Cayman
Showing 15751–15900 of 45550 results
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Clevidipine is an inhibitor of L-type calcium channels (IC50s = 7.1 and 78.8 nM at -40 and -80 mV, respectively, in isolated guinea pig cardiomyocytes).{36177} It preferentially inhibits L-type calcium channels in isolated rat portal vein over rat left ventricle (IC50s = 427 and 20,417 nM, respectively).{36176} Clevidipine decreases mean arterial pressure in anesthetized normotensive or spontaneously hypertensive rats with ED30 values of 316 and 58 nmol/kg, respectively. Formulations containing clevidipine have been used in the treatment of hypertension.
Brand:CaymanSKU:23025 - 100 mgAvailable on backorder
Clevidipine is an inhibitor of L-type calcium channels (IC50s = 7.1 and 78.8 nM at -40 and -80 mV, respectively, in isolated guinea pig cardiomyocytes).{36177} It preferentially inhibits L-type calcium channels in isolated rat portal vein over rat left ventricle (IC50s = 427 and 20,417 nM, respectively).{36176} Clevidipine decreases mean arterial pressure in anesthetized normotensive or spontaneously hypertensive rats with ED30 values of 316 and 58 nmol/kg, respectively. Formulations containing clevidipine have been used in the treatment of hypertension.
Brand:CaymanSKU:23025 - 25 mgAvailable on backorder
Clevidipine is an inhibitor of L-type calcium channels (IC50s = 7.1 and 78.8 nM at -40 and -80 mV, respectively, in isolated guinea pig cardiomyocytes).{36177} It preferentially inhibits L-type calcium channels in isolated rat portal vein over rat left ventricle (IC50s = 427 and 20,417 nM, respectively).{36176} Clevidipine decreases mean arterial pressure in anesthetized normotensive or spontaneously hypertensive rats with ED30 values of 316 and 58 nmol/kg, respectively. Formulations containing clevidipine have been used in the treatment of hypertension.
Brand:CaymanSKU:23025 - 50 mgAvailable on backorder
Clevudine is a β-L-nucleoside analog of thymidine (Item No. 20519) that has antiviral activity.{53860,53861,53862} It is active against hepatitis B virus (HBV) in HepG2/2.15 cells with an EC50 value of 0.1 µM.{53862} Clevudine (0.01-10 µM) reduces virion DNA in the culture supernatant of primary hepatocytes isolated from a duckling model of chronic HBV infection.{53863} Oral administration of clevudine (3 and 10 mg/kg) reduces serum viral load in a woodchuck model of chronic HBV infection.{53864}
Brand:CaymanSKU:30612 - 100 mgAvailable on backorder
Clevudine is a β-L-nucleoside analog of thymidine (Item No. 20519) that has antiviral activity.{53860,53861,53862} It is active against hepatitis B virus (HBV) in HepG2/2.15 cells with an EC50 value of 0.1 µM.{53862} Clevudine (0.01-10 µM) reduces virion DNA in the culture supernatant of primary hepatocytes isolated from a duckling model of chronic HBV infection.{53863} Oral administration of clevudine (3 and 10 mg/kg) reduces serum viral load in a woodchuck model of chronic HBV infection.{53864}
Brand:CaymanSKU:30612 - 250 mgAvailable on backorder
Clevudine is a β-L-nucleoside analog of thymidine (Item No. 20519) that has antiviral activity.{53860,53861,53862} It is active against hepatitis B virus (HBV) in HepG2/2.15 cells with an EC50 value of 0.1 µM.{53862} Clevudine (0.01-10 µM) reduces virion DNA in the culture supernatant of primary hepatocytes isolated from a duckling model of chronic HBV infection.{53863} Oral administration of clevudine (3 and 10 mg/kg) reduces serum viral load in a woodchuck model of chronic HBV infection.{53864}
Brand:CaymanSKU:30612 - 50 mgAvailable on backorder
Clevudine is a β-L-nucleoside analog of thymidine (Item No. 20519) that has antiviral activity.{53860,53861,53862} It is active against hepatitis B virus (HBV) in HepG2/2.15 cells with an EC50 value of 0.1 µM.{53862} Clevudine (0.01-10 µM) reduces virion DNA in the culture supernatant of primary hepatocytes isolated from a duckling model of chronic HBV infection.{53863} Oral administration of clevudine (3 and 10 mg/kg) reduces serum viral load in a woodchuck model of chronic HBV infection.{53864}
Brand:CaymanSKU:30612 - 500 mgAvailable on backorder
![A gastrointestinal muscarinic receptor antagonist (Ki = 3 nM against [3H]quinuclidinyl benzilate binding in rat colonic enterocytes); a dose of 1 mg/kg slows intestinal transit and induces constipation in mice; induces serum hyperammonemia; decreases clonic](https://interpriseusa.com/wp-content/uploads/2021/06/21428.png)
Clidinium is a gastrointestinal muscarinic receptor antagonist (Ki = 3 nM against [3H]quinuclidinyl benzilate binding in rat colonic enterocytes).{39282} Administration of clidinium, at a dose of 1 mg/kg, slows intestinal transit and induces constipation in mice.{39283} This clidinium-induced constipation induces serum hyperammonemia and decreases clonic, myoclonic, and tonic seizure thresholds in a murine pentylenetetrazole-induced epilepsy model.
Brand:CaymanSKU:21428 -Out of stock
Clidinium is a gastrointestinal muscarinic receptor antagonist (Ki = 3 nM against [3H]quinuclidinyl benzilate binding in rat colonic enterocytes).{39282} Administration of clidinium, at a dose of 1 mg/kg, slows intestinal transit and induces constipation in mice.{39283} This clidinium-induced constipation induces serum hyperammonemia and decreases clonic, myoclonic, and tonic seizure thresholds in a murine pentylenetetrazole-induced epilepsy model.
Brand:CaymanSKU:21428 -Out of stock
Clinafloxacin is a fluoroquinolone antibiotic that displays broad-spectrum antibacterial activity against Gram-positive, Gram-negative, and anaerobic pathogens by inhibiting the bacterial regulatory enzyme DNA gyrase (IC50 = 0.92 µg/ml) as well as topoisomerase IV (IC50 = 1.62 µg/ml).{27493,27494}
Brand:CaymanSKU:-Out of stock
Clinafloxacin is a fluoroquinolone antibiotic that displays broad-spectrum antibacterial activity against Gram-positive, Gram-negative, and anaerobic pathogens by inhibiting the bacterial regulatory enzyme DNA gyrase (IC50 = 0.92 µg/ml) as well as topoisomerase IV (IC50 = 1.62 µg/ml).{27493,27494}
Brand:CaymanSKU:-Out of stock
Clinafloxacin is a fluoroquinolone antibiotic that displays broad-spectrum antibacterial activity against Gram-positive, Gram-negative, and anaerobic pathogens by inhibiting the bacterial regulatory enzyme DNA gyrase (IC50 = 0.92 µg/ml) as well as topoisomerase IV (IC50 = 1.62 µg/ml).{27493,27494}
Brand:CaymanSKU:-Out of stock
Clinafloxacin is a fluoroquinolone antibiotic that displays broad-spectrum antibacterial activity against Gram-positive, Gram-negative, and anaerobic pathogens by inhibiting the bacterial regulatory enzyme DNA gyrase (IC50 = 0.92 µg/ml) as well as topoisomerase IV (IC50 = 1.62 µg/ml).{27493,27494}
Brand:CaymanSKU:-Out of stock
Clindamycin is an antibiotic in the lincosamide class which binds the bacterial 50S ribosomal subunit and interferes with protein synthesis.{22536,22537} Evidence suggests that clindamycin is particularly effective against anaerobes and is commonly used against Gram positive bacteria.{22536,22537,22530} It is used for serious infections and in the prevention of emerging infections in burns.{22530,22532,22529,22528} Clindamycin is also effective against P. falciparum and is used as an antimalarial, either alone or in combination therapy.{22531}
Brand:CaymanSKU:- Clindamycin is an antibiotic in the lincosamide class which binds the bacterial 50S ribosomal subunit and interferes with protein synthesis.{22536,22537} Evidence suggests that clindamycin is particularly effective against anaerobes and is commonly used against Gram positive bacteria.{22536,22537,22530} It is used for serious infections and in the prevention of emerging infections in burns.{22530,22532,22529,22528} Clindamycin is also effective against P. falciparum and is used as an antimalarial, either alone or in combination therapy.{22531}
Brand:CaymanSKU:- Clindamycin is an antibiotic in the lincosamide class which binds the bacterial 50S ribosomal subunit and interferes with protein synthesis.{22536,22537} Evidence suggests that clindamycin is particularly effective against anaerobes and is commonly used against Gram positive bacteria.{22536,22537,22530} It is used for serious infections and in the prevention of emerging infections in burns.{22530,22532,22529,22528} Clindamycin is also effective against P. falciparum and is used as an antimalarial, either alone or in combination therapy.{22531}
Brand:CaymanSKU:-
Clindamycin palmitate is a water-soluble prodrug form of the antibiotic clindamycin (Item No. 15006).{46531} It undergoes rapid hydrolysis in vivo to release active clindamycin. Formulations containing clindamycin palmitate have been used in the treatment of various bacterial infections.
Brand:CaymanSKU:29102 - 100 mgAvailable on backorder
Clindamycin palmitate is a water-soluble prodrug form of the antibiotic clindamycin (Item No. 15006).{46531} It undergoes rapid hydrolysis in vivo to release active clindamycin. Formulations containing clindamycin palmitate have been used in the treatment of various bacterial infections.
Brand:CaymanSKU:29102 - 250 mgAvailable on backorder
Clindamycin palmitate is a water-soluble prodrug form of the antibiotic clindamycin (Item No. 15006).{46531} It undergoes rapid hydrolysis in vivo to release active clindamycin. Formulations containing clindamycin palmitate have been used in the treatment of various bacterial infections.
Brand:CaymanSKU:29102 - 50 mgAvailable on backorder
Clindamycin palmitate is a water-soluble prodrug form of the antibiotic clindamycin (Item No. 15006).{46531} It undergoes rapid hydrolysis in vivo to release active clindamycin. Formulations containing clindamycin palmitate have been used in the treatment of various bacterial infections.
Brand:CaymanSKU:29102 - 500 mgAvailable on backorder
Clindamycin sulfoxide is an active metabolite of the antibiotic clindamycin (Item No. 15006).{48218} It is formed via S-oxidation of clindamycin primarily by the cytochrome P450 (CYP) isoform CYP3A4. Clindamycin sulfoxide inhibits the growth of P. prevotti, B. fragilis, and C. sordelli in vitro with MIC values of 2, 2, and 1 mg/L, respectively.{48219}
Brand:CaymanSKU:21696 -Out of stock
Clindamycin sulfoxide is an active metabolite of the antibiotic clindamycin (Item No. 15006).{48218} It is formed via S-oxidation of clindamycin primarily by the cytochrome P450 (CYP) isoform CYP3A4. Clindamycin sulfoxide inhibits the growth of P. prevotti, B. fragilis, and C. sordelli in vitro with MIC values of 2, 2, and 1 mg/L, respectively.{48219}
Brand:CaymanSKU:21696 -Out of stock
Clindamycin sulfoxide is an active metabolite of the antibiotic clindamycin (Item No. 15006).{48218} It is formed via S-oxidation of clindamycin primarily by the cytochrome P450 (CYP) isoform CYP3A4. Clindamycin sulfoxide inhibits the growth of P. prevotti, B. fragilis, and C. sordelli in vitro with MIC values of 2, 2, and 1 mg/L, respectively.{48219}
Brand:CaymanSKU:21696 -Out of stock
Clinofibrate is a hypolipidemic agent.{57093} It inhibits HMG-CoA reductase (IC50 = 0.47 mM) and stimulates the S-indan-1-ol dehydrogenase activity of the human liver 3α-hydroxysteroid dehydrogenase isoform AKR 1C4 in a concentration-dependent manner.{57094} Clinofibrate (10 and 30 mg/kg) reduces serum cholesterol and triglyceride levels in rats fed a normal chow pellet diet or a semisynthetic diet containing sucrose as the only carbohydrate source.
Brand:CaymanSKU:31109 - 10 mgAvailable on backorder
Clinofibrate is a hypolipidemic agent.{57093} It inhibits HMG-CoA reductase (IC50 = 0.47 mM) and stimulates the S-indan-1-ol dehydrogenase activity of the human liver 3α-hydroxysteroid dehydrogenase isoform AKR 1C4 in a concentration-dependent manner.{57094} Clinofibrate (10 and 30 mg/kg) reduces serum cholesterol and triglyceride levels in rats fed a normal chow pellet diet or a semisynthetic diet containing sucrose as the only carbohydrate source.
Brand:CaymanSKU:31109 - 100 mgAvailable on backorder
Clinofibrate is a hypolipidemic agent.{57093} It inhibits HMG-CoA reductase (IC50 = 0.47 mM) and stimulates the S-indan-1-ol dehydrogenase activity of the human liver 3α-hydroxysteroid dehydrogenase isoform AKR 1C4 in a concentration-dependent manner.{57094} Clinofibrate (10 and 30 mg/kg) reduces serum cholesterol and triglyceride levels in rats fed a normal chow pellet diet or a semisynthetic diet containing sucrose as the only carbohydrate source.
Brand:CaymanSKU:31109 - 25 mgAvailable on backorder
Clinofibrate is a hypolipidemic agent.{57093} It inhibits HMG-CoA reductase (IC50 = 0.47 mM) and stimulates the S-indan-1-ol dehydrogenase activity of the human liver 3α-hydroxysteroid dehydrogenase isoform AKR 1C4 in a concentration-dependent manner.{57094} Clinofibrate (10 and 30 mg/kg) reduces serum cholesterol and triglyceride levels in rats fed a normal chow pellet diet or a semisynthetic diet containing sucrose as the only carbohydrate source.
Brand:CaymanSKU:31109 - 50 mgAvailable on backorder
Clioquinol is a metal-chelating antimicrobial agent with neuroprotective properties.{46036,46037,46038} It inhibits the growth of A. fumigatus with MIC values of 1, >32, 8, and 16 µg/ml in media containing no metal, iron, zinc, and copper, respectively.{46036} Clioquinol (37 mg/kg) decreases neuronal loss in the substantia nigra pars compacta (SNc) and increases time spent in the novel arm of a Y-maze in the α-synuclein hA53T transgenic mouse model of Parkinson’s disease.{46037} It reduces brain atrophy and iron content, increases nigral tyrosine hydroxylase phosphorylation, and rescues behavioral impairments in the rotarod and Y-maze tests in tau knockout mice.{46038}
Brand:CaymanSKU:10021 - 10 mgAvailable on backorder
Clioquinol is a metal-chelating antimicrobial agent with neuroprotective properties.{46036,46037,46038} It inhibits the growth of A. fumigatus with MIC values of 1, >32, 8, and 16 µg/ml in media containing no metal, iron, zinc, and copper, respectively.{46036} Clioquinol (37 mg/kg) decreases neuronal loss in the substantia nigra pars compacta (SNc) and increases time spent in the novel arm of a Y-maze in the α-synuclein hA53T transgenic mouse model of Parkinson’s disease.{46037} It reduces brain atrophy and iron content, increases nigral tyrosine hydroxylase phosphorylation, and rescues behavioral impairments in the rotarod and Y-maze tests in tau knockout mice.{46038}
Brand:CaymanSKU:10021 - 250 mgAvailable on backorder
Clioquinol is a metal-chelating antimicrobial agent with neuroprotective properties.{46036,46037,46038} It inhibits the growth of A. fumigatus with MIC values of 1, >32, 8, and 16 µg/ml in media containing no metal, iron, zinc, and copper, respectively.{46036} Clioquinol (37 mg/kg) decreases neuronal loss in the substantia nigra pars compacta (SNc) and increases time spent in the novel arm of a Y-maze in the α-synuclein hA53T transgenic mouse model of Parkinson’s disease.{46037} It reduces brain atrophy and iron content, increases nigral tyrosine hydroxylase phosphorylation, and rescues behavioral impairments in the rotarod and Y-maze tests in tau knockout mice.{46038}
Brand:CaymanSKU:10021 - 5 mgAvailable on backorder
Clioquinol is a metal-chelating antimicrobial agent with neuroprotective properties.{46036,46037,46038} It inhibits the growth of A. fumigatus with MIC values of 1, >32, 8, and 16 µg/ml in media containing no metal, iron, zinc, and copper, respectively.{46036} Clioquinol (37 mg/kg) decreases neuronal loss in the substantia nigra pars compacta (SNc) and increases time spent in the novel arm of a Y-maze in the α-synuclein hA53T transgenic mouse model of Parkinson’s disease.{46037} It reduces brain atrophy and iron content, increases nigral tyrosine hydroxylase phosphorylation, and rescues behavioral impairments in the rotarod and Y-maze tests in tau knockout mice.{46038}
Brand:CaymanSKU:10021 - 50 mgAvailable on backorder
Clobenpropit is a selective histamine H3 receptor antagonist (Ki = 0.17 nM in rat cortical membranes).{19493} Clobenpropit (0.3, 0.1, and 3 nM) reduces inhibition of electrically induced contractions in isolated guinea pig ileum longitudinal muscle by the H3 receptor agonist (R)-α-methylhistamine (Item No. 25601). It does not inhibit histamine-induced contractions in isolated guinea pig ileum or tachycardia in isolated right atria at concentrations up to 1 μM, indicating a lack of functional antagonist activity at H1 and H2 receptors, respectively. Clobenpropit (1 and 3 mg/kg) decreases the duration of the tonic, clonic, and convulsive coma phases of electrically induced convulsions in mice, an effect that can be blocked by (R)-α-methylhistamine or imetit (Item No. 29517).{53229} Clobenpropit (0.1 μM) also increases GABA release and inhibits NMDA-induced neurotoxicity in primary rat cortical neurons.{16494}
Brand:CaymanSKU:10011126 - 1 mgAvailable on backorder
Clobenpropit is a selective histamine H3 receptor antagonist (Ki = 0.17 nM in rat cortical membranes).{19493} Clobenpropit (0.3, 0.1, and 3 nM) reduces inhibition of electrically induced contractions in isolated guinea pig ileum longitudinal muscle by the H3 receptor agonist (R)-α-methylhistamine (Item No. 25601). It does not inhibit histamine-induced contractions in isolated guinea pig ileum or tachycardia in isolated right atria at concentrations up to 1 μM, indicating a lack of functional antagonist activity at H1 and H2 receptors, respectively. Clobenpropit (1 and 3 mg/kg) decreases the duration of the tonic, clonic, and convulsive coma phases of electrically induced convulsions in mice, an effect that can be blocked by (R)-α-methylhistamine or imetit (Item No. 29517).{53229} Clobenpropit (0.1 μM) also increases GABA release and inhibits NMDA-induced neurotoxicity in primary rat cortical neurons.{16494}
Brand:CaymanSKU:10011126 - 10 mgAvailable on backorder
Clobenpropit is a selective histamine H3 receptor antagonist (Ki = 0.17 nM in rat cortical membranes).{19493} Clobenpropit (0.3, 0.1, and 3 nM) reduces inhibition of electrically induced contractions in isolated guinea pig ileum longitudinal muscle by the H3 receptor agonist (R)-α-methylhistamine (Item No. 25601). It does not inhibit histamine-induced contractions in isolated guinea pig ileum or tachycardia in isolated right atria at concentrations up to 1 μM, indicating a lack of functional antagonist activity at H1 and H2 receptors, respectively. Clobenpropit (1 and 3 mg/kg) decreases the duration of the tonic, clonic, and convulsive coma phases of electrically induced convulsions in mice, an effect that can be blocked by (R)-α-methylhistamine or imetit (Item No. 29517).{53229} Clobenpropit (0.1 μM) also increases GABA release and inhibits NMDA-induced neurotoxicity in primary rat cortical neurons.{16494}
Brand:CaymanSKU:10011126 - 25 mgAvailable on backorder
Clobenpropit is a selective histamine H3 receptor antagonist (Ki = 0.17 nM in rat cortical membranes).{19493} Clobenpropit (0.3, 0.1, and 3 nM) reduces inhibition of electrically induced contractions in isolated guinea pig ileum longitudinal muscle by the H3 receptor agonist (R)-α-methylhistamine (Item No. 25601). It does not inhibit histamine-induced contractions in isolated guinea pig ileum or tachycardia in isolated right atria at concentrations up to 1 μM, indicating a lack of functional antagonist activity at H1 and H2 receptors, respectively. Clobenpropit (1 and 3 mg/kg) decreases the duration of the tonic, clonic, and convulsive coma phases of electrically induced convulsions in mice, an effect that can be blocked by (R)-α-methylhistamine or imetit (Item No. 29517).{53229} Clobenpropit (0.1 μM) also increases GABA release and inhibits NMDA-induced neurotoxicity in primary rat cortical neurons.{16494}
Brand:CaymanSKU:10011126 - 5 mgAvailable on backorder
Clobetasol propionate is a corticosteroid that potently activates the glucocorticoid receptor (IC50 = 3 nM).{33297} Formulations containing clobetasol propionate are used topically to suppress inflammatory skin conditions.{33296,33298}
Brand:CaymanSKU:21251 -Out of stock
Clobetasol propionate is a corticosteroid that potently activates the glucocorticoid receptor (IC50 = 3 nM).{33297} Formulations containing clobetasol propionate are used topically to suppress inflammatory skin conditions.{33296,33298}
Brand:CaymanSKU:21251 -Out of stock
Clobetasol propionate is a corticosteroid that potently activates the glucocorticoid receptor (IC50 = 3 nM).{33297} Formulations containing clobetasol propionate are used topically to suppress inflammatory skin conditions.{33296,33298}
Brand:CaymanSKU:21251 -Out of stock
Clobetasol propionate is a corticosteroid that potently activates the glucocorticoid receptor (IC50 = 3 nM).{33297} Formulations containing clobetasol propionate are used topically to suppress inflammatory skin conditions.{33296,33298}
Brand:CaymanSKU:21251 -Out of stock
Bisphosphonates bind strongly to bone and reduce bone resorption through effects on both osteoclasts and osteoblasts.{18288,18285} Clodronate is a non-nitrogenous bisphosphonate that has been used in the treatment of osteoporosis and other metabolic bone diseases. It binds to hydroxyapatite crystals with an affinity constant of 0.72 µM, inhibiting their growth (IC50 = 1.34 µM) and bone resorption.{24450} Clondronate is metabolized intracellularly to a β-γ-methylene analog of ATP that is cytotoxic to both osteoclasts and macrophages, which belong to the same cell lineage as osteoclasts.{26453} Liposome-encapsulated bisphosphonates such as clodronate have been used in biological research to selectively deplete macrophage-like cells and cancer cells.{26454}
Brand:CaymanSKU:- Bisphosphonates bind strongly to bone and reduce bone resorption through effects on both osteoclasts and osteoblasts.{18288,18285} Clodronate is a non-nitrogenous bisphosphonate that has been used in the treatment of osteoporosis and other metabolic bone diseases. It binds to hydroxyapatite crystals with an affinity constant of 0.72 µM, inhibiting their growth (IC50 = 1.34 µM) and bone resorption.{24450} Clondronate is metabolized intracellularly to a β-γ-methylene analog of ATP that is cytotoxic to both osteoclasts and macrophages, which belong to the same cell lineage as osteoclasts.{26453} Liposome-encapsulated bisphosphonates such as clodronate have been used in biological research to selectively deplete macrophage-like cells and cancer cells.{26454}
Brand:CaymanSKU:- Bisphosphonates bind strongly to bone and reduce bone resorption through effects on both osteoclasts and osteoblasts.{18288,18285} Clodronate is a non-nitrogenous bisphosphonate that has been used in the treatment of osteoporosis and other metabolic bone diseases. It binds to hydroxyapatite crystals with an affinity constant of 0.72 µM, inhibiting their growth (IC50 = 1.34 µM) and bone resorption.{24450} Clondronate is metabolized intracellularly to a β-γ-methylene analog of ATP that is cytotoxic to both osteoclasts and macrophages, which belong to the same cell lineage as osteoclasts.{26453} Liposome-encapsulated bisphosphonates such as clodronate have been used in biological research to selectively deplete macrophage-like cells and cancer cells.{26454}
Brand:CaymanSKU:- Bisphosphonates bind strongly to bone and reduce bone resorption through effects on both osteoclasts and osteoblasts.{18288,18285} Clodronate is a non-nitrogenous bisphosphonate that has been used in the treatment of osteoporosis and other metabolic bone diseases. It binds to hydroxyapatite crystals with an affinity constant of 0.72 µM, inhibiting their growth (IC50 = 1.34 µM) and bone resorption.{24450} Clondronate is metabolized intracellularly to a β-γ-methylene analog of ATP that is cytotoxic to both osteoclasts and macrophages, which belong to the same cell lineage as osteoclasts.{26453} Liposome-encapsulated bisphosphonates such as clodronate have been used in biological research to selectively deplete macrophage-like cells and cancer cells.{26454}
Brand:CaymanSKU:-
Clofarabine is a nucleoside analog that inhibits ribonucleotide reductase and DNA polymerase-α (IC50s = 65 and 3.9 nM, respectively) and is cytotoxic to K562 myelogenous leukemia cells (IC50 = 5 nM).{22561} It induces apoptosis in primary chronic lymphocytic leukemia cells by directly altering mitochondrial transmembrane potential.{22560} Clofarabine demonstrates growth inhibition and cytotoxic activity in a variety of leukemias and solid tumors.{22558,22559,22562}
Brand:CaymanSKU:- Clofarabine is a nucleoside analog that inhibits ribonucleotide reductase and DNA polymerase-α (IC50s = 65 and 3.9 nM, respectively) and is cytotoxic to K562 myelogenous leukemia cells (IC50 = 5 nM).{22561} It induces apoptosis in primary chronic lymphocytic leukemia cells by directly altering mitochondrial transmembrane potential.{22560} Clofarabine demonstrates growth inhibition and cytotoxic activity in a variety of leukemias and solid tumors.{22558,22559,22562}
Brand:CaymanSKU:- Clofarabine is a nucleoside analog that inhibits ribonucleotide reductase and DNA polymerase-α (IC50s = 65 and 3.9 nM, respectively) and is cytotoxic to K562 myelogenous leukemia cells (IC50 = 5 nM).{22561} It induces apoptosis in primary chronic lymphocytic leukemia cells by directly altering mitochondrial transmembrane potential.{22560} Clofarabine demonstrates growth inhibition and cytotoxic activity in a variety of leukemias and solid tumors.{22558,22559,22562}
Brand:CaymanSKU:- Clofarabine is a nucleoside analog that inhibits ribonucleotide reductase and DNA polymerase-α (IC50s = 65 and 3.9 nM, respectively) and is cytotoxic to K562 myelogenous leukemia cells (IC50 = 5 nM).{22561} It induces apoptosis in primary chronic lymphocytic leukemia cells by directly altering mitochondrial transmembrane potential.{22560} Clofarabine demonstrates growth inhibition and cytotoxic activity in a variety of leukemias and solid tumors.{22558,22559,22562}
Brand:CaymanSKU:-
Clofazimine is an antimycobacterial compound with MICs ranging from 0.03 to 0.12 μg/ml against clinical isolates of M. paratuberculosis.{36183} It also has activity against 80 isolates of M. fortuitum, M. chelonae, and M. fallax (MICs = ≤0.25-8 μg/ml).{36184} Clofazimine (25 mg/kg per day) reduces the number of M. tuberculosis infected cells in the spleen and lungs of mice infected with the multidrug-resistant clinical isolate strain CNL.{36185} Formulations containing clofazimine have been used for the treatment of leprosy and drug-resistant tuberculosis.
Brand:CaymanSKU:23301 - 1 gAvailable on backorder
Clofazimine is an antimycobacterial compound with MICs ranging from 0.03 to 0.12 μg/ml against clinical isolates of M. paratuberculosis.{36183} It also has activity against 80 isolates of M. fortuitum, M. chelonae, and M. fallax (MICs = ≤0.25-8 μg/ml).{36184} Clofazimine (25 mg/kg per day) reduces the number of M. tuberculosis infected cells in the spleen and lungs of mice infected with the multidrug-resistant clinical isolate strain CNL.{36185} Formulations containing clofazimine have been used for the treatment of leprosy and drug-resistant tuberculosis.
Brand:CaymanSKU:23301 - 10 gAvailable on backorder
Clofazimine is an antimycobacterial compound with MICs ranging from 0.03 to 0.12 μg/ml against clinical isolates of M. paratuberculosis.{36183} It also has activity against 80 isolates of M. fortuitum, M. chelonae, and M. fallax (MICs = ≤0.25-8 μg/ml).{36184} Clofazimine (25 mg/kg per day) reduces the number of M. tuberculosis infected cells in the spleen and lungs of mice infected with the multidrug-resistant clinical isolate strain CNL.{36185} Formulations containing clofazimine have been used for the treatment of leprosy and drug-resistant tuberculosis.
Brand:CaymanSKU:23301 - 5 gAvailable on backorder
Clofentezine is an acaricide that has broad-spectrum activity against various plant-feeding mite species, including those of the genera Panonychus and Tetranchus.{43285} It lethal to wild-type, but not chitin synthase 1 (chs1) mutant, T. urticae mite eggs (LC50s = 1.2 and >5,000 mg/L, respectively). In vivo, clofentezine (13-1,000 mg/kg per day) induces formation of thyroid tumors in male rats.{42197} Formulations containing clofentezine have been used to control mite populations in agriculture.
Brand:CaymanSKU:24228 - 100 mgAvailable on backorder
Clofentezine is an acaricide that has broad-spectrum activity against various plant-feeding mite species, including those of the genera Panonychus and Tetranchus.{43285} It lethal to wild-type, but not chitin synthase 1 (chs1) mutant, T. urticae mite eggs (LC50s = 1.2 and >5,000 mg/L, respectively). In vivo, clofentezine (13-1,000 mg/kg per day) induces formation of thyroid tumors in male rats.{42197} Formulations containing clofentezine have been used to control mite populations in agriculture.
Brand:CaymanSKU:24228 - 25 mgAvailable on backorder
Clofentezine is an acaricide that has broad-spectrum activity against various plant-feeding mite species, including those of the genera Panonychus and Tetranchus.{43285} It lethal to wild-type, but not chitin synthase 1 (chs1) mutant, T. urticae mite eggs (LC50s = 1.2 and >5,000 mg/L, respectively). In vivo, clofentezine (13-1,000 mg/kg per day) induces formation of thyroid tumors in male rats.{42197} Formulations containing clofentezine have been used to control mite populations in agriculture.
Brand:CaymanSKU:24228 - 50 mgAvailable on backorder
Clofibrate is a selective agonist of peroxisome proliferator-activated receptor α (PPARα).{10670} In a transactivation assay, clofibrate exhibits EC50 values of 50 and 55 µM for murine and human PPARα, respectively. It also binds to PPARγ but with 10-fold less affinity and is inactive at PPARδ at concentrations up to 100 µM. Formulations containing clofibrate have been used to treat dyslipidemia and cardiovascular disease.
Brand:CaymanSKU:10956 - 1 gAvailable on backorder
Clofibrate is a selective agonist of peroxisome proliferator-activated receptor α (PPARα).{10670} In a transactivation assay, clofibrate exhibits EC50 values of 50 and 55 µM for murine and human PPARα, respectively. It also binds to PPARγ but with 10-fold less affinity and is inactive at PPARδ at concentrations up to 100 µM. Formulations containing clofibrate have been used to treat dyslipidemia and cardiovascular disease.
Brand:CaymanSKU:10956 - 10 gAvailable on backorder
Clofibrate is a selective agonist of peroxisome proliferator-activated receptor α (PPARα).{10670} In a transactivation assay, clofibrate exhibits EC50 values of 50 and 55 µM for murine and human PPARα, respectively. It also binds to PPARγ but with 10-fold less affinity and is inactive at PPARδ at concentrations up to 100 µM. Formulations containing clofibrate have been used to treat dyslipidemia and cardiovascular disease.
Brand:CaymanSKU:10956 - 5 gAvailable on backorder
Clofibrate is a selective agonist of peroxisome proliferator-activated receptor α (PPARα).{10670} In a transactivation assay, clofibrate exhibits EC50 values of 50 and 55 µM for murine and human PPARα, respectively. It also binds to PPARγ but with 10-fold less affinity and is inactive at PPARδ at concentrations up to 100 µM. Formulations containing clofibrate have been used to treat dyslipidemia and cardiovascular disease.
Brand:CaymanSKU:10956 - 500 mgAvailable on backorder
Clofibric acid is an agonist of peroxisome proliferator-activated receptor α (PPARα). It induces CYP4A6 expression via PPARα activation in RK13 rabbit kidney cells, with an EC50 value of 80 µM.{37343} Clofibric acid also induces carbonyl reductase and bifunctional enzyme expression in the OVCAR-3 human ovarian cell line at a concentration of 500 µM, and decreases OVCAR-3 xenograft tumor growth and vascularity in a mouse OVCAR-3 xenograft model when used as a dietary supplement.{37344} Subcutaneous injection of clofibric acid (200 mg/kg) induces the Δ6 desaturation of linoleic acid to 6,9,12-octadecatrienoic acid, and dietary supplementation with 0.5% (w/w) significantly enhances microsomal steroyl-CoA desaturase activity in rat liver.{37342},{37341} In carp, exposure to 20 mg/L clofibric acid in water increases the expression of several known PPARα target genes and enhances acyl-CoA oxidase activity.{37340}
Brand:CaymanSKU:21608 -Out of stock
Clofibric acid is an agonist of peroxisome proliferator-activated receptor α (PPARα). It induces CYP4A6 expression via PPARα activation in RK13 rabbit kidney cells, with an EC50 value of 80 µM.{37343} Clofibric acid also induces carbonyl reductase and bifunctional enzyme expression in the OVCAR-3 human ovarian cell line at a concentration of 500 µM, and decreases OVCAR-3 xenograft tumor growth and vascularity in a mouse OVCAR-3 xenograft model when used as a dietary supplement.{37344} Subcutaneous injection of clofibric acid (200 mg/kg) induces the Δ6 desaturation of linoleic acid to 6,9,12-octadecatrienoic acid, and dietary supplementation with 0.5% (w/w) significantly enhances microsomal steroyl-CoA desaturase activity in rat liver.{37342},{37341} In carp, exposure to 20 mg/L clofibric acid in water increases the expression of several known PPARα target genes and enhances acyl-CoA oxidase activity.{37340}
Brand:CaymanSKU:21608 -Out of stock
Clomazone is an herbicide that reduces chlorophyll and carotenoid levels in plants.{38322} It is used to control grasses and broad-leaved weeds but is toxic to certain aquatic wildlife with an LC50 of 7.32 mg/L for silver catfish.{38323} It decreases acetylcholinesterase (AChE) activity in brain and muscle tissue of the silver catfish (83 and 89% inhibition, respectively) when used at concentrations of 5, 10, and 20 mg/L. However, it increases AChE activity in muscle of the teleost fish.{38324}
Brand:CaymanSKU:23298 - 100 mgAvailable on backorder
Clomazone is an herbicide that reduces chlorophyll and carotenoid levels in plants.{38322} It is used to control grasses and broad-leaved weeds but is toxic to certain aquatic wildlife with an LC50 of 7.32 mg/L for silver catfish.{38323} It decreases acetylcholinesterase (AChE) activity in brain and muscle tissue of the silver catfish (83 and 89% inhibition, respectively) when used at concentrations of 5, 10, and 20 mg/L. However, it increases AChE activity in muscle of the teleost fish.{38324}
Brand:CaymanSKU:23298 - 50 mgAvailable on backorder
Clomiphene is a selective estrogen receptor modulator that impairs the activation of estrogen receptors (ERs) by 17β-estradiol.{23588,23594} It potently binds both ERα and ERβ (Ki = 0.9 and 1.2 nM, respectively).{23592} Clomiphene enhances the release of gonadotropin-releasing hormone, stimulating the release of follicle-stimulating hormone and luteinizing hormone, culminating in ovulation.{23591,23588}
Brand:CaymanSKU:- Clomiphene is a selective estrogen receptor modulator that impairs the activation of estrogen receptors (ERs) by 17β-estradiol.{23588,23594} It potently binds both ERα and ERβ (Ki = 0.9 and 1.2 nM, respectively).{23592} Clomiphene enhances the release of gonadotropin-releasing hormone, stimulating the release of follicle-stimulating hormone and luteinizing hormone, culminating in ovulation.{23591,23588}
Brand:CaymanSKU:- Clomiphene is a selective estrogen receptor modulator that impairs the activation of estrogen receptors (ERs) by 17β-estradiol.{23588,23594} It potently binds both ERα and ERβ (Ki = 0.9 and 1.2 nM, respectively).{23592} Clomiphene enhances the release of gonadotropin-releasing hormone, stimulating the release of follicle-stimulating hormone and luteinizing hormone, culminating in ovulation.{23591,23588}
Brand:CaymanSKU:- Clomiphene is a selective estrogen receptor modulator that impairs the activation of estrogen receptors (ERs) by 17β-estradiol.{23588,23594} It potently binds both ERα and ERβ (Ki = 0.9 and 1.2 nM, respectively).{23592} Clomiphene enhances the release of gonadotropin-releasing hormone, stimulating the release of follicle-stimulating hormone and luteinizing hormone, culminating in ovulation.{23591,23588}
Brand:CaymanSKU:-
Clomipramine is a tricyclic antidepressant, the 3-chlorinated derivative of imipramine (Item No. 15890).{25873} Like imipramine, clomipramine potently inhibits serotonin and norepinephrine reuptake (Kis = 7.4 and 96 nM, respectively).{25680,22877} It also is an antagonist at histamine, muscarinic acetylcholine, α1-adrenergic, and dopamine receptors (Kds = 31, 37, 38, and 190 nM for H1, M1, α1, and D2, respectively).{25914}
Brand:CaymanSKU:-
Clomipramine-d3 (hydrochloride) (Item No. 15803) is intended for use as an internal standard for the quantification of clomipramine (Item No. 15884) by GC- or LC-MS. Clomipramine is categorized as a tricyclic antidepressant.{25873} This product is intended for research and forensic applications.
Brand:CaymanSKU:- Clomipramine-d3 (hydrochloride) (Item No. 15803) is intended for use as an internal standard for the quantification of clomipramine (Item No. 15884) by GC- or LC-MS. Clomipramine is categorized as a tricyclic antidepressant.{25873} This product is intended for research and forensic applications.
Brand:CaymanSKU:-
Clonidine is an agonist of α2-adrenergic receptors (α2-ARs; Kis = 61.66, 69.18, and 134.9 nM for α2A-, α2B-, and α2C-ARs, respectively).{40326} It stimulates [35S]GTPγS binding to HEK293 cell membranes expressing the human receptors with EC50 values of 26.92, 56.23, and 912.01 nM for α2A-, α2B-, and α2C-ARs, respectively. Clonidine also binds to I1-imidazoline sites in a variety of cell and tissue types (Kds = 4-15 nM).{46373} It induces relaxation of isolated mesenteric artery rings precontracted with norepinephrine (Item No. 16673) when used at a concentration of 10 μM.{25849} Clonidine (10 μM) also induces membrane hyperpolarization and reduces norepinephrine-induced depolarization in isolated mesenteric artery rings. Clonidine (0.1 and 1 μg/kg) reduces mean blood pressure and heart rate when administered via microinjection to the nucleus reticularis lateralis (NRL) of anesthetized normotensive cats.{36359} Formulations containing clonidine have been used in the treatment of hypertension.
Brand:CaymanSKU:- Clonidine is an agonist of α2-adrenergic receptors (α2-ARs; Kis = 61.66, 69.18, and 134.9 nM for α2A-, α2B-, and α2C-ARs, respectively).{40326} It stimulates [35S]GTPγS binding to HEK293 cell membranes expressing the human receptors with EC50 values of 26.92, 56.23, and 912.01 nM for α2A-, α2B-, and α2C-ARs, respectively. Clonidine also binds to I1-imidazoline sites in a variety of cell and tissue types (Kds = 4-15 nM).{46373} It induces relaxation of isolated mesenteric artery rings precontracted with norepinephrine (Item No. 16673) when used at a concentration of 10 μM.{25849} Clonidine (10 μM) also induces membrane hyperpolarization and reduces norepinephrine-induced depolarization in isolated mesenteric artery rings. Clonidine (0.1 and 1 μg/kg) reduces mean blood pressure and heart rate when administered via microinjection to the nucleus reticularis lateralis (NRL) of anesthetized normotensive cats.{36359} Formulations containing clonidine have been used in the treatment of hypertension.
Brand:CaymanSKU:- Clonidine is an agonist of α2-adrenergic receptors (α2-ARs; Kis = 61.66, 69.18, and 134.9 nM for α2A-, α2B-, and α2C-ARs, respectively).{40326} It stimulates [35S]GTPγS binding to HEK293 cell membranes expressing the human receptors with EC50 values of 26.92, 56.23, and 912.01 nM for α2A-, α2B-, and α2C-ARs, respectively. Clonidine also binds to I1-imidazoline sites in a variety of cell and tissue types (Kds = 4-15 nM).{46373} It induces relaxation of isolated mesenteric artery rings precontracted with norepinephrine (Item No. 16673) when used at a concentration of 10 μM.{25849} Clonidine (10 μM) also induces membrane hyperpolarization and reduces norepinephrine-induced depolarization in isolated mesenteric artery rings. Clonidine (0.1 and 1 μg/kg) reduces mean blood pressure and heart rate when administered via microinjection to the nucleus reticularis lateralis (NRL) of anesthetized normotensive cats.{36359} Formulations containing clonidine have been used in the treatment of hypertension.
Brand:CaymanSKU:-
Clonidine-d4 is intended for use as an internal standard for the quantification of clonidine (Item No. 15949) by GC- or LC-MS. Clonidine is an agonist of α2-adrenergic receptors (α2-ARs; Kis = 61.66, 69.18, and 134.9 nM for α2A-, α2B-, and α2C-ARs, respectively).{40326} It stimulates [35S]GTPγS binding to HEK293 cell membranes expressing the human receptors with EC50 values of 26.92, 56.23, and 912.01 nM for α2A-, α2B-, and α2C-ARs, respectively. Clonidine also binds to I1-imidazoline sites in a variety of cell and tissue types (Kds = 4-15 nM).{46373} It induces relaxation of isolated mesenteric artery rings precontracted with norepinephrine (Item No. 16673) when used at a concentration of 10 μM.{25849} Clonidine (10 μM) also induces membrane hyperpolarization and reduces norepinephrine-induced depolarization in isolated mesenteric artery rings. Clonidine (0.1 and 1 μg/kg) reduces mean blood pressure and heart rate when administered via microinjection to the nucleus reticularis lateralis (NRL) of anesthetized normotensive cats.{36359} Formulations containing clonidine have been used in the treatment of hypertension.
Brand:CaymanSKU:28519 - 2.5 mgAvailable on backorder
Cloniprazepam (Item No. 23106) is an analytical reference standard categorized as a benzodiazepine.{35230} It has been detected in illicit tablets. This product is intended for research and forensic applications.
Brand:CaymanSKU:23106 - 1 mgAvailable on backorder
Cloniprazepam (Item No. 23106) is an analytical reference standard categorized as a benzodiazepine.{35230} It has been detected in illicit tablets. This product is intended for research and forensic applications.
Brand:CaymanSKU:23106 - 5 mgAvailable on backorder
Clonixin is a non-steroidal anti-inflammatory drug (NSAID). It induces analgesia in rats in the formalin test when administered at doses of 80 and 120 mg/kg.{43843} It also inhibits paw edema induced by carrageenan in rats, as well as decreases vascular permeability and acts as an antipyretic in mice.{43844}
Brand:CaymanSKU:22284 -Out of stock
Clonixin is a non-steroidal anti-inflammatory drug (NSAID). It induces analgesia in rats in the formalin test when administered at doses of 80 and 120 mg/kg.{43843} It also inhibits paw edema induced by carrageenan in rats, as well as decreases vascular permeability and acts as an antipyretic in mice.{43844}
Brand:CaymanSKU:22284 -Out of stock
Clonixin is a non-steroidal anti-inflammatory drug (NSAID). It induces analgesia in rats in the formalin test when administered at doses of 80 and 120 mg/kg.{43843} It also inhibits paw edema induced by carrageenan in rats, as well as decreases vascular permeability and acts as an antipyretic in mice.{43844}
Brand:CaymanSKU:22284 -Out of stock
Clonixin is a non-steroidal anti-inflammatory drug (NSAID). It induces analgesia in rats in the formalin test when administered at doses of 80 and 120 mg/kg.{43843} It also inhibits paw edema induced by carrageenan in rats, as well as decreases vascular permeability and acts as an antipyretic in mice.{43844}
Brand:CaymanSKU:22284 -Out of stock
Clonostachydiol is a fungal metabolite originally isolated from Clonostachys cylindrospora that has anticancer and anthelmintic activities.{46835,46836} It is cytotoxic to P388 (IC50 = 25 µM), as well as L1210, HT-29, and A549 cancer cells (IC50s = 4.5, 4.2, and 5.7 µg/ml, respectively). Clonostachydiol (2.5 mg/kg, s.c.) reduces fecal worm burden by 80 to 90% in lambs infected with the nematode H. contortus.{46835}
Brand:CaymanSKU:29066 - 1 mgAvailable on backorder
Clopamide is a thiazide-like diuretic that inhibits sodium/chloride cotransporters in the proximal convoluted tubule of the kidney, which prevents the reabsorption of sodium and chloride.{30826,30827} This compound is intended for research purposes only.
Brand:CaymanSKU:-Available on backorder
Clopidogrel (Item No. 13657) is an antithrombic compound whose active metabolite is a selective, irreversible antagonist of the platelet purinergic P2Y12 receptor (IC50 = 100 nM).{19256,19258} Clopidogrel inhibits ADP-induced platelet aggregation ex vivo and functions as a prodrug whereupon biotransformation to its active thiol metabolite via CYP2C19 in the liver enables its anti-aggregating activity.{19259} An estimated 15% of administered clopidogrel is metabolized by CYP2C19 to the thiol metabolite.{29027} Clopidogrel carboxylic acid is a major inactive metabolite of clopidogrel. Most (85%) of circulating clopidogrel is hydrolyzed by esterases to this carboxylic acid form.{29027} This inactive metabolite can be used as a reference standard for quantitative analysis of clopidogrel metabolism.{29028}
Brand:CaymanSKU:-Available on backorder