Cayman
Showing 16651–16800 of 45550 results
-
Cyanidin 3-O-glucoside is a natural anthocyanin found in the fruits of some plants.{26793} Technically known as cyanidin 3-O-β-glucopyranoside, this polyphenolic compound scavenges superoxide anion radicals (IC50 = 69 µM) and protects neurons from oxidative stress.{26793,26794} Also, cyanidin 3-O-glucoside inhibits the ADP-ribosyl cyclase CD38 (IC50 = 6.3 µM), preventing the metabolism of NAD+ and NADP+.{26796,26795}
Brand:CaymanSKU:-Out of stock
Cyanidin 3-O-glucoside is a natural anthocyanin found in the fruits of some plants.{26793} Technically known as cyanidin 3-O-β-glucopyranoside, this polyphenolic compound scavenges superoxide anion radicals (IC50 = 69 µM) and protects neurons from oxidative stress.{26793,26794} Also, cyanidin 3-O-glucoside inhibits the ADP-ribosyl cyclase CD38 (IC50 = 6.3 µM), preventing the metabolism of NAD+ and NADP+.{26796,26795}
Brand:CaymanSKU:-Out of stock
Cyanidin 3-O-β-D-galactopyranoside is an anthocyanin flavonoid pigment that has been found in P. vera and has antioxidant properties.{49009,49010,49011} It scavenges radicals in 2,2-diphenyl-1-picrylhyrazyl (DPPH; Item No. 14805), Trolox equivalent antioxidant capacity (TEAC), superoxide anion, and hydrogen peroxide assays.{49011} Cyanidin 3-O-β-D-galactopyranoside decreases the release of lactate dehydrogenase (LDH) and the activation of caspase-3 in lymphocytes with t-butyl hydroperoxide-induced oxidative damage.
Brand:CaymanSKU:22264 -Out of stock
Cyanidin 3-O-β-D-galactopyranoside is an anthocyanin flavonoid pigment that has been found in P. vera and has antioxidant properties.{49009,49010,49011} It scavenges radicals in 2,2-diphenyl-1-picrylhyrazyl (DPPH; Item No. 14805), Trolox equivalent antioxidant capacity (TEAC), superoxide anion, and hydrogen peroxide assays.{49011} Cyanidin 3-O-β-D-galactopyranoside decreases the release of lactate dehydrogenase (LDH) and the activation of caspase-3 in lymphocytes with t-butyl hydroperoxide-induced oxidative damage.
Brand:CaymanSKU:22264 -Out of stock
Cyanidin 3-O-β-D-galactopyranoside is an anthocyanin flavonoid pigment that has been found in P. vera and has antioxidant properties.{49009,49010,49011} It scavenges radicals in 2,2-diphenyl-1-picrylhyrazyl (DPPH; Item No. 14805), Trolox equivalent antioxidant capacity (TEAC), superoxide anion, and hydrogen peroxide assays.{49011} Cyanidin 3-O-β-D-galactopyranoside decreases the release of lactate dehydrogenase (LDH) and the activation of caspase-3 in lymphocytes with t-butyl hydroperoxide-induced oxidative damage.
Brand:CaymanSKU:22264 -Out of stock
Brand:CaymanSKU:23078 - 1 gAvailable on backorder
Brand:CaymanSKU:23078 - 100 mgAvailable on backorder
Brand:CaymanSKU:23078 - 250 mgAvailable on backorder
Brand:CaymanSKU:23078 - 500 mgAvailable on backorder
Cyantraniliprole is an anthranilic diamide insecticide and an allosteric ryanodine receptor (RyR) activator.{47492} It induces calcium release from intracellular stores in Sf9 cells expressing H. virescens or D. melanogaster RyRs but not Sf9 cells that do not express RyRs. It is 300- to 500-fold selective for insect over mouse RyR1, greater than 2,000-fold selective for insect over rat RyR2, and inactive in human IMR32 cells expressing RyR2 and RyR3. It is active against insects of the order Lepidoptera, including the diamondback moth with a 50% plant protection value (PP50) of less than 0.1 ppm. It is also active against insects in the order Hemiptera, inducing mortality of the green peach aphid, cotton melon aphid, and white fly (EC50s = 1.1, 0.4, and 5.8 ppm, respectively). Formulations containing cyantraniliprole have been used as insecticides in greenhouse and nursery crops.
Brand:CaymanSKU:27309 - 10 mgAvailable on backorder
Cyantraniliprole is an anthranilic diamide insecticide and an allosteric ryanodine receptor (RyR) activator.{47492} It induces calcium release from intracellular stores in Sf9 cells expressing H. virescens or D. melanogaster RyRs but not Sf9 cells that do not express RyRs. It is 300- to 500-fold selective for insect over mouse RyR1, greater than 2,000-fold selective for insect over rat RyR2, and inactive in human IMR32 cells expressing RyR2 and RyR3. It is active against insects of the order Lepidoptera, including the diamondback moth with a 50% plant protection value (PP50) of less than 0.1 ppm. It is also active against insects in the order Hemiptera, inducing mortality of the green peach aphid, cotton melon aphid, and white fly (EC50s = 1.1, 0.4, and 5.8 ppm, respectively). Formulations containing cyantraniliprole have been used as insecticides in greenhouse and nursery crops.
Brand:CaymanSKU:27309 - 100 mgAvailable on backorder
Cyantraniliprole is an anthranilic diamide insecticide and an allosteric ryanodine receptor (RyR) activator.{47492} It induces calcium release from intracellular stores in Sf9 cells expressing H. virescens or D. melanogaster RyRs but not Sf9 cells that do not express RyRs. It is 300- to 500-fold selective for insect over mouse RyR1, greater than 2,000-fold selective for insect over rat RyR2, and inactive in human IMR32 cells expressing RyR2 and RyR3. It is active against insects of the order Lepidoptera, including the diamondback moth with a 50% plant protection value (PP50) of less than 0.1 ppm. It is also active against insects in the order Hemiptera, inducing mortality of the green peach aphid, cotton melon aphid, and white fly (EC50s = 1.1, 0.4, and 5.8 ppm, respectively). Formulations containing cyantraniliprole have been used as insecticides in greenhouse and nursery crops.
Brand:CaymanSKU:27309 - 25 mgAvailable on backorder
Cyantraniliprole is an anthranilic diamide insecticide and an allosteric ryanodine receptor (RyR) activator.{47492} It induces calcium release from intracellular stores in Sf9 cells expressing H. virescens or D. melanogaster RyRs but not Sf9 cells that do not express RyRs. It is 300- to 500-fold selective for insect over mouse RyR1, greater than 2,000-fold selective for insect over rat RyR2, and inactive in human IMR32 cells expressing RyR2 and RyR3. It is active against insects of the order Lepidoptera, including the diamondback moth with a 50% plant protection value (PP50) of less than 0.1 ppm. It is also active against insects in the order Hemiptera, inducing mortality of the green peach aphid, cotton melon aphid, and white fly (EC50s = 1.1, 0.4, and 5.8 ppm, respectively). Formulations containing cyantraniliprole have been used as insecticides in greenhouse and nursery crops.
Brand:CaymanSKU:27309 - 50 mgAvailable on backorder
CYC-116 is a potent Aurora kinase inhibitor exhibiting Ki values of 8.0 and 9.2 nM for Aurora kinases A and B, respectively.{33839} It is significantly less potent against a panel of cyclin-dependent kinases and other related kinases, with the exception of Flt-3 (Ki = 44 nM). CYC-116 exhibits broad-spectrum antiproliferative activity against a panel of human cancer cell lines with a mean IC50 value of 0.54 µM (range = 0.09 – 1.6 µM). It is orally bioavailable and inhibits the growth of human tumor xenografts in mice.
Brand:CaymanSKU:21205 -Out of stock
CYC-116 is a potent Aurora kinase inhibitor exhibiting Ki values of 8.0 and 9.2 nM for Aurora kinases A and B, respectively.{33839} It is significantly less potent against a panel of cyclin-dependent kinases and other related kinases, with the exception of Flt-3 (Ki = 44 nM). CYC-116 exhibits broad-spectrum antiproliferative activity against a panel of human cancer cell lines with a mean IC50 value of 0.54 µM (range = 0.09 – 1.6 µM). It is orally bioavailable and inhibits the growth of human tumor xenografts in mice.
Brand:CaymanSKU:21205 -Out of stock
CYC-116 is a potent Aurora kinase inhibitor exhibiting Ki values of 8.0 and 9.2 nM for Aurora kinases A and B, respectively.{33839} It is significantly less potent against a panel of cyclin-dependent kinases and other related kinases, with the exception of Flt-3 (Ki = 44 nM). CYC-116 exhibits broad-spectrum antiproliferative activity against a panel of human cancer cell lines with a mean IC50 value of 0.54 µM (range = 0.09 – 1.6 µM). It is orally bioavailable and inhibits the growth of human tumor xenografts in mice.
Brand:CaymanSKU:21205 -Out of stock
CYC-116 is a potent Aurora kinase inhibitor exhibiting Ki values of 8.0 and 9.2 nM for Aurora kinases A and B, respectively.{33839} It is significantly less potent against a panel of cyclin-dependent kinases and other related kinases, with the exception of Flt-3 (Ki = 44 nM). CYC-116 exhibits broad-spectrum antiproliferative activity against a panel of human cancer cell lines with a mean IC50 value of 0.54 µM (range = 0.09 – 1.6 µM). It is orally bioavailable and inhibits the growth of human tumor xenografts in mice.
Brand:CaymanSKU:21205 -Out of stock
Cyclic AMP (cAMP) is a central second messenger in cell signaling, propagating signals from receptors to downstream pathways. It is generated from ATP by several adenylate cyclase enzymes, which are modulated by G protein-coupled receptors.{16830} cAMP activates protein kinase A and the exchange proteins activated by cAMP (Epac1 and Epac2), which are nucleotide exchange factors for the Rap family of GTPases.{20516,23361} cAMP is degraded to AMP by cyclic nucleotide phosphodiesterases.{22521}
Brand:CaymanSKU:-Available on backorder
Cyclic AMP (cAMP) is a central second messenger in cell signaling, propagating signals from receptors to downstream pathways. It is generated from ATP by several adenylate cyclase enzymes, which are modulated by G protein-coupled receptors.{16830} cAMP activates protein kinase A and the exchange proteins activated by cAMP (Epac1 and Epac2), which are nucleotide exchange factors for the Rap family of GTPases.{20516,23361} cAMP is degraded to AMP by cyclic nucleotide phosphodiesterases.{22521}
Brand:CaymanSKU:-Available on backorder
Cyclic AMP (cAMP) is a central second messenger in cell signaling, propagating signals from receptors to downstream pathways. It is generated from ATP by several adenylate cyclase enzymes, which are modulated by G protein-coupled receptors.{16830} cAMP activates protein kinase A and the exchange proteins activated by cAMP (Epac1 and Epac2), which are nucleotide exchange factors for the Rap family of GTPases.{20516,23361} cAMP is degraded to AMP by cyclic nucleotide phosphodiesterases.{22521}
Brand:CaymanSKU:-Available on backorder
Brand:CaymanSKU:481002 - 100 dtnAvailable on backorder
Brand:CaymanSKU:481002 - 500 dtnAvailable on backorder
Cayman’s cAMP assay is a very sensitive competitive ELISA that permits cAMP measurements within the standard curve range of 0.078-10 pmol/ml, typically with a sensitivity (80% B/B0) of 0.1 pmol/ml once samples and standards have been acetylated prior to analysis. This assay has been validated with culture media, urine, tissue, and plasma samples. If you prefer to assay your samples and still achieve excellent sensitivity without the need to perform a pre-assay acetylation step we recommend using Cayman’s cAMP Select ELISA Kit. Cyclic AMP is a ubiquitous cellular second messenger that is a critical component of a signal transduction pathway linking membrane receptors and their ligands to the activation of internal cellular enzymatic activity and gene expression. cAMP is synthesized from ATP by membrane-bound adenylate cyclase. Binding of certain ligands or hormones to their specific G-protein couple receptors activates GTP binding proteins (Gs or Gi) which either stimulate or inhibit adenylate cyclase. cAMP activates or inhibits various enzymes or cascade of enzymes by promoting their phosphorylation or dephosphorylation. The cAMP signal is neutralized by hydrolysis of cAMP to AMP by phosphodiesterases. Therefore, the concentration of cAMP in a cell is a function of the ratio of the rate of synthesis from ATP by adenylate cyclase and its rate of breakdown to AMP by specific phosphodiesterases.
Brand:CaymanSKU:581001 - 480 solid wellsAvailable on backorder
Cayman’s cAMP assay is a very sensitive competitive ELISA that permits cAMP measurements within the standard curve range of 0.078-10 pmol/ml, typically with a sensitivity (80% B/B0) of 0.1 pmol/ml once samples and standards have been acetylated prior to analysis. This assay has been validated with culture media, urine, tissue, and plasma samples. If you prefer to assay your samples and still achieve excellent sensitivity without the need to perform a pre-assay acetylation step we recommend using Cayman’s cAMP Select ELISA Kit. Cyclic AMP is a ubiquitous cellular second messenger that is a critical component of a signal transduction pathway linking membrane receptors and their ligands to the activation of internal cellular enzymatic activity and gene expression. cAMP is synthesized from ATP by membrane-bound adenylate cyclase. Binding of certain ligands or hormones to their specific G-protein couple receptors activates GTP binding proteins (Gs or Gi) which either stimulate or inhibit adenylate cyclase. cAMP activates or inhibits various enzymes or cascade of enzymes by promoting their phosphorylation or dephosphorylation. The cAMP signal is neutralized by hydrolysis of cAMP to AMP by phosphodiesterases. Therefore, the concentration of cAMP in a cell is a function of the ratio of the rate of synthesis from ATP by adenylate cyclase and its rate of breakdown to AMP by specific phosphodiesterases.
Brand:CaymanSKU:581001 - 480 strip wellsAvailable on backorder
Cayman’s cAMP assay is a very sensitive competitive ELISA that permits cAMP measurements within the standard curve range of 0.078-10 pmol/ml, typically with a sensitivity (80% B/B0) of 0.1 pmol/ml once samples and standards have been acetylated prior to analysis. This assay has been validated with culture media, urine, tissue, and plasma samples. If you prefer to assay your samples and still achieve excellent sensitivity without the need to perform a pre-assay acetylation step we recommend using Cayman’s cAMP Select ELISA Kit. Cyclic AMP is a ubiquitous cellular second messenger that is a critical component of a signal transduction pathway linking membrane receptors and their ligands to the activation of internal cellular enzymatic activity and gene expression. cAMP is synthesized from ATP by membrane-bound adenylate cyclase. Binding of certain ligands or hormones to their specific G-protein couple receptors activates GTP binding proteins (Gs or Gi) which either stimulate or inhibit adenylate cyclase. cAMP activates or inhibits various enzymes or cascade of enzymes by promoting their phosphorylation or dephosphorylation. The cAMP signal is neutralized by hydrolysis of cAMP to AMP by phosphodiesterases. Therefore, the concentration of cAMP in a cell is a function of the ratio of the rate of synthesis from ATP by adenylate cyclase and its rate of breakdown to AMP by specific phosphodiesterases.
Brand:CaymanSKU:581001 - 96 solid wellsAvailable on backorder
Cayman’s cAMP assay is a very sensitive competitive ELISA that permits cAMP measurements within the standard curve range of 0.078-10 pmol/ml, typically with a sensitivity (80% B/B0) of 0.1 pmol/ml once samples and standards have been acetylated prior to analysis. This assay has been validated with culture media, urine, tissue, and plasma samples. If you prefer to assay your samples and still achieve excellent sensitivity without the need to perform a pre-assay acetylation step we recommend using Cayman’s cAMP Select ELISA Kit. Cyclic AMP is a ubiquitous cellular second messenger that is a critical component of a signal transduction pathway linking membrane receptors and their ligands to the activation of internal cellular enzymatic activity and gene expression. cAMP is synthesized from ATP by membrane-bound adenylate cyclase. Binding of certain ligands or hormones to their specific G-protein couple receptors activates GTP binding proteins (Gs or Gi) which either stimulate or inhibit adenylate cyclase. cAMP activates or inhibits various enzymes or cascade of enzymes by promoting their phosphorylation or dephosphorylation. The cAMP signal is neutralized by hydrolysis of cAMP to AMP by phosphodiesterases. Therefore, the concentration of cAMP in a cell is a function of the ratio of the rate of synthesis from ATP by adenylate cyclase and its rate of breakdown to AMP by specific phosphodiesterases.
Brand:CaymanSKU:581001 - 96 strip wellsAvailable on backorder
Cayman’s cAMP assay is a very sensitive competitive ELISA that permits cAMP measurements within the standard curve range of 0.078-10 pmol/ml, typically with a sensitivity (80% B/B0) of 0.1 pmol/ml once samples and standards have been acetylated prior to analysis. This assay has been validated with culture media, urine, tissue, and plasma samples. If you prefer to assay your samples and still achieve excellent sensitivity without the need to perform a pre-assay acetylation step we recommend using Cayman’s cAMP Select ELISA Kit. Cyclic AMP is a ubiquitous cellular second messenger that is a critical component of a signal transduction pathway linking membrane receptors and their ligands to the activation of internal cellular enzymatic activity and gene expression. cAMP is synthesized from ATP by membrane-bound adenylate cyclase. Binding of certain ligands or hormones to their specific G-protein couple receptors activates GTP binding proteins (Gs or Gi) which either stimulate or inhibit adenylate cyclase. cAMP activates or inhibits various enzymes or cascade of enzymes by promoting their phosphorylation or dephosphorylation. The cAMP signal is neutralized by hydrolysis of cAMP to AMP by phosphodiesterases. Therefore, the concentration of cAMP in a cell is a function of the ratio of the rate of synthesis from ATP by adenylate cyclase and its rate of breakdown to AMP by specific phosphodiesterases.
Brand:CaymanSKU:581002 - 480 solid wellsAvailable on backorder
Cayman’s cAMP assay is a very sensitive competitive ELISA that permits cAMP measurements within the standard curve range of 0.078-10 pmol/ml, typically with a sensitivity (80% B/B0) of 0.1 pmol/ml once samples and standards have been acetylated prior to analysis. This assay has been validated with culture media, urine, tissue, and plasma samples. If you prefer to assay your samples and still achieve excellent sensitivity without the need to perform a pre-assay acetylation step we recommend using Cayman’s cAMP Select ELISA Kit. Cyclic AMP is a ubiquitous cellular second messenger that is a critical component of a signal transduction pathway linking membrane receptors and their ligands to the activation of internal cellular enzymatic activity and gene expression. cAMP is synthesized from ATP by membrane-bound adenylate cyclase. Binding of certain ligands or hormones to their specific G-protein couple receptors activates GTP binding proteins (Gs or Gi) which either stimulate or inhibit adenylate cyclase. cAMP activates or inhibits various enzymes or cascade of enzymes by promoting their phosphorylation or dephosphorylation. The cAMP signal is neutralized by hydrolysis of cAMP to AMP by phosphodiesterases. Therefore, the concentration of cAMP in a cell is a function of the ratio of the rate of synthesis from ATP by adenylate cyclase and its rate of breakdown to AMP by specific phosphodiesterases.
Brand:CaymanSKU:581002 - 480 strip wellsAvailable on backorder
Cayman’s cAMP assay is a very sensitive competitive ELISA that permits cAMP measurements within the standard curve range of 0.078-10 pmol/ml, typically with a sensitivity (80% B/B0) of 0.1 pmol/ml once samples and standards have been acetylated prior to analysis. This assay has been validated with culture media, urine, tissue, and plasma samples. If you prefer to assay your samples and still achieve excellent sensitivity without the need to perform a pre-assay acetylation step we recommend using Cayman’s cAMP Select ELISA Kit. Cyclic AMP is a ubiquitous cellular second messenger that is a critical component of a signal transduction pathway linking membrane receptors and their ligands to the activation of internal cellular enzymatic activity and gene expression. cAMP is synthesized from ATP by membrane-bound adenylate cyclase. Binding of certain ligands or hormones to their specific G-protein couple receptors activates GTP binding proteins (Gs or Gi) which either stimulate or inhibit adenylate cyclase. cAMP activates or inhibits various enzymes or cascade of enzymes by promoting their phosphorylation or dephosphorylation. The cAMP signal is neutralized by hydrolysis of cAMP to AMP by phosphodiesterases. Therefore, the concentration of cAMP in a cell is a function of the ratio of the rate of synthesis from ATP by adenylate cyclase and its rate of breakdown to AMP by specific phosphodiesterases.
Brand:CaymanSKU:581002 - 96 solid wellsAvailable on backorder
Cayman’s cAMP assay is a very sensitive competitive ELISA that permits cAMP measurements within the standard curve range of 0.078-10 pmol/ml, typically with a sensitivity (80% B/B0) of 0.1 pmol/ml once samples and standards have been acetylated prior to analysis. This assay has been validated with culture media, urine, tissue, and plasma samples. If you prefer to assay your samples and still achieve excellent sensitivity without the need to perform a pre-assay acetylation step we recommend using Cayman’s cAMP Select ELISA Kit. Cyclic AMP is a ubiquitous cellular second messenger that is a critical component of a signal transduction pathway linking membrane receptors and their ligands to the activation of internal cellular enzymatic activity and gene expression. cAMP is synthesized from ATP by membrane-bound adenylate cyclase. Binding of certain ligands or hormones to their specific G-protein couple receptors activates GTP binding proteins (Gs or Gi) which either stimulate or inhibit adenylate cyclase. cAMP activates or inhibits various enzymes or cascade of enzymes by promoting their phosphorylation or dephosphorylation. The cAMP signal is neutralized by hydrolysis of cAMP to AMP by phosphodiesterases. Therefore, the concentration of cAMP in a cell is a function of the ratio of the rate of synthesis from ATP by adenylate cyclase and its rate of breakdown to AMP by specific phosphodiesterases.
Brand:CaymanSKU:581002 - 96 strip wellsAvailable on backorder
Brand:CaymanSKU:481004 - 1 eaAvailable on backorder
Brand:CaymanSKU:401042 - 100 dtnAvailable on backorder
Brand:CaymanSKU:401042 - 500 dtnAvailable on backorder
Cayman’s cAMP Select assay is a competitive ELISA that permits cAMP measurements within the standard curve range of 0.09-200 pmol/ml and a sensitivity (80% B/B0) of approximately 0.6 pmol/ml. Acetylation of samples is not required in this highly sensitive assay where culture media, urine, tissue, and plasma samples have been validated. Cyclic AMP is a ubiquitous cellular second messenger that is a critical component of a signal transduction pathway linking membrane receptors and their ligands to the activation of internal cellular enzymatic activity and gene expression. cAMP is synthesized from ATP by membrane-bound adenylate cyclase. Binding of certain ligands or hormones to their specific G-protein couple receptors activates GTP binding proteins (Gs or Gi) which either stimulate or inhibit adenylate cyclase. cAMP activates or inhibits various enzymes or cascade of enzymes by promoting their phosphorylation or dephosphorylation. The cAMP signal is neutralized by hydrolysis of cAMP to AMP by phosphodiesterases. Therefore, the concentration of cAMP in a cell is a function of the ratio of the rate of synthesis from ATP by adenylate cyclase and its rate of breakdown to AMP by specific phosphodiesterases.
Brand:CaymanSKU:501040 - 480 solid wellsAvailable on backorder
Cayman’s cAMP Select assay is a competitive ELISA that permits cAMP measurements within the standard curve range of 0.09-200 pmol/ml and a sensitivity (80% B/B0) of approximately 0.6 pmol/ml. Acetylation of samples is not required in this highly sensitive assay where culture media, urine, tissue, and plasma samples have been validated. Cyclic AMP is a ubiquitous cellular second messenger that is a critical component of a signal transduction pathway linking membrane receptors and their ligands to the activation of internal cellular enzymatic activity and gene expression. cAMP is synthesized from ATP by membrane-bound adenylate cyclase. Binding of certain ligands or hormones to their specific G-protein couple receptors activates GTP binding proteins (Gs or Gi) which either stimulate or inhibit adenylate cyclase. cAMP activates or inhibits various enzymes or cascade of enzymes by promoting their phosphorylation or dephosphorylation. The cAMP signal is neutralized by hydrolysis of cAMP to AMP by phosphodiesterases. Therefore, the concentration of cAMP in a cell is a function of the ratio of the rate of synthesis from ATP by adenylate cyclase and its rate of breakdown to AMP by specific phosphodiesterases.
Brand:CaymanSKU:501040 - 480 strip wellsAvailable on backorder
Cayman’s cAMP Select assay is a competitive ELISA that permits cAMP measurements within the standard curve range of 0.09-200 pmol/ml and a sensitivity (80% B/B0) of approximately 0.6 pmol/ml. Acetylation of samples is not required in this highly sensitive assay where culture media, urine, tissue, and plasma samples have been validated. Cyclic AMP is a ubiquitous cellular second messenger that is a critical component of a signal transduction pathway linking membrane receptors and their ligands to the activation of internal cellular enzymatic activity and gene expression. cAMP is synthesized from ATP by membrane-bound adenylate cyclase. Binding of certain ligands or hormones to their specific G-protein couple receptors activates GTP binding proteins (Gs or Gi) which either stimulate or inhibit adenylate cyclase. cAMP activates or inhibits various enzymes or cascade of enzymes by promoting their phosphorylation or dephosphorylation. The cAMP signal is neutralized by hydrolysis of cAMP to AMP by phosphodiesterases. Therefore, the concentration of cAMP in a cell is a function of the ratio of the rate of synthesis from ATP by adenylate cyclase and its rate of breakdown to AMP by specific phosphodiesterases.
Brand:CaymanSKU:501040 - 96 solid wellsAvailable on backorder
Cayman’s cAMP Select assay is a competitive ELISA that permits cAMP measurements within the standard curve range of 0.09-200 pmol/ml and a sensitivity (80% B/B0) of approximately 0.6 pmol/ml. Acetylation of samples is not required in this highly sensitive assay where culture media, urine, tissue, and plasma samples have been validated. Cyclic AMP is a ubiquitous cellular second messenger that is a critical component of a signal transduction pathway linking membrane receptors and their ligands to the activation of internal cellular enzymatic activity and gene expression. cAMP is synthesized from ATP by membrane-bound adenylate cyclase. Binding of certain ligands or hormones to their specific G-protein couple receptors activates GTP binding proteins (Gs or Gi) which either stimulate or inhibit adenylate cyclase. cAMP activates or inhibits various enzymes or cascade of enzymes by promoting their phosphorylation or dephosphorylation. The cAMP signal is neutralized by hydrolysis of cAMP to AMP by phosphodiesterases. Therefore, the concentration of cAMP in a cell is a function of the ratio of the rate of synthesis from ATP by adenylate cyclase and its rate of breakdown to AMP by specific phosphodiesterases.
Brand:CaymanSKU:501040 - 96 strip wellsAvailable on backorder
Brand:CaymanSKU:401044 - 2000 pmolAvailable on backorder
Cayman’s Cyclic di-AMP ELISA Kit is a competitive assay that can be used for quantification of cyclic di-AMP in bacterial cell lysates. The assay has a range of 15.6-2,000 pg/ml with a midpoint of approximately 180 pg/ml (50% B/B0) and a sensitivity (80% B/B0) of approximately 66 pg/ml. Powered by BIOLOG Life Science Institute.
Brand:CaymanSKU:501960 - 96 solid wellsAvailable on backorder
Cayman’s Cyclic di-AMP ELISA Kit is a competitive assay that can be used for quantification of cyclic di-AMP in bacterial cell lysates. The assay has a range of 15.6-2,000 pg/ml with a midpoint of approximately 180 pg/ml (50% B/B0) and a sensitivity (80% B/B0) of approximately 66 pg/ml. Powered by BIOLOG Life Science Institute.
Brand:CaymanSKU:501960 - 96 strip wellsAvailable on backorder
Cyclic di-AMP ELISA Standard has been tested and formulated to work exclusively with Cayman’s Cyclic di-AMP ELISA Kit (Item No. 501960). Please visit Cyclic di-AMP ELISA Kit (Item No. 501960) for the kit protocol, procedures, and product handling.
Brand:CaymanSKU:401964 - 15 ngAvailable on backorder
Cyclic di-GMP is a second messenger in bacteria involved in diverse prokaryotic processes, including biofilm formation, motility, virulence, and cell cycling.{28201,28203} In eukaryotic cells, cyclic di-GMP is detected by and binds to the transmembrane protein stimulator of interferon genes (STING; Kd = 1.21 µM), leading to activation of the innate immune system.{28202,29220} It has been used at a preset molar ratio with STING dimers in binding assays to determine the binding constants of particularly tight binding partners, such as 2’3’-cGAMP. Cyclic di-GMP induces IFN-β mRNA expression in vitro (EC50 = 537.8 nM) but less potently than 2’3’-cGAMP (Item No. 19887), 3’2’-cGAMP, 3’3’-cGAMP (Item No. 17966), and 2’2’-cGAMP (Item No. 22419).
Brand:CaymanSKU:-Out of stock
Cyclic di-GMP is a second messenger in bacteria involved in diverse prokaryotic processes, including biofilm formation, motility, virulence, and cell cycling.{28201,28203} In eukaryotic cells, cyclic di-GMP is detected by and binds to the transmembrane protein stimulator of interferon genes (STING; Kd = 1.21 µM), leading to activation of the innate immune system.{28202,29220} It has been used at a preset molar ratio with STING dimers in binding assays to determine the binding constants of particularly tight binding partners, such as 2’3’-cGAMP. Cyclic di-GMP induces IFN-β mRNA expression in vitro (EC50 = 537.8 nM) but less potently than 2’3’-cGAMP (Item No. 19887), 3’2’-cGAMP, 3’3’-cGAMP (Item No. 17966), and 2’2’-cGAMP (Item No. 22419).
Brand:CaymanSKU:-Out of stock
Cayman’s Cyclic di-GMP ELISA Kit is a competitive assay that can be used for quantification of cyclic di-GMP in bacterial cell lysates. The assay has a range of 4.6-10,000 pg/ml with a midpoint of approximately 250 pg/ml (50% B/B0) and a sensitivity (80% B/B0) of approximately 38 pg/ml. Powered by BIOLOG Life Science Institute.
Brand:CaymanSKU:501780 - 96 solid wellsAvailable on backorder
Cayman’s Cyclic di-GMP ELISA Kit is a competitive assay that can be used for quantification of cyclic di-GMP in bacterial cell lysates. The assay has a range of 4.6-10,000 pg/ml with a midpoint of approximately 250 pg/ml (50% B/B0) and a sensitivity (80% B/B0) of approximately 38 pg/ml. Powered by BIOLOG Life Science Institute.
Brand:CaymanSKU:501780 - 96 strip wellsAvailable on backorder
Cyclic di-GMP ELISA Monoclonal Antibody has been tested and formulated to work exclusively with Cayman’s Cyclic di-GMP ELISA Kit (Item No. 501780). Please visit Cyclic di-GMP ELISA Kit (Item No. 501780) for the kit protocol, procedures, and product handling.
Brand:CaymanSKU:401782 - 100 dtnAvailable on backorder
Brand:CaymanSKU:401784 - 100 ngAvailable on backorder
Guanosine 3′,5′-cyclic monophosphate (cyclic GMP or cGMP) is a second messenger that is biosynthesized from GTP by guanylate cyclases. Activators of guanylate cyclases include nitric oxide and natriuretic peptides.{30357} cGMP activates protein kinase G (PKG) and modulates ion channel conductance, with signaling affecting diverse processes including smooth muscle relaxation and proliferation, phototransduction, and energy homeostasis.{30357,30360,30359,30358} The degradation of cGMP to GMP is mediated by specific and non-specific phosphodiesterases.{22523,10616}
Brand:CaymanSKU:-Available on backorder
Guanosine 3′,5′-cyclic monophosphate (cyclic GMP or cGMP) is a second messenger that is biosynthesized from GTP by guanylate cyclases. Activators of guanylate cyclases include nitric oxide and natriuretic peptides.{30357} cGMP activates protein kinase G (PKG) and modulates ion channel conductance, with signaling affecting diverse processes including smooth muscle relaxation and proliferation, phototransduction, and energy homeostasis.{30357,30360,30359,30358} The degradation of cGMP to GMP is mediated by specific and non-specific phosphodiesterases.{22523,10616}
Brand:CaymanSKU:-Available on backorder
Brand:CaymanSKU:481022 - 100 dtnAvailable on backorder
Brand:CaymanSKU:481022 - 500 dtnAvailable on backorder
The Cayman Chemical cGMP Assay is a competitive ELISA that can be used for quantification of cGMP directly obtained from cell lysates, tissue homogenates, plasma, or urine. The assay has a range from 0.23-30 pmol/ml and a sensitivity (80% B/B0) of approximately 1 pmol/ml. Since the antibody used in this assay was prepared against a cGMP-carrier protein conjugate, antibody binding is increased if an acetyl group is present on the 2′ hydroxyl group of the cGMP. The optional acetylation procedure for both samples and standards increases the sensitivity of the assay approximately 10 fold. A protocol for acetylating both the standards and samples prior to performing the assay is provided. Basal levels of cGMP in cell lysates can often be measured without acetylation, but results will depend on the type and number of cells being utilized. Platelets produce approximately 1.5-2.5 pmol cGMP/109 platelets under basal conditions.{5912,668,4218} Cells such as NG108-15 cells and monocytes produce considerably more cGMP than platelets (approximately 0.1-1 pmol/106 cells).{3743,1825}
Brand:CaymanSKU:581021 - 480 solid wellsAvailable on backorder
The Cayman Chemical cGMP Assay is a competitive ELISA that can be used for quantification of cGMP directly obtained from cell lysates, tissue homogenates, plasma, or urine. The assay has a range from 0.23-30 pmol/ml and a sensitivity (80% B/B0) of approximately 1 pmol/ml. Since the antibody used in this assay was prepared against a cGMP-carrier protein conjugate, antibody binding is increased if an acetyl group is present on the 2′ hydroxyl group of the cGMP. The optional acetylation procedure for both samples and standards increases the sensitivity of the assay approximately 10 fold. A protocol for acetylating both the standards and samples prior to performing the assay is provided. Basal levels of cGMP in cell lysates can often be measured without acetylation, but results will depend on the type and number of cells being utilized. Platelets produce approximately 1.5-2.5 pmol cGMP/109 platelets under basal conditions.{5912,668,4218} Cells such as NG108-15 cells and monocytes produce considerably more cGMP than platelets (approximately 0.1-1 pmol/106 cells).{3743,1825}
Brand:CaymanSKU:581021 - 480 strip wellsAvailable on backorder
The Cayman Chemical cGMP Assay is a competitive ELISA that can be used for quantification of cGMP directly obtained from cell lysates, tissue homogenates, plasma, or urine. The assay has a range from 0.23-30 pmol/ml and a sensitivity (80% B/B0) of approximately 1 pmol/ml. Since the antibody used in this assay was prepared against a cGMP-carrier protein conjugate, antibody binding is increased if an acetyl group is present on the 2′ hydroxyl group of the cGMP. The optional acetylation procedure for both samples and standards increases the sensitivity of the assay approximately 10 fold. A protocol for acetylating both the standards and samples prior to performing the assay is provided. Basal levels of cGMP in cell lysates can often be measured without acetylation, but results will depend on the type and number of cells being utilized. Platelets produce approximately 1.5-2.5 pmol cGMP/109 platelets under basal conditions.{5912,668,4218} Cells such as NG108-15 cells and monocytes produce considerably more cGMP than platelets (approximately 0.1-1 pmol/106 cells).{3743,1825}
Brand:CaymanSKU:581021 - 96 solid wellsAvailable on backorder
The Cayman Chemical cGMP Assay is a competitive ELISA that can be used for quantification of cGMP directly obtained from cell lysates, tissue homogenates, plasma, or urine. The assay has a range from 0.23-30 pmol/ml and a sensitivity (80% B/B0) of approximately 1 pmol/ml. Since the antibody used in this assay was prepared against a cGMP-carrier protein conjugate, antibody binding is increased if an acetyl group is present on the 2′ hydroxyl group of the cGMP. The optional acetylation procedure for both samples and standards increases the sensitivity of the assay approximately 10 fold. A protocol for acetylating both the standards and samples prior to performing the assay is provided. Basal levels of cGMP in cell lysates can often be measured without acetylation, but results will depend on the type and number of cells being utilized. Platelets produce approximately 1.5-2.5 pmol cGMP/109 platelets under basal conditions.{5912,668,4218} Cells such as NG108-15 cells and monocytes produce considerably more cGMP than platelets (approximately 0.1-1 pmol/106 cells).{3743,1825}
Brand:CaymanSKU:581021 - 96 strip wellsAvailable on backorder
cGMP is a key intracellular second messenger molecule which transduces cellular signaling events in response to a variety of hormones, autacoids and drugs. cGMP is synthesized from GTP by both membrane-bound and soluble guanlyate cyclase enzymes. The relative abundance of cGMP within a given cell can serve as a marker for activation by agonists acting through particulate guanylate cyclase at the cell surface, or intracellular activation of soluble guanylate cyclase by nitric oxide. Cayman’s cGMP Assay is a competitive ELISA that can be used for quantification of cGMP directly obtained from cell lysates, tissue homogenates, plasma or urine. The assay has a range from 0.23-30 pmol/ml and a sensitivity (80% B/B0) of approximately 1 pmol/ml. Since the antibody used in this assay was prepared against a cGMP-carrier protein conjugate, antibody binding is increased if an acetyl group is present on the 2’ hydroxyl group of the cGMP. The optional acetylation procedure for both samples and standards increases the sensitivity of the assay approximately ten-fold.
Brand:CaymanSKU:581022 - 480 solid wellsAvailable on backorder
cGMP is a key intracellular second messenger molecule which transduces cellular signaling events in response to a variety of hormones, autacoids and drugs. cGMP is synthesized from GTP by both membrane-bound and soluble guanlyate cyclase enzymes. The relative abundance of cGMP within a given cell can serve as a marker for activation by agonists acting through particulate guanylate cyclase at the cell surface, or intracellular activation of soluble guanylate cyclase by nitric oxide. Cayman’s cGMP Assay is a competitive ELISA that can be used for quantification of cGMP directly obtained from cell lysates, tissue homogenates, plasma or urine. The assay has a range from 0.23-30 pmol/ml and a sensitivity (80% B/B0) of approximately 1 pmol/ml. Since the antibody used in this assay was prepared against a cGMP-carrier protein conjugate, antibody binding is increased if an acetyl group is present on the 2’ hydroxyl group of the cGMP. The optional acetylation procedure for both samples and standards increases the sensitivity of the assay approximately ten-fold.
Brand:CaymanSKU:581022 - 480 strip wellsAvailable on backorder
cGMP is a key intracellular second messenger molecule which transduces cellular signaling events in response to a variety of hormones, autacoids and drugs. cGMP is synthesized from GTP by both membrane-bound and soluble guanlyate cyclase enzymes. The relative abundance of cGMP within a given cell can serve as a marker for activation by agonists acting through particulate guanylate cyclase at the cell surface, or intracellular activation of soluble guanylate cyclase by nitric oxide. Cayman’s cGMP Assay is a competitive ELISA that can be used for quantification of cGMP directly obtained from cell lysates, tissue homogenates, plasma or urine. The assay has a range from 0.23-30 pmol/ml and a sensitivity (80% B/B0) of approximately 1 pmol/ml. Since the antibody used in this assay was prepared against a cGMP-carrier protein conjugate, antibody binding is increased if an acetyl group is present on the 2’ hydroxyl group of the cGMP. The optional acetylation procedure for both samples and standards increases the sensitivity of the assay approximately ten-fold.
Brand:CaymanSKU:581022 - 96 solid wellsAvailable on backorder
cGMP is a key intracellular second messenger molecule which transduces cellular signaling events in response to a variety of hormones, autacoids and drugs. cGMP is synthesized from GTP by both membrane-bound and soluble guanlyate cyclase enzymes. The relative abundance of cGMP within a given cell can serve as a marker for activation by agonists acting through particulate guanylate cyclase at the cell surface, or intracellular activation of soluble guanylate cyclase by nitric oxide. Cayman’s cGMP Assay is a competitive ELISA that can be used for quantification of cGMP directly obtained from cell lysates, tissue homogenates, plasma or urine. The assay has a range from 0.23-30 pmol/ml and a sensitivity (80% B/B0) of approximately 1 pmol/ml. Since the antibody used in this assay was prepared against a cGMP-carrier protein conjugate, antibody binding is increased if an acetyl group is present on the 2’ hydroxyl group of the cGMP. The optional acetylation procedure for both samples and standards increases the sensitivity of the assay approximately ten-fold.
Brand:CaymanSKU:581022 - 96 strip wellsAvailable on backorder
Brand:CaymanSKU:481024 - 1 eaAvailable on backorder
Pifithrin-α (PFT-α; Item No. 13326) is a reversible inhibitor of p53-dependent transcription and apoptosis.{17259} Cyclic PFT-α, also known as PFT-β, is a stable analog of PFT-α, formed by the condensation of pifithrin-α in solution.{23585} It inhibits the growth of the cancer cell lines IGROV-1, A2780, and HCT116 (IC50 = 23, 77, and 103 μM, respectively).{23585,23586} At doses lower than those that inhibit growth, cyclic PFT-α induces autophagy in HCT116 cells and sensitizes IGROV-1 and H460 cells to anti-microtubule agents.{23579,23580} In addition, 10 μM cyclic PFT-α blocks p53-dependent protection from DNA damage, induced by hydrogen peroxide or ultraviolet radiation, in melanocytes.{23581}
Brand:CaymanSKU:- Pifithrin-α (PFT-α; Item No. 13326) is a reversible inhibitor of p53-dependent transcription and apoptosis.{17259} Cyclic PFT-α, also known as PFT-β, is a stable analog of PFT-α, formed by the condensation of pifithrin-α in solution.{23585} It inhibits the growth of the cancer cell lines IGROV-1, A2780, and HCT116 (IC50 = 23, 77, and 103 μM, respectively).{23585,23586} At doses lower than those that inhibit growth, cyclic PFT-α induces autophagy in HCT116 cells and sensitizes IGROV-1 and H460 cells to anti-microtubule agents.{23579,23580} In addition, 10 μM cyclic PFT-α blocks p53-dependent protection from DNA damage, induced by hydrogen peroxide or ultraviolet radiation, in melanocytes.{23581}
Brand:CaymanSKU:- Pifithrin-α (PFT-α; Item No. 13326) is a reversible inhibitor of p53-dependent transcription and apoptosis.{17259} Cyclic PFT-α, also known as PFT-β, is a stable analog of PFT-α, formed by the condensation of pifithrin-α in solution.{23585} It inhibits the growth of the cancer cell lines IGROV-1, A2780, and HCT116 (IC50 = 23, 77, and 103 μM, respectively).{23585,23586} At doses lower than those that inhibit growth, cyclic PFT-α induces autophagy in HCT116 cells and sensitizes IGROV-1 and H460 cells to anti-microtubule agents.{23579,23580} In addition, 10 μM cyclic PFT-α blocks p53-dependent protection from DNA damage, induced by hydrogen peroxide or ultraviolet radiation, in melanocytes.{23581}
Brand:CaymanSKU:- Pifithrin-α (PFT-α; Item No. 13326) is a reversible inhibitor of p53-dependent transcription and apoptosis.{17259} Cyclic PFT-α, also known as PFT-β, is a stable analog of PFT-α, formed by the condensation of pifithrin-α in solution.{23585} It inhibits the growth of the cancer cell lines IGROV-1, A2780, and HCT116 (IC50 = 23, 77, and 103 μM, respectively).{23585,23586} At doses lower than those that inhibit growth, cyclic PFT-α induces autophagy in HCT116 cells and sensitizes IGROV-1 and H460 cells to anti-microtubule agents.{23579,23580} In addition, 10 μM cyclic PFT-α blocks p53-dependent protection from DNA damage, induced by hydrogen peroxide or ultraviolet radiation, in melanocytes.{23581}
Brand:CaymanSKU:-
Immunogen: Peptide corresponding to cyclin D1 • Host: Rabbit • Species Reactivity: (+) Human • Applications: IHC, WB • MW = ~34 kDa
Brand:CaymanSKU:32195- 100 µlAvailable on backorder
Immunogen: Peptide corresponding to cyclin D1 • Host: Rabbit • Species Reactivity: (+) Human • Applications: IHC, WB • MW = ~34 kDa
Brand:CaymanSKU:32195- 100 µl Cyclin D1 is a regulatory protein that controls cell proliferation by promoting cell cycle progression from G1 to S phase.{59540} It is induced during the G1 phase following stimulation with mitogens, including growth factors, hormones, and cytokines, and heterodimerizes with cyclin-dependent kinase 4 (Cdk4) or Cdk6 in the cytoplasm.{59541,59542} The cyclin D1/Cdk4/6 complex translocates to the nucleus and phosphorylates retinoblastoma protein (Rb), permitting expression of E2F transcription factors, which drive S phase entry and progression.{59542,59543,59540} During the G1/S phase transition, cyclin D1 is phosphorylated by glycogen synthase kinase 3β (GSK3β) and exported to the cytoplasm where it is ubiquitinated and degraded. CCND1, the gene encoding cyclin D1, is overexpressed in a variety of human cancers, including mantle cell lymphoma, pancreatic cancer, and breast cancer, and tumor cyclin D1 levels are increased in patients with colorectal cancer and associated with decreased overall survival.{59544,59545} Cayman’s Cyclin D1 Rabbit Monoclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications. The antibody recognizes cyclin D1 at approximately 34 kDa from human samples.
Brand:CaymanSKU:32195 - 100 µlAvailable on backorder
Cyclizine is a histamine H1 receptor antagonist.{52784,52785,46616} It binds selectively to histamine H1 receptors (Kd = 5 nM) over H2 and H3 receptors (Kds = 1,600 and >580 nM, respectively).{46616} Cyclizine inhibits anti-IgE-induced histamine release from isolated human lung fragments with an IC50 value of 5.42 µM but induces histamine release with a 50% release concentration (RC50) of 10.81 µM.{52786} It reduces LPS-induced nitrite accumulation and protein levels of induced nitric oxide synthase (iNOS) in RAW 264.7 cells when used at a concentration of 100 nM.{52785} Cyclizine (10 and 20 mg/kg) reduces immobility in the forced swim test in rats.{52787}
Brand:CaymanSKU:31190 - 1 gAvailable on backorder
Cyclizine is a histamine H1 receptor antagonist.{52784,52785,46616} It binds selectively to histamine H1 receptors (Kd = 5 nM) over H2 and H3 receptors (Kds = 1,600 and >580 nM, respectively).{46616} Cyclizine inhibits anti-IgE-induced histamine release from isolated human lung fragments with an IC50 value of 5.42 µM but induces histamine release with a 50% release concentration (RC50) of 10.81 µM.{52786} It reduces LPS-induced nitrite accumulation and protein levels of induced nitric oxide synthase (iNOS) in RAW 264.7 cells when used at a concentration of 100 nM.{52785} Cyclizine (10 and 20 mg/kg) reduces immobility in the forced swim test in rats.{52787}
Brand:CaymanSKU:31190 - 250 mgAvailable on backorder
Cyclizine is a histamine H1 receptor antagonist.{52784,52785,46616} It binds selectively to histamine H1 receptors (Kd = 5 nM) over H2 and H3 receptors (Kds = 1,600 and >580 nM, respectively).{46616} Cyclizine inhibits anti-IgE-induced histamine release from isolated human lung fragments with an IC50 value of 5.42 µM but induces histamine release with a 50% release concentration (RC50) of 10.81 µM.{52786} It reduces LPS-induced nitrite accumulation and protein levels of induced nitric oxide synthase (iNOS) in RAW 264.7 cells when used at a concentration of 100 nM.{52785} Cyclizine (10 and 20 mg/kg) reduces immobility in the forced swim test in rats.{52787}
Brand:CaymanSKU:31190 - 5 gAvailable on backorder
Cyclizine is a histamine H1 receptor antagonist.{52784,52785,46616} It binds selectively to histamine H1 receptors (Kd = 5 nM) over H2 and H3 receptors (Kds = 1,600 and >580 nM, respectively).{46616} Cyclizine inhibits anti-IgE-induced histamine release from isolated human lung fragments with an IC50 value of 5.42 µM but induces histamine release with a 50% release concentration (RC50) of 10.81 µM.{52786} It reduces LPS-induced nitrite accumulation and protein levels of induced nitric oxide synthase (iNOS) in RAW 264.7 cells when used at a concentration of 100 nM.{52785} Cyclizine (10 and 20 mg/kg) reduces immobility in the forced swim test in rats.{52787}
Brand:CaymanSKU:31190 - 500 mgAvailable on backorder
Cyclo(D-Ala-L-Pro) is a diketopiperazine fungal metabolite originally isolated from P. terreste.{39711}
Brand:CaymanSKU:24940 - 25 mgAvailable on backorder
Cyclo(D-Ala-L-Pro) is a diketopiperazine fungal metabolite originally isolated from P. terreste.{39711}
Brand:CaymanSKU:24940 - 5 mgAvailable on backorder
Cyclo(L-His-L-Pro) is an endogenous cyclic neuropeptide and a metabolite of thyrotropin-releasing hormone (TRH).{57272} It is formed in the hypothalamus via the hydrolytic removal of pyroglutamic acid from TRH followed by non-enzymatic cyclization but is also synthesized de novo.{57273} It is ubiquitously expressed in the CNS, but is also found in the gastrointestinal tract and blood. Cyclo(L-His-L-Pro) (50 µM) reduces LPS-induced production of reactive oxygen species (ROS) and nitric oxide (NO), as well translocation of NF-κB in BV-2 microglia. Levels of cyclo(L-His-L-Pro) are increased in rat brain after six weeks of continuous ethanol consumption and cyclo(L-His-L-Pro) reduces ethanol-induced sleep time in rats when administered at a dose of 1 µmol/kg.{57272,57274} Cyclo(L-His-L-Pro) induces analgesia in the hot-plate test and reduces acetic acid-induced writhing in mice, effects that can be partially reversed by the opioid antagonist naloxone.{57272}
Brand:CaymanSKU:31172 - 10 mgAvailable on backorder
Cyclo(L-His-L-Pro) is an endogenous cyclic neuropeptide and a metabolite of thyrotropin-releasing hormone (TRH).{57272} It is formed in the hypothalamus via the hydrolytic removal of pyroglutamic acid from TRH followed by non-enzymatic cyclization but is also synthesized de novo.{57273} It is ubiquitously expressed in the CNS, but is also found in the gastrointestinal tract and blood. Cyclo(L-His-L-Pro) (50 µM) reduces LPS-induced production of reactive oxygen species (ROS) and nitric oxide (NO), as well translocation of NF-κB in BV-2 microglia. Levels of cyclo(L-His-L-Pro) are increased in rat brain after six weeks of continuous ethanol consumption and cyclo(L-His-L-Pro) reduces ethanol-induced sleep time in rats when administered at a dose of 1 µmol/kg.{57272,57274} Cyclo(L-His-L-Pro) induces analgesia in the hot-plate test and reduces acetic acid-induced writhing in mice, effects that can be partially reversed by the opioid antagonist naloxone.{57272}
Brand:CaymanSKU:31172 - 100 mgAvailable on backorder
Cyclo(L-His-L-Pro) is an endogenous cyclic neuropeptide and a metabolite of thyrotropin-releasing hormone (TRH).{57272} It is formed in the hypothalamus via the hydrolytic removal of pyroglutamic acid from TRH followed by non-enzymatic cyclization but is also synthesized de novo.{57273} It is ubiquitously expressed in the CNS, but is also found in the gastrointestinal tract and blood. Cyclo(L-His-L-Pro) (50 µM) reduces LPS-induced production of reactive oxygen species (ROS) and nitric oxide (NO), as well translocation of NF-κB in BV-2 microglia. Levels of cyclo(L-His-L-Pro) are increased in rat brain after six weeks of continuous ethanol consumption and cyclo(L-His-L-Pro) reduces ethanol-induced sleep time in rats when administered at a dose of 1 µmol/kg.{57272,57274} Cyclo(L-His-L-Pro) induces analgesia in the hot-plate test and reduces acetic acid-induced writhing in mice, effects that can be partially reversed by the opioid antagonist naloxone.{57272}
Brand:CaymanSKU:31172 - 25 mgAvailable on backorder
Cyclo(L-His-L-Pro) is an endogenous cyclic neuropeptide and a metabolite of thyrotropin-releasing hormone (TRH).{57272} It is formed in the hypothalamus via the hydrolytic removal of pyroglutamic acid from TRH followed by non-enzymatic cyclization but is also synthesized de novo.{57273} It is ubiquitously expressed in the CNS, but is also found in the gastrointestinal tract and blood. Cyclo(L-His-L-Pro) (50 µM) reduces LPS-induced production of reactive oxygen species (ROS) and nitric oxide (NO), as well translocation of NF-κB in BV-2 microglia. Levels of cyclo(L-His-L-Pro) are increased in rat brain after six weeks of continuous ethanol consumption and cyclo(L-His-L-Pro) reduces ethanol-induced sleep time in rats when administered at a dose of 1 µmol/kg.{57272,57274} Cyclo(L-His-L-Pro) induces analgesia in the hot-plate test and reduces acetic acid-induced writhing in mice, effects that can be partially reversed by the opioid antagonist naloxone.{57272}
Brand:CaymanSKU:31172 - 50 mgAvailable on backorder
Cyclo(L-Leu-L-Pro) is a diketopiperazine metabolite that has been isolated from various bacterial and fungal species including Streptomyces.{39703} It is active against twelve strains of vancomycin-resistant enterococci (VRE) with MIC values of 12.5 µg/ml for E. faecalis strains K-99-34, K-00-184, and K-00-221.{39703} It also inhibits growth of K562, HL-60, and U937 leukemia cells in a concentration-dependent manner when used at concentrations of 1-500 µg/ml. Cyclo(L-Leu-L-Pro) also has antifouling activity, inhibiting attachment of B. amphitrite larva with an EC50 value of 0.15 mM.{39704}
Brand:CaymanSKU:24941 - 25 mgAvailable on backorder
Cyclo(L-Leu-L-Pro) is a diketopiperazine metabolite that has been isolated from various bacterial and fungal species including Streptomyces.{39703} It is active against twelve strains of vancomycin-resistant enterococci (VRE) with MIC values of 12.5 µg/ml for E. faecalis strains K-99-34, K-00-184, and K-00-221.{39703} It also inhibits growth of K562, HL-60, and U937 leukemia cells in a concentration-dependent manner when used at concentrations of 1-500 µg/ml. Cyclo(L-Leu-L-Pro) also has antifouling activity, inhibiting attachment of B. amphitrite larva with an EC50 value of 0.15 mM.{39704}
Brand:CaymanSKU:24941 - 5 mgAvailable on backorder
Cyclo(L-Leu-L-Trp) is a diketopiperazine metabolite originally isolated from Penicillium.{39706} It is active against various bacteria (MICs = 125-1000 µg/ml) and fungi (MICs = 8-64 µg/ml), and it inhibits the production rate of hydroxy radicals in an electron spin resonance (ESR) spectroscopy-based assay (IC50 = 1.8 µM).{39707,39708} Cyclo(L-Leu-L-Trp) is a bitter tastant that can rapidly permeate rat taste cell membranes ex vivo when used at a concentration of 1 mM.{39709} It also acts as a melatonin receptor agonist in X. laevis melanophores, inhibiting cAMP accumulation when used at a concentration of 20 µM, an effect that is blocked by the melatonin receptor antagonist luzindole (Item No. 15998).{39710}
Brand:CaymanSKU:24942 - 25 mgAvailable on backorder
Cyclo(L-Leu-L-Trp) is a diketopiperazine metabolite originally isolated from Penicillium.{39706} It is active against various bacteria (MICs = 125-1000 µg/ml) and fungi (MICs = 8-64 µg/ml), and it inhibits the production rate of hydroxy radicals in an electron spin resonance (ESR) spectroscopy-based assay (IC50 = 1.8 µM).{39707,39708} Cyclo(L-Leu-L-Trp) is a bitter tastant that can rapidly permeate rat taste cell membranes ex vivo when used at a concentration of 1 mM.{39709} It also acts as a melatonin receptor agonist in X. laevis melanophores, inhibiting cAMP accumulation when used at a concentration of 20 µM, an effect that is blocked by the melatonin receptor antagonist luzindole (Item No. 15998).{39710}
Brand:CaymanSKU:24942 - 5 mgAvailable on backorder