Cayman
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Dehydroergosterol is a naturally occurring, fluorescent analog of cholesterol (ex/em = 324/375 nm) that mimics the properties of cholesterol in cell membranes.{32485} It is readily bound by cholesterol-binding proteins and has been used for real-time probing of the sterol environment and to elucidate intracellular sterol trafficking in living organisms.{32485}
Brand:CaymanSKU:19709 -Available on backorder
Dehydroergosterol is a naturally occurring, fluorescent analog of cholesterol (ex/em = 324/375 nm) that mimics the properties of cholesterol in cell membranes.{32485} It is readily bound by cholesterol-binding proteins and has been used for real-time probing of the sterol environment and to elucidate intracellular sterol trafficking in living organisms.{32485}
Brand:CaymanSKU:19709 -Available on backorder
Dehydroergosterol is a naturally occurring, fluorescent analog of cholesterol (ex/em = 324/375 nm) that mimics the properties of cholesterol in cell membranes.{32485} It is readily bound by cholesterol-binding proteins and has been used for real-time probing of the sterol environment and to elucidate intracellular sterol trafficking in living organisms.{32485}
Brand:CaymanSKU:19709 -Available on backorder
Dehydroergosterol is a naturally occurring, fluorescent analog of cholesterol (ex/em = 324/375 nm) that mimics the properties of cholesterol in cell membranes.{32485} It is readily bound by cholesterol-binding proteins and has been used for real-time probing of the sterol environment and to elucidate intracellular sterol trafficking in living organisms.{32485}
Brand:CaymanSKU:19709 -Available on backorder
Dehydroevodiamine is an alkaloid that has been isolated from E. rutaecarpa and has anti-inflammatory, antiarrhythmic, hypotensive, and anti-amnesic biological activities.{37668,37669,37670,37671} It inhibits LPS-induced secretion of prostaglandin E2 (PGE2; Item No. 14010) in RAW 264.7 mouse macrophages when used at a concentration of 30 μM.{37668} Dehydroevodiamine (0.1-0.3 μM) reduces the upstroke velocity, action potential amplitude, and contractile force of electrically-stimulated primary human atrial trabeculae.{37669} In vivo, dehydroevodiamine (10 mg/kg) decreases mean arterial blood pressure (MAP) by approximately 30% in rats.{37670} Dehydroevodiamine (1.5 mg/kg) also inhibits amnesia induced by amyloid-β (25-35) (Item No. 24155) and increases latency to step-through in a passive avoidance test in mice.{37671}
Brand:CaymanSKU:25101 - 100 mgAvailable on backorder
Dehydroevodiamine is an alkaloid that has been isolated from E. rutaecarpa and has anti-inflammatory, antiarrhythmic, hypotensive, and anti-amnesic biological activities.{37668,37669,37670,37671} It inhibits LPS-induced secretion of prostaglandin E2 (PGE2; Item No. 14010) in RAW 264.7 mouse macrophages when used at a concentration of 30 μM.{37668} Dehydroevodiamine (0.1-0.3 μM) reduces the upstroke velocity, action potential amplitude, and contractile force of electrically-stimulated primary human atrial trabeculae.{37669} In vivo, dehydroevodiamine (10 mg/kg) decreases mean arterial blood pressure (MAP) by approximately 30% in rats.{37670} Dehydroevodiamine (1.5 mg/kg) also inhibits amnesia induced by amyloid-β (25-35) (Item No. 24155) and increases latency to step-through in a passive avoidance test in mice.{37671}
Brand:CaymanSKU:25101 - 25 mgAvailable on backorder
Dehydroevodiamine is an alkaloid that has been isolated from E. rutaecarpa and has anti-inflammatory, antiarrhythmic, hypotensive, and anti-amnesic biological activities.{37668,37669,37670,37671} It inhibits LPS-induced secretion of prostaglandin E2 (PGE2; Item No. 14010) in RAW 264.7 mouse macrophages when used at a concentration of 30 μM.{37668} Dehydroevodiamine (0.1-0.3 μM) reduces the upstroke velocity, action potential amplitude, and contractile force of electrically-stimulated primary human atrial trabeculae.{37669} In vivo, dehydroevodiamine (10 mg/kg) decreases mean arterial blood pressure (MAP) by approximately 30% in rats.{37670} Dehydroevodiamine (1.5 mg/kg) also inhibits amnesia induced by amyloid-β (25-35) (Item No. 24155) and increases latency to step-through in a passive avoidance test in mice.{37671}
Brand:CaymanSKU:25101 - 250 mgAvailable on backorder
Dehydroevodiamine is an alkaloid that has been isolated from E. rutaecarpa and has anti-inflammatory, antiarrhythmic, hypotensive, and anti-amnesic biological activities.{37668,37669,37670,37671} It inhibits LPS-induced secretion of prostaglandin E2 (PGE2; Item No. 14010) in RAW 264.7 mouse macrophages when used at a concentration of 30 μM.{37668} Dehydroevodiamine (0.1-0.3 μM) reduces the upstroke velocity, action potential amplitude, and contractile force of electrically-stimulated primary human atrial trabeculae.{37669} In vivo, dehydroevodiamine (10 mg/kg) decreases mean arterial blood pressure (MAP) by approximately 30% in rats.{37670} Dehydroevodiamine (1.5 mg/kg) also inhibits amnesia induced by amyloid-β (25-35) (Item No. 24155) and increases latency to step-through in a passive avoidance test in mice.{37671}
Brand:CaymanSKU:25101 - 50 mgAvailable on backorder
Dehydrolithocholic acid is a major metabolite of lithocholic acid (LCA; Item No. 20253).{48226} It is formed from LCA by the cytochrome P450 (CYP) isoform CYP3A4. Dehydrolithocholic acid is an agonist of G protein-coupled bile acid activated receptor 1 (GP-BAR1/TGR5; EC50 = 0.27 μM), vitamin D receptor (VDR; EC50 = 3 μM), and farnesoid X receptor (FXR) in cell-based reporter assays.{53582,10150} It also binds to the human pregnane X receptor (PXR; IC50 = 15 μM) and activates mouse and human PXRs in cell-based reporter assays when used at a concentration of 100 μM.{32396} Dehydrolithocholic acid binds to retinoic acid receptor-related orphan receptor γt (RORγt; Kd = 1.13 μM for the recombinant human ligand-binding domain) and decreases its activity in a cell-based reporter assay when used at a concentration of 10 μM.{53583} It inhibits the differentiation of T helper cells that express IL-17a (TH17 cells) when used at a concentration of 20 μM.
Brand:CaymanSKU:29544 - 10 mgAvailable on backorder
Dehydrolithocholic acid is a major metabolite of lithocholic acid (LCA; Item No. 20253).{48226} It is formed from LCA by the cytochrome P450 (CYP) isoform CYP3A4. Dehydrolithocholic acid is an agonist of G protein-coupled bile acid activated receptor 1 (GP-BAR1/TGR5; EC50 = 0.27 μM), vitamin D receptor (VDR; EC50 = 3 μM), and farnesoid X receptor (FXR) in cell-based reporter assays.{53582,10150} It also binds to the human pregnane X receptor (PXR; IC50 = 15 μM) and activates mouse and human PXRs in cell-based reporter assays when used at a concentration of 100 μM.{32396} Dehydrolithocholic acid binds to retinoic acid receptor-related orphan receptor γt (RORγt; Kd = 1.13 μM for the recombinant human ligand-binding domain) and decreases its activity in a cell-based reporter assay when used at a concentration of 10 μM.{53583} It inhibits the differentiation of T helper cells that express IL-17a (TH17 cells) when used at a concentration of 20 μM.
Brand:CaymanSKU:29544 - 100 mgAvailable on backorder
Dehydrolithocholic acid is a major metabolite of lithocholic acid (LCA; Item No. 20253).{48226} It is formed from LCA by the cytochrome P450 (CYP) isoform CYP3A4. Dehydrolithocholic acid is an agonist of G protein-coupled bile acid activated receptor 1 (GP-BAR1/TGR5; EC50 = 0.27 μM), vitamin D receptor (VDR; EC50 = 3 μM), and farnesoid X receptor (FXR) in cell-based reporter assays.{53582,10150} It also binds to the human pregnane X receptor (PXR; IC50 = 15 μM) and activates mouse and human PXRs in cell-based reporter assays when used at a concentration of 100 μM.{32396} Dehydrolithocholic acid binds to retinoic acid receptor-related orphan receptor γt (RORγt; Kd = 1.13 μM for the recombinant human ligand-binding domain) and decreases its activity in a cell-based reporter assay when used at a concentration of 10 μM.{53583} It inhibits the differentiation of T helper cells that express IL-17a (TH17 cells) when used at a concentration of 20 μM.
Brand:CaymanSKU:29544 - 250 mgAvailable on backorder
Dehydrolithocholic acid is a major metabolite of lithocholic acid (LCA; Item No. 20253).{48226} It is formed from LCA by the cytochrome P450 (CYP) isoform CYP3A4. Dehydrolithocholic acid is an agonist of G protein-coupled bile acid activated receptor 1 (GP-BAR1/TGR5; EC50 = 0.27 μM), vitamin D receptor (VDR; EC50 = 3 μM), and farnesoid X receptor (FXR) in cell-based reporter assays.{53582,10150} It also binds to the human pregnane X receptor (PXR; IC50 = 15 μM) and activates mouse and human PXRs in cell-based reporter assays when used at a concentration of 100 μM.{32396} Dehydrolithocholic acid binds to retinoic acid receptor-related orphan receptor γt (RORγt; Kd = 1.13 μM for the recombinant human ligand-binding domain) and decreases its activity in a cell-based reporter assay when used at a concentration of 10 μM.{53583} It inhibits the differentiation of T helper cells that express IL-17a (TH17 cells) when used at a concentration of 20 μM.
Brand:CaymanSKU:29544 - 50 mgAvailable on backorder
DEL-22379 is an inhibitor of ERK dimerization that disrupts EGF-induced co-immunoprecipitation of ERK tagged with hemagglutinin (HA) or FLAG epitopes with an IC50 value of approximately 0.5 μM without affecting ERK phosphorylation or kinase activity (IC50s = >10 μM).{37660} It inhibits cell growth in a panel of melanoma and colorectal cancer cell lines (IC50s = 150-400 nM). DEL-22379 (15 mg/kg, i.p.) inhibits ERK dimerization in liver extract and tumor tissue and inhibits tumor progression in an A375 mouse xenograft model. It also reduces tumor growth in a BRAF mutant colorectal cancer patient-derived xenograft (PDX) mouse model.
Brand:CaymanSKU:22433 -Out of stock
DEL-22379 is an inhibitor of ERK dimerization that disrupts EGF-induced co-immunoprecipitation of ERK tagged with hemagglutinin (HA) or FLAG epitopes with an IC50 value of approximately 0.5 μM without affecting ERK phosphorylation or kinase activity (IC50s = >10 μM).{37660} It inhibits cell growth in a panel of melanoma and colorectal cancer cell lines (IC50s = 150-400 nM). DEL-22379 (15 mg/kg, i.p.) inhibits ERK dimerization in liver extract and tumor tissue and inhibits tumor progression in an A375 mouse xenograft model. It also reduces tumor growth in a BRAF mutant colorectal cancer patient-derived xenograft (PDX) mouse model.
Brand:CaymanSKU:22433 -Out of stock
DEL-22379 is an inhibitor of ERK dimerization that disrupts EGF-induced co-immunoprecipitation of ERK tagged with hemagglutinin (HA) or FLAG epitopes with an IC50 value of approximately 0.5 μM without affecting ERK phosphorylation or kinase activity (IC50s = >10 μM).{37660} It inhibits cell growth in a panel of melanoma and colorectal cancer cell lines (IC50s = 150-400 nM). DEL-22379 (15 mg/kg, i.p.) inhibits ERK dimerization in liver extract and tumor tissue and inhibits tumor progression in an A375 mouse xenograft model. It also reduces tumor growth in a BRAF mutant colorectal cancer patient-derived xenograft (PDX) mouse model.
Brand:CaymanSKU:22433 -Out of stock
DEL-22379 is an inhibitor of ERK dimerization that disrupts EGF-induced co-immunoprecipitation of ERK tagged with hemagglutinin (HA) or FLAG epitopes with an IC50 value of approximately 0.5 μM without affecting ERK phosphorylation or kinase activity (IC50s = >10 μM).{37660} It inhibits cell growth in a panel of melanoma and colorectal cancer cell lines (IC50s = 150-400 nM). DEL-22379 (15 mg/kg, i.p.) inhibits ERK dimerization in liver extract and tumor tissue and inhibits tumor progression in an A375 mouse xenograft model. It also reduces tumor growth in a BRAF mutant colorectal cancer patient-derived xenograft (PDX) mouse model.
Brand:CaymanSKU:22433 -Out of stock
Delafloxacin is a fluoroquinolone antibiotic that demonstrates extremely high potency against a wide range of bacteria in vitro, including levofloxacin-resistant strains of S. pneumoniae and methicillin-resistant S. aureus.{32844,32846} It targets both DNA gyrase and topoisomerase IV. Delafloxacin has an anionic structure, which enhances its potency in acidic environments (e.g., phagolysosome, inflammatory cells) and in skin and soft tissue infections.{32845}
Brand:CaymanSKU:20314 -Available on backorder
Delafloxacin is a fluoroquinolone antibiotic that demonstrates extremely high potency against a wide range of bacteria in vitro, including levofloxacin-resistant strains of S. pneumoniae and methicillin-resistant S. aureus.{32844,32846} It targets both DNA gyrase and topoisomerase IV. Delafloxacin has an anionic structure, which enhances its potency in acidic environments (e.g., phagolysosome, inflammatory cells) and in skin and soft tissue infections.{32845}
Brand:CaymanSKU:20314 -Available on backorder
Delafloxacin is a fluoroquinolone antibiotic that demonstrates extremely high potency against a wide range of bacteria in vitro, including levofloxacin-resistant strains of S. pneumoniae and methicillin-resistant S. aureus.{32844,32846} It targets both DNA gyrase and topoisomerase IV. Delafloxacin has an anionic structure, which enhances its potency in acidic environments (e.g., phagolysosome, inflammatory cells) and in skin and soft tissue infections.{32845}
Brand:CaymanSKU:20314 -Available on backorder
Delafloxacin is a fluoroquinolone antibiotic that demonstrates extremely high potency against a wide range of bacteria in vitro, including levofloxacin-resistant strains of S. pneumoniae and methicillin-resistant S. aureus.{32844,32846} It targets both DNA gyrase and topoisomerase IV. Delafloxacin has an anionic structure, which enhances its potency in acidic environments (e.g., phagolysosome, inflammatory cells) and in skin and soft tissue infections.{32845}
Brand:CaymanSKU:20314 -Available on backorder
Delafloxacin is a broad-spectrum fluoroquinolone antibiotic.{32846} It is active against S. aureus, S. epidermidis, S. pneumoniae, S. pyogenes, E. faecalis, E. faecium, L. monocytogenes, E. coli, Salmonella, Shigella, C. freundii, Klebsiella, P. mirabilis, S. marcescens, S. maltophilia, H. influenzae, M. catarrhalis, N. gonorrhoeae, C. difficile, and C. perfringens in vitro (MICs = S. aureus and S. pneumoniae lung infection.{35894} Formulations containing delafloxacin have been used in the treatment of acute bacterial skin and skin structure infections.
Brand:CaymanSKU:27935 - 10 mgAvailable on backorder
Delafloxacin is a broad-spectrum fluoroquinolone antibiotic.{32846} It is active against S. aureus, S. epidermidis, S. pneumoniae, S. pyogenes, E. faecalis, E. faecium, L. monocytogenes, E. coli, Salmonella, Shigella, C. freundii, Klebsiella, P. mirabilis, S. marcescens, S. maltophilia, H. influenzae, M. catarrhalis, N. gonorrhoeae, C. difficile, and C. perfringens in vitro (MICs = S. aureus and S. pneumoniae lung infection.{35894} Formulations containing delafloxacin have been used in the treatment of acute bacterial skin and skin structure infections.
Brand:CaymanSKU:27935 - 100 mgAvailable on backorder
Delafloxacin is a broad-spectrum fluoroquinolone antibiotic.{32846} It is active against S. aureus, S. epidermidis, S. pneumoniae, S. pyogenes, E. faecalis, E. faecium, L. monocytogenes, E. coli, Salmonella, Shigella, C. freundii, Klebsiella, P. mirabilis, S. marcescens, S. maltophilia, H. influenzae, M. catarrhalis, N. gonorrhoeae, C. difficile, and C. perfringens in vitro (MICs = S. aureus and S. pneumoniae lung infection.{35894} Formulations containing delafloxacin have been used in the treatment of acute bacterial skin and skin structure infections.
Brand:CaymanSKU:27935 - 250 mgAvailable on backorder
Delafloxacin is a broad-spectrum fluoroquinolone antibiotic.{32846} It is active against S. aureus, S. epidermidis, S. pneumoniae, S. pyogenes, E. faecalis, E. faecium, L. monocytogenes, E. coli, Salmonella, Shigella, C. freundii, Klebsiella, P. mirabilis, S. marcescens, S. maltophilia, H. influenzae, M. catarrhalis, N. gonorrhoeae, C. difficile, and C. perfringens in vitro (MICs = S. aureus and S. pneumoniae lung infection.{35894} Formulations containing delafloxacin have been used in the treatment of acute bacterial skin and skin structure infections.
Brand:CaymanSKU:27935 - 50 mgAvailable on backorder
Delamanid is an antimycobacterial compound.{46718} It is active against clinical isolates of M. tuberculosis that are susceptible (MIC90s = 0.01194-0.01248 μg/ml) or resistant to rifampicin (Item No. 14423), isoniazid (Item No. 20378), ethambutol (Item No. 23713), and/or streptomycin (Item No. 21211; MIC90s = 0.01221-0.01341 μg/ml). It inhibits the synthesis of methoxy- and keto-mycolic acid in the M. bovis strain BCG (IC50s = 0.036 and 0.021 μg/ml, respectively). Delamanid (0.1, 0.3, and 1 μg/ml) inhibits the growth of the M. tuberculosis strain H37Rv in infected THP-1 cells. It decreases lung bacterial burden in a mouse model of M. tuberculosis infection in a dose-dependent manner.
Brand:CaymanSKU:29697 - 10 mgAvailable on backorder
Delamanid is an antimycobacterial compound.{46718} It is active against clinical isolates of M. tuberculosis that are susceptible (MIC90s = 0.01194-0.01248 μg/ml) or resistant to rifampicin (Item No. 14423), isoniazid (Item No. 20378), ethambutol (Item No. 23713), and/or streptomycin (Item No. 21211; MIC90s = 0.01221-0.01341 μg/ml). It inhibits the synthesis of methoxy- and keto-mycolic acid in the M. bovis strain BCG (IC50s = 0.036 and 0.021 μg/ml, respectively). Delamanid (0.1, 0.3, and 1 μg/ml) inhibits the growth of the M. tuberculosis strain H37Rv in infected THP-1 cells. It decreases lung bacterial burden in a mouse model of M. tuberculosis infection in a dose-dependent manner.
Brand:CaymanSKU:29697 - 100 mgAvailable on backorder
Delamanid is an antimycobacterial compound.{46718} It is active against clinical isolates of M. tuberculosis that are susceptible (MIC90s = 0.01194-0.01248 μg/ml) or resistant to rifampicin (Item No. 14423), isoniazid (Item No. 20378), ethambutol (Item No. 23713), and/or streptomycin (Item No. 21211; MIC90s = 0.01221-0.01341 μg/ml). It inhibits the synthesis of methoxy- and keto-mycolic acid in the M. bovis strain BCG (IC50s = 0.036 and 0.021 μg/ml, respectively). Delamanid (0.1, 0.3, and 1 μg/ml) inhibits the growth of the M. tuberculosis strain H37Rv in infected THP-1 cells. It decreases lung bacterial burden in a mouse model of M. tuberculosis infection in a dose-dependent manner.
Brand:CaymanSKU:29697 - 250 mgAvailable on backorder
Delamanid is an antimycobacterial compound.{46718} It is active against clinical isolates of M. tuberculosis that are susceptible (MIC90s = 0.01194-0.01248 μg/ml) or resistant to rifampicin (Item No. 14423), isoniazid (Item No. 20378), ethambutol (Item No. 23713), and/or streptomycin (Item No. 21211; MIC90s = 0.01221-0.01341 μg/ml). It inhibits the synthesis of methoxy- and keto-mycolic acid in the M. bovis strain BCG (IC50s = 0.036 and 0.021 μg/ml, respectively). Delamanid (0.1, 0.3, and 1 μg/ml) inhibits the growth of the M. tuberculosis strain H37Rv in infected THP-1 cells. It decreases lung bacterial burden in a mouse model of M. tuberculosis infection in a dose-dependent manner.
Brand:CaymanSKU:29697 - 50 mgAvailable on backorder
Delanzomib is an orally bioavailable inhibitor of chymotrypsin-like proteasome activity (IC50 = 3.8 nM in isolated human erythrocytes) that only marginally inhibits tryptic and peptidyl glutamyl proteasome activity.{41359} Delanzomib pre-treatment (20 nM) in vitro inhibits IκBα degradation, NF-κB activation, and the expression of NF-κB-regulated genes, including IκBα, XIAP, TNF-α, IL-1β, ICAM-1, and VEGF. Delanzomib induces apoptosis in multiple myeloma cell lines and inhibits proliferation in a panel of human hematologic and solid tumor cell lines (IC50s = 5.6-34.2 nM). It reduces tumor weight in an RPMI 8226 human multiple myeloma mouse xenograft model when administered intravenously at doses ranging from 1.5-4 mg/kg twice daily and leads to complete tumor regression at a chronic oral dose of 13 mg/kg. Delanzomib reduces the serum level of circulating cytokines, prevents renal tissue damage, and increases lifespan in a mouse model of fatal lupus nephritis. {41360}
Brand:CaymanSKU:23557 - 1 mgAvailable on backorder
Delanzomib is an orally bioavailable inhibitor of chymotrypsin-like proteasome activity (IC50 = 3.8 nM in isolated human erythrocytes) that only marginally inhibits tryptic and peptidyl glutamyl proteasome activity.{41359} Delanzomib pre-treatment (20 nM) in vitro inhibits IκBα degradation, NF-κB activation, and the expression of NF-κB-regulated genes, including IκBα, XIAP, TNF-α, IL-1β, ICAM-1, and VEGF. Delanzomib induces apoptosis in multiple myeloma cell lines and inhibits proliferation in a panel of human hematologic and solid tumor cell lines (IC50s = 5.6-34.2 nM). It reduces tumor weight in an RPMI 8226 human multiple myeloma mouse xenograft model when administered intravenously at doses ranging from 1.5-4 mg/kg twice daily and leads to complete tumor regression at a chronic oral dose of 13 mg/kg. Delanzomib reduces the serum level of circulating cytokines, prevents renal tissue damage, and increases lifespan in a mouse model of fatal lupus nephritis. {41360}
Brand:CaymanSKU:23557 - 10 mgAvailable on backorder
Delanzomib is an orally bioavailable inhibitor of chymotrypsin-like proteasome activity (IC50 = 3.8 nM in isolated human erythrocytes) that only marginally inhibits tryptic and peptidyl glutamyl proteasome activity.{41359} Delanzomib pre-treatment (20 nM) in vitro inhibits IκBα degradation, NF-κB activation, and the expression of NF-κB-regulated genes, including IκBα, XIAP, TNF-α, IL-1β, ICAM-1, and VEGF. Delanzomib induces apoptosis in multiple myeloma cell lines and inhibits proliferation in a panel of human hematologic and solid tumor cell lines (IC50s = 5.6-34.2 nM). It reduces tumor weight in an RPMI 8226 human multiple myeloma mouse xenograft model when administered intravenously at doses ranging from 1.5-4 mg/kg twice daily and leads to complete tumor regression at a chronic oral dose of 13 mg/kg. Delanzomib reduces the serum level of circulating cytokines, prevents renal tissue damage, and increases lifespan in a mouse model of fatal lupus nephritis. {41360}
Brand:CaymanSKU:23557 - 5 mgAvailable on backorder
Delanzomib is an orally bioavailable inhibitor of chymotrypsin-like proteasome activity (IC50 = 3.8 nM in isolated human erythrocytes) that only marginally inhibits tryptic and peptidyl glutamyl proteasome activity.{41359} Delanzomib pre-treatment (20 nM) in vitro inhibits IκBα degradation, NF-κB activation, and the expression of NF-κB-regulated genes, including IκBα, XIAP, TNF-α, IL-1β, ICAM-1, and VEGF. Delanzomib induces apoptosis in multiple myeloma cell lines and inhibits proliferation in a panel of human hematologic and solid tumor cell lines (IC50s = 5.6-34.2 nM). It reduces tumor weight in an RPMI 8226 human multiple myeloma mouse xenograft model when administered intravenously at doses ranging from 1.5-4 mg/kg twice daily and leads to complete tumor regression at a chronic oral dose of 13 mg/kg. Delanzomib reduces the serum level of circulating cytokines, prevents renal tissue damage, and increases lifespan in a mouse model of fatal lupus nephritis. {41360}
Brand:CaymanSKU:23557 - 50 mgAvailable on backorder
Delavirdine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that selectively inhibits HIV-1 reverse transcriptase over DNA polymerase α and δ in vitro (IC50s = 0.26, 440, and >550 μM, respectively).{40767} It inhibits growth of clinical isolates of HIV-1 (ED50s = 50 value of 0.066 μM. Delavirdine also inhibits growth of L. infantum promastigotes (IC50 = 26.1 μM).{40768} Formulations containing delavirdine have been used in the treatment of HIV.
Brand:CaymanSKU:24026 - 1 mgAvailable on backorder
Delavirdine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that selectively inhibits HIV-1 reverse transcriptase over DNA polymerase α and δ in vitro (IC50s = 0.26, 440, and >550 μM, respectively).{40767} It inhibits growth of clinical isolates of HIV-1 (ED50s = 50 value of 0.066 μM. Delavirdine also inhibits growth of L. infantum promastigotes (IC50 = 26.1 μM).{40768} Formulations containing delavirdine have been used in the treatment of HIV.
Brand:CaymanSKU:24026 - 10 mgAvailable on backorder
Delavirdine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that selectively inhibits HIV-1 reverse transcriptase over DNA polymerase α and δ in vitro (IC50s = 0.26, 440, and >550 μM, respectively).{40767} It inhibits growth of clinical isolates of HIV-1 (ED50s = 50 value of 0.066 μM. Delavirdine also inhibits growth of L. infantum promastigotes (IC50 = 26.1 μM).{40768} Formulations containing delavirdine have been used in the treatment of HIV.
Brand:CaymanSKU:24026 - 25 mgAvailable on backorder
Delavirdine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that selectively inhibits HIV-1 reverse transcriptase over DNA polymerase α and δ in vitro (IC50s = 0.26, 440, and >550 μM, respectively).{40767} It inhibits growth of clinical isolates of HIV-1 (ED50s = 50 value of 0.066 μM. Delavirdine also inhibits growth of L. infantum promastigotes (IC50 = 26.1 μM).{40768} Formulations containing delavirdine have been used in the treatment of HIV.
Brand:CaymanSKU:24026 - 5 mgAvailable on backorder
Delpazolid is an oxazolidinone antibiotic.{48191} It is active against a wide range of Gram-positive bacterial clinical isolates, including resistant strains of several species, such as methicillin-resistant S. aureus (MRSA), methicillin-resistant coagulase-negative staphylococci (MRCNS), and penicillin-resistant S. pneumoniae (MICs = 0.125-4 μg/ml). Delpazolid increases survival in mouse models of systemic MRSA, E. faecalis, S. pneumoniae, and H. influenzae infection (ED50s = 2.96, 4.53, 2.28, and 9.96 mg/kg, respectively).
Brand:CaymanSKU:25532 - 1 mgAvailable on backorder
Delpazolid is an oxazolidinone antibiotic.{48191} It is active against a wide range of Gram-positive bacterial clinical isolates, including resistant strains of several species, such as methicillin-resistant S. aureus (MRSA), methicillin-resistant coagulase-negative staphylococci (MRCNS), and penicillin-resistant S. pneumoniae (MICs = 0.125-4 μg/ml). Delpazolid increases survival in mouse models of systemic MRSA, E. faecalis, S. pneumoniae, and H. influenzae infection (ED50s = 2.96, 4.53, 2.28, and 9.96 mg/kg, respectively).
Brand:CaymanSKU:25532 - 10 mgAvailable on backorder
Delpazolid is an oxazolidinone antibiotic.{48191} It is active against a wide range of Gram-positive bacterial clinical isolates, including resistant strains of several species, such as methicillin-resistant S. aureus (MRSA), methicillin-resistant coagulase-negative staphylococci (MRCNS), and penicillin-resistant S. pneumoniae (MICs = 0.125-4 μg/ml). Delpazolid increases survival in mouse models of systemic MRSA, E. faecalis, S. pneumoniae, and H. influenzae infection (ED50s = 2.96, 4.53, 2.28, and 9.96 mg/kg, respectively).
Brand:CaymanSKU:25532 - 25 mgAvailable on backorder
Delpazolid is an oxazolidinone antibiotic.{48191} It is active against a wide range of Gram-positive bacterial clinical isolates, including resistant strains of several species, such as methicillin-resistant S. aureus (MRSA), methicillin-resistant coagulase-negative staphylococci (MRCNS), and penicillin-resistant S. pneumoniae (MICs = 0.125-4 μg/ml). Delpazolid increases survival in mouse models of systemic MRSA, E. faecalis, S. pneumoniae, and H. influenzae infection (ED50s = 2.96, 4.53, 2.28, and 9.96 mg/kg, respectively).
Brand:CaymanSKU:25532 - 5 mgAvailable on backorder
Delphinidin (chloride) is an anthocyanidin, a natural plant pigment which serves as the precursor of certain anthocyanins that provide the blue-red colors of flowers, fruits, and red wine.{20650} Delphinidin induces the release of nitric oxide by vascular endothelium, causing vasorelaxation.{20649} It also inhibits signaling through epithelial growth factor receptors, suppressing the expression of estrogen receptor α and inducing both apoptosis and autophagy at a dose of 1-40 μM.{20651,20648} Delphinidin also inhibits the histone acetyltransferase activities of p300/CBP (IC50 = ~ 30 μM).{19795}
Brand:CaymanSKU:11012 - 1 mgAvailable on backorder
Delphinidin (chloride) is an anthocyanidin, a natural plant pigment which serves as the precursor of certain anthocyanins that provide the blue-red colors of flowers, fruits, and red wine.{20650} Delphinidin induces the release of nitric oxide by vascular endothelium, causing vasorelaxation.{20649} It also inhibits signaling through epithelial growth factor receptors, suppressing the expression of estrogen receptor α and inducing both apoptosis and autophagy at a dose of 1-40 μM.{20651,20648} Delphinidin also inhibits the histone acetyltransferase activities of p300/CBP (IC50 = ~ 30 μM).{19795}
Brand:CaymanSKU:11012 - 10 mgAvailable on backorder
Delphinidin (chloride) is an anthocyanidin, a natural plant pigment which serves as the precursor of certain anthocyanins that provide the blue-red colors of flowers, fruits, and red wine.{20650} Delphinidin induces the release of nitric oxide by vascular endothelium, causing vasorelaxation.{20649} It also inhibits signaling through epithelial growth factor receptors, suppressing the expression of estrogen receptor α and inducing both apoptosis and autophagy at a dose of 1-40 μM.{20651,20648} Delphinidin also inhibits the histone acetyltransferase activities of p300/CBP (IC50 = ~ 30 μM).{19795}
Brand:CaymanSKU:11012 - 5 mgAvailable on backorder
Delsoline is a diterpene alkaloid that has been found in Delphinium and has diverse biological activities.{61115,61116,61117} It inhibits binding of α-bungarotoxin (Item No. 16385) to rat neuronal α7 nicotinic acetylcholine receptors (nAChRs; IC50 = 19 µM).{61115} Delsoline (3 mg/ml) is repellent against adult red flour beetles (T. castaneum) in a filter paper assay.{61116} In vivo, delsoline (75 mg/kg) lowers systolic blood pressure in a rat model of left renal artery ligation-induced hypertension.{61117}
Brand:CaymanSKU:31748 - 1 mgAvailable on backorder
Delsoline is a diterpene alkaloid that has been found in Delphinium and has diverse biological activities.{61115,61116,61117} It inhibits binding of α-bungarotoxin (Item No. 16385) to rat neuronal α7 nicotinic acetylcholine receptors (nAChRs; IC50 = 19 µM).{61115} Delsoline (3 mg/ml) is repellent against adult red flour beetles (T. castaneum) in a filter paper assay.{61116} In vivo, delsoline (75 mg/kg) lowers systolic blood pressure in a rat model of left renal artery ligation-induced hypertension.{61117}
Brand:CaymanSKU:31748 - 10 mgAvailable on backorder
Delsoline is a diterpene alkaloid that has been found in Delphinium and has diverse biological activities.{61115,61116,61117} It inhibits binding of α-bungarotoxin (Item No. 16385) to rat neuronal α7 nicotinic acetylcholine receptors (nAChRs; IC50 = 19 µM).{61115} Delsoline (3 mg/ml) is repellent against adult red flour beetles (T. castaneum) in a filter paper assay.{61116} In vivo, delsoline (75 mg/kg) lowers systolic blood pressure in a rat model of left renal artery ligation-induced hypertension.{61117}
Brand:CaymanSKU:31748 - 5 mgAvailable on backorder
Deltamethrin is a type II pyrethroid insecticide and a modulator of voltage-gated sodium channels (Nav).{36375} It binds to Drosophila para Nav channels in a use-dependent manner following brief depolarizing prepulses and with increasing concentrations of 1 to 5 nM, indicating that it preferentially binds to the channel in the open state.{41828} It slowly activates Nav1.8 channels, delays inactivation by longer than 40 ms, and induces persistent tail currents for channels expressed in X. laevis oocytes.{36375} Deltamethrin decreases proliferation of MCF-7 cells and inhibits androgen receptor transactivation when used at concentrations of 10 and 20 µM or greater, respectively. However, it is not cytotoxic to MCF-7 and CHO cells at concentrations of 25 and 100 µM, respectively, and does not induce transactivation of the estrogen receptor.{41692} Deltamethrin is lethal to mice with an LD50 value of 50 mg/kg and at low sublethal doses of 0.05 and 0.1 mg/kg it induces histopathological changes in the liver, kidney, spleen, and testes, including a loss of spermatozoa and Sertoli cells.{41829}
Brand:CaymanSKU:24172 - 100 mgAvailable on backorder
Deltamethrin is a type II pyrethroid insecticide and a modulator of voltage-gated sodium channels (Nav).{36375} It binds to Drosophila para Nav channels in a use-dependent manner following brief depolarizing prepulses and with increasing concentrations of 1 to 5 nM, indicating that it preferentially binds to the channel in the open state.{41828} It slowly activates Nav1.8 channels, delays inactivation by longer than 40 ms, and induces persistent tail currents for channels expressed in X. laevis oocytes.{36375} Deltamethrin decreases proliferation of MCF-7 cells and inhibits androgen receptor transactivation when used at concentrations of 10 and 20 µM or greater, respectively. However, it is not cytotoxic to MCF-7 and CHO cells at concentrations of 25 and 100 µM, respectively, and does not induce transactivation of the estrogen receptor.{41692} Deltamethrin is lethal to mice with an LD50 value of 50 mg/kg and at low sublethal doses of 0.05 and 0.1 mg/kg it induces histopathological changes in the liver, kidney, spleen, and testes, including a loss of spermatozoa and Sertoli cells.{41829}
Brand:CaymanSKU:24172 - 50 mgAvailable on backorder
KRAS is an oncogene product that acts as a GTPase tethered to cell membranes to assist in various cell signaling pathways. The prenyl-binding protein PDEδ regulates the correct localization and signaling of farnesylated KRAS by facilitating its diffusion to the cytoplasm. Deltarasin is a small molecule that binds to the farnesyl-binding pocket of PDEδ (Kd = 41 nM) in cells thus inhibiting its interaction with KRAS and disrupting RAS signaling.{25383} Treatment of human pancreatic ductal adenocarcinoma cell models with 5 μM deltarasin has been reported to prevent KRAS plasma membrane localization and subsequent solubilization by PDEδ, resulting in reduced proliferation and increased cell death of Panc-Tu-I tumor cells.{25383} Furthermore, in nude mice bearing pancreatic carcinoma xenografts, deltarasin has been shown to reduce tumor growth at a dose of 10 mg/kg.{25383}
Brand:CaymanSKU:9001536 - 1 mgAvailable on backorder
KRAS is an oncogene product that acts as a GTPase tethered to cell membranes to assist in various cell signaling pathways. The prenyl-binding protein PDEδ regulates the correct localization and signaling of farnesylated KRAS by facilitating its diffusion to the cytoplasm. Deltarasin is a small molecule that binds to the farnesyl-binding pocket of PDEδ (Kd = 41 nM) in cells thus inhibiting its interaction with KRAS and disrupting RAS signaling.{25383} Treatment of human pancreatic ductal adenocarcinoma cell models with 5 μM deltarasin has been reported to prevent KRAS plasma membrane localization and subsequent solubilization by PDEδ, resulting in reduced proliferation and increased cell death of Panc-Tu-I tumor cells.{25383} Furthermore, in nude mice bearing pancreatic carcinoma xenografts, deltarasin has been shown to reduce tumor growth at a dose of 10 mg/kg.{25383}
Brand:CaymanSKU:9001536 - 10 mgAvailable on backorder
KRAS is an oncogene product that acts as a GTPase tethered to cell membranes to assist in various cell signaling pathways. The prenyl-binding protein PDEδ regulates the correct localization and signaling of farnesylated KRAS by facilitating its diffusion to the cytoplasm. Deltarasin is a small molecule that binds to the farnesyl-binding pocket of PDEδ (Kd = 41 nM) in cells thus inhibiting its interaction with KRAS and disrupting RAS signaling.{25383} Treatment of human pancreatic ductal adenocarcinoma cell models with 5 μM deltarasin has been reported to prevent KRAS plasma membrane localization and subsequent solubilization by PDEδ, resulting in reduced proliferation and increased cell death of Panc-Tu-I tumor cells.{25383} Furthermore, in nude mice bearing pancreatic carcinoma xenografts, deltarasin has been shown to reduce tumor growth at a dose of 10 mg/kg.{25383}
Brand:CaymanSKU:9001536 - 5 mgAvailable on backorder
Demeclocycline is a broad-spectrum tetracycline antibiotic produced by S. aureofaciens.{40080} It has antimicrobial activity against ~3,200 pathogenic Gram-positive and Gram-negative bacteria in vitro that is 2-fold greater than that of tetracycline (Item No. 14328). The bactericidal action of demeclocycline is comparable to that of chlortetracycline but the duration of action is longer due to its resistance to degradation by acids or alkalis. It is effective against S. pyogenes and K. pneumoniae infections in vivo when administered orally or subcutaneously in mice. Demeclocycline decreases aquaporin 2 (AQP2) water channel gene transcription and protein abundance in mpkCCD murine collecting duct cells in a dose-dependent manner.{40081} It also increases urine volume, decreases urine osmolity, and increases fractional excretion of water in a rat model of hyponatremia. Formulations containing demeclocycline have been used to treat hyponatremia due to syndrome of inappropriate antidiuretic hormone secretion (SIADH) and as endodontic antibiotics to prevent infection following root canal procedures.{40082,40083}
Brand:CaymanSKU:21759 -Out of stock
Demeclocycline is a broad-spectrum tetracycline antibiotic produced by S. aureofaciens.{40080} It has antimicrobial activity against ~3,200 pathogenic Gram-positive and Gram-negative bacteria in vitro that is 2-fold greater than that of tetracycline (Item No. 14328). The bactericidal action of demeclocycline is comparable to that of chlortetracycline but the duration of action is longer due to its resistance to degradation by acids or alkalis. It is effective against S. pyogenes and K. pneumoniae infections in vivo when administered orally or subcutaneously in mice. Demeclocycline decreases aquaporin 2 (AQP2) water channel gene transcription and protein abundance in mpkCCD murine collecting duct cells in a dose-dependent manner.{40081} It also increases urine volume, decreases urine osmolity, and increases fractional excretion of water in a rat model of hyponatremia. Formulations containing demeclocycline have been used to treat hyponatremia due to syndrome of inappropriate antidiuretic hormone secretion (SIADH) and as endodontic antibiotics to prevent infection following root canal procedures.{40082,40083}
Brand:CaymanSKU:21759 -Out of stock
Demethoxycurcumin (DMC) is a natural demethoxy derivative of curcumin. More stable than curcumin in physiological media, DMC suppresses proliferation in cancer cells at 50-100 μM.{19787} It down-regulates the transcriptional coactivator p300, suppressing the Wnt/β-catenin pathway, and inhibits lipopolysaccharide induction of iNOS.{19784}
Brand:CaymanSKU:10961 - 1 mgAvailable on backorder
Demethoxycurcumin (DMC) is a natural demethoxy derivative of curcumin. More stable than curcumin in physiological media, DMC suppresses proliferation in cancer cells at 50-100 μM.{19787} It down-regulates the transcriptional coactivator p300, suppressing the Wnt/β-catenin pathway, and inhibits lipopolysaccharide induction of iNOS.{19784}
Brand:CaymanSKU:10961 - 10 mgAvailable on backorder
Demethoxycurcumin (DMC) is a natural demethoxy derivative of curcumin. More stable than curcumin in physiological media, DMC suppresses proliferation in cancer cells at 50-100 μM.{19787} It down-regulates the transcriptional coactivator p300, suppressing the Wnt/β-catenin pathway, and inhibits lipopolysaccharide induction of iNOS.{19784}
Brand:CaymanSKU:10961 - 25 mgAvailable on backorder
Demethoxycurcumin (DMC) is a natural demethoxy derivative of curcumin. More stable than curcumin in physiological media, DMC suppresses proliferation in cancer cells at 50-100 μM.{19787} It down-regulates the transcriptional coactivator p300, suppressing the Wnt/β-catenin pathway, and inhibits lipopolysaccharide induction of iNOS.{19784}
Brand:CaymanSKU:10961 - 5 mgAvailable on backorder
Demethoxyviridiol is a mycotoxin originally isolated from N. hinnuleum.{47358} It induces lethality in day-old cockerels (LD50 = 4.2 mg/kg). Demethoxyviridiol is also an inhibitor of phosphatidylinositol 3-kinase (PI3K).{31278}
Brand:CaymanSKU:27953 - 1 mgAvailable on backorder
Demethoxyviridiol is a mycotoxin originally isolated from N. hinnuleum.{47358} It induces lethality in day-old cockerels (LD50 = 4.2 mg/kg). Demethoxyviridiol is also an inhibitor of phosphatidylinositol 3-kinase (PI3K).{31278}
Brand:CaymanSKU:27953 - 5 mgAvailable on backorder
Demethylasterriquinone B1 (DMAQ B1) is a natural insulin mimic that activates insulin receptor tyrosine kinase (IRTK; EC50 = 6 µM).{33106,33107,33108,33109} It less potently activates IGF1R and EGFR (EC50s = 100 µM for both). DMAQ B1 induces glucose uptake in adipocytes and skeletal muscle cells without activating proliferation. DMAQ B1 binds GAPDH in vitro.{33105}
Brand:CaymanSKU:21026 -Out of stock
Demethylasterriquinone B1 (DMAQ B1) is a natural insulin mimic that activates insulin receptor tyrosine kinase (IRTK; EC50 = 6 µM).{33106,33107,33108,33109} It less potently activates IGF1R and EGFR (EC50s = 100 µM for both). DMAQ B1 induces glucose uptake in adipocytes and skeletal muscle cells without activating proliferation. DMAQ B1 binds GAPDH in vitro.{33105}
Brand:CaymanSKU:21026 -Out of stock
Demethylwedelolactone (DWL) is a coumestan, originally isolated from E. alba, with diverse biological activities.{40154,40155,40156,40157} It reduces cytotoxicity induced by CCL4 and galactosamine (GaIN; Item No. 22981) in rat hepatocytes in a dose-dependent manner.{40154} DWL inhibits trypsin with an IC50 value of 3.0 μg/ml in vitro.{40155} It is the major constituent in purified butanolic extracts of E. prostrata which inhibit lethal and hemorrhagic activities of C. rhodostoma venom.{40156} DWL also inhibits anchorage-independent cell growth of MDA-MB-231 breast cancer cells and decreases the number of lung metastases in an MDA-MB-231 xenograft model in nude mice.{40157}
Brand:CaymanSKU:11703 - 1 mgAvailable on backorder
Demethylwedelolactone (DWL) is a coumestan, originally isolated from E. alba, with diverse biological activities.{40154,40155,40156,40157} It reduces cytotoxicity induced by CCL4 and galactosamine (GaIN; Item No. 22981) in rat hepatocytes in a dose-dependent manner.{40154} DWL inhibits trypsin with an IC50 value of 3.0 μg/ml in vitro.{40155} It is the major constituent in purified butanolic extracts of E. prostrata which inhibit lethal and hemorrhagic activities of C. rhodostoma venom.{40156} DWL also inhibits anchorage-independent cell growth of MDA-MB-231 breast cancer cells and decreases the number of lung metastases in an MDA-MB-231 xenograft model in nude mice.{40157}
Brand:CaymanSKU:11703 - 10 mgAvailable on backorder
Demethylwedelolactone (DWL) is a coumestan, originally isolated from E. alba, with diverse biological activities.{40154,40155,40156,40157} It reduces cytotoxicity induced by CCL4 and galactosamine (GaIN; Item No. 22981) in rat hepatocytes in a dose-dependent manner.{40154} DWL inhibits trypsin with an IC50 value of 3.0 μg/ml in vitro.{40155} It is the major constituent in purified butanolic extracts of E. prostrata which inhibit lethal and hemorrhagic activities of C. rhodostoma venom.{40156} DWL also inhibits anchorage-independent cell growth of MDA-MB-231 breast cancer cells and decreases the number of lung metastases in an MDA-MB-231 xenograft model in nude mice.{40157}
Brand:CaymanSKU:11703 - 5 mgAvailable on backorder
Demethylwedelolactone (DWL) is a coumestan, originally isolated from E. alba, with diverse biological activities.{40154,40155,40156,40157} It reduces cytotoxicity induced by CCL4 and galactosamine (GaIN; Item No. 22981) in rat hepatocytes in a dose-dependent manner.{40154} DWL inhibits trypsin with an IC50 value of 3.0 μg/ml in vitro.{40155} It is the major constituent in purified butanolic extracts of E. prostrata which inhibit lethal and hemorrhagic activities of C. rhodostoma venom.{40156} DWL also inhibits anchorage-independent cell growth of MDA-MB-231 breast cancer cells and decreases the number of lung metastases in an MDA-MB-231 xenograft model in nude mice.{40157}
Brand:CaymanSKU:11703 - 500 µgAvailable on backorder
Demethylzeylasteral is a nortriterpenoid originally isolated from T. wilfordii that has diverse biological activities, including enzyme inhibitory, anti-angiogenic, antiproliferative, anti-inflammatory, and immunosuppressive properties.{45479,45480,45481,45482} Demethylzeylasteral inhibits the UDP-glucuronosyltransferase (UGT) isoforms UGT1A6 and UGT2B7 (Kis = 0.6 and 17.3 μM, respectively).{45480} It inhibits growth of bovine aortic endothelial cells (BAEs) and U251 human glioma cancer cells in vitro (IC50s = 0.21 and ~6.2 μM, respectively), as well as inhibits tumor growth and neovascularization in vivo in a B16/F10 melanoma mouse allograft model when administered at a dose of 30 mg/kg per day.{45479} Demethylzeylasteral (0.12 mg/kg per day) decreases renal proteinuria, lesions, immune cell infiltration, and protein levels of TNF-α, COX-2, and ICAM-1 in lupus-prone MRL/lpr mice.{45481} Demethylzeylasteral (10 mg/kg per day) also increases survival of recipient rats in a model of kidney transplant.{45482}
Brand:CaymanSKU:28595 - 1 mgAvailable on backorder
Demethylzeylasteral is a nortriterpenoid originally isolated from T. wilfordii that has diverse biological activities, including enzyme inhibitory, anti-angiogenic, antiproliferative, anti-inflammatory, and immunosuppressive properties.{45479,45480,45481,45482} Demethylzeylasteral inhibits the UDP-glucuronosyltransferase (UGT) isoforms UGT1A6 and UGT2B7 (Kis = 0.6 and 17.3 μM, respectively).{45480} It inhibits growth of bovine aortic endothelial cells (BAEs) and U251 human glioma cancer cells in vitro (IC50s = 0.21 and ~6.2 μM, respectively), as well as inhibits tumor growth and neovascularization in vivo in a B16/F10 melanoma mouse allograft model when administered at a dose of 30 mg/kg per day.{45479} Demethylzeylasteral (0.12 mg/kg per day) decreases renal proteinuria, lesions, immune cell infiltration, and protein levels of TNF-α, COX-2, and ICAM-1 in lupus-prone MRL/lpr mice.{45481} Demethylzeylasteral (10 mg/kg per day) also increases survival of recipient rats in a model of kidney transplant.{45482}
Brand:CaymanSKU:28595 - 10 mgAvailable on backorder
Demethylzeylasteral is a nortriterpenoid originally isolated from T. wilfordii that has diverse biological activities, including enzyme inhibitory, anti-angiogenic, antiproliferative, anti-inflammatory, and immunosuppressive properties.{45479,45480,45481,45482} Demethylzeylasteral inhibits the UDP-glucuronosyltransferase (UGT) isoforms UGT1A6 and UGT2B7 (Kis = 0.6 and 17.3 μM, respectively).{45480} It inhibits growth of bovine aortic endothelial cells (BAEs) and U251 human glioma cancer cells in vitro (IC50s = 0.21 and ~6.2 μM, respectively), as well as inhibits tumor growth and neovascularization in vivo in a B16/F10 melanoma mouse allograft model when administered at a dose of 30 mg/kg per day.{45479} Demethylzeylasteral (0.12 mg/kg per day) decreases renal proteinuria, lesions, immune cell infiltration, and protein levels of TNF-α, COX-2, and ICAM-1 in lupus-prone MRL/lpr mice.{45481} Demethylzeylasteral (10 mg/kg per day) also increases survival of recipient rats in a model of kidney transplant.{45482}
Brand:CaymanSKU:28595 - 5 mgAvailable on backorder
Denatonium (benzoate salt) (Item No. 26350) is an analytical reference standard categorized as a bittering agent.{42560} Formulations containing denatonium have been used as bittering agents to reduce ingestion of toxic substances by children. This product is intended for research and forensic applications.
Brand:CaymanSKU:26350 - 5 mgAvailable on backorder
Dendrobine is a sesquiterpenoid that has been found in D. nobile and has anticancer activity.{46864,46865} It decreases viability of A549 cells when used at concentrations ranging from 2.5 to 15 µg/ml.{46865} It induces apoptosis in A549 cells when used at concentrations ranging from 1 to 10 µg/ml, as well as increases JNK phosphorylation and sensitizes A549 cells to cisplatin (Item No. 13119) at 10 µg/ml. Dendrobine (50 mg/kg per day) reduces tumor growth in an A549 mouse xenograft model with an additive effect when used in combination with cisplatin.
Brand:CaymanSKU:26067 - 10 mgAvailable on backorder
Dendrobine is a sesquiterpenoid that has been found in D. nobile and has anticancer activity.{46864,46865} It decreases viability of A549 cells when used at concentrations ranging from 2.5 to 15 µg/ml.{46865} It induces apoptosis in A549 cells when used at concentrations ranging from 1 to 10 µg/ml, as well as increases JNK phosphorylation and sensitizes A549 cells to cisplatin (Item No. 13119) at 10 µg/ml. Dendrobine (50 mg/kg per day) reduces tumor growth in an A549 mouse xenograft model with an additive effect when used in combination with cisplatin.
Brand:CaymanSKU:26067 - 25 mgAvailable on backorder
Dendrobine is a sesquiterpenoid that has been found in D. nobile and has anticancer activity.{46864,46865} It decreases viability of A549 cells when used at concentrations ranging from 2.5 to 15 µg/ml.{46865} It induces apoptosis in A549 cells when used at concentrations ranging from 1 to 10 µg/ml, as well as increases JNK phosphorylation and sensitizes A549 cells to cisplatin (Item No. 13119) at 10 µg/ml. Dendrobine (50 mg/kg per day) reduces tumor growth in an A549 mouse xenograft model with an additive effect when used in combination with cisplatin.
Brand:CaymanSKU:26067 - 5 mgAvailable on backorder
Dendrobine is a sesquiterpenoid that has been found in D. nobile and has anticancer activity.{46864,46865} It decreases viability of A549 cells when used at concentrations ranging from 2.5 to 15 µg/ml.{46865} It induces apoptosis in A549 cells when used at concentrations ranging from 1 to 10 µg/ml, as well as increases JNK phosphorylation and sensitizes A549 cells to cisplatin (Item No. 13119) at 10 µg/ml. Dendrobine (50 mg/kg per day) reduces tumor growth in an A549 mouse xenograft model with an additive effect when used in combination with cisplatin.
Brand:CaymanSKU:26067 - 50 mgAvailable on backorder
Denudatine is an alkaloid that has been found in A. jinyangense and has antiarrhythmic activity.{58134} In vivo, denudatine (50 and 100 mg/kg) prevents aconitine-induced arrhythmias in rats and increases survival in a rat model of calcium chloride-induced arrhythmias.
Brand:CaymanSKU:30904 - 1 mgAvailable on backorder
Denudatine is an alkaloid that has been found in A. jinyangense and has antiarrhythmic activity.{58134} In vivo, denudatine (50 and 100 mg/kg) prevents aconitine-induced arrhythmias in rats and increases survival in a rat model of calcium chloride-induced arrhythmias.
Brand:CaymanSKU:30904 - 10 mgAvailable on backorder
Denudatine is an alkaloid that has been found in A. jinyangense and has antiarrhythmic activity.{58134} In vivo, denudatine (50 and 100 mg/kg) prevents aconitine-induced arrhythmias in rats and increases survival in a rat model of calcium chloride-induced arrhythmias.
Brand:CaymanSKU:30904 - 25 mgAvailable on backorder
Denudatine is an alkaloid that has been found in A. jinyangense and has antiarrhythmic activity.{58134} In vivo, denudatine (50 and 100 mg/kg) prevents aconitine-induced arrhythmias in rats and increases survival in a rat model of calcium chloride-induced arrhythmias.
Brand:CaymanSKU:30904 - 5 mgAvailable on backorder
Deoxy donepezil is a potential impurity found in bulk preparations of the acetylcholinesterase inhibitor donepezil (Item No. 13245).{46789} It is produced as a by-product during donepezil synthesis.{46790}
Brand:CaymanSKU:30045 - 1 mgAvailable on backorder
Deoxy donepezil is a potential impurity found in bulk preparations of the acetylcholinesterase inhibitor donepezil (Item No. 13245).{46789} It is produced as a by-product during donepezil synthesis.{46790}
Brand:CaymanSKU:30045 - 10 mgAvailable on backorder
Deoxy donepezil is a potential impurity found in bulk preparations of the acetylcholinesterase inhibitor donepezil (Item No. 13245).{46789} It is produced as a by-product during donepezil synthesis.{46790}
Brand:CaymanSKU:30045 - 5 mgAvailable on backorder
Deoxy donepezil is a potential impurity found in bulk preparations of the acetylcholinesterase inhibitor donepezil (Item No. 13245).{46789} It is produced as a by-product during donepezil synthesis.{46790}
Brand:CaymanSKU:30045 - 500 µgAvailable on backorder