22429 | 19291). This product is intended for research and forensic applications.  

     

    Brand:
    Cayman
    SKU:9003390 - 1 mg

    Available on backorder

  • Despropionyl remifentanil (Item No. 9003390) is an analytical reference standard that is structurally similar to known opioids. It is a precursor in the synthesis of remifentanil (Item Nos. 22429 | 19291). This product is intended for research and forensic applications.  

     

    Brand:
    Cayman
    SKU:9003390 - 5 mg

    Available on backorder

  • Destruxin A is a cyclic hexadepsipeptide mycotoxin first isolated from O. destructor and commonly found in entomopathogenic fungi.{31992} It has insecticidal activity by affecting diverse pathways, including those related to immune response, calcium signaling, and development.{31990,31991}  

     

    Brand:
    Cayman
    SKU:20428 -

    Available on backorder

  • Destruxin B is a cyclic hexadepsipeptide mycotoxin first isolated from O. destructor.{31992} It has insecticidal and phytotoxic activity and is prone to metabolization by plants.{29047,31993} Destruxin B also induces apoptosis in human non-small cell lung cancer cells in culture.{31994}  

     

    Brand:
    Cayman
    SKU:20429 -

    Available on backorder

  • Destruxin B2 is a cyclic hexadepsipeptide mycotoxin that has been found in M. anisopliae and has antiviral, insecticidal, and phytotoxic activities.{48805,48806,48807} It inhibits secretion of hepatitis B virus surface antigen (HBsAg) by Hep3B cells expressing hepatitis B virus (HBV) DNA (IC50 = 1.3 µM).{48805} Destruxin B2 is toxic to Sf9 insect cells in an electric cell-substrate impedance sensing (ECIS) test with a 50% inhibitory concentration (ECIS50) value of 92 µM.{488060} It is also phytotoxic to B. napus leaves.{48807}  

     

    Brand:
    Cayman
    SKU:30210 - 1 mg

    Available on backorder

  • Desvenlafaxine is an active metabolite of the selective norepinephrine and serotonin reuptake inhibitor (SNRI) venlafaxine.{32153} It is formed from venlafaxine by the cytochrome P450 (CYP) isoform CYP2D6.{32155} Desvenlafaxine inhibits the norepinephrine transporter (NET) and serotonin transporter (SERT) with IC50 values of 47.3 and 531.3 nM, respectively, for the human transporters.{32153} It is selective for NET and SERT over 50 receptors, peptides, and ion channels among others. It increases extracellular norepinephrine (NE) in the male rat hypothalamus and increases extracellular serotonin (5-HT) in the same region when used in combination with the 5-HT1A receptor antagonist WAY-100635 (Item No. 14599). Desvenlafaxine (3 mg/kg per day) reduces the time rats spend immobile in the forced swim test in a rat model of cognitive deficits and depression induced by myocardial infarction (MI) when compared with MI-vehicle control animals 16 weeks following MI.{48908} It also improves learning in the passive avoidance step-down test two weeks following MI compared to MI-vehicle control rats and spatial memory in the Morris water maze 16 weeks following MI.  

     

    Brand:
    Cayman
    SKU:29855 - 1 g

    Available on backorder

  • Desvenlafaxine is an active metabolite of the selective norepinephrine and serotonin reuptake inhibitor (SNRI) venlafaxine.{32153} It is formed from venlafaxine by the cytochrome P450 (CYP) isoform CYP2D6.{32155} Desvenlafaxine inhibits the norepinephrine transporter (NET) and serotonin transporter (SERT) with IC50 values of 47.3 and 531.3 nM, respectively, for the human transporters.{32153} It is selective for NET and SERT over 50 receptors, peptides, and ion channels among others. It increases extracellular norepinephrine (NE) in the male rat hypothalamus and increases extracellular serotonin (5-HT) in the same region when used in combination with the 5-HT1A receptor antagonist WAY-100635 (Item No. 14599). Desvenlafaxine (3 mg/kg per day) reduces the time rats spend immobile in the forced swim test in a rat model of cognitive deficits and depression induced by myocardial infarction (MI) when compared with MI-vehicle control animals 16 weeks following MI.{48908} It also improves learning in the passive avoidance step-down test two weeks following MI compared to MI-vehicle control rats and spatial memory in the Morris water maze 16 weeks following MI.  

     

    Brand:
    Cayman
    SKU:29855 - 100 mg

    Available on backorder

  • Desvenlafaxine is an active metabolite of the selective norepinephrine and serotonin reuptake inhibitor (SNRI) venlafaxine.{32153} It is formed from venlafaxine by the cytochrome P450 (CYP) isoform CYP2D6.{32155} Desvenlafaxine inhibits the norepinephrine transporter (NET) and serotonin transporter (SERT) with IC50 values of 47.3 and 531.3 nM, respectively, for the human transporters.{32153} It is selective for NET and SERT over 50 receptors, peptides, and ion channels among others. It increases extracellular norepinephrine (NE) in the male rat hypothalamus and increases extracellular serotonin (5-HT) in the same region when used in combination with the 5-HT1A receptor antagonist WAY-100635 (Item No. 14599). Desvenlafaxine (3 mg/kg per day) reduces the time rats spend immobile in the forced swim test in a rat model of cognitive deficits and depression induced by myocardial infarction (MI) when compared with MI-vehicle control animals 16 weeks following MI.{48908} It also improves learning in the passive avoidance step-down test two weeks following MI compared to MI-vehicle control rats and spatial memory in the Morris water maze 16 weeks following MI.  

     

    Brand:
    Cayman
    SKU:29855 - 25 mg

    Available on backorder

  • Desvenlafaxine is an active metabolite of the selective norepinephrine and serotonin reuptake inhibitor (SNRI) venlafaxine.{32153} It is formed from venlafaxine by the cytochrome P450 (CYP) isoform CYP2D6.{32155} Desvenlafaxine inhibits the norepinephrine transporter (NET) and serotonin transporter (SERT) with IC50 values of 47.3 and 531.3 nM, respectively, for the human transporters.{32153} It is selective for NET and SERT over 50 receptors, peptides, and ion channels among others. It increases extracellular norepinephrine (NE) in the male rat hypothalamus and increases extracellular serotonin (5-HT) in the same region when used in combination with the 5-HT1A receptor antagonist WAY-100635 (Item No. 14599). Desvenlafaxine (3 mg/kg per day) reduces the time rats spend immobile in the forced swim test in a rat model of cognitive deficits and depression induced by myocardial infarction (MI) when compared with MI-vehicle control animals 16 weeks following MI.{48908} It also improves learning in the passive avoidance step-down test two weeks following MI compared to MI-vehicle control rats and spatial memory in the Morris water maze 16 weeks following MI.  

     

    Brand:
    Cayman
    SKU:29855 - 50 mg

    Available on backorder

  • DETA NONOate is a NO donor. It spontaneously dissociates in a pH-dependent, first-order process with a half-life of 20 hours and 56 hours at 37°C and 22-25°C, pH 7.4, respectively, to liberate 2 moles of NO per mole of parent compound.{1190,5437}  

     

    Brand:
    Cayman
    SKU:82120 - 10 mg

    Available on backorder

  • DETA NONOate is a NO donor. It spontaneously dissociates in a pH-dependent, first-order process with a half-life of 20 hours and 56 hours at 37°C and 22-25°C, pH 7.4, respectively, to liberate 2 moles of NO per mole of parent compound.{1190,5437}  

     

    Brand:
    Cayman
    SKU:82120 - 100 mg

    Available on backorder

  • DETA NONOate is a NO donor. It spontaneously dissociates in a pH-dependent, first-order process with a half-life of 20 hours and 56 hours at 37°C and 22-25°C, pH 7.4, respectively, to liberate 2 moles of NO per mole of parent compound.{1190,5437}  

     

    Brand:
    Cayman
    SKU:82120 - 50 mg

    Available on backorder

  • DETA NONOate is a NO donor. It spontaneously dissociates in a pH-dependent, first-order process with a half-life of 20 hours and 56 hours at 37°C and 22-25°C, pH 7.4, respectively, to liberate 2 moles of NO per mole of parent compound.{1190,5437}  

     

    Brand:
    Cayman
    SKU:82120 - 500 mg

    Available on backorder

  • Detomidine is a selective α2-adrenoceptor agonist (Ki = 1.62 nM) that binds to α1-adrenoceptors with much weaker potency (Ki = 415 nM).{25422} It is primarily used as a sedative for horses in large animal veterinary medicine.{28974}  

     

    Brand:
    Cayman
    SKU:-

    Available on backorder

  • Detomidine is a selective α2-adrenoceptor agonist (Ki = 1.62 nM) that binds to α1-adrenoceptors with much weaker potency (Ki = 415 nM).{25422} It is primarily used as a sedative for horses in large animal veterinary medicine.{28974}  

     

    Brand:
    Cayman
    SKU:-

    Available on backorder

  • Detomidine is a selective α2-adrenoceptor agonist (Ki = 1.62 nM) that binds to α1-adrenoceptors with much weaker potency (Ki = 415 nM).{25422} It is primarily used as a sedative for horses in large animal veterinary medicine.{28974}  

     

    Brand:
    Cayman
    SKU:-

    Available on backorder

  • Dexamethasone is a synthetic glucocorticoid that binds the human glucocorticoid receptor with a higher affinity than a natural ligand, cortisol (Kd = 5 nM versus 17 nM, respectively).{20150} Through receptor activation, dexamethasone has both transactivating and transrepressing effects on gene expression, producing, in general, anti-inflammatory results.{20149}  

     

    Brand:
    Cayman
    SKU:11015 - 1 g

    Available on backorder

  • Dexamethasone is a synthetic glucocorticoid that binds the human glucocorticoid receptor with a higher affinity than a natural ligand, cortisol (Kd = 5 nM versus 17 nM, respectively).{20150} Through receptor activation, dexamethasone has both transactivating and transrepressing effects on gene expression, producing, in general, anti-inflammatory results.{20149}  

     

    Brand:
    Cayman
    SKU:11015 - 5 g

    Available on backorder

  • Dexamethasone is a synthetic glucocorticoid that binds the human glucocorticoid receptor with a higher affinity than a natural ligand, cortisol (Kd = 5 nM versus 17 nM, respectively).{20150} Through receptor activation, dexamethasone has both transactivating and transrepressing effects on gene expression, producing, in general, anti-inflammatory results.{20149}  

     

    Brand:
    Cayman
    SKU:11015 - 500 mg

    Available on backorder

  • Dexamethasone acetate is an acetate form of the synthetic glucocorticoid dexamethasone (Item No. 11015). It has a longer duration of action than dexamethasone and its water-soluble form, dexamethasone phosphate (Item No. 20340).{39189} Injectable and topical formulations containing dexamethasone acetate have been used to treat inflammation associated with carpal tunnel syndrome, ocular keratitis, asthma exacerbations, and infertility in men.{39190,39191,39192,39193}  

     

    Brand:
    Cayman
    SKU:22286 -

    Out of stock

  • Dexamethasone acetate is an acetate form of the synthetic glucocorticoid dexamethasone (Item No. 11015). It has a longer duration of action than dexamethasone and its water-soluble form, dexamethasone phosphate (Item No. 20340).{39189} Injectable and topical formulations containing dexamethasone acetate have been used to treat inflammation associated with carpal tunnel syndrome, ocular keratitis, asthma exacerbations, and infertility in men.{39190,39191,39192,39193}  

     

    Brand:
    Cayman
    SKU:22286 -

    Out of stock

  • Dexamethasone acetate is an acetate form of the synthetic glucocorticoid dexamethasone (Item No. 11015). It has a longer duration of action than dexamethasone and its water-soluble form, dexamethasone phosphate (Item No. 20340).{39189} Injectable and topical formulations containing dexamethasone acetate have been used to treat inflammation associated with carpal tunnel syndrome, ocular keratitis, asthma exacerbations, and infertility in men.{39190,39191,39192,39193}  

     

    Brand:
    Cayman
    SKU:22286 -

    Out of stock

  • Dexamethasone acetate is an acetate form of the synthetic glucocorticoid dexamethasone (Item No. 11015). It has a longer duration of action than dexamethasone and its water-soluble form, dexamethasone phosphate (Item No. 20340).{39189} Injectable and topical formulations containing dexamethasone acetate have been used to treat inflammation associated with carpal tunnel syndrome, ocular keratitis, asthma exacerbations, and infertility in men.{39190,39191,39192,39193}  

     

    Brand:
    Cayman
    SKU:22286 -

    Out of stock

  • Dexamethasone phosphate is a water-soluble form of the synthetic glucocorticoid dexamethasone (Item No. 11015). Dexamethasone binds the human glucocorticoid receptor with a higher affinity than a natural ligand, cortisol (Kd = 5 nM vs. 17 nM, respectively).{20150} Through receptor activation, dexamethasone has both transactivating and transrepressing effects on gene expression, producing, in general, anti-inflammatory results in clinical trials.{20149}  

     

    Brand:
    Cayman
    SKU:20340 -

    Available on backorder

  • Dexamethasone phosphate is a water-soluble form of the synthetic glucocorticoid dexamethasone (Item No. 11015). Dexamethasone binds the human glucocorticoid receptor with a higher affinity than a natural ligand, cortisol (Kd = 5 nM vs. 17 nM, respectively).{20150} Through receptor activation, dexamethasone has both transactivating and transrepressing effects on gene expression, producing, in general, anti-inflammatory results in clinical trials.{20149}  

     

    Brand:
    Cayman
    SKU:20340 -

    Available on backorder

  • Dexamethasone phosphate is a water-soluble form of the synthetic glucocorticoid dexamethasone (Item No. 11015). Dexamethasone binds the human glucocorticoid receptor with a higher affinity than a natural ligand, cortisol (Kd = 5 nM vs. 17 nM, respectively).{20150} Through receptor activation, dexamethasone has both transactivating and transrepressing effects on gene expression, producing, in general, anti-inflammatory results in clinical trials.{20149}  

     

    Brand:
    Cayman
    SKU:20340 -

    Available on backorder

  • Dexamethasone phosphate is a water-soluble form of the synthetic glucocorticoid dexamethasone (Item No. 11015). Dexamethasone binds the human glucocorticoid receptor with a higher affinity than a natural ligand, cortisol (Kd = 5 nM vs. 17 nM, respectively).{20150} Through receptor activation, dexamethasone has both transactivating and transrepressing effects on gene expression, producing, in general, anti-inflammatory results in clinical trials.{20149}  

     

    Brand:
    Cayman
    SKU:20340 -

    Available on backorder

  • Dexchlorpheniramine is a histamine H1 receptor antagonist with a pA2 value of 9.36 in guinea pig ileal tissue in vitro.{41542} It inhibits the proliferation of previously sensitized, allergen-challenged peripheral blood mononuclear cells by 92% at a concentration of 4.8 µM.{41541} Dexchlorpheniramine reduces noradrenaline uptake in the rat vas deferens ex vivo in response to tyramine stimulation when used at a concentration of 10 µM.{41539} In vivo, dexchlorpheniramine increases the pain threshold of mice exposed to thermal and chemical stimulation tests when administered intraperitoneally at a dose of 30 mg/kg.{41540} Formulations containing dexchlorpheniramine have been used for the treatment of allergic reactions.  

     

    Brand:
    Cayman
    SKU:24027 - 1 g

    Available on backorder

  • Dexchlorpheniramine is a histamine H1 receptor antagonist with a pA2 value of 9.36 in guinea pig ileal tissue in vitro.{41542} It inhibits the proliferation of previously sensitized, allergen-challenged peripheral blood mononuclear cells by 92% at a concentration of 4.8 µM.{41541} Dexchlorpheniramine reduces noradrenaline uptake in the rat vas deferens ex vivo in response to tyramine stimulation when used at a concentration of 10 µM.{41539} In vivo, dexchlorpheniramine increases the pain threshold of mice exposed to thermal and chemical stimulation tests when administered intraperitoneally at a dose of 30 mg/kg.{41540} Formulations containing dexchlorpheniramine have been used for the treatment of allergic reactions.  

     

    Brand:
    Cayman
    SKU:24027 - 500 mg

    Available on backorder

  • Dexmedetomidine is the (S)-enantiomer of medetomidine, an imidazole compound that binds to α2-adrenoceptors (Ki = 1.08 nM) with high affinity and selectivity compared to that of α1-adrenoceptors (Ki = 1.8 μM).{25422} Dexmedetomidine produces analgesic, sedative, and anxiolytic effects through both presynaptic activation of α2-adrenoceptors, which inhibits norepinephrine release, and postsynaptic activation of α2-adrenoceptors, which inhibits sympathetic activity and decreases blood pressure and heart rate.{25423,25424}  

     

    Brand:
    Cayman
    SKU:-
  • Dexmedetomidine is the (S)-enantiomer of medetomidine, an imidazole compound that binds to α2-adrenoceptors (Ki = 1.08 nM) with high affinity and selectivity compared to that of α1-adrenoceptors (Ki = 1.8 μM).{25422} Dexmedetomidine produces analgesic, sedative, and anxiolytic effects through both presynaptic activation of α2-adrenoceptors, which inhibits norepinephrine release, and postsynaptic activation of α2-adrenoceptors, which inhibits sympathetic activity and decreases blood pressure and heart rate.{25423,25424}  

     

    Brand:
    Cayman
    SKU:-
  • Dexmedetomidine is the (S)-enantiomer of medetomidine, an imidazole compound that binds to α2-adrenoceptors (Ki = 1.08 nM) with high affinity and selectivity compared to that of α1-adrenoceptors (Ki = 1.8 μM).{25422} Dexmedetomidine produces analgesic, sedative, and anxiolytic effects through both presynaptic activation of α2-adrenoceptors, which inhibits norepinephrine release, and postsynaptic activation of α2-adrenoceptors, which inhibits sympathetic activity and decreases blood pressure and heart rate.{25423,25424}  

     

    Brand:
    Cayman
    SKU:-
  • Dexmedetomidine is the (S)-enantiomer of medetomidine, an imidazole compound that binds to α2-adrenoceptors (Ki = 1.08 nM) with high affinity and selectivity compared to that of α1-adrenoceptors (Ki = 1.8 μM).{25422} Dexmedetomidine produces analgesic, sedative, and anxiolytic effects through both presynaptic activation of α2-adrenoceptors, which inhibits norepinephrine release, and postsynaptic activation of α2-adrenoceptors, which inhibits sympathetic activity and decreases blood pressure and heart rate.{25423,25424}  

     

    Brand:
    Cayman
    SKU:-
  • Dexrazoxane is an intracellular iron chelator and an inhibitor of topoisomerase IIα.{23203} Through these activities, dexazoxane is highly protective in reducing anthracycline-induced cardiotoxicity and extravasation injury.{23202} Dexrazoxane has also been shown to act as an antioxidant that scavenges hydroxyl (IC50 = 2.1 mM), superoxide (IC50 = 0.4 mM), lipid (IC50 = 4.4 mM), 2,2-diphenyl-1-picrylhydrazyl (IC50 = 3.5 μM), and 2,2’-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) (IC50 = 3.8 mM) free radicals.{23201}  

     

    Brand:
    Cayman
    SKU:-
  • Dexrazoxane is an intracellular iron chelator and an inhibitor of topoisomerase IIα.{23203} Through these activities, dexazoxane is highly protective in reducing anthracycline-induced cardiotoxicity and extravasation injury.{23202} Dexrazoxane has also been shown to act as an antioxidant that scavenges hydroxyl (IC50 = 2.1 mM), superoxide (IC50 = 0.4 mM), lipid (IC50 = 4.4 mM), 2,2-diphenyl-1-picrylhydrazyl (IC50 = 3.5 μM), and 2,2’-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) (IC50 = 3.8 mM) free radicals.{23201}  

     

    Brand:
    Cayman
    SKU:-
  • Dexrazoxane is an intracellular iron chelator and an inhibitor of topoisomerase IIα.{23203} Through these activities, dexazoxane is highly protective in reducing anthracycline-induced cardiotoxicity and extravasation injury.{23202} Dexrazoxane has also been shown to act as an antioxidant that scavenges hydroxyl (IC50 = 2.1 mM), superoxide (IC50 = 0.4 mM), lipid (IC50 = 4.4 mM), 2,2-diphenyl-1-picrylhydrazyl (IC50 = 3.5 μM), and 2,2’-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) (IC50 = 3.8 mM) free radicals.{23201}  

     

    Brand:
    Cayman
    SKU:-
  • Dexrazoxane is an intracellular iron chelator and an inhibitor of topoisomerase IIα.{23203} Through these activities, dexazoxane is highly protective in reducing anthracycline-induced cardiotoxicity and extravasation injury.{23202} Dexrazoxane has also been shown to act as an antioxidant that scavenges hydroxyl (IC50 = 2.1 mM), superoxide (IC50 = 0.4 mM), lipid (IC50 = 4.4 mM), 2,2-diphenyl-1-picrylhydrazyl (IC50 = 3.5 μM), and 2,2’-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) (IC50 = 3.8 mM) free radicals.{23201}  

     

    Brand:
    Cayman
    SKU:-
  • Dextran sulfate is a sulfated polysaccharide of variable molecular weight ranging from 5 to 1,400 kDa.{38311} Oral administration of dextran sulfate induces colonic inflammation in a mouse model of inflammatory bowel disease (IBD). Acute, chronic, and relapsing models of IBD can be induced by varying the concentration and administration frequency of dextran sulfate. Dextran sulfate has also been used in molecular biology applications including precipitation of lipoproteins, acceleration of DNA probe hybridization to nucleic acids, and ribosomal isolations.{38312,38313,38314}  

     

    Brand:
    Cayman
    SKU:23250 - 10 g

    Available on backorder

  • Dextran sulfate is a sulfated polysaccharide of variable molecular weight ranging from 5 to 1,400 kDa.{38311} Oral administration of dextran sulfate induces colonic inflammation in a mouse model of inflammatory bowel disease (IBD). Acute, chronic, and relapsing models of IBD can be induced by varying the concentration and administration frequency of dextran sulfate. Dextran sulfate has also been used in molecular biology applications including precipitation of lipoproteins, acceleration of DNA probe hybridization to nucleic acids, and ribosomal isolations.{38312,38313,38314}  

     

    Brand:
    Cayman
    SKU:23250 - 100 g

    Available on backorder

  • Dextran sulfate is a sulfated polysaccharide of variable molecular weight ranging from 5 to 1,400 kDa.{38311} Oral administration of dextran sulfate induces colonic inflammation in a mouse model of inflammatory bowel disease (IBD). Acute, chronic, and relapsing models of IBD can be induced by varying the concentration and administration frequency of dextran sulfate. Dextran sulfate has also been used in molecular biology applications including precipitation of lipoproteins, acceleration of DNA probe hybridization to nucleic acids, and ribosomal isolations.{38312,38313,38314}  

     

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    Cayman
    SKU:23250 - 25 g

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  • Dextran sulfate is a sulfated polysaccharide of variable molecular weight ranging from 5 to 1,400 kDa.{38311} Oral administration of dextran sulfate induces colonic inflammation in a mouse model of inflammatory bowel disease (IBD). Acute, chronic, and relapsing models of IBD can be induced by varying the concentration and administration frequency of dextran sulfate. Dextran sulfate has also been used in molecular biology applications including precipitation of lipoproteins, acceleration of DNA probe hybridization to nucleic acids, and ribosomal isolations.{38312,38313,38314}  

     

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    Cayman
    SKU:23250 - 50 g

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  • Dextromethorphan (DXM) is a dextratrorotatory morphinan with structural similarity to levorphanol, codeine, and morphine. Because of its strong antitussive effects, dextromethorphan is widely used as a cough suppressant.{21979} However, it does not provoke opioid activity as is characteristic of several other morphine derivatives. DXM binds to and inhibits NMDA (IC50 = 0.55 μM) and nicotinic receptors (IC50s = 0.7-3.9 μM) and blocks receptor-gated and voltage-gated calcium channels (IC50 = 60 μM) and voltage-gated sodium channels (IC50 = 78 μM).{21979,21978,21981} DXM has been used in multimodal analgesic therapies for acute and neuropathic pain.{21979,21980}  

     

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    Cayman
    SKU:-
  • Dextromethorphan (DXM) is a dextratrorotatory morphinan with structural similarity to levorphanol, codeine, and morphine. Because of its strong antitussive effects, dextromethorphan is widely used as a cough suppressant.{21979} However, it does not provoke opioid activity as is characteristic of several other morphine derivatives. DXM binds to and inhibits NMDA (IC50 = 0.55 μM) and nicotinic receptors (IC50s = 0.7-3.9 μM) and blocks receptor-gated and voltage-gated calcium channels (IC50 = 60 μM) and voltage-gated sodium channels (IC50 = 78 μM).{21979,21978,21981} DXM has been used in multimodal analgesic therapies for acute and neuropathic pain.{21979,21980}  

     

    Brand:
    Cayman
    SKU:-
  • Dextromethorphan (DXM) is a dextratrorotatory morphinan with structural similarity to levorphanol, codeine, and morphine. Because of its strong antitussive effects, dextromethorphan is widely used as a cough suppressant.{21979} However, it does not provoke opioid activity as is characteristic of several other morphine derivatives. DXM binds to and inhibits NMDA (IC50 = 0.55 μM) and nicotinic receptors (IC50s = 0.7-3.9 μM) and blocks receptor-gated and voltage-gated calcium channels (IC50 = 60 μM) and voltage-gated sodium channels (IC50 = 78 μM).{21979,21978,21981} DXM has been used in multimodal analgesic therapies for acute and neuropathic pain.{21979,21980}  

     

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    Cayman
    SKU:-
  • DFPM is a modulator of plant signaling first demonstrated to down-regulate ABA-dependent gene expression (IC50 = 3 µM) and stomatal closure.{32818} It stimulates the expression of several plant defense-related genes and blocks signaling triggered by phytoalexin deficient 4 (PAD4).{32818} DFPM also induces root growth arrest in certain accessions of A. thaliana through the expression of a novel protein that interacts with PAD4.{32819}  

     

    Brand:
    Cayman
    SKU:19830 -

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  • DFPM is a modulator of plant signaling first demonstrated to down-regulate ABA-dependent gene expression (IC50 = 3 µM) and stomatal closure.{32818} It stimulates the expression of several plant defense-related genes and blocks signaling triggered by phytoalexin deficient 4 (PAD4).{32818} DFPM also induces root growth arrest in certain accessions of A. thaliana through the expression of a novel protein that interacts with PAD4.{32819}  

     

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    Cayman
    SKU:19830 -

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  • DFPM is a modulator of plant signaling first demonstrated to down-regulate ABA-dependent gene expression (IC50 = 3 µM) and stomatal closure.{32818} It stimulates the expression of several plant defense-related genes and blocks signaling triggered by phytoalexin deficient 4 (PAD4).{32818} DFPM also induces root growth arrest in certain accessions of A. thaliana through the expression of a novel protein that interacts with PAD4.{32819}  

     

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    Cayman
    SKU:19830 -

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  • DG-051 is a potent, orally bioavailable leukotriene A4 hydrolase (LTA4H) inhibitor (Kd = 25 nM; IC50 = 47 nM), the enzyme that catalyzes the rate-determining step in the synthesis of LTB4 (Item No. 20110).{34688} However, it also inhibits the aminopeptidase activity of LTA4H with IC50 values of 72 and 150 nM when tested using the substrates L-alanine p-nitroanaline and prolyl-glycyl-proline peptide (PGP; Item No. 11188), respectively, potentially leading to PGP accumulation in vivo.{34688,34689} DG-051 does not show any inhibitory activity against a panel of more than 50 additional aminopeptidases, ion channels, or HERG.{34688}  

     

    Brand:
    Cayman
    SKU:21688 -

    Out of stock

  • DG-051 is a potent, orally bioavailable leukotriene A4 hydrolase (LTA4H) inhibitor (Kd = 25 nM; IC50 = 47 nM), the enzyme that catalyzes the rate-determining step in the synthesis of LTB4 (Item No. 20110).{34688} However, it also inhibits the aminopeptidase activity of LTA4H with IC50 values of 72 and 150 nM when tested using the substrates L-alanine p-nitroanaline and prolyl-glycyl-proline peptide (PGP; Item No. 11188), respectively, potentially leading to PGP accumulation in vivo.{34688,34689} DG-051 does not show any inhibitory activity against a panel of more than 50 additional aminopeptidases, ion channels, or HERG.{34688}  

     

    Brand:
    Cayman
    SKU:21688 -

    Out of stock

  • DG-051 is a potent, orally bioavailable leukotriene A4 hydrolase (LTA4H) inhibitor (Kd = 25 nM; IC50 = 47 nM), the enzyme that catalyzes the rate-determining step in the synthesis of LTB4 (Item No. 20110).{34688} However, it also inhibits the aminopeptidase activity of LTA4H with IC50 values of 72 and 150 nM when tested using the substrates L-alanine p-nitroanaline and prolyl-glycyl-proline peptide (PGP; Item No. 11188), respectively, potentially leading to PGP accumulation in vivo.{34688,34689} DG-051 does not show any inhibitory activity against a panel of more than 50 additional aminopeptidases, ion channels, or HERG.{34688}  

     

    Brand:
    Cayman
    SKU:21688 -

    Out of stock

  • DG-051 is a potent, orally bioavailable leukotriene A4 hydrolase (LTA4H) inhibitor (Kd = 25 nM; IC50 = 47 nM), the enzyme that catalyzes the rate-determining step in the synthesis of LTB4 (Item No. 20110).{34688} However, it also inhibits the aminopeptidase activity of LTA4H with IC50 values of 72 and 150 nM when tested using the substrates L-alanine p-nitroanaline and prolyl-glycyl-proline peptide (PGP; Item No. 11188), respectively, potentially leading to PGP accumulation in vivo.{34688,34689} DG-051 does not show any inhibitory activity against a panel of more than 50 additional aminopeptidases, ion channels, or HERG.{34688}  

     

    Brand:
    Cayman
    SKU:21688 -

    Out of stock

  • DG-172 is an orally available inverse agonist of PPARβ/δ (IC50 = 27 nM), down-regulating transcription of ANGPTL4 in mouse myoblasts (IC50 = 9.5 nM).{31239} It alters the differentiation of bone marrow cells, augmenting GM-CSF-induced development into subsets of mature and immature dendritic cells.{31238} Inverse agonists of PPARβ/δ, including DG-172, inhibit cancer cell invasion through suppression of ANGPTL4 expression.{31237}  

     

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    Cayman
    SKU:-

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  • DG-172 is an orally available inverse agonist of PPARβ/δ (IC50 = 27 nM), down-regulating transcription of ANGPTL4 in mouse myoblasts (IC50 = 9.5 nM).{31239} It alters the differentiation of bone marrow cells, augmenting GM-CSF-induced development into subsets of mature and immature dendritic cells.{31238} Inverse agonists of PPARβ/δ, including DG-172, inhibit cancer cell invasion through suppression of ANGPTL4 expression.{31237}  

     

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    Cayman
    SKU:-

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  • DG-172 is an orally available inverse agonist of PPARβ/δ (IC50 = 27 nM), down-regulating transcription of ANGPTL4 in mouse myoblasts (IC50 = 9.5 nM).{31239} It alters the differentiation of bone marrow cells, augmenting GM-CSF-induced development into subsets of mature and immature dendritic cells.{31238} Inverse agonists of PPARβ/δ, including DG-172, inhibit cancer cell invasion through suppression of ANGPTL4 expression.{31237}  

     

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    Cayman
    SKU:-

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  • DG-172 is an orally available inverse agonist of PPARβ/δ (IC50 = 27 nM), down-regulating transcription of ANGPTL4 in mouse myoblasts (IC50 = 9.5 nM).{31239} It alters the differentiation of bone marrow cells, augmenting GM-CSF-induced development into subsets of mature and immature dendritic cells.{31238} Inverse agonists of PPARβ/δ, including DG-172, inhibit cancer cell invasion through suppression of ANGPTL4 expression.{31237}  

     

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    Cayman
    SKU:-

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  • DH 97 is an antagonist of melatonin receptor 2 (MT2; Kis = 252 and 1,100 for human MT2 and MT1 receptors, respectively).{53155}  

     

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    Cayman
    SKU:29522 - 1 mg

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  • DH 97 is an antagonist of melatonin receptor 2 (MT2; Kis = 252 and 1,100 for human MT2 and MT1 receptors, respectively).{53155}  

     

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    Cayman
    SKU:29522 - 10 mg

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  • DH 97 is an antagonist of melatonin receptor 2 (MT2; Kis = 252 and 1,100 for human MT2 and MT1 receptors, respectively).{53155}  

     

    Brand:
    Cayman
    SKU:29522 - 25 mg

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  • DH 97 is an antagonist of melatonin receptor 2 (MT2; Kis = 252 and 1,100 for human MT2 and MT1 receptors, respectively).{53155}  

     

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    Cayman
    SKU:29522 - 5 mg

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  • Lipid peroxidation is a well-established mechanism of cellular injury in both plants and animals and is used as an indicator of oxidative stress in cells and tissues. Measurement of 4-hydroxy-2-nonenal (HNE), an aldehyde formed during the lipid peroxidation process, is one of several accepted biomarkers for lipid peroxidation. 1,4-Dihydroxynonane mercapturic acid (DHN-MA) is the major urinary metabolite of HNE present at physiological levels in rat and human urine. It can be measured without extraction and offers an alternative lipid peroxidation biomarker aside from 8-isoprostane or TBARS. This DHN-MA EIA Kit is a competitive assay that can be used for quantification of DHN-MA in urine samples. The EIA typically displays an IC50 (50% B/B0) of approximately 75 pg/ml and a detection limit (80% B/B0) of approximately 10 pg/ml. [Bertin Catalog No. A05185]  

     

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    Cayman
    SKU:501140 - 96 wells

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  • Di-4-ANEPPS is a potentiometric fluorescent dye that can be used to measure membrane potential.{49012} It displays absorption/emission maxima of 495/705 nm, respectively.{22804} The relative fluorescence changes proportionally to membrane potential at a rate of approximately 10% per 100 mV.{49012} Di-4-ANEPPS has been used to measure membrane potential in a variety of tissue and cell types as well as artificial membranes.{49012,22804}  

     

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    Cayman
    SKU:26801 - 1 mg

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  • Di-4-ANEPPS is a potentiometric fluorescent dye that can be used to measure membrane potential.{49012} It displays absorption/emission maxima of 495/705 nm, respectively.{22804} The relative fluorescence changes proportionally to membrane potential at a rate of approximately 10% per 100 mV.{49012} Di-4-ANEPPS has been used to measure membrane potential in a variety of tissue and cell types as well as artificial membranes.{49012,22804}  

     

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    Cayman
    SKU:26801 - 5 mg

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  • Di-8-ANEPPS is a potentiometric fluorescent dye that can be used to noninvasively measure transmembrane voltage.{31479} It is not fluorescent in water, but when bound to the lipid bilayer, becomes strongly fluorescent (ex/em max = ~467/631 nm). The fluorescence intensity of di-8-ANEPPS varies proportionally to changes in transmembrane voltage. This dye is most suitable for measuring larger changes in membrane voltage, such as the onset of induced membrane voltage in nonexcitable cells exposed to external electric fields or action potentials in excitable cells.{31479} Since di-8-ANEPPS stains the membrane, it can also be used simply as a cell membrane marker.  

     

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    Cayman
    SKU:-

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  • Di-8-ANEPPS is a potentiometric fluorescent dye that can be used to noninvasively measure transmembrane voltage.{31479} It is not fluorescent in water, but when bound to the lipid bilayer, becomes strongly fluorescent (ex/em max = ~467/631 nm). The fluorescence intensity of di-8-ANEPPS varies proportionally to changes in transmembrane voltage. This dye is most suitable for measuring larger changes in membrane voltage, such as the onset of induced membrane voltage in nonexcitable cells exposed to external electric fields or action potentials in excitable cells.{31479} Since di-8-ANEPPS stains the membrane, it can also be used simply as a cell membrane marker.  

     

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    Cayman
    SKU:-

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  • Di-8-ANEPPS is a potentiometric fluorescent dye that can be used to noninvasively measure transmembrane voltage.{31479} It is not fluorescent in water, but when bound to the lipid bilayer, becomes strongly fluorescent (ex/em max = ~467/631 nm). The fluorescence intensity of di-8-ANEPPS varies proportionally to changes in transmembrane voltage. This dye is most suitable for measuring larger changes in membrane voltage, such as the onset of induced membrane voltage in nonexcitable cells exposed to external electric fields or action potentials in excitable cells.{31479} Since di-8-ANEPPS stains the membrane, it can also be used simply as a cell membrane marker.  

     

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    Cayman
    SKU:-

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  • Di-α-linolenin is a diacylglycerol that contains the polyunsaturated 18-carbon fatty acid α-linolenic acid (Item Nos. 90210 | 21910) at two positions.  

     

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    Cayman
    SKU:27013 - 10 mg

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  • Di-α-linolenin is a diacylglycerol that contains the polyunsaturated 18-carbon fatty acid α-linolenic acid (Item Nos. 90210 | 21910) at two positions.  

     

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    Cayman
    SKU:27013 - 25 mg

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  • Di-α-linolenin is a diacylglycerol that contains the polyunsaturated 18-carbon fatty acid α-linolenic acid (Item Nos. 90210 | 21910) at two positions.  

     

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    Cayman
    SKU:27013 - 5 mg

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  • Di-γ-linolenin is a diacylglycerol that contains the ω-6 fatty acid γ-linolenic acid (Item No. 90220) at two positions.  

     

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    Cayman
    SKU:26973 - 1 mg

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  • Di-γ-linolenin is a diacylglycerol that contains the ω-6 fatty acid γ-linolenic acid (Item No. 90220) at two positions.  

     

    Brand:
    Cayman
    SKU:26973 - 10 mg

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  • Di-γ-linolenin is a diacylglycerol that contains the ω-6 fatty acid γ-linolenic acid (Item No. 90220) at two positions.  

     

    Brand:
    Cayman
    SKU:26973 - 25 mg

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  • Di-γ-linolenin is a diacylglycerol that contains the ω-6 fatty acid γ-linolenic acid (Item No. 90220) at two positions.  

     

    Brand:
    Cayman
    SKU:26973 - 5 mg

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