Cayman
Showing 15301–15450 of 45550 results
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Chrysophanol is an anthraquinone that has been found in R. palmatum and has diverse biological activities.{31786,31785,31784} It induces necrosis in J5 human liver cancer cells when used at concentrations of 25, 50, 75, 100, and 200 µM.{31785} Chrysophanol (5, 10, and 50 µM) reduces LPS-induced production of nitric oxide (NO) and prostaglandin E2 (PGE2; Item No. 14010) and inhibits LPS-induced DNA oxidation in BV-2 microglia.{31784} In vivo, chrysophanol (5 mg/kg) decreases colonic levels of IL-6 and activation of NF-κB and reduces weight loss, diarrhea, and rectal bleeding in a mouse model of colitis induced by dextran sulfate (DSS; Item No. 23250).{59380} Chrysophanol (0.1, 1, and 10 mg/kg) increases survival, reduces brain tissue loss, and ameliorates motor balance deficits in a mouse model of ischemia-reperfusion injury induced by middle cerebral artery occlusion (MCAO).{59381}
Brand:CaymanSKU:19870 -Available on backorder
Chrysophanol is an anthraquinone that has been found in R. palmatum and has diverse biological activities.{31786,31785,31784} It induces necrosis in J5 human liver cancer cells when used at concentrations of 25, 50, 75, 100, and 200 µM.{31785} Chrysophanol (5, 10, and 50 µM) reduces LPS-induced production of nitric oxide (NO) and prostaglandin E2 (PGE2; Item No. 14010) and inhibits LPS-induced DNA oxidation in BV-2 microglia.{31784} In vivo, chrysophanol (5 mg/kg) decreases colonic levels of IL-6 and activation of NF-κB and reduces weight loss, diarrhea, and rectal bleeding in a mouse model of colitis induced by dextran sulfate (DSS; Item No. 23250).{59380} Chrysophanol (0.1, 1, and 10 mg/kg) increases survival, reduces brain tissue loss, and ameliorates motor balance deficits in a mouse model of ischemia-reperfusion injury induced by middle cerebral artery occlusion (MCAO).{59381}
Brand:CaymanSKU:19870 -Available on backorder
Chrysophanol is an anthraquinone that has been found in R. palmatum and has diverse biological activities.{31786,31785,31784} It induces necrosis in J5 human liver cancer cells when used at concentrations of 25, 50, 75, 100, and 200 µM.{31785} Chrysophanol (5, 10, and 50 µM) reduces LPS-induced production of nitric oxide (NO) and prostaglandin E2 (PGE2; Item No. 14010) and inhibits LPS-induced DNA oxidation in BV-2 microglia.{31784} In vivo, chrysophanol (5 mg/kg) decreases colonic levels of IL-6 and activation of NF-κB and reduces weight loss, diarrhea, and rectal bleeding in a mouse model of colitis induced by dextran sulfate (DSS; Item No. 23250).{59380} Chrysophanol (0.1, 1, and 10 mg/kg) increases survival, reduces brain tissue loss, and ameliorates motor balance deficits in a mouse model of ischemia-reperfusion injury induced by middle cerebral artery occlusion (MCAO).{59381}
Brand:CaymanSKU:19870 -Available on backorder
Chrysosplenetin is a flavonoid that has been found in A. annua and has diverse biological activities.{57215,57216,57217} It is active against P. falciparum in vitro (IC50 = 23 µM).{57215} Chrysosplenetin inhibits the cytopathic effect of enterovirus 71 (EV71) in Vero cells (EC50 = 0.68 µM) and increases survival in a neonatal mouse model of EV71 infection when administered at doses of 1 and 5 mg/kg.{57216} It also increases proliferation and osteogenic differentiation of isolated human bone marrow stromal cells (BMSCs) and prevents estrogen deficiency-induced bone loss in ovariectomized mice.{57217}
Brand:CaymanSKU:30625 - 1 mgAvailable on backorder
Chrysosplenetin is a flavonoid that has been found in A. annua and has diverse biological activities.{57215,57216,57217} It is active against P. falciparum in vitro (IC50 = 23 µM).{57215} Chrysosplenetin inhibits the cytopathic effect of enterovirus 71 (EV71) in Vero cells (EC50 = 0.68 µM) and increases survival in a neonatal mouse model of EV71 infection when administered at doses of 1 and 5 mg/kg.{57216} It also increases proliferation and osteogenic differentiation of isolated human bone marrow stromal cells (BMSCs) and prevents estrogen deficiency-induced bone loss in ovariectomized mice.{57217}
Brand:CaymanSKU:30625 - 10 mgAvailable on backorder
Chrysosplenetin is a flavonoid that has been found in A. annua and has diverse biological activities.{57215,57216,57217} It is active against P. falciparum in vitro (IC50 = 23 µM).{57215} Chrysosplenetin inhibits the cytopathic effect of enterovirus 71 (EV71) in Vero cells (EC50 = 0.68 µM) and increases survival in a neonatal mouse model of EV71 infection when administered at doses of 1 and 5 mg/kg.{57216} It also increases proliferation and osteogenic differentiation of isolated human bone marrow stromal cells (BMSCs) and prevents estrogen deficiency-induced bone loss in ovariectomized mice.{57217}
Brand:CaymanSKU:30625 - 5 mgAvailable on backorder
CHS-828 is a pyridyl cyanoguanidine anti-tumor agent that has been identified as a competitive inhibitor of Nampt as well as an inhibitor of NF-κB pathway activity.{20745,20747} CHS-828 has potent cytotoxic effects in human breast (IC50 = 7.3 nM) and lung cancer (IC50 = 0.5 nM) cells both in vitro and in vivo.{20744} In nude mice bearing human tumor xenografts, CHS-828, at 20-50 mg/kg/day, inhibits the growth of MCF-7 breast cancer tumors and induces regression of NYH small cell lung cancer tumors.{20744}
Brand:CaymanSKU:11021 - 10 mgAvailable on backorder
CHS-828 is a pyridyl cyanoguanidine anti-tumor agent that has been identified as a competitive inhibitor of Nampt as well as an inhibitor of NF-κB pathway activity.{20745,20747} CHS-828 has potent cytotoxic effects in human breast (IC50 = 7.3 nM) and lung cancer (IC50 = 0.5 nM) cells both in vitro and in vivo.{20744} In nude mice bearing human tumor xenografts, CHS-828, at 20-50 mg/kg/day, inhibits the growth of MCF-7 breast cancer tumors and induces regression of NYH small cell lung cancer tumors.{20744}
Brand:CaymanSKU:11021 - 25 mgAvailable on backorder
CHS-828 is a pyridyl cyanoguanidine anti-tumor agent that has been identified as a competitive inhibitor of Nampt as well as an inhibitor of NF-κB pathway activity.{20745,20747} CHS-828 has potent cytotoxic effects in human breast (IC50 = 7.3 nM) and lung cancer (IC50 = 0.5 nM) cells both in vitro and in vivo.{20744} In nude mice bearing human tumor xenografts, CHS-828, at 20-50 mg/kg/day, inhibits the growth of MCF-7 breast cancer tumors and induces regression of NYH small cell lung cancer tumors.{20744}
Brand:CaymanSKU:11021 - 5 mgAvailable on backorder
CHS-828 is a pyridyl cyanoguanidine anti-tumor agent that has been identified as a competitive inhibitor of Nampt as well as an inhibitor of NF-κB pathway activity.{20745,20747} CHS-828 has potent cytotoxic effects in human breast (IC50 = 7.3 nM) and lung cancer (IC50 = 0.5 nM) cells both in vitro and in vivo.{20744} In nude mice bearing human tumor xenografts, CHS-828, at 20-50 mg/kg/day, inhibits the growth of MCF-7 breast cancer tumors and induces regression of NYH small cell lung cancer tumors.{20744}
Brand:CaymanSKU:11021 - 50 mgAvailable on backorder
Chymostatin is a bioactive peptide of microbial origin that acts as a protease inhibitor with selectivity for chymotryptase-like serine proteases.{24067} It potently inhibits chymotrypsin and chymase (Ki = 9.36 and 13.1 nM, respectively) while less effectively blocking the activity of cathepsins, papain, and leukocyte elastase.{24069,24067,24065,24068,24066} It is without effect on trypsin, thrombin, plasmin, pepsin, and kallikrein.{24067}
Brand:CaymanSKU:- Chymostatin is a bioactive peptide of microbial origin that acts as a protease inhibitor with selectivity for chymotryptase-like serine proteases.{24067} It potently inhibits chymotrypsin and chymase (Ki = 9.36 and 13.1 nM, respectively) while less effectively blocking the activity of cathepsins, papain, and leukocyte elastase.{24069,24067,24065,24068,24066} It is without effect on trypsin, thrombin, plasmin, pepsin, and kallikrein.{24067}
Brand:CaymanSKU:- Chymostatin is a bioactive peptide of microbial origin that acts as a protease inhibitor with selectivity for chymotryptase-like serine proteases.{24067} It potently inhibits chymotrypsin and chymase (Ki = 9.36 and 13.1 nM, respectively) while less effectively blocking the activity of cathepsins, papain, and leukocyte elastase.{24069,24067,24065,24068,24066} It is without effect on trypsin, thrombin, plasmin, pepsin, and kallikrein.{24067}
Brand:CaymanSKU:- Chymostatin is a bioactive peptide of microbial origin that acts as a protease inhibitor with selectivity for chymotryptase-like serine proteases.{24067} It potently inhibits chymotrypsin and chymase (Ki = 9.36 and 13.1 nM, respectively) while less effectively blocking the activity of cathepsins, papain, and leukocyte elastase.{24069,24067,24065,24068,24066} It is without effect on trypsin, thrombin, plasmin, pepsin, and kallikrein.{24067}
Brand:CaymanSKU:-
The dual specific threonine/tyrosine kinase, map kinase kinase (MEK), is a key component of the RAS/RAF/MEK/ERK signaling pathway that is frequently activated in human tumors.{6694,16830} CI-1040 is a benzhydroxamate compound that potently inhibits MEK in an in vitro mitogen-activated protein kinase cascade assay with an IC50 value of 2.3 nM (Kd = 74 nM when activated with adenosine triphosphate).{16877,15629} It can suppress phosphorylation of ERK in mouse colon 26 tumors with an IC50 value of 35 nM and demonstrates in vivo activity with oral administration in a mouse tumor model.{16877} The second-generation MEK inhibitor PD 0325901 (Item No. 13034) is a structural derivative of CI-1040 that was developed for improved solubility.{16877}
Brand:CaymanSKU:11580 - 10 mgAvailable on backorder
The dual specific threonine/tyrosine kinase, map kinase kinase (MEK), is a key component of the RAS/RAF/MEK/ERK signaling pathway that is frequently activated in human tumors.{6694,16830} CI-1040 is a benzhydroxamate compound that potently inhibits MEK in an in vitro mitogen-activated protein kinase cascade assay with an IC50 value of 2.3 nM (Kd = 74 nM when activated with adenosine triphosphate).{16877,15629} It can suppress phosphorylation of ERK in mouse colon 26 tumors with an IC50 value of 35 nM and demonstrates in vivo activity with oral administration in a mouse tumor model.{16877} The second-generation MEK inhibitor PD 0325901 (Item No. 13034) is a structural derivative of CI-1040 that was developed for improved solubility.{16877}
Brand:CaymanSKU:11580 - 25 mgAvailable on backorder
The dual specific threonine/tyrosine kinase, map kinase kinase (MEK), is a key component of the RAS/RAF/MEK/ERK signaling pathway that is frequently activated in human tumors.{6694,16830} CI-1040 is a benzhydroxamate compound that potently inhibits MEK in an in vitro mitogen-activated protein kinase cascade assay with an IC50 value of 2.3 nM (Kd = 74 nM when activated with adenosine triphosphate).{16877,15629} It can suppress phosphorylation of ERK in mouse colon 26 tumors with an IC50 value of 35 nM and demonstrates in vivo activity with oral administration in a mouse tumor model.{16877} The second-generation MEK inhibitor PD 0325901 (Item No. 13034) is a structural derivative of CI-1040 that was developed for improved solubility.{16877}
Brand:CaymanSKU:11580 - 5 mgAvailable on backorder
The dual specific threonine/tyrosine kinase, map kinase kinase (MEK), is a key component of the RAS/RAF/MEK/ERK signaling pathway that is frequently activated in human tumors.{6694,16830} CI-1040 is a benzhydroxamate compound that potently inhibits MEK in an in vitro mitogen-activated protein kinase cascade assay with an IC50 value of 2.3 nM (Kd = 74 nM when activated with adenosine triphosphate).{16877,15629} It can suppress phosphorylation of ERK in mouse colon 26 tumors with an IC50 value of 35 nM and demonstrates in vivo activity with oral administration in a mouse tumor model.{16877} The second-generation MEK inhibitor PD 0325901 (Item No. 13034) is a structural derivative of CI-1040 that was developed for improved solubility.{16877}
Brand:CaymanSKU:11580 - 50 mgAvailable on backorder
Acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT-1) is a sterol O-acyltransferase that catalyzes the formation of fatty acid-cholesterol esters, an important step in lipoprotein assembly and dietary cholesterol absorption.{12931,12021} CI-976 is a potent, selective inhibitor of ACAT-1 (IC50 = 73 nM).{28323,28321} It is orally bioavailable and decreases plasma total cholesterol, very low density lipoprotein (VLDL) cholesterol, LDL cholesterol, apolipoprotein B, liver cholesteryl esters, and VLDL and LDL cholesteryl ester content in rabbits given a diet that induces hypercholesterolemia.{28322} CI-976 also diminishes atherosclerotic activity in hypercholesterolemic rabbits.{28324}
Brand:CaymanSKU:-Out of stock
Acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT-1) is a sterol O-acyltransferase that catalyzes the formation of fatty acid-cholesterol esters, an important step in lipoprotein assembly and dietary cholesterol absorption.{12931,12021} CI-976 is a potent, selective inhibitor of ACAT-1 (IC50 = 73 nM).{28323,28321} It is orally bioavailable and decreases plasma total cholesterol, very low density lipoprotein (VLDL) cholesterol, LDL cholesterol, apolipoprotein B, liver cholesteryl esters, and VLDL and LDL cholesteryl ester content in rabbits given a diet that induces hypercholesterolemia.{28322} CI-976 also diminishes atherosclerotic activity in hypercholesterolemic rabbits.{28324}
Brand:CaymanSKU:-Out of stock
Acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT-1) is a sterol O-acyltransferase that catalyzes the formation of fatty acid-cholesterol esters, an important step in lipoprotein assembly and dietary cholesterol absorption.{12931,12021} CI-976 is a potent, selective inhibitor of ACAT-1 (IC50 = 73 nM).{28323,28321} It is orally bioavailable and decreases plasma total cholesterol, very low density lipoprotein (VLDL) cholesterol, LDL cholesterol, apolipoprotein B, liver cholesteryl esters, and VLDL and LDL cholesteryl ester content in rabbits given a diet that induces hypercholesterolemia.{28322} CI-976 also diminishes atherosclerotic activity in hypercholesterolemic rabbits.{28324}
Brand:CaymanSKU:-Out of stock
Acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT-1) is a sterol O-acyltransferase that catalyzes the formation of fatty acid-cholesterol esters, an important step in lipoprotein assembly and dietary cholesterol absorption.{12931,12021} CI-976 is a potent, selective inhibitor of ACAT-1 (IC50 = 73 nM).{28323,28321} It is orally bioavailable and decreases plasma total cholesterol, very low density lipoprotein (VLDL) cholesterol, LDL cholesterol, apolipoprotein B, liver cholesteryl esters, and VLDL and LDL cholesteryl ester content in rabbits given a diet that induces hypercholesterolemia.{28322} CI-976 also diminishes atherosclerotic activity in hypercholesterolemic rabbits.{28324}
Brand:CaymanSKU:-Out of stock
CI-994 is an inhibitor of class I HDACs displaying IC50 values of 0.9, 0.9, 1.2, and >20 μM when screened in vitro against recombinant human HDAC 1, 2, 3, and 8, respectively.{21578} CI-994 has a wide spectrum of antitumor activity, particularly in tumors normally refractory to conventional anticancer agents, in preclinical models both in vitro and in vivo and has advanced through phase I and II clinical trials in combination therapy treatments.{21576,21577,21579}
Brand:CaymanSKU:12084 - 10 mgAvailable on backorder
CI-994 is an inhibitor of class I HDACs displaying IC50 values of 0.9, 0.9, 1.2, and >20 μM when screened in vitro against recombinant human HDAC 1, 2, 3, and 8, respectively.{21578} CI-994 has a wide spectrum of antitumor activity, particularly in tumors normally refractory to conventional anticancer agents, in preclinical models both in vitro and in vivo and has advanced through phase I and II clinical trials in combination therapy treatments.{21576,21577,21579}
Brand:CaymanSKU:12084 - 5 mgAvailable on backorder
CI-994 is an inhibitor of class I HDACs displaying IC50 values of 0.9, 0.9, 1.2, and >20 μM when screened in vitro against recombinant human HDAC 1, 2, 3, and 8, respectively.{21578} CI-994 has a wide spectrum of antitumor activity, particularly in tumors normally refractory to conventional anticancer agents, in preclinical models both in vitro and in vivo and has advanced through phase I and II clinical trials in combination therapy treatments.{21576,21577,21579}
Brand:CaymanSKU:12084 - 50 mgAvailable on backorder
Prostaglandin I2 (PGI2, prostacyclin) is the most potent endogenous vasodilator that affects both the systemic and pulmonary circulation.{643} Cicaprost is a PGI2 analog that is orally active with prolonged availability in vivo, having a terminal half life in plasma of one hour.{6640}{18554} In addition to their effects on smooth muscle, PGI2 analogs, including cicaprost, have been shown to inhibit the pro-inflammatory actions of certain leukocytes, suppress cardiac fibrosis, and block mitogenesis of certain cell types.{18547}{18548}{18546} Importantly, cicaprost has been shown to strongly reduce lung and lymph node metastasis in rats, suggesting that it might be useful in cancer therapy.{19177}
Brand:CaymanSKU:-Out of stock
Prostaglandin I2 (PGI2, prostacyclin) is the most potent endogenous vasodilator that affects both the systemic and pulmonary circulation.{643} Cicaprost is a PGI2 analog that is orally active with prolonged availability in vivo, having a terminal half life in plasma of one hour.{6640}{18554} In addition to their effects on smooth muscle, PGI2 analogs, including cicaprost, have been shown to inhibit the pro-inflammatory actions of certain leukocytes, suppress cardiac fibrosis, and block mitogenesis of certain cell types.{18547}{18548}{18546} Importantly, cicaprost has been shown to strongly reduce lung and lymph node metastasis in rats, suggesting that it might be useful in cancer therapy.{19177}
Brand:CaymanSKU:-Out of stock
Prostaglandin I2 (PGI2, prostacyclin) is the most potent endogenous vasodilator that affects both the systemic and pulmonary circulation.{643} Cicaprost is a PGI2 analog that is orally active with prolonged availability in vivo, having a terminal half life in plasma of one hour.{6640}{18554} In addition to their effects on smooth muscle, PGI2 analogs, including cicaprost, have been shown to inhibit the pro-inflammatory actions of certain leukocytes, suppress cardiac fibrosis, and block mitogenesis of certain cell types.{18547}{18548}{18546} Importantly, cicaprost has been shown to strongly reduce lung and lymph node metastasis in rats, suggesting that it might be useful in cancer therapy.{19177}
Brand:CaymanSKU:-Out of stock
Ciclesonide (CIC) is a prodrug form of the glucocorticoid receptor agonist desisobutyryl-CIC (des-CIC).{29504} CIC binds to the glucocorticoid receptor with a Ki value of 37 nM.{29502} It is selective for the glucocorticoid receptor over the estrogen, progesterone, and testosterone receptors. CIC inhibits eosinophil influx into the lung (ED50 = 0.49 mg/kg) and reduces sephadex-induced lung edema (ED50 = 0.72 mg/kg) in a rat model of ovalbumin-sensitized and -challenged airway inflammation. Formulations containing CIC have been used in the maintenance treatment of asthma and in the treatment of allergic rhinitis.
Brand:CaymanSKU:-Available on backorder
Ciclesonide (CIC) is a prodrug form of the glucocorticoid receptor agonist desisobutyryl-CIC (des-CIC).{29504} CIC binds to the glucocorticoid receptor with a Ki value of 37 nM.{29502} It is selective for the glucocorticoid receptor over the estrogen, progesterone, and testosterone receptors. CIC inhibits eosinophil influx into the lung (ED50 = 0.49 mg/kg) and reduces sephadex-induced lung edema (ED50 = 0.72 mg/kg) in a rat model of ovalbumin-sensitized and -challenged airway inflammation. Formulations containing CIC have been used in the maintenance treatment of asthma and in the treatment of allergic rhinitis.
Brand:CaymanSKU:-Available on backorder
Ciclesonide (CIC) is a prodrug form of the glucocorticoid receptor agonist desisobutyryl-CIC (des-CIC).{29504} CIC binds to the glucocorticoid receptor with a Ki value of 37 nM.{29502} It is selective for the glucocorticoid receptor over the estrogen, progesterone, and testosterone receptors. CIC inhibits eosinophil influx into the lung (ED50 = 0.49 mg/kg) and reduces sephadex-induced lung edema (ED50 = 0.72 mg/kg) in a rat model of ovalbumin-sensitized and -challenged airway inflammation. Formulations containing CIC have been used in the maintenance treatment of asthma and in the treatment of allergic rhinitis.
Brand:CaymanSKU:-Available on backorder
Ciclesonide (CIC) is a prodrug form of the glucocorticoid receptor agonist desisobutyryl-CIC (des-CIC).{29504} CIC binds to the glucocorticoid receptor with a Ki value of 37 nM.{29502} It is selective for the glucocorticoid receptor over the estrogen, progesterone, and testosterone receptors. CIC inhibits eosinophil influx into the lung (ED50 = 0.49 mg/kg) and reduces sephadex-induced lung edema (ED50 = 0.72 mg/kg) in a rat model of ovalbumin-sensitized and -challenged airway inflammation. Formulations containing CIC have been used in the maintenance treatment of asthma and in the treatment of allergic rhinitis.
Brand:CaymanSKU:-Available on backorder
Ciclesonide-d7 is intended for use as an internal standard for the quantification of ciclesonide (CIC; Item No. 18227) by GC- or LC-MS. Ciclesonide is a prodrug form of the glucocorticoid receptor agonist desisobutyryl-CIC (des-CIC).{29504} CIC binds to the glucocorticoid receptor with a Ki value of 37 nM.{29502} It is selective for the glucocorticoid receptor over the estrogen, progesterone, and testosterone receptors. CIC inhibits eosinophil influx into the lung (ED50 = 0.49 mg/kg) and reduces sephadex-induced lung edema (ED50 = 0.72 mg/kg) in a rat model of ovalbumin-sensitized and -challenged airway inflammation. Formulations containing CIC have been used in the maintenance treatment of asthma and in the treatment of allergic rhinitis.
Brand:CaymanSKU:28527 - 1 mgAvailable on backorder
Ciclesonide-d7 is intended for use as an internal standard for the quantification of ciclesonide (CIC; Item No. 18227) by GC- or LC-MS. Ciclesonide is a prodrug form of the glucocorticoid receptor agonist desisobutyryl-CIC (des-CIC).{29504} CIC binds to the glucocorticoid receptor with a Ki value of 37 nM.{29502} It is selective for the glucocorticoid receptor over the estrogen, progesterone, and testosterone receptors. CIC inhibits eosinophil influx into the lung (ED50 = 0.49 mg/kg) and reduces sephadex-induced lung edema (ED50 = 0.72 mg/kg) in a rat model of ovalbumin-sensitized and -challenged airway inflammation. Formulations containing CIC have been used in the maintenance treatment of asthma and in the treatment of allergic rhinitis.
Brand:CaymanSKU:28527 - 500 µgAvailable on backorder
Ciclopirox is an iron chelator, antifungal, and anticancer agent.{26941,41490,53131,53132} It inhibits the iron-dependent enzyme prolyl hydroxylase 2 (PHD2; IC50 = 1.58 μM), an effect that is reduced in the presence of iron.{26941} It stabilizes hypoxia-inducible factor-α (HIF-1α) under normoxic conditions in rat glomus cells when used at a concentration of 5 μM.{33213} Ciclopirox is active against clinical isolates of T. rubrum, T. mentagrophytes, and C. albicans (MICs = 0.03-0.5, 0.03-0.5, and 0.06-0.5 μg/ml, respectively) and inhibits growth of T. mentagrophytes on porcine skin ex vivo when applied topically.{41490,53131} It inhibits proliferation of Rh30, HT-29, and MDA-MB-231 cells in a concentration-dependent manner and halts the cell cycle at the G1/G0 phase and induces apoptosis in Rh30 cells.{53132} Ciclopirox (25 mg/kg) reduces tumor growth in an MDA-MB-231 mouse xenograft model. Formulations containing ciclopirox have been used in the topical treatment of fungal infections.
Brand:CaymanSKU:- Ciclopirox is an iron chelator, antifungal, and anticancer agent.{26941,41490,53131,53132} It inhibits the iron-dependent enzyme prolyl hydroxylase 2 (PHD2; IC50 = 1.58 μM), an effect that is reduced in the presence of iron.{26941} It stabilizes hypoxia-inducible factor-α (HIF-1α) under normoxic conditions in rat glomus cells when used at a concentration of 5 μM.{33213} Ciclopirox is active against clinical isolates of T. rubrum, T. mentagrophytes, and C. albicans (MICs = 0.03-0.5, 0.03-0.5, and 0.06-0.5 μg/ml, respectively) and inhibits growth of T. mentagrophytes on porcine skin ex vivo when applied topically.{41490,53131} It inhibits proliferation of Rh30, HT-29, and MDA-MB-231 cells in a concentration-dependent manner and halts the cell cycle at the G1/G0 phase and induces apoptosis in Rh30 cells.{53132} Ciclopirox (25 mg/kg) reduces tumor growth in an MDA-MB-231 mouse xenograft model. Formulations containing ciclopirox have been used in the topical treatment of fungal infections.
Brand:CaymanSKU:- Ciclopirox is an iron chelator, antifungal, and anticancer agent.{26941,41490,53131,53132} It inhibits the iron-dependent enzyme prolyl hydroxylase 2 (PHD2; IC50 = 1.58 μM), an effect that is reduced in the presence of iron.{26941} It stabilizes hypoxia-inducible factor-α (HIF-1α) under normoxic conditions in rat glomus cells when used at a concentration of 5 μM.{33213} Ciclopirox is active against clinical isolates of T. rubrum, T. mentagrophytes, and C. albicans (MICs = 0.03-0.5, 0.03-0.5, and 0.06-0.5 μg/ml, respectively) and inhibits growth of T. mentagrophytes on porcine skin ex vivo when applied topically.{41490,53131} It inhibits proliferation of Rh30, HT-29, and MDA-MB-231 cells in a concentration-dependent manner and halts the cell cycle at the G1/G0 phase and induces apoptosis in Rh30 cells.{53132} Ciclopirox (25 mg/kg) reduces tumor growth in an MDA-MB-231 mouse xenograft model. Formulations containing ciclopirox have been used in the topical treatment of fungal infections.
Brand:CaymanSKU:- Ciclopirox is an iron chelator, antifungal, and anticancer agent.{26941,41490,53131,53132} It inhibits the iron-dependent enzyme prolyl hydroxylase 2 (PHD2; IC50 = 1.58 μM), an effect that is reduced in the presence of iron.{26941} It stabilizes hypoxia-inducible factor-α (HIF-1α) under normoxic conditions in rat glomus cells when used at a concentration of 5 μM.{33213} Ciclopirox is active against clinical isolates of T. rubrum, T. mentagrophytes, and C. albicans (MICs = 0.03-0.5, 0.03-0.5, and 0.06-0.5 μg/ml, respectively) and inhibits growth of T. mentagrophytes on porcine skin ex vivo when applied topically.{41490,53131} It inhibits proliferation of Rh30, HT-29, and MDA-MB-231 cells in a concentration-dependent manner and halts the cell cycle at the G1/G0 phase and induces apoptosis in Rh30 cells.{53132} Ciclopirox (25 mg/kg) reduces tumor growth in an MDA-MB-231 mouse xenograft model. Formulations containing ciclopirox have been used in the topical treatment of fungal infections.
Brand:CaymanSKU:-
The Ras family of GTPases, including the Arf, Rho, Ras, and Rab GTPase subfamilies, regulates various cellular processes ranging from membrane trafficking to the control of cell proliferation. They regulate cell physiology by switching between active and inactive conformational states by binding either GTP or GDP. Alterations in GTPase function are a known hallmark of certain cancers and genetic diseases. CID-1067700 is one of the first identified competitive inhibitors of nucleotide binding by Ras-related GTPases.{24538} It binds the nucleotide binding pocket of Rab7 with a Ki value of 13 nM, preventing BODIPY-linked GTP and GDP binding with EC50 values of 11.2 and 21 nM, respectively.{24538}
Brand:CaymanSKU:- The Ras family of GTPases, including the Arf, Rho, Ras, and Rab GTPase subfamilies, regulates various cellular processes ranging from membrane trafficking to the control of cell proliferation. They regulate cell physiology by switching between active and inactive conformational states by binding either GTP or GDP. Alterations in GTPase function are a known hallmark of certain cancers and genetic diseases. CID-1067700 is one of the first identified competitive inhibitors of nucleotide binding by Ras-related GTPases.{24538} It binds the nucleotide binding pocket of Rab7 with a Ki value of 13 nM, preventing BODIPY-linked GTP and GDP binding with EC50 values of 11.2 and 21 nM, respectively.{24538}
Brand:CaymanSKU:- The Ras family of GTPases, including the Arf, Rho, Ras, and Rab GTPase subfamilies, regulates various cellular processes ranging from membrane trafficking to the control of cell proliferation. They regulate cell physiology by switching between active and inactive conformational states by binding either GTP or GDP. Alterations in GTPase function are a known hallmark of certain cancers and genetic diseases. CID-1067700 is one of the first identified competitive inhibitors of nucleotide binding by Ras-related GTPases.{24538} It binds the nucleotide binding pocket of Rab7 with a Ki value of 13 nM, preventing BODIPY-linked GTP and GDP binding with EC50 values of 11.2 and 21 nM, respectively.{24538}
Brand:CaymanSKU:- The Ras family of GTPases, including the Arf, Rho, Ras, and Rab GTPase subfamilies, regulates various cellular processes ranging from membrane trafficking to the control of cell proliferation. They regulate cell physiology by switching between active and inactive conformational states by binding either GTP or GDP. Alterations in GTPase function are a known hallmark of certain cancers and genetic diseases. CID-1067700 is one of the first identified competitive inhibitors of nucleotide binding by Ras-related GTPases.{24538} It binds the nucleotide binding pocket of Rab7 with a Ki value of 13 nM, preventing BODIPY-linked GTP and GDP binding with EC50 values of 11.2 and 21 nM, respectively.{24538}
Brand:CaymanSKU:-
CID-1375606 is a GPR27 agonist with EC50 values of 0.46 µM and 7.9 µM in chimeric GPR27V2 and wild-type GPR27 luciferase β-arrestin-2 complementation assays, respectively.{54081} It is selective for GPR27 over the closely related receptors GPR85 and GPR173 for which it does not induce β-arrestin-2 recruitment in the same assay. GPR27 function has been linked to insulin promoter activity and excretion.{54082}
Brand:CaymanSKU:30422 - 10 mgAvailable on backorder
CID-1375606 is a GPR27 agonist with EC50 values of 0.46 µM and 7.9 µM in chimeric GPR27V2 and wild-type GPR27 luciferase β-arrestin-2 complementation assays, respectively.{54081} It is selective for GPR27 over the closely related receptors GPR85 and GPR173 for which it does not induce β-arrestin-2 recruitment in the same assay. GPR27 function has been linked to insulin promoter activity and excretion.{54082}
Brand:CaymanSKU:30422 - 25 mgAvailable on backorder
CID-1375606 is a GPR27 agonist with EC50 values of 0.46 µM and 7.9 µM in chimeric GPR27V2 and wild-type GPR27 luciferase β-arrestin-2 complementation assays, respectively.{54081} It is selective for GPR27 over the closely related receptors GPR85 and GPR173 for which it does not induce β-arrestin-2 recruitment in the same assay. GPR27 function has been linked to insulin promoter activity and excretion.{54082}
Brand:CaymanSKU:30422 - 5 mgAvailable on backorder
Protein kinase D (PKD) is a serine/threonine protein kinase that is activated by diacylglycerol, commonly downstream of PKC signaling.{13335} The three human PKD isoforms target a variety of proteins to alter cell proliferation, survival, invasion, and protein transport.{13335,25032} CID-2011756 is an inhibitor of all three PKD isoforms (IC50s = 3.2, 0.6, and 0.7 μM for PKD1, PKD2, and PKD3, respectively).{25032} This ATP-competitive inhibitor is cell permeable, blocking the phosphorylation of PKD1 on Ser916 (an autocatalytic target) in LNCaP prostate cancer cells in response to phorbol esters (EC50 = 10 μM).{25032}
Brand:CaymanSKU:- Protein kinase D (PKD) is a serine/threonine protein kinase that is activated by diacylglycerol, commonly downstream of PKC signaling.{13335} The three human PKD isoforms target a variety of proteins to alter cell proliferation, survival, invasion, and protein transport.{13335,25032} CID-2011756 is an inhibitor of all three PKD isoforms (IC50s = 3.2, 0.6, and 0.7 μM for PKD1, PKD2, and PKD3, respectively).{25032} This ATP-competitive inhibitor is cell permeable, blocking the phosphorylation of PKD1 on Ser916 (an autocatalytic target) in LNCaP prostate cancer cells in response to phorbol esters (EC50 = 10 μM).{25032}
Brand:CaymanSKU:- Protein kinase D (PKD) is a serine/threonine protein kinase that is activated by diacylglycerol, commonly downstream of PKC signaling.{13335} The three human PKD isoforms target a variety of proteins to alter cell proliferation, survival, invasion, and protein transport.{13335,25032} CID-2011756 is an inhibitor of all three PKD isoforms (IC50s = 3.2, 0.6, and 0.7 μM for PKD1, PKD2, and PKD3, respectively).{25032} This ATP-competitive inhibitor is cell permeable, blocking the phosphorylation of PKD1 on Ser916 (an autocatalytic target) in LNCaP prostate cancer cells in response to phorbol esters (EC50 = 10 μM).{25032}
Brand:CaymanSKU:-
GPR35 is a G protein-coupled receptor that is activated by kynurenic acid and 2-acyl lysophosphatidic acids (e.g., 2-oleoyl lysophosphatidic acid).{24499,14771,24500} It is expressed predominantly on immune cells, the brain, and in the gastrointestinal tract.{14857,14771} GPR35 is overexpressed in gastric cancer cells.{13309} CID-2745687 is a reversible, competitive antagonist of GPR35, blocking activation by the synthetic agonist pamoic acid with a Ki value of 12.8 nM.{24501} It less potently blocks activation of GPR35 by zaprinast (Item No. 10010421) (IC50 = 160 nM).{24498} It shows ~57-fold selectivity for GPR35 over the related receptor GPR55 (IC50 = 9.08 µM).{24498}
Brand:CaymanSKU:12046 - 10 mgAvailable on backorder
GPR35 is a G protein-coupled receptor that is activated by kynurenic acid and 2-acyl lysophosphatidic acids (e.g., 2-oleoyl lysophosphatidic acid).{24499,14771,24500} It is expressed predominantly on immune cells, the brain, and in the gastrointestinal tract.{14857,14771} GPR35 is overexpressed in gastric cancer cells.{13309} CID-2745687 is a reversible, competitive antagonist of GPR35, blocking activation by the synthetic agonist pamoic acid with a Ki value of 12.8 nM.{24501} It less potently blocks activation of GPR35 by zaprinast (Item No. 10010421) (IC50 = 160 nM).{24498} It shows ~57-fold selectivity for GPR35 over the related receptor GPR55 (IC50 = 9.08 µM).{24498}
Brand:CaymanSKU:12046 - 25 mgAvailable on backorder
GPR35 is a G protein-coupled receptor that is activated by kynurenic acid and 2-acyl lysophosphatidic acids (e.g., 2-oleoyl lysophosphatidic acid).{24499,14771,24500} It is expressed predominantly on immune cells, the brain, and in the gastrointestinal tract.{14857,14771} GPR35 is overexpressed in gastric cancer cells.{13309} CID-2745687 is a reversible, competitive antagonist of GPR35, blocking activation by the synthetic agonist pamoic acid with a Ki value of 12.8 nM.{24501} It less potently blocks activation of GPR35 by zaprinast (Item No. 10010421) (IC50 = 160 nM).{24498} It shows ~57-fold selectivity for GPR35 over the related receptor GPR55 (IC50 = 9.08 µM).{24498}
Brand:CaymanSKU:12046 - 5 mgAvailable on backorder
GPR35 is a G protein-coupled receptor that is activated by kynurenic acid and 2-acyl lysophosphatidic acids (e.g., 2-oleoyl lysophosphatidic acid).{24499,14771,24500} It is expressed predominantly on immune cells, the brain, and in the gastrointestinal tract.{14857,14771} GPR35 is overexpressed in gastric cancer cells.{13309} CID-2745687 is a reversible, competitive antagonist of GPR35, blocking activation by the synthetic agonist pamoic acid with a Ki value of 12.8 nM.{24501} It less potently blocks activation of GPR35 by zaprinast (Item No. 10010421) (IC50 = 160 nM).{24498} It shows ~57-fold selectivity for GPR35 over the related receptor GPR55 (IC50 = 9.08 µM).{24498}
Brand:CaymanSKU:12046 - 50 mgAvailable on backorder
CID-2818500 is an inhibitor of protein arginine methyltransferase 1 (PRMT1; IC50 = 11 μM in a histone H4 methylation assay).{47652} It also inhibits histone H4 methylation by PRMT8, but not histone H3.1 methylation by CARM1 or Set7/9, when used at concentrations of 10 and 100 μM.
Brand:CaymanSKU:21919 -Out of stock
CID-2818500 is an inhibitor of protein arginine methyltransferase 1 (PRMT1; IC50 = 11 μM in a histone H4 methylation assay).{47652} It also inhibits histone H4 methylation by PRMT8, but not histone H3.1 methylation by CARM1 or Set7/9, when used at concentrations of 10 and 100 μM.
Brand:CaymanSKU:21919 -Out of stock
CID-2818500 is an inhibitor of protein arginine methyltransferase 1 (PRMT1; IC50 = 11 μM in a histone H4 methylation assay).{47652} It also inhibits histone H4 methylation by PRMT8, but not histone H3.1 methylation by CARM1 or Set7/9, when used at concentrations of 10 and 100 μM.
Brand:CaymanSKU:21919 -Out of stock
CID-2818500 is an inhibitor of protein arginine methyltransferase 1 (PRMT1; IC50 = 11 μM in a histone H4 methylation assay).{47652} It also inhibits histone H4 methylation by PRMT8, but not histone H3.1 methylation by CARM1 or Set7/9, when used at concentrations of 10 and 100 μM.
Brand:CaymanSKU:21919 -Out of stock
CID-2858522 is an 2-amino benzimidazole that inhibits activation of the NF-κB pathway induced by the PKC activator PMA with an IC50 value of 0.07 μM.{24527} It has been shown to inhibit IL-8 production induced by PKC activators in HEK293 cells (IC50 ≤ 0.1 μM), attenuate CD3/CD28 and PMA/ionomycin-induced production of IL-2 by Jurkat T cells (IC50 ≤ 5 μM), and prevent anti-IgM-stimulated proliferation of mouse B-lymphocytes (IC50 = ∼2 μM).{24527} CID-2858522 does not, however, inhibit the NF-κB pathway activated by TNF-α.{24527}
Brand:CaymanSKU:- CID-2858522 is an 2-amino benzimidazole that inhibits activation of the NF-κB pathway induced by the PKC activator PMA with an IC50 value of 0.07 μM.{24527} It has been shown to inhibit IL-8 production induced by PKC activators in HEK293 cells (IC50 ≤ 0.1 μM), attenuate CD3/CD28 and PMA/ionomycin-induced production of IL-2 by Jurkat T cells (IC50 ≤ 5 μM), and prevent anti-IgM-stimulated proliferation of mouse B-lymphocytes (IC50 = ∼2 μM).{24527} CID-2858522 does not, however, inhibit the NF-κB pathway activated by TNF-α.{24527}
Brand:CaymanSKU:- CID-2858522 is an 2-amino benzimidazole that inhibits activation of the NF-κB pathway induced by the PKC activator PMA with an IC50 value of 0.07 μM.{24527} It has been shown to inhibit IL-8 production induced by PKC activators in HEK293 cells (IC50 ≤ 0.1 μM), attenuate CD3/CD28 and PMA/ionomycin-induced production of IL-2 by Jurkat T cells (IC50 ≤ 5 μM), and prevent anti-IgM-stimulated proliferation of mouse B-lymphocytes (IC50 = ∼2 μM).{24527} CID-2858522 does not, however, inhibit the NF-κB pathway activated by TNF-α.{24527}
Brand:CaymanSKU:- CID-2858522 is an 2-amino benzimidazole that inhibits activation of the NF-κB pathway induced by the PKC activator PMA with an IC50 value of 0.07 μM.{24527} It has been shown to inhibit IL-8 production induced by PKC activators in HEK293 cells (IC50 ≤ 0.1 μM), attenuate CD3/CD28 and PMA/ionomycin-induced production of IL-2 by Jurkat T cells (IC50 ≤ 5 μM), and prevent anti-IgM-stimulated proliferation of mouse B-lymphocytes (IC50 = ∼2 μM).{24527} CID-2858522 does not, however, inhibit the NF-κB pathway activated by TNF-α.{24527}
Brand:CaymanSKU:-
Brand:CaymanSKU:22967 - 1 mgAvailable on backorder
Brand:CaymanSKU:22967 - 10 mgAvailable on backorder
Brand:CaymanSKU:22967 - 25 mgAvailable on backorder
Brand:CaymanSKU:22967 - 5 mgAvailable on backorder
CID-5951923 is an inhibitor of the transcription factor Krüppel-like factor 5 (KLF5; IC50 = 2.3 μM).{35317} It decreases KLF5 expression in and reduces growth of DLD-1 colorectal adenocarcinoma cells in a concentration-dependent manner. CID-5951923 selectively inhibits proliferation of cancer cell lines that highly express KLF5, particularly colon adenocarcinomas, in the NCI-60 panel of cancer cell lines.
Brand:CaymanSKU:21649 -Out of stock
CID-5951923 is an inhibitor of the transcription factor Krüppel-like factor 5 (KLF5; IC50 = 2.3 μM).{35317} It decreases KLF5 expression in and reduces growth of DLD-1 colorectal adenocarcinoma cells in a concentration-dependent manner. CID-5951923 selectively inhibits proliferation of cancer cell lines that highly express KLF5, particularly colon adenocarcinomas, in the NCI-60 panel of cancer cell lines.
Brand:CaymanSKU:21649 -Out of stock
CID-5951923 is an inhibitor of the transcription factor Krüppel-like factor 5 (KLF5; IC50 = 2.3 μM).{35317} It decreases KLF5 expression in and reduces growth of DLD-1 colorectal adenocarcinoma cells in a concentration-dependent manner. CID-5951923 selectively inhibits proliferation of cancer cell lines that highly express KLF5, particularly colon adenocarcinomas, in the NCI-60 panel of cancer cell lines.
Brand:CaymanSKU:21649 -Out of stock
CID-5951923 is an inhibitor of the transcription factor Krüppel-like factor 5 (KLF5; IC50 = 2.3 μM).{35317} It decreases KLF5 expression in and reduces growth of DLD-1 colorectal adenocarcinoma cells in a concentration-dependent manner. CID-5951923 selectively inhibits proliferation of cancer cell lines that highly express KLF5, particularly colon adenocarcinomas, in the NCI-60 panel of cancer cell lines.
Brand:CaymanSKU:21649 -Out of stock
CID16020046 is a GPR55 inverse agonist that antagonizes GPR55 constitutive activity with an IC50 value of 15 μM.{29659} It inhibits GPR55-mediated ERK1/2 phosphorylation, LPI-induced Ca2+ signaling (IC50 = 0.21 μM in HEK-GPR55 cells), and GPR55-mediated transcription factor activation.{29659} It does not affect ERK1/2 phosphorylation or transcription factor activation in CB receptor expressing cells and demonstrates weak activity against a broad spectrum of other GPCRs, ion channels, kinases, and nuclear receptors.{29659} This compound has been shown to block GPR55-mediated endothelial wound healing and reverse LPI-inhibited platelet aggregation.{29659}
Brand:CaymanSKU:- CID16020046 is a GPR55 inverse agonist that antagonizes GPR55 constitutive activity with an IC50 value of 15 μM.{29659} It inhibits GPR55-mediated ERK1/2 phosphorylation, LPI-induced Ca2+ signaling (IC50 = 0.21 μM in HEK-GPR55 cells), and GPR55-mediated transcription factor activation.{29659} It does not affect ERK1/2 phosphorylation or transcription factor activation in CB receptor expressing cells and demonstrates weak activity against a broad spectrum of other GPCRs, ion channels, kinases, and nuclear receptors.{29659} This compound has been shown to block GPR55-mediated endothelial wound healing and reverse LPI-inhibited platelet aggregation.{29659}
Brand:CaymanSKU:- CID16020046 is a GPR55 inverse agonist that antagonizes GPR55 constitutive activity with an IC50 value of 15 μM.{29659} It inhibits GPR55-mediated ERK1/2 phosphorylation, LPI-induced Ca2+ signaling (IC50 = 0.21 μM in HEK-GPR55 cells), and GPR55-mediated transcription factor activation.{29659} It does not affect ERK1/2 phosphorylation or transcription factor activation in CB receptor expressing cells and demonstrates weak activity against a broad spectrum of other GPCRs, ion channels, kinases, and nuclear receptors.{29659} This compound has been shown to block GPR55-mediated endothelial wound healing and reverse LPI-inhibited platelet aggregation.{29659}
Brand:CaymanSKU:- CID16020046 is a GPR55 inverse agonist that antagonizes GPR55 constitutive activity with an IC50 value of 15 μM.{29659} It inhibits GPR55-mediated ERK1/2 phosphorylation, LPI-induced Ca2+ signaling (IC50 = 0.21 μM in HEK-GPR55 cells), and GPR55-mediated transcription factor activation.{29659} It does not affect ERK1/2 phosphorylation or transcription factor activation in CB receptor expressing cells and demonstrates weak activity against a broad spectrum of other GPCRs, ion channels, kinases, and nuclear receptors.{29659} This compound has been shown to block GPR55-mediated endothelial wound healing and reverse LPI-inhibited platelet aggregation.{29659}
Brand:CaymanSKU:-
Protein kinase D (PKD) is a serine/threonine protein kinase that is activated by diacylglycerol, commonly downstream of PKC signaling.{13335} The three human PKD isoforms target a variety of proteins to alter cell proliferation, survival, invasion, and protein transport. CID755673 is a small molecule inhibitor of PKD (IC50s = 182, 280, 227 nM for PKD1, 2, and 3, respectively) that exhibits higher selectivity for PKD over Akt, polo-like kinase 1, CDK activating kinase, CAMKII and three different PKC isoforms (IC50s range from 15 to > 50 µM).{25787} At 25 µM, CID755673 has been shown to inhibit prostate cancer cell proliferation, cell migration, and invasion.{25787}
Brand:CaymanSKU:- Protein kinase D (PKD) is a serine/threonine protein kinase that is activated by diacylglycerol, commonly downstream of PKC signaling.{13335} The three human PKD isoforms target a variety of proteins to alter cell proliferation, survival, invasion, and protein transport. CID755673 is a small molecule inhibitor of PKD (IC50s = 182, 280, 227 nM for PKD1, 2, and 3, respectively) that exhibits higher selectivity for PKD over Akt, polo-like kinase 1, CDK activating kinase, CAMKII and three different PKC isoforms (IC50s range from 15 to > 50 µM).{25787} At 25 µM, CID755673 has been shown to inhibit prostate cancer cell proliferation, cell migration, and invasion.{25787}
Brand:CaymanSKU:- Protein kinase D (PKD) is a serine/threonine protein kinase that is activated by diacylglycerol, commonly downstream of PKC signaling.{13335} The three human PKD isoforms target a variety of proteins to alter cell proliferation, survival, invasion, and protein transport. CID755673 is a small molecule inhibitor of PKD (IC50s = 182, 280, 227 nM for PKD1, 2, and 3, respectively) that exhibits higher selectivity for PKD over Akt, polo-like kinase 1, CDK activating kinase, CAMKII and three different PKC isoforms (IC50s range from 15 to > 50 µM).{25787} At 25 µM, CID755673 has been shown to inhibit prostate cancer cell proliferation, cell migration, and invasion.{25787}
Brand:CaymanSKU:- Protein kinase D (PKD) is a serine/threonine protein kinase that is activated by diacylglycerol, commonly downstream of PKC signaling.{13335} The three human PKD isoforms target a variety of proteins to alter cell proliferation, survival, invasion, and protein transport. CID755673 is a small molecule inhibitor of PKD (IC50s = 182, 280, 227 nM for PKD1, 2, and 3, respectively) that exhibits higher selectivity for PKD over Akt, polo-like kinase 1, CDK activating kinase, CAMKII and three different PKC isoforms (IC50s range from 15 to > 50 µM).{25787} At 25 µM, CID755673 has been shown to inhibit prostate cancer cell proliferation, cell migration, and invasion.{25787}
Brand:CaymanSKU:-
CID797718 is a protein kinase D1 (PKD1) inhibitor (IC50 = 7 µM).{25787} It also inhibits CDK activating kinase (CAK) and polo-like kinase 1 (PLK1) but has no activity at AKT (IC50s = 8.4, 21.9, and >50 µM, respectively). CID797718 inhibits PKD1 activity in LNCaP cells with an IC50 value of 0.21 µM. CID797718 is a byproduct in the synthesis of CID755673 (Item No. 15924).{32618}
Brand:CaymanSKU:23428 - 1 mgAvailable on backorder
CID797718 is a protein kinase D1 (PKD1) inhibitor (IC50 = 7 µM).{25787} It also inhibits CDK activating kinase (CAK) and polo-like kinase 1 (PLK1) but has no activity at AKT (IC50s = 8.4, 21.9, and >50 µM, respectively). CID797718 inhibits PKD1 activity in LNCaP cells with an IC50 value of 0.21 µM. CID797718 is a byproduct in the synthesis of CID755673 (Item No. 15924).{32618}
Brand:CaymanSKU:23428 - 10 mgAvailable on backorder
CID797718 is a protein kinase D1 (PKD1) inhibitor (IC50 = 7 µM).{25787} It also inhibits CDK activating kinase (CAK) and polo-like kinase 1 (PLK1) but has no activity at AKT (IC50s = 8.4, 21.9, and >50 µM, respectively). CID797718 inhibits PKD1 activity in LNCaP cells with an IC50 value of 0.21 µM. CID797718 is a byproduct in the synthesis of CID755673 (Item No. 15924).{32618}
Brand:CaymanSKU:23428 - 25 mgAvailable on backorder
CID797718 is a protein kinase D1 (PKD1) inhibitor (IC50 = 7 µM).{25787} It also inhibits CDK activating kinase (CAK) and polo-like kinase 1 (PLK1) but has no activity at AKT (IC50s = 8.4, 21.9, and >50 µM, respectively). CID797718 inhibits PKD1 activity in LNCaP cells with an IC50 value of 0.21 µM. CID797718 is a byproduct in the synthesis of CID755673 (Item No. 15924).{32618}
Brand:CaymanSKU:23428 - 5 mgAvailable on backorder
Cidofovir is an acyclic nucleoside phosphonate that is active against herpesvirus (including cytomegalovirus (CMV)), polyomavirus, papillomavirus, adenovirus, and poxvirus infections. In vitro, cidofovir is converted to cidofovir diphosphate which incorporates into viral DNA, selectively inhibiting CMV replication and CMV DNA synthesis with IC50 values of 0.1 μM.{22167} Cidofovir has significantly long-lasting antiviral action because of the long half-life of its metabolites whose cellular uptake is slow due to the presence of the negatively charged phosphonate group.{22169} The antiviral efficacy of cidofovir has been demonstrated in numerous experimental animal model infections that mirror all major DNA virus infections in humans.{22168} It has also demonstrated remarkable activity as an antitumor agent in a variety of animal models of tumor growth.{22168}
Brand:CaymanSKU:-