Cayman
Showing 16501–16650 of 45550 results
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Cu-ATSM is a copper-containing compound with diverse biological activities.{49720,30772,30772} It inhibits ferroptotic cell death induced by RSL3, erastin (Item No. 17754), or iron(II) (EC50s = 134, 169, and 171 nM, respectively), as well as RSL3-, erastin-, or iron-induced lipid peroxidation in N27 rat mesencephalic cells when used at a concentration of 1 µM.{49720} Cu-ATSM (30 mg/kg per day) increases mutant superoxide dismutase (SOD1G37R) protein levels, metalation, and activity in the spinal cord in the SOD1G37R transgenic mouse model of amyotrophic lateral sclerosis (ALS).{30772} It also increases the number of α-motor neurons and reduces oxidatively modified proteins in the spinal cord, as well as increases the latency to fall in the rotarod test in the same ALS mouse model. Cu-ATSM containing positron-emitting copper isotopes has been used in PET imaging applications for selective labeling of hypoxic tissue.{30773}
Brand:CaymanSKU:-Out of stock
CU-CPT4a is a toll-like receptor 3 (TLR3) antagonist (IC50 = 3.44 µM).{36228} It is selective for TLR3 over TLR4, TLR2/6, TLR1/2, and TLR7 at 27 µM. CU-CPT4a inhibits dsRNA binding to TLR3 with a Ki value of 2.96 µM in a fluorescence anisotropy assay. It decreases poly(I:C)-induced production of TNF-α and IL-1β in RAW 264.7 cells when used at a concentration of 27 µM.
Brand:CaymanSKU:30951 - 1 mgAvailable on backorder
CU-CPT4a is a toll-like receptor 3 (TLR3) antagonist (IC50 = 3.44 µM).{36228} It is selective for TLR3 over TLR4, TLR2/6, TLR1/2, and TLR7 at 27 µM. CU-CPT4a inhibits dsRNA binding to TLR3 with a Ki value of 2.96 µM in a fluorescence anisotropy assay. It decreases poly(I:C)-induced production of TNF-α and IL-1β in RAW 264.7 cells when used at a concentration of 27 µM.
Brand:CaymanSKU:30951 - 5 mgAvailable on backorder
CU-CPT4a is a toll-like receptor 3 (TLR3) antagonist (IC50 = 3.44 µM).{36228} It is selective for TLR3 over TLR4, TLR2/6, TLR1/2, and TLR7 at 27 µM. CU-CPT4a inhibits dsRNA binding to TLR3 with a Ki value of 2.96 µM in a fluorescence anisotropy assay. It decreases poly(I:C)-induced production of TNF-α and IL-1β in RAW 264.7 cells when used at a concentration of 27 µM.
Brand:CaymanSKU:30951 - 500 µgAvailable on backorder
CU-CPT8m is an antagonist of toll-like receptor 8 (TLR8; Kd = 220 nM; IC50 = 67 nM in a reporter assay).{35162} It is selective for TLR8 over a panel of all other human TLRs when used at a concentration of 1 μM. CU-CPT8m (1 μM) inhibits increases in TNF-α and IL-8 mRNA expression induced by the TLR8 agonist R-848 (Item No. 14806) in TLR8-overexpressing HEK-Blue cells. It also inhibits R-848-induced increases in TNF-α protein levels in differentiated THP-1 monocytes and human primary peripheral blood mononuclear cells (PBMCs) in a concentration-dependent manner. CU-CPT8m decreases TNF-α and IL-8 levels in synovial cells derived from patients with osteoarthritis and TNF-α levels in PBMCs derived from patients with rheumatoid arthritis.
Brand:CaymanSKU:25349 - 1 mgAvailable on backorder
CU-CPT8m is an antagonist of toll-like receptor 8 (TLR8; Kd = 220 nM; IC50 = 67 nM in a reporter assay).{35162} It is selective for TLR8 over a panel of all other human TLRs when used at a concentration of 1 μM. CU-CPT8m (1 μM) inhibits increases in TNF-α and IL-8 mRNA expression induced by the TLR8 agonist R-848 (Item No. 14806) in TLR8-overexpressing HEK-Blue cells. It also inhibits R-848-induced increases in TNF-α protein levels in differentiated THP-1 monocytes and human primary peripheral blood mononuclear cells (PBMCs) in a concentration-dependent manner. CU-CPT8m decreases TNF-α and IL-8 levels in synovial cells derived from patients with osteoarthritis and TNF-α levels in PBMCs derived from patients with rheumatoid arthritis.
Brand:CaymanSKU:25349 - 10 mgAvailable on backorder
CU-CPT8m is an antagonist of toll-like receptor 8 (TLR8; Kd = 220 nM; IC50 = 67 nM in a reporter assay).{35162} It is selective for TLR8 over a panel of all other human TLRs when used at a concentration of 1 μM. CU-CPT8m (1 μM) inhibits increases in TNF-α and IL-8 mRNA expression induced by the TLR8 agonist R-848 (Item No. 14806) in TLR8-overexpressing HEK-Blue cells. It also inhibits R-848-induced increases in TNF-α protein levels in differentiated THP-1 monocytes and human primary peripheral blood mononuclear cells (PBMCs) in a concentration-dependent manner. CU-CPT8m decreases TNF-α and IL-8 levels in synovial cells derived from patients with osteoarthritis and TNF-α levels in PBMCs derived from patients with rheumatoid arthritis.
Brand:CaymanSKU:25349 - 25 mgAvailable on backorder
CU-CPT8m is an antagonist of toll-like receptor 8 (TLR8; Kd = 220 nM; IC50 = 67 nM in a reporter assay).{35162} It is selective for TLR8 over a panel of all other human TLRs when used at a concentration of 1 μM. CU-CPT8m (1 μM) inhibits increases in TNF-α and IL-8 mRNA expression induced by the TLR8 agonist R-848 (Item No. 14806) in TLR8-overexpressing HEK-Blue cells. It also inhibits R-848-induced increases in TNF-α protein levels in differentiated THP-1 monocytes and human primary peripheral blood mononuclear cells (PBMCs) in a concentration-dependent manner. CU-CPT8m decreases TNF-α and IL-8 levels in synovial cells derived from patients with osteoarthritis and TNF-α levels in PBMCs derived from patients with rheumatoid arthritis.
Brand:CaymanSKU:25349 - 5 mgAvailable on backorder
CU-CPT9a is an antagonist of toll-like receptor 8 (TLR8).{35162} It inhibits activation of NF-κB induced by the TLR8 agonist R-848 (Item No. 14806) in TLR8-overexpressing HEK-Blue cells (IC50 = 0.5 nM). CU-CPT9a reverses R-848-induced increases in NF-κB p65, IRAK-4, and TRAF3 protein levels in HEK-Blue cells.
Brand:CaymanSKU:28722 - 1 mgAvailable on backorder
CU-CPT9a is an antagonist of toll-like receptor 8 (TLR8).{35162} It inhibits activation of NF-κB induced by the TLR8 agonist R-848 (Item No. 14806) in TLR8-overexpressing HEK-Blue cells (IC50 = 0.5 nM). CU-CPT9a reverses R-848-induced increases in NF-κB p65, IRAK-4, and TRAF3 protein levels in HEK-Blue cells.
Brand:CaymanSKU:28722 - 10 mgAvailable on backorder
CU-CPT9a is an antagonist of toll-like receptor 8 (TLR8).{35162} It inhibits activation of NF-κB induced by the TLR8 agonist R-848 (Item No. 14806) in TLR8-overexpressing HEK-Blue cells (IC50 = 0.5 nM). CU-CPT9a reverses R-848-induced increases in NF-κB p65, IRAK-4, and TRAF3 protein levels in HEK-Blue cells.
Brand:CaymanSKU:28722 - 25 mgAvailable on backorder
CU-CPT9a is an antagonist of toll-like receptor 8 (TLR8).{35162} It inhibits activation of NF-κB induced by the TLR8 agonist R-848 (Item No. 14806) in TLR8-overexpressing HEK-Blue cells (IC50 = 0.5 nM). CU-CPT9a reverses R-848-induced increases in NF-κB p65, IRAK-4, and TRAF3 protein levels in HEK-Blue cells.
Brand:CaymanSKU:28722 - 5 mgAvailable on backorder
CU-CPT9b is an antagonist of toll-like receptor 8 (TLR8; Kd = 21 nM).{35162} It inhibits activation of NF-ĸB induced by the TLR8 agonist R-848 (Item No. 14806) in TLR8-overexpressing HEK-Blue cells with an IC50 value of 0.7 nM.
Brand:CaymanSKU:28723 - 1 mgAvailable on backorder
CU-CPT9b is an antagonist of toll-like receptor 8 (TLR8; Kd = 21 nM).{35162} It inhibits activation of NF-ĸB induced by the TLR8 agonist R-848 (Item No. 14806) in TLR8-overexpressing HEK-Blue cells with an IC50 value of 0.7 nM.
Brand:CaymanSKU:28723 - 10 mgAvailable on backorder
CU-CPT9b is an antagonist of toll-like receptor 8 (TLR8; Kd = 21 nM).{35162} It inhibits activation of NF-ĸB induced by the TLR8 agonist R-848 (Item No. 14806) in TLR8-overexpressing HEK-Blue cells with an IC50 value of 0.7 nM.
Brand:CaymanSKU:28723 - 25 mgAvailable on backorder
CU-CPT9b is an antagonist of toll-like receptor 8 (TLR8; Kd = 21 nM).{35162} It inhibits activation of NF-ĸB induced by the TLR8 agonist R-848 (Item No. 14806) in TLR8-overexpressing HEK-Blue cells with an IC50 value of 0.7 nM.
Brand:CaymanSKU:28723 - 5 mgAvailable on backorder
Antigen: human Cu/Zn SOD · Host: rabbit · Cross Reactivity: (+) human, mouse, bovine, monkey, coral, canine, hamster, porcine, rabbit, ovine, and rat Cu/Zn SOD · Applications: EIA, IHC, IP, and WB • SOD1 contains Cu and Zn ions as a homodimer and exists in the cytoplasm where it plays a major role in antioxidant defense mechanisms by catalyzing the dismutation of the superoxide radical O2- to O2 and H2O2.
Brand:CaymanSKU:10011388- 100 µl Superoxide dismutase (SOD) is an endogenously produced intracellular enzyme present in almost every cell in the body.{15491} It works by catalyzing the dismutation of the superoxide radical O2- to O2 and H2O2, which are then metabolized to H2O and O2 by catalase and glutathione peroxidase.{15490,15493} In general, SODs play a major role in antioxidant defense mechanisms.{15492} There are two main types of SOD in mammalian cells. One form, SOD1, contains Cu and Zn ions as a homodimer and exists in the cytoplasm. The two subunits of 16 kDa each are linked by two cystines forming an intra-subunit disulphide bridge.{15491} The second form, SOD2, is a manganese-containing enzyme and resides in the mitochondrial matrix. It is a homotetramer of 80 kDa. The third form, SOD3 or EC-SOD, is like SOD1 in that it contains Cu and Zn ions, however it is distinct in that it is a homotetramer, with a mass of 30 kDa and it exists only in the extra-cellular space.{15494} SOD3 can also be distinguished by its heparin-binding capacity.{15489}
Brand:CaymanSKU:10011388 - 100 µlAvailable on backorder
Antigen: human Cu/Zn SOD · Host: rabbit · Cross Reactivity: (+) human, mouse, bovine, monkey, coral, canine, hamster, porcine, rabbit, ovine, and rat Cu/Zn SOD · Applications: EIA, IHC, IP, and WB • SOD1 contains Cu and Zn ions as a homodimer and exists in the cytoplasm where it plays a major role in antioxidant defense mechanisms by catalyzing the dismutation of the superoxide radical O2- to O2 and H2O2.
Brand:CaymanSKU:10011388- 100 µlAvailable on backorder
Antigen: human Cu/Zn SOD · Host: rabbit · Cross Reactivity: (+) human, mouse, bovine, monkey, coral, canine, hamster, porcine, rabbit, ovine, and rat Cu/Zn SOD · Applications: EIA, IHC, IP, and WB • SOD1 contains Cu and Zn ions as a homodimer and exists in the cytoplasm where it plays a major role in antioxidant defense mechanisms by catalyzing the dismutation of the superoxide radical O2- to O2 and H2O2.
Brand:CaymanSKU:10011388- 25 µl Superoxide dismutase (SOD) is an endogenously produced intracellular enzyme present in almost every cell in the body.{15491} It works by catalyzing the dismutation of the superoxide radical O2- to O2 and H2O2, which are then metabolized to H2O and O2 by catalase and glutathione peroxidase.{15490,15493} In general, SODs play a major role in antioxidant defense mechanisms.{15492} There are two main types of SOD in mammalian cells. One form, SOD1, contains Cu and Zn ions as a homodimer and exists in the cytoplasm. The two subunits of 16 kDa each are linked by two cystines forming an intra-subunit disulphide bridge.{15491} The second form, SOD2, is a manganese-containing enzyme and resides in the mitochondrial matrix. It is a homotetramer of 80 kDa. The third form, SOD3 or EC-SOD, is like SOD1 in that it contains Cu and Zn ions, however it is distinct in that it is a homotetramer, with a mass of 30 kDa and it exists only in the extra-cellular space.{15494} SOD3 can also be distinguished by its heparin-binding capacity.{15489}
Brand:CaymanSKU:10011388 - 25 µlAvailable on backorder
Antigen: human Cu/Zn SOD · Host: rabbit · Cross Reactivity: (+) human, mouse, bovine, monkey, coral, canine, hamster, porcine, rabbit, ovine, and rat Cu/Zn SOD · Applications: EIA, IHC, IP, and WB • SOD1 contains Cu and Zn ions as a homodimer and exists in the cytoplasm where it plays a major role in antioxidant defense mechanisms by catalyzing the dismutation of the superoxide radical O2- to O2 and H2O2.
Brand:CaymanSKU:10011388- 25 µlAvailable on backorder
Antigen: rat Cu/Zn SOD · Host: rabbit · Cross Reactivity: (+) human, mouse, bovine, and rat Cu/Zn SOD · Applications: IHC, IP, and WB • SOD1 contains Cu and Zn ions as a homodimer and exists in the cytoplasm where it plays a major role in antioxidant defense mechanisms by catalyzing the dismutation of the superoxide radical O2- to O2 and H2O2.
Brand:CaymanSKU:10011387- 100 µl Superoxide dismutase (SOD) is an endogenously produced intracellular enzyme present in almost every cell in the body.{15491} It works by catalyzing the dismutation of the superoxide radical O2- to O2 and H2O2, which are then metabolized to H2O and O2 by catalase and glutathione peroxidase.{15490,15493} In general, SODs play a major role in antioxidant defense mechanisms.{15492} There are two main types of SOD in mammalian cells. One form, SOD1, contains Cu and Zn ions as a homodimer and exists in the cytoplasm. The two subunits of 16 kDa each are linked by two cystines forming an intra-subunit disulphide bridge.{15491} The second form, SOD2, is a manganese containing enzyme and resides in the mitochondrial matrix. It is a homotetramer of 80 kDa. The third form, SOD3 or EC-SOD, is like SOD1 in that it contains Cu and Zn ions, however it is distinct in that it is a homotetramer, with a mass of 30 kDa and it exists only in the extra-cellular space.{15494} SOD3 can also be distinguished by its heparin-binding capacity.{15489}
Brand:CaymanSKU:10011387 - 100 µlAvailable on backorder
Antigen: rat Cu/Zn SOD · Host: rabbit · Cross Reactivity: (+) human, mouse, bovine, and rat Cu/Zn SOD · Applications: IHC, IP, and WB • SOD1 contains Cu and Zn ions as a homodimer and exists in the cytoplasm where it plays a major role in antioxidant defense mechanisms by catalyzing the dismutation of the superoxide radical O2- to O2 and H2O2.
Brand:CaymanSKU:10011387- 100 µlAvailable on backorder
Antigen: rat Cu/Zn SOD · Host: rabbit · Cross Reactivity: (+) human, mouse, bovine, and rat Cu/Zn SOD · Applications: IHC, IP, and WB • SOD1 contains Cu and Zn ions as a homodimer and exists in the cytoplasm where it plays a major role in antioxidant defense mechanisms by catalyzing the dismutation of the superoxide radical O2- to O2 and H2O2.
Brand:CaymanSKU:10011387- 25 µl Superoxide dismutase (SOD) is an endogenously produced intracellular enzyme present in almost every cell in the body.{15491} It works by catalyzing the dismutation of the superoxide radical O2- to O2 and H2O2, which are then metabolized to H2O and O2 by catalase and glutathione peroxidase.{15490,15493} In general, SODs play a major role in antioxidant defense mechanisms.{15492} There are two main types of SOD in mammalian cells. One form, SOD1, contains Cu and Zn ions as a homodimer and exists in the cytoplasm. The two subunits of 16 kDa each are linked by two cystines forming an intra-subunit disulphide bridge.{15491} The second form, SOD2, is a manganese containing enzyme and resides in the mitochondrial matrix. It is a homotetramer of 80 kDa. The third form, SOD3 or EC-SOD, is like SOD1 in that it contains Cu and Zn ions, however it is distinct in that it is a homotetramer, with a mass of 30 kDa and it exists only in the extra-cellular space.{15494} SOD3 can also be distinguished by its heparin-binding capacity.{15489}
Brand:CaymanSKU:10011387 - 25 µlAvailable on backorder
Antigen: rat Cu/Zn SOD · Host: rabbit · Cross Reactivity: (+) human, mouse, bovine, and rat Cu/Zn SOD · Applications: IHC, IP, and WB • SOD1 contains Cu and Zn ions as a homodimer and exists in the cytoplasm where it plays a major role in antioxidant defense mechanisms by catalyzing the dismutation of the superoxide radical O2- to O2 and H2O2.
Brand:CaymanSKU:10011387- 25 µlAvailable on backorder
Cucurbitacin B is a plant-derived triterpene that has the classic four-ring structure of mammalian steroids. It has diverse effects on mammalian cells, most notably inducing cell cycle arrest or apoptosis in a range of cancer cell lines.{23448,23449,30197} Cucurbitacin B inhibits the growth of several breast cancer cell lines (IC50s = 18-50 nM).{30195} It suppresses the growth of tumors developed from MDA-MB-231 and 4T-1 breast cancer cells in mice.{30195} Cucurbitacin B blocks the inflammatory response of macrophages treated with lipopolysaccharide.{30196} In Drosophila, it serves as an ecdysteroid receptor antagonist (Kd = 5 µM).{30194}
Brand:CaymanSKU:- Cucurbitacin B is a plant-derived triterpene that has the classic four-ring structure of mammalian steroids. It has diverse effects on mammalian cells, most notably inducing cell cycle arrest or apoptosis in a range of cancer cell lines.{23448,23449,30197} Cucurbitacin B inhibits the growth of several breast cancer cell lines (IC50s = 18-50 nM).{30195} It suppresses the growth of tumors developed from MDA-MB-231 and 4T-1 breast cancer cells in mice.{30195} Cucurbitacin B blocks the inflammatory response of macrophages treated with lipopolysaccharide.{30196} In Drosophila, it serves as an ecdysteroid receptor antagonist (Kd = 5 µM).{30194}
Brand:CaymanSKU:- Cucurbitacin B is a plant-derived triterpene that has the classic four-ring structure of mammalian steroids. It has diverse effects on mammalian cells, most notably inducing cell cycle arrest or apoptosis in a range of cancer cell lines.{23448,23449,30197} Cucurbitacin B inhibits the growth of several breast cancer cell lines (IC50s = 18-50 nM).{30195} It suppresses the growth of tumors developed from MDA-MB-231 and 4T-1 breast cancer cells in mice.{30195} Cucurbitacin B blocks the inflammatory response of macrophages treated with lipopolysaccharide.{30196} In Drosophila, it serves as an ecdysteroid receptor antagonist (Kd = 5 µM).{30194}
Brand:CaymanSKU:- Cucurbitacin B is a plant-derived triterpene that has the classic four-ring structure of mammalian steroids. It has diverse effects on mammalian cells, most notably inducing cell cycle arrest or apoptosis in a range of cancer cell lines.{23448,23449,30197} Cucurbitacin B inhibits the growth of several breast cancer cell lines (IC50s = 18-50 nM).{30195} It suppresses the growth of tumors developed from MDA-MB-231 and 4T-1 breast cancer cells in mice.{30195} Cucurbitacin B blocks the inflammatory response of macrophages treated with lipopolysaccharide.{30196} In Drosophila, it serves as an ecdysteroid receptor antagonist (Kd = 5 µM).{30194}
Brand:CaymanSKU:-
Cucurbitacin E is a plant-derived triterpene that has diverse biological activities. At a concentration of 10 pM, it reduces MPP+-induced death of neuronal PC12 cells through inhibition of autophagy in vitro.{38164} Cucurbitacin E inhibits growth of T24 bladder, MDA-MB-468 and MCF-7 breast, PC3 prostate, and colorectal cancer cell lines (IC50s = 50-1,000 nM) through induction of G2/M arrest and apoptosis.{38159,38160,38161} It increases bilirubin binding to human serum albumin (HSA) in human plasma in a dose-dependent manner.{38162} Cucurbitacin E also inhibits depolymerization of actin filaments isolated from rabbit skeletal muscle actin and in HeLa cells.{38163}
Brand:CaymanSKU:- Cucurbitacin E is a plant-derived triterpene that has diverse biological activities. At a concentration of 10 pM, it reduces MPP+-induced death of neuronal PC12 cells through inhibition of autophagy in vitro.{38164} Cucurbitacin E inhibits growth of T24 bladder, MDA-MB-468 and MCF-7 breast, PC3 prostate, and colorectal cancer cell lines (IC50s = 50-1,000 nM) through induction of G2/M arrest and apoptosis.{38159,38160,38161} It increases bilirubin binding to human serum albumin (HSA) in human plasma in a dose-dependent manner.{38162} Cucurbitacin E also inhibits depolymerization of actin filaments isolated from rabbit skeletal muscle actin and in HeLa cells.{38163}
Brand:CaymanSKU:- Cucurbitacin E is a plant-derived triterpene that has diverse biological activities. At a concentration of 10 pM, it reduces MPP+-induced death of neuronal PC12 cells through inhibition of autophagy in vitro.{38164} Cucurbitacin E inhibits growth of T24 bladder, MDA-MB-468 and MCF-7 breast, PC3 prostate, and colorectal cancer cell lines (IC50s = 50-1,000 nM) through induction of G2/M arrest and apoptosis.{38159,38160,38161} It increases bilirubin binding to human serum albumin (HSA) in human plasma in a dose-dependent manner.{38162} Cucurbitacin E also inhibits depolymerization of actin filaments isolated from rabbit skeletal muscle actin and in HeLa cells.{38163}
Brand:CaymanSKU:- Cucurbitacin E is a plant-derived triterpene that has diverse biological activities. At a concentration of 10 pM, it reduces MPP+-induced death of neuronal PC12 cells through inhibition of autophagy in vitro.{38164} Cucurbitacin E inhibits growth of T24 bladder, MDA-MB-468 and MCF-7 breast, PC3 prostate, and colorectal cancer cell lines (IC50s = 50-1,000 nM) through induction of G2/M arrest and apoptosis.{38159,38160,38161} It increases bilirubin binding to human serum albumin (HSA) in human plasma in a dose-dependent manner.{38162} Cucurbitacin E also inhibits depolymerization of actin filaments isolated from rabbit skeletal muscle actin and in HeLa cells.{38163}
Brand:CaymanSKU:-
Epoxyeicosatrienoic acid (EpETrE; EET) metabolites of arachidonic acid such as 11(12)-EET and 14(15)-EET have been identified as endothelium derived hyperpolarizing factors with vasodilator activity.{12391} Soluble epoxide hydrolase (sEH) catalyzes the conversion of EETs to the corresponding dihydroxy eicosatrienoic acids (DiHETrEs; DHETs) thereby diminishing their activity. CUDA is an inhibitor of sEH exhibiting IC50 values of 11.1 nM and 112 nM for the mouse and human enzymes, respectively.{14064} In COS-7 cells, 10 µM CUDA blocks conversion of 1 µM 14,15-EET to 14,15-DHET by 94%. CUDA activates peroxisome proliferator-activated receptor α (PPARα) 8-fold at a concentration of 10 µM but exhibits no affect on PPARδ or PPARγ{13447}
Brand:CaymanSKU:10007923 - 10 mgAvailable on backorder
Epoxyeicosatrienoic acid (EpETrE; EET) metabolites of arachidonic acid such as 11(12)-EET and 14(15)-EET have been identified as endothelium derived hyperpolarizing factors with vasodilator activity.{12391} Soluble epoxide hydrolase (sEH) catalyzes the conversion of EETs to the corresponding dihydroxy eicosatrienoic acids (DiHETrEs; DHETs) thereby diminishing their activity. CUDA is an inhibitor of sEH exhibiting IC50 values of 11.1 nM and 112 nM for the mouse and human enzymes, respectively.{14064} In COS-7 cells, 10 µM CUDA blocks conversion of 1 µM 14,15-EET to 14,15-DHET by 94%. CUDA activates peroxisome proliferator-activated receptor α (PPARα) 8-fold at a concentration of 10 µM but exhibits no affect on PPARδ or PPARγ{13447}
Brand:CaymanSKU:10007923 - 25 mgAvailable on backorder
Epoxyeicosatrienoic acid (EpETrE; EET) metabolites of arachidonic acid such as 11(12)-EET and 14(15)-EET have been identified as endothelium derived hyperpolarizing factors with vasodilator activity.{12391} Soluble epoxide hydrolase (sEH) catalyzes the conversion of EETs to the corresponding dihydroxy eicosatrienoic acids (DiHETrEs; DHETs) thereby diminishing their activity. CUDA is an inhibitor of sEH exhibiting IC50 values of 11.1 nM and 112 nM for the mouse and human enzymes, respectively.{14064} In COS-7 cells, 10 µM CUDA blocks conversion of 1 µM 14,15-EET to 14,15-DHET by 94%. CUDA activates peroxisome proliferator-activated receptor α (PPARα) 8-fold at a concentration of 10 µM but exhibits no affect on PPARδ or PPARγ{13447}
Brand:CaymanSKU:10007923 - 5 mgAvailable on backorder
Epoxyeicosatrienoic acid (EpETrE; EET) metabolites of arachidonic acid such as 11(12)-EET and 14(15)-EET have been identified as endothelium derived hyperpolarizing factors with vasodilator activity.{12391} Soluble epoxide hydrolase (sEH) catalyzes the conversion of EETs to the corresponding dihydroxy eicosatrienoic acids (DiHETrEs; DHETs) thereby diminishing their activity. CUDA is an inhibitor of sEH exhibiting IC50 values of 11.1 nM and 112 nM for the mouse and human enzymes, respectively.{14064} In COS-7 cells, 10 µM CUDA blocks conversion of 1 µM 14,15-EET to 14,15-DHET by 94%. CUDA activates peroxisome proliferator-activated receptor α (PPARα) 8-fold at a concentration of 10 µM but exhibits no affect on PPARδ or PPARγ{13447}
Brand:CaymanSKU:10007923 - 50 mgAvailable on backorder
CUDC-101 is a multi-target inhibitor, combining functional groups of potent inhibitors of human epidermal growth factor receptor (HER) kinases and histone deacetylases (HDACs). It potently blocks the receptor tyrosine kinases EGFR (aka HER1) and HER2 (IC50s = 2.4 and 16.4 nM, respectively).{26830} CUDC-101 also inhibits the activity of class I and class II HDACs at nanomolar concentrations (e.g., IC50s = 4.5, 12.6, 13.2, and 11.4 nM for HDAC1, 2, 4, and 5, respectively).{26830} It has only weak effects on over 60 other kinases when tested at 5 µM.{26830} CUDC-101 prevents the growth of a wide range of cancer cell lines in vitro, and slows tumor growth or induces tumor regression through cancer cell apoptosis in xenograft models.{26830} In cancer cells that have acquired resistance to single-target EGFR inhibitors, CUDC-101 blocks proliferation and reduces cell migration.{26829}
Brand:CaymanSKU:-Out of stock
CUDC-101 is a multi-target inhibitor, combining functional groups of potent inhibitors of human epidermal growth factor receptor (HER) kinases and histone deacetylases (HDACs). It potently blocks the receptor tyrosine kinases EGFR (aka HER1) and HER2 (IC50s = 2.4 and 16.4 nM, respectively).{26830} CUDC-101 also inhibits the activity of class I and class II HDACs at nanomolar concentrations (e.g., IC50s = 4.5, 12.6, 13.2, and 11.4 nM for HDAC1, 2, 4, and 5, respectively).{26830} It has only weak effects on over 60 other kinases when tested at 5 µM.{26830} CUDC-101 prevents the growth of a wide range of cancer cell lines in vitro, and slows tumor growth or induces tumor regression through cancer cell apoptosis in xenograft models.{26830} In cancer cells that have acquired resistance to single-target EGFR inhibitors, CUDC-101 blocks proliferation and reduces cell migration.{26829}
Brand:CaymanSKU:-Out of stock
CUDC-101 is a multi-target inhibitor, combining functional groups of potent inhibitors of human epidermal growth factor receptor (HER) kinases and histone deacetylases (HDACs). It potently blocks the receptor tyrosine kinases EGFR (aka HER1) and HER2 (IC50s = 2.4 and 16.4 nM, respectively).{26830} CUDC-101 also inhibits the activity of class I and class II HDACs at nanomolar concentrations (e.g., IC50s = 4.5, 12.6, 13.2, and 11.4 nM for HDAC1, 2, 4, and 5, respectively).{26830} It has only weak effects on over 60 other kinases when tested at 5 µM.{26830} CUDC-101 prevents the growth of a wide range of cancer cell lines in vitro, and slows tumor growth or induces tumor regression through cancer cell apoptosis in xenograft models.{26830} In cancer cells that have acquired resistance to single-target EGFR inhibitors, CUDC-101 blocks proliferation and reduces cell migration.{26829}
Brand:CaymanSKU:-Out of stock
CUDC-101 is a multi-target inhibitor, combining functional groups of potent inhibitors of human epidermal growth factor receptor (HER) kinases and histone deacetylases (HDACs). It potently blocks the receptor tyrosine kinases EGFR (aka HER1) and HER2 (IC50s = 2.4 and 16.4 nM, respectively).{26830} CUDC-101 also inhibits the activity of class I and class II HDACs at nanomolar concentrations (e.g., IC50s = 4.5, 12.6, 13.2, and 11.4 nM for HDAC1, 2, 4, and 5, respectively).{26830} It has only weak effects on over 60 other kinases when tested at 5 µM.{26830} CUDC-101 prevents the growth of a wide range of cancer cell lines in vitro, and slows tumor growth or induces tumor regression through cancer cell apoptosis in xenograft models.{26830} In cancer cells that have acquired resistance to single-target EGFR inhibitors, CUDC-101 blocks proliferation and reduces cell migration.{26829}
Brand:CaymanSKU:-Out of stock
CUDC-305 is an orally bioavailable inhibitor of heat shock protein 90 (Hsp90; Item Nos. 22734 | 22735).{43002} It binds to Hsp90α and Hsp90β (IC50s = 100 and 103 nM for purified protein, respectively) as well as Hsp90 isolated from non-small cell lung cancer (NSCLC) cells resistant to erlotinib (Item No. 10483; IC50 = 70 nM).{43002,43003} CUDC-305 induces degradation of Hsp90 client proteins in BT-474 breast cancer cells and inhibits proliferation of 40 human cancer cell lines (IC50s = 0.04-0.9 µM).{43002} It also reduces the levels of several oncoproteins including Akt and phosphorylated Akt, and ERK1/2 and phosphorylated ERK1/2 in a variety of cancer cell lines. CUDC-305 (40-160 mg/kg) dose-dependently reduces tumor growth in a U87MG glioblastoma mouse xenograft model and, when administered at a dose of 160 mg/kg, prolongs survival in a U87MG mouse orthotopic model.
Brand:CaymanSKU:24683 - 1 mgAvailable on backorder
CUDC-305 is an orally bioavailable inhibitor of heat shock protein 90 (Hsp90; Item Nos. 22734 | 22735).{43002} It binds to Hsp90α and Hsp90β (IC50s = 100 and 103 nM for purified protein, respectively) as well as Hsp90 isolated from non-small cell lung cancer (NSCLC) cells resistant to erlotinib (Item No. 10483; IC50 = 70 nM).{43002,43003} CUDC-305 induces degradation of Hsp90 client proteins in BT-474 breast cancer cells and inhibits proliferation of 40 human cancer cell lines (IC50s = 0.04-0.9 µM).{43002} It also reduces the levels of several oncoproteins including Akt and phosphorylated Akt, and ERK1/2 and phosphorylated ERK1/2 in a variety of cancer cell lines. CUDC-305 (40-160 mg/kg) dose-dependently reduces tumor growth in a U87MG glioblastoma mouse xenograft model and, when administered at a dose of 160 mg/kg, prolongs survival in a U87MG mouse orthotopic model.
Brand:CaymanSKU:24683 - 10 mgAvailable on backorder
CUDC-305 is an orally bioavailable inhibitor of heat shock protein 90 (Hsp90; Item Nos. 22734 | 22735).{43002} It binds to Hsp90α and Hsp90β (IC50s = 100 and 103 nM for purified protein, respectively) as well as Hsp90 isolated from non-small cell lung cancer (NSCLC) cells resistant to erlotinib (Item No. 10483; IC50 = 70 nM).{43002,43003} CUDC-305 induces degradation of Hsp90 client proteins in BT-474 breast cancer cells and inhibits proliferation of 40 human cancer cell lines (IC50s = 0.04-0.9 µM).{43002} It also reduces the levels of several oncoproteins including Akt and phosphorylated Akt, and ERK1/2 and phosphorylated ERK1/2 in a variety of cancer cell lines. CUDC-305 (40-160 mg/kg) dose-dependently reduces tumor growth in a U87MG glioblastoma mouse xenograft model and, when administered at a dose of 160 mg/kg, prolongs survival in a U87MG mouse orthotopic model.
Brand:CaymanSKU:24683 - 25 mgAvailable on backorder
CUDC-305 is an orally bioavailable inhibitor of heat shock protein 90 (Hsp90; Item Nos. 22734 | 22735).{43002} It binds to Hsp90α and Hsp90β (IC50s = 100 and 103 nM for purified protein, respectively) as well as Hsp90 isolated from non-small cell lung cancer (NSCLC) cells resistant to erlotinib (Item No. 10483; IC50 = 70 nM).{43002,43003} CUDC-305 induces degradation of Hsp90 client proteins in BT-474 breast cancer cells and inhibits proliferation of 40 human cancer cell lines (IC50s = 0.04-0.9 µM).{43002} It also reduces the levels of several oncoproteins including Akt and phosphorylated Akt, and ERK1/2 and phosphorylated ERK1/2 in a variety of cancer cell lines. CUDC-305 (40-160 mg/kg) dose-dependently reduces tumor growth in a U87MG glioblastoma mouse xenograft model and, when administered at a dose of 160 mg/kg, prolongs survival in a U87MG mouse orthotopic model.
Brand:CaymanSKU:24683 - 5 mgAvailable on backorder
CUDC-907 is a dual inhibitor of HDACs and phosphatidylinositol 3-kinases (PI3Ks).{47027} It inhibits HDAC activity in HeLa nuclear extracts (IC50 = 50s = 50s = 2/M phase and apoptosis and decreases cellular migration and invasion in FTC-133, THJ-29T, XTC-1, and 8505C thyroid cancer cell lines in a concentration-dependent manner.{47026} CUDC-907 (75 mg/kg) reduces tumor growth, the number of liver metastases, and HDAC2 expression in tumor tissue in the FTC-133 mouse xenograft model.
Brand:CaymanSKU:25651 - 10 mgAvailable on backorder
CUDC-907 is a dual inhibitor of HDACs and phosphatidylinositol 3-kinases (PI3Ks).{47027} It inhibits HDAC activity in HeLa nuclear extracts (IC50 = 50s = 50s = 2/M phase and apoptosis and decreases cellular migration and invasion in FTC-133, THJ-29T, XTC-1, and 8505C thyroid cancer cell lines in a concentration-dependent manner.{47026} CUDC-907 (75 mg/kg) reduces tumor growth, the number of liver metastases, and HDAC2 expression in tumor tissue in the FTC-133 mouse xenograft model.
Brand:CaymanSKU:25651 - 25 mgAvailable on backorder
CUDC-907 is a dual inhibitor of HDACs and phosphatidylinositol 3-kinases (PI3Ks).{47027} It inhibits HDAC activity in HeLa nuclear extracts (IC50 = 50s = 50s = 2/M phase and apoptosis and decreases cellular migration and invasion in FTC-133, THJ-29T, XTC-1, and 8505C thyroid cancer cell lines in a concentration-dependent manner.{47026} CUDC-907 (75 mg/kg) reduces tumor growth, the number of liver metastases, and HDAC2 expression in tumor tissue in the FTC-133 mouse xenograft model.
Brand:CaymanSKU:25651 - 5 mgAvailable on backorder
CUDC-907 is a dual inhibitor of HDACs and phosphatidylinositol 3-kinases (PI3Ks).{47027} It inhibits HDAC activity in HeLa nuclear extracts (IC50 = 50s = 50s = 2/M phase and apoptosis and decreases cellular migration and invasion in FTC-133, THJ-29T, XTC-1, and 8505C thyroid cancer cell lines in a concentration-dependent manner.{47026} CUDC-907 (75 mg/kg) reduces tumor growth, the number of liver metastases, and HDAC2 expression in tumor tissue in the FTC-133 mouse xenograft model.
Brand:CaymanSKU:25651 - 50 mgAvailable on backorder
CUMYL-PeGACLONE (Item No. 22696) is an analytical reference standard categorized as a synthetic cannabinoid.{37317} It has been found in Spice-like herbal blends.{37318} This product is intended for research and forensic applications.
Brand:CaymanSKU:22696 -Out of stock
CUMYL-PeGACLONE (Item No. 22696) is an analytical reference standard categorized as a synthetic cannabinoid.{37317} It has been found in Spice-like herbal blends.{37318} This product is intended for research and forensic applications.
Brand:CaymanSKU:22696 -Out of stock
AM2201 (Item No. 10707) is a potent synthetic cannabinoid (CB) developed on an indole base with Ki values of 1.0 and 2.6 nM for the central CB1 and peripheral CB2 receptors, respectively.{18696} CUMYL-PICA is a derivative of AM2201 with a PINACA-like chain that lacks the alkyl-terminal fluorine atom and where the naphthoyl group has been modified with the addition of a benzyl group. The physiological and toxicological properties of this compound have not been determined. This product is intended for research and forensic applications.
Brand:CaymanSKU:-Out of stock
AM2201 (Item No. 10707) is a potent synthetic cannabinoid (CB) developed on an indole base with Ki values of 1.0 and 2.6 nM for the central CB1 and peripheral CB2 receptors, respectively.{18696} CUMYL-PICA is a derivative of AM2201 with a PINACA-like chain that lacks the alkyl-terminal fluorine atom and where the naphthoyl group has been modified with the addition of a benzyl group. The physiological and toxicological properties of this compound have not been determined. This product is intended for research and forensic applications.
Brand:CaymanSKU:-Out of stock
AM2201 (Item No. 10707) is a potent synthetic cannabinoid (CB) developed on an indole base with Ki values of 1.0 and 2.6 nM for the central CB1 and peripheral CB2 receptors, respectively.{18696} CUMYL-PICA is a derivative of AM2201 with a PINACA-like chain that lacks the alkyl-terminal fluorine atom and where the naphthoyl group has been modified with the addition of a benzyl group. The physiological and toxicological properties of this compound have not been determined. This product is intended for research and forensic applications.
Brand:CaymanSKU:-Out of stock
CUR 61414 is a potent inhibitor of hedgehog-induced cellular activity (IC50 = 100-200 nM).{24330,24331} It binds directly with the pathway activator Smoothened (Ki = 44 nM).{20488} CUR 61414 blocks proliferation and induces apoptosis in mouse basal cell carcinoma and causes regression of basaloid lesions triggered by ultraviolet light in mouse skin.{24330,24332}
Brand:CaymanSKU:- CUR 61414 is a potent inhibitor of hedgehog-induced cellular activity (IC50 = 100-200 nM).{24330,24331} It binds directly with the pathway activator Smoothened (Ki = 44 nM).{20488} CUR 61414 blocks proliferation and induces apoptosis in mouse basal cell carcinoma and causes regression of basaloid lesions triggered by ultraviolet light in mouse skin.{24330,24332}
Brand:CaymanSKU:-
Curcumenol is a sesquiterpene that has been found in Curcuma species.{47326,47327} It is active against methicillin-resistant S. aureus (MRSA) and P. aeruginosa and cytotoxic to CEM-SS lymphoblastic leukemia cells (IC50 = 11.9 µg/ml).{47326} It also decreases cell viability of AGS human gastric carcinoma cells (IC50 = 263.34 µM).{47327}
Brand:CaymanSKU:26715 - 1 mgAvailable on backorder
Curcumenol is a sesquiterpene that has been found in Curcuma species.{47326,47327} It is active against methicillin-resistant S. aureus (MRSA) and P. aeruginosa and cytotoxic to CEM-SS lymphoblastic leukemia cells (IC50 = 11.9 µg/ml).{47326} It also decreases cell viability of AGS human gastric carcinoma cells (IC50 = 263.34 µM).{47327}
Brand:CaymanSKU:26715 - 10 mgAvailable on backorder
Curcumenol is a sesquiterpene that has been found in Curcuma species.{47326,47327} It is active against methicillin-resistant S. aureus (MRSA) and P. aeruginosa and cytotoxic to CEM-SS lymphoblastic leukemia cells (IC50 = 11.9 µg/ml).{47326} It also decreases cell viability of AGS human gastric carcinoma cells (IC50 = 263.34 µM).{47327}
Brand:CaymanSKU:26715 - 25 mgAvailable on backorder
Curcumenol is a sesquiterpene that has been found in Curcuma species.{47326,47327} It is active against methicillin-resistant S. aureus (MRSA) and P. aeruginosa and cytotoxic to CEM-SS lymphoblastic leukemia cells (IC50 = 11.9 µg/ml).{47326} It also decreases cell viability of AGS human gastric carcinoma cells (IC50 = 263.34 µM).{47327}
Brand:CaymanSKU:26715 - 5 mgAvailable on backorder
Curcumin is the major yellow pigment in turmeric and curry and has antioxidant, anti-inflammatory, and antitumor activities.{1421,42430,1420,1419} It inhibits nitric oxide (NO) production (IC50 = 6 μM) and reduces inducible nitric oxide synthase (iNOS) activity in LPS-stimulated RAW 264.7 cells.{1421} Curcumin inhibits release of histamine and the inflammatory cytokines TNF-α, IL-1β, IL-6, and IL-8 from HMC-1 mast cells.{42430} In vivo, curcumin decreases serum levels of histamine and TNF-α, inhibits histopathological changes of nasal mucosa, and decreases the number of sneezes and nasal rubbing in a mouse model of ovalbumin-induced rhinitis. Curcumin (100 or 200 mg/kg) prevents ovalbumin-induced accumulation of 3-nitrotyrosine (3-NT), a marker of oxidative stress, in mouse heart. Topical administration of curcumin (1-10 μmol) reduces the number of tumors induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in mouse skin.{1420} Dietary administration of curcumin reduces the number of tongue neoplasms and preneoplastic lesions induced by 4-nitroquinoline 1-oxide (4-NQO) in rats.{1419}
Brand:CaymanSKU:81025 - 10 gAvailable on backorder
Curcumin is the major yellow pigment in turmeric and curry and has antioxidant, anti-inflammatory, and antitumor activities.{1421,42430,1420,1419} It inhibits nitric oxide (NO) production (IC50 = 6 μM) and reduces inducible nitric oxide synthase (iNOS) activity in LPS-stimulated RAW 264.7 cells.{1421} Curcumin inhibits release of histamine and the inflammatory cytokines TNF-α, IL-1β, IL-6, and IL-8 from HMC-1 mast cells.{42430} In vivo, curcumin decreases serum levels of histamine and TNF-α, inhibits histopathological changes of nasal mucosa, and decreases the number of sneezes and nasal rubbing in a mouse model of ovalbumin-induced rhinitis. Curcumin (100 or 200 mg/kg) prevents ovalbumin-induced accumulation of 3-nitrotyrosine (3-NT), a marker of oxidative stress, in mouse heart. Topical administration of curcumin (1-10 μmol) reduces the number of tumors induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in mouse skin.{1420} Dietary administration of curcumin reduces the number of tongue neoplasms and preneoplastic lesions induced by 4-nitroquinoline 1-oxide (4-NQO) in rats.{1419}
Brand:CaymanSKU:81025 - 100 gAvailable on backorder
Curcumin is the major yellow pigment in turmeric and curry and has antioxidant, anti-inflammatory, and antitumor activities.{1421,42430,1420,1419} It inhibits nitric oxide (NO) production (IC50 = 6 μM) and reduces inducible nitric oxide synthase (iNOS) activity in LPS-stimulated RAW 264.7 cells.{1421} Curcumin inhibits release of histamine and the inflammatory cytokines TNF-α, IL-1β, IL-6, and IL-8 from HMC-1 mast cells.{42430} In vivo, curcumin decreases serum levels of histamine and TNF-α, inhibits histopathological changes of nasal mucosa, and decreases the number of sneezes and nasal rubbing in a mouse model of ovalbumin-induced rhinitis. Curcumin (100 or 200 mg/kg) prevents ovalbumin-induced accumulation of 3-nitrotyrosine (3-NT), a marker of oxidative stress, in mouse heart. Topical administration of curcumin (1-10 μmol) reduces the number of tumors induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in mouse skin.{1420} Dietary administration of curcumin reduces the number of tongue neoplasms and preneoplastic lesions induced by 4-nitroquinoline 1-oxide (4-NQO) in rats.{1419}
Brand:CaymanSKU:81025 - 5 gAvailable on backorder
Curcumin is the major yellow pigment in turmeric and curry and has antioxidant, anti-inflammatory, and antitumor activities.{1421,42430,1420,1419} It inhibits nitric oxide (NO) production (IC50 = 6 μM) and reduces inducible nitric oxide synthase (iNOS) activity in LPS-stimulated RAW 264.7 cells.{1421} Curcumin inhibits release of histamine and the inflammatory cytokines TNF-α, IL-1β, IL-6, and IL-8 from HMC-1 mast cells.{42430} In vivo, curcumin decreases serum levels of histamine and TNF-α, inhibits histopathological changes of nasal mucosa, and decreases the number of sneezes and nasal rubbing in a mouse model of ovalbumin-induced rhinitis. Curcumin (100 or 200 mg/kg) prevents ovalbumin-induced accumulation of 3-nitrotyrosine (3-NT), a marker of oxidative stress, in mouse heart. Topical administration of curcumin (1-10 μmol) reduces the number of tumors induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in mouse skin.{1420} Dietary administration of curcumin reduces the number of tongue neoplasms and preneoplastic lesions induced by 4-nitroquinoline 1-oxide (4-NQO) in rats.{1419}
Brand:CaymanSKU:81025 - 50 gAvailable on backorder
Curcumin is the major yellow pigment in turmeric and curry and has antioxidant, anti-inflammatory, and antitumor activities.{1421,42430,1420,1419} It inhibits nitric oxide (NO) production (IC50 = 6 μM) and reduces inducible nitric oxide synthase (iNOS) activity in LPS-stimulated RAW 264.7 cells.{1421} Curcumin inhibits release of histamine and the inflammatory cytokines TNF-α, IL-1β, IL-6, and IL-8 from HMC-1 mast cells.{42430} In vivo, curcumin decreases serum levels of histamine and TNF-α, inhibits histopathological changes of nasal mucosa, and decreases the number of sneezes and nasal rubbing in a mouse model of ovalbumin-induced rhinitis. Curcumin (100 or 200 mg/kg) prevents ovalbumin-induced accumulation of 3-nitrotyrosine (3-NT), a marker of oxidative stress, in mouse heart. Topical administration of curcumin (1-10 μmol) reduces the number of tumors induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in mouse skin.{1420} Dietary administration of curcumin reduces the number of tongue neoplasms and preneoplastic lesions induced by 4-nitroquinoline 1-oxide (4-NQO) in rats.{1419}
Brand:CaymanSKU:81025.1 - 10 gAvailable on backorder
Curcumin is the major yellow pigment in turmeric and curry and has antioxidant, anti-inflammatory, and antitumor activities.{1421,42430,1420,1419} It inhibits nitric oxide (NO) production (IC50 = 6 μM) and reduces inducible nitric oxide synthase (iNOS) activity in LPS-stimulated RAW 264.7 cells.{1421} Curcumin inhibits release of histamine and the inflammatory cytokines TNF-α, IL-1β, IL-6, and IL-8 from HMC-1 mast cells.{42430} In vivo, curcumin decreases serum levels of histamine and TNF-α, inhibits histopathological changes of nasal mucosa, and decreases the number of sneezes and nasal rubbing in a mouse model of ovalbumin-induced rhinitis. Curcumin (100 or 200 mg/kg) prevents ovalbumin-induced accumulation of 3-nitrotyrosine (3-NT), a marker of oxidative stress, in mouse heart. Topical administration of curcumin (1-10 μmol) reduces the number of tumors induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in mouse skin.{1420} Dietary administration of curcumin reduces the number of tongue neoplasms and preneoplastic lesions induced by 4-nitroquinoline 1-oxide (4-NQO) in rats.{1419}
Brand:CaymanSKU:81025.1 - 100 gAvailable on backorder
Curcumin is the major yellow pigment in turmeric and curry and has antioxidant, anti-inflammatory, and antitumor activities.{1421,42430,1420,1419} It inhibits nitric oxide (NO) production (IC50 = 6 μM) and reduces inducible nitric oxide synthase (iNOS) activity in LPS-stimulated RAW 264.7 cells.{1421} Curcumin inhibits release of histamine and the inflammatory cytokines TNF-α, IL-1β, IL-6, and IL-8 from HMC-1 mast cells.{42430} In vivo, curcumin decreases serum levels of histamine and TNF-α, inhibits histopathological changes of nasal mucosa, and decreases the number of sneezes and nasal rubbing in a mouse model of ovalbumin-induced rhinitis. Curcumin (100 or 200 mg/kg) prevents ovalbumin-induced accumulation of 3-nitrotyrosine (3-NT), a marker of oxidative stress, in mouse heart. Topical administration of curcumin (1-10 μmol) reduces the number of tumors induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in mouse skin.{1420} Dietary administration of curcumin reduces the number of tongue neoplasms and preneoplastic lesions induced by 4-nitroquinoline 1-oxide (4-NQO) in rats.{1419}
Brand:CaymanSKU:81025.1 - 5 gAvailable on backorder
Curcumin is the major yellow pigment in turmeric and curry and has antioxidant, anti-inflammatory, and antitumor activities.{1421,42430,1420,1419} It inhibits nitric oxide (NO) production (IC50 = 6 μM) and reduces inducible nitric oxide synthase (iNOS) activity in LPS-stimulated RAW 264.7 cells.{1421} Curcumin inhibits release of histamine and the inflammatory cytokines TNF-α, IL-1β, IL-6, and IL-8 from HMC-1 mast cells.{42430} In vivo, curcumin decreases serum levels of histamine and TNF-α, inhibits histopathological changes of nasal mucosa, and decreases the number of sneezes and nasal rubbing in a mouse model of ovalbumin-induced rhinitis. Curcumin (100 or 200 mg/kg) prevents ovalbumin-induced accumulation of 3-nitrotyrosine (3-NT), a marker of oxidative stress, in mouse heart. Topical administration of curcumin (1-10 μmol) reduces the number of tumors induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in mouse skin.{1420} Dietary administration of curcumin reduces the number of tongue neoplasms and preneoplastic lesions induced by 4-nitroquinoline 1-oxide (4-NQO) in rats.{1419}
Brand:CaymanSKU:81025.1 - 50 gAvailable on backorder
Curcumin-d6 is intended for use as an internal standard for the quantification of curcumin (Item Nos. 81025 | 81025.1) by GC- or LC-MS. Curcumin is the major yellow pigment in turmeric and curry and has antioxidant, anti-inflammatory, and antitumor activities.{1421,42430,1420,1419} It inhibits nitric oxide (NO) production (IC50 = 6 μM) and reduces inducible nitric oxide synthase (iNOS) activity in LPS-stimulated RAW 264.7 cells.{1421} Curcumin inhibits release of histamine and the inflammatory cytokines TNF-α, IL-1β, IL-6, and IL-8 from HMC-1 mast cells.{42430} In vivo, curcumin decreases serum levels of histamine and TNF-α, inhibits histopathological changes of nasal mucosa, and decreases the number of sneezes and nasal rubbing in a mouse model of ovalbumin-induced rhinitis. Curcumin (100 or 200 mg/kg) prevents ovalbumin-induced accumulation of 3-nitrotyrosine (3-NT), a marker of oxidative stress, in mouse heart. Topical administration of curcumin (1-10 μmol) reduces the number of tumors induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in mouse skin.{1420} Dietary administration of curcumin reduces the number of tongue neoplasms and preneoplastic lesions induced by 4-nitroquinoline 1-oxide (4-NQO) in rats.{1419}
Brand:CaymanSKU:25438 - 1 mgAvailable on backorder
Curcumin-d6 is intended for use as an internal standard for the quantification of curcumin (Item Nos. 81025 | 81025.1) by GC- or LC-MS. Curcumin is the major yellow pigment in turmeric and curry and has antioxidant, anti-inflammatory, and antitumor activities.{1421,42430,1420,1419} It inhibits nitric oxide (NO) production (IC50 = 6 μM) and reduces inducible nitric oxide synthase (iNOS) activity in LPS-stimulated RAW 264.7 cells.{1421} Curcumin inhibits release of histamine and the inflammatory cytokines TNF-α, IL-1β, IL-6, and IL-8 from HMC-1 mast cells.{42430} In vivo, curcumin decreases serum levels of histamine and TNF-α, inhibits histopathological changes of nasal mucosa, and decreases the number of sneezes and nasal rubbing in a mouse model of ovalbumin-induced rhinitis. Curcumin (100 or 200 mg/kg) prevents ovalbumin-induced accumulation of 3-nitrotyrosine (3-NT), a marker of oxidative stress, in mouse heart. Topical administration of curcumin (1-10 μmol) reduces the number of tumors induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in mouse skin.{1420} Dietary administration of curcumin reduces the number of tongue neoplasms and preneoplastic lesions induced by 4-nitroquinoline 1-oxide (4-NQO) in rats.{1419}
Brand:CaymanSKU:25438 - 5 mgAvailable on backorder
Curcumin-d6 is intended for use as an internal standard for the quantification of curcumin (Item Nos. 81025 | 81025.1) by GC- or LC-MS. Curcumin is the major yellow pigment in turmeric and curry and has antioxidant, anti-inflammatory, and antitumor activities.{1421,42430,1420,1419} It inhibits nitric oxide (NO) production (IC50 = 6 μM) and reduces inducible nitric oxide synthase (iNOS) activity in LPS-stimulated RAW 264.7 cells.{1421} Curcumin inhibits release of histamine and the inflammatory cytokines TNF-α, IL-1β, IL-6, and IL-8 from HMC-1 mast cells.{42430} In vivo, curcumin decreases serum levels of histamine and TNF-α, inhibits histopathological changes of nasal mucosa, and decreases the number of sneezes and nasal rubbing in a mouse model of ovalbumin-induced rhinitis. Curcumin (100 or 200 mg/kg) prevents ovalbumin-induced accumulation of 3-nitrotyrosine (3-NT), a marker of oxidative stress, in mouse heart. Topical administration of curcumin (1-10 μmol) reduces the number of tumors induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in mouse skin.{1420} Dietary administration of curcumin reduces the number of tongue neoplasms and preneoplastic lesions induced by 4-nitroquinoline 1-oxide (4-NQO) in rats.{1419}
Brand:CaymanSKU:25438 - 500 µgAvailable on backorder
Curcumol is a sesquiterpene alcohol that has been found in Curcumae oil and has diverse biological activities.{48354,48355,48356,48357} It is a positive allosteric modulator (PAM) of GABAA receptors that potentiates GABA-induced currents in the presence of the benzodiazepine GABA agonist diazepam, but not the GABAA PAM (–)-menthol, in mouse hippocampal neurons.{48354} Curcumol (1-200 μg/ml) reduces activation of proinflammatory NF-κB and profibrotic TGF-β1/SMAD signaling pathways in RAW 264.7 cells stimulated with cigarette smoke extract.{48355} It inhibits proliferation of and induces apoptosis in LoVo and SW480 colorectal cancer cells in a concentration-dependent manner.{48356} In vivo, curcumol (20-80 mg/kg) reduces tumor volume in a LoVo mouse xenograft model. Curcumol also increases the rate of wound closure in rats with diabetes induced by streptozotocin (Item No. 13104).{48357}
Brand:CaymanSKU:26849 - 10 mgAvailable on backorder
Curcumol is a sesquiterpene alcohol that has been found in Curcumae oil and has diverse biological activities.{48354,48355,48356,48357} It is a positive allosteric modulator (PAM) of GABAA receptors that potentiates GABA-induced currents in the presence of the benzodiazepine GABA agonist diazepam, but not the GABAA PAM (–)-menthol, in mouse hippocampal neurons.{48354} Curcumol (1-200 μg/ml) reduces activation of proinflammatory NF-κB and profibrotic TGF-β1/SMAD signaling pathways in RAW 264.7 cells stimulated with cigarette smoke extract.{48355} It inhibits proliferation of and induces apoptosis in LoVo and SW480 colorectal cancer cells in a concentration-dependent manner.{48356} In vivo, curcumol (20-80 mg/kg) reduces tumor volume in a LoVo mouse xenograft model. Curcumol also increases the rate of wound closure in rats with diabetes induced by streptozotocin (Item No. 13104).{48357}
Brand:CaymanSKU:26849 - 100 mgAvailable on backorder
Curcumol is a sesquiterpene alcohol that has been found in Curcumae oil and has diverse biological activities.{48354,48355,48356,48357} It is a positive allosteric modulator (PAM) of GABAA receptors that potentiates GABA-induced currents in the presence of the benzodiazepine GABA agonist diazepam, but not the GABAA PAM (–)-menthol, in mouse hippocampal neurons.{48354} Curcumol (1-200 μg/ml) reduces activation of proinflammatory NF-κB and profibrotic TGF-β1/SMAD signaling pathways in RAW 264.7 cells stimulated with cigarette smoke extract.{48355} It inhibits proliferation of and induces apoptosis in LoVo and SW480 colorectal cancer cells in a concentration-dependent manner.{48356} In vivo, curcumol (20-80 mg/kg) reduces tumor volume in a LoVo mouse xenograft model. Curcumol also increases the rate of wound closure in rats with diabetes induced by streptozotocin (Item No. 13104).{48357}
Brand:CaymanSKU:26849 - 25 mgAvailable on backorder
Curcumol is a sesquiterpene alcohol that has been found in Curcumae oil and has diverse biological activities.{48354,48355,48356,48357} It is a positive allosteric modulator (PAM) of GABAA receptors that potentiates GABA-induced currents in the presence of the benzodiazepine GABA agonist diazepam, but not the GABAA PAM (–)-menthol, in mouse hippocampal neurons.{48354} Curcumol (1-200 μg/ml) reduces activation of proinflammatory NF-κB and profibrotic TGF-β1/SMAD signaling pathways in RAW 264.7 cells stimulated with cigarette smoke extract.{48355} It inhibits proliferation of and induces apoptosis in LoVo and SW480 colorectal cancer cells in a concentration-dependent manner.{48356} In vivo, curcumol (20-80 mg/kg) reduces tumor volume in a LoVo mouse xenograft model. Curcumol also increases the rate of wound closure in rats with diabetes induced by streptozotocin (Item No. 13104).{48357}
Brand:CaymanSKU:26849 - 50 mgAvailable on backorder
Curdione is a sesquiterpene that has been found in C. wenyujin and has diverse biological activities. It reduces the cytopathic effect of influenza A in MDCK cells (IC50 = 28.32 μM).{52521} Curdione (100 μM) inhibits thrombin-induced aggregation, AMP-activated protein kinase (AMPK) and integrin αIIbβ3 phosphorylation, and increases in talin and vinculin levels in washed platelets.{52522} It inhibits prostaglandin E2 (PGE2; Item No. 14010) production in LPS-stimulated RAW 264.7 macrophages (IC50 = 1.12 μM).{52523}
Brand:CaymanSKU:30365 - 1 mgAvailable on backorder
Curdione is a sesquiterpene that has been found in C. wenyujin and has diverse biological activities. It reduces the cytopathic effect of influenza A in MDCK cells (IC50 = 28.32 μM).{52521} Curdione (100 μM) inhibits thrombin-induced aggregation, AMP-activated protein kinase (AMPK) and integrin αIIbβ3 phosphorylation, and increases in talin and vinculin levels in washed platelets.{52522} It inhibits prostaglandin E2 (PGE2; Item No. 14010) production in LPS-stimulated RAW 264.7 macrophages (IC50 = 1.12 μM).{52523}
Brand:CaymanSKU:30365 - 5 mgAvailable on backorder
Curdione is a sesquiterpene that has been found in C. wenyujin and has diverse biological activities. It reduces the cytopathic effect of influenza A in MDCK cells (IC50 = 28.32 μM).{52521} Curdione (100 μM) inhibits thrombin-induced aggregation, AMP-activated protein kinase (AMPK) and integrin αIIbβ3 phosphorylation, and increases in talin and vinculin levels in washed platelets.{52522} It inhibits prostaglandin E2 (PGE2; Item No. 14010) production in LPS-stimulated RAW 264.7 macrophages (IC50 = 1.12 μM).{52523}
Brand:CaymanSKU:30365 - 500 µgAvailable on backorder